diff --git "a/feature_interpretations.csv" "b/feature_interpretations.csv" new file mode 100644--- /dev/null +++ "b/feature_interpretations.csv" @@ -0,0 +1,16385 @@ +feature_id,term,z_score,auroc,label,aspect,term_by_z,label_by_z,auroc_by_z,n_carriers,source_database,stable_id,term_id,held_out_n_positive,n_total,held_out_auroc,held_out_ap,held_out_prevalence,held_out_recall_at_precision_50,held_out_ap_lift,concordance_hits,concordance_drawn,concordance_enrichment,concordance_q,biohub_label,assigned,status +0,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nudix N-terminal substrate-binding loop,False,no_term_above_threshold +1,25169,20.192104,0.85302734,pilus,go_cc,25169,pilus,0.85302734,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.791563055062167,0.08695756060510158,0.002215330084182543,,39.25264285714286,0.0,17.0,0.0,1.0,PsbO extracellular beta strand signature,True,assigned_and_evaluated +2,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Gly-rich capping loops,False,no_term_above_threshold +3,88161,57.110443,0.6845703,Transmembrane helix,keyword,88161,Transmembrane helix,0.6845703,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7077123084141382,0.47233385352467205,0.1847585290208241,0.513189448441247,2.556492823513633,13.0,14.0,5.039814032121725,6.6239830674169e-09,Acidic cytosolic juxtamembrane tails,True,assigned_and_evaluated +4,50806,16.838108,0.83740234,"Homeobox, conserved site",interpro,37071,Homeodomain,0.75878906,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,Disordered transcriptional effector regions,True,assigned_too_few_test_positives +5,64594,18.268948,0.9433594,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,88150,Transcription regulation,0.6435547,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.990606936416185,0.2753771805752004,0.003544528134692069,,77.69078706977841,1.0,18.0,13.143959435626101,0.11977573140954031,TF regulatory IDRs,True,assigned_and_evaluated +6,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter TM helices and boundaries,False,no_term_above_threshold +7,81349,15.981723,0.95947266,1.10.287.1490,gene3d,87326,Coiled coil,0.67285156,31,gene3d,1.10.287.1490,gene3d:gene3d:1.10.287.1490,,,,,,,,9.0,20.0,161.62319277108435,3.2854014668775478e-18,Solvent exposed coiled-coil face,True,assigned_too_few_test_positives +8,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid transporter transmembrane bundles,False,no_term_above_threshold +9,88058,35.459236,0.6723633,Signal,keyword,88058,Signal,0.6723633,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.665675753717107,0.13911897704670045,0.09127159946832078,,1.5242307339534122,5.0,20.0,1.801238670694864,0.21355299572385222,Hydrophobic helical and low-complexity regions,True,assigned_and_evaluated +10,36449,18.616093,1.0,EamA domain,interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8935547,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,16.0,19.0,896.5563909774436,8.73250535093086e-46,Aromatic transporter TM helices,True,assigned_too_few_test_positives +11,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered linker/terminal tails,False,no_term_above_threshold +12,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal cyclic dinucleotide sensor,False,no_term_above_threshold +13,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β-strand block,False,no_term_above_threshold +14,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse activation with structured peaks,False,no_term_above_threshold +15,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity linkers,False,no_term_above_threshold +16,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Modified peptide core detector,False,no_term_above_threshold +17,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding amphipathic helical scaffolds,False,no_term_above_threshold +18,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane proteases and catalytic motifs,False,no_term_above_threshold +19,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic beta-strand in pseudouridine synthases,False,no_term_above_threshold +20,88164,20.628948,0.7685547,Transposition,keyword,88164,Transposition,0.7685547,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8987122557726466,0.7604430660168365,0.002215330084182543,0.8,343.264,2.0,16.0,90.88567073170732,0.0003988394211171349,Transposase C-terminal dimerization helices,True,assigned_and_evaluated +21,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered flanks with motifs,False,no_term_above_threshold +22,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleosidase substrate-binding loops,False,no_term_above_threshold +23,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic ectodomains and His-rich loops,False,no_term_above_threshold +24,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytidine deaminase-like domain,False,no_term_above_threshold +25,88058,38.671234,0.67041016,Signal,keyword,88058,Signal,0.67041016,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6603657699535627,0.2299069539290351,0.09127159946832078,0.10679611650485436,2.5189320146496708,12.0,15.0,5.763963746223565,3.064545791166066e-08,Non-cytosolic soluble domains,True,assigned_and_evaluated +26,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLC12 cytoplasmic C-terminal domain,False,no_term_above_threshold +27,8138,19.466314,0.82421875,translation,go_bp,88022,Ribosomal protein,0.7714844,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.6347902174870124,0.06960547142700059,0.018165706690296855,0.024390243902439025,3.83169631733513,0.0,9.0,0.0,1.0,NTPase catalytic and coupling residues,True,assigned_and_evaluated +28,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Jelly-roll/CNBD metal/anion pockets,False,no_term_above_threshold +29,47128,17.08789,0.9770508,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9770508,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,17.0,18.0,242.71000957854406,8.70422654690493e-40,Beta-sandwich/propeller strand cores,True,assigned_too_few_test_positives +30,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic SBP N-terminal ligand-binding lobe,False,no_term_above_threshold +31,63951,19.402288,0.98535156,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9326172,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.999308026888098,0.7892687559354226,0.003987594151528578,1.0,197.93106468291654,19.0,19.0,161.13783783783785,7.848216272787399e-42,Ig-like YxC disulfide motif,True,assigned_and_evaluated +32,87882,16.713156,0.72998047,Palmitate,keyword,88058,Signal,0.6352539,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.7972012438916036,0.04694602171058397,0.002658396101019052,,17.659528500131337,5.0,18.0,18.504345127250154,1.031309184113659e-05,Extracytoplasmic envelope factors,True,assigned_and_evaluated +33,49116,17.329674,0.87402344,Armadillo-type fold,interpro,43624,Homedomain-like superfamily,0.8432617,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9186056838365897,0.01653077054284992,0.002215330084182543,,7.4619898230424555,1.0,15.0,5.802530413625304,0.25288864322742416,N-terminal amphipathic/hydrophobic helix,True,assigned_and_evaluated +34,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended beta-strand/LCR tracts,False,no_term_above_threshold +35,88240,15.917836,0.61083984,Virulence,keyword,88240,Virulence,0.61083984,306,keywords,Virulence,keyword:keywords:Virulence,20.0,2257.0,0.7362427358068842,0.17988754739977203,0.008861320336730172,0.15,20.300309724064274,2.0,19.0,3.7693061482535164,0.1578250587756593,Secreted protein mature region,True,assigned_and_evaluated +36,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase catalytic core,False,no_term_above_threshold +37,46284,16.400063,0.8901367,FMN-binding split barrel,interpro,85712,3.40.630.30,0.8671875,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,17.0,0.0,1.0,IclR effector-binding beta-alpha motif,True,assigned_too_few_test_positives +38,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma-factor N-terminal IDRs,False,no_term_above_threshold +39,64003,16.444174,0.8823242,Zinc finger C2H2 superfamily,interpro,88150,Transcription regulation,0.6723633,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9303084223013048,0.21345619784717262,0.003987594151528578,,53.53007094900762,9.0,18.0,65.2308533916849,8.98160361780241e-15,Non-core regulatory activation domains,True,assigned_and_evaluated +40,82029,21.45651,0.9848633,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.66796875,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,17.0,11.063462609018371,0.14078347170214411,Generic multi-pass transmembrane helices,True,assigned_too_few_test_positives +41,36876,16.29847,1.0,Cytochrome P450,interpro,87541,Heme,0.6665039,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,15.0,15.0,389.6797385620915,5.164997713117673e-39,Cytochrome P450 catalytic fold,True,assigned_and_evaluated +42,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short conserved ligand-binding patch,False,no_term_above_threshold +43,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase and transferase catalytic cores,False,no_term_above_threshold +44,63960,32.794453,0.92822266,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.92822266,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,15.0,15.0,193.57467532467533,1.7387176222033654e-34,N-terminal FAD-binding segment,True,assigned_too_few_test_positives +45,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended noncatalytic interaction segments,False,no_term_above_threshold +46,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ScpA/NSE4/EID3 mid-chain activation,False,no_term_above_threshold +47,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad conserved-motif activation,False,no_term_above_threshold +48,81739,15.9740715,0.95947266,"DNA helicase RuvA subunit, C-terminal domain",gene3d,81739,"DNA helicase RuvA subunit, C-terminal domain",0.95947266,27,gene3d,1.10.8.10,gene3d:gene3d:1.10.8.10,6.0,2257.0,0.9997038353324448,0.9107142857142856,0.002658396101019052,1.0,342.58035714285705,11.0,18.0,278.13019508057675,3.573991519578579e-25,C-terminal disordered low-complexity tails,True,assigned_and_evaluated +49,37097,19.431948,0.99853516,Cro/C1-type helix-turn-helix domain,interpro,37071,Homeodomain,0.9458008,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,18.0,19.0,532.8589870903673,5.994106586766902e-48,HTH/LysM hydrophobic packing,True,assigned_too_few_test_positives +50,50338,17.492237,0.8251953,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8251953,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,19.0,0.0,1.0,Asn-biased coiled-coil docking helices,True,assigned_too_few_test_positives +51,-1,,,,,-1,,,0,,,,,,,,,,,,,,,uS2 C-terminal helix motif,False,no_term_above_threshold +52,38873,16.893593,0.7553711,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63183594,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9982238010657193,0.6359649122807018,0.002215330084182543,0.8,287.0745614035088,15.0,16.0,160.61691810344828,1.5962557782442642e-32,ABC NBD LSGGQ signature,True,assigned_and_evaluated +53,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-metal phosphodiesterase/nuclease cores,False,no_term_above_threshold +54,63831,31.773422,0.9291992,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9291992,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9642381163927143,0.03941636172749695,0.002658396101019052,,14.8271214031601,0.0,14.0,0.0,1.0,REC β3–α2 and H-box,True,assigned_and_evaluated +55,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme N-terminal extensions,False,no_term_above_threshold +56,36535,18.96195,0.87109375,Protein kinase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6411133,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8918113039608367,0.21780882136744306,0.004430660168365086,,49.1594509826319,0.0,16.0,0.0,1.0,ABC NBD beta1/A-loop,True,assigned_and_evaluated +57,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed aromatic glycan-binding loops,False,no_term_above_threshold +58,88263,18.247887,0.70458984,Zinc-finger,keyword,88263,Zinc-finger,0.70458984,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.7965990843688686,0.09500166005269625,0.014621178555604785,,6.4975377799677405,3.0,18.0,4.343021561771561,0.049817725872857106,Modular globular binding domains,True,assigned_and_evaluated +59,36535,18.636656,0.97558594,Protein kinase domain,interpro,85656,alpha/beta hydrolase,0.9243164,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9898086337338673,0.7426440191860753,0.004430660168365086,0.8,167.6147551302972,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase catalytic core motifs,True,assigned_and_evaluated +60,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended electrostatic interaction surfaces,False,no_term_above_threshold +61,38654,17.740204,0.87646484,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.87646484,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,16.0,0.0,1.0,Acidic N-terminal activation IDRs,True,assigned_too_few_test_positives +62,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular vestibule pore loops,False,no_term_above_threshold +63,69819,19.020533,0.7373047,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.7319336,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,13.0,15.0,363.88403755868546,2.0547959238719107e-32,Hsp70 substrate-binding lobe activation,True,assigned_too_few_test_positives +64,88009,30.916613,0.72558594,Repeat,keyword,88009,Repeat,0.72558594,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.8407758731194575,0.32113824677385006,0.07266282676118742,0.23170731707317074,4.419567213223046,12.0,14.0,7.599065321295804,6.38697211531251e-10,KSRPYF coiled-coil motif,True,assigned_and_evaluated +65,82029,21.453115,0.99658203,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6464844,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,12.0,18.0,125.38590956887487,2.1429336678000915e-23,Transporter TM hydrophobic hotspot detector,True,assigned_too_few_test_positives +66,49061,15.694553,0.78515625,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.78515625,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8720037813241044,0.05954176912593744,0.012405848471422242,,4.799491889901457,0.0,16.0,0.0,1.0,Beta-propeller blade motifs,True,assigned_and_evaluated +67,47529,25.497551,0.9741211,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9741211,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.994436077643909,0.6279058724525185,0.007089056269384138,0.6875,88.57397213283339,17.0,17.0,77.32944228274968,2.872750145145074e-32,Repeated Ig/FN3 loop hydrophobics,True,assigned_and_evaluated +68,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix termini and loops,False,no_term_above_threshold +69,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periodic aromatic/Gly beta-repeat detector,False,no_term_above_threshold +70,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular anchoring/assembly; GH16 motif,False,no_term_above_threshold +71,61392,22.668465,0.99853516,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.61035156,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9987301587301587,0.6274170274170274,0.0031014621178555605,1.0,202.297175840033,20.0,20.0,167.4747191011236,3.4711901829092086e-44,LRR convex-face helix detector,True,assigned_and_evaluated +72,-1,,,,,-1,,,0,,,,,,,,,,,,,,,sPLA2 N-terminal disulfide/Ca2+ module,False,no_term_above_threshold +73,38654,22.004837,0.9057617,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.8857422,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,12.0,0.0,1.0,Pepsin-like aspartyl proteases,True,assigned_too_few_test_positives +74,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Radical SAM downstream aromatic/charged segment,False,no_term_above_threshold +75,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-capped flexible loops,False,no_term_above_threshold +76,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase TGD catalytic loop,False,no_term_above_threshold +77,87326,35.12224,0.73339844,Coiled coil,keyword,87326,Coiled coil,0.73339844,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7682402877399561,0.38238997037495065,0.03943287549844927,0.4044943820224719,9.697237788047905,17.0,19.0,11.28041980612347,6.733872062658451e-17,Coiled-coil heptad register,True,assigned_and_evaluated +78,36776,18.12604,0.9975586,SANT/Myb domain,interpro,80926,Homeodomain-like,0.89160156,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9988153413297793,0.6160714285714285,0.002658396101019052,1.0,231.74553571428567,0.0,19.0,0.0,1.0,HTH-like DNA-contacting turn,True,assigned_and_evaluated +79,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pervasive N-terminal nucleic-acid activation,False,no_term_above_threshold +80,27735,17.149786,0.7089844,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.7089844,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.677947108919767,0.09498535654082316,0.011519716437749225,0.11538461538461539,8.245459604332225,15.0,16.0,42.40871585735964,6.261496829763443e-24,Disordered low-complexity activation segments,True,assigned_and_evaluated +81,47531,17.095268,0.86083984,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.86083984,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,12.0,12.0,252.6313559322034,4.011928689790402e-29,Dus N-terminal TIM-barrel segment,True,assigned_too_few_test_positives +82,87856,17.251034,0.75097656,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.75097656,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5807296673716593,0.08141304585976716,0.012405848471422242,0.10714285714285714,6.562473018053375,14.0,14.0,84.68892045454545,2.9630149843605392e-27,Right-hand polymerase catalytic core,True,assigned_and_evaluated +83,63774,16.153095,0.9995117,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.99853516,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,6.0,15.0,73.15460122699388,2.5683973890779816e-10,Exposed aromatic stacking patches,True,assigned_too_few_test_positives +84,82107,15.919426,0.6298828,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.6123047,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,2.0,18.0,36.199757134183365,0.002424469153704885,RHS/YD β-strand repeat markers,True,assigned_too_few_test_positives +85,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-kinase/TatB cytoplasmic regions,False,no_term_above_threshold +86,36886,23.416454,0.95947266,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.95947266,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9324144064028457,0.4211199434871922,0.003544528134692069,0.5,118.80846405632411,0.0,17.0,0.0,1.0,GPCR/MFS TM core motifs,True,assigned_and_evaluated +87,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rod-like coiled-coil scaffolds,False,no_term_above_threshold +88,85762,18.258623,0.6850586,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.67333984,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,14.0,14.0,205.58965517241379,1.3323113268805393e-32,FAD oxidoreductase capping motif,True,assigned_too_few_test_positives +89,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDR tails,False,no_term_above_threshold +90,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic peripheral amphipathic helices/loops,False,no_term_above_threshold +91,64620,19.361362,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.98339844,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,HATPase_c F-box motif,True,assigned_too_few_test_positives +92,36535,20.795782,0.9526367,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9399414,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9474187805963508,0.8904430660168365,0.004430660168365086,0.9,200.973,13.0,13.0,89.79066265060241,1.1174852366600676e-25,Kinase P+1 loop LTGxPPF/Y,True,assigned_and_evaluated +93,87109,15.849942,0.7939453,ATP synthesis,keyword,87326,Coiled coil,0.62353516,92,keywords,ATP synthesis,keyword:keywords:ATP synthesis,24.0,2257.0,0.9305866547245857,0.16797085481120905,0.010633584404076208,0.08333333333333333,15.796259137870782,9.0,14.0,185.1583850931677,3.0859729856293246e-19,Long coiled-coil stator scaffolds,True,assigned_and_evaluated +94,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Ser/Pro-rich junction loops,False,no_term_above_threshold +95,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic N-terminal IMPase lobe,False,no_term_above_threshold +96,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphorylation-prone disordered linkers,False,no_term_above_threshold +97,87326,20.325161,0.6503906,Coiled coil,keyword,87326,Coiled coil,0.6503906,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6700941166715039,0.08949423478003807,0.03943287549844927,,2.2695335718937746,7.0,19.0,4.6448787436979,0.0007502888674391185,Coiled-coil oligomerization interface,True,assigned_and_evaluated +98,49116,23.934456,0.95654297,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.95654297,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9974245115452931,0.3235897435897436,0.002215330084182543,,146.06841025641026,16.0,18.0,77.36707218167072,4.170212708294483e-29,ARM/HEAT/TPR alpha-solenoid repeats,True,assigned_and_evaluated +99,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered regions and collagen repeats,False,no_term_above_threshold +100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered polybasic patches,False,no_term_above_threshold +101,87276,20.92745,0.60009766,Cell membrane,keyword,87276,Cell membrane,0.60009766,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.5762572839251171,0.18897453734912562,0.11120957022596367,0.05976095617529881,1.6992650629361614,15.0,19.0,6.47800860532835,9.72345638327814e-11,Gram-positive envelope targeting signals,True,assigned_and_evaluated +102,64154,15.828314,0.99902344,Cytochrome P450 superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9482422,36,ip,IPR036396,interpro:ip:IPR036396,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,379.75159235668787,3.775407694669663e-46,Cytochrome P450 catalytic domain,True,assigned_and_evaluated +103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KGT centered cofactor binding loop,False,no_term_above_threshold +104,87276,37.930016,0.67822266,Cell membrane,keyword,88161,Transmembrane helix,0.64941406,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7965029215143413,0.5471485129544134,0.11120957022596367,0.6454183266932271,4.9199768674825135,8.0,14.0,4.68884432385671,0.0001343282075018867,Transmembrane alpha helices,True,assigned_and_evaluated +105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPFH/MVP aromatic helix motif,False,no_term_above_threshold +106,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal docking patches,False,no_term_above_threshold +107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bilayer-interface amphipathic helices,False,no_term_above_threshold +108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Activation on non-catalytic regions,False,no_term_above_threshold +109,31094,17.087193,0.97265625,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.72998047,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9481308411214953,0.5823766879504585,0.004430660168365086,0.9,131.4424184704185,0.0,17.0,0.0,1.0,SDR VTRKIT substrate-binding helix,True,assigned_and_evaluated +110,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich acidic loops,False,no_term_above_threshold +111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +112,36876,15.660955,0.9892578,Cytochrome P450,interpro,87809,Monooxygenase,0.80029297,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9971579675761171,0.5301883301883301,0.003987594151528578,0.8888888888888888,132.95945124834012,0.0,16.0,0.0,1.0,Active-site flanking loops and strands,True,assigned_and_evaluated +113,59211,21.121468,0.9897461,Nucleotide-diphospho-sugar transferases,interpro,85656,alpha/beta hydrolase,0.8935547,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9997491039426524,0.9701359530211192,0.011076650420912717,1.0,87.58387383874664,19.0,19.0,244.34836065573774,4.317107890414195e-45,Asp-centered Mg2+-binding loop,True,assigned_and_evaluated +114,25169,17.477095,0.70166016,pilus,go_cc,25169,pilus,0.70166016,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.896802841918295,0.20568116125493174,0.002215330084182543,,92.8444761904762,0.0,17.0,0.0,1.0,Starch/glycogen-binding CBMs,True,assigned_and_evaluated +115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity regulatory scaffolds,False,no_term_above_threshold +116,37894,21.1224,0.81933594,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.81933594,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,9.0,0.0,1.0,Coiled-coil heptad repeats,True,assigned_too_few_test_positives +117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VFT/SBP-like extracellular sensors,False,no_term_above_threshold +118,63831,16.574629,0.91015625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.91015625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.86076558566563,0.016927460620681647,0.002658396101019052,,6.367546436813079,0.0,19.0,0.0,1.0,N-terminal helix-start motif,True,assigned_and_evaluated +119,36535,23.30485,0.96484375,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.95996094,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9479528259902092,0.8247673903411609,0.004430660168365086,0.8,186.15000000000003,10.0,18.0,49.88370147255689,2.60582301666971e-15,Kinase glycine-rich P-loop,True,assigned_and_evaluated +120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal extracytoplasmic domains,False,no_term_above_threshold +121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pilin-like periplasmic head loops,False,no_term_above_threshold +122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,uL1/EF-Ts translation machinery,False,no_term_above_threshold +123,36886,22.0233,0.9873047,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9873047,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.872054246331703,0.4672551796527206,0.003544528134692069,0.75,131.8243675595238,17.0,17.0,233.80784313725488,2.75549142438941e-40,Fungal zinc-cluster activation domains,True,assigned_and_evaluated +124,88161,71.91486,0.83251953,Transmembrane helix,keyword,88159,Transmembrane,0.82958984,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.902916145344594,0.6986119516779282,0.1847585290208241,0.9016786570743405,3.7812162468515207,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Hydrophobic transmembrane helix segments,True,assigned_and_evaluated +125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VAV motif in PUB/KdpD,False,no_term_above_threshold +126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal GntR effector surface,False,no_term_above_threshold +127,27733,15.809763,0.85058594,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,24917,nucleus,0.671875,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.9102895955782181,0.08470844331195666,0.0101905183872397,,8.312476371960269,0.0,20.0,0.0,1.0,Proline-rich Ser/Thr-biased IDRs,True,assigned_and_evaluated +128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic assembly interface segment,False,no_term_above_threshold +129,64155,17.315258,0.80126953,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.7636719,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,12.0,15.0,221.84558139534883,5.20313982495647e-27,Conserved RNA-binding alpha helix,True,assigned_too_few_test_positives +130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RTX C-terminal beta-sandwich motif,False,no_term_above_threshold +131,38317,22.387192,0.97265625,Pentatricopeptide repeat,interpro,88154,Transit peptide,0.93359375,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9123809523809524,0.2692220781693426,0.0031014621178555605,0.2857142857142857,86.80489006117233,0.0,18.0,0.0,1.0,N-terminal chloroplast transit peptide,True,assigned_and_evaluated +132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal catalytic-core helices,False,no_term_above_threshold +133,85364,20.916506,0.78222656,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.78222656,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,14.0,19.0,221.87506645401382,5.674299009632219e-31,Pocket-shaping hinge segment,True,assigned_too_few_test_positives +134,36354,16.323067,0.65966797,RNA recognition motif domain,interpro,36354,RNA recognition motif domain,0.65966797,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,16.0,0.0,1.0,M14 carboxypeptidase HDVTTADG motif,True,assigned_too_few_test_positives +135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic pocket beta-loops,False,no_term_above_threshold +136,64168,18.493753,0.87109375,HAD-like superfamily,interpro,55054,HAD superfamily,0.8618164,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.7853463587921847,0.05236834547240819,0.002215330084182543,,23.63907114624506,0.0,13.0,0.0,1.0,Gly/Thr-rich β–α phosphate-binding loop,True,assigned_and_evaluated +137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge interaction and gating loops,False,no_term_above_threshold +138,64003,24.167816,0.99658203,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.99121094,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,12.0,12.0,130.4617067833698,1.106011394999414e-25,C2H2 zinc-finger histidine detector,True,assigned_and_evaluated +139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Envelope coiled-coil scaffolds,False,no_term_above_threshold +140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site anion binding loops,False,no_term_above_threshold +141,37894,19.264656,0.9091797,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9091797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,12.0,0.0,1.0,NBD helical subdomain coupling helix,True,assigned_too_few_test_positives +142,87326,39.51002,0.8227539,Coiled coil,keyword,87326,Coiled coil,0.8227539,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8534868775654049,0.34653944424450134,0.03943287549844927,0.1797752808988764,8.788084557975726,10.0,17.0,7.416192952122698,2.2143391165396207e-07,Amphipathic coiled coil oligomerization helices,True,assigned_and_evaluated +143,50806,18.54253,0.9584961,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9121094,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,2.0,18.0,31.696438064859112,0.0031391628978869757,Conserved N-terminal hydrophobic helix,True,assigned_too_few_test_positives +144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-ATPase helicase accessory domains,False,no_term_above_threshold +145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-binding pocket residues,False,no_term_above_threshold +146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended assembly interface regions,False,no_term_above_threshold +147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic C-terminal accessory domains,False,no_term_above_threshold +148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Papain-like DUB catalytic core,False,no_term_above_threshold +149,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short mixed-charge motifs,False,no_term_above_threshold +150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helix-loop interface motif,False,no_term_above_threshold +151,36272,16.736416,0.9794922,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9794922,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,17.0,0.0,1.0,Terminal motifs and catalytic loops,True,assigned_too_few_test_positives +152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered lumenal C-terminal tails,False,no_term_above_threshold +153,59211,19.842867,0.9916992,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9916992,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9974193548387097,0.8445160695317853,0.011076650420912717,0.96,76.24291075732957,19.0,19.0,244.34836065573774,4.317107890414195e-45,Glycosyltransferase aromatic loop motif,True,assigned_and_evaluated +154,63831,24.00958,0.96777344,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.96777344,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9021175773730193,0.02497634474500987,0.002658396101019052,,9.39526834824788,0.0,17.0,0.0,1.0,Transmembrane helices and interfaces,True,assigned_and_evaluated +155,37071,18.842716,0.9658203,Homeodomain,interpro,87384,DNA-binding,0.65478516,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,2.0,19.0,21.715898743398284,0.006540099143353746,Short basic DNA recognition helix,True,assigned_too_few_test_positives +156,50338,19.187382,0.9555664,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.89404297,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,GT-C acidic juxtamembrane loop,True,assigned_too_few_test_positives +157,37020,17.224497,0.9477539,"Glycosyl transferase, family 1",interpro,2772,2.4.-.-,0.8588867,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,14.0,0.0,1.0,PAS/LOV helix-entry acidic patches,True,assigned_too_few_test_positives +158,46277,20.629078,0.97998047,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.97998047,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9846595968590626,0.5060369747211853,0.004873726185201595,0.45454545454545453,103.82958654051957,9.0,17.0,99.57116348116534,1.707914804720625e-16,OB-fold binding hotspot,True,assigned_and_evaluated +159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long polyampholytic disordered regions,False,no_term_above_threshold +160,36104,25.749487,0.9760742,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9760742,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Aromatic/Gly-Pro β-edge hotspots,True,assigned_too_few_test_positives +161,84152,32.09171,0.9711914,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9711914,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,17.0,529.3762486126526,6.9638923435125194e-43,Amidohydrolase substrate-binding loop,True,assigned_too_few_test_positives +162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-domain activation,False,no_term_above_threshold +163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C extracytoplasmic WWDXG loops,False,no_term_above_threshold +164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T-rich low-complexity linkers,False,no_term_above_threshold +165,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical interaction platforms,False,no_term_above_threshold +166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VWA-adjacent hydrophobic motif,False,no_term_above_threshold +167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pocket-lining beta-hairpin,False,no_term_above_threshold +168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short flexible N-terminal/linker segments,False,no_term_above_threshold +169,82029,27.628284,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS transmembrane helical cores,True,assigned_too_few_test_positives +170,85672,18.705065,0.6196289,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6176758,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5775426484566512,0.07818946727758203,0.01595037660611431,0.05555555555555555,4.902045212375073,9.0,9.0,40.01409395973155,8.640244049603615e-15,ASCE pre‑Walker A motif,True,assigned_and_evaluated +171,36010,16.908794,0.9301758,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.83154297,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,14.0,0.0,1.0,NG-motif beta-alpha loop,True,assigned_too_few_test_positives +172,37341,18.43107,0.90478516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8696289,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9559292476332836,0.12083940783480757,0.011962782454585734,,10.10127938826521,0.0,13.0,0.0,1.0,Structural beta-strand register detector,True,assigned_and_evaluated +173,45324,19.955507,0.89453125,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.89453125,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.5933392539964476,0.014272264067346035,0.002215330084182543,,6.442500000000001,10.0,18.0,303.87869520897044,3.352734230927883e-23,Surface-exposed solenoidal repeats,True,assigned_and_evaluated +174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TOPRIM-like catalytic core segments,False,no_term_above_threshold +175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved N-terminal linker motifs,False,no_term_above_threshold +176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Disordered polar tails, PPxY motifs",False,no_term_above_threshold +177,27733,16.557775,0.83691406,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.8149414,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8190514187847884,0.11093244720392638,0.0101905183872397,,10.88584927562008,4.0,19.0,11.30791844476055,0.0006615331211708729,Prion-like low-complexity IDRs,True,assigned_and_evaluated +178,36535,23.777576,0.9560547,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9433594,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9471517578994214,0.57899284956662,0.004430660168365086,0.9,130.67868614718614,0.0,16.0,0.0,1.0,GHKL ATP-site helix,True,assigned_and_evaluated +179,88263,23.581656,0.75390625,Zinc-finger,keyword,88263,Zinc-finger,0.75390625,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.7853921408327883,0.06777676265650777,0.014621178555604785,,4.635519797446607,0.0,20.0,0.0,1.0,Short hydrophobic beta-strand motif,True,assigned_and_evaluated +180,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping segments,False,no_term_above_threshold +181,47529,25.625008,0.98535156,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.98535156,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9954679830432842,0.6358087891090818,0.007089056269384138,0.625,89.68877731369984,14.0,18.0,60.14512177547197,2.7100217262699095e-23,Ig-like loop ligand patches,True,assigned_and_evaluated +182,88058,24.317934,0.62939453,Signal,keyword,88058,Signal,0.62939453,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6041689348790313,0.13418172887519125,0.09127159946832078,0.0048543689320388345,1.470136709084013,8.0,20.0,2.8819818731117826,0.0062651088960540115,Surface-exposed charge patches,True,assigned_and_evaluated +183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal hydrophobic helical activation,False,no_term_above_threshold +184,86130,22.388124,0.8886719,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.8803711,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9937460317460317,0.25785990071704357,0.0031014621178555605,,83.14139941690962,0.0,16.0,0.0,1.0,Actin/PIP2-regulated gelsolin repeats,True,assigned_and_evaluated +185,37097,27.744593,0.8535156,Cro/C1-type helix-turn-helix domain,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.82666016,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,12.0,0.0,1.0,Interdomain active-site gating hinge,True,assigned_too_few_test_positives +186,45290,16.528093,0.8173828,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.8173828,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7978541066776362,0.016342425211308645,0.0057598582188746125,,2.8372964386095085,0.0,8.0,0.0,1.0,ATP-contact beta-strand motif,True,assigned_and_evaluated +187,36104,16.01175,0.82373047,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.82373047,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Cell-envelope glycan interface and biosynthesis,True,assigned_too_few_test_positives +188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal low-complexity amphipathic helices,False,no_term_above_threshold +189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tryptophan residue detector,False,no_term_above_threshold +190,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar repeat interaction surfaces,False,no_term_above_threshold +191,87586,15.917533,0.67822266,Host membrane,keyword,88161,Transmembrane helix,0.65234375,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.5470294618943268,0.018933135355353188,0.01639344262295082,,1.1549212566765443,3.0,18.0,10.765799927771758,0.004398609427771213,Juxtamembrane TM-soluble boundary motif,True,assigned_and_evaluated +192,55053,22.988855,0.9692383,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9692383,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,15.0,17.0,487.0996732026143,2.8227425437807618e-39,E2 acyltransferase hydrophobic core,True,assigned_too_few_test_positives +193,36535,22.994453,0.92089844,Protein kinase domain,interpro,64016,Thioredoxin-like superfamily,0.81591797,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9481975967957276,0.5964675970413675,0.004430660168365086,0.9,134.62273665223665,0.0,10.0,0.0,1.0,Chemotaxis receptor coiled-coil motif,True,assigned_and_evaluated +194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Edge-of-sheet patches,False,no_term_above_threshold +195,38317,15.966122,0.8613281,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8613281,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7714603174603174,0.01041584757573927,0.0031014621178555605,,3.3583668540633616,0.0,16.0,0.0,1.0,Active-site β–α loop linkers,True,assigned_and_evaluated +196,87276,45.183376,0.72314453,Cell membrane,keyword,88161,Transmembrane helix,0.68115234,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8166009938312552,0.5511476848407945,0.11120957022596367,0.6693227091633466,4.955937548548499,13.0,17.0,6.274776962808245,3.902843252195719e-09,TM helix C-terminal exit,True,assigned_and_evaluated +197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-site scaffold segments,False,no_term_above_threshold +198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,QueA N-terminal substrate-binding peak,False,no_term_above_threshold +199,66234,15.81547,0.7680664,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.7680664,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,18.0,18.0,236.59126984126982,1.243423145389655e-42,UBL deconjugase His–Asp core,True,assigned_too_few_test_positives +200,87108,19.532751,0.89404297,ANK repeat,keyword,87108,ANK repeat,0.89404297,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8909153815737446,0.018653597456980434,0.003987594151528578,,4.67790771782276,0.0,18.0,0.0,1.0,TIM-barrel scaffold helices,True,assigned_and_evaluated +201,46284,15.956846,0.98046875,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.98046875,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,19.0,0.0,1.0,Acidic surface caps and loops,True,assigned_too_few_test_positives +202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal EthD-domain polyketide enzymes,False,no_term_above_threshold +203,37020,17.867044,0.9555664,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.8071289,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,6.0,17.0,288.25624496373894,7.624958598145179e-14,Transmembrane glycine hinge,True,assigned_too_few_test_positives +204,37020,19.691156,0.9951172,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9628906,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,17.0,768.6833199033038,1.7917833648140597e-45,Glycosyltransferase C-terminal cap helix,True,assigned_too_few_test_positives +205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed beta-barrel loop motif,False,no_term_above_threshold +206,64148,36.75629,0.8925781,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.86865234,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9375852499882414,0.49645764123722025,0.008418254319893664,0.3157894736842105,58.97394190907401,6.0,18.0,29.662189054726365,6.474787479882004e-08,Amphipathic interface helices,True,assigned_and_evaluated +207,46082,15.890456,0.89160156,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.89160156,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9952380952380953,0.38351125065410774,0.0031014621178555605,0.14285714285714285,123.65498467518874,16.0,18.0,134.16821378340364,6.905004467510094e-33,FERM-targeted activation signature,True,assigned_and_evaluated +208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic helical residue signal,False,no_term_above_threshold +209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS PAC cap/linker,False,no_term_above_threshold +210,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Formin FH2 and DAD activation,False,no_term_above_threshold +211,58239,16.466043,0.6147461,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6147461,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6938317546233649,0.29223556718436783,0.017722640673460344,0.25,16.489391878377955,17.0,17.0,35.851473241130485,1.1097904818074523e-26,Q-loop coupling module,True,assigned_and_evaluated +212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class I aaRS adenylate pocket,False,no_term_above_threshold +213,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RGG/GP-rich low-complexity IDRs,False,no_term_above_threshold +214,49230,17.108068,0.9609375,Acyl-CoA N-acyltransferase,interpro,45290,Protein kinase-like domain superfamily,0.9355469,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,17.0,0.0,1.0,Acidic beta-strand catalytic motif,True,assigned_too_few_test_positives +215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand–loop allosteric switches,False,no_term_above_threshold +216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GINS core helices and tails,False,no_term_above_threshold +217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Aromatic CBM-like beta patches,False,no_term_above_threshold +218,82029,27.506796,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,19.0,158.38220156068402,1.2522467477825838e-33,MFS GxxxG gating helices,True,assigned_too_few_test_positives +219,85682,16.643053,0.7993164,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7993164,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9560125448028673,0.5018165937990615,0.011076650420912717,0.64,45.304002088179274,0.0,14.0,0.0,1.0,PsiMP glycosidase catalytic motif,True,assigned_and_evaluated +220,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phenylalanine-rich hydrophobic motif detector,False,no_term_above_threshold +221,48883,17.899584,0.9814453,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9814453,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,Type I PLP small-domain loop,True,assigned_too_few_test_positives +222,47529,24.840706,0.85009766,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.85009766,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8328313253012049,0.37604740079125326,0.007089056269384138,0.4375,53.04618647411616,8.0,16.0,38.66472114137484,1.9105831586339048e-11,Beta-strand capping loops,True,assigned_and_evaluated +223,47128,16.99912,0.7944336,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.7944336,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,9.0,19.0,121.7307168784029,3.812488452602612e-17,Extracellular glycan-binding motifs,True,assigned_too_few_test_positives +224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop capping hotspots,False,no_term_above_threshold +225,45551,19.468122,0.8779297,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8779297,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,18.0,0.0,1.0,Repeat-scaffold boundary linkers,True,assigned_too_few_test_positives +226,37020,16.334333,0.9272461,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.79296875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,19.0,0.0,1.0,Target-recognition β–α junction motif,True,assigned_too_few_test_positives +227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular domain starts and linkers,False,no_term_above_threshold +228,59229,19.119888,0.6694336,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6694336,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.5584056673543263,0.13929610294542583,0.0101905183872397,0.13043478260869565,13.669187145557656,17.0,17.0,106.27629233511585,1.3819031749869367e-34,Pre-SAM Rossmann N-lobe activation,True,assigned_and_evaluated +229,45804,17.155334,0.94433594,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.63916016,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,1.0,17.0,16.236655773420477,0.0981365503380171,Hydrophobic TM helix packing motif,True,assigned_too_few_test_positives +230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan/ribose catalytic domains,False,no_term_above_threshold +231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding catalytic microenvironments,False,no_term_above_threshold +232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular surface loop tracts,False,no_term_above_threshold +233,64016,20.628716,0.8261719,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.81933594,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7631428571428571,0.0611634033795002,0.0031014621178555605,,19.720828775361706,0.0,17.0,0.0,1.0,Soluble PTS regulatory domains,True,assigned_and_evaluated +234,45288,20.938683,0.89404297,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.89404297,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,0.0,14.0,0.0,1.0,Rhodanese-like C-terminal scaffold,True,assigned_too_few_test_positives +235,59229,17.345146,0.87646484,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8203125,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9096181542174301,0.07415111105381123,0.0101905183872397,,7.276480767323997,1.0,17.0,6.251546607947992,0.2361534288859562,Active-site adjacent helices,True,assigned_and_evaluated +236,50869,17.78612,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.67626953,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,20.0,20.0,917.2461538461538,5.886799965512069e-58,HTH/wH recognition helix loop,True,assigned_too_few_test_positives +237,30398,19.976345,0.6621094,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.60253906,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6298470007285679,0.2535445281346921,0.004873726185201595,0.2727272727272727,52.02272727272728,15.0,15.0,72.00603864734299,4.153748814633804e-28,ABC NBD pre-P-loop loop,True,assigned_and_evaluated +238,85656,16.65871,0.8120117,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.8095703,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.888,0.04138839751669049,0.0031014621178555605,,13.344801885024347,0.0,11.0,0.0,1.0,Flexible anion-recognition loops,True,assigned_and_evaluated +239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory nucleic-acid recognition domains,False,no_term_above_threshold +240,41154,15.666772,0.82177734,Phosphopantetheine attachment site,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.76416016,29,ip,IPR006162,interpro:ip:IPR006162,8.0,2257.0,0.6174966651845264,0.03275098869361164,0.003544528134692069,,9.239872685185185,0.0,10.0,0.0,1.0,Re-entrant TM junction helices,True,assigned_and_evaluated +241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory glycan-binding regions,False,no_term_above_threshold +242,85664,16.372705,0.9580078,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9580078,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,2.0,16.0,41.40347222222222,0.00185692223483761,Active-site-adjacent beta-loop motif,True,assigned_too_few_test_positives +243,36104,16.304068,0.7324219,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.7324219,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,12.0,0.0,1.0,Acidic–aromatic motif-rich segments,True,assigned_too_few_test_positives +244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-transmembrane cytosolic regions,False,no_term_above_threshold +245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/aromatic-anchored disordered SLiMs,False,no_term_above_threshold +246,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory low-complexity IDRs,False,no_term_above_threshold +247,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphorylation-dense regulatory IDRs,False,no_term_above_threshold +248,72011,16.28507,0.95458984,"AMP-binding enzyme, C-terminal domain superfamily",interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7167969,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,SAM-dependent nucleic-acid MTase core,True,assigned_too_few_test_positives +249,58239,20.330935,0.6035156,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6035156,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.569959404600812,0.09550626620868198,0.017722640673460344,0.1,5.388941070824881,15.0,15.0,35.851473241130485,1.3063198800490947e-23,RecA-like P-loop ATPase core,True,assigned_and_evaluated +250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sandwich ligand-recognition loops,False,no_term_above_threshold +251,64026,15.714547,0.7338867,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.7338867,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7204205538279282,0.11308718891808944,0.002658396101019052,,42.53963089802131,0.0,12.0,0.0,1.0,C-terminal transmembrane module,True,assigned_and_evaluated +252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature protein domain detector,False,no_term_above_threshold +253,49116,19.503479,0.7216797,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.7216797,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.894360568383659,0.22721074278451328,0.002215330084182543,0.2,102.5629292929293,0.0,17.0,0.0,1.0,Extracellular glycan-targeting catalytic surfaces,True,assigned_and_evaluated +254,59224,18.227388,0.875,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.81103516,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9594603174603173,0.05577340321241765,0.0031014621178555605,,17.98293872148952,2.0,16.0,17.171947004608295,0.010183055479603688,Polar segments adjacent active sites,True,assigned_and_evaluated +255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic N-terminal interaction regions,False,no_term_above_threshold +256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop-helix scaffold,False,no_term_above_threshold +257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extracellular accessory domains,False,no_term_above_threshold +258,48880,24.629992,0.9614258,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.9614258,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,17.0,17.0,484.7235772357723,1.7310182502290982e-45,N-terminal PLP gating helix-loop-helix,True,assigned_too_few_test_positives +259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavoprotein FAD/FMN-binding subdomain,False,no_term_above_threshold +260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent nuclease catalytic cores,False,no_term_above_threshold +261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity linker stalks,False,no_term_above_threshold +262,88154,29.781246,0.8803711,Transit peptide,keyword,88154,Transit peptide,0.8803711,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.9709191670398568,0.564750832739104,0.010633584404076208,0.875,53.110109562173236,16.0,18.0,25.953204918924797,1.3161655732908306e-21,Chloroplast mature domain signature,True,assigned_and_evaluated +263,85762,22.87548,0.7607422,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.7607422,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,18.0,205.58965517241379,1.4365296813653038e-41,FAD active-site capping loops,True,assigned_too_few_test_positives +264,87276,26.473549,0.61621094,Cell membrane,keyword,88161,Transmembrane helix,0.60839844,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7112785150524522,0.3125376289500673,0.11120957022596367,0.4820717131474104,2.8103483208776967,0.0,16.0,0.0,1.0,Glycine-zipper transmembrane helices,True,assigned_and_evaluated +265,64058,17.89744,0.6430664,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.6430664,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8531781415196485,0.28508259742334985,0.006202924235711121,,45.95938731317862,0.0,13.0,0.0,1.0,Crotonase-fold acyl-CoA tunnel,True,assigned_and_evaluated +266,87149,21.723948,0.6503906,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6503906,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6970454399794912,0.07870468614548148,0.012405848471422242,,6.344159879655418,0.0,16.0,0.0,1.0,Membrane-active helical segments,True,assigned_and_evaluated +267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHFR-like pterin reductases,False,no_term_above_threshold +268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial helix caps and turns,False,no_term_above_threshold +269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylated luminal ectodomains,False,no_term_above_threshold +270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cation-coupled transporter TM helices,False,no_term_above_threshold +271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta-strand core,False,no_term_above_threshold +272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline helix-loop motifs,False,no_term_above_threshold +273,87105,19.727694,0.9082031,4Fe-4S,keyword,87681,Iron-sulfur,0.8666992,93,keywords,4Fe-4S,keyword:keywords:4Fe-4S,,,,,,,,0.0,11.0,0.0,1.0,Fe-S/ferredoxin redox loops,True,assigned_too_few_test_positives +274,52940,17.271658,0.9897461,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.95214844,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,1.0,16.0,38.02359693877551,0.04344145960883729,Fold-type I PLP His-IxxTT motif,True,assigned_too_few_test_positives +275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich multivalent docking IDRs,False,no_term_above_threshold +276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asp-centered cofactor-binding loop,False,no_term_above_threshold +277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAPS-dependent sulfotransferase catalytic core,False,no_term_above_threshold +278,38873,18.700558,0.9902344,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9560547,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9993783303730017,0.8833333333333333,0.002215330084182543,0.8,398.7366666666667,10.0,12.0,142.7705938697318,7.017673639787694e-21,Walker A P-loop ATP-binding site,True,assigned_and_evaluated +279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding loops; helical/beta peaks,False,no_term_above_threshold +280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core secondary-structure patch,False,no_term_above_threshold +281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-cleft adjacent beta-loop,False,no_term_above_threshold +282,87105,15.659643,0.71972656,4Fe-4S,keyword,87105,4Fe-4S,0.71972656,93,keywords,4Fe-4S,keyword:keywords:4Fe-4S,,,,,,,,13.0,14.0,138.0607410046313,2.1825483396576575e-27,Radical SAM GR-loop pocket,True,assigned_too_few_test_positives +283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane linkers,False,no_term_above_threshold +284,64620,16.615833,0.9814453,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.92041016,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,HATPase_c Gxxx[C/S/T] helix motif,True,assigned_too_few_test_positives +285,50338,20.766323,0.9526367,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.92626953,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,8.0,17.0,184.58513931888544,8.546320838141518e-17,GPCR-like 7TM membrane bundle,True,assigned_too_few_test_positives +286,49121,21.52232,0.9746094,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.9746094,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,17.0,17.0,977.3934426229509,1.5932300158717148e-50,N-terminal sensors in transcription regulators,True,assigned_too_few_test_positives +287,85364,17.67261,0.7133789,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7133789,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,2.0,11.0,54.7483930211203,0.0010476912067103779,Extracellular VFT/PBP ligand-binding domains,True,assigned_too_few_test_positives +288,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted ectodomain glycosylation/targeting motifs,False,no_term_above_threshold +289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic TM1 helix caps,False,no_term_above_threshold +290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic targeting helices,False,no_term_above_threshold +291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic C-terminal hydrophobic caps,False,no_term_above_threshold +292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic hydrophobic/basic interface,False,no_term_above_threshold +293,87857,19.07259,0.6591797,Nucleus,keyword,24917,nucleus,0.6557617,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7596730080843019,0.18187039358031332,0.06247230837394772,,2.911216158232391,7.0,20.0,2.120665650406504,0.0586636576213421,Low-complexity FG-rich IDRs,True,assigned_and_evaluated +294,64148,24.955376,0.9453125,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.91503906,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9699096938055595,0.3565934707154085,0.008418254319893664,0.5789473684210527,42.359550705509314,7.0,19.0,32.78452474469756,2.0208932028118353e-09,Conserved hydrophobic anchor residue,True,assigned_and_evaluated +295,87276,46.391254,0.7753906,Cell membrane,keyword,88161,Transmembrane helix,0.7739258,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8540970713357934,0.6486305329048667,0.11120957022596367,0.7091633466135459,5.832506425363682,8.0,12.0,5.470318377832829,2.8247377570177352e-05,Polytopic transmembrane helices,True,assigned_and_evaluated +296,88058,34.28243,0.6279297,Signal,keyword,88058,Signal,0.6279297,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5869348600966614,0.18167727774538844,0.09127159946832078,0.0825242718446602,1.9905126984045713,13.0,14.0,6.690315062580924,1.8049522731864162e-10,Conserved SCP/CAP hydrophobic-aromatic surface motif,True,assigned_and_evaluated +297,88058,93.20496,0.8857422,Signal,keyword,88058,Signal,0.8857422,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9130260872034952,0.6597327726030233,0.09127159946832078,0.8592233009708737,7.228237222160309,20.0,20.0,7.204954682779456,1.6966660215964757e-17,Signal peptide c-region,True,assigned_and_evaluated +298,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate/adenylate-binding enzyme cores,False,no_term_above_threshold +299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-adjacent capping segments,False,no_term_above_threshold +300,87852,18.952944,0.94189453,Nucleosome core,keyword,87384,DNA-binding,0.72265625,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,20.0,0.0,1.0,AT-hook-like basic IDRs,True,assigned_too_few_test_positives +301,82029,31.630398,0.9980469,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Transporter cytosolic tail disorder,True,assigned_too_few_test_positives +302,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-biased beta-loop scaffolds,False,no_term_above_threshold +303,37282,26.387154,0.9165039,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.81347656,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,0.0,20.0,0.0,1.0,STAS-typified acidic loop motif,True,assigned_too_few_test_positives +304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PIN/NYN endoribonuclease catalytic core,False,no_term_above_threshold +305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory-pathway ectodomains,False,no_term_above_threshold +306,46078,19.300999,0.98046875,Armadillo-like helical,interpro,82597,Tetratricopeptide repeat domain,0.8847656,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,17.0,19.0,116.98487996306555,6.291394647743322e-34,HEAT/ARM alpha-solenoid repeats,True,assigned_too_few_test_positives +307,45290,17.306095,0.7133789,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7133789,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6873371726312902,0.21833899292915687,0.0057598582188746125,0.23076923076923078,37.90700823393131,14.0,15.0,68.52988505747128,3.0474954144632634e-25,PI3K-like kinase catalytic core,True,assigned_and_evaluated +308,37894,17.183022,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8852539,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR IVN(S/T) substrate strand,True,assigned_too_few_test_positives +309,28025,24.324886,0.8364258,GTPase activity,go_mf,29034,GTP binding,0.74365234,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9159632755812234,0.7528240183977889,0.002658396101019052,0.8333333333333334,283.1873015873016,8.0,9.0,240.89292929292927,6.840349735170457e-19,G-domain C-terminal extension,True,assigned_and_evaluated +310,39971,17.565266,0.9140625,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,61392,Leucine-rich repeat domain superfamily,0.7841797,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,19.0,0.0,1.0,Recurrent acidic amphipathic helix,True,assigned_too_few_test_positives +311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane segment detector,False,no_term_above_threshold +312,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Release factor GGQ signature,False,no_term_above_threshold +313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core packing signal,False,no_term_above_threshold +314,87913,21.38325,1.0,Phosphopantetheine,keyword,87913,Phosphopantetheine,1.0,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,1.0,0.9999999999999998,0.006202924235711121,1.0,161.21428571428567,17.0,18.0,454.1025985663082,2.63027887632995e-44,Amphipathic interdomain docking linkers,True,assigned_and_evaluated +315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble metallo hydrolase catalytic signature,False,no_term_above_threshold +316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical scaffolds,False,no_term_above_threshold +317,64058,16.191753,0.8334961,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8222656,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9581555314948093,0.06870066187394201,0.006202924235711121,,11.075528132106223,0.0,17.0,0.0,1.0,Helical hydrophobic core residues,True,assigned_and_evaluated +318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain activation,False,no_term_above_threshold +319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed turn-rich catalytic loops,False,no_term_above_threshold +320,48767,18.490007,0.99316406,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.9790039,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,18.0,0.0,1.0,OB-fold nucleic-acid-binding patches,True,assigned_too_few_test_positives +321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane anchor helices,False,no_term_above_threshold +322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic signal and transmembrane helices,False,no_term_above_threshold +323,25167,17.607315,0.65527344,cell outer membrane,go_cc,25167,cell outer membrane,0.65527344,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.6212138084632517,0.17065426081819524,0.005316792202038104,0.25,32.09722222222222,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel loops,True,assigned_and_evaluated +324,61392,25.133755,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9992380952380953,0.7947278911564624,0.0031014621178555605,1.0,256.24297862001936,19.0,19.0,167.4747191011236,3.9106228067767924e-42,Conserved LRR hydrophobic stripe,True,assigned_and_evaluated +325,36354,18.190016,0.89746094,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.89404297,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,15.0,0.0,1.0,N-terminal hydrophobic sensor segments,True,assigned_too_few_test_positives +326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs and ACT domains,False,no_term_above_threshold +327,49061,30.495497,0.96533203,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96533203,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9966673075690573,0.6279044300327294,0.012405848471422242,1.0,50.613582092281085,8.0,12.0,65.9159756771697,1.1338590491661621e-13,N-terminal beta-propeller initiation,True,assigned_and_evaluated +328,81685,15.817553,0.9321289,Transferase(Phosphotransferase) domain 1,gene3d,29033,ATP binding,0.68603516,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9795285820341498,0.3588320439726973,0.005316792202038104,0.6666666666666666,67.49032693719815,0.0,18.0,0.0,1.0,Phosphate-binding catalytic residues,True,assigned_and_evaluated +329,85672,16.10861,0.67529297,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.67529297,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7099029466206415,0.03913855079924709,0.01595037660611431,,2.453769698719464,1.0,12.0,3.3345078299776287,0.4115812093096781,Pro-anchored beta-alpha loops,True,assigned_and_evaluated +330,85762,27.398949,0.8701172,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.86816406,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,16.0,205.58965517241379,4.0182436921199225e-37,FAD-binding glycine-loop helix,True,assigned_too_few_test_positives +331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short loop beta strands,False,no_term_above_threshold +332,43643,20.038754,1.0,Phosphopantetheine binding ACP domain,interpro,87913,Phosphopantetheine,1.0,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,1.0,1.0,0.0057598582188746125,1.0,173.6153846153846,13.0,13.0,527.6194690265487,1.0768391390680534e-35,PCP/ACP pre-serine loop activation,True,assigned_and_evaluated +333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic glycan acylation machinery,False,no_term_above_threshold +334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carboxylation and nucleotide cofactor cores,False,no_term_above_threshold +335,36010,16.89064,0.9970703,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.9614258,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,18.0,18.0,509.58119658119665,2.3458872067348707e-48,Alpha/beta-hydrolase oxyanion-hole loop,True,assigned_too_few_test_positives +336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +337,27733,17.8373,0.8232422,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.61083984,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8400217975166401,0.21393769935365547,0.0101905183872397,0.043478260869565216,20.993799453965234,1.0,19.0,2.8269796111901373,0.46989717992692803,Low-complexity disordered activation regions,True,assigned_and_evaluated +338,84753,16.40112,0.6845703,3.30.420.40,gene3d,84753,3.30.420.40,0.6845703,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,9.0,13.0,286.63942307692304,4.1169917035396624e-21,Helix-dipole oxyanion binding,True,assigned_too_few_test_positives +339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EccB periplasmic aromatic beta-strands,False,no_term_above_threshold +340,49116,24.413357,0.95654297,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.95654297,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9984014209591474,0.5714285714285714,0.002215330084182543,0.8,257.9428571428571,14.0,18.0,67.69618815896189,5.279390681658686e-24,HEAT/ARM alpha-solenoid scaffolds,True,assigned_and_evaluated +341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-binding C-terminal interaction modules,False,no_term_above_threshold +342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic hydrophobic segments,False,no_term_above_threshold +343,52941,20.44419,0.81103516,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.76171875,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,16.0,17.0,245.0387875674287,1.4394641651334948e-37,Hydrophobic MFS transmembrane bundles,True,assigned_too_few_test_positives +344,87970,17.443039,0.8671875,Protein phosphatase,keyword,87970,Protein phosphatase,0.8671875,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,12.0,13.0,265.86845039018954,1.0096389353035879e-28,PTP/DSP phosphatase superfamily,True,assigned_too_few_test_positives +345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-centered hinge/kink motifs,False,no_term_above_threshold +346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid helical scaffolds,False,no_term_above_threshold +347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding catalytic loops,False,no_term_above_threshold +348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular Ser/Thr-rich disordered linkers,False,no_term_above_threshold +349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycine-rich binding pockets,False,no_term_above_threshold +350,50806,18.733797,0.9951172,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9765625,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,10.0,0.0,1.0,HTH recognition helix cap,True,assigned_too_few_test_positives +351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine rich membrane translocation domains,False,no_term_above_threshold +352,50338,18.327742,0.86328125,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.86328125,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,PAS/LOV sensory domain cores,True,assigned_too_few_test_positives +353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Assembly/oligomerization interface regions,False,no_term_above_threshold +354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic permease transmembrane helices,False,no_term_above_threshold +355,85364,17.874355,0.76708984,Periplasmic binding protein-like II,gene3d,64146,Winged helix-like DNA-binding domain superfamily,0.68115234,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,14.0,16.0,263.47664141414145,6.680700659873772e-33,HTH interdomain hinge linker,True,assigned_too_few_test_positives +356,49045,16.157177,0.9975586,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.89746094,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,15.0,19.0,427.9019138755981,9.095357881612513e-38,Beta-propeller loop hotspots,True,assigned_too_few_test_positives +357,84991,16.135086,0.9995117,3.30.70.20,gene3d,36409,"Zinc finger, CCCH-type",0.9848633,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,17.0,19.0,620.2919216646267,4.30976115406328e-46,Ferredoxin Fe–S cluster binding,True,assigned_too_few_test_positives +358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter transmembrane helices,False,no_term_above_threshold +359,46277,15.724642,0.9008789,"Nucleic acid-binding, OB-fold",interpro,87697,Knottin,0.7866211,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9634501740467902,0.16740853770263747,0.004873726185201595,0.09090909090909091,34.34918814498662,6.0,14.0,80.60522757999098,1.3188243766383324e-10,VGD valine beta-strand motif,True,assigned_and_evaluated +360,36914,21.13676,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.99902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,15.0,18.0,613.3847736625514,1.8486169562920046e-40,Glycosyltransferase N-terminal low-complexity linker,True,assigned_too_few_test_positives +361,64620,16.268177,0.9785156,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.9785156,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,17.0,324.0271739130435,1.225281491287518e-42,DHp H-box phosphohistidine,True,assigned_too_few_test_positives +362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM3-adjacent cytoplasmic motif,False,no_term_above_threshold +363,38890,26.704014,0.9794922,HNH nuclease,interpro,38890,HNH nuclease,0.9794922,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,8.0,19.0,545.7299771167048,1.3107251328244467e-20,Cationic Gly/His nucleic-acid loops,True,assigned_too_few_test_positives +364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cobalamin amidotransferase motif,False,no_term_above_threshold +365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UROS and cofactor biosynthesis,False,no_term_above_threshold +366,85656,24.333982,0.6508789,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.6508789,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.6408253968253967,0.2165010443698968,0.0031014621178555605,0.2857142857142857,69.80612244897958,14.0,14.0,141.281990521327,2.4550488164569493e-30,Serine acyl hydrolases,True,assigned_and_evaluated +367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF transition-state stabilizer motif,False,no_term_above_threshold +368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early membrane-anchoring helices,False,no_term_above_threshold +369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted toxin/effector catalytic loops,False,no_term_above_threshold +370,36668,24.920544,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9868164,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,13.0,13.0,532.3303571428571,9.561000563003835e-36,ANL AMP-binding core,True,assigned_too_few_test_positives +371,87326,20.96817,0.6582031,Coiled coil,keyword,87326,Coiled coil,0.6582031,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7131307268128861,0.15344375121095838,0.03943287549844927,0.02247191011235955,3.8912645672262145,13.0,18.0,9.105436902328423,6.046143033298259e-11,Charged low-complexity helical regions,True,assigned_and_evaluated +372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho/sulfate metalloenzyme nucleophile loop,False,no_term_above_threshold +373,63831,19.853727,0.9692383,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9692383,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9925218421442321,0.32471001221001217,0.002658396101019052,0.3333333333333333,122.1450829263329,0.0,15.0,0.0,1.0,Noncatalytic surface loop connectors,True,assigned_and_evaluated +374,64058,16.788801,0.79785156,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7910156,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9181103114451309,0.06239087462945035,0.006202924235711121,,10.058300288476389,0.0,16.0,0.0,1.0,Glycine-rich phosphate-binding loops,True,assigned_and_evaluated +375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical nucleic acid contacts,False,no_term_above_threshold +376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue TM interface motifs,False,no_term_above_threshold +377,45289,16.224882,0.859375,Dimeric alpha-beta barrel,interpro,36354,RNA recognition motif domain,0.67333984,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,0.0,17.0,0.0,1.0,N-terminal catalytic beta-strand,True,assigned_too_few_test_positives +378,85656,16.378887,0.65966797,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.65966797,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.557968253968254,0.0060597566452367385,0.0031014621178555605,,1.953838678328474,6.0,12.0,70.6409952606635,2.26831441226078e-10,Secreted hydrolase gating loops,True,assigned_and_evaluated +379,87697,18.97834,0.84814453,Knottin,keyword,87413,Disulfide bond,0.62939453,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8348188481191187,0.04846722312916721,0.017279574656623838,,2.8048851949366767,0.0,18.0,0.0,1.0,Beta-strand residue detector,True,assigned_and_evaluated +380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap/loop motif,False,no_term_above_threshold +381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic extracytosolic loop-helix,False,no_term_above_threshold +382,88058,86.4463,0.88964844,Signal,keyword,88058,Signal,0.88964844,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9161668710030153,0.6450468998995954,0.09127159946832078,0.883495145631068,7.067334238220324,19.0,19.0,7.204954682779456,1.200803819710704e-16,Sec signal peptide h-region,True,assigned_and_evaluated +383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic ester catalytic loop,False,no_term_above_threshold +384,82029,30.271334,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9946289,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,TM helix termini and hinges,True,assigned_too_few_test_positives +385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein soluble domains,False,no_term_above_threshold +386,37468,17.643005,0.7006836,"Zinc finger, RING-type",interpro,37468,"Zinc finger, RING-type",0.7006836,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,15.0,0.0,1.0,Metal-binding catalytic enzyme cores,True,assigned_too_few_test_positives +387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LexA linker proline motif,False,no_term_above_threshold +388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix boundaries and low-complexity linkers,False,no_term_above_threshold +389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel signature,False,no_term_above_threshold +390,50338,18.199009,0.92578125,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.83496094,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Juxtamembrane helix–loop interface,True,assigned_too_few_test_positives +391,87276,28.365665,0.6020508,Cell membrane,keyword,25079,plasma membrane,0.60009766,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7181821070652584,0.4388243613659124,0.11120957022596367,0.4860557768924303,3.945922643836113,15.0,20.0,6.154108175061933,3.395022273735246e-10,Transmembrane loop-helix junctions,True,assigned_and_evaluated +392,38654,23.188154,0.9941406,B3 DNA binding domain,interpro,25169,pilus,0.8959961,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,TGF-beta prodomain LAP arm,True,assigned_too_few_test_positives +393,52940,16.047302,0.9995117,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.9316406,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,20.0,0.0,1.0,Nucleotide binding loops and termini,True,assigned_too_few_test_positives +394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nitroreductase FMN active-site region,False,no_term_above_threshold +395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-P-loop switch/dimerization module,False,no_term_above_threshold +396,38873,18.125216,0.9707031,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.8520508,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9984902309058614,0.6515262515262515,0.002215330084182543,0.4,294.09894993894994,15.0,15.0,171.32471264367817,1.0841831409947753e-33,ABC NBD D-loop–helix junction,True,assigned_and_evaluated +397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended ligand/cofactor pore-lining catalytic surfaces,False,no_term_above_threshold +398,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PCMH FAD-binding motif,False,no_term_above_threshold +399,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved His-adjacent loop motifs,False,no_term_above_threshold +400,85664,23.85626,0.98876953,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98876953,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,NDP-sugar GT-B interdomain loop,True,assigned_too_few_test_positives +401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-hexoside binding loop motif,False,no_term_above_threshold +402,47529,16.121284,0.6850586,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6850586,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6171630968317715,0.12979595886870476,0.007089056269384138,0.125,18.309342447916666,13.0,20.0,50.264137483787295,4.7446120074508906e-20,Calx-β/Ig-like β-sandwich repeats,True,assigned_and_evaluated +403,88161,39.277164,0.6098633,Transmembrane helix,keyword,88161,Transmembrane helix,0.6098633,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6223999061620269,0.3423817933208677,0.1847585290208241,0.30935251798561153,1.8531311931059915,20.0,20.0,5.4274920345926265,4.680596445535425e-15,Cytosolic juxtamembrane stalks,True,assigned_and_evaluated +404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic N-terminal docking patch,False,no_term_above_threshold +405,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EF-Ts-like assembly interfaces,False,no_term_above_threshold +406,85672,23.305271,0.8300781,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8232422,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8713604982740507,0.1206138633231567,0.01595037660611431,,7.561819153343463,6.0,14.0,17.14889741131352,1.1775188090108078e-06,Conserved catalytic GTPase motif,True,assigned_and_evaluated +407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FMNylated RnfG/NqrC subunits,False,no_term_above_threshold +408,88147,16.108992,0.6958008,Toxin-antitoxin system,keyword,88147,Toxin-antitoxin system,0.6958008,120,keywords,Toxin-antitoxin system,keyword:keywords:Toxin-antitoxin system,10.0,2257.0,0.6685803293279928,0.018675557784732663,0.004430660168365086,,4.215073392014163,0.0,20.0,0.0,1.0,Actinobacterial hydrophobic/basic helices,True,assigned_and_evaluated +409,88161,32.397785,0.67285156,Transmembrane helix,keyword,88161,Transmembrane helix,0.67285156,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7458580961317902,0.4454099386150947,0.1847585290208241,0.29256594724220625,2.410767941137335,11.0,15.0,3.9801608253679257,1.0161101621098692e-05,Hydrophobic transmembrane alpha-helices and boundaries,True,assigned_and_evaluated +410,88263,41.097336,0.95214844,Zinc-finger,keyword,29166,zinc ion binding,0.9140625,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9751675931981687,0.22478147571491064,0.014621178555604785,,15.373690626925859,9.0,18.0,13.029064685314685,1.2745625419401933e-08,Acidic/proline-rich SLiMs,True,assigned_and_evaluated +411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,YjeF_N-associated NAD(P)HX repair,False,no_term_above_threshold +412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered regions and micropeptides,False,no_term_above_threshold +413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TolC-family equatorial extracellular loop,False,no_term_above_threshold +414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Divalent-metal helix-loop-helix motifs,False,no_term_above_threshold +415,85656,23.57363,0.9511719,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.9511719,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9885079365079366,0.127689090139101,0.0031014621178555605,,41.17061092056443,0.0,18.0,0.0,1.0,Glycosyltransferase catalytic loop,True,assigned_and_evaluated +416,63831,19.009638,0.9892578,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9892578,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9995557529986672,0.8722222222222221,0.002658396101019052,1.0,328.1009259259259,16.0,19.0,206.61381849685944,1.7979644410518218e-35,Helix N-cap initiator detector,True,assigned_and_evaluated +417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal chromophore/partner-binding helix,False,no_term_above_threshold +418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding and catalytic hotspots,False,no_term_above_threshold +419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mur-ligase-like catalytic core,False,no_term_above_threshold +420,84879,16.31841,0.81152344,"Histidine kinase-like ATPase, C-terminal domain",gene3d,84879,"Histidine kinase-like ATPase, C-terminal domain",0.81152344,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,18.0,18.0,327.5879120879121,4.6260328382218484e-45,Histidine phosphotransfer helical core,True,assigned_too_few_test_positives +421,88207,17.041033,0.7763672,Viral genome ejection through host cell envelope,keyword,88207,Viral genome ejection through host cell envelope,0.7763672,36,keywords,Viral genome ejection through host cell envelope,keyword:keywords:Viral genome ejection through host cell envelope,,,,,,,,10.0,18.0,372.16604244694133,4.1595864185953795e-24,Pore-forming helices and acidic motifs,True,assigned_too_few_test_positives +422,84152,19.876642,0.7792969,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.7792969,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,2.0,15.0,74.99496855345912,0.0005794713732629119,Early zinc dipeptidase catalytic motif,True,assigned_too_few_test_positives +423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic metal/redox domains,False,no_term_above_threshold +424,36886,19.695448,0.9902344,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9902344,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9334982214317473,0.6376454469692175,0.003544528134692069,0.875,179.89572172619052,17.0,17.0,233.80784313725488,2.75549142438941e-40,Fungal MHR regulatory helices,True,assigned_and_evaluated +425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting signals,False,no_term_above_threshold +426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter NBD detector,False,no_term_above_threshold +427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic low-complexity regions,False,no_term_above_threshold +428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gram-negative outer-membrane pore complexes,False,no_term_above_threshold +429,37894,23.479675,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7211914,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR substrate-binding helix,True,assigned_too_few_test_positives +430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail-anchored transmembrane helix,False,no_term_above_threshold +431,64026,18.561796,0.8305664,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.60791016,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9460610099215164,0.038594388189670335,0.002658396101019052,,14.517922357347658,0.0,17.0,0.0,1.0,Transmembrane helix–loop interfaces,True,assigned_and_evaluated +432,63960,28.837679,0.8588867,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.8588867,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,16.0,16.0,193.57467532467533,1.0288461071936617e-36,Rossmann-domain C-terminal helical hotspot,True,assigned_too_few_test_positives +433,59224,28.958027,0.9741211,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9741211,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9984126984126984,0.73562477622628,0.0031014621178555605,0.7142857142857143,237.18644570610198,18.0,18.0,137.37557603686636,1.6332112516921354e-38,Hydrolase charge-relay acidic loop,True,assigned_and_evaluated +434,88160,15.62512,0.87646484,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7338867,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Outer-membrane beta-barrel channels,True,assigned_too_few_test_positives +435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-adjacent aromatic anchor loops,False,no_term_above_threshold +436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic β-strand edge patches,False,no_term_above_threshold +437,88162,17.272295,0.6303711,Transport,keyword,88162,Transport,0.6303711,1387,keywords,Transport,keyword:keywords:Transport,141.0,2257.0,0.7337626861869714,0.14956789058263847,0.06247230837394772,,2.3941470145036527,9.0,15.0,6.811233815689261,1.865801635384991e-06,Short linear helical motifs,True,assigned_and_evaluated +438,88263,17.747124,0.7314453,Zinc-finger,keyword,88263,Zinc-finger,0.7314453,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8665658382385002,0.10401050003395393,0.014621178555604785,,7.113687835655576,7.0,17.0,10.729817976141504,3.21307759294336e-06,Structured interaction domain hotspots,True,assigned_and_evaluated +439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity regions,False,no_term_above_threshold +440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted/extracytosolic remodeling enzymes,False,no_term_above_threshold +441,64016,37.937447,0.92041016,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.9189453,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8534603174603175,0.3961242272717682,0.0031014621178555605,0.7142857142857143,127.72176870748298,12.0,13.0,204.59022018873318,2.3752269866491593e-27,Thioredoxin-like active-site helix,True,assigned_and_evaluated +442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pilin-like C-terminal regions,False,no_term_above_threshold +443,85762,30.420387,0.83154297,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.8198242,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,8.0,8.0,205.58965517241379,7.169600524943691e-19,FAD-dependent monooxygenase core,True,assigned_too_few_test_positives +444,47717,18.133703,0.9501953,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.66796875,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,2.0,12.0,45.58180428134556,0.001510864849213206,Helicase motor-coupling segment,True,assigned_too_few_test_positives +445,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL ATPase charged hinges,False,no_term_above_threshold +446,15821,15.868278,0.66064453,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.66064453,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,10.0,0.0,1.0,Membrane-proximal cytosolic interfaces,True,assigned_too_few_test_positives +447,83419,20.702253,0.9589844,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9453125,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,1.0,17.0,21.38486370157819,0.07560237020184968,Aromatic glycan-binding loops,True,assigned_too_few_test_positives +448,88058,45.542694,0.7832031,Signal,keyword,88058,Signal,0.7832031,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7922479207395872,0.22274006269544588,0.09127159946832078,,2.4404093276874823,3.0,19.0,1.137624423596756,0.7800416838874774,N-terminal leader/targeting segments,True,assigned_and_evaluated +449,85649,18.338663,0.90283203,Vaccinia Virus protein VP39,gene3d,88153,Transferase,0.6694336,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9215873263010393,0.14806689501032513,0.0101905183872397,,14.529868784274079,1.0,13.0,8.508776937348365,0.17965685453583757,Conserved hydrophobic beta-strand scaffold,True,assigned_and_evaluated +450,88058,25.041557,0.64501953,Signal,keyword,88058,Signal,0.64501953,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6617562827510142,0.11952806519833754,0.09127159946832078,,1.3095866172458632,3.0,20.0,1.0807432024169183,0.8334769282943363,Short signal/disordered microproteins,True,assigned_and_evaluated +451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-binding coupling helices,False,no_term_above_threshold +452,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GSAT-rich linkers and cysteine anchors,False,no_term_above_threshold +453,55054,17.636572,0.9140625,HAD superfamily,interpro,55054,HAD superfamily,0.9140625,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.88050621669627,0.04371418215559971,0.002215330084182543,,19.732581825037713,2.0,15.0,44.65992509363296,0.001596511599149494,NTP phosphate-binding N-cap helix,True,assigned_and_evaluated +454,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal β–α substrate-binding module,False,no_term_above_threshold +455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coatomer-like interface scaffolds,False,no_term_above_threshold +456,88252,25.489931,0.98828125,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.984375,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.9989745561750946,0.8524932718127085,0.012405848471422242,1.0,68.7170469457601,8.0,15.0,68.67789776817854,1.722409767731116e-13,WD40 N-terminal helix–strand cap,True,assigned_and_evaluated +457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic TMD loop-helix junctions,False,no_term_above_threshold +458,38873,18.805447,0.9873047,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95458984,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9993783303730017,0.8253968253968254,0.002215330084182543,1.0,372.584126984127,14.0,14.0,171.32471264367817,1.6994884608024663e-31,β-strand before Walker A,True,assigned_and_evaluated +459,36115,23.464676,0.9296875,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9082031,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,15.0,0.0,1.0,PAS/LOV beta-sheet motifs,True,assigned_too_few_test_positives +460,64596,15.793409,0.97509766,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,88261,Zinc,0.64990234,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,0.0,7.0,0.0,1.0,Histidine-centered catalytic motifs,True,assigned_too_few_test_positives +461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane glyco/lipid enzyme TMs,False,no_term_above_threshold +462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Actinobacterial post-anchor N-termini,False,no_term_above_threshold +463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HD-domain metal-binding cores,False,no_term_above_threshold +464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global activation with N-terminal peaks,False,no_term_above_threshold +465,36535,16.910818,0.91748047,Protein kinase domain,interpro,47529,Immunoglobulin-like fold,0.9091797,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9396528704939919,0.31523233804748785,0.004430660168365086,0.4,71.14793869731801,0.0,20.0,0.0,1.0,Beta-strand initiation caps,True,assigned_and_evaluated +466,88161,33.92916,0.62060547,Transmembrane helix,keyword,88159,Transmembrane,0.61865234,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6350836721926806,0.32427379629359576,0.1847585290208241,0.23501199040767387,1.7551222020015484,12.0,18.0,3.6183280230617507,1.735602827260488e-05,Hydrophobic membrane-anchoring segments,True,assigned_and_evaluated +467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured cytosolic beta-strand flanks,False,no_term_above_threshold +468,4066,23.273605,0.8823242,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.8823242,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.5940497335701598,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,6.0,20.0,215.4975903614458,5.15182878360807e-13,Noncatalytic domain regional activation,True,assigned_and_evaluated +469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered flexibility motif,False,no_term_above_threshold +470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic and luminal membrane domains,False,no_term_above_threshold +471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting leaders,False,no_term_above_threshold +472,36886,27.939863,0.99853516,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.99853516,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9363328145842597,0.7961275898263603,0.003544528134692069,0.875,224.6074962797619,20.0,20.0,233.80784313725488,6.513624004794376e-47,Activated fungal N-terminal IDRs,True,assigned_and_evaluated +473,88240,17.42749,0.63378906,Virulence,keyword,87522,Glycoprotein,0.60498047,306,keywords,Virulence,keyword:keywords:Virulence,20.0,2257.0,0.7212002682163612,0.11406397451710366,0.008861320336730172,0.1,12.87211952425515,5.0,18.0,9.94678011344678,0.0001943765194474543,Mature extracellular fungal domains,True,assigned_and_evaluated +474,27733,24.704622,0.8691406,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.84375,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.9726752559261999,0.7319593331727272,0.0101905183872397,0.6956521739130435,71.82748760742805,14.0,16.0,46.998536036036036,1.7831858564855874e-22,Disordered TF effector regions,True,assigned_and_evaluated +475,85649,17.098234,0.86376953,Vaccinia Virus protein VP39,gene3d,88153,Transferase,0.66845703,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9170818574598109,0.07307446460117581,0.0101905183872397,,7.17082898281973,0.0,18.0,0.0,1.0,Secondary structure junction linkers,True,assigned_and_evaluated +476,52236,19.6908,0.9897461,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.984375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,18.0,186.08302122347067,1.3855153806489415e-32,TPR A-helix start residue,True,assigned_too_few_test_positives +477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T-rich secretory regions,False,no_term_above_threshold +478,45551,16.946674,0.6845703,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.6845703,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,20.0,0.0,1.0,NB-ARC C-terminal linker,True,assigned_too_few_test_positives +479,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface amphipathic low-complexity repeats,False,no_term_above_threshold +480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase post-core accessory CTD,False,no_term_above_threshold +481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil heptad periodicity signature,False,no_term_above_threshold +482,48883,15.936991,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,16.0,16.0,480.8145161290322,6.075488456631373e-43,Aminotransferase PLP-lysine loop,True,assigned_too_few_test_positives +483,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase substrate-binding loop,False,no_term_above_threshold +484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix/loop capping patches,False,no_term_above_threshold +485,45804,20.612772,0.9951172,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.9848633,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,20.0,20.0,276.02314814814815,3.007358665307739e-48,Two-helix gating in secondary carriers,True,assigned_too_few_test_positives +486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycosylated disulfide domains,False,no_term_above_threshold +487,59211,19.942934,0.7338867,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7338867,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.8996415770609318,0.8022153300841826,0.011076650420912717,0.8,72.42399999999999,13.0,13.0,244.34836065573774,2.670764478308152e-31,Class I nucleotidyltransferase core,True,assigned_and_evaluated +488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OFOR/POR β/α core fold marker,False,no_term_above_threshold +489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytochrome P450 C-terminal meander,False,no_term_above_threshold +490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and pre-TM helices,False,no_term_above_threshold +491,38873,16.519009,0.87646484,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77734375,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8937388987566608,0.30566954685307346,0.002215330084182543,0.4,137.97923344947736,12.0,17.0,120.93509127789048,2.2316418537937037e-23,N-terminal pre-motor coupling linker,True,assigned_and_evaluated +492,36876,16.657936,0.8955078,Cytochrome P450,interpro,36876,Cytochrome P450,0.8955078,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9982700672202451,0.5620650953984286,0.003987594151528578,1.0,140.95343559047262,0.0,19.0,0.0,1.0,HisKA H+4 determinant,True,assigned_and_evaluated +493,52941,16.401672,0.9345703,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.6459961,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,13.0,0.0,1.0,Transporter transmembrane helix faces,True,assigned_too_few_test_positives +494,63831,27.223244,0.9975586,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9975586,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9991115059973344,0.6218253968253968,0.002658396101019052,1.0,233.90998677248677,10.0,20.0,122.6769547325103,4.751715891422786e-19,N-terminal F-box Skp1 interface,True,assigned_and_evaluated +495,85664,16.900513,0.92871094,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.92871094,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,Active-site rim β-strand/loop segments,True,assigned_too_few_test_positives +496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity surface tails,False,no_term_above_threshold +497,36535,20.299116,0.95751953,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9506836,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9487761459724077,0.9004430660168364,0.004430660168365086,0.9,203.23,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Kinase activation-loop terminus helix,True,assigned_and_evaluated +498,87384,17.091307,0.61035156,DNA-binding,keyword,87384,DNA-binding,0.61035156,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.6704744385467276,0.12093117510171886,0.043863535666814356,0.020202020202020204,2.756986486914944,2.0,13.0,1.8846232871299646,0.45107610567781314,Bromodomain and HTH recognition loops,True,assigned_and_evaluated +499,87326,30.292698,0.6303711,Coiled coil,keyword,87326,Coiled coil,0.6303711,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6392496579460177,0.27987881896708433,0.03943287549844927,0.24719101123595505,7.097601060772015,15.0,18.0,10.50627334884049,4.501608829624033e-14,Coiled-coil termini and disordered tails,True,assigned_and_evaluated +500,37097,17.414,0.95214844,Cro/C1-type helix-turn-helix domain,interpro,88009,Repeat,0.60595703,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,16.0,0.0,1.0,Glycine centered hinge loops,True,assigned_too_few_test_positives +501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal anionic-binding hotspots,False,no_term_above_threshold +502,27932,18.922453,0.6176758,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.6044922,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.586277369264265,0.07734640017319051,0.01949490474080638,0.022727272727272728,3.967518754338432,2.0,9.0,23.001929012345677,0.00554632725034678,C-terminal nucleic acid–binding module,True,assigned_and_evaluated +503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane alpha-helix topology signature,False,no_term_above_threshold +504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ICA-adjacent trimeric beta-solenoid,False,no_term_above_threshold +505,48767,25.221323,0.99560547,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99560547,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,20.0,0.0,1.0,SET domain catalytic core,True,assigned_too_few_test_positives +506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop-helix catalytic flanks,False,no_term_above_threshold +507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic amphipathic interface helices,False,no_term_above_threshold +508,38317,19.803566,0.98535156,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.89404297,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9994920634920634,0.827437641723356,0.0031014621178555605,1.0,266.7895367670878,10.0,19.0,202.44821731748726,2.5613317359954077e-21,Helical solenoid turn linkers,True,assigned_and_evaluated +509,72011,19.084398,0.97021484,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.97021484,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,GGDEF-proximal catalytic helix,True,assigned_too_few_test_positives +510,87149,24.840511,0.73095703,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.73095703,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7296753829391783,0.08392500688660902,0.012405848471422242,,6.764955019395591,0.0,18.0,0.0,1.0,Membrane-penetrating hydrophobic helices,True,assigned_and_evaluated +511,37071,18.409409,0.9199219,Homeodomain,interpro,37071,Homeodomain,0.9199219,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,1.0,14.0,14.735788433020266,0.10753607439002937,Terminal functional module emphasis,True,assigned_too_few_test_positives +512,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short functional domain segments,False,no_term_above_threshold +513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary caps,False,no_term_above_threshold +514,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic nucleic-acid-binding surfaces,False,no_term_above_threshold +515,59211,19.37089,0.91308594,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.91308594,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9999820788530466,0.9984615384615385,0.011076650420912717,1.0,90.1411076923077,16.0,16.0,244.34836065573774,2.609530204638983e-38,Nucleotide-sugar phosphate-binding loop,True,assigned_and_evaluated +516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminus-biased methionine detector,False,no_term_above_threshold +517,87697,21.95498,0.9296875,Knottin,keyword,87413,Disulfide bond,0.7675781,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9601165290975932,0.1717760318594121,0.017279574656623838,,9.940987279658797,0.0,10.0,0.0,1.0,Extracellular cysteine-rich repeats,True,assigned_and_evaluated +518,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanionic polysaccharide CAZyme cores,False,no_term_above_threshold +519,63774,17.690975,0.9658203,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.96240234,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,14.0,0.0,1.0,Alpha-beta junction beta-strand starters,True,assigned_too_few_test_positives +520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop junctions,False,no_term_above_threshold +521,15821,18.59982,0.6904297,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6904297,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,14.0,0.0,1.0,Charged low-complexity IDRs,True,assigned_too_few_test_positives +522,69093,15.749709,0.9404297,"ANL, N-terminal domain",interpro,85682,NAD(P)-binding Rossmann-like Domain,0.78125,40,ip,IPR042099,interpro:ip:IPR042099,,,,,,,,0.0,13.0,0.0,1.0,PBP-like clamshell LBDs,True,assigned_too_few_test_positives +523,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal and juxtamembrane stalks,False,no_term_above_threshold +524,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal core-adjacent segments,False,no_term_above_threshold +525,85682,16.143753,0.8598633,NAD(P)-binding Rossmann-like Domain,gene3d,88153,Transferase,0.6640625,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9455017921146953,0.11290270292403246,0.011076650420912717,,10.19285601998165,0.0,15.0,0.0,1.0,Basic polyanion-binding patches,True,assigned_and_evaluated +526,35176,16.151484,0.88427734,protein serine kinase activity,go_mf,45290,Protein kinase-like domain superfamily,0.8339844,66,go,GO:0106310,go_mf:go:GO:0106310,6.0,2257.0,0.9954834888197838,0.2523809523809524,0.002658396101019052,,94.93730158730158,13.0,14.0,98.50953228266395,1.7272479963172375e-25,Broad domain-and-IDR kinase activation,True,assigned_and_evaluated +527,46274,17.94815,0.9086914,Ribonuclease H-like superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9086914,72,ip,IPR012337,interpro:ip:IPR012337,38.0,2257.0,0.969213253955077,0.22579904501835957,0.016836508639787327,,13.411274858064147,0.0,17.0,0.0,1.0,Active-site-proximal Gly/Ser loops,True,assigned_and_evaluated +528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass lipid enzyme TM cores,False,no_term_above_threshold +529,25169,17.50211,0.8745117,pilus,go_cc,47529,Immunoglobulin-like fold,0.81103516,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.997202486678508,0.40263157894736845,0.002215330084182543,0.6,181.74789473684214,0.0,19.0,0.0,1.0,Aromatic-adjacent acidic loop motifs,True,assigned_and_evaluated +530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tandem repeat and linker detector,False,no_term_above_threshold +531,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA/tRNA-binding and adenylate-forming enzymes,False,no_term_above_threshold +532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zincin propeptide N-terminal region,False,no_term_above_threshold +533,37894,19.373526,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8354492,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,7.0,709.7738095238095,2.2341786607428882e-20,SDR cofactor pocket helix,True,assigned_too_few_test_positives +534,88161,27.235027,0.6411133,Transmembrane helix,keyword,88161,Transmembrane helix,0.6411133,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7326132572203107,0.4598238051954854,0.1847585290208241,0.486810551558753,2.4887825619333586,8.0,14.0,3.101424019767215,0.0023974917011427357,TM caps and uS13m motif,True,assigned_and_evaluated +535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic nucleotidyltransferase catalytic motifs,False,no_term_above_threshold +536,81858,17.579445,0.9145508,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6699219,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,1.0,15.0,17.433040935672516,0.09189417910448792,Generic hydrophobic TM helix,True,assigned_too_few_test_positives +537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored pocket-lid helix,False,no_term_above_threshold +538,64620,17.347582,0.8984375,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.8984375,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,Pre-HisKA S-helix linker,True,assigned_too_few_test_positives +539,81799,18.724009,0.9814453,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,10.0,12.0,482.3705501618123,3.148521085966243e-26,AAA+ sensor-2 switch,True,assigned_too_few_test_positives +540,85672,18.658617,0.65966797,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.65966797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5638351093101206,0.06916067271399365,0.01595037660611431,0.027777777777777776,4.335989953207879,15.0,17.0,35.30655349388078,3.0965937321674366e-22,Helical C-terminal interaction domains,True,assigned_and_evaluated +541,81685,23.053205,0.96484375,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9638672,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9554194506310318,0.9171097326835032,0.005316792202038104,0.9166666666666666,172.49305555555554,16.0,16.0,85.66235632183908,4.040725274098586e-31,HRD-adjacent catalytic loop,True,assigned_and_evaluated +542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartokinase helix C-cap motif,False,no_term_above_threshold +543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PRTase PRPP-binding loop-core,False,no_term_above_threshold +544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop-beta capping motif,False,no_term_above_threshold +545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metalloprotease active-site loop,False,no_term_above_threshold +546,87913,15.764706,0.83935547,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.83935547,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8345009871982677,0.07587584880560176,0.006202924235711121,,12.232270768160227,0.0,16.0,0.0,1.0,MobA-like NTase NTP-binding loop,True,assigned_and_evaluated +547,10589,16.692186,0.7109375,photosynthesis,go_bp,10589,photosynthesis,0.7109375,144,go,GO:0015979,go_bp:go:GO:0015979,22.0,2257.0,0.830008135041692,0.24710517305042234,0.00974745237040319,0.09090909090909091,25.35074434430924,0.0,16.0,0.0,1.0,Hydrophobic transmembrane helix cores,True,assigned_and_evaluated +548,85664,16.715977,0.96875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.96875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,9.0,16.0,186.315625,4.849533621176024e-19,Catalytic beta-strand hotspots,True,assigned_too_few_test_positives +549,49230,33.507862,0.9995117,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.9995117,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,12.0,13.0,259.5979680696662,1.3406012603263004e-28,Terminal acceptor-binding subdomain,True,assigned_too_few_test_positives +550,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic lysine-rich disordered patches,False,no_term_above_threshold +551,63831,19.490816,0.9848633,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9848633,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9898563601362358,0.1937365626631163,0.002658396101019052,,72.87723698844225,0.0,16.0,0.0,1.0,Charged helix-loop junction motifs,True,assigned_and_evaluated +552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-transfer scaffolds and hotspots,False,no_term_above_threshold +553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-NTPase regulatory regions,False,no_term_above_threshold +554,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sliding clamp fold detector,False,no_term_above_threshold +555,49236,16.991707,0.9633789,C-type lectin fold,interpro,49236,C-type lectin fold,0.9633789,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.989076376554174,0.20147286433000722,0.002215330084182543,,90.94485095856527,0.0,18.0,0.0,1.0,SLH cell-wall anchoring repeats,True,assigned_and_evaluated +556,88161,30.671556,0.64453125,Transmembrane helix,keyword,88159,Transmembrane,0.6435547,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6138606506099468,0.2826061752491143,0.1847585290208241,0.0407673860911271,1.5295974521277003,18.0,20.0,4.884742831133364,1.6557020938606967e-11,Membrane helix boundary recognition,True,assigned_and_evaluated +557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Radical SAM C-terminal junction,False,no_term_above_threshold +558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical interaction stalks,False,no_term_above_threshold +559,87276,29.361668,0.64746094,Cell membrane,keyword,88161,Transmembrane helix,0.6303711,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6438225165142025,0.2832937767463761,0.11120957022596367,0.16733067729083664,2.547386669787135,8.0,12.0,5.470318377832829,2.8247377570177352e-05,Transmembrane helix exit motif,True,assigned_and_evaluated +560,36914,15.877545,0.98583984,Glycosyltransferase 2-like,interpro,36354,RNA recognition motif domain,0.90478516,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,9.0,0.0,1.0,ABC A-loop adenine-stacking residue,True,assigned_too_few_test_positives +561,83267,26.073196,0.99609375,DNA-binding pseudobarrel domain,gene3d,48767,DNA-binding pseudobarrel domain superfamily,0.99560547,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,16.0,0.0,1.0,Histone lysine modification catalytic cores,True,assigned_too_few_test_positives +562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP-adjacent beta-strand block,False,no_term_above_threshold +563,59229,16.901838,0.8227539,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,88153,Transferase,0.64501953,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9152037678564479,0.11833206099239016,0.0101905183872397,,11.611976593905416,0.0,19.0,0.0,1.0,Active-site loop/turn residues,True,assigned_and_evaluated +564,49121,16.293476,0.80566406,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.80566406,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,9.0,0.0,1.0,Hydrophobic regulatory micro-sites,True,assigned_too_few_test_positives +565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-site adjacent beta-strand,False,no_term_above_threshold +566,82029,18.279303,0.77490234,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.7636719,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,4.0,19.0,39.595550390171006,5.4065778119213196e-06,Cytosolic TM helix exits,True,assigned_too_few_test_positives +567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/aromatic-rich interaction SLiMs,False,no_term_above_threshold +568,48241,19.58545,0.98535156,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.98535156,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,17.0,17.0,387.14935064935065,6.892595500529335e-44,DSBH/cupin pocket beta-strand motif,True,assigned_too_few_test_positives +569,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic charged helical scaffolds,False,no_term_above_threshold +570,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor carriers and acidic stalks,False,no_term_above_threshold +571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich linkers and caps,False,no_term_above_threshold +572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking helices,False,no_term_above_threshold +573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS sensory/dimerization domains,False,no_term_above_threshold +574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interaction helix,False,no_term_above_threshold +575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structured interaction core,False,no_term_above_threshold +576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Spike/adhesin assembly modules,False,no_term_above_threshold +577,38873,18.919704,0.98828125,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.953125,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9992451154529307,0.8166666666666667,0.002215330084182543,0.8,368.6433333333334,16.0,16.0,171.32471264367817,7.059051418617812e-36,ABC ATPase Walker A motif,True,assigned_and_evaluated +578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate binding active site loops,False,no_term_above_threshold +579,24974,16.622335,0.7426758,nucleolus,go_cc,88020,Ribonucleoprotein,0.65234375,141,go,GO:0005730,go_cc:go:GO:0005730,12.0,2257.0,0.7290645879732739,0.13718741910951968,0.005316792202038104,0.08333333333333333,25.80266707751549,19.0,20.0,38.82107607950651,1.5634117498575206e-29,Terminal polyampholytic RNA-binding IDRs,True,assigned_and_evaluated +580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Toxin membrane translocation helix,False,no_term_above_threshold +581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anchoring transmembrane helix,False,no_term_above_threshold +582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass TM helix-loop hotspot,False,no_term_above_threshold +583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asp-biased disordered region detector,False,no_term_above_threshold +584,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding enzyme catalytic cores,False,no_term_above_threshold +585,38654,19.891312,0.9550781,B3 DNA binding domain,interpro,46277,"Nucleic acid-binding, OB-fold",0.8125,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,19.0,0.0,1.0,OB-fold nucleic acid binders,True,assigned_too_few_test_positives +586,37430,15.697334,1.0,"Signal transduction response regulator, receiver domain",interpro,85649,Vaccinia Virus protein VP39,0.80566406,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,18.0,18.0,484.7235772357723,5.774267819403017e-48,Amphipathic REC alpha1 helix,True,assigned_too_few_test_positives +587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C/PPM catalytic domain,False,no_term_above_threshold +588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mobile-element acidic disordered linkers,False,no_term_above_threshold +589,85672,30.81114,0.6777344,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6699219,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6730639351643404,0.2112639444353108,0.01595037660611431,0.3055555555555556,13.245075627513792,14.0,14.0,40.01409395973155,9.778128717856954e-23,NMP kinase fold module,True,assigned_and_evaluated +590,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular GxF/DGT motif,False,no_term_above_threshold +591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended non-catalytic interface scaffolds,False,no_term_above_threshold +592,46933,16.422295,0.97021484,"Zinc finger, NHR/GATA-type",interpro,29166,zinc ion binding,0.8540039,49,ip,IPR013088,interpro:ip:IPR013088,,,,,,,,0.0,19.0,0.0,1.0,Cys-cluster micro-motifs,True,assigned_too_few_test_positives +593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding motif-flanking helices,False,no_term_above_threshold +594,85791,23.82694,0.90966797,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.90966797,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,11.0,12.0,594.0498188405797,2.9205503512904336e-30,Metallo-beta-lactamase core strand-helix,True,assigned_too_few_test_positives +595,88009,16.687263,0.61865234,Repeat,keyword,88009,Repeat,0.61865234,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6198609185088506,0.12918669768972657,0.07266282676118742,0.018292682926829267,1.7778925407665418,14.0,20.0,6.205903345724907,2.181409304334687e-09,Threonine-centered tandem repeats,True,assigned_and_evaluated +596,3751,15.625886,0.8696289,DNA-directed DNA polymerase,ec,46274,Ribonuclease H-like superfamily,0.6767578,26,ec,2.7.7.7,ec:ec:2.7.7.7,,,,,,,,10.0,15.0,382.1858974358974,1.4843174559910279e-24,Exonuclease-polymerase interface aromatic motif,True,assigned_too_few_test_positives +597,37894,25.188654,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7729492,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR substrate-binding helix,True,assigned_too_few_test_positives +598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV sensory domains,False,no_term_above_threshold +599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse HUH catalytic-domain activation,False,no_term_above_threshold +600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chaperonin equatorial ATP-binding site,False,no_term_above_threshold +601,59229,33.483677,0.984375,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.984375,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8639017554785722,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,15.0,15.0,106.27629233511585,1.2978692612531535e-30,Conserved SAM-MTase core loop,True,assigned_and_evaluated +602,59237,15.78402,0.99609375,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.99609375,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,3.0,18.0,52.29912280701755,4.648982227326668e-05,Acidic strand-loop docking patches,True,assigned_too_few_test_positives +603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved loop-capping residues,False,no_term_above_threshold +604,36010,20.545603,0.9560547,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.8564453,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,3.0,16.0,95.54647435897436,7.642762768217845e-06,Alpha/beta hydrolase C-terminal His subdomain,True,assigned_too_few_test_positives +605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteolipid transmembrane helices,False,no_term_above_threshold +606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass TM helix motifs,False,no_term_above_threshold +607,52236,19.391335,0.98876953,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98095703,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,18.0,173.67748647523928,1.0369554419320324e-29,Alpha-solenoid helix-start marker,True,assigned_too_few_test_positives +608,52236,18.984072,0.9951172,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99072266,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,18.0,210.8940907199334,9.175234661021449e-39,Solenoid repeat boundary linkers,True,assigned_too_few_test_positives +609,38873,15.821055,0.72558594,AAA+ ATPase domain,interpro,30398,ATP hydrolysis activity,0.6875,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7951154529307284,0.42310835425589527,0.002215330084182543,0.4,190.99111111111114,18.0,18.0,171.32471264367817,3.4754519922273606e-40,ABC NBD Q-loop helix,True,assigned_and_evaluated +610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal anchor helix,False,no_term_above_threshold +611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TilS catalytic tRNA-binding core,False,no_term_above_threshold +612,36104,17.774332,1.0,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.99902344,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,18.0,18.0,584.5196078431372,2.8383723847396417e-49,Proline-rich disordered regulatory linkers,True,assigned_too_few_test_positives +613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical interface hotspots,False,no_term_above_threshold +614,48767,16.090729,0.99902344,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.9135742,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,2.0,15.0,124.21041666666666,0.0002147580463863763,Alpha-helix capping motifs,True,assigned_too_few_test_positives +615,82029,25.242222,1.0,MFS general substrate transporter like domains,gene3d,88162,Transport,0.61621094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS TM kink/interface residues,True,assigned_too_few_test_positives +616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic group-binding residues,False,no_term_above_threshold +617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoenzyme N-terminal anchor/stem,False,no_term_above_threshold +618,38873,21.24468,0.9589844,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.92822266,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8925843694493784,0.28390626948003994,0.002215330084182543,0.4,128.15529004329005,12.0,17.0,120.93509127789048,2.2316418537937037e-23,Walker A-adjacent engagement loops,True,assigned_and_evaluated +619,52236,19.267002,0.99072266,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.984375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,16.0,195.38717228464418,4.427938857879054e-31,TPR repeat positional signature,True,assigned_too_few_test_positives +620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane transporter hairpin motif,False,no_term_above_threshold +621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral low-complexity SLiM hotspots,False,no_term_above_threshold +622,61392,22.791615,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.63964844,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,16.0,16.0,167.4747191011236,1.0061157503323576e-35,LRR beta-strand-helix loop,True,assigned_and_evaluated +623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered linkers and hinges,False,no_term_above_threshold +624,37020,16.982494,0.87597656,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.8540039,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,20.0,0.0,1.0,Glycosyltransferase specificity loop,True,assigned_too_few_test_positives +625,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-handling catalytic cores,False,no_term_above_threshold +626,59211,21.616283,0.9897461,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9999820788530466,0.9984615384615385,0.011076650420912717,1.0,90.1411076923077,18.0,18.0,244.34836065573774,7.288942336525665e-43,GxY donor-binding beta-strand loop,True,assigned_and_evaluated +627,88058,19.014956,0.61816406,Signal,keyword,88058,Signal,0.61816406,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.576746839098143,0.1031442393862446,0.09127159946832078,,1.1300803315279324,6.0,20.0,2.1614864048338367,0.08048950337413811,Generic serine detector,True,assigned_and_evaluated +628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered tails in LysM proteins,False,no_term_above_threshold +629,88009,17.428362,0.6074219,Repeat,keyword,88009,Repeat,0.6074219,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7342331581462017,0.31506249928893204,0.07266282676118742,0.3475609756097561,4.3359515908239,8.0,13.0,5.455739205032885,3.6831019044682945e-05,Structured aromatic-Cys/His motifs,True,assigned_and_evaluated +630,85672,23.680124,0.82958984,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8232422,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9106821251688428,0.10355419470852897,0.01595037660611431,,6.492272707143053,2.0,15.0,5.335212527964206,0.08698176689532991,Cofactor binding loop,True,assigned_and_evaluated +631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site helix-loop patches,False,no_term_above_threshold +632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interfaces,False,no_term_above_threshold +633,29104,16.064077,0.75878906,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.60058594,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,13.0,0.0,1.0,Cytosolic interfacial basic loops,True,assigned_too_few_test_positives +634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HEPN R-N-x-x-H active-site motif,False,no_term_above_threshold +635,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich peptide-binding helices,False,no_term_above_threshold +636,48767,22.046322,0.9145508,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9145508,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,15.0,0.0,1.0,PDZ binding groove activation,True,assigned_too_few_test_positives +637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular protease catalytic domains,False,no_term_above_threshold +638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-boundary amphipathic re-entrant helices,False,no_term_above_threshold +639,88160,15.762134,0.8354492,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6899414,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Outer-membrane beta-barrel loops and plugs,True,assigned_too_few_test_positives +640,43624,19.29625,0.8754883,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.8754883,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8491605310129408,0.0381002527388389,0.007089056269384138,,5.374516901972463,6.0,17.0,30.990730312743658,4.7262134384507714e-08,Charged regulatory alpha-helical surfaces,True,assigned_and_evaluated +641,81858,16.32947,0.85009766,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6044922,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Multi-pass glycan-biosynthesis TM helices,True,assigned_too_few_test_positives +642,30856,15.866478,0.80908203,transmembrane transporter activity,go_mf,88162,Transport,0.6035156,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7657637655417407,0.08566090680844779,0.002215330084182543,,38.66733333333333,4.0,16.0,33.49494382022472,9.767795153881004e-06,Hydrophobic transmembrane transporter helices,True,assigned_and_evaluated +643,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended regulatory scaffold regions,False,no_term_above_threshold +644,36886,16.771177,0.76953125,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,82597,Tetratricopeptide repeat domain,0.6982422,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8055246776345043,0.14002820066080246,0.003544528134692069,,39.50545611142889,0.0,19.0,0.0,1.0,Eukaryotic TPR scaffold proteins,True,assigned_and_evaluated +645,85649,28.942886,0.7529297,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7504883,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7156494492234635,0.4237722805791231,0.0101905183872397,0.43478260869565216,41.584958142046986,13.0,13.0,110.61410018552876,7.552885156667182e-27,Rossmann-like SAM-dependent methyltransferases,True,assigned_and_evaluated +646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PDZ-centric C-terminal recognition,False,no_term_above_threshold +647,31094,17.216778,0.95703125,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8261719,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9461059190031152,0.3164032242796264,0.004430660168365086,,71.41220771991169,0.0,15.0,0.0,1.0,N-terminal GATase-II lid signature,True,assigned_and_evaluated +648,88161,34.981987,0.60302734,Transmembrane helix,keyword,88161,Transmembrane helix,0.60302734,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5969821968512147,0.32293716400192196,0.1847585290208241,0.2422062350119904,1.747887719789779,15.0,17.0,4.78896355993467,1.8200329607237112e-09,Membrane interfacial helix start,True,assigned_and_evaluated +649,48767,17.072062,0.9975586,DNA-binding pseudobarrel domain superfamily,interpro,87697,Knottin,0.7758789,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,15.0,0.0,1.0,Active-site proximal loop/strand motifs,True,assigned_too_few_test_positives +650,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central MDR oxidoreductase segment,False,no_term_above_threshold +651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended C-terminal catalytic regions,False,no_term_above_threshold +652,45288,21.047924,0.9375,CheY-like superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.71777344,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,0.0,8.0,0.0,1.0,ABC H-loop catalytic switch,True,assigned_too_few_test_positives +653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC TMD–NBD coupling helix,False,no_term_above_threshold +654,87976,31.182354,0.8666992,Proteomics identification,keyword,87976,Proteomics identification,0.8666992,459,keywords,Proteomics identification,keyword:keywords:Proteomics identification,43.0,2257.0,0.8676130753555598,0.26386866230667283,0.01905183872396987,,13.850036530840944,16.0,20.0,4.618202943454687,3.1759680557547947e-09,Long low-complexity IDRs,True,assigned_and_evaluated +655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal kinase-fold helices,False,no_term_above_threshold +656,88160,17.556463,0.8647461,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7192383,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,12.0,15.0,231.5378640776699,3.09744253716986e-27,Alternating G/S/T beta-strand motif,True,assigned_too_few_test_positives +657,36354,18.550407,0.9995117,RNA recognition motif domain,interpro,64507,Ankyrin repeat-containing domain superfamily,0.81933594,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,17.0,17.0,214.4640287769784,1.128691162273734e-39,RRM/xRRM RNA-binding surface,True,assigned_too_few_test_positives +658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical scaffolds,False,no_term_above_threshold +659,87326,36.99078,0.7680664,Coiled coil,keyword,87326,Coiled coil,0.7680664,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.839840996724574,0.4022875992044874,0.03943287549844927,0.5842696629213483,10.201832712410429,16.0,19.0,10.616865699880913,4.307920495700391e-15,Coiled-coil heptad register,True,assigned_and_evaluated +660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extradiol/MEMO1 C-terminal beta-strand,False,no_term_above_threshold +661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal-anchor N-terminal segment,False,no_term_above_threshold +662,50806,19.13789,0.9970703,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.97314453,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,HTH recognition helix residues,True,assigned_too_few_test_positives +663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-strand/loop patches,False,no_term_above_threshold +664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SF1/SF2 helicase flanking helices,False,no_term_above_threshold +665,38317,16.753525,0.87353516,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.87353516,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7004444444444444,0.03171163111851433,0.0031014621178555605,,10.224735919212405,0.0,20.0,0.0,1.0,Structured scaffold core detector,True,assigned_and_evaluated +666,63831,18.127583,0.65234375,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.65234375,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5638605064415816,0.0048194967508492104,0.002658396101019052,,1.812934027777778,0.0,17.0,0.0,1.0,Helix-helix packing TM segment,True,assigned_and_evaluated +667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional loops and interfaces,False,no_term_above_threshold +668,37314,18.476164,0.9951172,"Helicase, C-terminal domain-like",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9765625,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,10.0,10.0,317.1329787234043,2.3359544982732796e-25,HELICc-C-terminal linker,True,assigned_too_few_test_positives +669,82029,21.700975,0.98876953,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6723633,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,7.0,19.0,69.29221318279926,1.1624047729994863e-11,Permease transmembrane helix boundaries,True,assigned_too_few_test_positives +670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic segment detector,False,no_term_above_threshold +671,86130,16.343576,0.9165039,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9140625,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.994984126984127,0.848499399759904,0.0031014621178555605,0.8571428571428571,273.58044932258616,17.0,17.0,240.4072580645161,1.7442716280492044e-40,C-terminal aromatic activation helix,True,assigned_and_evaluated +672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding surface patch,False,no_term_above_threshold +673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic aliphatic beta-strand motif,False,no_term_above_threshold +674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding lid loops,False,no_term_above_threshold +675,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter transmembrane helices,False,no_term_above_threshold +676,88058,84.442505,0.89697266,Signal,keyword,88058,Signal,0.89697266,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9090711137829997,0.6657685507446703,0.09127159946832078,0.8495145631067961,7.294367082673403,18.0,18.0,7.204954682779456,8.53289450276625e-16,Post-cleavage N-terminal segment,True,assigned_and_evaluated +677,88058,17.826788,0.61035156,Signal,keyword,88058,Signal,0.61035156,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6266999758583309,0.11194834416759378,0.09127159946832078,,1.2265408387682484,3.0,19.0,1.137624423596756,0.7800416838874774,Basic low-complexity disordered regions,True,assigned_and_evaluated +678,88058,24.962175,0.6542969,Signal,keyword,88058,Signal,0.6542969,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6599421073310202,0.11992200972364103,0.09127159946832078,,1.3139027958556204,0.0,20.0,0.0,1.0,Sparse terminal residue peaks,True,assigned_and_evaluated +679,83419,20.42623,0.9628906,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9501953,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,15.0,18.0,302.9522357723577,8.93547183013231e-36,Extracellular beta-sandwich edge patches,True,assigned_too_few_test_positives +680,55054,28.165262,0.9868164,HAD superfamily,interpro,55054,HAD superfamily,0.9868164,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8980017761989343,0.4537763993501699,0.002215330084182543,0.8,204.8346666666667,18.0,18.0,334.9494382022472,3.408992422977286e-45,Post-DxD metal-binding loop,True,assigned_and_evaluated +681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ribokinase-like domain activation,False,no_term_above_threshold +682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered post-cleavage mature residues,False,no_term_above_threshold +683,63831,31.578894,0.98876953,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.98876953,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9994076706648897,0.7027777777777777,0.002658396101019052,1.0,264.36157407407404,13.0,19.0,167.8737275286983,5.352111995025177e-27,F-box–proximal linker/hinge,True,assigned_and_evaluated +684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic scaffold preference,False,no_term_above_threshold +685,37341,31.027464,0.98291016,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9814453,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.998729446935725,0.7955519687914618,0.011962782454585734,1.0,66.5022516134196,0.0,15.0,0.0,1.0,Hydrophobic β-propeller blade strands,True,assigned_and_evaluated +686,58239,24.217339,0.7504883,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7504883,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6635712674785745,0.03526126137406242,0.017722640673460344,,1.9896166730314724,4.0,9.0,15.933988107169103,0.00012438367819944687,Catalytic-border coupling hinges,True,assigned_and_evaluated +687,87366,17.346222,0.79248047,Cytolysis,keyword,87149,Amphibian defense peptide,0.7709961,160,keywords,Cytolysis,keyword:keywords:Cytolysis,10.0,2257.0,0.9419225634178905,0.6462372288432574,0.004430660168365086,0.7,145.8557425499232,11.0,19.0,95.08931419457736,6.855311536922419e-20,Cationic amphipathic helical peptides,True,assigned_and_evaluated +688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic-to-tail transition,False,no_term_above_threshold +689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic S/T/P assembly patches,False,no_term_above_threshold +690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-metabolite enzyme core beta-strands,False,no_term_above_threshold +691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fold-type I ThDP cofactor-binding,False,no_term_above_threshold +692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease interhelical junctions,False,no_term_above_threshold +693,63831,18.035986,0.93408203,F-box-like domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.84033203,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9662002073152673,0.04441584572421066,0.002658396101019052,,16.70776063325724,0.0,16.0,0.0,1.0,Helix-capping repeat boundary motifs,True,assigned_and_evaluated +694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NAELE-like N-terminal acidic patch,False,no_term_above_threshold +695,36499,26.715803,0.9692383,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.9692383,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,16.0,0.0,1.0,Disordered metal-sensing segments,True,assigned_too_few_test_positives +696,50806,23.253265,0.9746094,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9448242,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,C-terminal HTH capping helix,True,assigned_too_few_test_positives +697,45804,17.600643,0.8071289,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.73046875,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,16.0,0.0,1.0,Histidine kinase β–α N-cap,True,assigned_too_few_test_positives +698,46078,16.296186,0.7910156,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.74658203,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,0.0,14.0,0.0,1.0,Alpha-helical binding scaffolds,True,assigned_too_few_test_positives +699,84427,16.619722,0.8574219,Classic Zinc Finger,gene3d,88009,Repeat,0.7558594,118,gene3d,3.30.160.60,gene3d:gene3d:3.30.160.60,9.0,2257.0,0.9796856465005932,0.1284836116920636,0.003987594151528578,,32.220834620998616,4.0,18.0,24.626600578273436,3.3703550027101094e-05,Tandem repeat register detector,True,assigned_and_evaluated +700,46078,19.122503,0.7871094,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.7685547,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,4.0,20.0,26.149561403508773,2.7614496207779947e-05,Extended lipid-binding cores and tails,True,assigned_too_few_test_positives +701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain boundary helix,False,no_term_above_threshold +702,88161,47.588917,0.62353516,Transmembrane helix,keyword,88161,Transmembrane helix,0.62353516,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6272325617766656,0.3770905469405287,0.1847585290208241,0.2973621103117506,2.040991281642142,16.0,16.0,5.4274920345926265,3.815160537588821e-12,Positive-inside juxtamembrane signal-anchor,True,assigned_and_evaluated +703,36354,16.536379,0.73339844,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.7036133,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,13.0,0.0,1.0,GH4 catalytic active-site region,True,assigned_too_few_test_positives +704,48241,25.887684,0.8769531,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.8769531,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,0.0,10.0,0.0,1.0,Metzincin propeptide cysteine-switch,True,assigned_too_few_test_positives +705,87925,15.723382,0.6772461,Plant defense,keyword,87925,Plant defense,0.6772461,171,keywords,Plant defense,keyword:keywords:Plant defense,13.0,2257.0,0.7106471959413135,0.04284009543866757,0.0057598582188746125,,7.437699646544054,1.0,18.0,5.291178558750444,0.27427744753779054,Plant terminal disordered regulatory segments,True,assigned_and_evaluated +706,63951,20.688496,0.98535156,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9404297,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9986654804270463,0.6064925814925816,0.003987594151528578,1.0,152.0948618254174,17.0,17.0,161.13783783783785,1.3433661058868306e-37,Extracellular Ig/FN3 loop interfaces,True,assigned_and_evaluated +707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-capping patches,False,no_term_above_threshold +708,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical bundle interaction domains,False,no_term_above_threshold +709,52941,19.582497,0.8774414,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.78759766,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,17.0,0.0,1.0,Multipass transmembrane and reentrant helices,True,assigned_too_few_test_positives +710,37894,19.180216,0.9790039,Short-chain dehydrogenase/reductase SDR,interpro,64016,Thioredoxin-like superfamily,0.8881836,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,8.0,709.7738095238095,3.1343957826349425e-23,SDR core helix hydrophobes,True,assigned_too_few_test_positives +711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arrestin C-lobe motif,False,no_term_above_threshold +712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early N-terminal activation,False,no_term_above_threshold +713,59224,16.775099,0.94091797,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.94091797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9750476190476192,0.11415172129457843,0.0031014621178555605,,36.80577642312336,3.0,18.0,22.895929339477725,0.000516767009095765,Sparse structured-region motif signal,True,assigned_and_evaluated +714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic packing micro-motifs,False,no_term_above_threshold +715,87729,15.86404,0.62646484,Lipid degradation,keyword,87729,Lipid degradation,0.62646484,68,keywords,Lipid degradation,keyword:keywords:Lipid degradation,,,,,,,,11.0,14.0,176.109291084855,1.1809082257398805e-23,Hydrolase catalytic lid loops,True,assigned_too_few_test_positives +716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact mixed α/β interaction modules,False,no_term_above_threshold +717,64026,16.020535,0.82958984,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.7270508,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.8353694654227751,0.012941483649373517,0.002658396101019052,,4.868154766106004,0.0,18.0,0.0,1.0,Short transmembrane and juxtamembrane helices,True,assigned_and_evaluated +718,29104,15.718085,0.64404297,NADH dehydrogenase (ubiquinone) activity,go_mf,88178,Ubiquinone,0.6401367,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,18.0,0.0,1.0,Transmembrane alpha-helix detector,True,assigned_too_few_test_positives +719,63831,20.664587,0.95654297,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.95654297,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9726047682511476,0.05014469938829309,0.002658396101019052,,18.86276441989625,0.0,8.0,0.0,1.0,Hydrophobic alpha-helical packing residues,True,assigned_and_evaluated +720,27733,20.054077,0.81884766,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.62646484,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8366840527811297,0.38250826377018365,0.0101905183872397,0.30434782608695654,37.53570223170889,16.0,19.0,45.2316737790422,5.207371900949263e-25,Disordered low-complexity activation domains,True,assigned_and_evaluated +721,36876,16.495508,0.9692383,Cytochrome P450,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.66259766,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9972321075523923,0.44376081434904957,0.003987594151528578,1.0,111.28535088731167,0.0,14.0,0.0,1.0,ABC NBD pre-P-loop segment,True,assigned_and_evaluated +722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rieske [2Fe–2S] domain,False,no_term_above_threshold +723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic amphipathic helical repeats,False,no_term_above_threshold +724,45290,22.749947,0.7763672,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7763672,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7264157411216235,0.3275161778369191,0.0057598582188746125,0.3076923076923077,56.861847182917415,11.0,13.0,62.12874194770747,5.394024988109745e-19,Disordered kinase tails and linkers,True,assigned_and_evaluated +725,87326,36.22164,0.7573242,Coiled coil,keyword,87326,Coiled coil,0.7573242,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7729227994527137,0.22969112891795052,0.03943287549844927,0.0449438202247191,5.824863797391172,7.0,15.0,5.883513075350673,0.00013074948662003565,Charged coiled-coil interfaces,True,assigned_and_evaluated +726,37894,17.44925,0.9794922,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8364258,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR PG/APG substrate-positioning loop,True,assigned_too_few_test_positives +727,87697,24.59696,0.7397461,Knottin,keyword,87697,Knottin,0.7397461,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8917481676724237,0.4363053207587747,0.017279574656623838,0.7948717948717948,25.249772024424473,0.0,18.0,0.0,1.0,Gly/Pro-rich low-complexity tracts,True,assigned_and_evaluated +728,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal engagement caps,False,no_term_above_threshold +729,46932,20.178633,0.9584961,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.9584961,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9738762794837561,0.1174738561920718,0.004430660168365086,,26.513849342550607,0.0,12.0,0.0,1.0,Helix N-cap residues,True,assigned_and_evaluated +730,50806,15.985684,0.8847656,"Homeobox, conserved site",interpro,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.7661133,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,1.0,17.0,16.780467210807767,0.09519666082503377,TF regulatory IDRs,True,assigned_too_few_test_positives +731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WH/HTH nucleic-acid binding surface,False,no_term_above_threshold +732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal partner-binding helices,False,no_term_above_threshold +733,46284,27.076918,0.9995117,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9995117,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,11.0,15.0,874.4413333333333,2.4561797627423537e-31,PNPO-like split-barrel fold,True,assigned_too_few_test_positives +734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane flexible linker,False,no_term_above_threshold +735,47529,18.778257,0.91064453,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.91064453,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9678993752788932,0.31819788146233957,0.007089056269384138,0.25,44.885788653781276,4.0,10.0,30.931776913099874,1.0293769723072096e-05,Aromatic edge beta-strand motifs,True,assigned_and_evaluated +736,85649,41.3342,0.9790039,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9760742,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9703787318516213,0.6659632706020487,0.0101905183872397,0.7391304347826086,65.35126529342712,7.0,17.0,45.546982429335365,1.7961997931208598e-10,Class I SAM-dependent methyltransferase domain,True,assigned_and_evaluated +737,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Reelin domain Ser/Thr-His motif,False,no_term_above_threshold +738,87856,15.570063,0.7373047,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7373047,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5804492725757867,0.06567596753032431,0.012405848471422242,0.03571428571428571,5.293952096997928,18.0,19.0,80.23160885167464,1.4161071693999047e-33,Right-hand polymerase catalytic core,True,assigned_and_evaluated +739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane flexible loops,False,no_term_above_threshold +740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tandem structured domain repeats,False,no_term_above_threshold +741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic low-complexity surface loops,False,no_term_above_threshold +742,81540,19.002672,0.94677734,"Tetracycline Repressor, domain 2",gene3d,81540,"Tetracycline Repressor, domain 2",0.94677734,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,1.0,11.0,75.2790404040404,0.022428472723988836,Acidic Mg2+-dependent phosphate module,True,assigned_too_few_test_positives +743,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity C-terminal tails,False,no_term_above_threshold +744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact nucleic‑acid binding/catalytic motifs,False,no_term_above_threshold +745,45290,32.088715,0.97265625,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97265625,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9595159742218565,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,19.0,19.0,73.42487684729065,1.537287712313484e-35,HRD-DKP kinase catalytic loop,True,assigned_and_evaluated +746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GspF/PilC amphipathic helices,False,no_term_above_threshold +747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad domain spanning activation,False,no_term_above_threshold +748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SDR substrate-binding loop,False,no_term_above_threshold +749,49230,32.20318,0.9638672,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.9638672,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,15.0,17.0,248.14511653718088,7.576046114103452e-35,GNAT/NMT C-terminal activation,True,assigned_too_few_test_positives +750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-linker interaction regions,False,no_term_above_threshold +751,84879,15.657106,0.9121094,"Histidine kinase-like ATPase, C-terminal domain",gene3d,84879,"Histidine kinase-like ATPase, C-terminal domain",0.9121094,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,16.0,16.0,327.5879120879121,2.5632456510552033e-40,Histidine kinase HATPase_c motifs,True,assigned_too_few_test_positives +752,36091,17.315626,1.0,GNAT domain,interpro,85712,3.40.630.30,0.98046875,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,GNAT CoA-binding catalytic loop,True,assigned_too_few_test_positives +753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase aromatic hotspots,False,no_term_above_threshold +754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter/channel cytosolic C-terminal tails,False,no_term_above_threshold +755,85672,27.805359,0.671875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.66503906,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6764282855570564,0.28352975374693545,0.01595037660611431,0.25,17.77574039463426,14.0,14.0,40.01409395973155,9.778128717856954e-23,P-loop NTPase C-terminal accessory helices,True,assigned_and_evaluated +756,87198,16.413408,0.7626953,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.7626953,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,5.0,17.0,213.84863701578192,5.6692079294630094e-11,Polar low-complexity segments,True,assigned_too_few_test_positives +757,87326,30.120974,0.66845703,Coiled coil,keyword,87326,Coiled coil,0.66845703,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6478968862722334,0.21813733646194264,0.03943287549844927,0.2696629213483146,5.531864813422523,17.0,20.0,10.716398815817298,4.0926532616225416e-16,Phospho-rich disordered regulatory tails,True,assigned_and_evaluated +758,46081,15.844876,0.9770508,EF-hand domain pair,interpro,46081,EF-hand domain pair,0.9770508,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.9825477990217875,0.269892788084328,0.003544528134692069,,76.14350283829103,,,,,Helical hydrophobe packing signal,True,assigned_and_evaluated +759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil dimerization scaffolds,False,no_term_above_threshold +760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue alpha/beta cores,False,no_term_above_threshold +761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal CH/DCX cytoskeleton-binding,False,no_term_above_threshold +762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich active-site loops,False,no_term_above_threshold +763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich anion-binding loops,False,no_term_above_threshold +764,39177,16.464474,0.99560547,Fibronectin type III,interpro,47529,Immunoglobulin-like fold,0.9682617,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,17.0,17.0,292.2598039215686,6.741542185783814e-42,Aromatic beta-sandwich signature,True,assigned_too_few_test_positives +765,55054,19.093876,0.78564453,HAD superfamily,interpro,55054,HAD superfamily,0.78564453,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.5939609236234458,0.0684389307340127,0.002215330084182543,,30.893333333333338,0.0,17.0,0.0,1.0,PIN/NYN RNase C-terminal/linker regions,True,assigned_and_evaluated +766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered terminal linkers,False,no_term_above_threshold +767,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory glycan catalytic loops,False,no_term_above_threshold +768,80926,30.156162,0.9736328,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.94628906,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.9366001645413411,0.13447366697455204,0.0057598582188746125,,23.346697412427996,7.0,19.0,35.14501052631579,1.2584089202410726e-09,HTH/Myb/SANT recognition helices,True,assigned_and_evaluated +769,85762,31.275425,0.8701172,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.85498047,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,19.0,19.0,205.58965517241379,1.005974624312525e-43,Rossmann-like FAD/NAD binding pocket,True,assigned_too_few_test_positives +770,59237,15.808987,0.9560547,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.9560547,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,0.0,19.0,0.0,1.0,Non-TM buried hydrophobic cores,True,assigned_too_few_test_positives +771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-strand domain cores,False,no_term_above_threshold +772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal hydrophobic structural segments,False,no_term_above_threshold +773,84152,16.538645,0.97021484,Metal-dependent hydrolases,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.73583984,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,11.0,0.0,1.0,D/E-rich active-site clusters,True,assigned_too_few_test_positives +774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal adenosyl-cofactor patch,False,no_term_above_threshold +775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine-rich phosphoregulatory IDRs,False,no_term_above_threshold +776,63892,18.336285,0.95214844,Fibronectin type III superfamily,interpro,47529,Immunoglobulin-like fold,0.69873047,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,14.0,19.0,213.25855901890645,9.896550942132325e-31,FNIII with Pro-rich linkers,True,assigned_too_few_test_positives +777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PsbP N-terminal ANVFGK motif,False,no_term_above_threshold +778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LpxC mid-domain motif,False,no_term_above_threshold +779,88240,16.8568,0.6191406,Virulence,keyword,88240,Virulence,0.6191406,306,keywords,Virulence,keyword:keywords:Virulence,20.0,2257.0,0.7337282074206527,0.08440061831479381,0.008861320336730172,,9.524609776824482,0.0,20.0,0.0,1.0,Ser/Thr-rich acidic repeats,True,assigned_and_evaluated +780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical oligomerization interfaces,False,no_term_above_threshold +781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,POTRA beta-strand activation,False,no_term_above_threshold +782,37341,23.710403,0.9975586,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9926758,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9996844378010298,0.962322117417233,0.011962782454585734,1.0,80.4430007040998,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 strand-loop hinge motif,True,assigned_and_evaluated +783,58239,17.890244,0.69677734,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.69677734,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7494361750112765,0.06805421199059368,0.017722640673460344,,3.8399589115692487,2.0,11.0,6.518449680205543,0.0599712838762773,Catalytic core acidic patch,True,assigned_and_evaluated +784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amide hydrolase pocket scaffold,False,no_term_above_threshold +785,37640,30.314955,0.97558594,EF-hand domain,interpro,46081,EF-hand domain pair,0.9604492,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,13.0,18.0,216.37995533221664,1.2612068461381496e-28,Acidic Ca2+-binding repeat motifs,True,assigned_too_few_test_positives +786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact helical/loop activation blocks,False,no_term_above_threshold +787,88058,33.938187,0.7080078,Signal,keyword,88058,Signal,0.7080078,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7115153394271325,0.14048886249648973,0.09127159946832078,,1.5392396245367832,3.0,20.0,1.0807432024169183,0.8334769282943363,Basic disordered microprotein regions,True,assigned_and_evaluated +788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic short β-strands,False,no_term_above_threshold +789,85664,16.073858,0.6699219,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.6699219,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,16.0,17.0,311.7437908496732,3.142517052007299e-39,NDP-sugar glycosyltransferase core,True,assigned_too_few_test_positives +790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short sensory allosteric helix,False,no_term_above_threshold +791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered linkers/tails,False,no_term_above_threshold +792,85649,15.596915,0.86816406,Vaccinia Virus protein VP39,gene3d,87413,Disulfide bond,0.63134766,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.869798762212448,0.22939095570122175,0.0101905183872397,0.08695652173913043,22.51023421815902,2.0,20.0,11.061410018552875,0.02359891658202867,Short solvent exposed loops,True,assigned_and_evaluated +793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine-rich IDR linkers,False,no_term_above_threshold +794,85672,37.72304,0.95410156,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.94140625,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9329631297213468,0.6645893371983915,0.01595037660611431,0.8055555555555556,41.66605927935471,16.0,16.0,40.01409395973155,6.696154575406941e-26,Helicase/AAA+ Walker B motif,True,assigned_and_evaluated +795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTP/rhodanese catalytic cysteine loop,False,no_term_above_threshold +796,47717,17.947975,0.9868164,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6923828,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,7.0,19.0,100.75977788507966,8.525150430733986e-13,Helicase Ia/Ib coupling loop,True,assigned_too_few_test_positives +797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-cap and loop motifs,False,no_term_above_threshold +798,28622,15.634765,0.7207031,transposase activity,go_mf,28622,transposase activity,0.7207031,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.5873889875666075,0.0064234268580437084,0.002215330084182543,,2.8995348837209303,0.0,15.0,0.0,1.0,NOP56/58-PRP31 central coiled-coil,True,assigned_and_evaluated +799,46932,20.313751,0.9604492,Zinc finger C2H2-type,interpro,88263,Zinc-finger,0.82177734,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9956386292834891,0.8912521440823327,0.004430660168365086,0.9,201.1556089193825,18.0,18.0,108.20508166969147,1.084293130212537e-36,C2H2 ZF inter-finger disorder,True,assigned_and_evaluated +800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse helical single-residue peaks,False,no_term_above_threshold +801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic segments,False,no_term_above_threshold +802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA polymerase thumb/palm region,False,no_term_above_threshold +803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal post-domain linkers,False,no_term_above_threshold +804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic N-terminal regulatory modules,False,no_term_above_threshold +805,43583,16.396729,0.9589844,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9589844,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,14.0,14.0,416.9300699300699,6.605101239071875e-37,Disordered targeting and propeptide segments,True,assigned_and_evaluated +806,45324,20.467365,0.90625,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.90625,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.591918294849023,0.010863173158255126,0.002215330084182543,,4.903636363636364,16.0,17.0,514.8062601187264,1.0619331386023946e-42,Extracellular beta-solenoid repeats,True,assigned_and_evaluated +807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic helix-loop-strand recognition loops,False,no_term_above_threshold +808,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical bundle surface activation,False,no_term_above_threshold +809,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclic nucleotide-binding domains,False,no_term_above_threshold +810,64058,17.628353,0.9003906,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77441406,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9689510222278835,0.16340209890086588,0.006202924235711121,,26.34275265851816,0.0,15.0,0.0,1.0,Nucleotide site flanking helices,True,assigned_and_evaluated +811,36914,20.759905,0.89990234,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7607422,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,12.0,12.0,736.0617283950618,8.47146288501497e-35,Glycosyltransferase active-site loop,True,assigned_too_few_test_positives +812,36535,16.928019,0.98779297,Protein kinase domain,interpro,64148,Winged helix DNA-binding domain superfamily,0.8613281,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9843791722296394,0.37604677064681385,0.004430660168365086,0.3,84.8737561349859,7.0,11.0,57.1395125958379,1.4134523140196746e-11,Ordered core alpha-helices,True,assigned_and_evaluated +813,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-scale alpha-helical bundles,False,no_term_above_threshold +814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH18 glycan-recognition patch,False,no_term_above_threshold +815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-RT conserved motif,False,no_term_above_threshold +816,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding β–α loop-helix core,False,no_term_above_threshold +817,87326,41.392677,0.80859375,Coiled coil,keyword,87326,Coiled coil,0.80859375,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8299654836436006,0.34294688939577317,0.03943287549844927,0.29213483146067415,8.696978981643372,12.0,15.0,10.08602241488687,4.7429660028969677e-11,Coiled-coil heptad-register detector,True,assigned_and_evaluated +818,63831,18.16985,0.8803711,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8803711,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7395601954686806,0.006157100150968036,0.002658396101019052,,2.3160958401224763,0.0,16.0,0.0,1.0,Active-site recognition loops,True,assigned_and_evaluated +819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-His-Glu mid-domain hotspot,False,no_term_above_threshold +820,47529,18.473675,0.85546875,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.85546875,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9646642124051763,0.20234321848386622,0.007089056269384138,0.125,28.54304025738038,15.0,16.0,72.49635214007782,2.1623640375118794e-27,Extracellular glycosylation sequon loops,True,assigned_and_evaluated +821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal polar surface segments,False,no_term_above_threshold +822,48241,20.238758,0.95214844,RmlC-like jelly roll fold,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6904297,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,1.0,12.0,32.262445887445885,0.05084804566177454,ABC NBD coupling loop,True,assigned_too_few_test_positives +823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM interhelical loop boundary motif,False,no_term_above_threshold +824,87697,18.948503,0.90966797,Knottin,keyword,87413,Disulfide bond,0.8691406,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9889944741162054,0.4566786012430401,0.017279574656623838,0.7692307692307693,26.428810333475422,0.0,19.0,0.0,1.0,Mature extracellular bioactive regions,True,assigned_and_evaluated +825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed activation in short/fragment proteins,False,no_term_above_threshold +826,61392,16.05558,0.9243164,Leucine-rich repeat domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9147301587301587,0.027567519523278433,0.0031014621178555605,,8.888555937719918,0.0,15.0,0.0,1.0,Catalytic pocket beta-alpha loops,True,assigned_and_evaluated +827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bipartite enolase hydrophobic motif,False,no_term_above_threshold +828,48880,23.75087,0.9580078,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.9580078,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,17.0,17.0,484.7235772357723,1.7310182502290982e-45,AAT-like PLP core scaffold,True,assigned_too_few_test_positives +829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal activation in RecA-like NTPases,False,no_term_above_threshold +830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal signals and tails,False,no_term_above_threshold +831,87276,27.794424,0.62060547,Cell membrane,keyword,88161,Transmembrane helix,0.61376953,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6517966022251971,0.3209511535449242,0.11120957022596367,0.33067729083665337,2.8860030021947964,8.0,14.0,4.68884432385671,0.0001343282075018867,Juxtamembrane helix–loop boundaries,True,assigned_and_evaluated +832,49061,18.394594,0.8925781,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8925781,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8365779016855733,0.09271754870712061,0.012405848471422242,,7.4736966939989715,1.0,18.0,5.492997973097475,0.2653551106398408,Beta-propeller linker turns,True,assigned_and_evaluated +833,38317,15.862099,0.95947266,Pentatricopeptide repeat,interpro,63831,F-box-like domain superfamily,0.8881836,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9176507936507936,0.019988482970729617,0.0031014621178555605,,6.444858009276678,0.0,13.0,0.0,1.0,Proline-induced helix kinks,True,assigned_and_evaluated +834,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase DHp H+8,False,no_term_above_threshold +835,59229,23.112247,0.68847656,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.68847656,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7140730216807443,0.2582705743838511,0.0101905183872397,0.21739130434782608,25.344203755841384,18.0,18.0,106.27629233511585,1.4850343564104726e-36,SAM-MTase catalytic core segment,True,assigned_and_evaluated +836,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic beta-repeat surface loops,False,no_term_above_threshold +837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cofactor binding pocket core,False,no_term_above_threshold +838,87276,33.690212,0.65478516,Cell membrane,keyword,88161,Transmembrane helix,0.6274414,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7412751784487176,0.45183372546297096,0.11120957022596367,0.5219123505976095,4.06290326043795,12.0,16.0,6.154108175061933,2.4137614889979377e-08,Membrane glycosylation TM cores,True,assigned_and_evaluated +839,37341,20.53096,0.9819336,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9140625,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9984886231523002,0.8463852238775271,0.011962782454585734,1.0,70.7515351959844,15.0,15.0,145.4170731707317,1.2445568601222044e-32,WD40 propeller repeats and motifs,True,assigned_and_evaluated +840,87882,39.676765,0.89404297,Palmitate,keyword,87735,Lipoprotein,0.76464844,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9982230119946691,0.44179894179894186,0.002658396101019052,1.0,166.1900352733686,18.0,20.0,59.954078212290504,9.18530610399521e-31,Lipoprotein lipobox N-terminus,True,assigned_and_evaluated +841,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent helix-loop segments,False,no_term_above_threshold +842,82029,27.219303,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS transmembrane arginine motif,True,assigned_too_few_test_positives +843,64507,15.670581,0.88427734,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.88427734,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9160488335310399,0.025246395418079524,0.003987594151528578,,6.3312349398450545,0.0,12.0,0.0,1.0,D-2-hydroxyacid dehydrogenase motif,True,assigned_and_evaluated +844,35372,17.411335,0.9658203,ABC-type transporter activity,go_mf,50338,"GPCR, rhodopsin-like, 7TM",0.80810547,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,14.0,0.0,1.0,Cytosolic juxtamembrane amphipathic tails,True,assigned_too_few_test_positives +845,37341,27.235748,0.99316406,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99072266,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9977412389968444,0.7856463487312201,0.011962782454585734,1.0,65.6742151513468,12.0,20.0,87.25024390243901,3.0677153120424025e-21,Beta-propeller blade turn loops,True,assigned_and_evaluated +846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MacB periplasmic helix motifs,False,no_term_above_threshold +847,37020,16.633902,0.9760742,"Glycosyl transferase, family 1",interpro,45290,Protein kinase-like domain superfamily,0.92089844,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,14.0,0.0,1.0,Pre-HRD helix-end histidine,True,assigned_too_few_test_positives +848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CheW-like domain activation,False,no_term_above_threshold +849,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-TM interaction modules,False,no_term_above_threshold +850,52236,21.4725,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9921875,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,Alpha-solenoid repeat register,True,assigned_too_few_test_positives +851,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidohydrolase/deiminase N-terminal binding loops,False,no_term_above_threshold +852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ClpP/S49 serine proteases,False,no_term_above_threshold +853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil terminal ATPase heads,False,no_term_above_threshold +854,85672,24.450201,0.80810547,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.79589844,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8861748961929061,0.11956218982772412,0.01595037660611431,,7.495885067810371,4.0,19.0,8.424019780996113,0.00195365270195089,Internal Pro–aromatic hydrophobic motif,True,assigned_and_evaluated +855,27932,30.823402,0.80615234,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.7680664,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9322135726903009,0.5735108781860582,0.01949490474080638,0.5454545454545454,29.418501183316668,11.0,11.0,103.50868055555556,1.7269677158621563e-22,Lys/Arg-rich N-terminal tails,True,assigned_and_evaluated +856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal dependent phosphoester catalytic cores,False,no_term_above_threshold +857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Crotonase C-terminal helix,False,no_term_above_threshold +858,43583,17.594389,0.9711914,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9711914,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,17.0,18.0,393.7672882672882,3.009625101645989e-43,Chymotrypsin-like nucleophile loop,True,assigned_and_evaluated +859,72011,18.20042,0.91503906,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.8701172,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Exposed amphipathic coiled-coil helices,True,assigned_too_few_test_positives +860,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide-rich extracellular domains,False,no_term_above_threshold +861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Right-handed beta-solenoid repeats,False,no_term_above_threshold +862,85672,21.115786,0.7373047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73046875,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7549589774375907,0.060344203773852315,0.01595037660611431,,3.783246331044019,0.0,17.0,0.0,1.0,Paired HKD-adjacent helices,True,assigned_and_evaluated +863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OmpA-like lipoprotein linker,False,no_term_above_threshold +864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-junction linkers,False,no_term_above_threshold +865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,YD/RHS repeat shell activation,False,no_term_above_threshold +866,37341,29.30516,0.97216797,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.95751953,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9995847865803023,0.9801667194259784,0.011962782454585734,1.0,81.93467724979382,0.0,16.0,0.0,1.0,Beta-propeller blade-end loops,True,assigned_and_evaluated +867,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha helices,False,no_term_above_threshold +868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich surface binding loops,False,no_term_above_threshold +869,48241,22.73167,0.9838867,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9838867,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,13.0,17.0,296.0553857906799,1.249001376323727e-30,Acidic-glycine ligand-binding regions,True,assigned_too_few_test_positives +870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal accessory region,False,no_term_above_threshold +871,88161,45.73925,0.6303711,Transmembrane helix,keyword,88159,Transmembrane,0.62890625,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6681830622458554,0.45005177211859815,0.1847585290208241,0.4148681055155875,2.4358917258313575,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Transmembrane helix entry detector,True,assigned_and_evaluated +872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered proline-rich SH3-binding regions,False,no_term_above_threshold +873,45324,18.094692,0.82470703,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.82470703,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9900532859680284,0.11344517640169813,0.002215330084182543,,51.20915262772654,9.0,17.0,289.57852131678356,1.0345399949928525e-20,Extracellular repeat scaffold modules,True,assigned_and_evaluated +874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass interhelical linker loops,False,no_term_above_threshold +875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,JAMM-like HxH metal-binding motif,False,no_term_above_threshold +876,37341,17.366692,0.9609375,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.93847656,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9900514864640425,0.3651858015918531,0.011962782454585734,,30.52682793306713,0.0,19.0,0.0,1.0,Beta-strand connector loops,True,assigned_and_evaluated +877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered carrier linker arms,False,no_term_above_threshold +878,87523,19.451286,0.61816406,Glycosidase,keyword,87523,Glycosidase,0.61816406,108,keywords,Glycosidase,keyword:keywords:Glycosidase,8.0,2257.0,0.5557747887950201,0.04476812878452222,0.003544528134692069,,12.630208333333332,14.0,18.0,87.49412997903563,1.4838638963144187e-25,Secreted glycoside hydrolase surfaces,True,assigned_and_evaluated +879,87326,37.898506,0.7084961,Coiled coil,keyword,87326,Coiled coil,0.7084961,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7259370206061609,0.24308112989193953,0.03943287549844927,0.16853932584269662,6.164428204113568,17.0,20.0,10.716398815817298,4.0926532616225416e-16,Heptad-repeat coiled-coils,True,assigned_and_evaluated +880,37341,17.612425,0.9111328,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8408203,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9162680617837569,0.06482820408364093,0.011962782454585734,,5.419157652473244,0.0,17.0,0.0,1.0,Catalytic-adjacent beta-strand termini,True,assigned_and_evaluated +881,36535,20.671577,0.8930664,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8486328,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8437472185135736,0.3526387218600333,0.004430660168365086,0.7,79.59055952380952,0.0,5.0,0.0,1.0,ABC NBD Q-loop,True,assigned_and_evaluated +882,48767,23.98361,0.9550781,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9550781,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,15.0,0.0,1.0,β-sandwich/β-rich interaction surfaces,True,assigned_too_few_test_positives +883,49116,24.005785,0.88964844,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.88964844,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9994671403197157,0.8211111111111111,0.002215330084182543,1.0,370.6495555555556,20.0,20.0,87.03795620437957,8.990576307619231e-39,Karyopherin-beta HEAT-repeat solenoid,True,assigned_and_evaluated +884,83419,18.352634,0.9707031,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9423828,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,0.0,15.0,0.0,1.0,Conserved surface beta-strands,True,assigned_too_few_test_positives +885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gram-negative beta-barrel extracellular loops,False,no_term_above_threshold +886,85672,16.816097,0.7236328,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.71240234,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8086009805392966,0.09640531110988573,0.01595037660611431,,6.044077421528114,1.0,18.0,2.223005219985086,0.5707478730186062,Helix/strand capping segments,True,assigned_and_evaluated +887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic TM-helix junctions,False,no_term_above_threshold +888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-coiled helical regulatory scaffolds,False,no_term_above_threshold +889,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed loop connectors,False,no_term_above_threshold +890,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Pro-rich coupling linkers,False,no_term_above_threshold +891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal secretin S-domain linkers,False,no_term_above_threshold +892,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thiamine diphosphate-binding core,False,no_term_above_threshold +893,88263,44.628925,0.9604492,Zinc-finger,keyword,29166,zinc ion binding,0.92089844,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9753992260736865,0.216529679938502,0.014621178555604785,,14.809317806703001,3.0,20.0,3.9087194055944052,0.06539436951734971,Zinc-ligand flanking residues,True,assigned_and_evaluated +894,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr/Pro-rich IDRs,False,no_term_above_threshold +895,6678,20.06467,0.74560547,phosphorelay signal transduction system,go_bp,6678,phosphorelay signal transduction system,0.74560547,32,go,GO:0000160,go_bp:go:GO:0000160,,,,,,,,6.0,16.0,154.19224137931033,3.2033926331062893e-12,Subfamily-specific polyanion-binding surfaces,True,assigned_too_few_test_positives +896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-kinase leucine-rich helix,False,no_term_above_threshold +897,88058,31.160357,0.6928711,Signal,keyword,88058,Signal,0.6928711,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7028811425163193,0.13377222733505048,0.09127159946832078,,1.4656500829864512,4.0,20.0,1.4409909365558913,0.4670478563492871,Small-residue-rich peptide IDRs,True,assigned_and_evaluated +898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1-TM2 hairpin packing,False,no_term_above_threshold +899,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature C-terminal functional cores,False,no_term_above_threshold +900,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan assembly transmembrane helix cores,False,no_term_above_threshold +901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible low-complexity linkers,False,no_term_above_threshold +902,52236,21.848381,0.9741211,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8364258,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR LxPx turn motif,True,assigned_too_few_test_positives +903,59224,16.28258,0.64697266,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.64697266,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7016507936507936,0.026664038959120923,0.0031014621178555605,,8.597247990105132,1.0,15.0,9.158371735791091,0.16775931673620395,"Esterase/lipase cores, C-terminal bias",True,assigned_and_evaluated +904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase palm helix-loop motif,False,no_term_above_threshold +905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Ser/Thr-rich IDRs,False,no_term_above_threshold +906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gingivalis fimbrial C-terminal β-strand motif,False,no_term_above_threshold +907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic basic nucleic acid interfaces,False,no_term_above_threshold +908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal and transmembrane activation,False,no_term_above_threshold +909,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA/RNA-binding domain edge–IDR interface,False,no_term_above_threshold +910,86130,24.054562,0.9296875,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.92626953,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9917460317460317,0.17794711588036363,0.0031014621178555605,,57.3752343631401,0.0,14.0,0.0,1.0,GyrA β-pinwheel DNA-binding hotspot,True,assigned_and_evaluated +911,46082,20.8235,0.9741211,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9741211,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9998095238095238,0.9379251700680272,0.0031014621178555605,1.0,302.41387269193393,10.0,16.0,94.3370253164557,2.799281029738777e-18,PH/RA membrane-targeting module,True,assigned_and_evaluated +912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered terminal anchor segments,False,no_term_above_threshold +913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA polymerase alpha assembly module,False,no_term_above_threshold +914,85388,49.125546,0.97753906,Glutaredoxin,gene3d,85388,Glutaredoxin,0.97753906,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.9984437527790129,0.7329326923076923,0.003544528134692069,0.875,206.7786358173077,11.0,11.0,216.80363636363634,5.165684909670471e-26,Post-CXXC helix–turn–β segment,True,assigned_and_evaluated +915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad cis-IPPS domain activation,False,no_term_above_threshold +916,52236,28.044018,0.99560547,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.97509766,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR/Sel1 hydrophobic binding groove,True,assigned_too_few_test_positives +917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity activation regions,False,no_term_above_threshold +918,37020,15.901751,0.99853516,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.95703125,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,19.0,19.0,816.7260273972603,1.642370697279621e-54,Acidic beta-alpha donor loop,True,assigned_too_few_test_positives +919,81289,24.420067,0.99853516,lambda repressor-like DNA-binding domains,gene3d,87384,DNA-binding,0.60498047,61,gene3d,1.10.260.40,gene3d:gene3d:1.10.260.40,,,,,,,,16.0,16.0,458.6230769230769,1.243423145389655e-42,C-terminal helix-to-coil hinge,True,assigned_too_few_test_positives +920,88164,16.06714,0.7182617,Transposition,keyword,88164,Transposition,0.7182617,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.5870337477797513,0.0064234268580437084,0.002215330084182543,,2.8995348837209303,2.0,13.0,111.85928705440901,0.00026194971325511673,Mobile-element and genome-maintenance domains,True,assigned_and_evaluated +921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal targeting sequences,False,no_term_above_threshold +922,25169,18.837032,0.80371094,pilus,go_cc,25169,pilus,0.80371094,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.691918294849023,0.03284434956566104,0.002215330084182543,,14.825939393939395,0.0,16.0,0.0,1.0,Surface low-complexity repeats,True,assigned_and_evaluated +923,85656,16.551178,0.66796875,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.66796875,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.6347619047619047,0.2879296157984682,0.0031014621178555605,0.2857142857142857,92.83673469387753,11.0,13.0,119.54629967189209,4.151665225051338e-22,Ligand-binding pocket scaffold,True,assigned_and_evaluated +924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline cysteine low complexity repeats,False,no_term_above_threshold +925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHMP kinase ATP-binding N-lobe,False,no_term_above_threshold +926,36886,16.268904,0.69140625,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.69140625,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.6186638506002669,0.018093178709714705,0.003544528134692069,,5.104538043478262,0.0,12.0,0.0,1.0,Class I aaRS anticodon-binding domain,True,assigned_and_evaluated +927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged flexible interdomain linkers,False,no_term_above_threshold +928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved N-terminal ThDP substrate-binding motif,False,no_term_above_threshold +929,35372,16.51922,0.9746094,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9746094,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,13.0,17.0,536.3826989619376,4.389817575033606e-34,Hydrophobic transmembrane helices,True,assigned_too_few_test_positives +930,59224,26.719593,0.98291016,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.98291016,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9994920634920635,0.8809523809523809,0.0031014621178555605,1.0,284.0442176870748,20.0,20.0,137.37557603686636,1.3818410501239142e-42,ABH strand-loop active-site motif,True,assigned_and_evaluated +931,81858,16.752306,0.9614258,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.66552734,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane alpha-helix interfaces,True,assigned_too_few_test_positives +932,30398,19.270117,0.65185547,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.65185547,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6337731725087022,0.2762718008619648,0.004873726185201595,0.2727272727272727,56.685950413223146,13.0,14.0,66.86275017253278,2.5735117388307496e-23,ABC ATPase NBD linkers,True,assigned_and_evaluated +933,36409,22.944735,0.9916992,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.9916992,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,15.0,0.0,1.0,Disordered low-complexity linkers,True,assigned_too_few_test_positives +934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SprT metalloprotease dual-motif detector,False,no_term_above_threshold +935,88161,55.33155,0.6621094,Transmembrane helix,keyword,88161,Transmembrane helix,0.6621094,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6817569857157751,0.4707042088537998,0.1847585290208241,0.42685851318944845,2.5476724205827965,15.0,15.0,5.4274920345926265,2.044231257442523e-11,Transmembrane helix N-cap recognition,True,assigned_and_evaluated +936,59224,28.82552,0.9707031,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9707031,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Hydrolase post-catalytic alpha-helix,True,assigned_and_evaluated +937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal accessory domains,False,no_term_above_threshold +938,84753,15.838088,0.7832031,3.30.420.40,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7373047,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,0.0,16.0,0.0,1.0,MDR structural Zn-Cys helix motif,True,assigned_too_few_test_positives +939,25169,17.129677,0.7792969,pilus,go_cc,25169,pilus,0.7792969,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8845026642984015,0.05674606018747774,0.002215330084182543,,25.615171568627456,0.0,19.0,0.0,1.0,Extracellular beta-sandwich glycan-binding modules,True,assigned_and_evaluated +940,37894,24.760727,1.0,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8652344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR Rossmann-fold core segment,True,assigned_too_few_test_positives +941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad activation with mid-protein peaks,False,no_term_above_threshold +942,63831,19.011835,0.8984375,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8984375,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.611135791500074,0.004940609064490804,0.002658396101019052,,1.858492443092624,0.0,15.0,0.0,1.0,LMW-PTP post-catalytic helix motif,True,assigned_and_evaluated +943,38317,18.482847,0.70410156,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.70410156,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.5678095238095239,0.023066559366325172,0.0031014621178555605,,7.4373177842565585,0.0,17.0,0.0,1.0,RbsA-family ABC ATPase NBD1,True,assigned_and_evaluated +944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-rich low-complexity repeats,False,no_term_above_threshold +945,25169,15.846361,0.73876953,pilus,go_cc,25169,pilus,0.73876953,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8858348134991119,0.14591334163171726,0.002215330084182543,0.2,65.86528241255718,0.0,15.0,0.0,1.0,Phage distal tail beta-strands,True,assigned_and_evaluated +946,35372,17.751276,0.83251953,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.83251953,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,15.0,0.0,1.0,Cytosolic TM boundary regions,True,assigned_too_few_test_positives +947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble N-terminal pre-TM regions,False,no_term_above_threshold +948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory nucleotide-sugar glycosyltransferases,False,no_term_above_threshold +949,87326,40.341057,0.74560547,Coiled coil,keyword,87326,Coiled coil,0.74560547,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7693545545006012,0.3442651954269039,0.03943287549844927,0.3595505617977528,8.730410630095754,18.0,18.0,12.607528018608585,3.905291109887263e-20,Heptad-periodic coiled-coil register,True,assigned_and_evaluated +950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PNMA/Gag amphipathic helix motif,False,no_term_above_threshold +951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand N-cap recognition,False,no_term_above_threshold +952,55053,18.685678,0.9682617,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9682617,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,19.0,0.0,1.0,Short charged binding segments,True,assigned_too_few_test_positives +953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cationic amphipathic segments,False,no_term_above_threshold +954,49236,16.910223,0.7861328,C-type lectin fold,interpro,49236,C-type lectin fold,0.7861328,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.5938721136767318,0.026772264067346035,0.002215330084182543,,12.085,0.0,17.0,0.0,1.0,GW/YW peptidoglycan-binding surface,True,assigned_and_evaluated +955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal polyanion-binding interfaces,False,no_term_above_threshold +956,37071,16.667135,0.8720703,Homeodomain,interpro,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.7373047,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,2.0,17.0,24.270710360268673,0.00525024086666359,TF activation IDRs upstream DBD,True,assigned_too_few_test_positives +957,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane domains of transporters,False,no_term_above_threshold +958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge helix-start/loop-turn motif,False,no_term_above_threshold +959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RTX Ca2+-repeat linker motif,False,no_term_above_threshold +960,81858,17.660786,0.97021484,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.72998047,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,8.0,14.0,149.42606516290726,2.851605007346443e-16,TM6-biased GPCR transmembrane helices,True,assigned_too_few_test_positives +961,37020,17.780252,0.99316406,"Glycosyl transferase, family 1",interpro,64058,NAD(P)-binding domain superfamily,0.79296875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,10.0,0.0,1.0,SDR beta-to-alpha junction motif,True,assigned_too_few_test_positives +962,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-trefoil β-strand cores,False,no_term_above_threshold +963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal hydrophobic/aromatic module,False,no_term_above_threshold +964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrolase region,False,no_term_above_threshold +965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking hinge loops,False,no_term_above_threshold +966,85656,16.876177,0.8823242,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73291016,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8888571428571428,0.014832467677029847,0.0031014621178555605,,4.782411363865195,0.0,16.0,0.0,1.0,REC beta-strand core preference,True,assigned_and_evaluated +967,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helices and aromatic hotspots,False,no_term_above_threshold +968,47717,18.707771,0.9223633,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9223633,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,12.0,13.0,252.4530698659139,1.884882707865338e-28,Hel1-Hel2 linker helix,True,assigned_too_few_test_positives +969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD-binding loop scaffold,False,no_term_above_threshold +970,-1,,,,,-1,,,0,,,,,,,,,,,,,,,dDENN-focused DENN GEF feature,False,no_term_above_threshold +971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved aromatic helical motifs,False,no_term_above_threshold +972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Gly-rich IDRs,False,no_term_above_threshold +973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor-effector linker helices,False,no_term_above_threshold +974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding scaffold patches,False,no_term_above_threshold +975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site anion/metal helix,False,no_term_above_threshold +976,52236,19.986774,0.99902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9946289,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,19.0,20.0,212.13464419475653,3.684411585858698e-43,TPR helix B register detector,True,assigned_too_few_test_positives +977,88114,16.400564,0.7783203,TPR repeat,keyword,46079,Tetratricopeptide-like helical domain superfamily,0.70947266,83,keywords,TPR repeat,keyword:keywords:TPR repeat,,,,,,,,12.0,18.0,124.59979101358411,2.3079490123591758e-23,TPR helix hydrophobic core,True,assigned_too_few_test_positives +978,64507,32.961205,0.99560547,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99560547,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9991103202846976,0.8264602137151158,0.003987594151528578,1.0,207.25785581722405,19.0,19.0,165.15512465373962,5.007107605336941e-42,Ankyrin-flanking effector appendages,True,assigned_and_evaluated +979,87697,16.617735,0.8383789,Knottin,keyword,87413,Disulfide bond,0.7578125,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8758410210168551,0.06281389998924441,0.017279574656623838,,3.6351531352749906,0.0,13.0,0.0,1.0,Conserved sheet-edge binding hotspots,True,assigned_and_evaluated +980,82029,19.996767,0.97558594,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8203125,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,4.0,19.0,39.595550390171006,5.4065778119213196e-06,Lipid-exposed transmembrane helical faces,True,assigned_too_few_test_positives +981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged interaction motifs,False,no_term_above_threshold +983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SEA-domain glycoprotein ectodomains,False,no_term_above_threshold +984,45289,19.429468,0.9995117,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.9995117,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,17.0,17.0,903.3484848484848,6.1436820159935675e-50,Aromatic/His gating helix,True,assigned_too_few_test_positives +985,88160,15.812285,0.84228516,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7138672,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,12.0,14.0,248.07628294036058,6.4187040391343665e-28,Outer-membrane beta-barrel loops,True,assigned_too_few_test_positives +986,52236,23.911377,0.99853516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9941406,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR B-helix register residues,True,assigned_too_few_test_positives +987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidase signature motif hotspots,False,no_term_above_threshold +988,37894,15.992919,0.9975586,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.97753906,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,6.0,18.0,236.59126984126982,2.67940655858575e-13,Gly-rich Rossmann NAD(P) β1–α1 loop,True,assigned_too_few_test_positives +989,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended non-globular interaction scaffolds,False,no_term_above_threshold +990,87857,16.14147,0.60839844,Nucleus,keyword,88150,Transcription regulation,0.60253906,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6484283875638498,0.13648629813807808,0.06247230837394772,0.028368794326241134,2.184748758139307,15.0,15.0,6.059044715447154,3.970157888665949e-12,N-terminal low-complexity IDRs,True,assigned_and_evaluated +991,84753,24.10704,0.7836914,3.30.420.40,gene3d,84753,3.30.420.40,0.7836914,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,14.0,14.0,414.03472222222223,7.243044084900326e-37,Hsp70 SBDβ hydrophobic strand,True,assigned_too_few_test_positives +992,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane interface helix/loop caps,False,no_term_above_threshold +993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface helices and flexible tails,False,no_term_above_threshold +994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro/Thr-rich disordered linkers,False,no_term_above_threshold +995,81858,17.376486,0.98779297,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.62402344,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,20.0,20.0,261.4956140350877,8.413399189284548e-48,Class A GPCR helix-loop junctions,True,assigned_too_few_test_positives +996,37097,23.429884,0.96728516,Cro/C1-type helix-turn-helix domain,interpro,87566,Homeobox,0.8203125,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,12.0,16.0,421.84669811320754,3.62405245586592e-30,Regulatory tails flanking DBDs,True,assigned_too_few_test_positives +997,36535,20.687914,0.95166016,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9511719,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9493324432576769,0.8904430660168364,0.004430660168365086,0.9,200.97299999999998,17.0,17.0,89.79066265060241,2.357720211227094e-33,Kinase C-terminal cap region,True,assigned_and_evaluated +998,49116,25.175413,0.9667969,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9667969,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.997158081705151,0.31606060606060604,0.002215330084182543,,142.6697575757576,18.0,18.0,87.03795620437957,5.040547535858956e-35,Solenoid helix C-cap detector,True,assigned_and_evaluated +999,38873,20.448088,0.984375,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9121094,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9987566607460036,0.7560606060606061,0.002215330084182543,0.6,341.2857575757576,13.0,13.0,171.32471264367817,2.6588953672088044e-29,ABC NBD pre-P-loop flank,True,assigned_and_evaluated +1000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal trafficking signals and linkers,False,no_term_above_threshold +1001,59229,39.698875,0.89697266,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.89697266,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.909209450780429,0.7118554584536356,0.0101905183872397,0.6956521739130435,69.8546856404285,9.0,14.0,68.32047364400306,2.449092247190432e-15,Rossmann-like SAM-transferase fold,True,assigned_and_evaluated +1002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gag-Pol protease-integrase marker,False,no_term_above_threshold +1003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLiM-rich cytosolic C-termini,False,no_term_above_threshold +1004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical anchor modules,False,no_term_above_threshold +1005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged juxtadomain helical interfaces,False,no_term_above_threshold +1006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LysM/CBM14 glycan-binding modules,False,no_term_above_threshold +1007,87326,41.452988,0.8105469,Coiled coil,keyword,87326,Coiled coil,0.8105469,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8239717649985489,0.36629325341409863,0.03943287549844927,0.3258426966292135,9.289032280400232,16.0,19.0,10.616865699880913,4.307920495700391e-15,Coiled-coil heptad register,True,assigned_and_evaluated +1008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal membrane-interaction segments,False,no_term_above_threshold +1009,82029,21.585388,0.9926758,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7529297,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,Cytosolic helix-capping loops,True,assigned_too_few_test_positives +1010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-domain non-catalytic activation,False,no_term_above_threshold +1011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trafficking IDR repeat appendages,False,no_term_above_threshold +1012,36091,23.22981,1.0,GNAT domain,interpro,85712,3.40.630.30,0.9824219,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,19.0,0.0,1.0,Histidine kinase ATP-lid loop,True,assigned_too_few_test_positives +1013,63960,18.3351,0.9345703,FAD/NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.84375,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,8.0,0.0,1.0,ABC transporter NBD motifs,True,assigned_too_few_test_positives +1014,87489,22.879292,0.8520508,GPI-anchor,keyword,87522,Glycoprotein,0.6015625,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9155555555555556,0.2511498578102157,0.0031014621178555605,0.42857142857142855,80.97788986823669,6.0,19.0,46.488109161793375,4.868635684831556e-09,Signal peptide and post-cleavage N-terminus,True,assigned_and_evaluated +1015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal amphipathic alpha-helix,False,no_term_above_threshold +1016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed interaction/gating patches,False,no_term_above_threshold +1017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site–adjacent pocket-lining elements,False,no_term_above_threshold +1018,49061,16.219799,0.8598633,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8598633,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8638643209639172,0.04153271810038413,0.012405848471422242,,3.347833741163106,0.0,18.0,0.0,1.0,Acidic sheet-edge caps,True,assigned_and_evaluated +1019,36668,15.813832,0.89208984,AMP-dependent synthetase/ligase domain,interpro,36668,AMP-dependent synthetase/ligase domain,0.89208984,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,16.0,0.0,1.0,Extracellular WSC sensor activation,True,assigned_too_few_test_positives +1020,59229,41.417328,0.98779297,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98779297,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.888968899614651,0.7610631515094033,0.0101905183872397,0.782608695652174,74.68345795464013,16.0,16.0,106.27629233511585,1.339381655082284e-32,SAM-pocket helix-loop lid,True,assigned_and_evaluated +1021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA 3'-end positioning subdomains,False,no_term_above_threshold +1022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs and coiled-coils,False,no_term_above_threshold +1023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-rich binding cores,False,no_term_above_threshold +1024,47128,15.795002,0.8457031,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.8457031,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,0.0,18.0,0.0,1.0,Non-globular low-complexity regions,True,assigned_too_few_test_positives +1025,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-active-site scaffold,False,no_term_above_threshold +1026,87326,35.998295,0.72216797,Coiled coil,keyword,87326,Coiled coil,0.72216797,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7301479124341806,0.32567447799968063,0.03943287549844927,0.33707865168539325,8.258958391519991,18.0,18.0,12.607528018608585,3.905291109887263e-20,Heptad-specific coiled-coil detector,True,assigned_and_evaluated +1027,36535,19.45424,0.98046875,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9760742,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9980418335558522,0.8981196581196581,0.004430660168365086,0.9,202.70560683760684,17.0,17.0,89.79066265060241,2.357720211227094e-33,Kinase C-lobe terminal segment,True,assigned_and_evaluated +1028,30856,15.817059,0.78271484,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.6035156,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.8239786856127886,0.010787885363612804,0.002215330084182543,,4.86965145313482,2.0,18.0,14.886641697877652,0.013432062032986268,Transmembrane helix–coil transitions,True,assigned_and_evaluated +1029,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fe2OG dioxygenase catalytic core,False,no_term_above_threshold +1030,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic rhodanese-like region,False,no_term_above_threshold +1031,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIR-cGAS-STING defense modules,False,no_term_above_threshold +1032,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-face loops and helices,False,no_term_above_threshold +1033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich disordered linkers,False,no_term_above_threshold +1034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cellulosomal dockerin-linker signature,False,no_term_above_threshold +1035,52941,17.702736,0.92822266,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.6123047,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,11.0,0.0,1.0,Transporter transmembrane helices,True,assigned_too_few_test_positives +1036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal HECT-biased catalytic cores,False,no_term_above_threshold +1037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +1038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid/LPS translocation interfaces,False,no_term_above_threshold +1039,50338,16.187206,0.96484375,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.62158203,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,13.0,0.0,1.0,Kinked transporter transmembrane helices,True,assigned_too_few_test_positives +1040,69819,29.279757,0.9121094,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8984375,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,14.0,15.0,391.875117370892,8.006690669254916e-36,Kinase N-terminal phosphate-binding subdomain,True,assigned_too_few_test_positives +1041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane-adjacent hydrophobic aromatic loops,False,no_term_above_threshold +1042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase N-termini and TGase beta-strands,False,no_term_above_threshold +1043,85364,16.891132,0.6972656,Periplasmic binding protein-like II,gene3d,64148,Winged helix DNA-binding domain superfamily,0.64697266,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,19.0,190.1786283891547,1.9468739952274682e-25,Bacterial HTH effector-binding core,True,assigned_too_few_test_positives +1044,37446,20.182325,0.9873047,F-box domain,interpro,43624,Homedomain-like superfamily,0.87939453,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9944444444444445,0.24029195011337867,0.0031014621178555605,,77.47699020084224,0.0,15.0,0.0,1.0,HTH-like helix-start/loop signal,True,assigned_and_evaluated +1045,31094,15.615596,0.9741211,phosphopantetheine binding,go_mf,31094,phosphopantetheine binding,0.9741211,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9967512238540276,0.45820652385869776,0.004430660168365086,0.8,103.4172124349081,1.0,17.0,41.75140056022409,0.039689626711981424,Acyl-chain pocket β-strand,True,assigned_and_evaluated +1046,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core transmembrane transport helices,False,no_term_above_threshold +1047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic coiled-coil scaffolding tails,False,no_term_above_threshold +1048,59211,17.880228,0.9892578,Nucleotide-diphospho-sugar transferases,interpro,59224,Alpha/Beta hydrolase fold,0.8671875,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9987813620071685,0.8796319732161249,0.011076650420912717,1.0,79.41317454195175,18.0,18.0,244.34836065573774,7.288942336525665e-43,Donor-edge beta-strand motif,True,assigned_and_evaluated +1049,87697,23.550695,0.9086914,Knottin,keyword,87697,Knottin,0.9086914,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9497005849575731,0.1467732371062895,0.017279574656623838,,8.494030670484497,0.0,13.0,0.0,1.0,Conserved flavoprotein beta-strand motif,True,assigned_and_evaluated +1050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protein complex interface scaffolds,False,no_term_above_threshold +1051,64620,15.590666,0.95654297,Histidine kinase/HSP90-like ATPase superfamily,interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8378906,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,ELTP motif after catalytic His,True,assigned_too_few_test_positives +1052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site capping loops,False,no_term_above_threshold +1053,37341,27.872738,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98876953,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 propeller loop turns,True,assigned_and_evaluated +1054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane interhelical loop activation,False,no_term_above_threshold +1055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta barrel gating loop,False,no_term_above_threshold +1056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered low-complexity tails,False,no_term_above_threshold +1057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β–α–β ligand-binding loop,False,no_term_above_threshold +1058,85664,20.486395,0.97998047,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.97998047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase glycine-rich donor loop,True,assigned_too_few_test_positives +1059,63960,18.096704,0.91552734,FAD/NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8847656,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,11.0,0.0,1.0,SDR cofactor-binding helix,True,assigned_too_few_test_positives +1060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain helical scaffold residues,False,no_term_above_threshold +1061,87276,37.258236,0.6870117,Cell membrane,keyword,88161,Transmembrane helix,0.67871094,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7517527099974975,0.518163853323283,0.11120957022596367,0.545816733067729,4.659345884265536,10.0,16.0,5.128423479218277,5.4065778119213196e-06,Pore-lining transmembrane gating helices,True,assigned_and_evaluated +1062,85649,25.665564,0.69628906,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6958008,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.648047954536608,0.2554168154667086,0.0101905183872397,0.21739130434782608,25.064163152537443,16.0,16.0,110.61410018552876,7.117153535323136e-33,Nucleic acid SAM MTases,True,assigned_and_evaluated +1063,64058,19.612762,0.7910156,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.79052734,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9098146614865296,0.28942745240323686,0.006202924235711121,0.07142857142857142,46.659840005293255,5.0,16.0,35.62440248565965,4.0223886347024287e-07,Acidic low-complexity patches,True,assigned_and_evaluated +1064,36010,17.988003,0.9980469,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.90771484,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,17.0,17.0,509.58119658119665,7.41832896353285e-46,AB hydrolase N-terminal activation,True,assigned_too_few_test_positives +1065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding cores,False,no_term_above_threshold +1066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UBC/UEV HPN-loop interface,False,no_term_above_threshold +1067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP carboxylate-amine ligase core,False,no_term_above_threshold +1068,83302,16.805439,0.95654297,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9536133,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9705739496478589,0.22946664112839485,0.004873726185201595,,47.08238263879884,6.0,17.0,72.56105476673429,3.1141255949355763e-10,Ala-centered OB-fold β-strand,True,assigned_and_evaluated +1069,87274,19.419098,0.7104492,Cell inner membrane,keyword,88161,Transmembrane helix,0.7011719,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.8738028776325344,0.6456048291506166,0.0358883473637572,0.7037037037037037,17.98926048633261,9.0,15.0,23.396075866579462,4.368525593095685e-11,Pre-TM cytosolic amphipathic caps,True,assigned_and_evaluated +1070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed amphipathic alpha helices,False,no_term_above_threshold +1071,47529,22.126696,0.87646484,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.87646484,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9468150379294958,0.29326444390862866,0.007089056269384138,0.4375,41.36861561886093,3.0,16.0,14.499270428015565,0.0018658908624807312,Ser/Thr beta-sandwich loop motif,True,assigned_and_evaluated +1072,87149,24.244303,0.76660156,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.76660156,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8505816189194386,0.1951852910290814,0.012405848471422242,,15.733328637594168,0.0,16.0,0.0,1.0,Acidic ALPS-like membrane binders,True,assigned_and_evaluated +1073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAL/GGDEF c-di-GMP signaling,False,no_term_above_threshold +1074,88160,16.210918,0.84228516,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7006836,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Outer membrane beta-barrel loops,True,assigned_too_few_test_positives +1075,81858,19.644367,0.97216797,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.97216797,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,15.0,15.0,261.4956140350877,1.9644988468651927e-36,GPCR intracellular signaling interfaces,True,assigned_too_few_test_positives +1076,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal peptides/anchors,False,no_term_above_threshold +1077,83267,18.40566,0.82714844,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.82714844,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,13.0,0.0,1.0,PMI N-terminal activation hotspot,True,assigned_too_few_test_positives +1078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GOLPH3/Vps74 C-terminal PI4P hotspot,False,no_term_above_threshold +1079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATPase and TOPRIM active sites,False,no_term_above_threshold +1080,87697,17.351326,0.6855469,Knottin,keyword,87697,Knottin,0.6855469,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.6787184111350026,0.05879536671021271,0.017279574656623838,,3.4025934016653867,0.0,19.0,0.0,1.0,Endosomal FYVE and Rab effectors,True,assigned_and_evaluated +1081,85649,29.476452,0.97509766,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96777344,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.883091354949204,0.7056625350531265,0.0101905183872397,0.782608695652174,69.24697137456114,16.0,16.0,110.61410018552876,7.117153535323136e-33,Glycine-rich SAM-binding submotifs,True,assigned_and_evaluated +1082,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenol-linked glycosylation TM signature,False,no_term_above_threshold +1083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal Ser/Pro-rich low-complexity IDRs,False,no_term_above_threshold +1084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Papain-like acidic loop motif,False,no_term_above_threshold +1085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flagellar axial helix detector,False,no_term_above_threshold +1086,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LTR retrotransposon integrase catalytic domain,False,no_term_above_threshold +1087,36104,17.901728,0.9555664,Rho GTPase-activating protein domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.91748047,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,11.0,0.0,1.0,Kinase C-lobe regulatory segment,True,assigned_too_few_test_positives +1088,64058,18.611229,0.6459961,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.640625,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6056939048468251,0.1905880118994873,0.006202924235711121,0.21428571428571427,30.72551020408163,11.0,13.0,96.45992057655536,4.3739405387455496e-21,Mid-sequence substrate gating loop,True,assigned_and_evaluated +1089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader docking helix,False,no_term_above_threshold +1090,38890,20.722443,0.99658203,HNH nuclease,interpro,46933,"Zinc finger, NHR/GATA-type",0.97314453,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,12.0,19.0,818.5949656750572,2.1671951925829672e-33,Basic low-complexity binding patches,True,assigned_too_few_test_positives +1091,87489,17.108599,0.7792969,GPI-anchor,keyword,88161,Transmembrane helix,0.64501953,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8137777777777778,0.02064038254744445,0.0031014621178555605,,6.6550490585117315,0.0,17.0,0.0,1.0,Lumenal aromatic-acidic juxtamembrane motif,True,assigned_and_evaluated +1092,52940,15.809819,0.9082031,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.84814453,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,18.0,0.0,1.0,Short low-complexity connector loops,True,assigned_too_few_test_positives +1093,85664,16.711178,0.9614258,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.93359375,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,17.0,0.0,1.0,ANL AMP-binding pocket helices,True,assigned_too_few_test_positives +1094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FtsH M41 metalloprotease domain,False,no_term_above_threshold +1095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended intrinsically disordered linkers,False,no_term_above_threshold +1096,87882,18.520424,0.7988281,Palmitate,keyword,88058,Signal,0.7338867,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9622760254701614,0.07436867278787654,0.002658396101019052,,27.975015747039556,2.0,18.0,7.401738050900062,0.048953421764876846,N-terminal secretory signal peptide,True,assigned_and_evaluated +1097,38317,15.820767,0.8178711,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8178711,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6672063492063492,0.017039803766308446,0.0031014621178555605,,5.4941195857940235,0.0,16.0,0.0,1.0,Gly/Pro-rich mid-protein loops,True,assigned_and_evaluated +1098,64003,30.544697,0.99902344,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.9863281,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,16.0,16.0,130.4617067833698,5.252801912935239e-34,C2H2 helix-end histidine,True,assigned_and_evaluated +1099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic membrane-facing acidic IDRs,False,no_term_above_threshold +1100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helix bundles,False,no_term_above_threshold +1101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-coiled-coil acidic stretch,False,no_term_above_threshold +1102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic metal binding scaffolds,False,no_term_above_threshold +1103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane β-barrel signature,False,no_term_above_threshold +1104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix and tail signature,False,no_term_above_threshold +1105,31094,17.060102,0.9267578,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.78515625,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9437249666221628,0.21824923924279988,0.004430660168365086,,49.25885329709993,0.0,15.0,0.0,1.0,AsnB adenylation domain detector,True,assigned_and_evaluated +1106,88009,28.191935,0.69921875,Repeat,keyword,88009,Repeat,0.69921875,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7357611900294828,0.221102297296627,0.07266282676118742,0.09146341463414634,3.0428529573078484,10.0,19.0,4.666092741146547,2.1653172507778262e-05,Acidic low-complexity disordered repeats,True,assigned_and_evaluated +1107,87697,18.84034,0.86865234,Knottin,keyword,87697,Knottin,0.86865234,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9889077709185915,0.42954628091132885,0.017279574656623838,0.8205128205128205,24.8586142568428,0.0,20.0,0.0,1.0,Non-catalytic effector/regulatory regions,True,assigned_and_evaluated +1108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic interaction helices,False,no_term_above_threshold +1109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short basic-aromatic interface helix,False,no_term_above_threshold +1110,87413,51.268944,0.90478516,Disulfide bond,keyword,87413,Disulfide bond,0.90478516,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9402972980936385,0.5645810508198376,0.0717766947275144,0.845679012345679,7.865798961113416,16.0,19.0,9.95976153436557,1.1702305999732164e-14,Disulfide-rich secreted cores,True,assigned_and_evaluated +1111,87276,33.01092,0.6323242,Cell membrane,keyword,88161,Transmembrane helix,0.6113281,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7834981112439574,0.5922115780027597,0.11120957022596367,0.5976095617529881,5.325185384670234,2.0,11.0,1.491905012136226,0.6159853475406871,YIP1/YIF1 loop-TM motif,True,assigned_and_evaluated +1112,35372,18.286951,0.8696289,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.8696289,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,1.0,18.0,38.96797385620915,0.042428550836966346,Cytoplasmic juxtamembrane polar motif,True,assigned_too_few_test_positives +1113,37341,20.059774,0.64453125,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.63720703,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.8681780435143663,0.5516971680020031,0.011962782454585734,0.7407407407407407,46.117796599278556,5.0,18.0,40.393631436314365,2.3447063282943533e-07,"Ycf48 beta-strands, LanC helices",True,assigned_and_evaluated +1114,46277,16.443779,0.67333984,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.67333984,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.6307779486764349,0.12792015251031644,0.004873726185201595,0.09090909090909091,26.246889474162202,7.0,13.0,101.27323465178354,4.194447517743558e-13,Two metal acidic nuclease cores,True,assigned_and_evaluated +1115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amino acid kinase hydrophobic motif,False,no_term_above_threshold +1116,37894,17.440014,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8510742,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,9.0,709.7738095238095,4.424699527134814e-26,SDR pre-catalytic SS motif,True,assigned_too_few_test_positives +1117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA polymerase right-hand core,False,no_term_above_threshold +1118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-rich polyanion-binding effectors,False,no_term_above_threshold +1119,88160,18.741734,0.84521484,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6904297,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,18.0,18.0,289.42233009708735,4.0738218914291243e-44,Outer-membrane β-barrel initiation motifs,True,assigned_too_few_test_positives +1120,66234,16.488243,0.9267578,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.9267578,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,7.0,18.0,92.00771604938271,1.4955846853639226e-12,Cysteine hydrolase catalytic motif,True,assigned_too_few_test_positives +1121,49116,23.578259,0.97021484,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97021484,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.999911190053286,0.9666666666666666,0.002215330084182543,1.0,436.3533333333333,18.0,20.0,78.33416058394161,8.069857698062721e-33,Helix-capping coil linkers,True,assigned_and_evaluated +1122,87108,20.408037,0.94970703,ANK repeat,keyword,82597,Tetratricopeptide repeat domain,0.9038086,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.974298141557928,0.0796516233193588,0.003987594151528578,,19.974857092421423,0.0,18.0,0.0,1.0,HetP IxAIxGxY motif,True,assigned_and_evaluated +1123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early N-terminal interface segments,False,no_term_above_threshold +1124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich anion-binding loop,False,no_term_above_threshold +1125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metallohydrolase catalytic cores,False,no_term_above_threshold +1126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity activation patches,False,no_term_above_threshold +1127,37894,17.661467,1.0,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.93359375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,Glycine-rich NAD(P)H-binding loop,True,assigned_too_few_test_positives +1128,87326,26.934404,0.66259766,Coiled coil,keyword,87326,Coiled coil,0.66259766,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6739914590157138,0.23799388449886313,0.03943287549844927,0.24719101123595505,6.035417947347574,16.0,17.0,11.865908723396316,9.12494090100373e-17,C-terminal interaction scaffolds,True,assigned_and_evaluated +1129,59229,30.719389,0.984375,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.984375,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8615079210618505,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,18.0,18.0,106.27629233511585,1.4850343564104726e-36,SAM-binding glycine-rich loop,True,assigned_and_evaluated +1130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil stalks,False,no_term_above_threshold +1131,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine-rich disordered linkers,False,no_term_above_threshold +1132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2/PH beta-sandwich cores,False,no_term_above_threshold +1133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical interaction region,False,no_term_above_threshold +1134,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha junction micro-motif,False,no_term_above_threshold +1135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Homopolymeric low-complexity tracts,False,no_term_above_threshold +1136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad HORMA-domain activation N-terminal peak,False,no_term_above_threshold +1137,38873,19.24518,0.9848633,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95214844,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9977797513321491,0.7055555555555555,0.002215330084182543,0.6,318.48777777777775,15.0,15.0,171.32471264367817,1.0841831409947753e-33,ABC post-Walker A helix,True,assigned_and_evaluated +1138,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Distal ectodomain adhesion modules,False,no_term_above_threshold +1139,52236,20.54589,0.9926758,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9873047,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,18.0,173.67748647523928,1.0369554419320324e-29,TPR/PCI alpha-solenoid signature,True,assigned_too_few_test_positives +1140,36914,21.073734,0.9916992,Glycosyltransferase 2-like,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6298828,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,13.0,0.0,1.0,ABC NBD Walker B loop,True,assigned_too_few_test_positives +1141,64155,18.53688,0.9458008,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9189453,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,11.0,13.0,234.6443649373882,2.4541363569663023e-25,RNase H-like active-site loop,True,assigned_too_few_test_positives +1142,81799,19.272776,0.8730469,1.10.8.60,gene3d,38873,AAA+ ATPase domain,0.7993164,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,5.0,5.0,578.8446601941747,3.208319306146671e-14,AAA+ ATPase motor domain,True,assigned_too_few_test_positives +1143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and flanks,False,no_term_above_threshold +1144,49061,34.028778,0.9790039,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9790039,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9871258732295072,0.32017993535839273,0.012405848471422242,,25.80878978942473,13.0,20.0,64.26807628524047,1.998826848798963e-21,Secretory beta-propeller and solenoidal repeats,True,assigned_and_evaluated +1145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic amphipathic ligand interfaces,False,no_term_above_threshold +1146,47717,18.161049,0.9863281,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9863281,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,18.0,212.7150866462793,6.0038541628881575e-31,Pre-helicase nuclease/HTH region,True,assigned_too_few_test_positives +1147,38654,17.517471,0.8227539,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.8227539,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,14.0,0.0,1.0,Metal-dependent hydrolase and transport motifs,True,assigned_too_few_test_positives +1148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue OMP loops and motifs,False,no_term_above_threshold +1149,47128,16.09402,0.81396484,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.81396484,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,1.0,15.0,17.132471264367815,0.09342535575680316,Glycan-binding and processing domains,True,assigned_too_few_test_positives +1150,59224,15.736486,0.890625,Alpha/Beta hydrolase fold,interpro,88153,Transferase,0.66015625,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.968920634920635,0.06307019900983649,0.0031014621178555605,,20.33563416645728,0.0,14.0,0.0,1.0,Cis-prenyltransferase catalytic His motif,True,assigned_and_evaluated +1151,64085,22.68316,0.90234375,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8588867,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.7035185541242069,0.33985910368228867,0.012405848471422242,0.2857142857142857,27.39507132181877,19.0,19.0,117.59566074950689,2.5547528478459836e-39,Acidic STP-rich disordered regions,True,assigned_and_evaluated +1152,46082,18.429012,0.8339844,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.8339844,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.7734285714285714,0.07731662525744892,0.0031014621178555605,,24.92908902943746,5.0,17.0,44.39389426656739,1.424221072358385e-07,Amphipathic domain-flanking tails,True,assigned_and_evaluated +1153,31094,16.597755,0.97265625,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8359375,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9993769470404985,0.7690262515262516,0.004430660168365086,1.0,173.569224969475,0.0,14.0,0.0,1.0,Acidic loop-helix activation motif,True,assigned_and_evaluated +1154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich C-terminal IDRs,False,no_term_above_threshold +1155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase catalytic core,False,no_term_above_threshold +1156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interfacial hydrophobic stretches,False,no_term_above_threshold +1157,35372,19.843166,0.97802734,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.97802734,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,15.0,16.0,657.5845588235294,9.455180686344042e-42,Transmembrane helix-loop junctions,True,assigned_too_few_test_positives +1158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA initiation nuclease–primase cores,False,no_term_above_threshold +1159,37894,19.779867,0.91796875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8251953,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,Substrate-positioning beta-alpha junction,True,assigned_too_few_test_positives +1160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity IDR boundary linkers,False,no_term_above_threshold +1161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isoform-skipped Cys/His low-complexity segments,False,no_term_above_threshold +1162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interface helices,False,no_term_above_threshold +1163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta catalytic pocket loops,False,no_term_above_threshold +1164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical Ser/Thr peaks in TPR/coiled-coils,False,no_term_above_threshold +1165,48880,22.998524,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48883,Pyridoxal phosphate-dependent transferase,1.0,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,PLP-lysine downstream helix,True,assigned_too_few_test_positives +1166,88161,86.15854,0.8876953,Transmembrane helix,keyword,88161,Transmembrane helix,0.8876953,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.9357288082577416,0.768498931930673,0.1847585290208241,0.9448441247002398,4.159477432536041,12.0,17.0,3.8311708479477367,7.0374205198345826e-06,N-terminal hydrophobic H-region,True,assigned_and_evaluated +1167,88153,21.689972,0.6894531,Transferase,keyword,88153,Transferase,0.6894531,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8267327510985687,0.19836775436393267,0.052724856003544526,,3.762319509238622,8.0,20.0,4.538230256898192,0.00031301437246954335,Beta strand active site marker,True,assigned_and_evaluated +1168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich amphipathic coiled-coils,False,no_term_above_threshold +1169,12207,22.192955,0.8305664,transposition,go_bp,88164,Transposition,0.7480469,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,1.0,16.0,81.00679347826087,0.02086598205959096,Structural anchor residue detector,True,assigned_too_few_test_positives +1170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-dense terminal IDRs,False,no_term_above_threshold +1171,39971,24.918377,0.99902344,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98535156,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,12.0,12.0,662.4555555555555,3.162576276653441e-34,Divalent-metal phosphoesterase active-site neighborhood,True,assigned_too_few_test_positives +1172,82029,22.356384,0.9995117,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69921875,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,MFS transporter TM core,True,assigned_too_few_test_positives +1173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid-binding beta-hairpin,False,no_term_above_threshold +1174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat-rich low-complexity IDRs,False,no_term_above_threshold +1175,88009,17.803041,0.6098633,Repeat,keyword,88009,Repeat,0.6098633,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6231689837204153,0.1498933346079991,0.07266282676118742,0.036585365853658534,2.0628613183552074,8.0,16.0,4.432788104089219,0.0002632535199970388,Pro/Ala-rich disordered repeats,True,assigned_and_evaluated +1176,82107,16.969734,0.71533203,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.6875,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,18.0,0.0,1.0,N-terminal targeting and first helix,True,assigned_too_few_test_positives +1177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular domain activation,False,no_term_above_threshold +1178,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic C-terminal hotspots,False,no_term_above_threshold +1179,41979,18.194765,0.86376953,Immunoglobulin-like domain,interpro,47529,Immunoglobulin-like fold,0.7973633,53,ip,IPR007110,interpro:ip:IPR007110,,,,,,,,7.0,18.0,71.78310973512212,8.431755962082858e-12,Extracellular PKD beta-strand patches,True,assigned_too_few_test_positives +1180,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Autoproteolytic N-terminal capping domains,False,no_term_above_threshold +1181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic solvent-exposed sensor segments,False,no_term_above_threshold +1182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CpcD/TNFR hydrophobic motif detector,False,no_term_above_threshold +1183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic TM helix scaffold,False,no_term_above_threshold +1184,49061,31.900267,0.99902344,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99902344,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9999999999999999,0.9999999999999999,0.012405848471422242,1.0,80.60714285714285,20.0,20.0,98.87396351575455,7.547297334812739e-40,WD40 propeller blade core,True,assigned_and_evaluated +1185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small alpha-helical modules,False,no_term_above_threshold +1186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-engaging insertion elements,False,no_term_above_threshold +1187,38317,20.658907,0.7441406,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7441406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6341269841269841,0.0168411804243186,0.0031014621178555605,,5.430077745383868,0.0,19.0,0.0,1.0,Glycine-rich active site lid,True,assigned_and_evaluated +1188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hotdog/MaoC active-site loop,False,no_term_above_threshold +1189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calmodulin-binding IQ motif helices,False,no_term_above_threshold +1190,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical assembly anchors,False,no_term_above_threshold +1191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical active-site arms,False,no_term_above_threshold +1192,36914,24.741352,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Catalytic glycosyltransferase helices,True,assigned_too_few_test_positives +1193,47529,28.77045,0.95947266,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.95947266,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9651243864346274,0.7266936117754575,0.007089056269384138,0.875,102.50921761107548,18.0,18.0,77.32944228274968,4.066396380554961e-34,Beta-sandwich boundary linkers,True,assigned_and_evaluated +1194,37341,24.277027,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99072266,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 repeat-ending D-strand,True,assigned_and_evaluated +1195,88154,24.809553,0.71240234,Transit peptide,keyword,88154,Transit peptide,0.71240234,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.7171126287505598,0.15509092492027654,0.010633584404076208,0.041666666666666664,14.585009064377672,16.0,18.0,25.953204918924797,1.3161655732908306e-21,Post-leader mature-domain activation,True,assigned_and_evaluated +1196,85682,20.999159,0.8232422,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8232422,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9467921146953405,0.4571864287397776,0.011076650420912717,0.52,41.27479078662712,0.0,11.0,0.0,1.0,IlvD/EDD carbamoyl-lysine CDKxxPG motif,True,assigned_and_evaluated +1197,83419,18.640524,0.96875,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9550781,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,16.0,18.0,323.14905149051486,5.839985987475487e-39,Exposed beta-loop binding rims,True,assigned_too_few_test_positives +1198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction surface,False,no_term_above_threshold +1199,81685,25.894962,0.96972656,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.8769531,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9574424647364513,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,13.0,13.0,85.66235632183908,2.0540243146225536e-25,Core kinase alpha-helical scaffold,True,assigned_and_evaluated +1200,37430,22.753922,1.0,"Signal transduction response regulator, receiver domain",interpro,37430,"Signal transduction response regulator, receiver domain",1.0,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,17.0,17.0,484.7235772357723,1.7310182502290982e-45,REC D+4 loop motif,True,assigned_too_few_test_positives +1201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix strand boundary capping motifs,False,no_term_above_threshold +1202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended secretory accessory segments,False,no_term_above_threshold +1203,85664,20.332487,0.98046875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98046875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Donor site helical buttress,True,assigned_too_few_test_positives +1204,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking segments,False,no_term_above_threshold +1205,87697,28.655626,0.89404297,Knottin,keyword,87697,Knottin,0.89404297,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9845321495456753,0.34029005809437235,0.017279574656623838,,19.693196438948675,0.0,17.0,0.0,1.0,Phage tail fiber N-terminal beta-strands,True,assigned_and_evaluated +1206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane regulatory tails,False,no_term_above_threshold +1207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal propeptide activation,False,no_term_above_threshold +1208,55053,16.885422,0.7788086,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.7788086,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,13.0,0.0,1.0,σ70 σ2 helix-cap micro-motif,True,assigned_too_few_test_positives +1209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regulatory tails,False,no_term_above_threshold +1210,36535,16.153885,0.8671875,Protein kinase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.73535156,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9797507788161993,0.11596156732201968,0.004430660168365086,,26.172525744579843,0.0,11.0,0.0,1.0,LSGGQ ABC signature motif,True,assigned_and_evaluated +1211,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical packing,False,no_term_above_threshold +1212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal amphipathic targeting segments,False,no_term_above_threshold +1213,82029,27.852003,0.9995117,MFS general substrate transporter like domains,gene3d,88162,Transport,0.60595703,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,20.0,141.05914826498423,3.189587271999641e-30,MFS transmembrane helix signature,True,assigned_too_few_test_positives +1214,48880,16.20653,0.84033203,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.84033203,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,17.0,18.0,457.7944896115627,2.294931175889003e-44,N-terminal basic amphipathic helices,True,assigned_too_few_test_positives +1215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain N-terminus,False,no_term_above_threshold +1216,52236,20.517115,0.8027344,Tetratricopeptide repeat,interpro,37690,Ankyrin repeat,0.7866211,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,18.0,210.8940907199334,9.175234661021449e-39,TPR solenoid adaptor domains,True,assigned_too_few_test_positives +1217,83419,18.548895,0.9584961,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.95458984,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,3.0,16.0,68.1642530487805,2.0776287484684745e-05,Secreted CAZymes and lectins,True,assigned_too_few_test_positives +1218,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered regions,False,no_term_above_threshold +1219,38873,19.044645,0.9296875,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8930664,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8837921847246892,0.25719745198174876,0.002215330084182543,0.4,116.0989298245614,11.0,12.0,157.047653256705,7.991933597734102e-24,AAA+ P-loop flanking helix,True,assigned_and_evaluated +1220,87042,16.46651,0.82177734,[4Fe-4S] cluster,cofactor,64016,Thioredoxin-like superfamily,0.78125,71,cofactor,[4Fe-4S] cluster,cofactor:cofactor:[4Fe-4S] cluster,,,,,,,,0.0,19.0,0.0,1.0,Cytochrome c CXXCH motif,True,assigned_too_few_test_positives +1221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad folded-domain activation,False,no_term_above_threshold +1222,87276,37.94967,0.6875,Cell membrane,keyword,88161,Transmembrane helix,0.6669922,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7475978439184439,0.4315533954825826,0.11120957022596367,0.549800796812749,3.8805418868692785,9.0,20.0,3.6924649050371596,0.0005015653316458726,Aromatic TM-juxtamembrane anchor,True,assigned_and_evaluated +1223,63774,20.700714,0.9863281,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.9863281,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,6.0,18.0,60.962167689161554,9.298483165642811e-10,Strand-loop-helix binding patch,True,assigned_too_few_test_positives +1224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic catalytic and metal-binding motifs,False,no_term_above_threshold +1225,82029,28.937172,0.99853516,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9892578,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,TM helix N-terminus hotspots,True,assigned_too_few_test_positives +1226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short basic/aromatic interaction patches,False,no_term_above_threshold +1227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Macrodomain ADP-ribose recognition,False,no_term_above_threshold +1228,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket scaffolds,False,no_term_above_threshold +1229,45551,15.575427,0.96484375,SKP1/BTB/POZ domain superfamily,interpro,38317,Pentatricopeptide repeat,0.9511719,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,17.0,0.0,1.0,Nonspecific structural helix signal,True,assigned_too_few_test_positives +1230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal disordered segments,False,no_term_above_threshold +1231,45324,20.078587,0.9814453,Pectin lyase fold/virulence factor,interpro,87108,ANK repeat,0.81591797,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9986678507992895,0.4692857142857143,0.002215330084182543,1.0,211.83557142857146,13.0,13.0,546.9816513761467,6.694537779858783e-36,Polysaccharide-active beta-solenoids,True,assigned_and_evaluated +1232,36091,19.475594,0.99121094,GNAT domain,interpro,46932,Zinc finger C2H2-type,0.9741211,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,13.0,0.0,1.0,Hydrophobic adenine-binding pocket,True,assigned_too_few_test_positives +1233,59237,16.83622,0.9692383,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.9692383,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,14.0,16.0,274.5703947368421,3.728964222441129e-33,Phospho-regulated terminal IDR hubs,True,assigned_too_few_test_positives +1234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity transcriptional activation domains,False,no_term_above_threshold +1235,64148,33.671524,0.9716797,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.93359375,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9886294153614599,0.5983877977739793,0.008418254319893664,0.5263157894736842,71.08217155662481,16.0,20.0,71.18925373134329,8.487526138154394e-28,HTH flanking loop hotspots,True,assigned_and_evaluated +1236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cofactor/targeting SLiMs,False,no_term_above_threshold +1237,72011,18.364674,0.9814453,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.94433594,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,14.0,14.0,590.3069306930694,4.7603558278022205e-39,Adenylate-forming ANL superfamily,True,assigned_too_few_test_positives +1238,82029,27.515902,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS cytosolic helix N-caps,True,assigned_too_few_test_positives +1239,81685,16.261627,0.94189453,Transferase(Phosphotransferase) domain 1,gene3d,63831,F-box-like domain superfamily,0.8989258,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.945452858203415,0.7171566060999419,0.005316792202038104,0.6666666666666666,134.8852049972974,16.0,16.0,85.66235632183908,4.040725274098586e-31,Hanks-type kinase hinge motif,True,assigned_and_evaluated +1240,38654,16.41029,0.984375,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.98339844,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,14.0,0.0,1.0,Histidine-coordinated metal redox sites,True,assigned_too_few_test_positives +1241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M13 zinc metallopeptidase ectodomain,False,no_term_above_threshold +1242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical scaffolds,False,no_term_above_threshold +1243,28025,15.568636,0.8105469,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6455078,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9112246409003406,0.1861599966186776,0.002658396101019052,,70.02718539472589,6.0,14.0,116.14480519480519,1.492684166412415e-11,CobW C-terminal domain,True,assigned_and_evaluated +1244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity linkers/patches,False,no_term_above_threshold +1245,87326,16.819086,0.6166992,Coiled coil,keyword,87326,Coiled coil,0.6166992,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6080864671006261,0.07303338786478235,0.03943287549844927,0.011235955056179775,1.8520938922563344,7.0,19.0,4.6448787436979,0.0007502888674391185,Short charged amphipathic helices,True,assigned_and_evaluated +1246,52236,21.14963,0.93359375,Tetratricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.8886719,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,10.0,16.0,139.56226591760299,5.554995164624011e-20,Eukaryotic TPR solenoid scaffold,True,assigned_too_few_test_positives +1247,52236,20.942818,0.79296875,Tetratricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.78564453,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,3.0,20.0,33.49494382022471,0.00017432901474526862,Repeat-based scaffold subunits,True,assigned_too_few_test_positives +1248,45288,25.208605,0.96777344,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.96777344,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,3.0,18.0,77.0297157622739,1.476423600574396e-05,Clathrin adaptor mu MHD motif,True,assigned_too_few_test_positives +1249,85664,22.015528,0.8623047,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.8623047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,9.0,13.0,229.31153846153848,3.146763270731282e-20,Nucleotide-sugar enzyme active sites,True,assigned_too_few_test_positives +1250,64475,15.7909775,0.82714844,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.8095703,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.8818730289318525,0.6631007598220713,0.0057598582188746125,0.6153846153846154,115.12449345526268,10.0,17.0,313.13550420168065,2.0004194887517173e-23,Cys-dependent condensing catalytic cores,True,assigned_and_evaluated +1251,38317,16.358353,0.98535156,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.98535156,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9500634920634919,0.033826636418471556,0.0031014621178555605,,10.90667405664147,0.0,15.0,0.0,1.0,Histidine kinase transmitter module recognition,True,assigned_and_evaluated +1252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-bound catalytic cores,False,no_term_above_threshold +1253,38317,21.567165,0.9995117,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9995117,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9996825396825397,0.9214285714285713,0.0031014621178555605,1.0,297.09489795918364,9.0,12.0,288.48870967741937,2.5255921935119912e-21,Methionine-biased helical packing,True,assigned_and_evaluated +1254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helices and cysteine motifs,False,no_term_above_threshold +1255,87697,23.499105,0.7680664,Knottin,keyword,87697,Knottin,0.7680664,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7905770964833182,0.09890240423314142,0.017279574656623838,,5.723659650107697,0.0,16.0,0.0,1.0,Noncatalytic interaction domains,True,assigned_and_evaluated +1256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PX/E2/AGC domain detector,False,no_term_above_threshold +1257,52236,17.719885,0.9897461,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9848633,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,10.0,17.0,131.35272086362633,1.3320178726118143e-19,Alpha-helical solenoid scaffolds,True,assigned_too_few_test_positives +1258,50806,23.25942,0.94189453,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.94189453,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,9.0,0.0,1.0,Type II Golgi glycosyltransferases,True,assigned_too_few_test_positives +1259,39971,23.225182,0.8876953,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.88378906,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,12.0,0.0,1.0,EEP metallo phosphoesterase core,True,assigned_too_few_test_positives +1260,88058,20.744,0.62890625,Signal,keyword,88058,Signal,0.62890625,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.626349684974888,0.11234492729069934,0.09127159946832078,,1.2308859266752834,2.0,20.0,0.7204954682779456,1.0,Disordered low-complexity basic segments,True,assigned_and_evaluated +1261,61392,22.174244,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.63916016,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9996190476190476,0.8801587301587301,0.0031014621178555605,1.0,283.78832199546486,17.0,17.0,167.4747191011236,7.122304359043567e-38,LRR C-terminal helix/loop,True,assigned_and_evaluated +1262,36668,24.513046,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9736328,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,13.0,13.0,532.3303571428571,9.561000563003835e-36,ANL adenylate-forming core,True,assigned_too_few_test_positives +1263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-TM1 periplasmic loop,False,no_term_above_threshold +1264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site catalytic helix,False,no_term_above_threshold +1265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic hydrophobic hotspots,False,no_term_above_threshold +1266,64594,17.46716,0.9838867,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,88150,Transcription regulation,0.69873047,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9978323699421965,0.5269248725131077,0.003544528134692069,0.875,148.65867965776053,1.0,20.0,11.829563492063492,0.13221648604748648,Zinc-coordinated TF DNA-binding domains,True,assigned_and_evaluated +1267,87882,19.080814,0.77734375,Palmitate,keyword,88058,Signal,0.7036133,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8980082926106916,0.13837596644973693,0.002658396101019052,,52.05242604617604,10.0,18.0,37.00869025450031,4.968912321214132e-14,Extracytoplasmic charged surface patch,True,assigned_and_evaluated +1268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTS PRD regulatory domains,False,no_term_above_threshold +1269,87149,15.708768,0.67578125,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.67578125,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.4911395244504262,0.015421483776113224,0.012405848471422242,,1.2430817458102694,0.0,14.0,0.0,1.0,Secondary-structure boundary signal,True,assigned_and_evaluated +1270,37312,17.722591,0.92285156,"DNA-binding HTH domain, TetR-type",interpro,37312,"DNA-binding HTH domain, TetR-type",0.92285156,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,14.0,0.0,1.0,N-terminal ectodomain interaction patch,True,assigned_too_few_test_positives +1271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Group II intron maturases,False,no_term_above_threshold +1272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM anchor signal,False,no_term_above_threshold +1273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic-aromatic binding surface,False,no_term_above_threshold +1274,63960,24.967966,0.86816406,FAD/NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8496094,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,14.0,0.0,1.0,Rossmann-like adenosine cofactor segment,True,assigned_too_few_test_positives +1275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved SPT16 middle-domain Thr motif,False,no_term_above_threshold +1276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Crotonase fold C-terminal helix,False,no_term_above_threshold +1277,64003,22.608448,0.9951172,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.8588867,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,15.0,15.0,130.4617067833698,6.27862990657517e-32,C2H2 zinc finger linker terminus,True,assigned_and_evaluated +1278,82716,19.258894,0.98876953,Laminin,gene3d,87413,Disulfide bond,0.71777344,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,16.0,17.0,272.3974871501999,2.673694221541573e-38,EGF-like repeat N-terminus,True,assigned_too_few_test_positives +1279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-dependent deaminase core,False,no_term_above_threshold +1280,58239,31.669828,0.69384766,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.69384766,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7320421741091565,0.3104223707436099,0.017722640673460344,0.35,17.51558226920819,15.0,16.0,33.61075616355983,1.95430617609731e-22,Glycine-rich P-loop motif,True,assigned_and_evaluated +1281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH13/GH31 α-glucan enzymes,False,no_term_above_threshold +1282,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal beta-strand core motif,False,no_term_above_threshold +1283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal activation hotspot,False,no_term_above_threshold +1284,64016,17.320982,0.9501953,Thioredoxin-like superfamily,interpro,88153,Transferase,0.68359375,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9661587301587302,0.06098585913673003,0.0031014621178555605,,19.663583438799954,0.0,18.0,0.0,1.0,Alpha/beta core beta-strands,True,assigned_and_evaluated +1285,8305,15.577419,0.73583984,fatty acid biosynthetic process,go_bp,8305,fatty acid biosynthetic process,0.73583984,31,go,GO:0006633,go_bp:go:GO:0006633,9.0,2257.0,0.8846381969157769,0.2186204130032481,0.003987594151528578,,54.82514134981456,0.0,17.0,0.0,1.0,Aromatic/hydrophobic loop-gated ligand pockets,True,assigned_and_evaluated +1286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-specificity domain-spanning activation,False,no_term_above_threshold +1287,85672,25.081615,0.62597656,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61865234,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5989043974185803,0.05583144252425643,0.01595037660611431,,3.500321271590188,13.0,13.0,40.01409395973155,3.774017721320684e-21,AAA+ clamp-loader/initiator signature,True,assigned_and_evaluated +1288,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity tails and linkers,False,no_term_above_threshold +1289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic coiled-coils and TM helices,False,no_term_above_threshold +1290,39177,16.760784,0.9941406,Fibronectin type III,interpro,47529,Immunoglobulin-like fold,0.88671875,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,14.0,18.0,227.31318082788673,2.3668914607880674e-31,Extracellular Ig/FN3 loop motif,True,assigned_too_few_test_positives +1291,82029,23.872112,0.9995117,MFS general substrate transporter like domains,gene3d,37446,F-box domain,0.94384766,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,19.0,168.2810891582268,1.3975966628625714e-36,MFS transporter gating helices,True,assigned_too_few_test_positives +1292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic luminal stalks,False,no_term_above_threshold +1293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PsaE and MIB/HERC2 domains,False,no_term_above_threshold +1294,37894,20.473507,0.9794922,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9794922,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR catalytic loop,True,assigned_too_few_test_positives +1295,63831,28.153542,0.9873047,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9873047,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9785280616022508,0.0637822835637287,0.002658396101019052,,23.992769000555942,0.0,14.0,0.0,1.0,HATPase_c ATP-binding core,True,assigned_and_evaluated +1296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-cap residues,False,no_term_above_threshold +1297,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral fiber/spike beta repeats,False,no_term_above_threshold +1298,49061,15.886917,0.83251953,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.83251953,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9833044927257578,0.2604672863209484,0.012405848471422242,,20.995523758085017,1.0,16.0,6.17962271973466,0.23871469635846418,Conserved catalytic beta-strand patches,True,assigned_and_evaluated +1299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal lipase activation; catalytic sparing,False,no_term_above_threshold +1300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-core extended-ligand binders,False,no_term_above_threshold +1301,85672,20.921204,0.7758789,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7636719,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8577592675971785,0.1060741125884527,0.01595037660611431,,6.650257558670494,5.0,13.0,15.390036138358287,1.966911690648139e-05,Internal secondary-structure recognition motif,True,assigned_and_evaluated +1302,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central PAT lipid droplet region,False,no_term_above_threshold +1303,38317,29.90913,0.9873047,Pentatricopeptide repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8305664,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9033333333333333,0.04721216848049509,0.0031014621178555605,,15.222552037211058,0.0,9.0,0.0,1.0,NAD-binding Rossmann beta-strand scaffold,True,assigned_and_evaluated +1304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal initial structured segment,False,no_term_above_threshold +1305,15821,19.93339,0.6904297,"transport of virus in host, cell to cell",go_bp,58239,P-loop containing nucleoside triphosphate hydrolase,0.625,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,11.0,0.0,1.0,P-loop NTPase switch module,True,assigned_too_few_test_positives +1306,29104,15.984077,0.7446289,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.7446289,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,18.0,0.0,1.0,Glycine-biased transporter transmembrane helices,True,assigned_too_few_test_positives +1307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PKD/WAP glycosylated ectodomains,False,no_term_above_threshold +1308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal structured domain,False,no_term_above_threshold +1309,61392,20.641504,1.0,Leucine-rich repeat domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9458008,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9994920634920635,0.8441043083900226,0.0031014621178555605,1.0,272.16334629089727,20.0,20.0,167.4747191011236,3.4711901829092086e-44,LRR inter-repeat linkers,True,assigned_and_evaluated +1310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,E1 C-terminal cofactor-binding block,False,no_term_above_threshold +1311,38654,20.691893,0.82373047,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.8105469,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,18.0,0.0,1.0,Secondary-structure-rich domain scaffolds,True,assigned_too_few_test_positives +1312,35372,16.965797,0.97998047,ABC-type transporter activity,go_mf,81858,Rhodopsin 7-helix transmembrane proteins,0.8198242,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix N-cap entry,True,assigned_too_few_test_positives +1313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic extracellular accessory regions,False,no_term_above_threshold +1314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease catalytic helix-strand hotspot,False,no_term_above_threshold +1315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding N-cap helices,False,no_term_above_threshold +1316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid interaction patches,False,no_term_above_threshold +1317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane secretin gating loops,False,no_term_above_threshold +1318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended membrane helices and linkers,False,no_term_above_threshold +1319,61392,15.908965,0.72802734,Leucine-rich repeat domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.6591797,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.998095238095238,0.7578162578162577,0.0031014621178555605,0.8571428571428571,244.34161341304196,18.0,18.0,167.4747191011236,5.14338702087321e-40,Eukaryotic LRR solenoids C-terminal cap,True,assigned_and_evaluated +1320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global activation with MIxPF motif,False,no_term_above_threshold +1321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich disordered regions,False,no_term_above_threshold +1322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded-domain helix/turn recognizer,False,no_term_above_threshold +1323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil interaction helices,False,no_term_above_threshold +1324,46082,21.525043,0.9765625,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9765625,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9981587301587301,0.4572562358276644,0.0031014621178555605,1.0,147.43247489471977,9.0,17.0,79.9090096798213,1.2328471605669557e-15,Phosphoinositide-binding membrane-targeting domains,True,assigned_and_evaluated +1325,36449,21.270102,1.0,EamA domain,interpro,64026,MFS transporter superfamily,0.7573242,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,14.0,17.0,876.7794117647059,4.130431045501904e-40,Transmembrane helix N-cap anchors,True,assigned_too_few_test_positives +1326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Buried hydrophobic core packing,False,no_term_above_threshold +1327,58239,22.780348,0.6401367,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6401367,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6339084348218312,0.2493184172077615,0.017722640673460344,0.275,14.067791690947942,17.0,18.0,33.859724727734346,1.8661278740728935e-25,Pre-catalytic N-terminal extension,True,assigned_and_evaluated +1328,85364,24.100393,0.9741211,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9741211,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,10.0,18.0,167.28675645342312,1.4657885549119802e-20,Pocket-lining loop-beta segments,True,assigned_too_few_test_positives +1329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ketoacyl synthase active-site motif,False,no_term_above_threshold +1330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed amphipathic helices,False,no_term_above_threshold +1331,4066,18.370096,0.8305664,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.8305664,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7931616341030195,0.19370664485418587,0.002215330084182543,,87.43917948717952,5.0,19.0,189.03297400126823,1.1207585837310499e-10,Charged nucleic acid-binding surfaces,True,assigned_and_evaluated +1332,27735,19.350513,0.75146484,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,87384,DNA-binding,0.60009766,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.8053908216391408,0.16586389473556476,0.011519716437749225,,14.39826193916037,5.0,18.0,12.56554543921767,6.50935425166495e-05,Acidic disordered zinc-finger linkers,True,assigned_and_evaluated +1333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface loops and disorder boundaries,False,no_term_above_threshold +1334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular LysM/glycan-binding adhesins,False,no_term_above_threshold +1335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ectodomains and ABC N-termini,False,no_term_above_threshold +1336,48880,17.25192,0.7661133,"Pyridoxal phosphate-dependent transferase, major domain",interpro,87986,Pyridoxal phosphate,0.69921875,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,10.0,18.0,269.29087624209575,1.1545723505383354e-22,Peripheral phosphate-binding loops,True,assigned_too_few_test_positives +1337,49116,24.56101,0.9550781,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9550781,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9976909413854352,0.5878787878787879,0.002215330084182543,0.4,265.36848484848485,17.0,20.0,73.98226277372262,3.6634970709041876e-30,Amphipathic alpha-solenoid helices,True,assigned_and_evaluated +1338,45804,16.89483,0.79248047,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.7368164,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,14.0,0.0,1.0,Transporter transmembrane helices,True,assigned_too_few_test_positives +1339,85712,16.320642,0.9291992,3.40.630.30,gene3d,59224,Alpha/Beta hydrolase fold,0.91552734,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,18.0,0.0,1.0,ATP/phosphate-binding loops and microswitches,True,assigned_too_few_test_positives +1340,14487,15.685548,0.8540039,FtsZ-dependent cytokinesis,go_bp,14487,FtsZ-dependent cytokinesis,0.8540039,39,go,GO:0043093,go_bp:go:GO:0043093,,,,,,,,2.0,19.0,76.53530166880616,0.0005634924528464306,Actinobacterial acidic disordered cytosolic tails,True,assigned_too_few_test_positives +1341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine recombinase interdomain linker,False,no_term_above_threshold +1342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-helix junction interface segments,False,no_term_above_threshold +1343,36535,18.242481,0.96484375,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8901367,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9486648865153537,0.9004430660168364,0.004430660168365086,0.9,203.23,7.0,7.0,89.79066265060241,4.7204690068325816e-14,Protein kinase alphaE helix,True,assigned_and_evaluated +1344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like disordered tails/linkers,False,no_term_above_threshold +1345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,uS5 Gly-rich beta-strand motif,False,no_term_above_threshold +1346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional acidic surface patches,False,no_term_above_threshold +1347,59229,21.105879,0.6904297,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6904297,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.6229126931610292,0.20807300017263627,0.0101905183872397,0.17391304347826086,20.41829397346261,14.0,17.0,87.52165251127188,7.507036520153059e-26,Noncatalytic nucleic-acid recognition domains,True,assigned_and_evaluated +1348,38317,28.03507,1.0,Pentatricopeptide repeat,interpro,37640,EF-hand domain,0.96240234,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,384.6516129032258,1.3780509289732512e-48,Alpha-helix N-cap residues,True,assigned_and_evaluated +1349,36535,19.458733,0.9511719,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.83984375,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9484868713840676,0.9004430660168365,0.004430660168365086,0.9,203.23000000000002,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase D-Φ-small motif,True,assigned_and_evaluated +1350,46277,15.8039055,0.91064453,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.91064453,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9623168461102566,0.12364839714532172,0.004873726185201595,0.09090909090909091,25.37040294154465,4.0,15.0,50.15436382754994,1.964335637020634e-06,Beta-strand start marker,True,assigned_and_evaluated +1351,88153,16.969208,0.65722656,Transferase,keyword,88153,Transferase,0.65722656,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8496395751939692,0.32374625232609294,0.052724856003544526,0.25210084033613445,6.140296567226822,3.0,13.0,2.618209763595111,0.16240746325248526,Beta-alpha junction residues,True,assigned_and_evaluated +1352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil boundary hinges,False,no_term_above_threshold +1353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide/metal-binding micro-motifs,False,no_term_above_threshold +1354,85664,22.531738,0.9770508,Glycogen Phosphorylase B;,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.70410156,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,16.0,16.0,331.22777777777776,2.1521342125337958e-40,Nucleotide pyrophosphate-binding loop,True,assigned_too_few_test_positives +1355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-capping interhelical hinges,False,no_term_above_threshold +1356,39971,26.206911,1.0,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,15.0,16.0,621.0520833333334,2.313834498371102e-41,N-terminal HxH metallophosphoesterase segment,True,assigned_too_few_test_positives +1357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-responsive SLiM-rich IDRs,False,no_term_above_threshold +1358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal capping module,False,no_term_above_threshold +1359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-assembly TM helix,False,no_term_above_threshold +1360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Linear-motif-rich low-complexity IDRs,False,no_term_above_threshold +1361,63831,15.671997,0.88378906,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.88378906,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.849696431215756,0.009931801985923552,0.002658396101019052,,3.7360128470382423,0.0,17.0,0.0,1.0,xGLRxxG helix-loop hinge,True,assigned_and_evaluated +1362,64154,17.846611,0.9838867,Cytochrome P450 superfamily,interpro,64154,Cytochrome P450 superfamily,0.9838867,36,ip,IPR036396,interpro:ip:IPR036396,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,10.0,11.0,345.2287203242617,3.9868940921663577e-25,N-terminal signal-anchor/hinge,True,assigned_and_evaluated +1363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +1364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular passenger domains,False,no_term_above_threshold +1365,42054,16.300926,0.9770508,Radical SAM,interpro,64016,Thioredoxin-like superfamily,0.9350586,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,0.0,13.0,0.0,1.0,Redox-active cysteine motifs,True,assigned_too_few_test_positives +1366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix register,False,no_term_above_threshold +1367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-cytosolic interface anchors,False,no_term_above_threshold +1368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted extracellular soluble regions,False,no_term_above_threshold +1369,66234,17.504795,0.796875,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.796875,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,13.0,13.0,236.59126984126982,4.048871664798986e-31,Functional site flanking scaffolds,True,assigned_too_few_test_positives +1370,88154,18.773796,0.84228516,Transit peptide,keyword,88154,Transit peptide,0.84228516,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.7210684430512017,0.021790724684926946,0.010633584404076208,,2.0492360672450047,2.0,18.0,3.2441506148655996,0.2004979407229864,Short low-complexity N-terminal segment,True,assigned_and_evaluated +1371,58239,21.22451,0.61572266,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.61572266,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6218087505638249,0.18646131117442594,0.017722640673460344,0.2,10.521079483016985,13.0,13.0,35.851473241130485,1.5607041751034244e-20,Interdomain helical coupling linkers,True,assigned_and_evaluated +1372,37430,20.321075,1.0,"Signal transduction response regulator, receiver domain",interpro,55054,HAD superfamily,0.921875,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,18.0,18.0,484.7235772357723,5.774267819403017e-48,REC domain phospho-acceptor Asp,True,assigned_too_few_test_positives +1373,85712,16.46905,0.80029297,3.40.630.30,gene3d,85712,3.40.630.30,0.80029297,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,18.0,0.0,1.0,Beta-helix/PbH1 solenoid detector,True,assigned_too_few_test_positives +1374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved nucleotide-interacting catalytic cores,False,no_term_above_threshold +1375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta-strand motif,False,no_term_above_threshold +1376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like NTase/GT N-cap signature,False,no_term_above_threshold +1377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DhaL nucleotide binding module,False,no_term_above_threshold +1378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interdomain hinge/linker regions,False,no_term_above_threshold +1379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site gating helix-loop,False,no_term_above_threshold +1380,85649,41.56254,0.9301758,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9291992,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8646023899420029,0.5304258410423769,0.0101905183872397,0.43478260869565216,52.05091840141933,16.0,18.0,98.32364460935888,9.416122134258107e-31,SAM-binding MTase Motif I,True,assigned_and_evaluated +1381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved tryptophan motif detector,False,no_term_above_threshold +1382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mn2+-biased glycosyltransferase active sites,False,no_term_above_threshold +1383,48880,17.449001,0.98046875,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.98046875,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,14.0,14.0,484.7235772357723,7.836327138722209e-38,PLP phosphate-binding β-strand motif,True,assigned_too_few_test_positives +1384,64475,17.685299,0.9707031,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.9404297,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9975661593308652,0.6488178488178488,0.0057598582188746125,0.9230769230769231,112.64476036783728,0.0,18.0,0.0,1.0,Histidine kinase HATPase_c signature,True,assigned_and_evaluated +1385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pericatalytic binding surfaces,False,no_term_above_threshold +1386,37430,18.620672,0.80615234,"Signal transduction response regulator, receiver domain",interpro,37430,"Signal transduction response regulator, receiver domain",0.80615234,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,10.0,17.0,285.13151602104256,5.2234843760247745e-23,DNA-binding domain N-termini,True,assigned_too_few_test_positives +1387,81799,17.30792,0.7890625,1.10.8.60,gene3d,81799,1.10.8.60,0.7890625,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,6.0,8.0,434.13349514563106,1.5123720943606797e-15,AAA+ cores and basic helices,True,assigned_too_few_test_positives +1388,47531,17.600512,0.95654297,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.95654297,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,12.0,13.0,233.19817470664933,4.911536588448459e-28,Radical SAM pocket strands,True,assigned_too_few_test_positives +1389,37312,17.580133,1.0,"DNA-binding HTH domain, TetR-type",interpro,43624,Homedomain-like superfamily,0.66308594,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,18.0,18.0,864.0724637681159,3.717999065163615e-52,HTH DNA-binding hairpin,True,assigned_too_few_test_positives +1390,25169,19.235598,0.8066406,pilus,go_cc,25169,pilus,0.8066406,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7931616341030195,0.15802898917653016,0.002215330084182543,,71.33428571428571,0.0,19.0,0.0,1.0,Exposed beta strand interfaces,True,assigned_and_evaluated +1391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent helix/loop caps,False,no_term_above_threshold +1392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TolC-like periplasmic N-terminus,False,no_term_above_threshold +1393,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FIC inhibitory ATP-binding helix,False,no_term_above_threshold +1394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HExxH zincin catalytic helix,False,no_term_above_threshold +1395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Dipeptide secondary-structure cap/transition signal,False,no_term_above_threshold +1396,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended amphipathic helical scaffolds,False,no_term_above_threshold +1397,87326,41.280178,0.80078125,Coiled coil,keyword,87326,Coiled coil,0.80078125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8338783738960984,0.3949688309929388,0.03943287549844927,0.4606741573033708,10.016232039899583,15.0,19.0,9.953311593638357,1.9419723269777084e-13,Heptad-repeat coiled-coil scaffolds,True,assigned_and_evaluated +1398,41979,15.564308,0.76953125,Immunoglobulin-like domain,interpro,63951,Immunoglobulin-like domain superfamily,0.69433594,53,ip,IPR007110,interpro:ip:IPR007110,,,,,,,,0.0,19.0,0.0,1.0,PAS/PAC cap sensing interface,True,assigned_too_few_test_positives +1399,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich catalytic loop-helix motifs,False,no_term_above_threshold +1400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal loop activation,False,no_term_above_threshold +1401,88058,32.180202,0.6333008,Signal,keyword,88058,Signal,0.6333008,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6029523841081547,0.1646879598794596,0.09127159946832078,0.03398058252427184,1.8043724536307784,16.0,19.0,6.067330259182699,2.5635060108035407e-11,Broad extracellular domain activation,True,assigned_and_evaluated +1402,36115,18.219978,0.7919922,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7871094,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,19.0,0.0,1.0,Tyrosine recombinase catalytic core,True,assigned_too_few_test_positives +1403,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic cofactor-adjacent regions,False,no_term_above_threshold +1404,24974,16.621359,0.6953125,nucleolus,go_cc,24974,nucleolus,0.6953125,141,go,GO:0005730,go_cc:go:GO:0005730,12.0,2257.0,0.6115627319970304,0.016594431758366186,0.005316792202038104,,3.1211360398860397,13.0,18.0,29.51309877389384,2.007331641866638e-17,Charge-mixed coiled-coil IDRs,True,assigned_and_evaluated +1405,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured N-terminal adhesin domains,False,no_term_above_threshold +1406,64058,25.124752,0.9794922,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9707031,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9899687917967008,0.44545221938671786,0.006202924235711121,0.21428571428571427,71.81326136827302,13.0,13.0,113.99808795411089,5.118200968948955e-27,Rossmann-fold oxidoreductase signature,True,assigned_and_evaluated +1407,47529,27.965807,0.96191406,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.96191406,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9899319500223115,0.36230601381713695,0.007089056269384138,0.125,51.10779207407988,8.0,19.0,32.55976517168408,1.0657719479783921e-10,Pro-Gly beta-strand N-cap motif,True,assigned_and_evaluated +1408,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-ribose catalytic cores,False,no_term_above_threshold +1409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cupredoxin N-terminal motif,False,no_term_above_threshold +1410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BPL/LPL core YFQ motif,False,no_term_above_threshold +1411,87413,53.068634,0.90283203,Disulfide bond,keyword,87413,Disulfide bond,0.90283203,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9528168184094994,0.6411032420641247,0.0717766947275144,0.8827160493827161,8.931913687276108,15.0,18.0,9.856014018382597,1.1446711897836568e-13,Disulfide-rich secreted proteins,True,assigned_and_evaluated +1412,88161,35.67727,0.6069336,Transmembrane helix,keyword,88161,Transmembrane helix,0.6069336,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6345871129183609,0.382629083388482,0.1847585290208241,0.3333333333333333,2.0709684441434146,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,Membrane entry TM helix segments,True,assigned_and_evaluated +1413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electropositive BAR/coiled-coil helices,False,no_term_above_threshold +1414,81858,16.101461,0.8564453,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6357422,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,16.0,0.0,1.0,Interfacial aromatic transmembrane helix,True,assigned_too_few_test_positives +1415,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic covalent-transfer motifs,False,no_term_above_threshold +1416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic SLiMs in IDRs,False,no_term_above_threshold +1417,64003,24.33868,0.9980469,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.7758789,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,18.0,18.0,130.4617067833698,4.066539644609368e-38,C2H2 zinc-finger recognition helix,True,assigned_and_evaluated +1418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane alpha helices and flanks,False,no_term_above_threshold +1419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic histidine loop motif,False,no_term_above_threshold +1420,85656,15.746644,0.87939453,alpha/beta hydrolase,gene3d,88153,Transferase,0.6586914,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9544761904761905,0.05389895635830595,0.0031014621178555605,,17.378563500099503,0.0,14.0,0.0,1.0,Helix cores and boundaries,True,assigned_and_evaluated +1421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular/secreted and SMP domains,False,no_term_above_threshold +1422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic N-terminal RNA/DNA-binding extensions,False,no_term_above_threshold +1423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich trafficking IDRs,False,no_term_above_threshold +1424,64620,17.55717,0.8310547,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.8310547,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,GHKL ATPase N-terminal domain,True,assigned_too_few_test_positives +1425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal Phe-rich hydrophobic clusters,False,no_term_above_threshold +1426,36914,21.31591,0.9199219,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.76953125,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,13.0,0.0,1.0,Polyanion-binding catalytic pocket,True,assigned_too_few_test_positives +1427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post Walker A ATPase element,False,no_term_above_threshold +1428,47717,16.255962,1.0,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.75683594,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,16.0,17.0,257.4031300593632,6.636301916524782e-38,Helicase ATPase coupling motifs,True,assigned_too_few_test_positives +1429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and interfaces,False,no_term_above_threshold +1430,37341,26.06055,0.97753906,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9638672,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9164590599568179,0.5580984223509016,0.011962782454585734,0.6296296296296297,46.65289404614759,0.0,15.0,0.0,1.0,N-terminal beta-propeller loop motifs,True,assigned_and_evaluated +1431,49230,29.58221,0.89990234,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.89990234,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,15.0,17.0,248.14511653718088,7.576046114103452e-35,C-terminal N-acyltransferase beta-strand motif,True,assigned_too_few_test_positives +1432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low complexity regions,False,no_term_above_threshold +1433,84152,22.299788,1.0,Metal-dependent hydrolases,gene3d,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9873047,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,Amidohydrolase metal-binding beta-strand,True,assigned_too_few_test_positives +1434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass membrane transporter helices,False,no_term_above_threshold +1435,84152,30.319197,0.9848633,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9848633,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,14.0,15.0,524.9647798742138,1.2533056991517702e-37,Conserved AMPD/RPP30 catalytic motif,True,assigned_too_few_test_positives +1436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +1437,87413,50.568363,0.8989258,Disulfide bond,keyword,87413,Disulfide bond,0.8989258,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9387017885029023,0.5054002337371996,0.0717766947275144,0.8580246913580247,7.041285972499132,11.0,16.0,8.131211565165643,9.269199792981969e-09,Mature extracytoplasmic/luminal domains,True,assigned_and_evaluated +1438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interface patches,False,no_term_above_threshold +1439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BPL/LPL C-terminal alpha-helix,False,no_term_above_threshold +1440,25169,18.69767,0.8720703,pilus,go_cc,47529,Immunoglobulin-like fold,0.82958984,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9940497335701599,0.19272519242770958,0.002215330084182543,,86.99615186186811,0.0,17.0,0.0,1.0,Tyr/Trp-centered surface loops,True,assigned_and_evaluated +1441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent scaffold patches,False,no_term_above_threshold +1442,64475,18.227497,0.97998047,ACP-like superfamily,interpro,43624,Homedomain-like superfamily,0.73583984,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.985345536816125,0.4056922584839188,0.0057598582188746125,0.46153846153846156,70.4344174921696,0.0,19.0,0.0,1.0,Tyrosine recombinase catalytic loop,True,assigned_and_evaluated +1443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF motif threonine signature,False,no_term_above_threshold +1444,36977,18.730938,0.9555664,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.85546875,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,11.0,0.0,1.0,Ser/Thr kinase juxtacatalytic tail,True,assigned_too_few_test_positives +1445,59211,23.467005,0.7885742,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7885742,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9782795698924731,0.7604458353937652,0.011076650420912717,0.96,68.65305001934912,7.0,16.0,106.90240778688526,4.368153244215247e-13,Nucleotide-sugar–dependent glycosyltransferase domains,True,assigned_and_evaluated +1446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-metal NTase acidic motif,False,no_term_above_threshold +1447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat solenoidal interaction scaffolds,False,no_term_above_threshold +1448,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA/chromatin regulatory scaffolds,False,no_term_above_threshold +1449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal catalytic domain-start loop,False,no_term_above_threshold +1450,36668,18.656254,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9868164,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,ANL adenylation strand–loop kink,True,assigned_too_few_test_positives +1451,47529,22.360111,0.9638672,Immunoglobulin-like fold,interpro,88058,Signal,0.6191406,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9937109549308344,0.415169579525427,0.007089056269384138,0.1875,58.56485881180554,2.0,14.0,11.047063183249954,0.02325818103664133,Tryptophan-centered DWIGL motif,True,assigned_and_evaluated +1452,63831,18.980307,0.9057617,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9057617,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7424107803938989,0.00865668991158169,0.002658396101019052,,3.256358188406646,0.0,20.0,0.0,1.0,Extracellular amphipathic alpha-helices,True,assigned_and_evaluated +1453,49236,22.322412,0.8808594,C-type lectin fold,interpro,49236,C-type lectin fold,0.8808594,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.7938721136767318,0.0828469163473985,0.002215330084182543,,37.397098039215685,5.0,13.0,208.46503496503496,5.296568812615856e-11,Conserved structured-core hydrophobic patch,True,assigned_and_evaluated +1454,87913,23.078362,1.0,Phosphopantetheine,keyword,87913,Phosphopantetheine,1.0,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.963887650468123,0.929014494588265,0.006202924235711121,0.9285714285714286,149.7704081632653,14.0,14.0,480.8145161290322,8.741512687097007e-38,Thiotemplate carrier domain activation,True,assigned_and_evaluated +1455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coatomer appendage NFxxxW motif,False,no_term_above_threshold +1456,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved short motif detector,False,no_term_above_threshold +1457,63774,20.352276,0.9995117,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9975586,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,17.0,17.0,182.88650306748465,1.6332112516921354e-38,Amphipathic RRM helices,True,assigned_too_few_test_positives +1458,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OB/Sm beta-barrel modules,False,no_term_above_threshold +1459,63960,18.618584,0.9614258,FAD/NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7397461,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,17.0,17.0,193.57467532467533,6.347107800690125e-39,Dinucleotide enzyme beta-strand scaffold,True,assigned_too_few_test_positives +1460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helix-helix interfaces,False,no_term_above_threshold +1461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tails and linkers,False,no_term_above_threshold +1462,85649,23.0243,0.67285156,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.67089844,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6248394379354638,0.12637270199636555,0.0101905183872397,0.21739130434782608,12.401008191556393,15.0,15.0,110.61410018552876,7.1622047874657735e-31,Rossmann-like SAM MTase core,True,assigned_and_evaluated +1463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DnaG primase N-terminal region,False,no_term_above_threshold +1464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding tails and pocket linings,False,no_term_above_threshold +1465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic glycan and lipid processing,False,no_term_above_threshold +1466,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic TM1-TM2 sensor hairpin,False,no_term_above_threshold +1467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase sugar-binding core,False,no_term_above_threshold +1468,30398,17.514874,0.6386719,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.6386719,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6338136485064357,0.14369604328620722,0.004873726185201595,0.18181818181818182,29.483815426997246,15.0,15.0,72.00603864734299,4.153748814633804e-28,ABC NBD catalytic core,True,assigned_and_evaluated +1469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transporter TM helices,False,no_term_above_threshold +1470,50869,16.07403,0.87158203,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.87158203,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,9.0,19.0,434.4850202429149,3.0844940662937045e-22,Helical ligand-sensing regulatory cores,True,assigned_too_few_test_positives +1471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Whole-chain activation in secreted PLCs,False,no_term_above_threshold +1472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Right-handed beta-helix repeats,False,no_term_above_threshold +1473,48767,16.15119,0.9946289,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9946289,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,18.0,0.0,1.0,Extracellular carbohydrate-recognition loops,True,assigned_too_few_test_positives +1474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible nucleic-acid interdomain linkers,False,no_term_above_threshold +1475,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal DNA repair modules,False,no_term_above_threshold +1476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding transferase regions,False,no_term_above_threshold +1477,87856,16.211864,0.7338867,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7338867,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5302986605140037,0.08294828786632065,0.012405848471422242,0.07142857142857142,6.686224489795918,15.0,18.0,70.57410037878789,2.613681639193851e-26,RT/RdRp palm catalytic core,True,assigned_and_evaluated +1478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity loops,False,no_term_above_threshold +1479,88058,23.777983,0.63427734,Signal,keyword,88058,Signal,0.63427734,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6296182776102586,0.13311697723267157,0.09127159946832078,,1.4584709592919405,11.0,20.0,3.9627250755287013,3.3783237560984466e-05,Surface beta-edge interaction patches,True,assigned_and_evaluated +1480,87326,19.608332,0.6171875,Coiled coil,keyword,87326,Coiled coil,0.6171875,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6336135411915917,0.13655013736979377,0.03943287549844927,0.07865168539325842,3.462850112849714,12.0,18.0,8.40501867907239,1.4878219757400116e-09,Terminal IDRs flanking coiled-coils,True,assigned_and_evaluated +1481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-active catalytic pockets,False,no_term_above_threshold +1482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-adjacent hydrophobic helix motif,False,no_term_above_threshold +1483,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic interhelical loop activation,False,no_term_above_threshold +1484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MCP methyl-accepting coiled-coil,False,no_term_above_threshold +1485,37468,19.958593,0.9741211,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.91845703,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,2.0,20.0,13.737557603686636,0.015711742271564955,Active-site and metal micro-motifs,True,assigned_too_few_test_positives +1486,64003,21.478418,0.9975586,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.7636719,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,19.0,19.0,130.4617067833698,3.819237356487831e-40,C2H2 zinc finger recognition helix,True,assigned_and_evaluated +1487,81799,18.804567,0.85498047,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6381836,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,10.0,16.0,361.7779126213592,3.5419734069741575e-24,Conserved ATPase C-terminal subdomains,True,assigned_too_few_test_positives +1488,55053,21.481924,0.9848633,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9848633,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,13.0,552.0462962962963,5.9319613712133276e-36,Acyl/amide biosynthetic loop motifs,True,assigned_too_few_test_positives +1489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helices and tails,False,no_term_above_threshold +1490,45804,15.859908,0.97753906,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.8486328,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,6.0,20.0,82.80694444444444,1.6521131030355185e-10,Transmembrane helix-loop junctions,True,assigned_too_few_test_positives +1491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal membrane-anchoring disordered tails,False,no_term_above_threshold +1492,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transactivation-like IDRs,False,no_term_above_threshold +1493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,tRNA-splicing endonuclease detector,False,no_term_above_threshold +1494,59229,17.44602,0.83203125,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.83203125,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8871394651823596,0.06429382108541945,0.0101905183872397,,6.309180616947465,0.0,18.0,0.0,1.0,Surface amphipathic helix-cap motifs,True,assigned_and_evaluated +1495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal subdomain and extension,False,no_term_above_threshold +1496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CtpA/Prc PDZ-proximal beta-strand motif,False,no_term_above_threshold +1497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature folded domain functional surfaces,False,no_term_above_threshold +1498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helical interface motifs,False,no_term_above_threshold +1499,87852,16.899973,0.9296875,Nucleosome core,keyword,24789,nucleosome,0.91503906,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,1.0,18.0,34.86608187134503,0.04720872399805875,Terminal targeting and basic tails,True,assigned_too_few_test_positives +1500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal OMP beta-barrel regions,False,no_term_above_threshold +1501,87914,16.24088,0.65722656,Phosphoprotein,keyword,87857,Nucleus,0.6567383,957,keywords,Phosphoprotein,keyword:keywords:Phosphoprotein,84.0,2257.0,0.7252700896281201,0.09949485661512214,0.03721754541426672,,2.673332040242032,14.0,18.0,4.739079089309033,3.216211055331102e-08,Acidic phosphosite-rich IDRs,True,assigned_and_evaluated +1502,82597,21.490921,0.91064453,Tetratricopeptide repeat domain,gene3d,88009,Repeat,0.67089844,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9143185246126423,0.17456330692847946,0.0057598582188746125,0.15384615384615385,30.306875672121393,0.0,15.0,0.0,1.0,Noncatalytic Rossmann scaffold residues,True,assigned_and_evaluated +1503,36104,15.641037,0.98046875,Rho GTPase-activating protein domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.890625,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Noncatalytic RT core motifs,True,assigned_too_few_test_positives +1504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane hairpin anchors,False,no_term_above_threshold +1505,49116,23.017618,0.92578125,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.92578125,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9971580817051511,0.3175124875124875,0.002215330084182543,,143.32513686313686,2.0,19.0,9.161890126776795,0.03337694297111758,TPR cofactor Phe-centered motif,True,assigned_and_evaluated +1506,37071,17.70007,0.8144531,Homeodomain,interpro,43624,Homedomain-like superfamily,0.7084961,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,19.0,0.0,1.0,ELM2 co-repressor scaffold,True,assigned_too_few_test_positives +1507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FGAM synthase FNEELGAV motif,False,no_term_above_threshold +1508,39971,18.246275,0.82666016,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.80810547,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,14.0,0.0,1.0,Catalytic transmembrane helices,True,assigned_too_few_test_positives +1509,87108,16.69937,0.6430664,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.63720703,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.7179715302491103,0.07216004586223165,0.003987594151528578,,18.096135945672984,0.0,17.0,0.0,1.0,Envelope transferase TM helices,True,assigned_and_evaluated +1510,36104,17.154686,0.8808594,Rho GTPase-activating protein domain,interpro,46274,Ribonuclease H-like superfamily,0.7348633,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,DEDDh/DEDDy 3'-5' exonuclease,True,assigned_too_few_test_positives +1511,45551,16.185078,0.97216797,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.97216797,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,18.0,0.0,1.0,Carbohydrate enzyme core helix,True,assigned_too_few_test_positives +1512,64507,34.734478,0.9951172,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9951172,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997034400948991,0.9191718775052109,0.003987594151528578,1.0,230.50788083658458,17.0,18.0,155.97983995075407,1.4177070089810998e-36,Ankyrin repeat helix-loop turn,True,assigned_and_evaluated +1513,37071,18.702196,0.9453125,Homeodomain,interpro,87384,DNA-binding,0.61328125,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,18.0,0.0,1.0,Flanking auxiliary chromatin contact segments,True,assigned_too_few_test_positives +1514,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tandem-repeat consensus positions,False,no_term_above_threshold +1515,87697,18.413265,0.8256836,Knottin,keyword,88009,Repeat,0.6953125,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9137939007190584,0.08721847226072185,0.017279574656623838,,5.047489535703826,0.0,18.0,0.0,1.0,Tandem repeat periodicity detector,True,assigned_and_evaluated +1516,38317,16.950747,0.9067383,Pentatricopeptide repeat,interpro,87326,Coiled coil,0.6904297,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9016190476190477,0.048000874654541864,0.0031014621178555605,,15.476853442185854,0.0,20.0,0.0,1.0,Coiled-coil heptad face,True,assigned_and_evaluated +1517,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue active-site capping loop,False,no_term_above_threshold +1518,59229,28.980516,0.98046875,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98046875,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9220544159433264,0.623926124653854,0.0101905183872397,0.7391304347826086,61.226141884510795,9.0,18.0,53.13814616755793,5.595273040456329e-14,Rossmann helix–loop–β cofactor-edge connector,True,assigned_and_evaluated +1519,38873,20.827269,0.8769531,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77001953,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8855239786856128,0.05776188163677348,0.002215330084182543,,26.073713370839553,0.0,15.0,0.0,1.0,Substrate phosphate-binding loop-helix,True,assigned_and_evaluated +1520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar helix-start motif,False,no_term_above_threshold +1521,85672,19.089352,0.62158203,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.62158203,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6040572314773125,0.08281084133777569,0.01595037660611431,0.05555555555555555,5.191779691648882,16.0,17.0,37.66032372680616,1.0625257265577e-24,SF1/SF2 helicase C-terminal peak,True,assigned_and_evaluated +1522,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RGS/BAR helical scaffolds,False,no_term_above_threshold +1523,41154,16.202513,0.87158203,Phosphopantetheine attachment site,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.69921875,29,ip,IPR006162,interpro:ip:IPR006162,8.0,2257.0,0.8708314806580703,0.2121338969499162,0.003544528134692069,,59.84827567699511,1.0,16.0,47.773237179487175,0.034893368849609356,N-terminal motif I SAM-binding loop,True,assigned_and_evaluated +1524,59229,38.030514,0.86621094,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.86621094,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8454322525397999,0.6114484715518216,0.0101905183872397,0.6521739130434783,60.001704360541794,12.0,12.0,106.27629233511585,1.2791368554001287e-24,Noncatalytic substrate recognition regions,True,assigned_and_evaluated +1525,82107,16.672558,0.6411133,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.6333008,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,15.0,0.0,1.0,Non-catalytic N-lobe α/β segments,True,assigned_too_few_test_positives +1526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine synthase core helix-loop,False,no_term_above_threshold +1527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter coupling helices,False,no_term_above_threshold +1528,38317,17.086058,0.8457031,Pentatricopeptide repeat,interpro,87326,Coiled coil,0.61865234,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7753015873015873,0.05844823999927283,0.0031014621178555605,,18.845382525479824,0.0,20.0,0.0,1.0,Coiled-coil heptad stripe,True,assigned_and_evaluated +1529,45324,17.024948,0.9980469,Pectin lyase fold/virulence factor,interpro,64507,Ankyrin repeat-containing domain superfamily,0.81640625,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9982238010657194,0.40349206349206346,0.002215330084182543,1.0,182.13631746031746,17.0,18.0,516.5937818552497,3.251667628033392e-45,PbH1 beta-helix activation,True,assigned_and_evaluated +1530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Buried β-strand core activations,False,no_term_above_threshold +1531,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic low-complexity linkers,False,no_term_above_threshold +1532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Q/N-rich prion-like activation domains,False,no_term_above_threshold +1533,46078,19.691877,0.9790039,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9790039,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,16.0,17.0,123.05675954592363,7.926133915404897e-33,HEAT repeat hydrophobic core residues,True,assigned_too_few_test_positives +1534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial cytoplasmic pre-TM linkers,False,no_term_above_threshold +1535,85649,28.419819,0.9736328,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9707031,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9514616013389903,0.6895731844678766,0.0101905183872397,0.9130434782608695,67.66811640626076,6.0,17.0,39.04027065371603,1.2217930930349791e-08,Adenosyl cofactor acidic anchors,True,assigned_and_evaluated +1536,59229,31.260681,0.97216797,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97216797,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8613327624459928,0.5996725801117706,0.0101905183872397,0.7391304347826086,58.84613101357679,19.0,19.0,106.27629233511585,1.6359638213673626e-38,MTase post-motif-I loop,True,assigned_and_evaluated +1537,36104,17.000862,0.66015625,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.66015625,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,OEP periplasmic coiled coil,True,assigned_too_few_test_positives +1538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF diguanylate cyclase core,False,no_term_above_threshold +1539,87697,21.736769,0.89941406,Knottin,keyword,87413,Disulfide bond,0.6533203,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.955145545767728,0.15277256065492206,0.017279574656623838,,8.84122229226049,0.0,17.0,0.0,1.0,xTGPx/DPT loop-turn motif,True,assigned_and_evaluated +1540,50338,16.937145,0.77197266,"GPCR, rhodopsin-like, 7TM",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.60546875,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,SF2 helicase hinge region,True,assigned_too_few_test_positives +1541,69990,16.168455,0.93115234,DNA/RNA polymerase superfamily,interpro,87856,Nucleotidyltransferase,0.76220703,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.774063492063492,0.40160749118594546,0.0031014621178555605,0.42857142857142855,129.489729658097,12.0,12.0,262.647577092511,2.5294230216054737e-29,Polymerase palm active site,True,assigned_and_evaluated +1542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP enzyme internal-region activation,False,no_term_above_threshold +1543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter TM1 entry,False,no_term_above_threshold +1544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich disordered linkers,False,no_term_above_threshold +1545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane interfacial helix anchors,False,no_term_above_threshold +1546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic N-terminal leader helices,False,no_term_above_threshold +1547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic helical linkers,False,no_term_above_threshold +1548,50806,18.750965,0.97509766,"Homeobox, conserved site",interpro,87384,DNA-binding,0.6850586,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,HTH DNA-binding helices,True,assigned_too_few_test_positives +1549,36010,19.365173,0.9980469,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.92822266,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,18.0,18.0,509.58119658119665,2.3458872067348707e-48,AB-hydrolase cap helix motif,True,assigned_too_few_test_positives +1550,48883,16.996843,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,16.0,16.0,480.8145161290322,6.075488456631373e-43,AAT-fold PLP mid-loop,True,assigned_too_few_test_positives +1551,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"ABC NBD conserved residue, interfaces",False,no_term_above_threshold +1552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity amphipathic helices,False,no_term_above_threshold +1553,88153,16.190731,0.62597656,Transferase,keyword,87601,Hydrolase,0.62353516,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.6770601598918333,0.1764334925957916,0.052724856003544526,0.01680672268907563,3.3463058217537958,9.0,14.0,7.293584341443523,8.214522237520544e-07,Active-site aromatic/polar motif,True,assigned_and_evaluated +1554,36535,16.040937,0.86816406,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8491211,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9485313751668892,0.8108002088739793,0.004430660168365086,0.8,182.99760714285713,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Eukaryotic protein kinase domain,True,assigned_and_evaluated +1555,87276,36.381844,0.6503906,Cell membrane,keyword,88161,Transmembrane helix,0.64697266,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7513008782417687,0.4676803515186967,0.11120957022596367,0.545816733067729,4.2053966270027825,4.0,16.0,2.051369391687311,0.1948206335193514,Charged juxtamembrane loops,True,assigned_and_evaluated +1556,52236,15.735979,0.99121094,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98828125,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,11.0,17.0,144.48799294998898,3.9262665954059355e-22,Conserved TPR helix cores,True,assigned_too_few_test_positives +1557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic FG-repeat interaction IDRs,False,no_term_above_threshold +1558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electropositive cofactor-binding patches,False,no_term_above_threshold +1559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix-linker junctions,False,no_term_above_threshold +1560,85672,37.053032,0.9560547,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.95410156,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9230264145279904,0.6514528221298224,0.01595037660611431,0.75,40.8424727651947,11.0,12.0,36.679586129753915,6.526843028237956e-17,Motif-flanking nucleotide switch loops,True,assigned_and_evaluated +1561,36104,16.619638,0.9995117,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9995117,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Amphipathic helical assembly domains,True,assigned_too_few_test_positives +1562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal periplasmic sensor region,False,no_term_above_threshold +1563,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Endomembrane luminal disordered regions,False,no_term_above_threshold +1564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2 domains and flanking linkers,False,no_term_above_threshold +1565,42054,17.665348,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,14.0,677.5113636363636,6.4988362365136876e-40,Radical SAM HPT loop,True,assigned_too_few_test_positives +1566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic cofactor pocket loops,False,no_term_above_threshold +1567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ubiquitin/UBL disordered linkers,False,no_term_above_threshold +1568,37894,27.191715,0.94140625,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.94140625,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR catalytic helix near YXXXK,True,assigned_too_few_test_positives +1569,82029,28.223454,1.0,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS helix-start capping motifs,True,assigned_too_few_test_positives +1570,27013,16.287544,0.67871094,side of membrane,go_cc,87735,Lipoprotein,0.6113281,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.494002665482008,0.002658396101019052,0.002658396101019052,,1.0,0.0,18.0,0.0,1.0,Periplasmic low-complexity linkers,True,assigned_and_evaluated +1571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeated transmembrane helix-loop interfaces,False,no_term_above_threshold +1572,38317,23.297049,0.97216797,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.97216797,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9973968253968254,0.6038723181580323,0.0031014621178555605,0.8571428571428571,194.70568886895413,10.0,19.0,202.44821731748726,2.5613317359954077e-21,Organelle RNA gene-expression proteins,True,assigned_and_evaluated +1573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calpain Domain III activation,False,no_term_above_threshold +1574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site nucleophile and cofactor loops,False,no_term_above_threshold +1575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-scale catalytic and interaction surfaces,False,no_term_above_threshold +1576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Jelly-roll capsid with basic arms,False,no_term_above_threshold +1577,64599,16.17406,0.93115234,Chaperone J-domain superfamily,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.8588867,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,0.0,18.0,0.0,1.0,Short beta-strand/turn motif,True,assigned_too_few_test_positives +1578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cupredoxin beta-strand motif,False,no_term_above_threshold +1579,88058,21.995308,0.62646484,Signal,keyword,88058,Signal,0.62646484,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6299295157938586,0.10918789463892481,0.09127159946832078,,1.1962964961167635,2.0,20.0,0.7204954682779456,1.0,N-terminal amphipathic/hydrophobic helices,True,assigned_and_evaluated +1580,63951,22.625,0.9663086,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.95996094,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9956010280743376,0.3178451178451178,0.003987594151528578,,79.70849233071455,1.0,17.0,9.478696343402225,0.1624961879479745,Extracellular beta-sandwich edge loops,True,assigned_and_evaluated +1581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sugar-binding groove loops,False,no_term_above_threshold +1582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme C-terminal beta-strand cap/linker,False,no_term_above_threshold +1583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible Gly/Ser-rich junction loops,False,no_term_above_threshold +1584,87857,24.000673,0.6298828,Nucleus,keyword,87857,Nucleus,0.6298828,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.5806804622665541,0.12541915028574677,0.06247230837394772,0.028368794326241134,2.0075959020917056,18.0,18.0,6.059044715447154,1.8840058353317345e-14,Acidic serine-rich disordered tails,True,assigned_and_evaluated +1585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adaptor anion-binding interfaces,False,no_term_above_threshold +1586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered coiled-coil tails,False,no_term_above_threshold +1587,25169,15.711604,0.9428711,pilus,go_cc,25169,pilus,0.9428711,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9968028419182948,0.7849999999999999,0.002215330084182543,0.8,354.349,9.0,17.0,292.2598039215686,9.507650930809166e-21,Beta-edge interaction loops,True,assigned_and_evaluated +1588,82029,17.801725,0.87890625,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7211914,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,19.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +1589,36272,15.951786,0.94921875,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.94921875,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,16.0,0.0,1.0,Cationic anion-binding catalytic patch,True,assigned_too_few_test_positives +1590,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal interfacial segments,False,no_term_above_threshold +1591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-rich coiled-coil scaffolds,False,no_term_above_threshold +1592,27733,18.061388,0.8149414,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,87384,DNA-binding,0.60058594,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8486434938305242,0.2588593693285882,0.0101905183872397,0.30434782608695654,25.40198245976624,10.0,19.0,28.26979611190137,8.447794298340832e-13,Disordered TF regulatory flanks,True,assigned_and_evaluated +1593,52940,15.690811,0.8671875,"AMP-binding, conserved site",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.8354492,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,13.0,0.0,1.0,PGT catalytic membrane core,True,assigned_too_few_test_positives +1594,87149,22.847895,0.74072266,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.74072266,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.81952989809652,0.10350586601720838,0.012405848471422242,,8.343312128601404,0.0,17.0,0.0,1.0,"Disordered tails, linkers, propeptides",True,assigned_and_evaluated +1595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chain-wide activation in SerK/Srx/ParB,False,no_term_above_threshold +1596,49116,16.285713,0.77783203,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.77783203,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.7903197158081705,0.0801362936367758,0.002215330084182543,,36.1735229476406,1.0,20.0,4.351897810218978,0.32552345429018376,Extended alpha-helical scaffolds,True,assigned_and_evaluated +1597,37640,19.068531,0.9926758,EF-hand domain,interpro,88263,Zinc-finger,0.7397461,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,6.0,17.0,105.74224061483892,3.295822316334973e-11,Ca2+-binding loop residues,True,assigned_too_few_test_positives +1598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil interface helices,False,no_term_above_threshold +1599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic N-terminal IDRs and PA14,False,no_term_above_threshold +1600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-proximal loops/hinges,False,no_term_above_threshold +1601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helix-capping junction motif,False,no_term_above_threshold +1602,52236,16.128946,0.8359375,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8330078,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,10.0,16.0,139.56226591760299,5.554995164624011e-20,Acidic–aromatic helix–turn motif,True,assigned_too_few_test_positives +1603,87390,16.465279,0.7753906,Defensin,keyword,87390,Defensin,0.7753906,37,keywords,Defensin,keyword:keywords:Defensin,,,,,,,,0.0,15.0,0.0,1.0,Cationic N-terminal polyanion-binding patches,True,assigned_too_few_test_positives +1604,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged N-terminal helical recognition module,False,no_term_above_threshold +1605,87326,36.65541,0.74121094,Coiled coil,keyword,87326,Coiled coil,0.74121094,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7922151623201625,0.35339831223702867,0.03943287549844927,0.29213483146067415,8.962022367628919,18.0,20.0,11.346775216747726,6.031390779229954e-18,Long coiled-coil scaffolds,True,assigned_and_evaluated +1606,43624,16.099075,0.7890625,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.7890625,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8472640562248995,0.02324398572340467,0.007089056269384138,,3.2788547361077716,0.0,14.0,0.0,1.0,Acidic glycine-rich catalytic loops,True,assigned_and_evaluated +1607,36668,18.651054,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.98583984,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,18.0,18.0,532.3303571428571,1.2239400872533205e-48,Adenylate-forming ANL superfamily,True,assigned_too_few_test_positives +1608,88058,92.06251,0.92041016,Signal,keyword,88058,Signal,0.92041016,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9304968450152187,0.7334979699260396,0.09127159946832078,0.8932038834951457,8.036431641374133,20.0,20.0,7.204954682779456,1.6966660215964757e-17,Gram-negative signal peptide h-region,True,assigned_and_evaluated +1609,58239,28.196922,0.6699219,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6699219,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7196774921064502,0.3372035479901142,0.017722640673460344,0.3,19.026710195342197,16.0,16.0,35.851473241130485,3.796994109691943e-25,UvrD-like SF1 helicase motor,True,assigned_and_evaluated +1610,37341,22.184784,0.9980469,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99072266,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999667829264242,0.9974457215836523,0.011962782454585734,1.0,83.37907383756678,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 blade strand starts,True,assigned_and_evaluated +1611,66234,16.131905,0.81884766,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.81884766,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,18.0,19.0,224.13909774436087,1.96913572322473e-41,Ub/Ubl isopeptidase gating core,True,assigned_too_few_test_positives +1612,31094,18.003498,0.9555664,phosphopantetheine binding,go_mf,31094,phosphopantetheine binding,0.9555664,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9445927903871829,0.29065799728439934,0.004430660168365086,,65.60150998708893,0.0,13.0,0.0,1.0,Domain-wide helix-centric activation,True,assigned_and_evaluated +1613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-lining beta-strands,False,no_term_above_threshold +1614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-B glycosyltransferase catalytic core,False,no_term_above_threshold +1615,30856,16.233074,0.8227539,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.7192383,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.8172291296625221,0.04101655806091679,0.002215330084182543,,18.514874308697838,0.0,19.0,0.0,1.0,Juxtamembrane TM helix caps,True,assigned_and_evaluated +1616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap boundary residues,False,no_term_above_threshold +1617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar-acidic disordered tails/linkers,False,no_term_above_threshold +1618,37020,16.895046,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,17.0,816.7260273972603,3.4794486095487155e-49,C-terminal donor-binding capping helix,True,assigned_too_few_test_positives +1619,88164,16.542212,0.7270508,Transposition,keyword,88163,Transposable element,0.6376953,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.7906305506216696,0.048658707284509134,0.002215330084182543,,21.964540468227426,1.0,16.0,45.44283536585366,0.03661939367029113,Amphipathic helical interface elements,True,assigned_and_evaluated +1620,36886,16.196007,0.9248047,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.70996094,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8942029791018231,0.017385393841702724,0.003544528134692069,,4.904854237590381,0.0,15.0,0.0,1.0,Hydrophobic beta-strand scaffolds,True,assigned_and_evaluated +1621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic acyl-thioester loop,False,no_term_above_threshold +1622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged noncatalytic interaction regions,False,no_term_above_threshold +1623,87970,17.885078,0.8305664,Protein phosphatase,keyword,87970,Protein phosphatase,0.8305664,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,12.0,14.0,246.87784679089023,6.799458477128757e-28,PTP/DSP catalytic core scaffold,True,assigned_too_few_test_positives +1624,10369,19.391283,0.79248047,DNA integration,go_bp,46274,Ribonuclease H-like superfamily,0.7236328,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,11.0,15.0,401.11987767584094,2.0360311693114148e-27,C-terminal polyanion-binding patch,True,assigned_too_few_test_positives +1625,88160,17.66264,0.828125,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.828125,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,15.0,18.0,241.18527508090614,2.7942157140884263e-34,Extracellular beta-barrel loops,True,assigned_too_few_test_positives +1626,88263,38.14327,0.93603516,Zinc-finger,keyword,29166,zinc ion binding,0.9067383,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.965023435796817,0.17049290471429412,0.014621178555604785,,11.660681392126117,0.0,14.0,0.0,1.0,Core-flanking polybasic SLiMs,True,assigned_and_evaluated +1627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-dependent DD-peptidase-like catalytic site,False,no_term_above_threshold +1628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-to-TM helix boundaries,False,no_term_above_threshold +1629,82029,16.910522,0.9248047,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8310547,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix-loop interfaces,True,assigned_too_few_test_positives +1630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader/initial helix,False,no_term_above_threshold +1631,29104,21.01532,0.7314453,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.71777344,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,18.0,0.0,1.0,TM-loop-TM interfacial motif,True,assigned_too_few_test_positives +1632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MukF/TerS leucine-zipper coiled-coil,False,no_term_above_threshold +1633,83032,17.116524,0.9003906,SH3 Domains,gene3d,83032,SH3 Domains,0.9003906,34,gene3d,2.30.30.40,gene3d:gene3d:2.30.30.40,6.0,2257.0,0.9994817118317785,0.8134920634920634,0.002658396101019052,1.0,306.0085978835978,12.0,19.0,185.49442571947108,2.632398284193942e-25,SH3/SH3b domain N-terminus,True,assigned_and_evaluated +1634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic site motifs,False,no_term_above_threshold +1635,85682,15.659989,0.8588867,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7993164,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9371953405017922,0.08421577932985425,0.011076650420912717,,7.603000557899241,0.0,14.0,0.0,1.0,Glycine-rich flexible active-site loops,True,assigned_and_evaluated +1636,49116,27.36036,0.9692383,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9692383,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,19.0,19.0,87.03795620437957,6.605101239071875e-37,HEAT repeat A-helix preference,True,assigned_and_evaluated +1637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix cores,False,no_term_above_threshold +1638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PI-PLC Y-box/C2 hotspot,False,no_term_above_threshold +1639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed beta-edge binding loops,False,no_term_above_threshold +1640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal N-glycosylated ectodomains,False,no_term_above_threshold +1641,31094,19.173271,0.99853516,phosphopantetheine binding,go_mf,69093,"ANL, N-terminal domain",0.8955078,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9993769470404984,0.8400324675324675,0.004430660168365086,1.0,189.59532792207793,10.0,11.0,645.2489177489177,6.580567677100469e-28,NRPS/ANL A-PCP pairs,True,assigned_and_evaluated +1642,48880,16.634626,0.95996094,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.95996094,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,17.0,17.0,484.7235772357723,1.7310182502290982e-45,Type I PLP N-terminal helix/loop,True,assigned_too_few_test_positives +1643,42054,15.69234,1.0,Radical SAM,interpro,87681,Iron-sulfur,0.7348633,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,14.0,677.5113636363636,6.4988362365136876e-40,Radical SAM CxxxCxxC loop,True,assigned_too_few_test_positives +1644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-periplasm boundary motifs,False,no_term_above_threshold +1645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking surface loop,False,no_term_above_threshold +1646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface hairpin gate,False,no_term_above_threshold +1647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic TF DNA-binding domains,False,no_term_above_threshold +1648,46079,15.680769,0.8027344,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8027344,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.870012340600576,0.05786816965907488,0.0057598582188746125,,10.046804532348615,0.0,16.0,0.0,1.0,Amphipathic helical interaction motifs,True,assigned_and_evaluated +1649,32555,17.30772,0.7763672,"proton-transporting ATP synthase activity, rotational mechanism",go_mf,32555,"proton-transporting ATP synthase activity, rotational mechanism",0.7763672,70,go,GO:0046933,go_mf:go:GO:0046933,23.0,2257.0,0.9768401385699272,0.7197487700426006,0.0101905183872397,0.9565217391304348,70.62925973852823,0.0,16.0,0.0,1.0,Charged helical interaction surfaces,True,assigned_and_evaluated +1650,64585,17.73044,0.95947266,"Zinc finger, CCCH-type superfamily",interpro,88263,Zinc-finger,0.6953125,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,17.0,0.0,1.0,Cytochrome c CXXCH motif,True,assigned_too_few_test_positives +1651,64146,18.631842,0.62353516,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.62353516,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.5122078308768796,0.01447656673066509,0.007975188303057155,,1.8152006172839505,10.0,14.0,47.74263292761051,1.2006377669837232e-15,Leucine-rich coupling helices,True,assigned_and_evaluated +1652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane loop redox/metal interfaces,False,no_term_above_threshold +1653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavodoxin-like FMN-binding domain,False,no_term_above_threshold +1654,85682,17.716743,0.8041992,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8041992,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.974516129032258,0.2006129138949853,0.011076650420912717,,18.111333866439274,1.0,17.0,6.015639188780143,0.24451580700257655,Cofactor pocket bordering loop,True,assigned_and_evaluated +1655,85649,18.175537,0.8803711,Vaccinia Virus protein VP39,gene3d,88153,Transferase,0.69921875,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9065528784399206,0.3653080580938832,0.0101905183872397,0.43478260869565216,35.847838570343235,0.0,16.0,0.0,1.0,Loop-helix capping motif,True,assigned_and_evaluated +1656,25169,16.135805,0.77490234,pilus,go_cc,25169,pilus,0.77490234,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.6813943161634103,0.01885300757431905,0.002215330084182543,,8.51024761904762,4.0,20.0,110.40925925925926,9.553619198311984e-08,Gram-positive sortase-anchored adhesins,True,assigned_and_evaluated +1657,43583,16.920794,0.9301758,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9301758,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,19.0,19.0,416.9300699300699,3.94634834107562e-49,Gly-centered trypsin-fold loop–β–loop motif,True,assigned_and_evaluated +1658,37097,16.90146,0.78515625,Cro/C1-type helix-turn-helix domain,interpro,37097,Cro/C1-type helix-turn-helix domain,0.78515625,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,7.0,16.0,246.07724056603772,1.2267786314342004e-15,Cro/LexA N-terminal HTH hairpins,True,assigned_too_few_test_positives +1659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic helices and loops,False,no_term_above_threshold +1660,24983,21.478182,0.71972656,mitochondrial inner membrane,go_cc,87785,Mitochondrion,0.6464844,179,go,GO:0005743,go_cc:go:GO:0005743,20.0,2257.0,0.6879749664729549,0.303679263064509,0.008861320336730172,0.4,34.27020483682984,15.0,15.0,59.98088531187122,6.248092279587431e-27,Mature organelle protein cores,True,assigned_and_evaluated +1661,63951,16.204077,0.7519531,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.6879883,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.829305061289047,0.1990143832356947,0.003987594151528578,,49.908384773662554,0.0,13.0,0.0,1.0,Extracellular cadherin EC1 motifs,True,assigned_and_evaluated +1662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,JAMM/MPN deubiquitinase module,False,no_term_above_threshold +1663,52236,24.851534,0.99609375,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99560547,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,15.0,223.29962546816478,2.087522942442783e-35,TPR/SEL1 N-cap detector,True,assigned_too_few_test_positives +1664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Defense signaling and hydrolases,False,no_term_above_threshold +1665,49116,25.793219,0.9658203,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9658203,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9979573712255773,0.46691729323308273,0.002215330084182543,0.8,210.76646616541356,16.0,16.0,87.03795620437957,3.1459123761526603e-31,HEAT/ARM N-terminal cap,True,assigned_and_evaluated +1666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic transmembrane helix bundles,False,no_term_above_threshold +1667,36091,23.665562,0.9472656,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.8876953,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,PAS/PAC capping motif,True,assigned_too_few_test_positives +1668,87276,32.94553,0.63378906,Cell membrane,keyword,88161,Transmembrane helix,0.609375,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7312752976131367,0.41060489351311535,0.11120957022596367,0.50199203187251,3.692172289478491,9.0,20.0,3.6924649050371596,0.0005015653316458726,Loop-to-TM helix junction,True,assigned_and_evaluated +1669,38890,20.656591,0.93603516,HNH nuclease,interpro,38890,HNH nuclease,0.93603516,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,0.0,13.0,0.0,1.0,U-box/RING E3 catalytic module,True,assigned_too_few_test_positives +1670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible capsid assembly loops,False,no_term_above_threshold +1671,46932,28.981808,0.95458984,Zinc finger C2H2-type,interpro,88263,Zinc-finger,0.77441406,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9982198486871384,0.8803418803418803,0.004430660168365086,0.9,198.6931623931624,17.0,17.0,108.20508166969147,1.0262878880954455e-34,C2H2 array linker activation,True,assigned_and_evaluated +1672,47529,15.609438,0.7246094,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7246094,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.795933734939759,0.12646710552613846,0.007089056269384138,0.125,17.839766073280906,1.0,16.0,4.833090142671855,0.29742221945743563,Non-transmembrane beta-rich domains,True,assigned_and_evaluated +1673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory interaction regions,False,no_term_above_threshold +1674,87882,21.30619,0.68652344,Palmitate,keyword,87882,Palmitate,0.68652344,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.5730786317192359,0.008388169590355384,0.002658396101019052,,3.1553497942386834,7.0,18.0,25.906083178150215,9.383233206135313e-09,N-terminal targeting signals,True,assigned_and_evaluated +1675,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small hydrophobic stretch detector,False,no_term_above_threshold +1676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal cofactor binding effector domains,False,no_term_above_threshold +1677,85672,21.075596,0.7998047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7939453,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8641065085797188,0.08474300855554663,0.01595037660611431,0.027777777777777776,5.312915841940799,0.0,18.0,0.0,1.0,β→α junction hinge residues,True,assigned_and_evaluated +1678,37640,24.612638,0.9975586,EF-hand domain,interpro,46081,EF-hand domain pair,0.9916992,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,17.0,18.0,282.9584031267448,6.824310871704072e-41,Amphipathic Ca2+-sensor helices,True,assigned_too_few_test_positives +1679,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DXPS C-terminal glycine-rich loop,False,no_term_above_threshold +1680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface helices,False,no_term_above_threshold +1681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal accessory subdomains,False,no_term_above_threshold +1682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding cradle subdomain,False,no_term_above_threshold +1683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass TM helix bundle,False,no_term_above_threshold +1684,85712,17.66201,0.8979492,3.40.630.30,gene3d,49116,Armadillo-type fold,0.72509766,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,19.0,0.0,1.0,Tat twin-arginine signal peptide,True,assigned_too_few_test_positives +1685,85712,16.58299,0.88378906,3.40.630.30,gene3d,85712,3.40.630.30,0.88378906,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,20.0,0.0,1.0,Hydrophobic helical interaction core,True,assigned_too_few_test_positives +1686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic N-termini of divalent-cation channels/transporters,False,no_term_above_threshold +1687,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-adjacent charged low-complexity IDRs,False,no_term_above_threshold +1688,38317,18.758873,0.8701172,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8701172,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6867936507936508,0.005668586356196949,0.0031014621178555605,,1.8277142008480736,0.0,20.0,0.0,1.0,Small protein interaction segment,True,assigned_and_evaluated +1689,64058,16.62491,0.87060547,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77734375,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9508630023565378,0.06593739356782503,0.006202924235711121,,10.63004980589865,0.0,15.0,0.0,1.0,Cofactor-binding signature loops,True,assigned_and_evaluated +1690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter pore-lining transmembrane helices,False,no_term_above_threshold +1691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBS repeat core motif,False,no_term_above_threshold +1692,64058,28.899462,0.96533203,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9433594,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9585376727596968,0.5931014978106066,0.006202924235711121,0.7857142857142857,95.61643432560993,11.0,12.0,104.49824729126831,6.945102968160169e-22,Rossmann aromatic pocket residues,True,assigned_and_evaluated +1693,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide enzyme peripheral interaction regions,False,no_term_above_threshold +1694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic–acidic surface gate loops,False,no_term_above_threshold +1695,63960,19.925753,0.6748047,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.6748047,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,14.0,179.74791280148423,7.137898300063296e-29,Helix adjacent to FAD loop,True,assigned_too_few_test_positives +1696,81540,15.641901,0.89697266,"Tetracycline Repressor, domain 2",gene3d,27918,DNA-binding transcription factor activity,0.63720703,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,0.0,19.0,0.0,1.0,C-terminal ligand-binding domain,True,assigned_too_few_test_positives +1697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal motif tethers,False,no_term_above_threshold +1698,85664,18.609774,0.9165039,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9165039,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,19.0,0.0,1.0,TetR HTH alpha1 hydrophobic anchor,True,assigned_too_few_test_positives +1699,48883,19.694529,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,Aminotransferase-like PLP catalytic core,True,assigned_too_few_test_positives +1700,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory glyco/lipid TM–loop interface,False,no_term_above_threshold +1701,87586,20.16361,0.7597656,Host membrane,keyword,88161,Transmembrane helix,0.7392578,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.828372291210129,0.08889179600717276,0.01639344262295082,,5.422399556437538,0.0,17.0,0.0,1.0,Lipid-exposed TM helices and caps,True,assigned_and_evaluated +1702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-rich metal-binding segments,False,no_term_above_threshold +1703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic N-terminal targeting IDRs,False,no_term_above_threshold +1704,64058,16.628658,0.86376953,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.86035156,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9465639131265524,0.2920403393853665,0.006202924235711121,0.07142857142857142,47.08107471376944,4.0,11.0,41.453850165131236,3.5095413295154436e-06,PFK Arg-rich helical motif,True,assigned_and_evaluated +1705,85672,49.662243,0.9692383,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9609375,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9245897743759067,0.6338002866974186,0.01595037660611431,0.8611111111111112,39.735756863224275,16.0,16.0,40.01409395973155,6.696154575406941e-26,Post-P-loop phosphate sensor,True,assigned_and_evaluated +1706,82597,18.146288,0.86816406,Tetratricopeptide repeat domain,gene3d,88009,Repeat,0.6479492,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.8908371040723982,0.03377137215842112,0.0057598582188746125,,5.863229766273574,0.0,19.0,0.0,1.0,Amphipathic helices flanking P-loops,True,assigned_and_evaluated +1707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal mixed alpha/beta core,False,no_term_above_threshold +1708,45714,18.219576,0.9785156,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.9785156,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,14.0,14.0,298.105,7.283149953202633e-35,N-terminal acidic low-complexity IDRs,True,assigned_too_few_test_positives +1709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal translocase ATPase regions,False,no_term_above_threshold +1710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-tail assembly interfaces,False,no_term_above_threshold +1711,38317,17.763554,0.9399414,Pentatricopeptide repeat,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.86621094,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9001904761904762,0.01641887798866918,0.0031014621178555605,,5.29391537434662,0.0,18.0,0.0,1.0,Adenosine cofactor-binding microclusters,True,assigned_and_evaluated +1712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-sequence periplasmic β-strands,False,no_term_above_threshold +1713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short C-terminal non-motif segments,False,no_term_above_threshold +1714,87882,18.078972,0.61035156,Palmitate,keyword,87882,Palmitate,0.61035156,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.5738190433881238,0.08554866341751587,0.002658396101019052,0.16666666666666666,32.18055555555555,8.0,19.0,28.048691561305496,3.4090910926511096e-10,Secretory propeptides and transit peptides,True,assigned_and_evaluated +1715,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic C-terminal kinase extensions,False,no_term_above_threshold +1716,36104,19.171213,0.8774414,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8774414,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Extracellular catalytic core motifs,True,assigned_too_few_test_positives +1717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP periplasmic juxtamembrane segments,False,no_term_above_threshold +1718,49230,16.861378,0.95996094,Acyl-CoA N-acyltransferase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78222656,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,18.0,0.0,1.0,Helix-to-strand C-cap loop,True,assigned_too_few_test_positives +1719,58239,27.97496,0.64501953,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.64501953,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.5969835363103293,0.08512928146787839,0.017722640673460344,,4.803419706825038,17.0,17.0,35.851473241130485,1.1097904818074523e-26,NTP-binding switch/sensor region,True,assigned_and_evaluated +1720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered domain boundary tails,False,no_term_above_threshold +1721,37341,31.329334,0.98828125,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9550781,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9998505231689089,0.9882399129653279,0.011962782454585734,1.0,82.60953642824981,4.0,19.0,30.61412066752246,1.474271233744292e-05,Beta-propeller WD loop motif,True,assigned_and_evaluated +1722,27918,16.458412,0.76171875,DNA-binding transcription factor activity,go_mf,87384,DNA-binding,0.6982422,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.5756346366811483,0.010641788765822606,0.00930438635356668,,1.1437389164029343,0.0,19.0,0.0,1.0,S/T/Pro-rich disordered regions,True,assigned_and_evaluated +1723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic coiled-coil stalks,False,no_term_above_threshold +1724,36535,18.676394,0.96191406,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.94091797,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9398086337338672,0.8061392685484821,0.004430660168365086,0.8,181.9456329113924,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Kinase glycine-rich P-loop,True,assigned_and_evaluated +1725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed beta-strand motif,False,no_term_above_threshold +1726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping loops,False,no_term_above_threshold +1727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,3-6 residue micro-motifs,False,no_term_above_threshold +1728,85762,35.850403,0.96875,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.96484375,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,Oxidoreductase N-terminal targeting peptides,True,assigned_too_few_test_positives +1729,36104,19.740044,0.88916016,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.88916016,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Cys/Ser protease catalytic core,True,assigned_too_few_test_positives +1730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme catalytic core domains,False,no_term_above_threshold +1731,45324,23.348347,0.9975586,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9975586,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9976909413854351,0.34547619047619044,0.002215330084182543,,155.9479523809524,18.0,18.0,546.9816513761467,7.774077354345683e-49,Extracellular β-solenoid/β-helix signature,True,assigned_and_evaluated +1732,36535,21.01991,0.9165039,Protein kinase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7080078,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.892745883400089,0.24762148001902098,0.004430660168365086,,55.88816804029304,0.0,8.0,0.0,1.0,ABC NBD catalytic switch,True,assigned_and_evaluated +1733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RsmH C-terminus and GFP chromophore,False,no_term_above_threshold +1734,82029,15.622962,0.81103516,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6118164,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,14.0,0.0,1.0,TM-helix N-cap boundaries,True,assigned_too_few_test_positives +1735,47529,28.448019,0.9550781,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9550781,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9897367246764838,0.31004907220582095,0.007089056269384138,0.25,43.73629724803362,1.0,14.0,5.523531591624977,0.2644032687073552,Acidic beta-strand loop motif,True,assigned_and_evaluated +1736,36535,20.768637,0.9399414,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.93310547,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9451490876724521,0.8119815275552981,0.004430660168365086,0.8,183.26423076923078,14.0,14.0,89.79066265060241,1.3182594076727404e-27,APE-proximal activation-loop terminus,True,assigned_and_evaluated +1737,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early N-terminal domain scaffold,False,no_term_above_threshold +1738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Autotransporter passenger-translocator linker,False,no_term_above_threshold +1739,47529,17.069557,0.77734375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.77734375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7841923248549755,0.07913236542715531,0.007089056269384138,,11.162609298068096,4.0,19.0,16.27988258584204,0.00016806245289597164,Extracellular enzyme and usher cores,True,assigned_and_evaluated +1740,42054,15.811746,0.9560547,Radical SAM,interpro,87681,Iron-sulfur,0.6689453,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,13.0,15.0,587.1765151515152,3.430579151480721e-35,C-terminal Radical SAM extensions,True,assigned_too_few_test_positives +1741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecC/AddB C-terminal helicase activation,False,no_term_above_threshold +1742,88263,26.928783,0.7163086,Zinc-finger,keyword,88263,Zinc-finger,0.7163086,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.6404376498800959,0.047820100265086915,0.014621178555604785,,3.2706050393424597,8.0,18.0,11.58139083139083,2.825104347083954e-07,C-terminal Cys/His metal-binding modules,True,assigned_and_evaluated +1743,36449,15.978083,0.9277344,EamA domain,interpro,36449,EamA domain,0.9277344,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,17.0,0.0,1.0,Histidine kinase CA β-strands,True,assigned_too_few_test_positives +1744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxygen-rich ligand-binding pockets,False,no_term_above_threshold +1745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sugar nucleotide pocket hydrophobe,False,no_term_above_threshold +1746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity and biased-run detector,False,no_term_above_threshold +1747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic domains of membrane proteins,False,no_term_above_threshold +1748,87413,54.331203,0.8955078,Disulfide bond,keyword,87413,Disulfide bond,0.8955078,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9436680515041691,0.5779949703237879,0.0717766947275144,0.8641975308641975,8.052683012474008,15.0,19.0,9.337276438467724,4.926256193296598e-13,Disulfide-rich secreted proteins,True,assigned_and_evaluated +1749,64058,16.305834,0.83203125,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.82177734,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9468027514171072,0.06380492340968305,0.006202924235711121,,10.28626515254676,1.0,16.0,7.12488049713193,0.21028084137787656,Metal-coordinating phosphate-binding loops,True,assigned_and_evaluated +1750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine phosphatase helix motifs,False,no_term_above_threshold +1751,87326,37.41033,0.7807617,Coiled coil,keyword,87326,Coiled coil,0.7807617,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7861203822712384,0.1985393543666567,0.03943287549844927,0.02247191011235955,5.034868795567912,7.0,12.0,7.354391344188342,2.030462569855074e-05,Heptad coiled-coil interfaces,True,assigned_and_evaluated +1752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic transmembrane helical bundles,False,no_term_above_threshold +1753,64148,19.795166,0.66308594,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6616211,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.621466534970133,0.0521624175636255,0.008418254319893664,,6.196346128479093,9.0,19.0,42.151531814611154,5.051993952571705e-13,Phospho-regulated chromatin IDRs,True,assigned_and_evaluated +1754,85799,18.828117,0.7529297,3.60.21.10,gene3d,59218,Metallo-dependent phosphatase-like,0.7519531,32,gene3d,3.60.21.10,gene3d:gene3d:3.60.21.10,,,,,,,,0.0,13.0,0.0,1.0,Metal-dependent phosphoester hydrolases,True,assigned_too_few_test_positives +1755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Large eukaryotic scaffold subunits,False,no_term_above_threshold +1756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane interfacial helix-loop hairpins,False,no_term_above_threshold +1757,85364,19.120468,0.8154297,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8154297,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Aromatic glycine-rich SBP cleft,True,assigned_too_few_test_positives +1758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T-rich low-complexity repeats,False,no_term_above_threshold +1759,85649,24.27726,0.8330078,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.8330078,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.792456502277062,0.5471364742569303,0.0101905183872397,0.5652173913043478,53.690740104256164,13.0,13.0,110.61410018552876,7.552885156667182e-27,MTase motif IV catalytic loop,True,assigned_and_evaluated +1760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix end caps,False,no_term_above_threshold +1761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and transmembrane helices,False,no_term_above_threshold +1762,49116,24.858648,0.9760742,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9760742,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.999644760213144,0.8761904761904762,0.002215330084182543,1.0,395.51238095238097,19.0,19.0,87.03795620437957,6.605101239071875e-37,Alpha-solenoid hydrophobic core register,True,assigned_and_evaluated +1763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic-like protein kinase ATP core,False,no_term_above_threshold +1764,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended N-terminal leader helix,False,no_term_above_threshold +1765,84152,20.60519,0.98535156,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.98535156,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,20.0,20.0,562.4622641509434,6.378493525088735e-54,Acidic hydrolase active-site loops,True,assigned_too_few_test_positives +1766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal charged tails,False,no_term_above_threshold +1767,49045,17.681871,0.97314453,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.94628906,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,17.0,0.0,1.0,Beta-propeller/beta-helix loop surfaces,True,assigned_too_few_test_positives +1768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich disordered linkers,False,no_term_above_threshold +1769,85364,25.141218,0.93847656,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.93847656,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Extracellular VFT/PBP ligand clamshell,True,assigned_too_few_test_positives +1770,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-aromatic beta-strand motifs,False,no_term_above_threshold +1771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass membrane helix-bundle signature,False,no_term_above_threshold +1772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-finger/transposase accessory flanks,False,no_term_above_threshold +1773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site and domain starts,False,no_term_above_threshold +1774,50806,22.742027,0.9946289,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.93652344,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,HTH hydrophobic anchor residues,True,assigned_too_few_test_positives +1775,36776,19.292463,0.98876953,SANT/Myb domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9013672,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9623870872204946,0.037355364461508465,0.002658396101019052,,14.0518429316041,0.0,19.0,0.0,1.0,HTH helix-capping linker hinge,True,assigned_and_evaluated +1776,87857,25.523535,0.6972656,Nucleus,keyword,87857,Nucleus,0.6972656,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7421033932617412,0.18588635641586376,0.06247230837394772,,2.975500045607124,8.0,20.0,2.423617886178862,0.01806650059301445,Phosphoregulated PP1-docking IDRs,True,assigned_and_evaluated +1777,63831,21.415457,0.8129883,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8129883,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.646083222271583,0.1725039713844192,0.002658396101019052,0.16666666666666666,64.89024390243901,0.0,13.0,0.0,1.0,NB-ARC hydrophobic core motif,True,assigned_and_evaluated +1778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured cores and TM helices,False,no_term_above_threshold +1779,48883,23.189278,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,13.0,13.0,480.8145161290322,3.7255170365673266e-35,C-terminal PLP pocket loop,True,assigned_too_few_test_positives +1780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-adjacent DNA-binding surface,False,no_term_above_threshold +1781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-lactam acylation motif,False,no_term_above_threshold +1782,64058,21.148079,0.70458984,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7036133,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9208649130628623,0.5897402605775529,0.006202924235711121,0.5714285714285714,95.07455486596692,15.0,15.0,113.99808795411089,4.589611073054062e-31,Rossmann-fold cofactor-binding core,True,assigned_and_evaluated +1783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic interhelical sensor domain,False,no_term_above_threshold +1784,36449,16.461407,0.9692383,EamA domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.91845703,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,14.0,0.0,1.0,Activation segment APE/P+1 hotspot,True,assigned_too_few_test_positives +1785,87697,20.032187,0.8642578,Knottin,keyword,87413,Disulfide bond,0.62939453,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9293542345841715,0.10635578095801418,0.017279574656623838,,6.154999939031743,0.0,19.0,0.0,1.0,RlmK/L dual-motif peaks,True,assigned_and_evaluated +1786,85649,34.074177,0.80908203,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8051758,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7355688762601689,0.3500632224057396,0.0101905183872397,0.30434782608695654,34.35185621607627,13.0,13.0,110.61410018552876,7.552885156667182e-27,SAM-dependent methyltransferase catalytic core,True,assigned_and_evaluated +1787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular region downstream of VWA,False,no_term_above_threshold +1788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M17 leucine aminopeptidase motif,False,no_term_above_threshold +1789,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged nuclear low-complexity scaffolds,False,no_term_above_threshold +1790,43626,19.67438,0.91748047,Putative DNA-binding domain superfamily,interpro,43626,Putative DNA-binding domain superfamily,0.91748047,26,ip,IPR009061,interpro:ip:IPR009061,5.0,2257.0,0.9986678507992894,0.49928571428571433,0.002215330084182543,1.0,225.37757142857146,10.0,20.0,473.18253968253964,4.538245304450652e-25,N-terminal HTH recognition helix,True,assigned_and_evaluated +1791,64596,29.52999,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,12.0,12.0,614.6494845360825,8.092433897031415e-34,MBL-fold phosphodiesterase/nuclease core,True,assigned_too_few_test_positives +1792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface β-edge recognition patch,False,no_term_above_threshold +1793,45551,21.729101,0.9296875,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9296875,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,19.0,0.0,1.0,Cytochrome P450 B'-C loop,True,assigned_too_few_test_positives +1794,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil output helices,False,no_term_above_threshold +1795,63774,15.807092,0.9116211,RNA-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7504883,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,10.0,0.0,1.0,Surface alpha-helical scaffolds,True,assigned_too_few_test_positives +1796,8200,16.870914,0.703125,proteolysis,go_bp,88058,Signal,0.61816406,331,go,GO:0006508,go_bp:go:GO:0006508,24.0,2257.0,0.7286721898790866,0.041534343066072996,0.010633584404076208,,3.9059588458386143,2.0,14.0,6.885437117450051,0.05506927611991321,Secreted enzyme substrate-binding loops,True,assigned_and_evaluated +1797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mobile glycine-rich lid loops,False,no_term_above_threshold +1798,64148,36.89032,0.98779297,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9272461,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9948026903720427,0.7015398755110471,0.008418254319893664,0.6842105263157895,83.33555258044386,14.0,17.0,73.2830553116769,8.837554555530104e-25,Basic nucleic acid binding patch,True,assigned_and_evaluated +1799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase TGE/TGES dephosphorylation loop,False,no_term_above_threshold +1800,85364,18.80517,0.76123047,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.76123047,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,15.0,19.0,237.7232854864434,7.035555830604122e-34,Extracellular solute binding catalytic clefts,True,assigned_too_few_test_positives +1801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal secondary-structure regional activation,False,no_term_above_threshold +1802,36091,25.694178,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,17.0,17.0,377.3481012658228,1.0362764569171756e-43,GNAT acetyltransferase catalytic core,True,assigned_too_few_test_positives +1803,88058,26.321701,0.6635742,Signal,keyword,88058,Signal,0.6635742,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6735987181247131,0.1243024610827605,0.09127159946832078,,1.3618963818630603,6.0,20.0,2.1614864048338367,0.08048950337413811,Unknown generic feature,True,assigned_and_evaluated +1804,87149,22.458885,0.71728516,Amphibian defense peptide,keyword,87326,Coiled coil,0.65722656,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7306687816445556,0.03979188270045365,0.012405848471422242,,3.2075099733901387,0.0,17.0,0.0,1.0,Alpha helical oligomerization segments,True,assigned_and_evaluated +1805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Patatin lipase catalytic block,False,no_term_above_threshold +1806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase catalytic cores,False,no_term_above_threshold +1807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIKI TRAB metalloprotease domain,False,no_term_above_threshold +1808,59211,20.381289,0.9902344,Nucleotide-diphospho-sugar transferases,interpro,88252,WD repeat,0.9248047,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,1.0,1.0,0.011076650420912717,1.0,90.28,17.0,17.0,244.34836065573774,1.3495568203358695e-40,DxD-adjacent donor-binding motif,True,assigned_and_evaluated +1809,87326,40.928978,0.7817383,Coiled coil,keyword,87326,Coiled coil,0.7817383,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7804661262904764,0.26528955794592524,0.03943287549844927,0.23595505617977527,6.727623958246666,12.0,16.0,9.45564601395644,1.73356132038528e-10,Coiled-coil heptad register,True,assigned_and_evaluated +1810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical scaffolds flanking P-loop NTPases,False,no_term_above_threshold +1811,80926,17.114834,0.86376953,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.8540039,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.8328534210887153,0.02590407413134546,0.0057598582188746125,,4.497345793418977,1.0,17.0,5.611388235294117,0.26043635940455007,Helix boundary capping motifs,True,assigned_and_evaluated +1812,36535,21.693792,0.9663086,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.85839844,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.948931909212283,0.8793319549057254,0.004430660168365086,0.9,198.46522222222222,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase P+1 loop motif,True,assigned_and_evaluated +1813,85664,18.11628,0.90527344,Glycogen Phosphorylase B;,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7705078,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,8.0,0.0,1.0,ABC NBD hydrophobic beta-strand,True,assigned_too_few_test_positives +1814,49061,29.980947,0.984375,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.984375,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9965711722104723,0.6817154802789414,0.012405848471422242,1.0,54.95113710677038,6.0,16.0,37.07773631840796,1.546004595131078e-08,Post beta-strand propeller loops,True,assigned_and_evaluated +1815,25169,21.966824,0.8095703,pilus,go_cc,25169,pilus,0.8095703,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8975577264653641,0.48044306601683656,0.002215330084182543,0.8,216.87200000000004,0.0,14.0,0.0,1.0,Periplasmic aromatic heme/CBM motifs,True,assigned_and_evaluated +1816,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage RBP beta-strand cluster,False,no_term_above_threshold +1817,88009,28.699177,0.6640625,Repeat,keyword,88009,Repeat,0.6640625,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7490764802535747,0.22727118887043085,0.07266282676118742,,3.1277504468326978,6.0,15.0,3.546230483271376,0.007167403430301494,"CAP-C beta-strands, Zn-knuckles, stalks",True,assigned_and_evaluated +1818,85682,17.957329,0.8564453,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8564453,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.969847670250896,0.4296643451119275,0.011076650420912717,0.36,38.79009707670482,3.0,15.0,20.453173241852486,0.0006918555354913755,Conserved IlvD/EDD active-site motifs,True,assigned_and_evaluated +1819,64148,23.289341,0.76171875,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7451172,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8005620619914398,0.4445980738204169,0.008418254319893664,0.42105263157894735,52.813571190141104,13.0,19.0,60.885545954438335,2.785726983014201e-21,C-terminal regulatory effector modules,True,assigned_and_evaluated +1820,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical domain cores,False,no_term_above_threshold +1821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic inter-TM loops,False,no_term_above_threshold +1822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,B12/folate alpha/beta enzymes,False,no_term_above_threshold +1823,87276,39.658348,0.68066406,Cell membrane,keyword,88161,Transmembrane helix,0.65478516,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.79171251186679,0.5270628254110356,0.11120957022596367,0.6294820717131474,4.739365724911184,10.0,17.0,4.826751509852496,1.1570834170297088e-05,Transmembrane helix caps,True,assigned_and_evaluated +1824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site helical scaffold,False,no_term_above_threshold +1825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic terminal extensions,False,no_term_above_threshold +1826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity linkers,False,no_term_above_threshold +1827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-domain C-terminal surfaces,False,no_term_above_threshold +1828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal unstructured linkers,False,no_term_above_threshold +1829,45324,16.283728,0.80126953,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.80126953,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9992895204262877,0.6416666666666666,0.002215330084182543,1.0,289.6483333333333,4.0,19.0,115.15403186866247,7.951193872244164e-08,Extracellular beta-rich binding domains,True,assigned_and_evaluated +1830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-GTPase signaling helices,False,no_term_above_threshold +1831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphoregulated endocytic IDR scaffolds,False,no_term_above_threshold +1832,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calycin-type ligand-binding beta-barrels,False,no_term_above_threshold +1833,55054,26.158028,0.9995117,HAD superfamily,interpro,55054,HAD superfamily,0.9995117,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.9983126110124334,0.5933333333333333,0.002215330084182543,0.8,267.8306666666667,11.0,11.0,334.9494382022472,4.187587980531753e-28,Phosphoaspartyl catalytic loop,True,assigned_and_evaluated +1834,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF ligand-binding subregion,False,no_term_above_threshold +1835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha junction active loop,False,no_term_above_threshold +1836,85672,24.206322,0.66015625,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6533203,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5946583120716393,0.12174052668869448,0.01595037660611431,0.1111111111111111,7.632454687121762,16.0,17.0,37.66032372680616,1.0625257265577e-24,Pre-ATPase N-terminal accessory domains,True,assigned_and_evaluated +1837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity IDR,False,no_term_above_threshold +1838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid C-terminal scaffolds,False,no_term_above_threshold +1839,25169,16.968393,0.90966797,pilus,go_cc,25169,pilus,0.90966797,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9857904085257548,0.0813822229503736,0.002215330084182543,,36.735935439798645,0.0,19.0,0.0,1.0,Short aromatic beta-strands,True,assigned_and_evaluated +1840,87970,17.821701,0.86621094,Protein phosphatase,keyword,87970,Protein phosphatase,0.86621094,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,4.0,9.0,128.0107353730542,3.504442669720191e-08,SAC domain N-terminal subregion,True,assigned_too_few_test_positives +1841,88160,16.043558,0.8652344,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.8652344,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,OMP barrel turns and beta-signal,True,assigned_too_few_test_positives +1842,87522,24.276136,0.61865234,Glycoprotein,keyword,87522,Glycoprotein,0.61865234,1135,keywords,Glycoprotein,keyword:keywords:Glycoprotein,89.0,2257.0,0.7133561714830632,0.28089464695518673,0.03943287549844927,0.42696629213483145,7.123362001998387,18.0,19.0,9.907569309170137,1.849505275832428e-17,Cytoplasmic juxtamembrane regulatory helix,True,assigned_and_evaluated +1843,81858,20.274422,0.9511719,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.9511719,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,18.0,20.0,235.34605263157894,2.969623774720365e-41,GPCR ECL2/TM5–TM6 junction helices,True,assigned_too_few_test_positives +1844,81540,15.660318,1.0,"Tetracycline Repressor, domain 2",gene3d,27918,DNA-binding transcription factor activity,0.6098633,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,20.0,20.0,828.0694444444445,2.4307463492151184e-57,Hydrophobic C-terminal helical interfaces,True,assigned_too_few_test_positives +1845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mechanosensation and ion-homeostasis cytosolic domains,False,no_term_above_threshold +1846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich active-site loops,False,no_term_above_threshold +1847,46082,18.396578,0.97265625,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.97265625,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9967619047619047,0.45080911152339725,0.0031014621178555605,0.2857142857142857,145.3537378154725,12.0,18.0,100.62616033755275,2.992612369441007e-22,Phosphoinositide binding loop patches,True,assigned_and_evaluated +1848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rieske non-heme iron oxygenases,False,no_term_above_threshold +1849,46079,31.738377,0.8154297,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8154297,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.7206910736322502,0.1641362606526541,0.0057598582188746125,0.07692307692307693,28.49658002254156,13.0,19.0,63.739555921052634,1.5416494723284735e-21,Alpha-helical repeat scaffolds,True,assigned_and_evaluated +1850,88009,29.756424,0.7080078,Repeat,keyword,88009,Repeat,0.7080078,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7136884854276159,0.19397518384484563,0.07266282676118742,,2.6695243288891257,12.0,19.0,5.599311289375856,1.9359993500844814e-07,Acidic/Gly-rich low-complexity repeats,True,assigned_and_evaluated +1851,37341,25.051138,0.9975586,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9975586,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999086530476665,0.9912987671361257,0.011962782454585734,1.0,82.86523397874947,18.0,19.0,137.76354300385108,1.0024362880238542e-37,Canonical WD40 beta-propeller blades,True,assigned_and_evaluated +1852,59224,16.86195,0.90722656,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8486328,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.935111111111111,0.030884745856213442,0.0031014621178555605,,9.958124485353391,0.0,17.0,0.0,1.0,Nucleotide-sugar donor-binding loop,True,assigned_and_evaluated +1853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Primase-helicase coupling modules,False,no_term_above_threshold +1854,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M23/LytM catalytic beta-strand marker,False,no_term_above_threshold +1855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse PLSCR cytoplasmic activation,False,no_term_above_threshold +1856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycine-rich transmembrane helices,False,no_term_above_threshold +1857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble domains of membrane proteins,False,no_term_above_threshold +1858,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EndoU catalytic domain marker,False,no_term_above_threshold +1859,-1,,,,,-1,,,0,,,,,,,,,,,,,,,bis-MGD molybdoenzyme catalytic cores,False,no_term_above_threshold +1860,45288,25.364634,0.9838867,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9838867,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,16.0,16.0,462.17829457364337,1.1105476792425275e-42,REC domain active-site loops,True,assigned_too_few_test_positives +1861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization helices,False,no_term_above_threshold +1862,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sirtuin NAD+-binding catalytic core,False,no_term_above_threshold +1863,87586,18.188805,0.72216797,Host membrane,keyword,88161,Transmembrane helix,0.6723633,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7446676406135865,0.09111978612482863,0.01639344262295082,,5.558306953614546,0.0,17.0,0.0,1.0,Single-pass membrane anchor helix,True,assigned_and_evaluated +1864,36115,22.709682,0.8730469,BTB/POZ domain,interpro,64148,Winged helix DNA-binding domain superfamily,0.7661133,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,16.0,0.0,1.0,N-terminal PAS/LOV/H-NOX sensors,True,assigned_too_few_test_positives +1865,37020,20.44289,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.8901367,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,10.0,14.0,583.3757338551859,1.2696071778589582e-26,Nucleotide-sugar glycosyltransferase catalytic cores,True,assigned_too_few_test_positives +1866,48767,15.756759,0.9013672,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9013672,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,18.0,0.0,1.0,Extracellular PA14 and collagen-binding domains,True,assigned_too_few_test_positives +1867,85649,35.75715,0.87060547,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8676758,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8015452882332335,0.6126832463254416,0.0101905183872397,0.6086956521739131,60.122873345935716,16.0,16.0,110.61410018552876,7.117153535323136e-33,Class I MTase N-terminal activation,True,assigned_and_evaluated +1868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding loop,False,no_term_above_threshold +1869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glu-anchored active-site motifs,False,no_term_above_threshold +1870,43626,15.970339,0.91015625,Putative DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8466797,26,ip,IPR009061,interpro:ip:IPR009061,5.0,2257.0,0.9753108348134991,0.052698412698412696,0.002215330084182543,,23.788063492063493,0.0,19.0,0.0,1.0,Short amphipathic interaction helices,True,assigned_and_evaluated +1871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Sec TonB-box leader,False,no_term_above_threshold +1872,72011,19.137617,0.9506836,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9506836,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,Transporter TM helix interfaces,True,assigned_too_few_test_positives +1873,64058,27.095463,0.9897461,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9770508,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9967995669065665,0.5735768200053915,0.006202924235711121,0.7142857142857143,92.4687773394406,15.0,16.0,106.87320745697896,6.820886659830516e-30,N-terminal Rossmann beta-strand hydrophobics,True,assigned_and_evaluated +1874,37282,16.773706,0.9926758,Leucine-rich repeat,interpro,88009,Repeat,0.68066406,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,7.0,16.0,97.69358614232209,8.176634051116559e-13,LRR and ankyrin scaffolds,True,assigned_too_few_test_positives +1875,64058,25.05935,0.7373047,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.73583984,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9157060059868798,0.23512577693340395,0.006202924235711121,0.07142857142857142,37.905634181335195,15.0,16.0,106.87320745697896,6.820886659830516e-30,Mid-sequence substrate-binding Rossmann segment,True,assigned_and_evaluated +1876,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-capped TM helices,False,no_term_above_threshold +1877,36914,17.01443,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9321289,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,DXD-like glycosyltransferase donor loop,True,assigned_too_few_test_positives +1878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal disordered low-complexity regions,False,no_term_above_threshold +1879,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HUH nuclease/relaxase domain recognizer,False,no_term_above_threshold +1880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory disordered segments,False,no_term_above_threshold +1881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-biased transmembrane transport cores,False,no_term_above_threshold +1882,37894,16.980507,0.7260742,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7260742,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Cofactor-attachment/interface domains,True,assigned_too_few_test_positives +1883,36499,15.854925,0.9921875,"Zinc finger, GATA-type",interpro,88261,Zinc,0.75390625,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,20.0,0.0,1.0,Cys/His-rich metal-binding loops,True,assigned_too_few_test_positives +1884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane amphipathic helix,False,no_term_above_threshold +1885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TM1 signal-anchor helix,False,no_term_above_threshold +1886,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATPase motor N-terminal anchors,False,no_term_above_threshold +1887,58239,16.932138,0.6713867,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6713867,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7318391971132161,0.07824485694460702,0.017722640673460344,,4.414966053099452,0.0,16.0,0.0,1.0,Active-site rim capping loop,True,assigned_and_evaluated +1888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+/Lon noncatalytic residue peaks,False,no_term_above_threshold +1889,36951,16.72318,0.8828125,SET domain,interpro,36951,SET domain,0.8828125,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,12.0,0.0,1.0,Catalytic-adjacent flexible linkers,True,assigned_too_few_test_positives +1890,84879,17.439175,0.8955078,"Histidine kinase-like ATPase, C-terminal domain",gene3d,84879,"Histidine kinase-like ATPase, C-terminal domain",0.8955078,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,17.0,17.0,327.5879120879121,1.027565445798913e-42,Histidine kinase CA C-terminus,True,assigned_too_few_test_positives +1891,37341,20.106268,0.94921875,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8725586,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9882411559541604,0.3901595964992459,0.011962782454585734,0.4074074074074074,32.614452196251776,13.0,18.0,105.02344173441733,1.5699660829275456e-24,Eukaryotic low-complexity assembly linkers,True,assigned_and_evaluated +1892,87882,17.328623,0.6870117,Palmitate,keyword,87882,Palmitate,0.6870117,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9874870427957945,0.4015151515151515,0.002658396101019052,0.3333333333333333,151.03661616161614,5.0,17.0,19.5928360170884,7.585078111925293e-06,Non-cytosolic interaction patch,True,assigned_and_evaluated +1893,64620,16.536755,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.82373047,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,17.0,324.0271739130435,1.225281491287518e-42,GHKL ATP-lid hinge motif,True,assigned_too_few_test_positives +1894,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding core secondary structure,False,no_term_above_threshold +1895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular aromatic-threonine motifs,False,no_term_above_threshold +1896,85364,22.905682,0.86572266,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.86572266,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,15.0,16.0,282.29640151515156,3.4498713320022935e-36,C-terminal extracytoplasmic cleft-bordering segments,True,assigned_too_few_test_positives +1897,61392,18.638725,0.99902344,Leucine-rich repeat domain superfamily,interpro,85649,Vaccinia Virus protein VP39,0.8203125,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9985396825396824,0.5314986600700886,0.0031014621178555605,1.0,171.37035368259856,16.0,20.0,133.97977528089888,3.782270337128945e-32,LRR/solenoid boundary spikes,True,assigned_and_evaluated +1898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic helical gating subdomain,False,no_term_above_threshold +1899,86130,16.80591,0.9394531,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,88150,Transcription regulation,0.63134766,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9942222222222222,0.22559001670843776,0.0031014621178555605,,72.73666681584915,0.0,17.0,0.0,1.0,TF C-terminal effector modules,True,assigned_and_evaluated +1900,45551,17.198494,0.7011719,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7011719,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,17.0,0.0,1.0,Walker B loop-helix switch,True,assigned_too_few_test_positives +1901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic β-strand–loop platform,False,no_term_above_threshold +1902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP post-lysine beta-strand/turn,False,no_term_above_threshold +1903,37282,17.82962,0.9326172,Leucine-rich repeat,interpro,37446,F-box domain,0.8432617,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,5.0,12.0,93.04151061173533,2.745867254068989e-09,Leucine-rich repeat domains,True,assigned_too_few_test_positives +1904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structural landmark residues,False,no_term_above_threshold +1905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD Q-loop/coupling region,False,no_term_above_threshold +1906,58239,22.794937,0.60253906,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.60253906,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6484833107803337,0.2964340261760705,0.017722640673460344,0.3,16.72628992698478,20.0,20.0,35.851473241130485,2.9591156525725853e-31,Electropositive anion-binding inserts,True,assigned_and_evaluated +1907,88058,28.395052,0.67041016,Signal,keyword,88058,Signal,0.67041016,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6430559566017997,0.1146607995507536,0.09127159946832078,,1.2562593426507325,4.0,19.0,1.5168325647956749,0.4167641580369206,IDRs and signal peptides,True,assigned_and_evaluated +1908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral C-terminal lid appendages,False,no_term_above_threshold +1909,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal cytosolic helical scaffolds,False,no_term_above_threshold +1910,49230,37.296944,0.9838867,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.9838867,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,16.0,18.0,249.98322851153037,3.4964212311447665e-37,Acyl-donor entry segment,True,assigned_too_few_test_positives +1911,47529,17.4409,0.88134766,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.88134766,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.893100178491745,0.0358269624233219,0.007089056269384138,,5.053840886839846,0.0,14.0,0.0,1.0,Solvent-exposed beta-sheet edges,True,assigned_and_evaluated +1912,45804,17.215788,0.84765625,Major facilitator superfamily,interpro,82029,MFS general substrate transporter like domains,0.82470703,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix boundary linkers,True,assigned_too_few_test_positives +1913,50338,15.771118,0.95703125,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9375,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,16.0,18.0,348.6608187134503,1.697096145792369e-39,GPCR N-terminal extracellular hinge,True,assigned_too_few_test_positives +1914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DE-rich acidic IDR tails,False,no_term_above_threshold +1915,4066,23.680624,0.9042969,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9042969,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.6931172291296624,0.1679958647171762,0.002215330084182543,0.4,75.83333333333334,5.0,15.0,239.44176706827307,2.948805674286966e-11,Lys/Arg-rich polyanion-binding patches,True,assigned_and_evaluated +1916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich helix capping loops,False,no_term_above_threshold +1917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket lining core helices,False,no_term_above_threshold +1918,82029,29.071291,0.9941406,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Short hydrophobic MFS TM/loop helices,True,assigned_too_few_test_positives +1919,46277,16.191021,0.6567383,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.6567383,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.7665546830729376,0.12063644953169494,0.004873726185201595,,24.75240605391232,0.0,11.0,0.0,1.0,Non-catalytic helicase binding regions,True,assigned_and_evaluated +1920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix proximal motifs,False,no_term_above_threshold +1921,38317,21.477451,0.82470703,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.82470703,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6387301587301586,0.2879296157984682,0.0031014621178555605,0.2857142857142857,92.83673469387753,0.0,12.0,0.0,1.0,Solenoid repeats and linkers,True,assigned_and_evaluated +1922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered repeats,False,no_term_above_threshold +1923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge acidic interface helix,False,no_term_above_threshold +1924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidoglycan hydrolase catalytic helix,False,no_term_above_threshold +1925,87149,18.835522,0.6845703,Amphibian defense peptide,keyword,87162,Antimicrobial,0.6660156,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6756793565339999,0.11466907607360555,0.012405848471422242,,9.243146596361704,0.0,16.0,0.0,1.0,Hydrophobic coiled-coil helix face,True,assigned_and_evaluated +1926,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar helix-capping linkers,False,no_term_above_threshold +1927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand edges and junctions,False,no_term_above_threshold +1928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic C-terminal helical scaffold,False,no_term_above_threshold +1929,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved cytosolic TM-adjacent motifs,False,no_term_above_threshold +1930,88058,20.146395,0.6176758,Signal,keyword,88058,Signal,0.6176758,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.615824390659541,0.11607608267051862,0.09127159946832078,,1.271765624210488,2.0,18.0,0.8005505203088285,1.0,C-terminal proline-rich regulatory motifs,True,assigned_and_evaluated +1931,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-recognition cavity surface,False,no_term_above_threshold +1932,37894,16.560099,0.83984375,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.83984375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,19.0,0.0,1.0,Phosphate-binding Lys–Gly–acidic motif,True,assigned_too_few_test_positives +1933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cleft loop-helix segments,False,no_term_above_threshold +1934,52236,17.80953,0.9916992,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99121094,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,17.0,197.0290812954395,2.448847296887054e-33,Repeat helix caps and linkers,True,assigned_too_few_test_positives +1935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C transmembrane helix-loop junctions,False,no_term_above_threshold +1936,36091,19.402197,0.79345703,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.7890625,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,13.0,17.0,288.560312732688,1.753169961880017e-30,GNAT N-terminal substrate pocket,True,assigned_too_few_test_positives +1937,27013,28.691526,0.9506836,side of membrane,go_cc,87489,GPI-anchor,0.9506836,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.823559899304013,0.162356531004072,0.002658396101019052,,61.073115079365074,0.0,20.0,0.0,1.0,C-terminal juxtamembrane disordered stalk,True,assigned_and_evaluated +1938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix near metal channel,False,no_term_above_threshold +1939,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered TF linker MoRFs,False,no_term_above_threshold +1940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane interface helix caps,False,no_term_above_threshold +1941,27733,19.80062,0.84521484,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.6425781,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.9237086917597602,0.34527643303499256,0.0101905183872397,0.08695652173913043,33.8821264939121,16.0,18.0,47.74454454454454,8.630026125631021e-26,C-terminal low-complexity TF IDRs,True,assigned_and_evaluated +1942,82597,32.97262,0.95947266,Tetratricopeptide repeat domain,gene3d,46079,Tetratricopeptide-like helical domain superfamily,0.9550781,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9927327574386398,0.39772603191367495,0.0057598582188746125,0.38461538461538464,69.0513580022434,13.0,19.0,66.65574475404196,8.666454241313705e-22,Solenoid and propeller boundary loops,True,assigned_and_evaluated +1943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-to-beta boundary motifs,False,no_term_above_threshold +1944,15821,17.14105,0.6953125,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6953125,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,19.0,0.0,1.0,G/P/Y/S low-complexity regions,True,assigned_too_few_test_positives +1945,32577,15.762078,0.67626953,protein heterodimerization activity,go_mf,32577,protein heterodimerization activity,0.67626953,39,go,GO:0046982,go_mf:go:GO:0046982,,,,,,,,7.0,12.0,85.66235632183908,1.096694672913353e-12,Histone-fold and basic tails,True,assigned_too_few_test_positives +1946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sandwich strand-loop scaffolds,False,no_term_above_threshold +1947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix boundary transition signal,False,no_term_above_threshold +1948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FtsK1 ATPase motif activation,False,no_term_above_threshold +1949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PMT FxRFLDxxQY helix,False,no_term_above_threshold +1950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil interaction segments,False,no_term_above_threshold +1951,82029,16.981735,0.8261719,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.65625,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,Signal-anchor transmembrane helix,True,assigned_too_few_test_positives +1952,88161,63.485054,0.73828125,Transmembrane helix,keyword,88161,Transmembrane helix,0.73828125,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7990824731519132,0.6226554218884712,0.1847585290208241,0.6810551558752997,3.3701038062404787,14.0,14.0,5.4274920345926265,1.0920821671226735e-10,Transmembrane helix entry motif,True,assigned_and_evaluated +1953,45288,17.759138,0.9838867,CheY-like superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7314453,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,15.0,15.0,462.17829457364337,3.960299025280445e-40,Receiver β4–α4 switch-loop,True,assigned_too_few_test_positives +1954,38317,17.86643,0.8730469,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8730469,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6849206349206348,0.026767950747815322,0.0031014621178555605,,8.630752119688454,0.0,12.0,0.0,1.0,C-terminal acidic amphipathic patch,True,assigned_and_evaluated +1955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-acidic catalytic pockets,False,no_term_above_threshold +1956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic amphipathic interaction helices,False,no_term_above_threshold +1957,87856,16.551214,0.75097656,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.75097656,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5177529962186759,0.04723400215203494,0.012405848471422242,0.07142857142857142,3.8073979591836733,10.0,16.0,52.930575284090914,8.81523241797706e-16,Cyclase and TERT pan-domain activation,True,assigned_and_evaluated +1958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory extensions,False,no_term_above_threshold +1959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-capping helices and loops,False,no_term_above_threshold +1960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-WD alpha-solenoid tails,False,no_term_above_threshold +1961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ValRS catalytic hydrophobic loop,False,no_term_above_threshold +1962,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal secondary structure hotspot,False,no_term_above_threshold +1963,37894,25.677181,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7993164,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR domain boundary segments,True,assigned_too_few_test_positives +1964,52236,28.256004,0.99853516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99316406,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR A-helix hydrophobic core,True,assigned_too_few_test_positives +1965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane hairpins and anchors,False,no_term_above_threshold +1966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal basic topogenic segments,False,no_term_above_threshold +1967,45714,22.228138,0.9995117,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.9995117,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,18.0,18.0,298.105,2.3937574540158956e-44,Disordered transcriptional effector domains,True,assigned_too_few_test_positives +1968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,QueD/PTPS C-terminal charge-relay,False,no_term_above_threshold +1969,64026,16.481298,0.78125,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.66796875,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9336220938841997,0.2100376423837726,0.002658396101019052,0.16666666666666666,79.00915981002912,1.0,20.0,8.468892045454545,0.18012505039439194,Hydrophobic TM helix cores,True,assigned_and_evaluated +1970,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered tails,False,no_term_above_threshold +1971,37894,18.33491,0.9399414,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.72265625,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR YXXXK catalytic motif,True,assigned_too_few_test_positives +1972,49116,24.404087,0.97265625,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97265625,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9994671403197157,0.6861904761904761,0.002215330084182543,1.0,309.74638095238095,19.0,19.0,87.03795620437957,6.605101239071875e-37,HEAT/ARM alpha-solenoid repeats,True,assigned_and_evaluated +1973,45714,23.948767,0.9892578,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.9892578,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,18.0,0.0,1.0,Zinc metallopeptidase catalytic helix,True,assigned_too_few_test_positives +1974,25884,15.932057,0.71240234,host cell membrane,go_cc,88161,Transmembrane helix,0.65771484,259,go,GO:0033644,go_cc:go:GO:0033644,24.0,2257.0,0.8208501268846097,0.12854627164071022,0.010633584404076208,,12.088705628878456,1.0,12.0,11.139947683109117,0.1401102800268536,Transmembrane helix hairpins,True,assigned_and_evaluated +1975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil stalks,False,no_term_above_threshold +1976,36535,24.21603,0.9658203,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.96435547,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9493101913662659,0.8793319549057254,0.004430660168365086,0.9,198.46522222222222,15.0,15.0,89.79066265060241,1.585928718533337e-29,Kinase C-lobe proline motif,True,assigned_and_evaluated +1977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Envelope proline-rich linkers,False,no_term_above_threshold +1978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CLE motif and TM hydrophobics,False,no_term_above_threshold +1979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic loop hotspots,False,no_term_above_threshold +1980,87326,40.832428,0.8071289,Coiled coil,keyword,87326,Coiled coil,0.8071289,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8333963887391682,0.39533204317904824,0.03943287549844927,0.24719101123595505,10.025442937697887,16.0,19.0,10.616865699880913,4.307920495700391e-15,Soluble coiled-coil scaffolds,True,assigned_and_evaluated +1981,85649,28.16428,0.9692383,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9628906,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9491456151959831,0.61428101180232,0.0101905183872397,0.7391304347826086,60.27966276686244,0.0,11.0,0.0,1.0,SDR Rossmann-loop signature,True,assigned_and_evaluated +1982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-B alpha-selectivity loop,False,no_term_above_threshold +1983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil interface helices,False,no_term_above_threshold +1984,81685,15.849559,0.96191406,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.91552734,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.972735708982925,0.43325079302722724,0.005316792202038104,0.3333333333333333,81.48725332187098,2.0,10.0,17.13247126436782,0.009884822052729302,Conserved β-strand core detector,True,assigned_and_evaluated +1985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved PPxxxNP acyl-CoA motif,False,no_term_above_threshold +1986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal peptide ectodomain N-terminus,False,no_term_above_threshold +1987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic P-type ATPase A-domain,False,no_term_above_threshold +1988,64146,23.84402,0.6777344,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6777344,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.5998957868095877,0.024426233577441517,0.007975188303057155,,3.0627782880158616,16.0,17.0,62.907939857557366,3.1802434053521716e-28,DNA-binding recognition helix,True,assigned_and_evaluated +1989,81858,16.601433,0.9716797,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.8017578,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +1990,27733,17.252874,0.77441406,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.77441406,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.7486181931415672,0.18230418522825992,0.0101905183872397,0.2608695652173913,17.889588959138376,12.0,19.0,33.923755334281644,1.75809718956245e-16,Disordered transcriptional activation regions,True,assigned_and_evaluated +1991,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan transfer aromatic TM helices,False,no_term_above_threshold +1992,36876,15.638647,0.98291016,Cytochrome P450,interpro,36876,Cytochrome P450,0.98291016,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,0.0,16.0,0.0,1.0,Short charged amphipathic helices,True,assigned_and_evaluated +1993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-flanking phospho-regulatory IDRs/coiled-coils,False,no_term_above_threshold +1994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/IDR assembly scaffolds,False,no_term_above_threshold +1995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic disordered RNA-binding arms,False,no_term_above_threshold +1996,84152,27.1946,0.88378906,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.88378906,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,15.0,15.0,562.4622641509434,2.0575595524537636e-41,Acidic/His metal-binding patch,True,assigned_too_few_test_positives +1997,87857,22.794804,0.62597656,Nucleus,keyword,87857,Nucleus,0.62597656,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6439521913418869,0.20565652807621193,0.06247230837394772,0.2553191489361702,3.291963006156102,19.0,20.0,5.7560924796747965,5.183410498242789e-14,Broad activation across nuclear coactivators,True,assigned_and_evaluated +1998,87149,22.008362,0.6933594,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6933594,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8565580337114658,0.2120096653952831,0.012405848471422242,0.21428571428571427,17.08949338561264,0.0,19.0,0.0,1.0,Extended disordered targeting/effector regions,True,assigned_and_evaluated +1999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,c-type cytochrome capping helices,False,no_term_above_threshold +2000,49236,32.12486,0.9267578,C-type lectin fold,interpro,49236,C-type lectin fold,0.9267578,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,15.0,15.0,542.0090909090909,3.648558958891665e-41,Aromatic cysteine ligand-binding loop,True,assigned_and_evaluated +2001,87108,18.990646,0.87939453,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.8652344,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9254398971925663,0.19983223036712322,0.003987594151528578,,50.113482659844124,0.0,20.0,0.0,1.0,Terminal export/translocation signals,True,assigned_and_evaluated +2002,59224,15.726253,0.87597656,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7939453,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.982031746031746,0.09856048486367636,0.0031014621178555605,,31.778716333902505,0.0,15.0,0.0,1.0,Beta-strand N-cap recognition,True,assigned_and_evaluated +2003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase core detector,False,no_term_above_threshold +2004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active-site micro-motifs,False,no_term_above_threshold +2005,72011,21.635967,0.9633789,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.9399414,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Active-site groove-lining segments,True,assigned_too_few_test_positives +2006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular enzyme active-site pocket,False,no_term_above_threshold +2007,84152,24.675072,0.96777344,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.96777344,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,15.0,15.0,562.4622641509434,2.0575595524537636e-41,Metal-dependent hydrolase gating loops,True,assigned_too_few_test_positives +2008,59211,19.828007,0.7685547,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7685547,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.6543458781362007,0.07608435486591318,0.011076650420912717,,6.868895557294642,12.0,12.0,244.34836065573774,5.995059269999983e-29,Glycosyltransferase donor-loop tail signature,True,assigned_and_evaluated +2009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aconitase/IlvD Fe–S scaffold,False,no_term_above_threshold +2010,88160,17.065262,0.8251953,Transmembrane beta strand,keyword,25167,cell outer membrane,0.69384766,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,17.0,221.32295830953737,5.721118510676694e-29,Bacterial outer-membrane beta-barrels,True,assigned_too_few_test_positives +2011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS helix C-cap motif,False,no_term_above_threshold +2012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interhelical linker activation,False,no_term_above_threshold +2013,85682,20.0409,0.63916016,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.63916016,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8769892473118279,0.5089888665984588,0.011076650420912717,0.76,45.95151487650885,14.0,15.0,95.4481417953116,3.0569549950337758e-27,E1 PLGVPHQ catalytic Cys,True,assigned_and_evaluated +2014,87465,18.032076,0.9057617,Fimbrium,keyword,87465,Fimbrium,0.9057617,47,keywords,Fimbrium,keyword:keywords:Fimbrium,5.0,2257.0,0.7633214920071048,0.0182167724702923,0.002215330084182543,,8.223051093089945,0.0,18.0,0.0,1.0,Disordered N-terminal assembly/export tail,True,assigned_and_evaluated +2015,48767,21.566793,0.9682617,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9682617,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,16.0,0.0,1.0,OB/S1 ssNA-binding proteins,True,assigned_too_few_test_positives +2016,37020,17.21086,0.96875,"Glycosyl transferase, family 1",interpro,81685,Transferase(Phosphotransferase) domain 1,0.94921875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,15.0,0.0,1.0,Histidine kinase N-box helix,True,assigned_too_few_test_positives +2017,50338,18.67459,0.97509766,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9716797,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,2.0,18.0,43.582602339181285,0.0016918995107513132,TM4 helix start detector,True,assigned_too_few_test_positives +2018,36977,17.327076,0.96435547,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.92089844,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,2.0,13.0,47.77323717948718,0.001387652576973418,Kinase alphaF hydrophobic anchor,True,assigned_too_few_test_positives +2019,36449,17.908768,1.0,EamA domain,interpro,64026,MFS transporter superfamily,0.7993164,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,15.0,19.0,840.5216165413534,2.288000093252355e-42,Transporter helix-entry interface motif,True,assigned_too_few_test_positives +2020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand initiation motif,False,no_term_above_threshold +2021,87586,16.449787,0.6557617,Host membrane,keyword,88159,Transmembrane,0.625,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7401996591185781,0.18760876341343033,0.01639344262295082,0.35135135135135137,11.44413456821925,1.0,20.0,3.2297399783315277,0.42083436547341024,Positive-inside juxtamembrane interface,True,assigned_and_evaluated +2022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled coil hydrophobic stripe,False,no_term_above_threshold +2023,88051,18.738325,0.6015625,Serine protease inhibitor,keyword,88051,Serine protease inhibitor,0.6015625,109,keywords,Serine protease inhibitor,keyword:keywords:Serine protease inhibitor,,,,,,,,0.0,17.0,0.0,1.0,Active-site proximal segment,True,assigned_too_few_test_positives +2024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scattered activations in small/processed proteins,False,no_term_above_threshold +2025,47128,16.00283,0.9394531,Concanavalin A-like lectin/glucanase domain superfamily,interpro,64016,Thioredoxin-like superfamily,0.89453125,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,2.0,16.0,32.12338362068965,0.003039633414730782,Asx-Gly beta-turn motif,True,assigned_too_few_test_positives +2026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sheet-rich surface structural proteins,False,no_term_above_threshold +2027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical domain-coupling segments,False,no_term_above_threshold +2028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad post-transmembrane activation,False,no_term_above_threshold +2029,36535,18.547586,0.8466797,Protein kinase domain,interpro,36535,Protein kinase domain,0.8466797,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.7927458834000891,0.137341300294277,0.004430660168365086,,30.99793147641832,0.0,6.0,0.0,1.0,ABC NBD signature helix,True,assigned_and_evaluated +2030,25169,20.265747,0.8701172,pilus,go_cc,25169,pilus,0.8701172,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.897380106571936,0.7004430660168366,0.002215330084182543,0.8,316.18000000000006,5.0,18.0,153.34619341563786,3.1249953171619833e-10,Extracellular beta-strand-rich ectodomains,True,assigned_and_evaluated +2031,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structured core detector,False,no_term_above_threshold +2032,27733,16.776695,0.7705078,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.7705078,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.7135767389358141,0.06458882099343129,0.0101905183872397,,6.338129086181496,2.0,15.0,7.1616816816816815,0.051484131098985,Disordered activation tails flanking domains,True,assigned_and_evaluated +2033,52236,20.068851,0.9975586,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99365234,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR helix-B N-cap,True,assigned_too_few_test_positives +2034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha helix interiors,False,no_term_above_threshold +2035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Heme/Ca2+-binding peroxidase domains,False,no_term_above_threshold +2036,37894,19.434668,0.9379883,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8105469,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,NAD-adjacent β–α loop-lid,True,assigned_too_few_test_positives +2037,64585,17.085096,0.9951172,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.98339844,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,12.0,18.0,451.67424242424244,3.44845069889384e-30,IDR regulatory tails; metal-core suppression,True,assigned_too_few_test_positives +2038,27735,16.186506,0.78564453,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,88150,Transcription regulation,0.6430664,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.8700306864807089,0.08065903789627152,0.011519716437749225,,7.001824943534031,7.0,20.0,15.832587253414262,2.9991424236129796e-07,Disordered low-complexity regulatory regions,True,assigned_and_evaluated +2039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme active-site clefts,False,no_term_above_threshold +2040,59229,33.796356,0.9819336,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9819336,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8837238721731345,0.7434013829096876,0.0101905183872397,0.7391304347826086,72.9503009229202,16.0,17.0,100.02474572716787,2.1086661383518e-31,Glycine-rich SAM-binding motif I,True,assigned_and_evaluated +2041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered T/V/I-rich patches,False,no_term_above_threshold +2042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming/fusogenic N-terminal signature,False,no_term_above_threshold +2043,36499,20.642298,0.91552734,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.91552734,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,17.0,0.0,1.0,PAS-domain connector helices,True,assigned_too_few_test_positives +2044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundary motif,False,no_term_above_threshold +2045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PI-PLC X-box catalytic motif,False,no_term_above_threshold +2046,3604,16.687044,0.9145508,non-specific serine/threonine protein kinase,ec,45290,Protein kinase-like domain superfamily,0.9008789,57,ec,2.7.11.1,ec:ec:2.7.11.1,7.0,2257.0,0.9242857142857144,0.2591551872289577,0.0031014621178555605,0.14285714285714285,83.55903679653679,0.0,16.0,0.0,1.0,Kinase N-lobe alphaC helix,True,assigned_and_evaluated +2047,64475,21.865582,1.0,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.9682617,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9922528451940217,0.26848040285359404,0.0057598582188746125,,46.61232840312013,0.0,16.0,0.0,1.0,Cationic histidine-rich helical surfaces,True,assigned_and_evaluated +2048,87326,27.69598,0.6298828,Coiled coil,keyword,87326,Coiled coil,0.6298828,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.658617169036859,0.1488407211965363,0.03943287549844927,,3.774533794838005,12.0,18.0,8.40501867907239,1.4878219757400116e-09,Coiled-coil dimerization helix,True,assigned_and_evaluated +2049,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen-like triple-helix recognition,False,no_term_above_threshold +2050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-terminus interfacial loops,False,no_term_above_threshold +2051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic catalytic domains,False,no_term_above_threshold +2052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTPase nucleotide-sensing switch module,False,no_term_above_threshold +2053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal/anchor helices and CPP-like motifs,False,no_term_above_threshold +2054,85364,31.045824,0.9482422,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9482422,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,Venus flytrap hinge core,True,assigned_too_few_test_positives +2055,37894,16.394289,0.93408203,Short-chain dehydrogenase/reductase SDR,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6699219,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,11.0,0.0,1.0,ABC NBD Walker B loop,True,assigned_too_few_test_positives +2056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended repeat-rich scaffolds,False,no_term_above_threshold +2057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic aromatic helix motif,False,no_term_above_threshold +2058,45324,16.334282,0.8876953,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.74560547,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9994671403197157,0.8909090909090909,0.002215330084182543,0.8,402.15636363636366,0.0,17.0,0.0,1.0,Repetitive beta-architectures and coiled-coils,True,assigned_and_evaluated +2059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel loop/edge signature,False,no_term_above_threshold +2060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class II aldolase polar loops,False,no_term_above_threshold +2061,45290,30.921143,0.94873047,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.94873047,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.960492938434115,0.8769665425403131,0.0057598582188746125,0.9230769230769231,152.25488357796053,17.0,20.0,62.41114532019704,6.28912244422708e-29,Kinase catalytic helical subdomain,True,assigned_and_evaluated +2062,72011,16.669167,0.91015625,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.91015625,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,Interfacial TM helix-loop junctions,True,assigned_too_few_test_positives +2063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophilic low-complexity IDRs,False,no_term_above_threshold +2064,29104,15.771339,0.8310547,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.6743164,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,2.0,14.0,61.2754367934224,0.0008573010909345707,Non-cytoplasmic TM-helix entry,True,assigned_too_few_test_positives +2065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transmembrane anchor,False,no_term_above_threshold +2066,45290,28.14796,0.9692383,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9692383,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9602015631427396,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Kinase catalytic-loop HRD/KPEN motif,True,assigned_and_evaluated +2067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SecA WMGP and SH3BGRL helix,False,no_term_above_threshold +2068,37430,24.896357,0.9790039,"Signal transduction response regulator, receiver domain",interpro,37430,"Signal transduction response regulator, receiver domain",0.9790039,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,8.0,12.0,323.14905149051486,3.25197302791589e-19,ABC/RR phosphate switch loops,True,assigned_too_few_test_positives +2069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD LSGGQ signature,False,no_term_above_threshold +2070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mobile lid docking loops,False,no_term_above_threshold +2071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL Bergerat ATP-lid N-lobe,False,no_term_above_threshold +2072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase catalytic core,False,no_term_above_threshold +2073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic C-terminal helical cores,False,no_term_above_threshold +2074,81799,22.594416,0.92626953,1.10.8.60,gene3d,81799,1.10.8.60,0.92626953,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,0.0,20.0,0.0,1.0,AAA+ SRH sensor helix,True,assigned_too_few_test_positives +2075,38317,15.922375,0.85253906,Pentatricopeptide repeat,interpro,63831,F-box-like domain superfamily,0.7529297,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7017777777777778,0.04113914718422915,0.0031014621178555605,,13.264436456400741,0.0,20.0,0.0,1.0,C-terminal LRR/PPR repeat arrays,True,assigned_and_evaluated +2076,64026,15.623038,0.72558594,MFS transporter superfamily,interpro,88159,Transmembrane,0.6171875,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7252702502591442,0.06850027833634391,0.002658396101019052,,25.767521367521365,10.0,20.0,84.68892045454545,1.946014173728693e-17,Mixed-charge terminal disordered tails,True,assigned_and_evaluated +2077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Recombinase core-binding HTH hairpins,False,no_term_above_threshold +2078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-dense disordered interaction hubs,False,no_term_above_threshold +2079,64058,25.739862,0.7011719,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6958008,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7070887204636647,0.18618867083576074,0.006202924235711121,0.14285714285714285,30.016273576879428,15.0,15.0,113.99808795411089,4.589611073054062e-31,Oxidoreductase cofactor-interface core,True,assigned_and_evaluated +2080,87149,18.511919,0.7348633,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.7348633,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7156235980260206,0.026893474074181918,0.012405848471422242,,2.1678061066224497,0.0,16.0,0.0,1.0,AAA+ helical interaction hotspots,True,assigned_and_evaluated +2081,87326,34.8221,0.68847656,Coiled coil,keyword,87326,Coiled coil,0.68847656,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6763340105311166,0.26434209711040835,0.03943287549844927,0.2808988764044944,6.703596777283052,17.0,19.0,11.28041980612347,6.733872062658451e-17,Polar coiled-coil tethers,True,assigned_and_evaluated +2082,83267,22.052322,0.9345703,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.9345703,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,16.0,0.0,1.0,Conserved internal interaction surface,True,assigned_too_few_test_positives +2083,55053,20.081621,0.91015625,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.91015625,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,16.0,0.0,1.0,N-terminal beta/alpha domain signal,True,assigned_too_few_test_positives +2084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD N-terminal membrane-proximal loop,False,no_term_above_threshold +2085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteobacterial acidic proline-rich pre-TM tails,False,no_term_above_threshold +2086,63951,19.621862,0.96484375,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9604492,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9964659944642151,0.37581200475937315,0.003987594151528578,,94.24529941576725,0.0,18.0,0.0,1.0,Extracellular interdomain linkers and stalks,True,assigned_and_evaluated +2087,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sugar-phosphate cyclase catalytic helix,False,no_term_above_threshold +2088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich loop motifs,False,no_term_above_threshold +2089,88159,19.74485,0.6044922,Transmembrane,keyword,87760,Membrane,0.60009766,4311,keywords,Transmembrane,keyword:keywords:Transmembrane,421.0,2257.0,0.4886520060650283,0.17889707555803994,0.18653079308817014,,0.9590752958064042,9.0,18.0,2.640200159419006,0.004979811221976876,Extreme C-terminal basic residues,True,assigned_and_evaluated +2090,85672,19.27638,0.74853516,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7324219,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.743139976987343,0.06311785867431625,0.01595037660611431,,3.9571390841092167,0.0,18.0,0.0,1.0,Aromatic shelf with acidic anchor,True,assigned_and_evaluated +2091,47717,17.316473,0.98095703,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6357422,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,14.0,273.49082568807336,2.439567240558689e-34,P-loop motor flanking IDRs,True,assigned_too_few_test_positives +2092,88263,42.086937,0.9482422,Zinc-finger,keyword,29166,zinc ion binding,0.9165039,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.976414323086985,0.23897110249527956,0.014621178555604785,,16.34417510096503,5.0,17.0,7.664155697243933,0.0006223220485610781,AlaRS N-terminal FFxxxGF/Y motif,True,assigned_and_evaluated +2093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/H-rich adaptor N-termini activation,False,no_term_above_threshold +2094,88161,32.623264,0.6557617,Transmembrane helix,keyword,88161,Transmembrane helix,0.6557617,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6760863048691482,0.34470237026659795,0.1847585290208241,0.09352517985611511,1.8656912462630972,13.0,13.0,5.4274920345926265,5.833912717653736e-10,Hydrophobic transmembrane helix residues,True,assigned_and_evaluated +2095,85672,16.197247,0.6826172,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.67626953,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7642578418129972,0.17729478441423,0.01595037660611431,0.1111111111111111,11.115398011747697,3.0,20.0,6.002114093959731,0.02196229477626943,Serine-centered leucine-rich helical motif,True,assigned_and_evaluated +2096,64585,18.049316,0.7817383,"Zinc finger, CCCH-type superfamily",interpro,64585,"Zinc finger, CCCH-type superfamily",0.7817383,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,18.0,0.0,1.0,SLH cell-wall anchoring domains,True,assigned_too_few_test_positives +2097,85675,20.66481,0.9506836,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.92871094,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,17.0,18.0,516.5937818552497,3.251667628033392e-45,VWA/MIDAS-like binding surfaces,True,assigned_too_few_test_positives +2098,85672,21.785496,0.7993164,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.79345703,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7826554605032767,0.07678795268943667,0.01595037660611431,,4.814178033890515,3.0,19.0,6.3180148357470856,0.019055663302813962,Kinase N-lobe basic cluster,True,assigned_and_evaluated +2099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosyltransferase helix-capping interfacial motifs,False,no_term_above_threshold +2100,87326,22.622786,0.6455078,Coiled coil,keyword,87326,Coiled coil,0.6455078,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6163061279489199,0.06860604432604124,0.03943287549844927,,1.7398184499311808,1.0,18.0,0.7004182232560325,1.0,DHp H-box helix,True,assigned_and_evaluated +2101,85664,15.95519,0.9555664,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.86279297,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,2.0,17.0,38.96797385620915,0.0020949709487805184,Aromatic-Cys/Ser/Thr beta-strand cleft motif,True,assigned_too_few_test_positives +2102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Linker initiated strand start motif,False,no_term_above_threshold +2103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse activation in secreted proteins,False,no_term_above_threshold +2104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal helicase/nuclease region,False,no_term_above_threshold +2105,85672,37.996574,0.9628906,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.96240234,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.953461904047226,0.5784078002544637,0.01595037660611431,0.75,36.26295569928679,4.0,17.0,9.41508093170154,0.0012587916594561115,Kinesin motor basic-Thr loop,True,assigned_and_evaluated +2106,30856,16.75973,0.87060547,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.83691406,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.8928952042628774,0.10994986847245303,0.002215330084182543,0.2,49.6313706284653,1.0,16.0,8.37373595505618,0.18200205763873273,Transmembrane helix boundary motifs,True,assigned_and_evaluated +2107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding buttress helix,False,no_term_above_threshold +2108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial toxin and PIPK domain,False,no_term_above_threshold +2109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic multipass membrane loops,False,no_term_above_threshold +2110,36668,16.002872,0.90478516,AMP-dependent synthetase/ligase domain,interpro,36668,AMP-dependent synthetase/ligase domain,0.90478516,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,14.0,0.0,1.0,Disordered phospho-regulatory regions,True,assigned_too_few_test_positives +2111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site ligand-binding patch,False,no_term_above_threshold +2112,87317,15.96497,0.6455078,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.6455078,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.7303937974118697,0.06623713145229539,0.007089056269384138,,9.343575355489419,3.0,20.0,12.667351274787535,0.002826531700851094,Gly-rich linkers and Walker A,True,assigned_and_evaluated +2113,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal polybasic regulatory modules,False,no_term_above_threshold +2114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chromodomain and integrase-proximal activation,False,no_term_above_threshold +2115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane redox and metal transport,False,no_term_above_threshold +2116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic oligomerization helices,False,no_term_above_threshold +2117,25169,15.881104,0.7001953,pilus,go_cc,25169,pilus,0.7001953,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8904085257548846,0.09123671681048731,0.002215330084182543,,41.18425396825398,0.0,14.0,0.0,1.0,Conserved TLDc domain core,True,assigned_and_evaluated +2118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pocket-lining helices,False,no_term_above_threshold +2119,59229,16.336527,0.8701172,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7890625,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8735452103849597,0.04497667438261992,0.0101905183872397,,4.413580612242312,1.0,19.0,5.593489070269255,0.2610217039729154,Internal catalytic-domain alpha-helix in CAZymes,True,assigned_and_evaluated +2120,85682,16.652042,0.83251953,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.83251953,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9677956989247312,0.1704072048912488,0.011076650420912717,,15.384362457581942,0.0,16.0,0.0,1.0,Oxyanion-binding catalytic sites,True,assigned_and_evaluated +2121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TyrRS AKE(D/E)FxxRY motif,False,no_term_above_threshold +2122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,JmjC VxxFP beta-strand,False,no_term_above_threshold +2123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FliD/HAP2 C-terminal coiled-coil,False,no_term_above_threshold +2124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ku70/PIN DNA-repair signature,False,no_term_above_threshold +2125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic membrane-binding helices,False,no_term_above_threshold +2126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +2127,85364,25.589748,0.96777344,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.96777344,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,11.0,18.0,184.01543209876544,3.620616776438465e-23,Allosteric VFT/ACT hinge regions,True,assigned_too_few_test_positives +2128,38317,27.99087,0.9941406,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9941406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9197777777777779,0.16522669508617985,0.0031014621178555605,,53.27380725850113,0.0,14.0,0.0,1.0,Kinase activation segment DIYxLG,True,assigned_and_evaluated +2129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic amphipathic helical bundles,False,no_term_above_threshold +2130,72011,19.663244,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.94628906,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,9.0,9.0,590.3069306930694,2.4389677268048844e-25,ANL adenylation domain,True,assigned_too_few_test_positives +2131,49116,19.30049,0.80371094,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.80371094,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.7877442273534637,0.3107221976074436,0.002215330084182543,0.4,140.26000000000005,0.0,19.0,0.0,1.0,CID/VHS CTD-binding helix,True,assigned_and_evaluated +2132,37071,16.378796,0.984375,Homeodomain,interpro,87384,DNA-binding,0.7133789,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,2.0,17.0,24.270710360268673,0.00525024086666359,Basic nucleic-acid recognition helices,True,assigned_too_few_test_positives +2133,85664,24.255856,0.9902344,Glycogen Phosphorylase B;,gene3d,38317,Pentatricopeptide repeat,0.90234375,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase donor binding motif,True,assigned_too_few_test_positives +2134,36091,18.71748,0.98828125,GNAT domain,interpro,85712,3.40.630.30,0.9736328,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,7.0,16.0,165.08979430379748,2.078223730144998e-14,GAF/GNAT glycine-loop motif,True,assigned_too_few_test_positives +2135,85649,36.876163,0.9794922,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9765625,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8859814721108559,0.7093638668497606,0.0101905183872397,0.7391304347826086,69.61018467303954,17.0,19.0,98.9705106923152,1.0434836480607708e-32,SAM-binding aromatic–acidic strip,True,assigned_and_evaluated +2136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cobalamin-binding glycine-rich loops,False,no_term_above_threshold +2137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic beta-strand loop motifs,False,no_term_above_threshold +2138,88058,24.347824,0.6044922,Signal,keyword,88058,Signal,0.6044922,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6076659266377283,0.20614852706603615,0.09127159946832078,0.1407766990291262,2.258627308679823,11.0,17.0,4.662029500622001,3.828854493272791e-06,Extracellular beta-sandwich ectodomains,True,assigned_and_evaluated +2139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global helicase activation marker,False,no_term_above_threshold +2140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended noncatalytic scaffold regions,False,no_term_above_threshold +2141,66234,21.286787,0.90625,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.90625,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,12.0,12.0,236.59126984126982,8.789494961737458e-29,Papain-like cysteine protease signature,True,assigned_too_few_test_positives +2142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RS/acidic low-complexity IDRs,False,no_term_above_threshold +2143,87326,30.991323,0.703125,Coiled coil,keyword,87326,Coiled coil,0.703125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6949526307060824,0.18508412307588645,0.03943287549844927,0.0898876404494382,4.693650177328941,17.0,19.0,11.28041980612347,6.733872062658451e-17,Coiled-coil rod scaffolds,True,assigned_and_evaluated +2144,63960,15.753977,0.8769531,FAD/NAD(P)-binding domain superfamily,interpro,87601,Hydrolase,0.6176758,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,14.0,0.0,1.0,Divalent metal hydrolase active-site loops,True,assigned_too_few_test_positives +2145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-boundary capping motifs,False,no_term_above_threshold +2146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-end processing signature,False,no_term_above_threshold +2147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF CAxWMP activation hotspot,False,no_term_above_threshold +2148,43624,17.514345,0.8496094,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.8496094,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.9033773984828202,0.06164620201947171,0.007089056269384138,,8.69596737237173,1.0,14.0,6.271933515674311,0.23574817717128824,Short N-terminal juxtamembrane motifs,True,assigned_and_evaluated +2149,52236,26.22369,0.91015625,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8305664,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,2.0,13.0,34.353788533563815,0.002632827484317634,Alpha-solenoid/TPR hydrophobic helix faces,True,assigned_too_few_test_positives +2150,59224,16.49471,0.6489258,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.6489258,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.5638095238095238,0.013647407090030043,0.0031014621178555605,,4.400313971742544,12.0,15.0,109.90046082949308,2.426589410653379e-23,Alpha/beta-hydrolase fold enzymes,True,assigned_and_evaluated +2151,35372,18.071697,0.9555664,ABC-type transporter activity,go_mf,37097,Cro/C1-type helix-turn-helix domain,0.93310547,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,10.0,19.0,369.1702786377709,5.382850492603729e-24,"ABC TM helices, helicase CTD",True,assigned_too_few_test_positives +2152,50806,24.740667,0.9897461,"Homeobox, conserved site",interpro,64146,Winged helix-like DNA-binding domain superfamily,0.83447266,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,DNA-binding recognition helix,True,assigned_too_few_test_positives +2153,36354,17.925383,0.99316406,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9926758,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,3.0,18.0,35.74400479616307,0.00014202793758327607,Short acidic hydrophobic motif,True,assigned_too_few_test_positives +2154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-propellers and double jelly-rolls,False,no_term_above_threshold +2155,37071,16.765165,0.9790039,Homeodomain,interpro,63831,F-box-like domain superfamily,0.9746094,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,8.0,13.0,126.95448496140538,8.281139495734246e-16,Proline-kinked helix-turn-helix,True,assigned_too_few_test_positives +2156,88058,20.196276,0.6098633,Signal,keyword,88058,Signal,0.6098633,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5974270187878988,0.10112192884983986,0.09127159946832078,,1.10792326900043,2.0,19.0,0.7584162823978374,1.0,N-terminal maturation-junction detector,True,assigned_and_evaluated +2157,37282,20.89247,0.9873047,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.90625,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,12.0,13.0,206.1227312013829,2.1720888772132204e-27,Asn ladder in LRR repeats,True,assigned_too_few_test_positives +2158,87276,25.65117,0.6069336,Cell membrane,keyword,25079,plasma membrane,0.60302734,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6350391057901991,0.250281258952768,0.11120957022596367,0.2948207171314741,2.2505370575952086,8.0,14.0,4.68884432385671,0.0001343282075018867,Cytosolic membrane interfacial helices,True,assigned_and_evaluated +2159,49230,20.983927,0.9609375,Acyl-CoA N-acyltransferase,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8881836,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,16.0,0.0,1.0,CBS-enriched hydrophobic beta-strand motif,True,assigned_too_few_test_positives +2160,37430,18.27973,1.0,"Signal transduction response regulator, receiver domain",interpro,85669,3.40.50.2300,0.9296875,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,14.0,14.0,484.7235772357723,7.836327138722209e-38,REC/HK/c-di-GMP motif detector,True,assigned_too_few_test_positives +2161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RnfC EDNK/YPxGxxK motif detector,False,no_term_above_threshold +2162,27936,20.789223,0.83935547,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.83935547,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,11.0,11.0,641.0860215053764,2.936451144967634e-31,Conserved PPIase chaperone core,True,assigned_too_few_test_positives +2163,37894,25.002241,0.9160156,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9160156,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,14.0,0.0,1.0,Regulatory appendages and motifs,True,assigned_too_few_test_positives +2164,81685,15.80001,0.94970703,Transferase(Phosphotransferase) domain 1,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.87402344,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9819599109131403,0.5464150726593519,0.005316792202038104,0.8333333333333334,102.77156824934642,14.0,14.0,85.66235632183908,2.52616524771724e-27,Conserved protein kinase catalytic core,True,assigned_and_evaluated +2165,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal glycan-assembly TM bundle,False,no_term_above_threshold +2166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich nucleotide-binding loops,False,no_term_above_threshold +2167,46078,19.14378,0.95458984,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.94970703,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,10.0,17.0,76.91047471620227,2.813912293437499e-17,Extended non-transmembrane regional activation,True,assigned_too_few_test_positives +2168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended non-globular low-complexity regions,False,no_term_above_threshold +2169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosyltransferase catalytic-region motif,False,no_term_above_threshold +2170,64146,15.957729,0.77441406,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.77441406,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8265222569599525,0.031351948476976234,0.007975188303057155,,3.9311859840297423,0.0,17.0,0.0,1.0,Single residue motif peak detector,True,assigned_and_evaluated +2171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-propeller blade-edge motifs,False,no_term_above_threshold +2172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM cytosolic linkers,False,no_term_above_threshold +2173,49045,17.277782,0.99609375,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9453125,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,6.0,19.0,171.1607655502392,2.013236497572733e-12,Recurring beta-propeller blade segments,True,assigned_too_few_test_positives +2174,28025,16.15187,0.87402344,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6538086,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9129275877387828,0.287413965487736,0.002658396101019052,,108.11555335097002,5.0,16.0,84.68892045454545,5.629396499240045e-09,GTPase G4/G5 coupling helix,True,assigned_and_evaluated +2175,48880,19.517628,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48883,Pyridoxal phosphate-dependent transferase,1.0,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,17.0,17.0,484.7235772357723,1.7310182502290982e-45,Fold-I PLP catalytic core,True,assigned_too_few_test_positives +2176,50806,22.387234,0.9116211,"Homeobox, conserved site",interpro,37071,Homeodomain,0.8959961,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,PDZ carboxylate-binding loops,True,assigned_too_few_test_positives +2177,47529,23.732967,0.96240234,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.96240234,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9922746541722446,0.3738203592320805,0.007089056269384138,0.6875,52.73203442417536,2.0,19.0,8.13994129292102,0.04133969154815049,Extracytoplasmic beta-sandwich loops,True,assigned_and_evaluated +2178,64317,16.146408,0.9169922,"Knottin, scorpion toxin-like superfamily",interpro,50806,"Homeobox, conserved site",0.82128906,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,18.0,0.0,1.0,Extracellular disulfide-rich domains,True,assigned_too_few_test_positives +2179,82597,17.720154,0.8466797,Tetratricopeptide repeat domain,gene3d,82597,Tetratricopeptide repeat domain,0.8466797,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.7959515974221856,0.020039879890330015,0.0057598582188746125,,3.479231454805757,3.0,20.0,14.61299019607843,0.0018881049809368292,WD-repeat/kinase/P-loop motif detector,True,assigned_and_evaluated +2180,85791,16.72994,0.9550781,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.95458984,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,17.0,0.0,1.0,TDG/DG strand-end beta-turn,True,assigned_too_few_test_positives +2181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-catalytic helical cap,False,no_term_above_threshold +2182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich disordered tails,False,no_term_above_threshold +2183,64058,16.18452,0.8676758,NAD(P)-binding domain superfamily,interpro,88153,Transferase,0.6582031,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9622476275396471,0.24257884159452842,0.006202924235711121,0.42857142857142855,39.10717467706076,0.0,12.0,0.0,1.0,Gly/Ser/Thr-rich phosphate-binding loops,True,assigned_and_evaluated +2184,85675,19.173035,0.94970703,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9272461,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,15.0,19.0,431.8276195074843,7.982792566686333e-38,VWA A-domain fold detector,True,assigned_too_few_test_positives +2185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tracts,False,no_term_above_threshold +2186,29104,16.319403,0.7080078,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.68115234,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,14.0,0.0,1.0,TM helix-loop-helix module,True,assigned_too_few_test_positives +2187,87697,16.141708,0.78515625,Knottin,keyword,87697,Knottin,0.78515625,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7928891817530231,0.0389404351012841,0.017279574656623838,,2.253552872399954,0.0,20.0,0.0,1.0,Low-complexity interaction motifs,True,assigned_and_evaluated +2188,46078,18.216957,0.9741211,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9741211,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,17.0,17.0,130.74780701754386,4.3804222027563406e-36,HEAT/ARM alpha-solenoid scaffolds,True,assigned_too_few_test_positives +2189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Small, globally activated proteins",False,no_term_above_threshold +2190,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic C-terminal patch detector,False,no_term_above_threshold +2191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain core detector,False,no_term_above_threshold +2192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble polar secondary structure,False,no_term_above_threshold +2193,87970,15.593892,0.7729492,Protein phosphatase,keyword,87970,Protein phosphatase,0.7729492,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,14.0,15.0,268.82254428341383,1.653992211698037e-33,PTP-fold phosphatase catalytic domain,True,assigned_too_few_test_positives +2194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic pocket hotspots,False,no_term_above_threshold +2195,37894,23.06188,0.8774414,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.70458984,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,10.0,638.7964285714286,4.250327627086626e-25,SDR active-site lid loop,True,assigned_too_few_test_positives +2196,87586,17.978941,0.7026367,Host membrane,keyword,88161,Transmembrane helix,0.68896484,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.6753226199172147,0.07375838701424312,0.01639344262295082,0.02702702702702703,4.49926160786883,6.0,20.0,19.378439869989165,8.460511364827909e-07,Aromatic interfacial hairpin junction,True,assigned_and_evaluated +2197,64085,23.522106,0.8540039,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.84765625,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9676905082355958,0.2847023933883135,0.012405848471422242,,22.94904649562227,3.0,19.0,18.56773590781688,0.000949257543208473,Beta-propeller and pinwheel folds,True,assigned_and_evaluated +2198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TM1 signal anchor,False,no_term_above_threshold +2199,37020,15.872412,0.94677734,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.8334961,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,11.0,0.0,1.0,ABC NBD pre-P-loop beta-strand,True,assigned_too_few_test_positives +2200,85675,22.758266,0.95214844,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.93066406,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,18.0,18.0,546.9816513761467,7.774077354345683e-49,VWA/integrin I MIDAS domain,True,assigned_too_few_test_positives +2201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Receptor-binding β-solenoid shafts,False,no_term_above_threshold +2202,36535,23.441664,0.9682617,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9042969,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9490209167779261,0.8904430660168364,0.004430660168365086,0.9,200.97299999999998,12.0,12.0,89.79066265060241,9.608590434204234e-24,Kinase N-lobe loop signature,True,assigned_and_evaluated +2203,85682,26.465889,0.7265625,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7265625,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8521594982078854,0.23521119200950572,0.011076650420912717,,21.234866414618175,17.0,17.0,102.26586620926243,2.6394552661124587e-34,Rossmann dehydrogenase helical scaffold,True,assigned_and_evaluated +2204,37894,16.814037,0.79345703,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.79345703,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,18.0,0.0,1.0,Nucleotidyltransferase N-terminal NTP-binding loop,True,assigned_too_few_test_positives +2205,80926,18.334,0.8598633,Homeodomain-like,gene3d,87384,DNA-binding,0.64404297,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.9125188536953244,0.13704816564389374,0.0057598582188746125,,23.793669989097552,1.0,19.0,5.020715789473684,0.2873479223675574,Basic phosphate-binding residues,True,assigned_and_evaluated +2206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH81 glucanase catalytic core,False,no_term_above_threshold +2207,85672,16.516161,0.7163086,P-loop containing nucleotide triphosphate hydrolases,gene3d,87601,Hydrolase,0.61865234,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8088261043573965,0.06353761704166544,0.01595037660611431,,3.9834556017510807,0.0,16.0,0.0,1.0,Active-site pocket loops,True,assigned_and_evaluated +2208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich active-site cradle,False,no_term_above_threshold +2209,59224,16.749403,0.9301758,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.80126953,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9356825396825398,0.04035724152831476,0.0031014621178555605,,13.012327732772345,0.0,11.0,0.0,1.0,Active site gating loops,True,assigned_and_evaluated +2210,59229,26.820248,0.9707031,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9707031,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9684227939745436,0.6782595937917947,0.0101905183872397,0.6956521739130435,66.55790883426437,9.0,19.0,50.3414016324233,1.0469669746645231e-13,Cofactor-adjacent short helix,True,assigned_and_evaluated +2211,64003,26.72424,0.9921875,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.8120117,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9997528667457495,0.9376903960237295,0.003987594151528578,1.0,235.1519137583953,1.0,19.0,6.866405620177358,0.21710244354744598,Zinc finger helix-linker boundary,True,assigned_and_evaluated +2212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histone-fold HLH hairpin detector,False,no_term_above_threshold +2213,31094,16.566355,0.91308594,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.7871094,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.7970627503337784,0.27600411065213376,0.004430660168365086,0.4,62.29412777418659,0.0,19.0,0.0,1.0,Flexible loops and disordered domains,True,assigned_and_evaluated +2214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Auxiliary cluster DxxGD[V/I] hydrophobe,False,no_term_above_threshold +2215,36876,18.882196,0.9995117,Cytochrome P450,interpro,36876,Cytochrome P450,0.9995117,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,389.6797385620915,2.4234264751426887e-46,P450 heme-proximal DPxxFG motif,True,assigned_and_evaluated +2216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp ATP-binding activation,False,no_term_above_threshold +2217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic intrinsically disordered tails,False,no_term_above_threshold +2218,47529,18.210314,0.7885742,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7885742,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.794692659526997,0.34720754613797394,0.007089056269384138,0.4375,48.97796447708795,2.0,15.0,10.310592304366624,0.026526517639821317,ILV-rich beta-strand cores,True,assigned_and_evaluated +2219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic helices,False,no_term_above_threshold +2220,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BED-transposase core activation,False,no_term_above_threshold +2221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Autoinhibitory protease propeptides,False,no_term_above_threshold +2222,85672,16.63213,0.68603516,P-loop containing nucleotide triphosphate hydrolases,gene3d,87601,Hydrolase,0.60009766,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8153797088398619,0.12459165599033205,0.01595037660611431,0.08333333333333333,7.811204654727207,0.0,15.0,0.0,1.0,Glycine-centered active-site loops,True,assigned_and_evaluated +2223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sheet edge loop connectors,False,no_term_above_threshold +2224,46581,16.372532,0.97998047,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.97998047,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,1.0,17.0,10.195109439124487,0.15183816635375263,Alpha-helix N-cap preference,True,assigned_too_few_test_positives +2225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail and ER anchor,False,no_term_above_threshold +2226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short conserved loop motifs,False,no_term_above_threshold +2227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1 loop TM2 hairpin motif,False,no_term_above_threshold +2228,88160,15.92729,0.86376953,Transmembrane beta strand,keyword,25167,cell outer membrane,0.72265625,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,15.0,17.0,255.37264420331238,4.974412382902556e-35,OMP barrel-strand initiation signature,True,assigned_too_few_test_positives +2229,87523,17.53647,0.60791016,Glycosidase,keyword,87523,Glycosidase,0.60791016,108,keywords,Glycosidase,keyword:keywords:Glycosidase,8.0,2257.0,0.5559415295686972,0.009053843070236513,0.003544528134692069,,2.5543154761904763,13.0,15.0,97.49345911949685,5.826703083068229e-25,N-terminal CAZyme accessory module,True,assigned_and_evaluated +2230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SF1 helicase 2A subdomain,False,no_term_above_threshold +2231,50338,18.011414,0.9135742,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.81152344,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Membrane lipid-modifying catalytic core,True,assigned_too_few_test_positives +2232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted beta-strand motifs,False,no_term_above_threshold +2233,72011,16.08529,0.9975586,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.98291016,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,19.0,0.0,1.0,Non-catalytic assembly and binding regions,True,assigned_too_few_test_positives +2234,87873,18.850529,0.6401367,Oxidoreductase,keyword,87873,Oxidoreductase,0.6401367,537,keywords,Oxidoreductase,keyword:keywords:Oxidoreductase,48.0,2257.0,0.7212869699713294,0.07528076031952124,0.021267168808152416,,3.539764084190822,1.0,19.0,1.3234699993340584,0.8332761974300508,Eukaryotic N-terminal targeting signals,True,assigned_and_evaluated +2235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic adjacent helix loop motif,False,no_term_above_threshold +2236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBP60 and receptor extracellular,False,no_term_above_threshold +2237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting presequences,False,no_term_above_threshold +2238,58239,30.22262,0.7324219,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7324219,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6389264772214706,0.14825485326779544,0.017722640673460344,0.1,8.365280095635358,18.0,18.0,35.851473241130485,3.2784535000502832e-28,SF2 two-lobed helicase core,True,assigned_and_evaluated +2239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent OM beta-barrel transporters,False,no_term_above_threshold +2240,88161,48.74129,0.63623047,Transmembrane helix,keyword,88161,Transmembrane helix,0.63623047,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5993587738504847,0.3293612231825188,0.1847585290208241,0.24700239808153476,1.7826577475370384,19.0,19.0,5.4274920345926265,2.5090631899926267e-14,N-terminal juxtamembrane amphipathic helix,True,assigned_and_evaluated +2241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β-α segment activation,False,no_term_above_threshold +2242,87522,24.332445,0.64990234,Glycoprotein,keyword,88159,Transmembrane,0.62890625,1135,keywords,Glycoprotein,keyword:keywords:Glycoprotein,89.0,2257.0,0.7490178904598035,0.27258975299013977,0.03943287549844927,0.12359550561797752,6.91275362358141,3.0,15.0,2.0915979652692513,0.2655872205137073,Cytosolic juxtamembrane disordered tails,True,assigned_and_evaluated +2243,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered Gly/Pro-rich repeats,False,no_term_above_threshold +2244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal pocket-capping helices,False,no_term_above_threshold +2245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fe–S and radical SAM enzymes,False,no_term_above_threshold +2246,85649,23.693748,0.94189453,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.93896484,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9490774979564829,0.19653671830689812,0.0101905183872397,,19.286233618203,0.0,14.0,0.0,1.0,N-terminal Rossmann helix segment,True,assigned_and_evaluated +2247,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide binding catalytic core,False,no_term_above_threshold +2248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HAMP signal relay module,False,no_term_above_threshold +2249,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active-site loop motifs,False,no_term_above_threshold +2250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed extracytoplasmic loops,False,no_term_above_threshold +2251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic transporter C-terminal helices,False,no_term_above_threshold +2252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAA C-terminal propeptide motif,False,no_term_above_threshold +2253,28225,16.577715,0.8461914,metalloendopeptidase activity,go_mf,28225,metalloendopeptidase activity,0.8461914,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,11.0,17.0,196.828031212485,1.2842289303940877e-23,Metalloprotease pre-HExxH scaffold,True,assigned_too_few_test_positives +2254,36914,21.724413,0.9423828,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8823242,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Glycosyltransferase donor-binding acidic loop,True,assigned_too_few_test_positives +2255,37341,16.216736,0.9291992,WD40 repeat,interpro,87697,Knottin,0.8305664,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9841305430991529,0.2895990701486111,0.011962782454585734,,24.208337086126487,0.0,16.0,0.0,1.0,Conserved pocket-lining beta strands,True,assigned_and_evaluated +2256,64148,31.512802,0.796875,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.796875,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.7805841681952872,0.3404581133454909,0.008418254319893664,0.2631578947368421,40.442840095830164,14.0,14.0,88.9865671641791,1.4958294825485371e-27,Bacterial HTH recognition helix,True,assigned_and_evaluated +2257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic low-complexity IDRs,False,no_term_above_threshold +2258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed interface loop/linker segments,False,no_term_above_threshold +2259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site nucleotide-binding alpha/beta segments,False,no_term_above_threshold +2260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix initiation motif detector,False,no_term_above_threshold +2261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain boundary helical cap,False,no_term_above_threshold +2262,87239,16.321709,0.7475586,CF(1),keyword,87239,CF(1),0.7475586,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.8721949038891371,0.44457879221544655,0.008861320336730172,0.75,50.17071670151314,0.0,16.0,0.0,1.0,Secondary-structure cap/hinge motif,True,assigned_and_evaluated +2263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich anion-binding loops,False,no_term_above_threshold +2264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking loop motif,False,no_term_above_threshold +2265,88009,15.768667,0.61279297,Repeat,keyword,88009,Repeat,0.61279297,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6663471735051799,0.11548808477172956,0.07266282676118742,,1.5893695568889854,0.0,17.0,0.0,1.0,Helix C-terminal capping motif,True,assigned_and_evaluated +2266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal boundary linkers,False,no_term_above_threshold +2267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered proline/glycine-rich repeats,False,no_term_above_threshold +2268,88160,17.65366,0.87353516,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.87353516,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,11.0,16.0,198.97785194174756,8.051316406089079e-24,Outer-membrane beta-barrel strands,True,assigned_too_few_test_positives +2269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural boundary hinge residues,False,no_term_above_threshold +2270,87149,20.872929,0.6323242,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6323242,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7176824969557137,0.08645106530300092,0.012405848471422242,,6.968573371031182,0.0,15.0,0.0,1.0,Short Gly/Ala-rich hydrophobic helices,True,assigned_and_evaluated +2271,36010,19.064014,0.9760742,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.8183594,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,5.0,13.0,195.99276791584487,7.220762060289025e-11,Substrate-gating cap/lid loops,True,assigned_too_few_test_positives +2272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic partner-binding patches,False,no_term_above_threshold +2273,59237,15.627697,0.9970703,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.9970703,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,2.0,18.0,34.86608187134503,0.002609095519735958,[S/A]LA[S/F]YGV motif,True,assigned_too_few_test_positives +2274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +2275,83267,16.013895,0.9682617,DNA-binding pseudobarrel domain,gene3d,48767,DNA-binding pseudobarrel domain superfamily,0.9658203,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,18.0,0.0,1.0,C-terminal effector modules,True,assigned_too_few_test_positives +2276,47529,23.253447,0.86865234,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.86865234,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8533299866131191,0.17842332308719627,0.007089056269384138,0.0625,25.168840012987626,7.0,19.0,28.489794525223566,5.283737104858649e-09,Surface acidic/proline beta-edge motifs,True,assigned_and_evaluated +2277,72011,16.844873,0.8666992,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.8286133,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,Substrate-binding active-site patch,True,assigned_too_few_test_positives +2278,59229,21.27308,0.6669922,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6669922,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.649429761395041,0.2933209403273551,0.0101905183872397,0.30434782608695654,28.783711405166976,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM-dependent DNA MTase core,True,assigned_and_evaluated +2279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic cores and TM bundles,False,no_term_above_threshold +2280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed non-TM membrane helices/loops,False,no_term_above_threshold +2281,85649,16.992338,0.63623047,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.63623047,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6025845626873225,0.11590622278581578,0.0101905183872397,0.08695652173913043,11.373928035982008,15.0,16.0,103.70071892393321,1.0701690889352076e-29,C-terminal substrate-recognition tail,True,assigned_and_evaluated +2282,25167,16.96172,0.6323242,cell outer membrane,go_cc,25167,cell outer membrane,0.6323242,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7897550111358576,0.412831912575765,0.005316792202038104,0.5,77.64680222362513,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer membrane beta barrel wall,True,assigned_and_evaluated +2283,88058,27.406054,0.6123047,Signal,keyword,88058,Signal,0.6123047,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5976944706110682,0.1569028197816241,0.09127159946832078,0.009708737864077669,1.7190760400345901,14.0,14.0,7.204954682779456,2.1453129052877637e-12,Aromatic-acidic cleft-flanking loops,True,assigned_and_evaluated +2284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich structural scaffold,False,no_term_above_threshold +2285,43624,19.956505,0.67089844,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.67089844,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8014837126282909,0.16579875409864617,0.007089056269384138,,23.387986750040277,0.0,10.0,0.0,1.0,Hydrophobic helix recognition face,True,assigned_and_evaluated +2286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved noncatalytic helix C-cap motif,False,no_term_above_threshold +2287,87149,21.292395,0.6772461,Amphibian defense peptide,keyword,87162,Antimicrobial,0.625,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7184035121451003,0.15868000485094283,0.012405848471422242,,12.79074181959207,3.0,18.0,25.28456318914334,0.0003884443117578521,Polybasic disordered propeptides/tails,True,assigned_and_evaluated +2288,36886,20.105295,1.0,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,29166,zinc ion binding,0.77734375,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9997220987105381,0.9067956349206349,0.003544528134692069,1.0,255.8297185019841,18.0,19.0,221.5021671826625,2.4241042625813076e-41,Zinc-finger inter-cysteine spacers,True,assigned_and_evaluated +2289,63892,16.19913,0.85253906,Fibronectin type III superfamily,interpro,63892,Fibronectin type III superfamily,0.85253906,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,3.0,17.0,51.07452884066248,4.935853125375923e-05,Catalytic beta-strands and FN3,True,assigned_too_few_test_positives +2290,85682,16.516844,0.7963867,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.68603516,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.926836917562724,0.11170686398301953,0.011076650420912717,0.04,10.084895680387003,2.0,10.0,20.453173241852486,0.007027709425711204,Pyruvate kinase active-site motifs,True,assigned_and_evaluated +2291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NLR CC N-terminal loop segments,False,no_term_above_threshold +2292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial regulatory hydrophobic cores,False,no_term_above_threshold +2293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hybrid histidine kinase REC activator,False,no_term_above_threshold +2294,50806,17.033588,0.9897461,"Homeobox, conserved site",interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9580078,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,HTH recognition-helix hydrophobic residue,True,assigned_too_few_test_positives +2295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site phosphate-binding loop,False,no_term_above_threshold +2296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GATase-2 internal helix-strand-helix,False,no_term_above_threshold +2297,37341,22.381681,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9873047,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD-repeat blade-loop signature,True,assigned_and_evaluated +2298,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Thioesterase chain-wide activation, N-termini/PTS1",False,no_term_above_threshold +2299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulator sensor domains,False,no_term_above_threshold +2300,88009,19.893742,0.6435547,Repeat,keyword,88009,Repeat,0.6435547,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6517063265472597,0.17441090279565097,0.07266282676118742,0.006097560975609756,2.400276875669416,11.0,19.0,5.132702015261201,2.270632830523537e-06,Low-complexity tandem repeat sensor,True,assigned_and_evaluated +2301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity flexible tails/linkers,False,no_term_above_threshold +2302,25169,16.31427,0.7324219,pilus,go_cc,25169,pilus,0.7324219,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.6783747779751331,0.020140008861320335,0.002215330084182543,,9.0912,0.0,15.0,0.0,1.0,Seipin post-TM lumenal/propeptide detector,True,assigned_and_evaluated +2303,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity transactivation IDRs,False,no_term_above_threshold +2304,88161,26.550182,0.6357422,Transmembrane helix,keyword,88161,Transmembrane helix,0.6357422,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6580446512355334,0.30508298276183,0.1847585290208241,0.12470023980815348,1.6512524990250608,8.0,14.0,3.101424019767215,0.0023974917011427357,Transmembrane helices and interfaces,True,assigned_and_evaluated +2305,58239,21.077688,0.74560547,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.74560547,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7937584573748309,0.06425368895917036,0.017722640673460344,,3.6255143995211876,0.0,13.0,0.0,1.0,Basic phosphate-binding loops,True,assigned_and_evaluated +2306,86130,27.142385,0.9550781,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9501953,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.997968253968254,0.48283621140763994,0.0031014621178555605,0.5714285714285714,155.68018987814904,0.0,15.0,0.0,1.0,Broad C-terminal ABH cap activation,True,assigned_and_evaluated +2307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter NBD C-terminal loop,False,no_term_above_threshold +2308,88164,20.207321,0.90283203,Transposition,keyword,88163,Transposable element,0.7285156,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.6837033747779752,0.06214000886132034,0.002215330084182543,,28.050000000000004,2.0,13.0,111.85928705440901,0.00026194971325511673,RNase H-like DDE nuclease core,True,assigned_and_evaluated +2309,4066,19.802355,0.8408203,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.8408203,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.591740674955595,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,0.0,19.0,0.0,1.0,Low-complexity disordered regions,True,assigned_and_evaluated +2310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide/phosphate-binding catalytic cores,False,no_term_above_threshold +2311,31094,16.113691,0.96533203,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.83154297,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9991099243435692,0.8973684210526315,0.004430660168365086,1.0,202.53605263157894,0.0,15.0,0.0,1.0,Nucleotide-binding glycine-rich loop,True,assigned_and_evaluated +2312,47529,17.692503,0.64746094,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.64746094,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6194779116465864,0.16885845886870476,0.007089056269384138,0.1875,23.819596354166666,13.0,17.0,59.13427939269093,1.570587248850288e-21,Nitrate reductase hinge; S/T-rich linkers,True,assigned_and_evaluated +2313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal metabolite-kinase motif,False,no_term_above_threshold +2314,48883,17.253616,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,Conserved AAT-like C-terminal loop,True,assigned_too_few_test_positives +2315,50763,19.755737,0.97509766,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.9536133,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,18.0,18.0,304.1887755102041,1.7201332308791941e-44,RING/B-box linker recognizer,True,assigned_too_few_test_positives +2316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glutamate mutase cobalamin helix,False,no_term_above_threshold +2317,49116,22.51479,0.9536133,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9536133,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9972468916518651,0.5019198193111236,0.002215330084182543,0.4,226.56660643704123,14.0,20.0,60.926569343065694,6.288806491154213e-23,HEAT/ARM and coiled-coil linkers,True,assigned_and_evaluated +2318,64058,16.671465,0.7397461,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7290039,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8081969301318388,0.030922356942144458,0.006202924235711121,,4.985125687030003,0.0,16.0,0.0,1.0,Short N-terminal amphipathic segment,True,assigned_and_evaluated +2319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Threonine residue detector,False,no_term_above_threshold +2320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic ion binding catalytic cores,False,no_term_above_threshold +2321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic metallo-phospho/sulfohydrolase motif,False,no_term_above_threshold +2322,87158,16.467588,0.62890625,Antibiotic,keyword,87158,Antibiotic,0.62890625,472,keywords,Antibiotic,keyword:keywords:Antibiotic,43.0,2257.0,0.6721865086867923,0.05560361277065983,0.01905183872396987,,2.918543116822773,2.0,13.0,10.945658160455297,0.023555886636814904,Terminal amphipathic targeting segments,True,assigned_and_evaluated +2323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH N-terminal subdomain,False,no_term_above_threshold +2324,55054,25.339886,1.0,HAD superfamily,interpro,55054,HAD superfamily,1.0,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8975133214920071,0.5837763993501699,0.002215330084182543,0.8,263.5166666666667,18.0,18.0,334.9494382022472,3.408992422977286e-45,HAD cap/interface substrate β-strand,True,assigned_and_evaluated +2325,52236,20.192787,0.9663086,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.94140625,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,3.0,17.0,39.405816259087906,0.00010586972687427755,Glycine helix–coil linkers,True,assigned_too_few_test_positives +2326,37341,24.316896,0.99609375,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9916992,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999003487792726,0.9920567347131841,0.011962782454585734,1.0,82.92859445361691,17.0,19.0,130.11001283697047,1.0436922722777094e-34,Propeller β-strand interface signal,True,assigned_and_evaluated +2327,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical scaffolds,False,no_term_above_threshold +2328,36886,24.86709,0.9951172,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9951172,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9356380613606047,0.7077843358581064,0.003544528134692069,0.875,199.68365575396828,18.0,18.0,233.80784313725488,1.5159322438572416e-42,Zn2Cys6 AD-like IDRs,True,assigned_and_evaluated +2329,45714,18.883728,0.9873047,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9326172,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,19.0,0.0,1.0,Histidine kinase transmitter/HAMP,True,assigned_too_few_test_positives +2330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-gating cap/lid module,False,no_term_above_threshold +2331,85672,22.489721,0.60498047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6015625,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6752651458302066,0.20102773690828174,0.01595037660611431,0.1388888888888889,12.603322283388664,15.0,16.0,37.513213087248324,3.8324524352784926e-23,Nucleotide phosphate-sensing lid loops,True,assigned_and_evaluated +2332,85649,26.60356,0.9355469,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9296875,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.868358569148729,0.38314240168078234,0.0101905183872397,0.391304347826087,37.597930460588074,16.0,16.0,110.61410018552876,7.117153535323136e-33,Helix-end His/Tyr SAM motif,True,assigned_and_evaluated +2333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse N-terminal and ECL peaks,False,no_term_above_threshold +2334,36010,16.822716,0.9951172,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.94433594,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,13.0,19.0,348.66081871345034,3.4999842859561397e-31,AB-hydrolase C-terminal cap helix,True,assigned_too_few_test_positives +2335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic accessory domain,False,no_term_above_threshold +2336,84152,20.637184,0.87890625,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.87890625,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,18.0,18.0,562.4622641509434,5.407112538669923e-49,C-terminal helical cap motif,True,assigned_too_few_test_positives +2337,36091,16.214834,0.9584961,GNAT domain,interpro,85712,3.40.630.30,0.9550781,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,Catalytic loop-helix junction motif,True,assigned_too_few_test_positives +2338,88058,16.49708,0.6010742,Signal,keyword,88058,Signal,0.6010742,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6082410663990571,0.11367540790239487,0.09127159946832078,,1.2454630856102196,2.0,16.0,0.900619335347432,1.0,YidC DLS-PD TM motif,True,assigned_and_evaluated +2339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MSCRAMM A-domain beta-strands,False,no_term_above_threshold +2340,43643,24.291769,0.9902344,Phosphopantetheine binding ACP domain,interpro,87913,Phosphopantetheine,0.98046875,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,0.9904703139997257,0.23735821277565752,0.0057598582188746125,,41.20903740266608,0.0,15.0,0.0,1.0,Short surface-exposed acidic beta-strand,True,assigned_and_evaluated +2341,81858,16.446285,0.93603516,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.77001953,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Multipass transmembrane helices,True,assigned_too_few_test_positives +2342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich flexible loop boundaries,False,no_term_above_threshold +2343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding loops,False,no_term_above_threshold +2344,87326,37.943123,0.7739258,Coiled coil,keyword,87326,Coiled coil,0.7739258,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7832725237364733,0.23955356628210803,0.03943287549844927,0.1348314606741573,6.074970776390088,8.0,16.0,6.303764009304293,2.087797279889246e-05,Coiled-coil helices and boundaries,True,assigned_and_evaluated +2345,37446,21.446861,0.8989258,F-box domain,interpro,37446,F-box domain,0.8989258,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9603174603174603,0.09830400169546391,0.0031014621178555605,,31.696018832380293,0.0,15.0,0.0,1.0,N-terminal linker segments,True,assigned_and_evaluated +2346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Golgi sulfotransferase N-glycosylation sequon,False,no_term_above_threshold +2347,37894,20.912981,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.92529297,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,15.0,15.0,709.7738095238095,6.148192482588648e-43,Rossmann NAD(P)H-binding loop,True,assigned_too_few_test_positives +2348,45804,25.393215,0.9941406,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.97753906,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,18.0,20.0,248.42083333333332,1.1297475668278472e-41,MFS periplasmic helix–loop junctions,True,assigned_too_few_test_positives +2349,61392,25.01437,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,17.0,17.0,167.4747191011236,7.122304359043567e-38,LRR Asn-ladder turn motif,True,assigned_and_evaluated +2350,50338,21.959515,0.97558594,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.92089844,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Extracellular/lumenal loops and helix termini,True,assigned_too_few_test_positives +2351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal acidic S/T-rich IDR tails,False,no_term_above_threshold +2352,87326,37.742958,0.7114258,Coiled coil,keyword,87326,Coiled coil,0.7114258,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7449754343049049,0.20187751003963023,0.03943287549844927,,5.1195229231398365,7.0,14.0,6.303764009304293,7.528083055654383e-05,Charged amphipathic recognition helices,True,assigned_and_evaluated +2353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyl cyclase active-site detector,False,no_term_above_threshold +2354,85762,29.682192,0.8623047,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.8544922,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,13.0,13.0,205.58965517241379,2.4985932607894418e-30,N-terminal FAD-anchoring helix,True,assigned_too_few_test_positives +2355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic glycan-binding scaffolds,False,no_term_above_threshold +2356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic mid-domain scaffold,False,no_term_above_threshold +2357,27918,16.620317,0.60839844,DNA-binding transcription factor activity,go_mf,27918,DNA-binding transcription factor activity,0.60839844,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.6313996081437941,0.12284496984438435,0.00930438635356668,0.23809523809523808,13.202909378036928,7.0,7.0,37.008690254500316,2.2320107305632787e-11,Disordered C-terminal activation tails,True,assigned_and_evaluated +2358,36354,17.51941,0.86328125,RNA recognition motif domain,interpro,63831,F-box-like domain superfamily,0.78125,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,10.0,0.0,1.0,SDR active-site entrance loop,True,assigned_too_few_test_positives +2359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal aromatic anchor interfaces,False,no_term_above_threshold +2360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed binding loops,False,no_term_above_threshold +2361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH5 mannanase cleft-loop hotspot,False,no_term_above_threshold +2362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,All-alpha helical scaffold repeats,False,no_term_above_threshold +2363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged alpha-helical tracts,False,no_term_above_threshold +2364,36914,17.687023,0.97998047,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9501953,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,19.0,697.3216374269006,6.312703931151055e-50,Glycosyltransferase donor-sugar/metal loop,True,assigned_too_few_test_positives +2365,30398,15.994746,0.7104492,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.62597656,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6177851534040314,0.20484322943339336,0.004873726185201595,0.18181818181818182,42.03010625737899,6.0,6.0,72.00603864734299,1.5227371311623493e-11,ABC NBD switch loops,True,assigned_and_evaluated +2366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended hydrophobic segment detector,False,no_term_above_threshold +2367,36010,18.480175,0.9980469,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.89453125,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,18.0,19.0,482.7611336032389,3.1113490681660496e-47,Alpha/beta-hydrolase cap/lid subdomain,True,assigned_too_few_test_positives +2368,36115,21.253098,0.8745117,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8696289,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,18.0,0.0,1.0,Loop-to-TM interface helices,True,assigned_too_few_test_positives +2369,87326,21.17572,0.65771484,Coiled coil,keyword,87326,Coiled coil,0.65771484,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7091478709730917,0.11360297878061903,0.03943287549844927,0.011235955056179775,2.880920484357946,9.0,17.0,6.674573656910428,3.1772786071036616e-06,Non-transmembrane amphipathic helices,True,assigned_and_evaluated +2370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar hotspots in structured segments,False,no_term_above_threshold +2371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S8 protease C-terminal activation,False,no_term_above_threshold +2372,4066,15.78572,0.76708984,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.76708984,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.8955150976909414,0.3225209880947586,0.002215330084182543,0.4,145.58597402597405,5.0,20.0,179.58132530120483,1.4885034776060553e-10,Internal partner-binding segments,True,assigned_and_evaluated +2373,82029,24.273209,0.99902344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.62939453,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS transporter TM helices,True,assigned_too_few_test_positives +2374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-Gly/Cys low-complexity motifs,False,no_term_above_threshold +2375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic glycoprotein ectodomains,False,no_term_above_threshold +2376,87276,44.932587,0.7290039,Cell membrane,keyword,88161,Transmembrane helix,0.7109375,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7707326228485857,0.49827627358601556,0.11120957022596367,0.5856573705179283,4.480516133400944,17.0,19.0,7.341743086038797,8.654145245761993e-14,TM helix-to-loop interface,True,assigned_and_evaluated +2377,48767,16.063547,0.99121094,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99121094,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,17.0,0.0,1.0,Acidic beta-strand N-cap,True,assigned_too_few_test_positives +2378,85649,31.347649,0.9838867,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98046875,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9501479117200576,0.7853952222778889,0.0101905183872397,0.7391304347826086,77.07117463831284,18.0,18.0,110.61410018552876,7.381758732295342e-37,SAM pocket flanking loops,True,assigned_and_evaluated +2379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal and IDR activation,False,no_term_above_threshold +2380,27013,15.704199,0.78125,side of membrane,go_cc,88058,Signal,0.6201172,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.6222789871168368,0.007023185984934619,0.002658396101019052,,2.6418884613329054,0.0,17.0,0.0,1.0,Ectodomain C-terminal beta-strand linker,True,assigned_and_evaluated +2381,63960,36.651844,0.92822266,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.92822266,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,18.0,18.0,193.57467532467533,4.1657852190163465e-41,Flavoprotein oxidoreductase core motif,True,assigned_too_few_test_positives +2382,52236,19.199156,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99609375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,19.0,19.0,223.29962546816478,2.2408398621355094e-44,TPR repeat boundary loops,True,assigned_too_few_test_positives +2383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme polysaccharide-binding cleft,False,no_term_above_threshold +2384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent pocket,False,no_term_above_threshold +2385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic metal-ligand loop scaffold,False,no_term_above_threshold +2386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic ligand-binding subdomain,False,no_term_above_threshold +2387,63831,21.491108,0.70458984,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.70458984,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.6503776099511327,0.013204614785411038,0.002658396101019052,,4.967135928445452,0.0,16.0,0.0,1.0,PAS-like sensory helix hotspots,True,assigned_and_evaluated +2388,25169,16.317095,0.796875,pilus,go_cc,25169,pilus,0.796875,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.963765541740675,0.034170134004871455,0.002215330084182543,,15.424398489798977,0.0,17.0,0.0,1.0,Extracellular edge beta-strands,True,assigned_and_evaluated +2389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved cofactor-flanking loops,False,no_term_above_threshold +2390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmission coiled-coil linker,False,no_term_above_threshold +2391,49045,16.400543,0.9609375,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.94189453,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,14.0,0.0,1.0,Top-face beta-propeller loops,True,assigned_too_few_test_positives +2392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,charged terminal alpha helix,False,no_term_above_threshold +2393,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich β1–α1 Rossmann motif,False,no_term_above_threshold +2394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TGc pre-catalytic loop,False,no_term_above_threshold +2395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory Q/N-rich IDRs,False,no_term_above_threshold +2396,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracytoplasmic enzyme cores,False,no_term_above_threshold +2397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytochrome N-terminal export signals,False,no_term_above_threshold +2398,49116,18.146263,0.8027344,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8027344,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.7865896980461812,0.2283155991183125,0.002215330084182543,0.2,103.06166144200627,19.0,19.0,87.03795620437957,6.605101239071875e-37,N-terminal ARM/HEAT and coiled-coils,True,assigned_and_evaluated +2399,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active-site region,False,no_term_above_threshold +2400,38317,23.887936,0.9819336,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.8027344,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9992380952380951,0.6679138321995465,0.0031014621178555605,1.0,215.35450275348234,12.0,19.0,242.9378607809847,9.86562392902967e-27,Organelle gene-expression helical scaffold,True,assigned_and_evaluated +2401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity disordered tails,False,no_term_above_threshold +2402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,D2HGDH and Fd-GOGAT conserved motifs,False,no_term_above_threshold +2403,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed low-complexity tandem repeats,False,no_term_above_threshold +2404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic nucleic acid binding stretches,False,no_term_above_threshold +2405,45272,29.327639,0.99902344,"Lambda repressor-like, DNA-binding domain superfamily",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.99902344,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,15.0,19.0,351.2627651217596,1.8623690927061056e-36,HTH/homeodomain recognition helix,True,assigned_too_few_test_positives +2406,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pervasive PLAT and lipoxygenase activation,False,no_term_above_threshold +2407,38317,27.77217,0.9165039,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9165039,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7678095238095238,0.02933001945907422,0.0031014621178555605,,9.456836274161502,0.0,16.0,0.0,1.0,N-terminal capping domain,True,assigned_and_evaluated +2408,12207,15.8917465,0.79296875,transposition,go_bp,88164,Transposition,0.7338867,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,1.0,15.0,86.4072463768116,0.01958947698497016,Broad C-terminal region detector,True,assigned_too_few_test_positives +2409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SIMIBI P-loop ATPase downstream helix,False,no_term_above_threshold +2410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavoprotein FAD-binding core,False,no_term_above_threshold +2411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical catalytic module,False,no_term_above_threshold +2412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal formyltransferase loop hotspot,False,no_term_above_threshold +2413,37894,27.60329,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7402344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,16.0,16.0,709.7738095238095,1.3714649252219745e-45,SDR mid-core substrate-binding loop,True,assigned_too_few_test_positives +2414,47531,16.388554,0.82177734,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.82177734,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,0.0,13.0,0.0,1.0,GH catalytic groove signature,True,assigned_too_few_test_positives +2415,37291,24.037416,0.9165039,DnaJ domain,interpro,81330,DnaJ domain,0.9042969,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,0.0,18.0,0.0,1.0,N-terminal HTH–coiled-coil region,True,assigned_too_few_test_positives +2416,46078,19.866934,0.97216797,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.97216797,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,15.0,19.0,103.22195290858726,1.8580807554441975e-28,Alpha-solenoid helical repeat detector,True,assigned_too_few_test_positives +2417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-kinase phosphate-contact hotspot,False,no_term_above_threshold +2418,59229,20.945995,0.65771484,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.65771484,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.6707018021875365,0.18549974519325907,0.0101905183872397,0.13043478260869565,18.203170647877638,16.0,17.0,100.02474572716787,2.1086661383518e-31,N6-adenine DNA methyltransferase core,True,assigned_and_evaluated +2419,30398,16.99875,0.7089844,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.68652344,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.5857281631992229,0.050819550074393594,0.004873726185201595,,10.427247683446032,17.0,20.0,61.20513285024154,8.732316527659777e-29,NTPase Walker A P-loops,True,assigned_and_evaluated +2420,42974,15.652679,0.9511719,"Serine/threonine-protein kinase, active site",interpro,45290,Protein kinase-like domain superfamily,0.90234375,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9272380952380953,0.7490825217991495,0.0031014621178555605,0.8571428571428571,241.52560738581147,18.0,18.0,133.08258928571428,2.8659952718791303e-38,Kinase P-loop ATP-binding,True,assigned_and_evaluated +2421,59229,35.090717,0.81347656,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.81347656,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7308882488030828,0.12031367592835004,0.0101905183872397,,11.806433329142871,8.0,12.0,70.85086155674391,6.39473994417136e-14,SAM-dependent methyltransferase signature,True,assigned_and_evaluated +2422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PGP synthase ATP-binding motif,False,no_term_above_threshold +2423,38654,15.729216,0.7089844,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.7089844,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,19.0,0.0,1.0,Amphipathic helical dimerization interfaces,True,assigned_too_few_test_positives +2424,64596,18.457428,0.9628906,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,85656,alpha/beta hydrolase,0.7714844,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,0.0,16.0,0.0,1.0,Acidic divalent cation binding motifs,True,assigned_too_few_test_positives +2425,87326,24.309628,0.61328125,Coiled coil,keyword,87326,Coiled coil,0.61328125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.607622621170032,0.1113228013008897,0.03943287549844927,,2.823096208270877,9.0,19.0,5.971986956183014,1.026054543559621e-05,PERQ-rich polyampholytic disordered linkers,True,assigned_and_evaluated +2426,45288,22.981283,0.98339844,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.98339844,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,16.0,16.0,462.17829457364337,1.1105476792425275e-42,REC EAL-like acidic motif,True,assigned_too_few_test_positives +2427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix–loop interfaces,False,no_term_above_threshold +2428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interface elements,False,no_term_above_threshold +2429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TOPRIM catalytic metal-binding loop,False,no_term_above_threshold +2430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-glucan binding modules,False,no_term_above_threshold +2431,81858,17.597548,0.88964844,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6538086,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,N-terminal signal-anchor helix,True,assigned_too_few_test_positives +2432,15821,15.692175,0.7163086,"transport of virus in host, cell to cell",go_bp,25169,pilus,0.6542969,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,17.0,0.0,1.0,C2/polybasic membrane targeting,True,assigned_too_few_test_positives +2433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal short motif detector,False,no_term_above_threshold +2434,47531,16.602928,0.9355469,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.9355469,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,1.0,18.0,14.035075329566856,0.11260353179459748,Acidic Trp-lined glycan-binding loops,True,assigned_too_few_test_positives +2435,36104,18.15934,0.98535156,Rho GTPase-activating protein domain,interpro,37020,"Glycosyl transferase, family 1",0.93603516,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Nuclear receptor LBD AF-2,True,assigned_too_few_test_positives +2436,49116,16.93027,0.8720703,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8720703,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.905461811722913,0.013423043072907396,0.002215330084182543,,6.059161643110399,1.0,12.0,7.25316301703163,0.20731315521031346,Non-catalytic helical scaffold signature,True,assigned_and_evaluated +2437,82029,17.902449,0.89404297,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.88623047,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,10.0,19.0,98.98887597542752,3.446649782919124e-18,Polybasic helix-edge loops,True,assigned_too_few_test_positives +2438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil oligomerization scaffolds,False,no_term_above_threshold +2439,50806,15.677334,0.99072266,"Homeobox, conserved site",interpro,87384,DNA-binding,0.61816406,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,15.0,15.0,285.26794258373207,5.451728545288471e-37,TF DBD-adjacent disordered tails,True,assigned_too_few_test_positives +2440,87326,23.170761,0.6303711,Coiled coil,keyword,87326,Coiled coil,0.6303711,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6852792404328538,0.3177384083594634,0.03943287549844927,0.3146067415730337,8.057703232216953,15.0,17.0,11.124289428184046,8.236287980885874e-15,Charged coiled-coil scaffold linkers,True,assigned_and_evaluated +2441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helical phosphate-binding motifs,False,no_term_above_threshold +2442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T/P-rich regulatory segments,False,no_term_above_threshold +2443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal subunit docking segment,False,no_term_above_threshold +2444,88178,18.41629,0.67333984,Ubiquinone,keyword,6543,NADH:ubiquinone reductase (H+-translocating),0.6699219,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,0.0,17.0,0.0,1.0,Polar linkers and α/β cores,True,assigned_too_few_test_positives +2445,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic transmembrane helix kinks,False,no_term_above_threshold +2446,63892,19.427887,0.9760742,Fibronectin type III superfamily,interpro,47529,Immunoglobulin-like fold,0.7626953,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,14.0,17.0,238.34780125642487,6.326217497723888e-32,Ectodomain Ig/Fn3 repeats,True,assigned_too_few_test_positives +2447,87409,17.2475,0.75927734,Dioxygenase,keyword,87409,Dioxygenase,0.75927734,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,12.0,15.0,223.92863849765257,4.6561387159919154e-27,DSBH Fe(II)/2OG oxygenase core,True,assigned_too_few_test_positives +2448,50338,17.213293,0.7680664,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.7680664,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,N-terminal acidic specificity motif,True,assigned_too_few_test_positives +2449,58239,19.993774,0.6074219,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6074219,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6969102390617952,0.3115675960497618,0.017722640673460344,0.4,17.58020160710781,20.0,20.0,35.851473241130485,2.9591156525725853e-31,Conserved SMC head motif,True,assigned_and_evaluated +2450,59237,17.303185,0.99072266,Ubiquitin-like domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9892578,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,0.0,20.0,0.0,1.0,Aromatic proline-rich oligomerization motifs,True,assigned_too_few_test_positives +2451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIR N-terminal betaA-alphaA interface,False,no_term_above_threshold +2452,45288,16.770426,0.9980469,CheY-like superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.7573242,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,12.0,12.0,462.17829457364337,2.697122422410576e-32,CheY-like REC switch surface,True,assigned_too_few_test_positives +2453,87326,21.923767,0.6723633,Coiled coil,keyword,87326,Coiled coil,0.6723633,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6431495916082758,0.10525973502905658,0.03943287549844927,0.056179775280898875,2.6693395725907947,4.0,18.0,2.80167289302413,0.08112775501689559,Amphipathic helical interaction motifs,True,assigned_and_evaluated +2454,59224,15.798199,0.8833008,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.8833008,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9471428571428572,0.030358620129598102,0.0031014621178555605,,9.788486518928988,0.0,17.0,0.0,1.0,Aromatic hydrophobic hotspot motifs,True,assigned_and_evaluated +2455,87149,18.525358,0.68896484,Amphibian defense peptide,keyword,88058,Signal,0.68115234,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6804380567839519,0.03468301956751007,0.012405848471422242,,2.795699112995365,0.0,11.0,0.0,1.0,Sec-exported periplasmic domain cores,True,assigned_and_evaluated +2456,37312,15.972049,1.0,"DNA-binding HTH domain, TetR-type",interpro,43624,Homedomain-like superfamily,0.7290039,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,19.0,19.0,864.0724637681159,5.368526660497688e-55,DNA-binding helix N-cap,True,assigned_too_few_test_positives +2457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich phosphate-binding loops,False,no_term_above_threshold +2458,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ciliary/centrosomal coiled-coil scaffolds,False,no_term_above_threshold +2459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM–loop–TM regulatory module,False,no_term_above_threshold +2460,36010,18.735899,0.96533203,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.86621094,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,18.0,0.0,1.0,PHPT active site loop,True,assigned_too_few_test_positives +2461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tetraspan 4-TM membrane proteins,False,no_term_above_threshold +2462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Alpha/beta barrels, cofactor modules",False,no_term_above_threshold +2463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT thumb connection region,False,no_term_above_threshold +2464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular metalloprotease exosite,False,no_term_above_threshold +2465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P/Q/S/T-rich disordered linkers,False,no_term_above_threshold +2466,88058,21.685007,0.6245117,Signal,keyword,88058,Signal,0.6245117,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6229355322764647,0.10737771371064342,0.09127159946832078,,1.1764635914802049,5.0,20.0,1.801238670694864,0.21355299572385222,Membrane-targeting helices and basic LCRs,True,assigned_and_evaluated +2467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ectodomain beta-strand activation,False,no_term_above_threshold +2468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lys/Glu-rich electrostatic scaffolds,False,no_term_above_threshold +2469,36104,22.969072,0.94091797,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.94091797,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Small-xxx-small helices/cores,True,assigned_too_few_test_positives +2470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDH NAD(P)+ cofactor-binding loop,False,no_term_above_threshold +2471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenol-linked glycosyltransferase signal-anchor,False,no_term_above_threshold +2472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ER/Golgi luminal aromatic-acidic motifs,False,no_term_above_threshold +2473,36115,26.126682,0.92871094,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.91748047,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,19.0,0.0,1.0,Domain-boundary hinge caps,True,assigned_too_few_test_positives +2474,38873,18.001774,0.97558594,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95996094,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9923179396092362,0.3084967320261438,0.002215330084182543,0.4,139.25542483660132,11.0,15.0,125.63812260536398,8.352355846328681e-22,Pre-P-loop beta1 flank,True,assigned_and_evaluated +2475,88161,47.97229,0.6489258,Transmembrane helix,keyword,88161,Transmembrane helix,0.6489258,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6308635700135544,0.3828030848328649,0.1847585290208241,0.2949640287769784,2.0719102217452665,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,Polar juxtamembrane loop motif,True,assigned_and_evaluated +2476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tudor-2 proximal activation,False,no_term_above_threshold +2477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional boundary loops; protease C-termini,False,no_term_above_threshold +2478,50338,17.568918,0.73779297,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.73779297,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Amphipathic juxtamembrane segments,True,assigned_too_few_test_positives +2479,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic Pro-Pro loop motif,False,no_term_above_threshold +2480,31094,17.167128,0.99316406,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.7910156,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9965954606141523,0.5683882533677616,0.004430660168365086,0.9,128.28522878510378,0.0,15.0,0.0,1.0,SDR YXXXK active-site loop,True,assigned_and_evaluated +2481,64475,15.967868,0.97753906,ACP-like superfamily,interpro,43624,Homedomain-like superfamily,0.70996094,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9966748937337172,0.46477429777827384,0.0057598582188746125,0.9230769230769231,80.69196846812031,0.0,12.0,0.0,1.0,ABC NBD C-motif helix,True,assigned_and_evaluated +2482,37640,27.408283,0.98828125,EF-hand domain,interpro,46081,EF-hand domain pair,0.9741211,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,16.0,0.0,1.0,Acidic calcium-binding loops,True,assigned_too_few_test_positives +2483,64016,43.777515,0.91308594,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.9116211,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8551746031746031,0.5794575606051017,0.0031014621178555605,0.7142857142857143,186.83367346938778,10.0,10.0,221.63940520446096,8.628605611931638e-24,Thioredoxin C-terminal helix,True,assigned_and_evaluated +2484,36091,17.457476,0.99902344,GNAT domain,interpro,85712,3.40.630.30,0.98535156,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,DHp coiled-coil dimerization helices,True,assigned_too_few_test_positives +2485,87786,17.297071,0.6352539,Mitochondrion inner membrane,keyword,87786,Mitochondrion inner membrane,0.6352539,163,keywords,Mitochondrion inner membrane,keyword:keywords:Mitochondrion inner membrane,15.0,2257.0,0.7186440677966103,0.09955041766999337,0.00664599025254763,,14.979019512078336,3.0,17.0,15.427203726065207,0.0015826592806309416,Disordered TM-adjacent tails,True,assigned_and_evaluated +2486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory disulfide-rich lectin ectodomains,False,no_term_above_threshold +2487,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nop56/58 N-terminal motif,False,no_term_above_threshold +2488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal hairpin and juxtamembrane helices,False,no_term_above_threshold +2489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MAFRHFKxRVR aromatic motif,False,no_term_above_threshold +2490,49061,16.636139,0.6538086,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.6538086,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.5651957956803179,0.04558256399591294,0.012405848471422242,,3.674280247813411,10.0,12.0,82.39496959646213,1.6839739790134307e-18,Beta-propeller fold detector,True,assigned_and_evaluated +2491,45324,23.284508,0.95166016,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.95166016,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9978685612788633,0.3619408369408369,0.002215330084182543,,163.38009379509379,15.0,15.0,546.9816513761467,3.1549135532889026e-41,Short hydrophobic motif near PbH1,True,assigned_and_evaluated +2492,38317,29.054325,0.9995117,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9995117,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9999365079365079,0.982142857142857,0.0031014621178555605,1.0,316.67091836734687,0.0,11.0,0.0,1.0,Alpha-helical interface stripe,True,assigned_and_evaluated +2493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter loop-helix junctions,False,no_term_above_threshold +2494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured-to-disordered boundary segments,False,no_term_above_threshold +2495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase binding groove,False,no_term_above_threshold +2496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HTH regulator C-terminal domains,False,no_term_above_threshold +2497,49116,23.578285,0.91308594,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.91308594,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9964476021314388,0.28929292929292927,0.002215330084182543,,130.5868282828283,16.0,16.0,87.03795620437957,3.1459123761526603e-31,ARM/HEAT solenoid repeats,True,assigned_and_evaluated +2498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ETF-alpha/sheath structured subdomain,False,no_term_above_threshold +2499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rab-GAP post-TBC helical motif,False,no_term_above_threshold +2500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CheW-like coupling domain,False,no_term_above_threshold +2501,87489,16.479008,0.71191406,GPI-anchor,keyword,87489,GPI-anchor,0.71191406,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.6302857142857142,0.16412009198894445,0.0031014621178555605,0.14285714285714285,52.91700680272109,0.0,20.0,0.0,1.0,Mucin-like O-glycosylated stalks,True,assigned_and_evaluated +2502,85656,31.638,0.96484375,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.96484375,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.998984126984127,0.8421768707482993,0.0031014621178555605,0.7142857142857143,271.5418853255588,19.0,19.0,141.281990521327,8.965631807545709e-41,ABH pre-His loop motif,True,assigned_and_evaluated +2503,36115,17.691202,0.9941406,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9941406,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,12.0,0.0,1.0,UBC/E2-like interaction domains,True,assigned_too_few_test_positives +2504,87914,17.691092,0.6738281,Phosphoprotein,keyword,24917,nucleus,0.65625,957,keywords,Phosphoprotein,keyword:keywords:Phosphoprotein,84.0,2257.0,0.7810438717594723,0.15149207591324565,0.03721754541426672,0.05952380952380952,4.070447801621374,13.0,19.0,4.168964311647796,1.2134506531662308e-06,Acidic SLiM-rich disordered regions,True,assigned_and_evaluated +2505,87857,21.499699,0.6196289,Nucleus,keyword,88150,Transcription regulation,0.6147461,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6475502419927871,0.2002884967862918,0.06247230837394772,0.09219858156028368,3.2060364343734795,17.0,19.0,5.42125053487377,1.3036411618123174e-11,PTM-rich disordered regulatory tails,True,assigned_and_evaluated +2506,29104,16.8168,0.7866211,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.6201172,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,16.0,0.0,1.0,Interhelical loops and cap helices,True,assigned_too_few_test_positives +2507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar boxes and catalytic acids,False,no_term_above_threshold +2508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P/G-rich disordered coiled-coil flanks,False,no_term_above_threshold +2509,37446,17.691544,0.9091797,F-box domain,interpro,63831,F-box-like domain superfamily,0.9091797,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9268888888888889,0.022566389734029482,0.0031014621178555605,,7.276048804243506,0.0,18.0,0.0,1.0,Conserved threonine motif signal,True,assigned_and_evaluated +2510,55053,16.77931,0.9111328,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9111328,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,16.0,0.0,1.0,PBP/β-lactamase C-terminal helix/tail,True,assigned_too_few_test_positives +2511,37020,17.430069,0.99853516,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,18.0,771.3523592085236,3.565291332168778e-48,Leloir glycosyltransferase DxD loop,True,assigned_too_few_test_positives +2512,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate pocket caps and interfaces,False,no_term_above_threshold +2513,87925,15.633624,0.68847656,Plant defense,keyword,87925,Plant defense,0.68847656,171,keywords,Plant defense,keyword:keywords:Plant defense,13.0,2257.0,0.7182229535170712,0.14687435589074935,0.0057598582188746125,,25.49964778810933,0.0,18.0,0.0,1.0,Disulfide-stabilized PAN/Apple fold,True,assigned_and_evaluated +2514,81685,24.687939,0.96972656,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9638672,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9576837416481069,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,17.0,17.0,85.66235632183908,5.1673760881485446e-33,Kinase DFG hydrophobe detector,True,assigned_and_evaluated +2515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal functional module detector,False,no_term_above_threshold +2516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GST-like helical H-site,False,no_term_above_threshold +2517,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interaction scaffolds,False,no_term_above_threshold +2518,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PNPLA serine hydrolase core,False,no_term_above_threshold +2519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse low-amplitude sequence-wide activation,False,no_term_above_threshold +2520,36091,20.605019,0.9145508,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.83935547,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase ATP-binding core,True,assigned_too_few_test_positives +2521,37690,17.312426,0.9291992,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9189453,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9360952380952381,0.028286069571577515,0.0031014621178555605,,9.120237003292921,0.0,17.0,0.0,1.0,Alpha-helical active-site scaffolds,True,assigned_and_evaluated +2522,36104,22.726923,0.92626953,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.92626953,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,RelE toxins and TrmO/TsaA methyltransferases,True,assigned_too_few_test_positives +2523,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta catalytic core helix,False,no_term_above_threshold +2524,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC ATPase H-loop glycine,False,no_term_above_threshold +2525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short basic-hydrophobic micro-motif,False,no_term_above_threshold +2526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal charged coiled-coil scaffolds,False,no_term_above_threshold +2527,87326,26.944904,0.63623047,Coiled coil,keyword,87326,Coiled coil,0.63623047,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6479720344956258,0.2575900346114217,0.03943287549844927,0.24719101123595505,6.532367506943582,15.0,19.0,9.953311593638357,1.9419723269777084e-13,Long coiled-coil scaffolds,True,assigned_and_evaluated +2528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated helical assembly tethers,False,no_term_above_threshold +2529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic interaction helices,False,no_term_above_threshold +2530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"LTV1/MPP10 motifs, TruD helix",False,no_term_above_threshold +2531,69819,21.430546,0.94091797,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.88623047,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,N-terminal β–loop–α motif,True,assigned_too_few_test_positives +2532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix capping,False,no_term_above_threshold +2533,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic terminal lipid-binding segment,False,no_term_above_threshold +2534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction modules,False,no_term_above_threshold +2535,85664,21.471855,0.98046875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98046875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase donor binding site,True,assigned_too_few_test_positives +2536,85672,21.570538,0.80126953,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7885742,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8536257441592876,0.14100488049631849,0.01595037660611431,,8.840222646671968,3.0,13.0,9.234021683014973,0.006370515796108616,Helix–β junction hinge loops,True,assigned_and_evaluated +2537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,A1 aspartic protease propeptide,False,no_term_above_threshold +2538,38317,26.367397,0.97509766,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.97509766,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8523809523809525,0.33371821223417425,0.0031014621178555605,0.14285714285714285,107.6002864303616,0.0,10.0,0.0,1.0,Plant extracellular LRR ectodomain,True,assigned_and_evaluated +2539,59229,22.723047,0.95654297,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.95654297,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9617764976061656,0.5190124875697574,0.0101905183872397,0.6956521739130435,50.93092106282358,1.0,17.0,6.251546607947992,0.2361534288859562,Helix-to-strand capping loop,True,assigned_and_evaluated +2540,80926,20.446796,0.7363281,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.7114258,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.6772932949403537,0.061316635906799845,0.0057598582188746125,,10.645511326280557,14.0,16.0,83.4694,6.179906846437864e-26,Acidic N-termini and Myb/HTH,True,assigned_and_evaluated +2541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type IV pilin head domain,False,no_term_above_threshold +2542,87852,15.627672,0.9140625,Nucleosome core,keyword,87852,Nucleosome core,0.9140625,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,3.0,19.0,99.09307479224377,7.044229033603779e-06,K/R-rich disordered polyanion-binding tracts,True,assigned_too_few_test_positives +2543,59229,34.678684,0.9790039,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9790039,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8646023899420031,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM Motif I loop glycine,True,assigned_and_evaluated +2544,37690,28.814707,0.9785156,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9658203,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9827936507936508,0.36860544217687075,0.0031014621178555605,0.5714285714285714,118.84892614188533,0.0,14.0,0.0,1.0,Histidine kinase G1 glycine loop,True,assigned_and_evaluated +2545,87970,15.690146,0.7011719,Protein phosphatase,keyword,87970,Protein phosphatase,0.7011719,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,17.0,0.0,1.0,GATase/ATP-PPase boundary,True,assigned_too_few_test_positives +2546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Icosahedral capsid β-strand signature,False,no_term_above_threshold +2547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavoprotein oxidoreductase active sites,False,no_term_above_threshold +2548,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sticker-spacer tandem-repeat IDRs,False,no_term_above_threshold +2549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PPK1 conserved motif peaks,False,no_term_above_threshold +2550,87409,19.813473,0.8022461,Dioxygenase,keyword,87409,Dioxygenase,0.8022461,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,14.0,15.0,261.25007824726134,2.4699176185000654e-33,Fe(II)/2OG oxygenase catalytic core,True,assigned_too_few_test_positives +2551,38873,19.639114,0.98876953,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.94970703,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9988454706927177,0.75,0.002215330084182543,0.8,338.55,16.0,17.0,161.24678837052062,1.0847628323589438e-34,Walker A P-loop motif,True,assigned_and_evaluated +2552,59229,17.144075,0.6303711,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6303711,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.5589700673387566,0.04944103048165771,0.0101905183872397,0.08695652173913043,4.851669817265281,15.0,18.0,88.56357694592988,8.927444796513371e-28,Methyltransferase accessory recognition regions,True,assigned_and_evaluated +2553,36409,18.22035,0.99560547,"Zinc finger, CCCH-type",interpro,87697,Knottin,0.8442383,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,13.0,0.0,1.0,Beta-strand linking turns,True,assigned_too_few_test_positives +2554,49116,22.604685,0.9345703,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9345703,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9952042628774422,0.48376068376068376,0.002215330084182543,0.6,218.36957264957266,2.0,20.0,8.703795620437957,0.03670159417435684,Coiled-coil and alpha-solenoid scaffolds,True,assigned_and_evaluated +2555,48767,15.816493,0.9951172,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.89501953,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,17.0,0.0,1.0,Short hydrophobic capping loops,True,assigned_too_few_test_positives +2556,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich mucin-like disordered regions,False,no_term_above_threshold +2557,36091,16.741814,0.78222656,GNAT domain,interpro,36091,GNAT domain,0.78222656,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,Glyoxalase/VOC metal-binding core,True,assigned_too_few_test_positives +2558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal/periplasmic membrane biogenesis signal,False,no_term_above_threshold +2559,58239,17.655933,0.7314453,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7742275597654489,0.16961384400779625,0.017722640673460344,0.1,9.570461148139904,2.0,13.0,5.515611267866229,0.08148153629691804,GH27 N-glycosylated helix motif,True,assigned_and_evaluated +2560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular soluble domain motifs,False,no_term_above_threshold +2561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix caps and beta-strand loops,False,no_term_above_threshold +2562,63892,17.437962,0.76416016,Fibronectin type III superfamily,interpro,63892,Fibronectin type III superfamily,0.76416016,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,14.0,17.0,238.34780125642487,6.326217497723888e-32,Membrane-proximal proline-rich IDRs,True,assigned_too_few_test_positives +2563,37894,18.523386,1.0,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.97558594,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,17.0,17.0,709.7738095238095,2.951243259467613e-48,N-terminal Rossmann NAD(P)-binding motif,True,assigned_too_few_test_positives +2564,45714,17.95212,0.8647461,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.8647461,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,16.0,0.0,1.0,YdiU/SelO C-terminal FRxLA motif,True,assigned_too_few_test_positives +2565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDR interaction motifs,False,no_term_above_threshold +2566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IQ-adjacent regulatory low-complexity IDRs,False,no_term_above_threshold +2567,85656,16.04013,0.64208984,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.64208984,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.7795555555555556,0.09071600172302748,0.0031014621178555605,,29.24943084126757,17.0,18.0,133.43299104791996,1.9384258312242024e-35,AB hydrolase lid activation,True,assigned_and_evaluated +2568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alpha-helix detector,False,no_term_above_threshold +2569,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAL c-di-GMP phosphodiesterase,False,no_term_above_threshold +2570,85649,26.585375,0.73339844,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7285156,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7778794130240161,0.3957873339819959,0.0101905183872397,0.4782608695652174,38.83878316510281,11.0,12.0,101.39625850340136,9.654716207441392e-22,Rossmann-like SAM MTase domain,True,assigned_and_evaluated +2571,36449,17.614922,0.8378906,EamA domain,interpro,36449,EamA domain,0.8378906,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,14.0,0.0,1.0,Basic disordered cytosolic tails,True,assigned_too_few_test_positives +2572,59229,17.260498,0.88427734,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7836914,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9177532988205988,0.0791871423514783,0.0101905183872397,,7.7706687081428925,4.0,15.0,28.34034462269756,1.820644829608249e-05,Short conserved sequence patches,True,assigned_and_evaluated +2573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic lipid-pocket beta-strands,False,no_term_above_threshold +2574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic-tract DE motif,False,no_term_above_threshold +2575,85656,32.83958,0.75341797,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.75341797,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.7121269841269842,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,15.0,15.0,141.281990521327,1.9050930748244927e-32,Alpha/beta-hydrolase serine hydrolases,True,assigned_and_evaluated +2576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD superfamily central beta strand,False,no_term_above_threshold +2577,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Sec export marker,False,no_term_above_threshold +2578,45290,21.65887,0.9628906,Protein kinase-like domain superfamily,interpro,87855,Nucleotide-binding,0.70996094,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9840257781434253,0.8690314321344307,0.0057598582188746125,0.9230769230769231,150.87722633287768,16.0,16.0,73.42487684729065,4.583656533651311e-30,Protein kinase-like catalytic core scaffold,True,assigned_and_evaluated +2579,46929,25.607006,0.91845703,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.73535156,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.6878330373001776,0.05466253138384286,0.002215330084182543,,24.67466666666667,16.0,20.0,68.72737752161383,1.4842223150409215e-27,Charged flanking/linker IDRs,True,assigned_and_evaluated +2580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface polar beta-strand residues,False,no_term_above_threshold +2581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended ectodomains and surface loops,False,no_term_above_threshold +2582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded surface and ECF-sigma domains,False,no_term_above_threshold +2583,81685,21.598797,0.95654297,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.8857422,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9570155902004454,0.9171097326835032,0.005316792202038104,0.9166666666666666,172.49305555555554,16.0,16.0,85.66235632183908,4.040725274098586e-31,Kinase C-lobe Dx4-hydrophobic-G helix,True,assigned_and_evaluated +2584,49236,16.875109,0.765625,C-type lectin fold,interpro,49236,C-type lectin fold,0.765625,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.8957815275310834,0.2058816625080646,0.002215330084182543,,92.93498245614038,0.0,14.0,0.0,1.0,Protease catalytic core motifs,True,assigned_and_evaluated +2585,59218,15.966849,0.6894531,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.6894531,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,11.0,11.0,557.2056074766355,1.4239557776488535e-30,PPP-centric phosphohydrolase scaffold detector,True,assigned_too_few_test_positives +2586,87697,17.14849,0.8027344,Knottin,keyword,87413,Disulfide bond,0.61865234,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8159175510392824,0.04642500398931685,0.017279574656623838,,2.6866983077920032,0.0,15.0,0.0,1.0,General beta-strand residue detector,True,assigned_and_evaluated +2587,64003,24.598104,0.87402344,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.8676758,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9387603795966785,0.5248146586255111,0.003987594151528578,0.6666666666666666,131.61185383530875,10.0,18.0,72.478725990761,6.390136607990502e-17,C2H2-flanking low-complexity transactivation IDRs,True,assigned_and_evaluated +2588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed beta-loop interfaces,False,no_term_above_threshold +2589,48767,15.879388,0.98779297,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.98779297,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,13.0,0.0,1.0,Eukaryotic TF DNA-binding domains,True,assigned_too_few_test_positives +2590,37341,22.638086,0.9980469,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9980469,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.999817306095333,0.9821107165632121,0.011962782454585734,1.0,82.09718101048777,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 blade B-strand motif,True,assigned_and_evaluated +2591,82029,17.189758,0.8457031,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69189453,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,18.0,10.448825797406238,0.1483822125694642,Transmembrane aromatic belt,True,assigned_too_few_test_positives +2592,88263,34.604805,0.8515625,Zinc-finger,keyword,88261,Zinc,0.79296875,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8946138543710487,0.1482112818183098,0.014621178555604785,,10.136753426179553,0.0,16.0,0.0,1.0,Conserved short activation segments,True,assigned_and_evaluated +2593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered helix-loop hinges,False,no_term_above_threshold +2594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cationic amphipathic motifs,False,no_term_above_threshold +2595,61392,22.192719,0.98535156,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.98535156,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9918730158730159,0.2523679336802187,0.0031014621178555605,0.2857142857142857,81.37063233089337,0.0,18.0,0.0,1.0,Solvent exposed solenoid loop tips,True,assigned_and_evaluated +2596,29104,15.919695,0.6435547,NADH dehydrogenase (ubiquinone) activity,go_mf,88178,Ubiquinone,0.63916016,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,2.0,17.0,50.462124418112566,0.0012663400161836728,Alpha-helical transmembrane segments,True,assigned_too_few_test_positives +2597,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KS/thiolase active-site β-strand,False,no_term_above_threshold +2598,38878,16.699596,0.99072266,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.9003906,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,14.0,19.0,164.5365661344372,3.7958279824341706e-29,Conserved Ig/PKD surface motifs,True,assigned_too_few_test_positives +2599,63831,17.921062,0.89160156,F-box-like domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8305664,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8613949355841848,0.010527703950825045,0.002658396101019052,,3.960171302835354,0.0,20.0,0.0,1.0,Structural transition anchor residues,True,assigned_and_evaluated +2600,80926,15.943534,0.8046875,Homeodomain-like,gene3d,80926,Homeodomain-like,0.8046875,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.7124468668586317,0.09371564752624242,0.0057598582188746125,0.15384615384615385,16.270478189748395,3.0,15.0,19.07872,0.0008445595340070033,Eukaryotic regulatory helical modules,True,assigned_and_evaluated +2601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NPR longin-fold central hotspot,False,no_term_above_threshold +2602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxidoreductase N-terminal accessory cap,False,no_term_above_threshold +2603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved extramembrane functional hotspots,False,no_term_above_threshold +2604,45553,17.898119,0.9609375,Restriction endonuclease type II-like,interpro,45290,Protein kinase-like domain superfamily,0.80078125,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,6.0,16.0,256.98706896551727,1.4468016527079799e-13,Nuclease active-site ββ-loop hairpin,True,assigned_too_few_test_positives +2605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alpha-helical interface motifs,False,no_term_above_threshold +2606,64085,17.67193,0.6855469,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.66503906,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.8716192398897648,0.4902065119541673,0.012405848471422242,0.75,39.514146338591274,0.0,15.0,0.0,1.0,Beta-propeller surface loop signature,True,assigned_and_evaluated +2607,64596,33.680737,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,19.0,19.0,614.6494845360825,4.63144682888448e-52,N-terminal MBL-fold scaffold,True,assigned_too_few_test_positives +2608,87852,15.943565,0.7963867,Nucleosome core,keyword,87852,Nucleosome core,0.7963867,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,10.0,0.0,1.0,Low-complexity tandem repeats,True,assigned_too_few_test_positives +2609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory and anchoring regions,False,no_term_above_threshold +2610,37468,28.07302,0.9189453,"Zinc finger, RING-type",interpro,37468,"Zinc finger, RING-type",0.9189453,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,13.0,14.0,127.5630348913759,6.078843089540087e-27,RING/DHHC-adjacent cytosolic linkers,True,assigned_too_few_test_positives +2611,48880,19.697752,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",1.0,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,PLP N-terminal active-site gate,True,assigned_too_few_test_positives +2612,82029,24.942444,0.99902344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.60595703,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,MFS membrane-interface helix caps,True,assigned_too_few_test_positives +2613,64058,21.90936,0.9458008,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9316406,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9917521176995095,0.29665110261672,0.006202924235711121,,47.824395614709786,0.0,19.0,0.0,1.0,Beta strand initiation residues,True,assigned_and_evaluated +2614,82608,15.910889,0.75927734,Ankyrin repeat-containing domain,gene3d,88240,Virulence,0.62597656,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.7787905735882615,0.021107530739471626,0.003544528134692069,,5.954962109873432,0.0,17.0,0.0,1.0,Broad whole-chain effector activation,True,assigned_and_evaluated +2615,8138,38.885475,0.88720703,translation,go_bp,88022,Ribosomal protein,0.8330078,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.985647618209034,0.8485725582668932,0.018165706690296855,0.926829268292683,46.712884488009216,8.0,8.0,103.15051903114187,1.7865204112757912e-16,Bacterial ribosomal RNA-binding cores,True,assigned_and_evaluated +2616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RCK gating-ring CTDs,False,no_term_above_threshold +2617,88161,40.18272,0.68847656,Transmembrane helix,keyword,88161,Transmembrane helix,0.68847656,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7482737722865187,0.5342199648021242,0.1847585290208241,0.4748201438848921,2.8914495457035834,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Juxtamembrane interfacial helices,True,assigned_and_evaluated +2618,43643,17.368193,0.94091797,Phosphopantetheine binding ACP domain,interpro,43643,Phosphopantetheine binding ACP domain,0.94091797,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,0.9095022624434389,0.044348752872932745,0.0057598582188746125,,7.699625787246862,0.0,18.0,0.0,1.0,Aromatic amphipathic interaction helix,True,assigned_and_evaluated +2619,63960,23.449423,0.78466797,FAD/NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.70410156,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,17.0,17.0,193.57467532467533,6.347107800690125e-39,Dinucleotide-binding catalytic cap,True,assigned_too_few_test_positives +2620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic β-strand glycan-binding patches,False,no_term_above_threshold +2621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical assembly and substrate interfaces,False,no_term_above_threshold +2622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor hinge,False,no_term_above_threshold +2623,36535,17.86318,0.90771484,Protein kinase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6748047,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9741433021806853,0.13509443947693167,0.004430660168365086,,30.49081498994348,0.0,7.0,0.0,1.0,ABC NBD coupling/switch loop,True,assigned_and_evaluated +2624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged surface binding motifs,False,no_term_above_threshold +2625,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular polysaccharide-binding catalytic grooves,False,no_term_above_threshold +2626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature C-terminal interaction domains,False,no_term_above_threshold +2627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical scaffold domains,False,no_term_above_threshold +2628,87276,35.10337,0.6503906,Cell membrane,keyword,88161,Transmembrane helix,0.61816406,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7534339213435391,0.43639804820444056,0.11120957022596367,0.549800796812749,3.9241051585554674,10.0,19.0,4.318672403552233,4.3047937797857006e-05,Final TM and C-terminal tail,True,assigned_and_evaluated +2629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured core packing residues,False,no_term_above_threshold +2630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader/targeting segments,False,no_term_above_threshold +2631,52941,16.509077,0.93847656,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.70410156,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane kink/loop junction motifs,True,assigned_too_few_test_positives +2632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic pepsin-like A1 scaffold,False,no_term_above_threshold +2633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic/basic pocket-edge patch,False,no_term_above_threshold +2634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Disordered regions, avoids catalytic cores",False,no_term_above_threshold +2635,82029,28.791508,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Transporter cytosolic helix-loop hinges,True,assigned_too_few_test_positives +2636,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase NTP/Mg2+ binding pocket,False,no_term_above_threshold +2637,64016,41.57074,0.9633789,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.9633789,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9257460317460317,0.48634050191427236,0.0031014621178555605,0.5714285714285714,156.81007326007324,12.0,15.0,177.31152416356878,7.796381668785699e-26,ER glycoprotein quality-control signature,True,assigned_and_evaluated +2638,38873,15.828614,0.78222656,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.67041016,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.794138543516874,0.17302898917653015,0.002215330084182543,,78.10528571428571,1.0,20.0,8.56623563218391,0.1783649129114171,ABC ATPase C-loop signature motif,True,assigned_and_evaluated +2639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mammalian PTM-dense regulatory IDRs,False,no_term_above_threshold +2640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal regulatory modules,False,no_term_above_threshold +2641,37291,15.720296,0.8588867,DnaJ domain,interpro,37291,DnaJ domain,0.8588867,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,0.0,16.0,0.0,1.0,HECT ligase acidic IDRs,True,assigned_too_few_test_positives +2642,29034,16.548777,0.6381836,GTP binding,go_mf,29034,GTP binding,0.6381836,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.6709991059454626,0.2390691415281579,0.008861320336730172,0.2,26.97895262145262,11.0,13.0,109.67073578595317,1.0694639343362066e-21,P-loop GTPase coupling elements,True,assigned_and_evaluated +2643,58239,17.105337,0.6303711,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6303711,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6153247631935047,0.16587592433903908,0.017722640673460344,0.15,9.35954903083028,12.0,19.0,22.643035731240307,2.0719536953296207e-14,Alpha-helical coiled-coil stalks,True,assigned_and_evaluated +2644,82029,21.808475,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9941406,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,MFS transmembrane cavity gating residues,True,assigned_too_few_test_positives +2645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extension marker,False,no_term_above_threshold +2646,85762,24.865944,0.8129883,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.79589844,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,18.0,205.58965517241379,1.4365296813653038e-41,Flavin and iron oxidoreductase scaffold,True,assigned_too_few_test_positives +2647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil heptad face register,False,no_term_above_threshold +2648,43643,17.514458,0.8964844,Phosphopantetheine binding ACP domain,interpro,87913,Phosphopantetheine,0.8876953,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,0.9206088029617443,0.4362400566409913,0.0057598582188746125,0.8461538461538461,75.73798521836287,0.0,16.0,0.0,1.0,PAS/HAMP-adjacent regulatory helices,True,assigned_and_evaluated +2649,64058,26.38605,0.74121094,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7324219,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8509012164830266,0.36187845770759286,0.006202924235711121,0.6428571428571429,58.339977074716934,10.0,17.0,67.05769879653582,1.1001919723259444e-16,E1 pre-adenylation linker motif,True,assigned_and_evaluated +2650,43538,15.897189,0.9741211,Rho GTPase activation protein,interpro,43538,Rho GTPase activation protein,0.9741211,34,ip,IPR008936,interpro:ip:IPR008936,,,,,,,,0.0,17.0,0.0,1.0,Cyclin-like helical PPI core,True,assigned_too_few_test_positives +2651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding cap region,False,no_term_above_threshold +2652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Group II chaperonin equatorial helices,False,no_term_above_threshold +2653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Globular domain cores with hotspots,False,no_term_above_threshold +2654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Activated C-terminal disordered tails,False,no_term_above_threshold +2655,88001,16.569164,0.6464844,RNA-binding,keyword,88001,RNA-binding,0.6464844,361,keywords,RNA-binding,keyword:keywords:RNA-binding,80.0,2257.0,0.5742363344051447,0.10850115654410658,0.03544528134692069,0.1375,3.061088879000607,8.0,19.0,13.275292938851623,1.1035866036469447e-07,Prion-like RNA granule IDRs,True,assigned_and_evaluated +2656,82029,16.265972,0.66503906,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.6616211,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,15.0,0.0,1.0,Multi-pass transporter helix bundles,True,assigned_too_few_test_positives +2657,45290,29.331326,0.97558594,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97558594,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9993829699712052,0.9504930966469428,0.0057598582188746125,0.9230769230769231,165.0202245486269,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Kinase P-loop ATP-binding,True,assigned_and_evaluated +2658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serpin-enriched noncatalytic surface regions,False,no_term_above_threshold +2659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal tails/helices,False,no_term_above_threshold +2660,85672,38.69696,0.97265625,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9682617,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9444506978838361,0.6629548358607223,0.01595037660611431,0.7222222222222222,41.563585126045844,7.0,7.0,40.01409395973155,1.2993239531220957e-11,AAA+ ATPase core motifs,True,assigned_and_evaluated +2661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P450 catalytic core helix,False,no_term_above_threshold +2662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical rods,False,no_term_above_threshold +2663,64003,21.88567,0.9975586,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.8935547,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,17.0,130.4617067833698,4.534127311811392e-36,C2H2 zinc finger loop residue,True,assigned_and_evaluated +2664,87522,23.537882,0.60791016,Glycoprotein,keyword,87522,Glycoprotein,0.60791016,1135,keywords,Glycoprotein,keyword:keywords:Glycoprotein,89.0,2257.0,0.7249782329283967,0.18680339538959936,0.03943287549844927,0.02247191011235955,4.737250150498043,12.0,18.0,6.97199321756417,1.2481895523108282e-08,Extracellular loop–helix boundary motif,True,assigned_and_evaluated +2665,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chlorophyll cyclase N-terminal peak,False,no_term_above_threshold +2666,85672,17.049316,0.73583984,P-loop containing nucleotide triphosphate hydrolases,gene3d,88153,Transferase,0.66748047,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8312509380159088,0.0780628379021841,0.01595037660611431,,4.894106254034154,1.0,17.0,2.353770232925385,0.5462220288242882,Proline-centered helix-strand turn,True,assigned_and_evaluated +2667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory insertions and inteins,False,no_term_above_threshold +2668,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor binding catalytic core loops,False,no_term_above_threshold +2669,52941,22.929134,0.89746094,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.86865234,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,3.0,16.0,48.81632096069869,5.574183918675319e-05,Histidine-rich disordered transporter loops,True,assigned_too_few_test_positives +2670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid processing cores,False,no_term_above_threshold +2671,46078,19.728634,0.9794922,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9790039,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,18.0,18.0,130.74780701754386,3.9193799829466193e-38,Alpha-solenoid hydrophobic ladder,True,assigned_too_few_test_positives +2672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-anchored glycine-rich redox loop,False,no_term_above_threshold +2673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cortical polarity S/T/P-rich IDRs,False,no_term_above_threshold +2674,45272,27.405159,0.9995117,"Lambda repressor-like, DNA-binding domain superfamily",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9995117,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,16.0,17.0,418.7603160667252,2.902560589967525e-41,N-terminal basic helix-loop element,True,assigned_too_few_test_positives +2675,38654,25.833857,0.9399414,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9316406,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,20.0,0.0,1.0,Core DNA-binding domain activation,True,assigned_too_few_test_positives +2676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended terminal binding segment,False,no_term_above_threshold +2677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter extracellular loop interfaces,False,no_term_above_threshold +2678,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site β-strand-loop modules,False,no_term_above_threshold +2679,20285,15.630698,0.7167969,viral tail assembly,go_bp,20285,viral tail assembly,0.7167969,25,go,GO:0098003,go_bp:go:GO:0098003,,,,,,,,0.0,18.0,0.0,1.0,Extracytoplasmic transporter loops,True,assigned_too_few_test_positives +2680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1-adjacent luminal loop-helix,False,no_term_above_threshold +2681,59237,16.995157,0.9941406,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.9941406,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,4.0,20.0,62.75894736842106,9.009590536591661e-07,Short beta strand-coil segment,True,assigned_too_few_test_positives +2682,4066,20.17773,0.8120117,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.8120117,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7955595026642984,0.21755279870033967,0.002215330084182543,0.2,98.20333333333333,0.0,18.0,0.0,1.0,RdRp/L polymerase and Cap4,True,assigned_and_evaluated +2683,37894,16.666656,0.9921875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.92578125,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,CA-domain alpha-helix peak,True,assigned_too_few_test_positives +2684,47717,16.667875,0.82128906,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.60058594,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,20.0,0.0,1.0,Interdomain coupling hinges,True,assigned_too_few_test_positives +2685,47529,20.26387,0.95410156,Immunoglobulin-like fold,interpro,88058,Signal,0.65527344,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.970855644801428,0.2121742256954157,0.007089056269384138,,29.929826712159578,3.0,18.0,12.88824038045828,0.0026528961134651414,Conserved beta-sandwich strand hotspot,True,assigned_and_evaluated +2686,82029,29.192595,0.99365234,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9848633,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS cytosolic N-cap helices,True,assigned_too_few_test_positives +2687,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact glycine-rich single-domain proteins,False,no_term_above_threshold +2688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CorA-like pre-TM regulatory domain,False,no_term_above_threshold +2689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed helical binding surfaces,False,no_term_above_threshold +2690,85364,24.040438,0.97216797,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.97216797,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,20.0,271.00454545454545,2.4396380434571384e-42,Venus flytrap ligand-binding domain,True,assigned_too_few_test_positives +2691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-proximal helix-strand segments,False,no_term_above_threshold +2692,88058,20.418587,0.6269531,Signal,keyword,88058,Signal,0.6269531,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6314857067118573,0.11229371271153386,0.09127159946832078,,1.230324803834621,2.0,19.0,0.7584162823978374,1.0,Compositionally biased disordered LCRs,True,assigned_and_evaluated +2693,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bromodomain acetyl-lysine reader,False,no_term_above_threshold +2694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T-rich lumenal domains,False,no_term_above_threshold +2695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader/domain-start detector,False,no_term_above_threshold +2696,42054,15.762765,0.9980469,Radical SAM,interpro,87681,Iron-sulfur,0.70996094,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,11.0,12.0,621.0520833333334,1.7554986321521317e-30,Acidic flexible domain linkers,True,assigned_too_few_test_positives +2697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-facing transmembrane helical bundles,False,no_term_above_threshold +2698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-to-C-terminal functional tails,False,no_term_above_threshold +2699,66234,16.909603,0.8208008,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.8208008,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,6.0,17.0,83.50280112044818,1.3502727990724917e-10,Papain-like cysteine protease core,True,assigned_too_few_test_positives +2700,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal chain-start signal,False,no_term_above_threshold +2701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/His-rich glycosidase active sites,False,no_term_above_threshold +2702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-binding propeller loop signatures,False,no_term_above_threshold +2703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad SAM MTase fold activation,False,no_term_above_threshold +2704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic soluble beta-edge hotspots,False,no_term_above_threshold +2705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA origin-binding nickase module,False,no_term_above_threshold +2706,85364,19.148115,0.9736328,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9736328,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,20.0,255.94873737373737,3.1365718675403606e-39,PBP/VFT β-strand-flanking loops,True,assigned_too_few_test_positives +2707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short ordered beta-strand patches,False,no_term_above_threshold +2708,85656,17.15083,0.93603516,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8457031,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9615555555555556,0.041702823556300825,0.0031014621178555605,,13.446181823795852,0.0,20.0,0.0,1.0,GH5 mannanase GxDFxxN motif,True,assigned_and_evaluated +2709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphorylated transcriptional IDRs,False,no_term_above_threshold +2710,64016,44.324966,0.9926758,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.9921875,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9984126984126984,0.6411364545818328,0.0031014621178555605,0.7142857142857143,206.7207111415995,16.0,16.0,221.63940520446096,1.219801719998429e-37,Thioredoxin-like redox surface,True,assigned_and_evaluated +2711,87489,29.720114,0.9272461,GPI-anchor,keyword,87489,GPI-anchor,0.9272461,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9254285714285715,0.4196349852087557,0.0031014621178555605,0.8571428571428571,135.3023088023088,17.0,17.0,147.21234567901234,6.096588734175852e-37,Extracellular glycoprotein ectodomains,True,assigned_and_evaluated +2712,30856,16.254051,0.7763672,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.6870117,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7370337477797514,0.03859083867454987,0.002215330084182543,,17.419904577691813,1.0,17.0,7.881163251817581,0.19225620345400493,Transmembrane helix capping motifs,True,assigned_and_evaluated +2713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered regions,False,no_term_above_threshold +2714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha junction motifs,False,no_term_above_threshold +2715,82029,27.06531,0.99853516,MFS general substrate transporter like domains,gene3d,88162,Transport,0.6142578,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Alternating-access gating helices,True,assigned_too_few_test_positives +2716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix interaction surface,False,no_term_above_threshold +2717,85672,23.399548,0.6567383,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.65185547,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6173582970633849,0.14463136500121707,0.01595037660611431,0.16666666666666666,9.067583077992971,17.0,17.0,40.01409395973155,1.7557395315514075e-27,Pre-motif N-terminal capping segment,True,assigned_and_evaluated +2718,36886,27.279026,0.9614258,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9614258,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9362772343263671,0.7213575681813387,0.003544528134692069,0.875,203.51300392316017,18.0,18.0,233.80784313725488,1.5159322438572416e-42,Fungal Zn2C6 hydrophobic activation patches,True,assigned_and_evaluated +2719,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-edge to alpha-helix cap,False,no_term_above_threshold +2720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global activation with binding-site peaks,False,no_term_above_threshold +2721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity IDRs with glycine motifs,False,no_term_above_threshold +2722,38317,16.018206,0.72216797,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.72216797,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7282857142857142,0.011638370833029855,0.0031014621178555605,,3.752543281449769,0.0,20.0,0.0,1.0,Cationic amphipathic N-terminal leaders,True,assigned_and_evaluated +2723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular fibers and coiled-coils,False,no_term_above_threshold +2724,63960,31.536728,0.80908203,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.80908203,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,FAD-proximal beta/loop scaffold,True,assigned_too_few_test_positives +2725,88164,18.283953,0.8642578,Transposition,keyword,88163,Transposable element,0.7036133,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.6821936056838365,0.07371015043146191,0.002215330084182543,,33.27276190476191,1.0,13.0,55.929643527204504,0.02994848636161417,RNase H-like active-site helix,True,assigned_and_evaluated +2726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity coactivator IDRs,False,no_term_above_threshold +2727,38873,17.21739,0.7084961,AAA+ ATPase domain,interpro,30398,ATP hydrolysis activity,0.63671875,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7985790408525755,0.6008861320336729,0.002215330084182543,0.6,271.23999999999995,9.0,9.0,171.32471264367817,1.8650004750458193e-20,ABC ATPase C-terminal tail,True,assigned_and_evaluated +2728,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved core beta-strands,False,no_term_above_threshold +2729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP sulfur-amino lyase core,False,no_term_above_threshold +2730,38317,15.876906,0.9873047,Pentatricopeptide repeat,interpro,88009,Repeat,0.67333984,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9175238095238095,0.0934535042587753,0.0031014621178555605,,30.132079873150836,0.0,20.0,0.0,1.0,Helix N-cap and beta-alpha junctions,True,assigned_and_evaluated +2731,72011,16.637833,0.94677734,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.89746094,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,PAS/PAC sensory relay modules,True,assigned_too_few_test_positives +2732,88161,68.547,0.77490234,Transmembrane helix,keyword,88161,Transmembrane helix,0.77490234,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7864104368678969,0.5975057297780212,0.1847585290208241,0.6738609112709832,3.233981851580321,15.0,16.0,5.088273782430587,2.6333800559346605e-10,Transmembrane helices and junctions,True,assigned_and_evaluated +2733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Allosteric coiled-coil linkers,False,no_term_above_threshold +2734,87149,20.626818,0.72216797,Amphibian defense peptide,keyword,88058,Signal,0.6904297,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8014083830032686,0.05399905975333459,0.012405848471422242,,4.352709923688435,0.0,15.0,0.0,1.0,Extracytoplasmic enzymes and SBPs,True,assigned_and_evaluated +2735,38317,17.809875,0.8354492,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.80029297,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.5607619047619047,0.009151902594525545,0.0031014621178555605,,2.9508348794063077,0.0,20.0,0.0,1.0,TPR regulator N-terminal helices,True,assigned_and_evaluated +2736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,XPC/RAD4 DNA damage sensor,False,no_term_above_threshold +2737,37097,19.247477,0.9267578,Cro/C1-type helix-turn-helix domain,interpro,87384,DNA-binding,0.6279297,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,16.0,0.0,1.0,Bacterial HTH DNA-binding motifs,True,assigned_too_few_test_positives +2738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CheB methylesterase domain marker,False,no_term_above_threshold +2739,36354,16.85774,0.9355469,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.92041016,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,17.0,0.0,1.0,Gly-aromatic beta-strand interface motif,True,assigned_too_few_test_positives +2740,88161,42.801247,0.61083984,Transmembrane helix,keyword,88159,Transmembrane,0.6098633,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6321773016369514,0.3945783830112855,0.1847585290208241,0.3117505995203837,2.135643670159404,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Alpha-helical transmembrane segments,True,assigned_and_evaluated +2741,88263,34.25356,0.8652344,Zinc-finger,keyword,29166,zinc ion binding,0.8232422,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8732763788968826,0.21333257528896568,0.014621178555604785,0.09090909090909091,14.590655225066532,14.0,16.0,22.800863199300696,4.0083581821998004e-18,Conserved chromatin interdomain motifs,True,assigned_and_evaluated +2742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphohexomutase C-terminal substrate loop,False,no_term_above_threshold +2743,42054,15.989176,1.0,Radical SAM,interpro,87681,Iron-sulfur,0.75,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,15.0,632.3439393939394,8.708778353051357e-39,Radical SAM entry-region activation,True,assigned_too_few_test_positives +2744,88164,18.960152,0.9243164,Transposition,keyword,88164,Transposition,0.9243164,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.9834813499111901,0.12235465255284504,0.002215330084182543,,55.23089016235426,4.0,14.0,207.73867595818814,6.696317706055954e-09,Integrase TTGIP loop motif,True,assigned_and_evaluated +2745,48767,20.889446,0.9946289,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.97998047,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,20.0,0.0,1.0,OB/S1 ssNA-binding modules,True,assigned_too_few_test_positives +2746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-family sensory domains,False,no_term_above_threshold +2747,85656,18.974619,0.9453125,alpha/beta hydrolase,gene3d,88153,Transferase,0.67626953,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9776190476190476,0.07464018539599936,0.0031014621178555605,,24.066128348395793,0.0,18.0,0.0,1.0,Rossmann-like donor-binding helices,True,assigned_and_evaluated +2748,87326,41.64252,0.80078125,Coiled coil,keyword,87326,Coiled coil,0.80078125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8299991707782246,0.34407390318527004,0.03943287549844927,0.3146067415730337,8.72555954482196,18.0,18.0,12.607528018608585,3.905291109887263e-20,Heptad coiled-coil scaffolds,True,assigned_and_evaluated +2749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-acidic peptide-binding cage,False,no_term_above_threshold +2750,87882,16.596605,0.64746094,Palmitate,keyword,87882,Palmitate,0.64746094,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8194876351251295,0.22851862282405855,0.002658396101019052,0.16666666666666666,85.96108861898335,3.0,18.0,11.102607076350091,0.004033718502029921,N-terminal export/maturation segment,True,assigned_and_evaluated +2751,87409,19.03686,0.8129883,Dioxygenase,keyword,87409,Dioxygenase,0.8129883,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,13.0,16.0,227.4275234741784,2.1668730089978572e-29,Fe/2OG oxygenase catalytic core,True,assigned_too_few_test_positives +2752,49116,23.036129,0.97265625,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97265625,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9987566607460036,0.5333333333333333,0.002215330084182543,1.0,240.74666666666667,19.0,20.0,82.68605839416058,1.163776261464173e-35,Linker-biased solenoid activation,True,assigned_and_evaluated +2753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphomutase catalytic core loops,False,no_term_above_threshold +2754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPT16 GxE[F/Y]RD motif,False,no_term_above_threshold +2755,38873,16.653994,0.81152344,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7084961,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7956483126110124,0.2627908939384349,0.002215330084182543,0.4,118.62380952380953,8.0,9.0,152.28863346104725,2.723307108104146e-17,Sigma-54 EBP AAA+ linker,True,assigned_and_evaluated +2756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SMC/Rad50-like coiled-coil arms,False,no_term_above_threshold +2757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-domain helix-loop patches,False,no_term_above_threshold +2758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-region FxxQFY motif extended activation,False,no_term_above_threshold +2759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Luminal/periplasmic scaffolds and tails,False,no_term_above_threshold +2760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidoglycan enzyme domain-wide activation,False,no_term_above_threshold +2761,45290,24.619492,0.78125,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.78125,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7148978472507884,0.22222477057118883,0.0057598582188746125,0.15384615384615385,38.58163901378255,15.0,16.0,68.83582204433498,4.67155893575084e-27,Protein kinase catalytic loop,True,assigned_and_evaluated +2762,36499,20.003319,0.9951172,"Zinc finger, GATA-type",interpro,37071,Homeodomain,0.8725586,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,5.0,17.0,224.81523378582202,4.3972919249826416e-11,Cas9 PAM-interacting domain,True,assigned_too_few_test_positives +2763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and scaffolds,False,no_term_above_threshold +2764,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal/C-terminal transmembrane helices,False,no_term_above_threshold +2765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic recognition domains and tails,False,no_term_above_threshold +2766,46078,16.437706,0.9326172,Armadillo-like helical,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.92089844,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,0.0,14.0,0.0,1.0,Regular-Structure Hydrophobic Cores,True,assigned_too_few_test_positives +2767,49045,18.200813,0.9995117,Kelch-type beta propeller,interpro,63831,F-box-like domain superfamily,0.7792969,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,20.0,20.0,542.0090909090909,1.2783113950738657e-53,Glycine-rich propeller hairpins,True,assigned_too_few_test_positives +2768,64026,17.230976,0.9042969,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.82373047,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9122612172367837,0.016346548794393248,0.002658396101019052,,6.149026771490926,0.0,16.0,0.0,1.0,Loop–TM junction sensor,True,assigned_and_evaluated +2769,69990,16.36911,0.9428711,DNA/RNA polymerase superfamily,interpro,87856,Nucleotidyltransferase,0.7583008,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.7044444444444444,0.1085749851557814,0.0031014621178555605,,35.00767735665695,12.0,13.0,242.44391731616403,3.0837930239658993e-28,Polymerase boundary linker helices,True,assigned_and_evaluated +2770,47717,15.930455,0.9423828,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.71435547,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,14.0,0.0,1.0,Receiver domain switch loop,True,assigned_too_few_test_positives +2771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered linkers,False,no_term_above_threshold +2772,36449,21.629105,0.88378906,EamA domain,interpro,36449,EamA domain,0.88378906,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,16.0,0.0,1.0,DMT/EamA endomembrane metabolite antiporters,True,assigned_too_few_test_positives +2773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell wall glycan hydrolase cores,False,no_term_above_threshold +2774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal coiled-coils and tails,False,no_term_above_threshold +2775,45324,24.672169,0.94921875,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.94921875,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9980461811722913,0.3812698412698412,0.002215330084182543,1.0,172.10520634920633,16.0,16.0,546.9816513761467,8.086221761424609e-44,Secreted polysaccharide-degrading beta-solenoids,True,assigned_and_evaluated +2776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-dependent catalytic domains,False,no_term_above_threshold +2777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular enzyme regions,False,no_term_above_threshold +2778,64085,18.581186,0.7426758,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7368164,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.813577517144139,0.22507293365431208,0.012405848471422242,,18.14248611634937,0.0,12.0,0.0,1.0,SEMA/CNH beta-propeller detector,True,assigned_and_evaluated +2779,50338,16.043148,0.9248047,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8979492,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,13.0,0.0,1.0,Membrane glycosyltransferase interfacial loops,True,assigned_too_few_test_positives +2780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase motor domains,False,no_term_above_threshold +2781,36354,18.779375,0.94628906,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9238281,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,16.0,0.0,1.0,MORN repeat glycine hotspots,True,assigned_too_few_test_positives +2782,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored transmembrane hairpins,False,no_term_above_threshold +2783,36535,19.303728,0.984375,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9682617,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9945260347129505,0.8511216056670602,0.004430660168365086,0.8,192.0981463990555,17.0,17.0,89.79066265060241,2.357720211227094e-33,Kinase P-loop/beta3 hotspot,True,assigned_and_evaluated +2784,36449,18.543657,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,11.0,18.0,650.625992063492,2.0452433084799607e-29,Interhelical loop N cap motif,True,assigned_too_few_test_positives +2785,88009,16.55923,0.6191406,Repeat,keyword,88009,Repeat,0.6191406,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6246649691771643,0.12868271422360789,0.07266282676118742,,1.7709566219675792,11.0,20.0,4.876066914498142,4.487515676070656e-06,Disordered repeats and dibasic cleavage,True,assigned_and_evaluated +2786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1 juxtamembrane aromatic belt,False,no_term_above_threshold +2787,36876,17.351757,0.9995117,Cytochrome P450,interpro,36876,Cytochrome P450,0.9995117,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,17.0,389.6797385620915,6.157114732498076e-44,Cytochrome P450 catalytic core,True,assigned_and_evaluated +2788,36499,17.205292,0.9560547,"Zinc finger, GATA-type",interpro,29166,zinc ion binding,0.6245117,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,17.0,0.0,1.0,TF DBD-flanking terminal IDRs,True,assigned_too_few_test_positives +2789,38873,16.043364,0.9501953,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.86865234,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9950266429840143,0.46175438596491225,0.002215330084182543,0.4,208.4359298245614,10.0,10.0,171.32471264367817,1.12424031081604e-22,P-loop ATPase switch residues,True,assigned_and_evaluated +2790,85664,18.568817,0.98046875,Glycogen Phosphorylase B;,gene3d,59224,Alpha/Beta hydrolase fold,0.8701172,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase DxD acidic loop,True,assigned_too_few_test_positives +2791,87786,21.065678,0.6791992,Mitochondrion inner membrane,keyword,87786,Mitochondrion inner membrane,0.6791992,163,keywords,Mitochondrion inner membrane,keyword:keywords:Mitochondrion inner membrane,15.0,2257.0,0.7182277728218852,0.09926325385341779,0.00664599025254763,,14.93581092981093,0.0,18.0,0.0,1.0,Hydrophobic topogenic membrane helices,True,assigned_and_evaluated +2792,72011,18.15477,0.9897461,"AMP-binding enzyme, C-terminal domain superfamily",interpro,37894,Short-chain dehydrogenase/reductase SDR,0.98046875,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,10.0,0.0,1.0,SDR pre-Tyr loop-helix junction,True,assigned_too_few_test_positives +2793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Endolysosomal trafficking machinery,False,no_term_above_threshold +2794,85364,20.073303,0.73876953,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.73876953,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,19.0,206.02684742158428,3.6533632046702945e-28,PBP hinge/lid loop,True,assigned_too_few_test_positives +2795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post signal periplasmic N termini,False,no_term_above_threshold +2796,72011,16.068655,0.84521484,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.77441406,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,DNA repair N-terminal activation,True,assigned_too_few_test_positives +2797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged nucleic-acid-binding surfaces,False,no_term_above_threshold +2798,66234,17.928453,0.9604492,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.9604492,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,14.0,16.0,207.0173611111111,1.973254152064377e-31,Gly-rich Cys-His catalytic loop,True,assigned_too_few_test_positives +2799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-TM luminal interface loops,False,no_term_above_threshold +2800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic AS_C helix,False,no_term_above_threshold +2801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal alpha-helical regions,False,no_term_above_threshold +2802,47529,27.073738,0.9868164,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9868164,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9975875725122714,0.6543631654535916,0.007089056269384138,0.875,92.30610402679727,19.0,20.0,73.46297016861219,1.0504096158872857e-34,Extracellular beta-sandwich loop interfaces,True,assigned_and_evaluated +2803,64085,17.697731,0.8959961,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8935547,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9275780298660514,0.07647913534036173,0.012405848471422242,,6.164764587971301,0.0,19.0,0.0,1.0,Local β-strand/hairpin segments,True,assigned_and_evaluated +2804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged short helix motif,False,no_term_above_threshold +2805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,E2/UEV core and backside mimetics,False,no_term_above_threshold +2806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted surface beta strands,False,no_term_above_threshold +2807,87991,18.554651,0.85498047,Pyrrolidone carboxylic acid,keyword,87991,Pyrrolidone carboxylic acid,0.85498047,223,keywords,Pyrrolidone carboxylic acid,keyword:keywords:Pyrrolidone carboxylic acid,11.0,2257.0,0.7960819234194123,0.0757958132419204,0.004873726185201595,0.09090909090909091,15.55192277154676,5.0,19.0,31.37947368421052,8.324805593161451e-07,Glutamine residue identity detector,True,assigned_and_evaluated +2808,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad extracellular beta-strand activation,False,no_term_above_threshold +2809,87276,29.004776,0.6088867,Cell membrane,keyword,87276,Cell membrane,0.6088867,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.705438465480054,0.42050448044848626,0.11120957022596367,0.450199203187251,3.7811896907260296,12.0,18.0,5.470318377832829,1.9063299488550125e-07,N-terminal signal-anchor transmembrane helix,True,assigned_and_evaluated +2810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Porphobilinogen synthase WRHG loop motif,False,no_term_above_threshold +2811,38317,21.200367,0.9995117,Pentatricopeptide repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99121094,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9990476190476191,0.8468864468864468,0.0031014621178555605,0.7142857142857143,273.06038723181575,13.0,19.0,263.18268251273344,1.4684224419135107e-29,PPR/ankyrin repeat register detector,True,assigned_and_evaluated +2812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding glycine-rich loops,False,no_term_above_threshold +2813,36115,20.566484,0.8671875,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8623047,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,16.0,0.0,1.0,Polyprenol donor-binding TM helix,True,assigned_too_few_test_positives +2814,72011,17.9041,0.99902344,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.94189453,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,13.0,18.0,426.33278327832784,1.5748002227917863e-32,Sulfatase-like LTA/PGT catalytic domain,True,assigned_too_few_test_positives +2815,88164,16.445656,0.71484375,Transposition,keyword,88164,Transposition,0.71484375,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.6915630550621669,0.12037681709812859,0.002215330084182543,0.2,54.33809523809525,0.0,13.0,0.0,1.0,RNase H catalytic domain,True,assigned_and_evaluated +2816,85675,20.58892,0.94970703,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.92822266,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,19.0,19.0,546.9816513761467,4.1212564759828525e-51,ITIH VIT domain signature,True,assigned_too_few_test_positives +2817,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered low-complexity tracts,False,no_term_above_threshold +2818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic PG-rich low-complexity linkers,False,no_term_above_threshold +2819,63951,16.613468,0.9741211,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9711914,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.987495057334915,0.353916049750878,0.003987594151528578,0.3333333333333333,88.75428047641462,3.0,17.0,28.43608903020668,0.00027417287071023795,Hydrophobic beta-strand core signal,True,assigned_and_evaluated +2820,47529,16.364925,0.69628906,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.69628906,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6381916555109326,0.02613664327012955,0.007089056269384138,,3.6869002412926495,0.0,20.0,0.0,1.0,Outer-membrane beta-barrel strand detector,True,assigned_and_evaluated +2821,88058,37.6258,0.64990234,Signal,keyword,88058,Signal,0.64990234,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7000338456731976,0.19669056823369196,0.09127159946832078,,2.1550029733176834,2.0,19.0,0.7584162823978374,1.0,Extracytoplasmic STP-rich linkers,True,assigned_and_evaluated +2822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central helix-strand acidic-hydrophobic motif,False,no_term_above_threshold +2823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Organelle membrane-proximal acidic disorder,False,no_term_above_threshold +2824,64585,16.324213,0.9980469,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.9868164,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,14.0,17.0,557.9505347593582,3.3340182359258227e-37,RNA metabolism effector IDRs,True,assigned_too_few_test_positives +2825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Y-family PAD alpha-helix,False,no_term_above_threshold +2826,37690,22.255219,0.96533203,Ankyrin repeat,interpro,88009,Repeat,0.7475586,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9838730158730158,0.2443658795712048,0.0031014621178555605,0.14285714285714285,78.7905414560299,4.0,12.0,60.22323232323232,8.540289255270607e-07,Leucine-rich repeat core motif,True,assigned_and_evaluated +2827,72011,18.986328,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9609375,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,12.0,13.0,544.898705255141,1.6074198959908036e-32,ANL adenylation active-site loops,True,assigned_too_few_test_positives +2828,50338,20.685741,0.9711914,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.87109375,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,20.0,0.0,1.0,Post-transmembrane extracytoplasmic helix,True,assigned_too_few_test_positives +2829,85791,20.278652,0.7583008,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.7583008,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,14.0,0.0,1.0,Amidotransferase coupling interface,True,assigned_too_few_test_positives +2830,36776,16.745768,0.9746094,SANT/Myb domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9399414,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9831186139493558,0.08016960862293318,0.002658396101019052,,30.15713444366003,0.0,17.0,0.0,1.0,HTH helix-turn junction,True,assigned_and_evaluated +2831,38873,19.290108,0.8725586,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.82714844,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7929840142095915,0.15488613203367302,0.002215330084182543,,69.91560000000001,14.0,15.0,159.90306513409962,2.354085876269867e-30,P-loop NTPase pore-loop engagement,True,assigned_and_evaluated +2832,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-metal nuclease cores,False,no_term_above_threshold +2833,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble membrane protein appendages,False,no_term_above_threshold +2834,81858,17.89688,0.8305664,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8305664,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,4.0,16.0,65.37390350877193,7.106048191973487e-07,Disordered cytosolic C-terminal tail,True,assigned_too_few_test_positives +2835,85364,26.02206,0.9008789,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9008789,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,17.0,230.2653000594177,3.4121910281845893e-29,LysR effector-binding helix,True,assigned_too_few_test_positives +2836,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid-binding recognition surfaces,False,no_term_above_threshold +2837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass membrane transporter signature,False,no_term_above_threshold +2838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FIC-domain C-terminal helix,False,no_term_above_threshold +2839,43624,15.90863,0.7519531,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.7519531,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.6609075189647479,0.01866152191970468,0.007089056269384138,,2.6324409357983414,0.0,14.0,0.0,1.0,Internal sulfatase catalytic motif,True,assigned_and_evaluated +2840,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage tailspike depolymerases,False,no_term_above_threshold +2841,87326,32.70172,0.6928711,Coiled coil,keyword,87326,Coiled coil,0.6928711,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7182304407313737,0.27543788721648327,0.03943287549844927,0.33707865168539325,6.984981027501155,14.0,19.0,9.2897574873958,6.607499695334387e-12,Proline-directed phospho-regulatory IDRs,True,assigned_and_evaluated +2842,87276,40.047558,0.6791992,Cell membrane,keyword,88161,Transmembrane helix,0.66552734,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7382464161300958,0.4727263912552285,0.11120957022596367,0.5219123505976095,4.250770777143628,15.0,16.0,7.692635218827416,6.058947411148528e-13,Multi-pass transmembrane helix detector,True,assigned_and_evaluated +2843,48241,17.048565,0.9711914,RmlC-like jelly roll fold,interpro,87697,Knottin,0.88623047,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,0.0,18.0,0.0,1.0,Beta-strand N-cap turn detector,True,assigned_too_few_test_positives +2844,85649,19.074898,0.9067383,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.9067383,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8962769063096026,0.1371891857188584,0.0101905183872397,0.043478260869565216,13.462434442063627,0.0,15.0,0.0,1.0,Active-site capping loop,True,assigned_and_evaluated +2845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical signalosome adaptor domains,False,no_term_above_threshold +2846,27735,16.452902,0.74853516,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,87326,Coiled coil,0.7348633,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.7181584663655484,0.12003461504310825,0.011519716437749225,,10.419927928934435,1.0,17.0,2.660939034187271,0.49445613007239325,Coiled-coil e/g charged stripes,True,assigned_and_evaluated +2847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytochrome c heme-edge docking,False,no_term_above_threshold +2848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease periplasmic hydrophobic-basic motif,False,no_term_above_threshold +2849,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass membrane helix pairs,False,no_term_above_threshold +2850,59229,39.455654,0.98291016,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98291016,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8666848312638666,0.7393733719464296,0.0101905183872397,0.7391304347826086,72.55503045578659,14.0,14.0,106.27629233511585,1.2612068461381496e-28,7BS MTase N-terminal loop,True,assigned_and_evaluated +2851,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease and phosphodiesterase catalytic cores,False,no_term_above_threshold +2852,59224,16.095573,0.68115234,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.68115234,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7714285714285714,0.07512592633256232,0.0031014621178555605,,24.222745104656166,0.0,18.0,0.0,1.0,Extracytoplasmic ligand binding hinge loop,True,assigned_and_evaluated +2853,87697,18.414038,0.8286133,Knottin,keyword,87413,Disulfide bond,0.7182617,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9681741462625141,0.20196118295684068,0.017279574656623838,,11.687856152143318,0.0,18.0,0.0,1.0,Disulfide-rich extracellular domains,True,assigned_and_evaluated +2854,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short surface interaction patches,False,no_term_above_threshold +2855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil tethers,False,no_term_above_threshold +2856,85664,16.1171,0.8515625,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7597656,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,N-terminal Gly/Pro ATP-binding loop,True,assigned_too_few_test_positives +2857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zn-dependent peptidase ectodomains,False,no_term_above_threshold +2858,46277,24.73636,0.98291016,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.98291016,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9929167003966648,0.49424071424071425,0.004873726185201595,0.45454545454545453,101.40920836739019,13.0,16.0,152.81407728706625,3.8367161870103224e-27,Aromatic base-stacking beta strand,True,assigned_and_evaluated +2859,63774,16.063131,0.93896484,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.93896484,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,2.0,16.0,22.86081288343558,0.005876855828320721,Hydrophobic helical packing surfaces,True,assigned_too_few_test_positives +2860,52940,17.351849,0.94384766,"AMP-binding, conserved site",interpro,85682,NAD(P)-binding Rossmann-like Domain,0.78564453,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,15.0,0.0,1.0,Rossmann phosphate–ribose binding loop,True,assigned_too_few_test_positives +2861,25169,17.3265,0.73583984,pilus,go_cc,25169,pilus,0.73583984,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7964476021314387,0.44088613203367305,0.002215330084182543,0.4,199.01600000000002,1.0,12.0,46.003858024691354,0.036199068281376375,Helix caps and interfacial anchors,True,assigned_and_evaluated +2862,88058,17.900703,0.6040039,Signal,keyword,88058,Signal,0.6040039,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5944803150724486,0.11312773063485748,0.09127159946832078,,1.2394625633149192,5.0,20.0,1.801238670694864,0.21355299572385222,Glycine polar turn signature,True,assigned_and_evaluated +2863,88009,20.633793,0.6328125,Repeat,keyword,88009,Repeat,0.6328125,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7593633831703821,0.26554744842307487,0.07266282676118742,0.3597560975609756,3.654515799334634,12.0,18.0,5.910384138785625,8.017605135019945e-08,Clp N-terminal repeat domain,True,assigned_and_evaluated +2864,72011,19.57817,0.98779297,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.95947266,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,Nucleotidyltransferase N-terminal disordered regions,True,assigned_too_few_test_positives +2865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical tRNA-sensing appendages,False,no_term_above_threshold +2866,63960,16.978,0.6669922,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.6669922,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,16.0,16.0,193.57467532467533,1.0288461071936617e-36,FAD-dependent oxygenase/oxidase domain,True,assigned_too_few_test_positives +2867,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide/metal-dependent catalytic modules,False,no_term_above_threshold +2868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-wall glycan-active enzymes,False,no_term_above_threshold +2869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-to-loop transition hinge,False,no_term_above_threshold +2870,58239,25.722807,0.6323242,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6323242,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6839027965719441,0.30446129111672393,0.017722640673460344,0.35,17.17922835126115,15.0,15.0,35.851473241130485,1.3063198800490947e-23,Switch-coupling helices,True,assigned_and_evaluated +2871,59229,41.594463,0.8378906,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8378906,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.821192246311938,0.5254716282050971,0.0101905183872397,0.5217391304347826,51.56475934169148,17.0,17.0,106.27629233511585,1.3819031749869367e-34,Methyltransferase SAM-binding core,True,assigned_and_evaluated +2872,87714,16.606077,0.60839844,Lectin,keyword,87714,Lectin,0.60839844,89,keywords,Lectin,keyword:keywords:Lectin,7.0,2257.0,0.5655238095238094,0.009151902594525545,0.0031014621178555605,,2.9508348794063077,5.0,15.0,71.23178016726403,1.2639384434005319e-08,Trp-rich beta-propeller binding surfaces,True,assigned_and_evaluated +2873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-centered HDAC-like signature,False,no_term_above_threshold +2874,49121,18.460579,0.8925781,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.8925781,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,8.0,10.0,781.9147540983607,9.389191163481189e-23,HTH-flanking helix-coil linkers,True,assigned_too_few_test_positives +2875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible β-edge connector patches,False,no_term_above_threshold +2876,66234,19.928707,0.90722656,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.90722656,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,13.0,15.0,205.04576719576718,3.782172370222879e-29,Cys-protease-like active-site flank,True,assigned_too_few_test_positives +2877,37894,25.35329,0.9760742,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7138672,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,9.0,552.0462962962963,7.712822084981217e-19,SDR Rossmann oxidoreductase core,True,assigned_too_few_test_positives +2878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted amphipathic helices,False,no_term_above_threshold +2879,46082,16.074558,0.93603516,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.93603516,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9960634920634921,0.41429789307027154,0.0031014621178555605,0.5714285714285714,133.5814778085147,15.0,18.0,125.78270042194094,4.83004484071084e-30,Acidic Pro/Ser/Thr-rich IDR tails,True,assigned_and_evaluated +2880,43583,18.653404,0.9692383,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9692383,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,14.0,15.0,389.1347319347319,8.857790808758203e-36,Serine protease catalytic Asp,True,assigned_and_evaluated +2881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-proximal polar cores,False,no_term_above_threshold +2882,85649,30.598928,0.75439453,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7495117,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8237320462418747,0.5959222114734737,0.0101905183872397,0.6521739130434783,58.47810570850565,17.0,17.0,110.61410018552876,7.110790058883305e-35,Class I MTase catalytic core,True,assigned_and_evaluated +2883,87697,16.548826,0.75390625,Knottin,keyword,87413,Disulfide bond,0.6254883,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8636852327113823,0.07173478047339807,0.017279574656623838,,4.151420500729729,0.0,15.0,0.0,1.0,Extracellular glycan-binding surfaces,True,assigned_and_evaluated +2884,49061,17.515356,0.84277344,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.84277344,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8591376658334936,0.04527843676582379,0.012405848471422242,,3.649765420730868,0.0,17.0,0.0,1.0,Beta-strand capping residues,True,assigned_and_evaluated +2885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLH domain triad,False,no_term_above_threshold +2886,38317,17.435783,0.7963867,Pentatricopeptide repeat,interpro,87882,Palmitate,0.78125,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8860634920634921,0.014309892809919149,0.0031014621178555605,,4.613918295998217,0.0,11.0,0.0,1.0,Polar active-site loop motifs,True,assigned_and_evaluated +2887,82029,22.568264,0.98339844,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6694336,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Transporter transmembrane core helices,True,assigned_too_few_test_positives +2888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved functional site signal,False,no_term_above_threshold +2889,37312,19.61074,0.9975586,"DNA-binding HTH domain, TetR-type",interpro,37312,"DNA-binding HTH domain, TetR-type",0.9975586,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,14.0,0.0,1.0,Flavin-interface beta-loop-alpha segment,True,assigned_too_few_test_positives +2890,28025,18.71248,0.9277344,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.7236328,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9957796534873389,0.6366550116550116,0.002658396101019052,0.6666666666666666,239.4883935508935,12.0,16.0,203.2534090909091,2.6795217530725517e-26,P-loop NTPase Switch II,True,assigned_and_evaluated +2891,49061,32.461178,0.9819336,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9819336,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.99718002948151,0.6824463344649234,0.012405848471422242,1.0,55.010049174547575,11.0,20.0,54.380679933665014,3.903430949904748e-17,Eukaryotic propeller scaffold interfaces,True,assigned_and_evaluated +2892,47529,16.680977,0.6503906,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6503906,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7444779116465864,0.21232797283578647,0.007089056269384138,0.1875,29.95151466814813,14.0,15.0,72.17414613056637,1.4895718074093658e-25,S/T/P/G-rich beta-sandwich linkers,True,assigned_and_evaluated +2893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil docking helix,False,no_term_above_threshold +2894,88161,32.97681,0.66845703,Transmembrane helix,keyword,88161,Transmembrane helix,0.66845703,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6852276874152853,0.381085512780605,0.1847585290208241,0.2733812949640288,2.0626139144983826,11.0,12.0,4.975201031709908,1.6254408560583877e-07,Membrane helix boundary anchors,True,assigned_and_evaluated +2895,27918,15.814227,0.75097656,DNA-binding transcription factor activity,go_mf,87384,DNA-binding,0.7133789,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.6988457279154954,0.018184405601260695,0.00930438635356668,,1.9543906400973996,5.0,20.0,9.252172563625079,0.00028673825571739884,Motif-and-repeat sequence detector,True,assigned_and_evaluated +2896,85649,18.06479,0.8198242,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.8198242,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7856642403954691,0.03219026566813599,0.0101905183872397,,3.158844765781866,0.0,10.0,0.0,1.0,Basic amphipathic binding helices,True,assigned_and_evaluated +2897,36668,21.60453,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.98583984,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,15.0,15.0,532.3303571428571,4.765377825901055e-41,ANL active-site lid/loop,True,assigned_too_few_test_positives +2898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich active-site gating loops,False,no_term_above_threshold +2899,36104,19.18729,0.99853516,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99853516,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Active-site cap/linker segment,True,assigned_too_few_test_positives +2900,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-binding sensory beta-strand motif,False,no_term_above_threshold +2901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted N-terminal assembly/adhesion segments,False,no_term_above_threshold +2902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar β-rich accessory regions,False,no_term_above_threshold +2903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-lined ligand-binding pockets,False,no_term_above_threshold +2904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble beta-sheet cores,False,no_term_above_threshold +2905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved repeat core residues,False,no_term_above_threshold +2906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal acidic helical segments,False,no_term_above_threshold +2907,63951,21.23636,0.9433594,Immunoglobulin-like domain superfamily,interpro,87413,Disulfide bond,0.68359375,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9830960854092526,0.44452787266744725,0.003987594151528578,0.4444444444444444,111.4777120678254,14.0,14.0,161.13783783783785,3.975102145623941e-31,IgSF ectodomain activation,True,assigned_and_evaluated +2908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sandwich carbohydrate-recognition domains,False,no_term_above_threshold +2909,88150,19.543718,0.6171875,Transcription regulation,keyword,88150,Transcription regulation,0.6171875,1201,keywords,Transcription regulation,keyword:keywords:Transcription regulation,122.0,2257.0,0.6147560179675203,0.17536108337230136,0.05405405405405406,0.14754098360655737,3.244180042387575,6.0,20.0,3.58802407221665,0.008130618290120122,PTM-rich low-complexity IDRs,True,assigned_and_evaluated +2910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ECF T-component C-terminal coupling region,False,no_term_above_threshold +2911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization stalks,False,no_term_above_threshold +2912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich transmembrane helix motif,False,no_term_above_threshold +2913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-anchor ectodomain beta-loops,False,no_term_above_threshold +2914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro metal-binding loops,False,no_term_above_threshold +2915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine-rich regulatory IDRs,False,no_term_above_threshold +2916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretion-targeting coiled-coil hairpins,False,no_term_above_threshold +2917,61392,18.697302,0.8979492,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.8979492,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9819682539682539,0.0985413977503227,0.0031014621178555605,,31.77256210321119,0.0,16.0,0.0,1.0,Extracellular β-solenoid/β-helix scaffolds,True,assigned_and_evaluated +2918,49230,22.125458,0.76171875,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.76171875,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,14.0,18.0,218.73532494758908,4.062899256202499e-31,Amide-forming acyltransferase core,True,assigned_too_few_test_positives +2919,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OmpA-like peptidoglycan-binding proteins,False,no_term_above_threshold +2920,85672,22.003807,0.63671875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.62841797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6850017509630296,0.19402718568216182,0.01595037660611431,0.2222222222222222,12.1644266134622,14.0,14.0,40.01409395973155,9.778128717856954e-23,Amphipathic C-terminal interface helices,True,assigned_and_evaluated +2921,50338,17.395103,0.85302734,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.85302734,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Metal-binding catalytic transmembrane helices,True,assigned_too_few_test_positives +2922,36115,16.429241,0.7944336,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.78759766,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,15.0,0.0,1.0,Amphipathic recognition helices,True,assigned_too_few_test_positives +2923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved polar downstream cofactor segment,False,no_term_above_threshold +2924,85656,27.751873,0.9897461,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.9892578,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,18.0,18.0,141.281990521327,9.999057839062593e-39,Alpha/beta-hydrolase active-site loops,True,assigned_and_evaluated +2925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal PDHRPK-like motif,False,no_term_above_threshold +2926,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed alpha-helices,False,no_term_above_threshold +2927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure anchor residues,False,no_term_above_threshold +2928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor module,False,no_term_above_threshold +2929,37341,22.633245,0.9941406,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9790039,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999833914632121,0.9986772486772486,0.011962782454585734,1.0,83.48202038016852,19.0,19.0,145.4170731707317,5.254240088122417e-41,WD40 blade junction linkers,True,assigned_and_evaluated +2930,64058,20.155191,0.6645508,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6616211,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8394051334309918,0.07623087790575,0.006202924235711121,,12.289506530948412,6.0,12.0,56.99904397705544,8.119325085244014e-10,Beta-decarboxylating dehydrogenase catalytic loop,True,assigned_and_evaluated +2931,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular fibrinogen and gC1q domains,False,no_term_above_threshold +2932,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short secondary structure scaffold,False,no_term_above_threshold +2933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MCP helix-face gly/ala motif,False,no_term_above_threshold +2934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PI-PLC Y-box activation,False,no_term_above_threshold +2935,82029,23.486885,0.99902344,MFS general substrate transporter like domains,gene3d,63831,F-box-like domain superfamily,0.9550781,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,19.0,168.2810891582268,1.3975966628625714e-36,Membrane-helix interface residues,True,assigned_too_few_test_positives +2936,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface beta-loop interface patch,False,no_term_above_threshold +2937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ub/UBL cysteine proteases,False,no_term_above_threshold +2938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Archaeal PolC KRR arginine,False,no_term_above_threshold +2939,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic membrane-exit helices,False,no_term_above_threshold +2940,87413,53.42868,0.8745117,Disulfide bond,keyword,87413,Disulfide bond,0.8745117,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.8786705559975251,0.2933005058205195,0.0717766947275144,0.05555555555555555,4.086291615042669,10.0,20.0,5.913608411029558,2.9531344426302513e-06,Surface-exposed cysteine/disulfide signal,True,assigned_and_evaluated +2941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted propeptide/leader region,False,no_term_above_threshold +2942,63951,21.207619,0.96728516,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9614258,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9961200079082642,0.43379240585122936,0.003987594151528578,0.1111111111111111,108.78549555624718,6.0,18.0,53.71261261261261,1.9660388080821e-09,Ig-like/FN3 beta-strand peaks,True,assigned_and_evaluated +2943,36876,17.978107,1.0,Cytochrome P450,interpro,69093,"ANL, N-terminal domain",0.9423828,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,389.6797385620915,2.4234264751426887e-46,Cytochrome P450 catalytic-core helices,True,assigned_and_evaluated +2944,58239,15.795298,0.6689453,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6689453,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.5718369418132612,0.04537789230280671,0.017722640673460344,0.05,2.560447573185869,0.0,17.0,0.0,1.0,Noncatalytic hydrophobic interface patch,True,assigned_and_evaluated +2945,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed secreted domains,False,no_term_above_threshold +2946,85364,16.113472,0.72558594,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.72558594,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,0.0,18.0,0.0,1.0,Dockerin cohesin-binding helices,True,assigned_too_few_test_positives +2947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic DNA-binding domains,False,no_term_above_threshold +2948,36776,17.65034,0.94873047,SANT/Myb domain,interpro,47529,Immunoglobulin-like fold,0.8598633,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.988005330964016,0.1103252094986375,0.002658396101019052,,41.500666306404135,0.0,19.0,0.0,1.0,Conserved repeated beta-strand motif,True,assigned_and_evaluated +2949,72011,16.473064,0.83203125,"AMP-binding enzyme, C-terminal domain superfamily",interpro,87913,Phosphopantetheine,0.79833984,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Nudix/IDI N-terminal beta1-loop,True,assigned_too_few_test_positives +2950,72011,15.718897,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9213867,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,11.0,11.0,590.3069306930694,7.405995892647381e-31,AMP-binding C-terminal beta-strand motif,True,assigned_too_few_test_positives +2951,85682,15.820882,0.6557617,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6557617,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7541935483870968,0.2502870127743047,0.011076650420912717,0.08,22.595911513264227,2.0,17.0,12.031278377560286,0.02003992495362323,C-terminal catalytic subdomain,True,assigned_and_evaluated +2952,37894,19.196056,0.9355469,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9355469,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Histidine kinase ATP-lid helix,True,assigned_too_few_test_positives +2953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible domain-boundary linkers,False,no_term_above_threshold +2954,52236,19.418999,0.99316406,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98779297,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,13.0,17.0,170.75853712271422,1.692590356210517e-27,TPR/PCI helix-capping detector,True,assigned_too_few_test_positives +2955,39971,17.424152,0.98535156,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,85664,Glycogen Phosphorylase B;,0.96875,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,Acidic donor-binding glycosyltransferase loop,True,assigned_too_few_test_positives +2956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged nucleic-acid channel clamps,False,no_term_above_threshold +2957,87489,22.055233,0.77734375,GPI-anchor,keyword,87489,GPI-anchor,0.77734375,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.6309523809523809,0.161879195630401,0.0031014621178555605,0.14285714285714285,52.19447779111644,15.0,18.0,122.6769547325103,6.99778407804265e-30,Fungal extracellular mucin-like IDRs,True,assigned_and_evaluated +2958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed polar low-complexity regions,False,no_term_above_threshold +2959,36776,17.641314,0.99560547,SANT/Myb domain,interpro,80926,Homeodomain-like,0.77685547,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9990374648304458,0.6716269841269841,0.002658396101019052,1.0,252.64368386243382,14.0,16.0,278.97526737967917,2.9836692422414154e-33,Myb/SANT HTH and IDRs,True,assigned_and_evaluated +2960,85656,17.73209,0.9277344,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7788086,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8998412698412699,0.03353347777274236,0.0031014621178555605,,10.812151333297074,1.0,17.0,8.31070532478394,0.1832328223613001,Helix N-cap pocket hotspots,True,assigned_and_evaluated +2961,47529,28.715918,0.9819336,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9819336,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9955795403837573,0.5591689695891733,0.007089056269384138,0.75,78.87777277267276,16.0,19.0,65.11953034336815,1.6340624439516e-27,Extracellular beta-strand edge motifs,True,assigned_and_evaluated +2962,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic nucleic acid catalytic cores,False,no_term_above_threshold +2963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix capping/hinge motif,False,no_term_above_threshold +2964,85649,41.719494,0.86621094,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.86621094,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9310945467284262,0.48121347534542236,0.0101905183872397,0.8695652173913043,47.22168755889644,0.0,13.0,0.0,1.0,Terminal accessory regulatory regions,True,assigned_and_evaluated +2965,37468,20.11163,0.97509766,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.9160156,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,20.0,0.0,1.0,Cys/His-rich loop motifs,True,assigned_too_few_test_positives +2966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metallocarboxypeptidase active-site loops,False,no_term_above_threshold +2967,47529,26.512167,0.94970703,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.94970703,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9873382418563141,0.21656926058758008,0.007089056269384138,,30.549801321635517,4.0,19.0,16.27988258584204,0.00016806245289597164,Extracellular domain peak clusters,True,assigned_and_evaluated +2968,63960,23.630615,0.73535156,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.73535156,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,11.0,15.0,141.95476190476188,2.1668682902593636e-22,Flexible C-terminal enzyme tails,True,assigned_too_few_test_positives +2969,27936,18.000473,0.8203125,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.8203125,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,12.0,12.0,641.0860215053764,4.7818218269691484e-34,Prolyl isomerase catalytic surface,True,assigned_too_few_test_positives +2970,88058,46.204746,0.6425781,Signal,keyword,88058,Signal,0.6425781,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7021722768434058,0.4443978997511767,0.09127159946832078,0.441747572815534,4.868961455040805,16.0,18.0,6.404404162470628,4.7205252765143645e-12,Secretory signal and propeptides,True,assigned_and_evaluated +2971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alternating beta strands,False,no_term_above_threshold +2972,87413,20.449203,0.6269531,Disulfide bond,keyword,87413,Disulfide bond,0.6269531,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6092268481687735,0.09531698213186086,0.0717766947275144,,1.3279656090840122,2.0,19.0,1.2449701917956963,0.7551009893139149,Beta-strand loop connectors,True,assigned_and_evaluated +2973,46933,16.732958,0.9794922,"Zinc finger, NHR/GATA-type",interpro,29166,zinc ion binding,0.78125,49,ip,IPR013088,interpro:ip:IPR013088,,,,,,,,0.0,16.0,0.0,1.0,Cys/His zinc-finger mini-domains,True,assigned_too_few_test_positives +2974,82029,24.59869,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,TM helix boundary/hinge residues,True,assigned_too_few_test_positives +2975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal catalytic core segment,False,no_term_above_threshold +2976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible allosteric interface hinges,False,no_term_above_threshold +2977,45289,16.02203,0.8256836,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.8256836,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,0.0,17.0,0.0,1.0,Acidic periplasmic helix N-caps,True,assigned_too_few_test_positives +2978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NDK/NME domain-wide activation,False,no_term_above_threshold +2979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core structural signal,False,no_term_above_threshold +2980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular and lumenal receptor-binding modules,False,no_term_above_threshold +2981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass extracellular ectodomains and loops,False,no_term_above_threshold +2982,85664,19.158619,0.9589844,Glycogen Phosphorylase B;,gene3d,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.93896484,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,16.0,16.0,331.22777777777776,2.1521342125337958e-40,Glycosyltransferase C-terminal cap helix,True,assigned_too_few_test_positives +2983,36668,18.819662,0.9848633,AMP-dependent synthetase/ligase domain,interpro,36668,AMP-dependent synthetase/ligase domain,0.9848633,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,20.0,0.0,1.0,Polar nucleic acid interfaces,True,assigned_too_few_test_positives +2984,82029,23.643538,0.9995117,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.64160156,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,MFS transmembrane helix boundaries,True,assigned_too_few_test_positives +2985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity tethering tails,False,no_term_above_threshold +2986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic enzyme alpha-helices,False,no_term_above_threshold +2987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix-to-loop segments,False,no_term_above_threshold +2988,85649,35.143845,0.9819336,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97558594,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8877914444747187,0.7786128456121328,0.0101905183872397,0.782608695652174,76.40561706724277,19.0,19.0,110.61410018552876,7.972136883844738e-39,SAM-binding motif I loop,True,assigned_and_evaluated +2989,47529,17.571505,0.796875,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.796875,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8189006024096386,0.19491431441120965,0.007089056269384138,0.25,27.49510047663126,17.0,20.0,65.73002594033723,2.6616462540944853e-29,Tyrosine-centered FN3/Ig beta-strand motif,True,assigned_and_evaluated +2990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine phosphotransfer coiled-coils,False,no_term_above_threshold +2991,72011,16.092102,0.99609375,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85656,alpha/beta hydrolase,0.8330078,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,19.0,0.0,1.0,Nucleotide-sugar donor-binding helix,True,assigned_too_few_test_positives +2992,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal functional extensions,False,no_term_above_threshold +2993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal extracellular ectodomains,False,no_term_above_threshold +2994,64596,31.057024,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,15.0,15.0,614.6494845360825,5.269182503336926e-42,Active-site rim cap/insert,True,assigned_too_few_test_positives +2995,82029,22.62733,0.99853516,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7080078,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,16.0,176.32393533123027,3.987569342785294e-33,Pseudo-symmetric TM pore-lining hydrophobics,True,assigned_too_few_test_positives +2996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site flanking alpha helices,False,no_term_above_threshold +2997,37071,18.876814,0.9189453,Homeodomain,interpro,37071,Homeodomain,0.9189453,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,9.0,0.0,1.0,Beta-strand core scaffold,True,assigned_too_few_test_positives +2998,85649,16.604784,0.6176758,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.6176758,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6707309952901794,0.31118360239885545,0.0101905183872397,0.34782608695652173,30.536582200618117,11.0,18.0,67.59750566893425,2.231275617351962e-18,Charged domain-edge linkers,True,assigned_and_evaluated +2999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic N-terminal POTRA/TonB-box,False,no_term_above_threshold +3000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal basic amphipathic helix,False,no_term_above_threshold +3001,36091,16.574217,0.8520508,GNAT domain,interpro,36091,GNAT domain,0.8520508,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,17.0,0.0,1.0,REC alpha4 output surface,True,assigned_too_few_test_positives +3002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal secretome-domain marker,False,no_term_above_threshold +3003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ero1 FAD-binding NPER motif,False,no_term_above_threshold +3004,88058,19.54067,0.62158203,Signal,keyword,88058,Signal,0.62158203,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6010624701187675,0.10464558567420823,0.09127159946832078,,1.1465295478965436,4.0,19.0,1.5168325647956749,0.4167641580369206,Low-complexity small polar detector,True,assigned_and_evaluated +3005,88160,19.141653,0.81640625,Transmembrane beta strand,keyword,25167,cell outer membrane,0.67871094,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,15.0,20.0,217.06674757281553,4.918941918535223e-33,β-barrel C-terminal signal,True,assigned_too_few_test_positives +3006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyproline-helix interface module,False,no_term_above_threshold +3007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like adenine-binding BA motif,False,no_term_above_threshold +3008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short mixed-composition windows,False,no_term_above_threshold +3009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal arginine binding patch,False,no_term_above_threshold +3010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved cysteines and core hydrophobics,False,no_term_above_threshold +3011,37690,21.043182,0.95947266,Ankyrin repeat,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.88378906,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9411111111111111,0.031092928450263835,0.0031014621178555605,,10.025248501749354,0.0,18.0,0.0,1.0,Alpha-helical interaction surfaces,True,assigned_and_evaluated +3012,25169,23.73363,0.89501953,pilus,go_cc,25169,pilus,0.89501953,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8884103019538188,0.08262134750546282,0.002215330084182543,,37.29527626396592,0.0,16.0,0.0,1.0,C-terminal tips and acidic tails,True,assigned_and_evaluated +3013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-enriched loop/edge residues,False,no_term_above_threshold +3014,45324,17.64656,0.96875,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.96875,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9981349911190054,0.3938888888888889,0.002215330084182543,1.0,177.80144444444446,1.0,15.0,36.46544342507645,0.04523480388969187,Beta-solenoid hydrophobic rungs,True,assigned_and_evaluated +3015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT-biased metalloenzyme beta-loop,False,no_term_above_threshold +3016,38873,16.176506,0.7089844,AAA+ ATPase domain,interpro,30398,ATP hydrolysis activity,0.65966797,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.997069271758437,0.34417151475975005,0.002215330084182543,0.2,155.35902176255118,11.0,13.0,144.96706454465075,4.9987203825026764e-23,ABC-F inter-NBD linker activation,True,assigned_and_evaluated +3017,72011,16.248608,0.9980469,"AMP-binding enzyme, C-terminal domain superfamily",interpro,45551,SKP1/BTB/POZ domain superfamily,0.84521484,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,9.0,14.0,379.48302687411604,4.348716220164993e-22,Hydrophobic helix-loop interface; glycine hinge,True,assigned_too_few_test_positives +3018,85664,22.71888,0.7915039,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.7915039,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,20.0,20.0,331.22777777777776,1.2127040143295405e-49,MurG GT-B catalytic cleft,True,assigned_too_few_test_positives +3019,87326,23.227055,0.64404297,Coiled coil,keyword,87326,Coiled coil,0.64404297,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.648241531572619,0.09697389284715426,0.03943287549844927,,2.459214338831766,10.0,15.0,8.40501867907239,4.028472162542888e-08,N-terminal helix nucleation segments,True,assigned_and_evaluated +3020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal receptor-binding modules,False,no_term_above_threshold +3021,64016,18.364874,0.8808594,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.8808594,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9313015873015873,0.026164565498525166,0.0031014621178555605,,8.436203475738758,0.0,11.0,0.0,1.0,Coil-to-beta domain-entry loop,True,assigned_and_evaluated +3022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β1–α1 cap motif,False,no_term_above_threshold +3023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Riboflavin enzyme catalytic loops,False,no_term_above_threshold +3024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CE4 deacetylase C-terminal active-site patch,False,no_term_above_threshold +3025,63831,20.325176,0.94677734,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.94677734,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9174440989189989,0.0177507052509919,0.002658396101019052,,6.677223625248119,1.0,15.0,16.35692729766804,0.09749559560090926,β→α N-cap metal-binding loops,True,assigned_and_evaluated +3026,63831,18.819513,0.9790039,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9790039,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.989041907300459,0.12566062440301792,0.002658396101019052,,47.26933821293524,1.0,16.0,15.334619341563787,0.10353836431981432,Short amphipathic contact helix,True,assigned_and_evaluated +3027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bifunctional GlnE pan-protein activation,False,no_term_above_threshold +3028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil scaffolds and cofactor loops,False,no_term_above_threshold +3029,85669,16.139254,0.70166016,3.40.50.2300,gene3d,85669,3.40.50.2300,0.70166016,62,gene3d,3.40.50.2300,gene3d:gene3d:3.40.50.2300,5.0,2257.0,0.6966696269982238,0.40132919805050954,0.002215330084182543,0.4,181.16000000000003,15.0,16.0,238.8661858974359,4.2599805974581937e-35,Ligand-binding cleft hinge loops,True,assigned_and_evaluated +3030,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MsrA/MsrB catalytic cysteine motif,False,no_term_above_threshold +3031,58239,15.904653,0.6635742,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6635742,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7162156066756878,0.04105352720104248,0.017722640673460344,,2.316445272318822,10.0,17.0,21.089101906547345,9.802692275690581e-12,Electropositive nucleic-acid interaction helix,True,assigned_and_evaluated +3032,31094,16.3999,0.9897461,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.90722656,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9954161103693814,0.33169066898014266,0.004430660168365086,,74.8625839888182,0.0,14.0,0.0,1.0,G6PD central domain GQYK hotspot,True,assigned_and_evaluated +3033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory tails and insertions,False,no_term_above_threshold +3034,50338,16.753426,0.97558594,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6044922,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Extracellular TM helix–loop junctions,True,assigned_too_few_test_positives +3035,38654,17.602228,0.99853516,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99853516,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,19.0,0.0,1.0,OB-fold ssDNA scaffolds,True,assigned_too_few_test_positives +3036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PDZ scaffolds and regulatory proteases,False,no_term_above_threshold +3037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase catalytic core motif,False,no_term_above_threshold +3038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended structured domain surfaces,False,no_term_above_threshold +3039,37894,25.30677,1.0,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9267578,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR cofactor-binding beta strand,True,assigned_too_few_test_positives +3040,64058,21.154715,0.66748047,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.66259766,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.5662696643525891,0.14817393505918097,0.006202924235711121,0.14285714285714285,23.887755102040817,11.0,14.0,89.56992624965855,1.9901647026599223e-20,Rossmann dehydrogenase C-terminal helix activation,True,assigned_and_evaluated +3041,10369,16.231636,0.6982422,DNA integration,go_bp,10369,DNA integration,0.6982422,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,11.0,12.0,501.3998470948012,1.9948701104363475e-29,Retroviral integrase DDE domain,True,assigned_too_few_test_positives +3042,36104,16.834185,0.9921875,Rho GTPase-activating protein domain,interpro,46082,PH-like domain superfamily,0.87939453,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,7.0,15.0,272.77581699346405,5.280225753399781e-16,Phospho-rich regulatory IDRs,True,assigned_too_few_test_positives +3043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SP/TP-rich low-complexity IDRs,False,no_term_above_threshold +3044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory beta-sandwich loops,False,no_term_above_threshold +3045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RUN domain hydrophobic core,False,no_term_above_threshold +3046,85682,21.159655,0.6694336,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6694336,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7055913978494623,0.15987875129712853,0.011076650420912717,0.04,14.433853667104763,7.0,15.0,47.7240708976558,1.0516567464423881e-10,E1 C-terminal CXXC zinc cluster,True,assigned_and_evaluated +3047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disorder-to-order boundary linkers,False,no_term_above_threshold +3048,88160,16.104244,0.78564453,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.78564453,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Outer-membrane beta-barrel strand-turns,True,assigned_too_few_test_positives +3049,29104,24.315535,0.84228516,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.83935547,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,11.0,11.0,428.9280575539568,2.68532943002915e-29,TM interfacial helix caps,True,assigned_too_few_test_positives +3050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,L-asparaginase N-terminal helix-loop motif,False,no_term_above_threshold +3051,88161,74.23801,0.8125,Transmembrane helix,keyword,88161,Transmembrane helix,0.8125,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8583991502450213,0.7407066115335648,0.1847585290208241,0.7937649880095923,4.009052331489822,16.0,16.0,5.4274920345926265,3.815160537588821e-12,Alpha-helical transmembrane regions,True,assigned_and_evaluated +3052,87489,16.638021,0.6557617,GPI-anchor,keyword,87489,GPI-anchor,0.6557617,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.6299047619047619,0.017355081636977573,0.0031014621178555605,,5.595774179236912,0.0,20.0,0.0,1.0,Charged coiled-coil and repeat stalks,True,assigned_and_evaluated +3053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calmodulin binding IQ helix,False,no_term_above_threshold +3054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic GP/PTS low-complexity tracts,False,no_term_above_threshold +3055,59229,32.968113,0.79833984,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.79833984,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8007376123934452,0.44840458702389907,0.0101905183872397,0.6086956521739131,44.00213708317131,12.0,13.0,98.10119292472234,1.5893007827992264e-23,Class I SAM-binding fold,True,assigned_and_evaluated +3056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann SAM and P-loop motifs,False,no_term_above_threshold +3057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Patatin-like phospholipase domain,False,no_term_above_threshold +3058,64507,30.321892,0.9975586,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9975586,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin-repeat interhelical loops,True,assigned_and_evaluated +3059,48241,22.275938,0.98339844,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.98339844,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,17.0,17.0,387.14935064935065,6.892595500529335e-44,Metal-adjacent cupin loop-helix junction,True,assigned_too_few_test_positives +3060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered tails and extended helices,False,no_term_above_threshold +3061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA-like P-loop NTPase core,False,no_term_above_threshold +3062,36776,19.165056,0.99902344,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.79345703,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,1.0,1.0,0.002658396101019052,1.0,376.16666666666663,18.0,18.0,318.8288770053476,7.346851620433348e-45,Myb/SANT DNA-binding domains,True,assigned_and_evaluated +3063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Gly-rich disordered segments,False,no_term_above_threshold +3064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-wide activation in nucleic-acid proteins,False,no_term_above_threshold +3065,72011,16.098522,0.9243164,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9243164,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,Patatin-like phospholipase A core,True,assigned_too_few_test_positives +3066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Localized binding interface motifs,False,no_term_above_threshold +3067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase catalytic headpiece,False,no_term_above_threshold +3068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-activated hydrolase and ADP-ribose cores,False,no_term_above_threshold +3069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil scaffolds,False,no_term_above_threshold +3070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal assembly scaffolding segments,False,no_term_above_threshold +3071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-strand-rich motif,False,no_term_above_threshold +3072,85649,30.787903,0.9560547,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9536133,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8649235140710754,0.6221058017724324,0.0101905183872397,0.7391304347826086,61.04751280871216,0.0,17.0,0.0,1.0,REC β1–α1 acidic pocket,True,assigned_and_evaluated +3073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PRTase C-terminal α/β core,False,no_term_above_threshold +3074,64016,27.20091,0.9746094,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.9741211,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9223809523809524,0.6102808472831892,0.0031014621178555605,0.5714285714285714,196.77198175973686,15.0,15.0,221.63940520446096,2.3373385437977913e-35,Aromatic-flanked Cys/Sec active sites,True,assigned_and_evaluated +3075,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted helices/coils; PTP glycine,False,no_term_above_threshold +3076,36776,16.107294,0.8930664,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.64501953,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.998223011994669,0.8666666666666667,0.002658396101019052,0.8333333333333334,326.0111111111111,15.0,15.0,318.8288770053476,1.0281191948075094e-37,Disordered low-complexity activation tails,True,assigned_and_evaluated +3077,81540,15.619759,1.0,"Tetracycline Repressor, domain 2",gene3d,81540,"Tetracycline Repressor, domain 2",1.0,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,20.0,20.0,828.0694444444445,2.4307463492151184e-57,Helical bundle ligand-binding pockets,True,assigned_too_few_test_positives +3078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic membrane interface domains,False,no_term_above_threshold +3079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-centered beta-strand motifs,False,no_term_above_threshold +3080,87697,17.95002,0.8618164,Knottin,keyword,87413,Disulfide bond,0.83251953,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9838327437515896,0.322000767161554,0.017279574656623838,,18.634762345734035,0.0,17.0,0.0,1.0,Secreted cysteine-rich mini-domains,True,assigned_and_evaluated +3081,49116,17.903234,0.8129883,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8129883,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8938721136767318,0.2111573517311222,0.002215330084182543,,95.31642857142857,11.0,18.0,53.189862124898625,3.074256744799429e-17,Acidic Ser/Thr-rich linker helices,True,assigned_and_evaluated +3082,50338,16.722374,0.9116211,"GPCR, rhodopsin-like, 7TM",interpro,87276,Cell membrane,0.60839844,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Interfacial TM helix boundaries,True,assigned_too_few_test_positives +3083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal juxtamembrane soluble interaction domains,False,no_term_above_threshold +3084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytochrome b-like transmembrane core,False,no_term_above_threshold +3085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extrinsic/periplasmic domain detector,False,no_term_above_threshold +3086,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cross-family DUB/UBA signature,False,no_term_above_threshold +3087,55053,21.25136,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,18.0,19.0,522.9912280701753,8.320203081731553e-48,Noncatalytic N-terminal extensions,True,assigned_too_few_test_positives +3088,64148,33.835693,0.9707031,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.92041016,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9896994496966276,0.31170884289544587,0.008418254319893664,,37.027729390264284,10.0,18.0,49.436981757877284,2.8491089759767116e-15,Basic amphipathic docking helices,True,assigned_and_evaluated +3089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Edge-strand interface module,False,no_term_above_threshold +3090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAP-associated C-terminal domain,False,no_term_above_threshold +3091,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligase and GTase NTase core,False,no_term_above_threshold +3092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad IDR/coiled-coil activation,False,no_term_above_threshold +3093,64058,31.663488,0.8432617,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.83935547,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8871409464365326,0.5762638009407773,0.006202924235711121,0.6428571428571429,92.90195705166674,15.0,15.0,113.99808795411089,4.589611073054062e-31,Rossmann NAD(P)-binding subdomain,True,assigned_and_evaluated +3094,36449,23.083223,0.92089844,EamA domain,interpro,36449,EamA domain,0.92089844,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,15.0,0.0,1.0,Polar N-terminal secretion prosegments,True,assigned_too_few_test_positives +3095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lys/Arg-rich polyanion-binding patch,False,no_term_above_threshold +3096,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NqrB FMN attachment motif,False,no_term_above_threshold +3097,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular MYG sensory loop,False,no_term_above_threshold +3098,85656,17.65324,0.64697266,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.64697266,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.7801904761904762,0.32785981029540745,0.0031014621178555605,0.2857142857142857,105.71137026239066,9.0,10.0,127.1537914691943,1.0204838786619866e-18,Hydrolase propeptides and lids,True,assigned_and_evaluated +3099,85649,40.076893,0.9892578,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9863281,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9107858783231483,0.7812073981514908,0.0101905183872397,0.782608695652174,76.66022163599628,17.0,17.0,110.61410018552876,7.110790058883305e-35,Cofactor pocket loop apex,True,assigned_and_evaluated +3100,81540,16.525377,0.9765625,"Tetracycline Repressor, domain 2",gene3d,81685,Transferase(Phosphotransferase) domain 1,0.9501953,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,0.0,15.0,0.0,1.0,Protein kinase DIYxLG signature,True,assigned_too_few_test_positives +3101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM N-terminal disordered regions,False,no_term_above_threshold +3102,59218,17.882734,0.7451172,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.7451172,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,11.0,15.0,408.617445482866,1.6556522863547524e-27,Anionic headgroup hydrolase scaffold,True,assigned_too_few_test_positives +3103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPT/LCB2 DFY motif detector,False,no_term_above_threshold +3104,88058,21.25625,0.62158203,Signal,keyword,88058,Signal,0.62158203,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6288502411800069,0.11120764046666574,0.09127159946832078,,1.2184254588993426,2.0,20.0,0.7204954682779456,1.0,Signal peptides and signal-anchor helices,True,assigned_and_evaluated +3105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic polyanion-binding patches,False,no_term_above_threshold +3106,81799,23.513031,0.9267578,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6567383,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,3.0,15.0,115.76893203883495,4.270068643553814e-06,AAA+ C-terminal helical lid,True,assigned_too_few_test_positives +3107,49236,23.212572,0.9995117,C-type lectin fold,interpro,49236,C-type lectin fold,0.9995117,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,16.0,17.0,510.12620320855615,1.225281491287518e-42,CTLD/Link hydrophobic ligand patch,True,assigned_and_evaluated +3108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary loops,False,no_term_above_threshold +3109,37640,16.303862,0.9941406,EF-hand domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.84472656,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,16.0,16.0,299.6030150753769,1.0400994007336705e-39,Ca2+-coordinating acidic residues,True,assigned_too_few_test_positives +3110,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal tails and early helices,False,no_term_above_threshold +3111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix cap/kink signal,False,no_term_above_threshold +3112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site lid/hinge regions,False,no_term_above_threshold +3113,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metallopeptidase gating scaffold,False,no_term_above_threshold +3114,46284,19.447388,0.99853516,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.99853516,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,16.0,17.0,1122.2776470588235,3.3481773613586335e-48,Active-site rim β-loops,True,assigned_too_few_test_positives +3115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycoprotein recognition domains,False,no_term_above_threshold +3116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,pfkB phosphate-binding helix,False,no_term_above_threshold +3117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cap/neck module,False,no_term_above_threshold +3118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LysM glycan-binding repeats,False,no_term_above_threshold +3119,45272,27.598225,0.9995117,"Lambda repressor-like, DNA-binding domain superfamily",interpro,37071,Homeodomain,0.9121094,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,14.0,17.0,366.4152765583845,1.3929845037599367e-34,Basic recognition-helix N-cap,True,assigned_too_few_test_positives +3120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix packing motifs,False,no_term_above_threshold +3121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory patches near active sites,False,no_term_above_threshold +3122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered low-complexity tails,False,no_term_above_threshold +3123,88058,21.71941,0.6303711,Signal,keyword,88058,Signal,0.6303711,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6246893535239737,0.1082185506281089,0.09127159946832078,,1.1856760619788436,4.0,20.0,1.4409909365558913,0.4670478563492871,Low-complexity IDRs and signal peptides,True,assigned_and_evaluated +3124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase cores and transit peptides,False,no_term_above_threshold +3125,88159,23.641632,0.6074219,Transmembrane,keyword,88159,Transmembrane,0.6074219,4311,keywords,Transmembrane,keyword:keywords:Transmembrane,421.0,2257.0,0.6552423423843013,0.3921565808414606,0.18653079308817014,0.21140142517814728,2.1023691281690655,10.0,19.0,2.779158062546322,0.0017805855157528884,"Response-regulator REC motif, TM hydrophobes",True,assigned_and_evaluated +3126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted low-complexity repeat domains,False,no_term_above_threshold +3127,83419,16.482693,0.8354492,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.82128906,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,17.0,20.0,309.01128048780487,1.3477469128397606e-40,Extracellular disordered linkers and propeptides,True,assigned_too_few_test_positives +3128,50338,20.318737,0.9663086,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8901367,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Pore-lining transmembrane helices,True,assigned_too_few_test_positives +3129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear SP/TP-rich IDRs,False,no_term_above_threshold +3130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered low complexity tails,False,no_term_above_threshold +3131,85675,19.925003,0.73828125,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.7192383,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,9.0,17.0,289.57852131678356,1.0345399949928525e-20,WBP1 lumenal beta-sandwich domain,True,assigned_too_few_test_positives +3132,49236,17.858406,0.890625,C-type lectin fold,interpro,49236,C-type lectin fold,0.890625,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.8964031971580818,0.309966875540646,0.002215330084182543,0.2,139.9190476190476,0.0,16.0,0.0,1.0,Beta-rich ligand-recognition domains,True,assigned_and_evaluated +3133,64155,17.168793,0.96191406,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9296875,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,0.0,19.0,0.0,1.0,Glycine-rich phosphate-binding loop,True,assigned_too_few_test_positives +3134,37020,19.508436,0.99609375,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,18.0,725.9786910197869,1.266441663928211e-44,Leloir glycosyltransferase catalytic motif,True,assigned_too_few_test_positives +3135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ssDNA-engaging loops and IDRs,False,no_term_above_threshold +3136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-handling and Ntn catalysis,False,no_term_above_threshold +3137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,D/E/H-rich metalloenzyme active sites,False,no_term_above_threshold +3138,36354,18.026405,0.9995117,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9995117,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,18.0,18.0,214.4640287769784,6.846421773881101e-42,RRM helical activation motif,True,assigned_too_few_test_positives +3139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-repeat adaptor/linker,False,no_term_above_threshold +3140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fold-agnostic beta-strand core residues,False,no_term_above_threshold +3141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P/ST-rich disordered regulatory hubs,False,no_term_above_threshold +3142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exported beta-barrel N-termini,False,no_term_above_threshold +3143,87882,17.409454,0.7651367,Palmitate,keyword,88058,Signal,0.69970703,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9829335110321339,0.09300785572862949,0.002658396101019052,,34.98645506325279,0.0,14.0,0.0,1.0,Extracytoplasmic peptidoglycan enzymes,True,assigned_and_evaluated +3144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helical hairpin motif,False,no_term_above_threshold +3145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic helical inserts,False,no_term_above_threshold +3146,47717,17.60816,0.9785156,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9785156,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,15.0,182.32721712538225,2.758349547914749e-21,Helicase interdomain helical brace,True,assigned_too_few_test_positives +3147,59229,24.332792,0.9501953,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9501953,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8755692655015376,0.43225483627523664,0.0101905183872397,0.6521739130434783,42.417355020574306,1.0,14.0,7.591163738222561,0.19891529922107729,CheY-fold receiver β1-α1 loop,True,assigned_and_evaluated +3148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH2 β-galactosidase β-strand motif,False,no_term_above_threshold +3149,37020,16.066778,0.95214844,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.91259766,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,7.0,20.0,285.85410958904106,5.600933453099247e-16,UDP-sugar donor-binding loop,True,assigned_too_few_test_positives +3150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short conserved loop/turn motifs,False,no_term_above_threshold +3151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured patches with regional activation,False,no_term_above_threshold +3152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal C–N hydrolase cap,False,no_term_above_threshold +3153,36272,15.6941595,0.9350586,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,64214,von Willebrand factor A-like domain superfamily,0.7763672,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,18.0,0.0,1.0,Basic amphipathic interaction surface,True,assigned_too_few_test_positives +3154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal complex assembly modules,False,no_term_above_threshold +3155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal targeting segments,False,no_term_above_threshold +3156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase-like catalytic cores,False,no_term_above_threshold +3157,64148,16.851295,0.7182617,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7182617,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.7439795870372983,0.13347104713432728,0.008418254319893664,0.05263157894736842,15.854955441167194,0.0,16.0,0.0,1.0,Histidine kinase catalytic core,True,assigned_and_evaluated +3158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal oligomerization scaffolds,False,no_term_above_threshold +3159,4066,22.268837,0.90283203,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.90283203,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7963587921847247,0.48660041774795876,0.002215330084182543,0.4,219.6514285714286,10.0,20.0,359.16265060240966,8.319634913346799e-24,Acidic phosphate-handling catalytic motifs,True,assigned_and_evaluated +3160,87586,16.694029,0.68359375,Host membrane,keyword,87760,Membrane,0.61279297,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.744198928658388,0.08021048142725344,0.01639344262295082,,4.89283936706246,0.0,14.0,0.0,1.0,Juxtamembrane low-complexity patches,True,assigned_and_evaluated +3161,64003,21.646927,0.99658203,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.79345703,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0000000000000002,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,18.0,18.0,130.4617067833698,4.066539644609368e-38,C2H2 β–α loop detector,True,assigned_and_evaluated +3162,85672,17.145561,0.6298828,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.62597656,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5728650757916853,0.0240304326016195,0.01595037660611431,,1.5065746217182006,8.0,18.0,17.784041759880687,1.0592827657735283e-08,P-loop helicase and resolvase cores,True,assigned_and_evaluated +3163,37341,17.291065,0.9326172,WD40 repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7832031,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9610031556219898,0.1295269724202819,0.011962782454585734,,10.827495435280602,0.0,19.0,0.0,1.0,Hydrophobic segments on catalytic beta-strands,True,assigned_and_evaluated +3164,45288,18.508635,0.98339844,CheY-like superfamily,interpro,85664,Glycogen Phosphorylase B;,0.92529297,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,19.0,19.0,462.17829457364337,6.130283085627497e-50,Receiver and PDE switch helix,True,assigned_too_few_test_positives +3165,86130,18.937326,0.9169922,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.91503906,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9953015873015872,0.6185062757497365,0.0031014621178555605,0.8571428571428571,199.4240949095936,16.0,16.0,240.4072580645161,3.3792037186190506e-38,Fungal Zn2C6 regulatory mid-regions,True,assigned_and_evaluated +3166,58239,15.611718,0.7133789,P-loop containing nucleoside triphosphate hydrolase,interpro,88161,Transmembrane helix,0.6323242,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7777627424447452,0.040669806203860445,0.017722640673460344,,2.294793815052826,0.0,13.0,0.0,1.0,Transmembrane helix boundary residues,True,assigned_and_evaluated +3167,85672,31.057186,0.6611328,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6567383,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6898419130521787,0.32208793636658894,0.01595037660611431,0.3611111111111111,20.19312423276087,13.0,13.0,40.01409395973155,3.774017721320684e-21,Acidic Mg2+-coordinating P-loop-adjacent motif,True,assigned_and_evaluated +3168,83419,20.68888,0.9926758,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.97998047,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,11.0,16.0,249.9355945121951,6.309538675309556e-25,Dual thrombospondin domain signature,True,assigned_too_few_test_positives +3169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase catalytic core,False,no_term_above_threshold +3170,85364,15.89116,0.7080078,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7080078,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,3.0,14.0,64.52489177489177,2.3798193343199007e-05,Venus flytrap ligand-binding ectodomains,True,assigned_too_few_test_positives +3171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil e/g faces,False,no_term_above_threshold +3172,39958,17.523455,0.9794922,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.9794922,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,1.0,1.0,0.002658396101019052,1.0,376.16666666666663,10.0,16.0,295.7390873015873,2.7882645717523685e-23,Disordered TF regulatory domains,True,assigned_and_evaluated +3173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic pocket residue,False,no_term_above_threshold +3174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helices and coiled-coils,False,no_term_above_threshold +3175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered C-terminal tail,False,no_term_above_threshold +3176,87413,37.368347,0.7753906,Disulfide bond,keyword,87413,Disulfide bond,0.7753906,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.7408527063260555,0.1428001872962334,0.0717766947275144,,1.9895063131333257,2.0,14.0,1.6896024031513022,0.5225550403595076,Functional cysteine thiol sites,True,assigned_and_evaluated +3177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-Gly hinged helical hairpins,False,no_term_above_threshold +3178,39971,24.628883,0.9814453,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9711914,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,13.0,16.0,538.245138888889,2.329769942544085e-34,MBL-fold C-terminal β-strand,True,assigned_too_few_test_positives +3179,47717,15.8911915,0.9243164,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.62109375,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,9.0,9.0,273.49082568807336,2.7334082403533283e-22,Helicase-flanking low-complexity IDRs,True,assigned_too_few_test_positives +3180,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic C-terminal interaction regions,False,no_term_above_threshold +3181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CDA-like deaminase C-terminal activation,False,no_term_above_threshold +3182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop junctions,False,no_term_above_threshold +3183,64599,16.314142,0.9248047,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.9248047,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,3.0,18.0,110.40925925925926,5.066323115515029e-06,Hydrophobic α-helical interaction surfaces,True,assigned_too_few_test_positives +3184,45804,20.102814,0.8300781,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.79785156,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,10.0,18.0,153.34619341563786,3.517325221284617e-20,C-terminal transporter TM bundle,True,assigned_too_few_test_positives +3185,36776,18.794281,0.9790039,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.90771484,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9961498593217829,0.27120929179752706,0.002658396101019052,,102.01989526450309,0.0,10.0,0.0,1.0,HTH helix-capping turn signature,True,assigned_and_evaluated +3186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity N-terminal IDRs,False,no_term_above_threshold +3187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FG/GLFG nucleoporin IDRs,False,no_term_above_threshold +3188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BRCT phosphopeptide-binding modules,False,no_term_above_threshold +3189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted O-acyl helical cap,False,no_term_above_threshold +3190,49116,23.223383,0.94433594,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.94433594,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9978685612788633,0.6000000000000001,0.002215330084182543,0.4,270.84000000000003,17.0,20.0,73.98226277372262,3.6634970709041876e-30,HEAT/ARM α-solenoid linkers,True,assigned_and_evaluated +3191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/polar helix-capping motifs,False,no_term_above_threshold +3192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hepadnaviral polymerase TP domain,False,no_term_above_threshold +3193,84152,28.26203,0.9980469,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9980469,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,Catalytic pocket-lining loops,True,assigned_too_few_test_positives +3194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity disordered regions,False,no_term_above_threshold +3195,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory beta-sandwich loop activation,False,no_term_above_threshold +3196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended hydrophobic interaction surfaces,False,no_term_above_threshold +3197,81858,17.287258,0.890625,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.68408203,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic TM helix cores,True,assigned_too_few_test_positives +3198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted lectin-like ectodomains,False,no_term_above_threshold +3199,49236,16.157892,0.9370117,C-type lectin fold,interpro,49236,C-type lectin fold,0.9370117,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,16.0,16.0,542.0090909090909,9.368724934240899e-44,C-type lectin binding loop,True,assigned_and_evaluated +3200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich beta-strand segments,False,no_term_above_threshold +3201,30398,18.46959,0.703125,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.703125,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6226827491297661,0.2399081644983284,0.004873726185201595,0.2727272727272727,49.22479338842975,9.0,9.0,72.00603864734299,4.4854289538285064e-17,ABC NBD pre-signature loop,True,assigned_and_evaluated +3202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and signal peptides,False,no_term_above_threshold +3203,36010,17.229288,0.88183594,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.8652344,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,11.0,0.0,1.0,Serine hydrolase His–Asp disordered phospho-tails,True,assigned_too_few_test_positives +3204,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inteins and terminal IDRs,False,no_term_above_threshold +3205,85656,26.77529,0.79248047,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.79248047,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8502857142857143,0.3160376471851881,0.0031014621178555605,0.2857142857142857,101.89956709956708,8.0,18.0,62.79199578725645,5.407369850910916e-13,Cell-envelope hydrolase catalytic domains,True,assigned_and_evaluated +3206,29104,17.33092,0.6645508,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.6645508,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,2.0,11.0,77.98691955526488,0.0005247312092369175,Hydrophobic multi-pass TM helices,True,assigned_too_few_test_positives +3207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal assembly tails,False,no_term_above_threshold +3208,88160,16.054392,0.87646484,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.87646484,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,18.0,257.2642934196332,2.1827294665727175e-37,Outer-membrane beta-barrel strands,True,assigned_too_few_test_positives +3209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid phosphate-binding surface,False,no_term_above_threshold +3210,61392,23.755993,0.99902344,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.6123047,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9991111111111111,0.7113945578231291,0.0031014621178555605,1.0,229.37393100097177,20.0,20.0,167.4747191011236,3.4711901829092086e-44,LRR strand-helix junction loops,True,assigned_and_evaluated +3211,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed coiled-coil scaffold helices,False,no_term_above_threshold +3212,49116,23.682535,0.97265625,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97265625,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.999644760213144,0.81,0.002215330084182543,1.0,365.63400000000007,19.0,20.0,82.68605839416058,1.163776261464173e-35,HEAT/ARM helical repeat cores,True,assigned_and_evaluated +3213,36951,16.384872,0.66064453,SET domain,interpro,36951,SET domain,0.66064453,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,14.0,0.0,1.0,Post-signal-peptide mature regions,True,assigned_too_few_test_positives +3214,42974,18.429077,0.93896484,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.86621094,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9993650793650792,0.8255625327053897,0.0031014621178555605,1.0,266.18494804515205,3.0,14.0,28.51769770408163,0.00026191279299118936,Broad GPCR EC2/TM4 and WYL-loop,True,assigned_and_evaluated +3215,87970,16.56738,0.64501953,Protein phosphatase,keyword,87970,Protein phosphatase,0.64501953,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,13.0,0.0,1.0,Cyclase-adjacent noncatalytic regions,True,assigned_too_few_test_positives +3216,85649,17.882124,0.84814453,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.84277344,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9350356155852244,0.09961396099977375,0.0101905183872397,,9.775161303325623,0.0,15.0,0.0,1.0,REC and nucleotide-handling enzymes,True,assigned_and_evaluated +3217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NF-κB RHD and low-complexity IDRs,False,no_term_above_threshold +3218,48883,25.362106,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,13.0,13.0,480.8145161290322,3.7255170365673266e-35,Fold type I PLP enzymes,True,assigned_too_few_test_positives +3219,36535,19.923437,0.9194336,Protein kinase domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7553711,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9376724521584334,0.15616844643982516,0.004430660168365086,,35.24721836146854,0.0,15.0,0.0,1.0,Histidine kinase HATPase_c domain,True,assigned_and_evaluated +3220,36104,16.93983,0.95996094,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.95996094,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Plant phospho-prone low-complexity IDRs,True,assigned_too_few_test_positives +3221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal basic interaction tails,False,no_term_above_threshold +3222,37690,20.574224,0.8310547,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.8310547,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.8366349206349206,0.1111768015803204,0.0031014621178555605,0.14285714285714285,35.84657730954045,1.0,19.0,9.508931419457735,0.16202083774466558,Broad activation T3SS/T4SS effectors,True,assigned_and_evaluated +3223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exporter periplasmic lobe motif,False,no_term_above_threshold +3224,85364,23.429842,0.7832031,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7832031,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,17.0,301.1161616161616,4.0879330105973736e-42,Periplasmic oxyanion-binding SBPs,True,assigned_too_few_test_positives +3225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic signaling coiled-coils,False,no_term_above_threshold +3226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid-binding SNase/OB/Tudor barrels,False,no_term_above_threshold +3227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asparagine loop/disorder signal,False,no_term_above_threshold +3228,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylation-prone ectodomain loops,False,no_term_above_threshold +3229,36354,25.751375,0.98876953,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.98095703,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,13.0,0.0,1.0,S1/OB-fold ssRNA-binding interface,True,assigned_too_few_test_positives +3230,59237,15.894936,0.99658203,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.99658203,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,9.0,16.0,176.5095394736842,7.903460831547331e-19,Short amphipathic helical interfaces,True,assigned_too_few_test_positives +3231,87276,28.732042,0.6020508,Cell membrane,keyword,87276,Cell membrane,0.6020508,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.5881459208033271,0.21361840752485475,0.11120957022596367,0.20318725099601595,1.9208635290183154,4.0,18.0,1.8234394592776095,0.2670540040780674,Helix-helix interface segments,True,assigned_and_evaluated +3232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse domain-spanning activation,False,no_term_above_threshold +3233,87105,18.004807,0.7192383,4Fe-4S,keyword,87105,4Fe-4S,0.7192383,93,keywords,4Fe-4S,keyword:keywords:4Fe-4S,,,,,,,,12.0,14.0,127.44068400427503,1.937205221178109e-24,Respiratory Fe-S ferredoxin subunits,True,assigned_too_few_test_positives +3234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Sec/Tat signal helices,False,no_term_above_threshold +3235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class II aaRS-like domains,False,no_term_above_threshold +3236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDR linkers,False,no_term_above_threshold +3237,31094,17.41983,0.9785156,phosphopantetheine binding,go_mf,85682,NAD(P)-binding Rossmann-like Domain,0.7558594,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9485536270582999,0.5705468511206216,0.004430660168365086,0.9,128.77242429792432,0.0,16.0,0.0,1.0,SDR YxxxK catalytic patch,True,assigned_and_evaluated +3238,52236,24.87057,0.91796875,Tetratricopeptide repeat,interpro,52236,Tetratricopeptide repeat,0.91796875,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,12.0,18.0,148.8664169787765,2.7173132368291117e-24,Acidic TPR-flanking IDRs,True,assigned_too_few_test_positives +3239,81858,16.034355,0.93603516,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6557617,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Re-entrant pore-lining GSNIGT motif,True,assigned_too_few_test_positives +3240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short low-complexity peptides/proteins,False,no_term_above_threshold +3241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic accessory regions,False,no_term_above_threshold +3242,87873,15.918558,0.6303711,Oxidoreductase,keyword,87873,Oxidoreductase,0.6303711,537,keywords,Oxidoreductase,keyword:keywords:Oxidoreductase,48.0,2257.0,0.6993266183793572,0.1629762228919931,0.021267168808152416,0.125,7.663277813900591,7.0,17.0,10.354206465378223,4.0609902702116424e-06,Core β-strands preceding active-site loops,True,assigned_and_evaluated +3243,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity N-terminal regulatory tail,False,no_term_above_threshold +3244,58239,33.3824,0.6791992,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6791992,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6337731168245376,0.16806286849091243,0.017722640673460344,0.275,9.482947354599734,16.0,16.0,35.851473241130485,3.796994109691943e-25,NTPase interdomain lid hinge,True,assigned_and_evaluated +3245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic alpha-helical interfaces,False,no_term_above_threshold +3246,63831,16.567986,0.6166992,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.6166992,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5801865837405599,0.1688819967508492,0.002658396101019052,0.16666666666666666,63.52777777777777,0.0,12.0,0.0,1.0,Asx-rich loop/turn motifs,True,assigned_and_evaluated +3247,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compositionally biased low-complexity IDRs,False,no_term_above_threshold +3248,36091,18.939516,1.0,GNAT domain,interpro,85712,3.40.630.30,0.9980469,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,Conserved GNAT CoA-binding β-strands,True,assigned_too_few_test_positives +3249,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site adjacent loops,False,no_term_above_threshold +3250,39971,15.726768,0.96972656,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.79345703,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,17.0,0.0,1.0,GTPase G4/G5 guanine-recognition loop,True,assigned_too_few_test_positives +3251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ER Golgi multipass transmembrane activation,False,no_term_above_threshold +3252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity tails; catalytic residues,False,no_term_above_threshold +3253,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-CXXCH heme-positioning loops,False,no_term_above_threshold +3254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured N-terminal ectodomain activation,False,no_term_above_threshold +3255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil segments,False,no_term_above_threshold +3256,37468,16.175022,0.81103516,"Zinc finger, RING-type",interpro,37468,"Zinc finger, RING-type",0.81103516,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,17.0,0.0,1.0,Metal-hydrolase HExxH/HD spacer,True,assigned_too_few_test_positives +3257,36272,18.915041,0.9580078,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9580078,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,16.0,0.0,1.0,Disordered polar/proline-rich segments,True,assigned_too_few_test_positives +3258,45804,26.980227,0.9902344,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.95996094,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,19.0,19.0,276.02314814814815,4.995370312283082e-46,MFS A-motif cytosolic loop,True,assigned_too_few_test_positives +3259,88160,17.214512,0.7944336,Transmembrane beta strand,keyword,25167,cell outer membrane,0.65185547,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,17.0,18.0,273.3433117583603,1.238197210134836e-40,Outer-membrane β-barrel porins,True,assigned_too_few_test_positives +3260,36951,17.547062,0.8334961,SET domain,interpro,36951,SET domain,0.8334961,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,10.0,0.0,1.0,Long terminal accessory segments,True,assigned_too_few_test_positives +3261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase C-terminal extension,False,no_term_above_threshold +3262,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular loop-to-TM helix junction,False,no_term_above_threshold +3263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass transmembrane helix architecture,False,no_term_above_threshold +3264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme catalytic ectodomains,False,no_term_above_threshold +3265,36886,21.066406,0.9116211,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9116211,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.7979101823032458,0.06984771656902804,0.003544528134692069,,19.705787037037034,0.0,19.0,0.0,1.0,Coiled-coil dimerization segments,True,assigned_and_evaluated +3266,36668,20.938248,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,18.0,18.0,532.3303571428571,1.2239400872533205e-48,ANL A-domain AMP-binding core,True,assigned_too_few_test_positives +3267,50806,19.514565,0.9946289,"Homeobox, conserved site",interpro,87384,DNA-binding,0.7036133,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,12.0,0.0,1.0,HTH DNA-binding loop,True,assigned_too_few_test_positives +3268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N/Q/S/T-rich low-complexity IDRs,False,no_term_above_threshold +3269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cache-like sensory beta-strands,False,no_term_above_threshold +3270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavodoxin-like ligand-binding loop,False,no_term_above_threshold +3271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-envelope/ECM effectors and trafficking segments,False,no_term_above_threshold +3272,81858,19.41482,0.89990234,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6459961,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,2.0,17.0,30.764189886480906,0.003317090402528919,N-terminal signal-anchor helix,True,assigned_too_few_test_positives +3273,45551,16.867794,0.7446289,SKP1/BTB/POZ domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63671875,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,20.0,0.0,1.0,Amphipathic interfacial helices,True,assigned_too_few_test_positives +3274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-strand motif,False,no_term_above_threshold +3275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic redox maturation machinery,False,no_term_above_threshold +3276,82029,28.583454,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,20.0,169.27097791798107,9.692152584541787e-39,Secondary transporter TM helix caps,True,assigned_too_few_test_positives +3277,37341,30.926722,0.99853516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.95703125,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,13.0,14.0,135.0301393728223,2.9120032462342102e-27,WD40 propeller C-terminal bias,True,assigned_and_evaluated +3278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PRQH-rich disordered tails,False,no_term_above_threshold +3279,37341,18.778776,0.72216797,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.68310547,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.8629629629629629,0.27564978127133677,0.011962782454585734,,23.042279864052112,0.0,17.0,0.0,1.0,Beta-propeller glycan-binding surfaces,True,assigned_and_evaluated +3280,58239,25.808523,0.63671875,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63671875,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6837674785746504,0.2873435038904516,0.017722640673460344,0.35,16.21335720701873,17.0,18.0,33.859724727734346,1.8661278740728935e-25,P-loop NTPase coupling switch,True,assigned_and_evaluated +3281,58239,15.865923,0.72265625,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.72265625,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7171346414073072,0.03362618723113009,0.017722640673460344,,1.8973576145165154,1.0,18.0,1.991748513396138,0.6219382542938762,Fe(II)/2OG dioxygenase cupin-flanking motif,True,assigned_and_evaluated +3282,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended charged low-complexity linkers,False,no_term_above_threshold +3283,25169,17.530352,0.8642578,pilus,go_cc,47529,Immunoglobulin-like fold,0.82910156,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9985790408525755,0.4553968253968254,0.002215330084182543,1.0,205.566126984127,0.0,20.0,0.0,1.0,Surface loop hotspots,True,assigned_and_evaluated +3284,36914,18.929258,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9404297,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,16.0,736.0617283950618,7.329763891109132e-46,Acidic helix N-cap in sugar-transferases,True,assigned_too_few_test_positives +3285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low complexity disordered tails,False,no_term_above_threshold +3286,55053,16.296116,0.8203125,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.8203125,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,13.0,0.0,1.0,Phosphate-binding catalytic signature,True,assigned_too_few_test_positives +3287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping loops,False,no_term_above_threshold +3288,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity IDRs and signal peptides,False,no_term_above_threshold +3289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme catalytic core scaffold,False,no_term_above_threshold +3290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-loop lids,False,no_term_above_threshold +3291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme active-site acid/base region,False,no_term_above_threshold +3292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-lactamase/PBP helix–loop motif,False,no_term_above_threshold +3293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic C-terminal CAZyme regions,False,no_term_above_threshold +3294,64381,25.298555,0.93652344,Helix-loop-helix DNA-binding domain superfamily,interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.93652344,41,ip,IPR036638,interpro:ip:IPR036638,,,,,,,,0.0,15.0,0.0,1.0,HAMP signaling coiled-coils,True,assigned_too_few_test_positives +3295,64620,16.53515,0.99609375,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.99609375,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,16.0,16.0,324.0271739130435,3.056549823728774e-40,Histidine kinase ATP-binding motif,True,assigned_too_few_test_positives +3296,64058,21.67533,0.93603516,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.92822266,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9862906821221579,0.2235308718815523,0.006202924235711121,,36.03636984547597,17.0,18.0,107.66486084554917,7.098651611345337e-34,Cofactor-adjacent beta-strand starts,True,assigned_and_evaluated +3297,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribose processing active sites,False,no_term_above_threshold +3298,48767,20.571455,0.99365234,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99365234,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,14.0,0.0,1.0,Chromatin reader N-terminal motifs,True,assigned_too_few_test_positives +3299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/pre-domain regions,False,no_term_above_threshold +3300,82107,18.383236,0.66064453,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.6430664,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,4.0,18.0,72.39951426836673,4.952204121900076e-07,Functional-site scaffold segments,True,assigned_too_few_test_positives +3301,36876,18.20864,0.9975586,Cytochrome P450,interpro,30838,heme binding,0.74658203,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,18.0,368.03086419753083,8.574008912125439e-43,P450 active-site helical core,True,assigned_and_evaluated +3302,36535,17.295538,0.9121094,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.89941406,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9286826880284823,0.12572820600333662,0.004430660168365086,,28.376856094953077,0.0,16.0,0.0,1.0,Zinc metalloprotease catalytic helix,True,assigned_and_evaluated +3303,82716,17.284449,0.9682617,Laminin,gene3d,87413,Disulfide bond,0.6972656,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,3.0,17.0,51.07452884066248,4.935853125375923e-05,Extracellular cysteine-rich repeats,True,assigned_too_few_test_positives +3304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Thr-rich extracytoplasmic disordered linker,False,no_term_above_threshold +3305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal capping helix,False,no_term_above_threshold +3306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core beta-hairpin and loop-to-beta motifs,False,no_term_above_threshold +3307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Gly-rich disordered tails,False,no_term_above_threshold +3308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix entry caps,False,no_term_above_threshold +3309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAD Ca2+-binding catalytic core,False,no_term_above_threshold +3310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alanine racemase catalytic tyrosine,False,no_term_above_threshold +3311,81858,15.798502,0.9213867,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7290039,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,Multipass alpha-helical transmembrane segments,True,assigned_too_few_test_positives +3312,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic zinc metalloprotease periphery,False,no_term_above_threshold +3313,45317,19.628376,0.99853516,"Six-bladed beta-propeller, TolB-like",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8486328,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,13.0,13.0,764.3717948717948,7.661200220716665e-38,Catalytic beta-propeller blade motifs,True,assigned_too_few_test_positives +3314,69819,25.383738,0.8383789,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.83447266,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,13.0,14.0,389.875754527163,2.9085420366791067e-33,Kae1/TsaD carbamoyltransferases,True,assigned_too_few_test_positives +3315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible phosphate-binding loop lids,False,no_term_above_threshold +3316,87586,15.80496,0.74072266,Host membrane,keyword,88161,Transmembrane helix,0.734375,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.8006513270026783,0.10330115249250707,0.01639344262295082,,6.301370302042931,0.0,16.0,0.0,1.0,K-rich IDR G/P/S/T peaks,True,assigned_and_evaluated +3317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho‑rich disordered regulatory regions,False,no_term_above_threshold +3318,36104,26.23378,0.99658203,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99658203,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Cofactor adjacent catalytic scaffolds,True,assigned_too_few_test_positives +3319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IMPase-fold hydrophobic beta-strand,False,no_term_above_threshold +3320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic recognition helices,False,no_term_above_threshold +3321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase RNA-binding surfaces,False,no_term_above_threshold +3322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C transmembrane catalytic core,False,no_term_above_threshold +3323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved GatB C-terminal motif,False,no_term_above_threshold +3324,46932,24.63712,0.96972656,Zinc finger C2H2-type,interpro,88263,Zinc-finger,0.86376953,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9979528259902092,0.8331439393939394,0.004430660168365086,0.9,188.04058712121213,17.0,20.0,91.97431941923774,9.512079296320015e-32,Disordered flanks of Zn-binding modules,True,assigned_and_evaluated +3325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic core residues,False,no_term_above_threshold +3326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal charged interaction modules,False,no_term_above_threshold +3327,48880,15.791412,0.9243164,"Pyridoxal phosphate-dependent transferase, major domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8730469,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,0.0,16.0,0.0,1.0,Glycine-rich phosphate-binding loop,True,assigned_too_few_test_positives +3328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass hydrophobic transmembrane helices,False,no_term_above_threshold +3329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,First extracellular module,False,no_term_above_threshold +3330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved SAM-binding loop motifs,False,no_term_above_threshold +3331,38317,25.285053,1.0,Pentatricopeptide repeat,interpro,87108,ANK repeat,0.96484375,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,20.0,20.0,384.6516129032258,7.999014609586429e-51,Glycine-biased helix-capping linkers,True,assigned_and_evaluated +3332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature N-terminal assembly initiator,False,no_term_above_threshold +3333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP/Mg2+ ligation-transfer cores,False,no_term_above_threshold +3334,52941,22.413727,0.9995117,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9902344,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,19.0,19.0,260.353711790393,1.5255431321768337e-45,12-TM secondary carrier helices,True,assigned_too_few_test_positives +3335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mo/W-bisMGD YPxxR motif,False,no_term_above_threshold +3336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal macromolecule-binding modules,False,no_term_above_threshold +3337,63951,16.077772,0.7841797,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.7714844,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8199139976275207,0.09756728933221995,0.003987594151528578,,24.467708002535602,0.0,15.0,0.0,1.0,Beta-strand–rich structural domains,True,assigned_and_evaluated +3338,36272,16.197834,0.921875,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,27918,DNA-binding transcription factor activity,0.6459961,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,20.0,0.0,1.0,HTH-adjacent amphipathic hinge helix,True,assigned_too_few_test_positives +3339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter TM helices and loops,False,no_term_above_threshold +3340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT–RNase H connection module,False,no_term_above_threshold +3341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glucosamine N-deacetylase catalytic core,False,no_term_above_threshold +3342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +3343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interaction-domain beta-sheet cores,False,no_term_above_threshold +3344,82107,17.720583,0.6430664,1.20.1280.50,gene3d,82107,1.20.1280.50,0.6430664,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,11.0,0.0,1.0,Sigma factor N-terminal module,True,assigned_too_few_test_positives +3345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic lid helix,False,no_term_above_threshold +3346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signaling coiled-coil domains,False,no_term_above_threshold +3347,36409,20.650385,0.98779297,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.98779297,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,17.0,0.0,1.0,Extracellular β-strand carbohydrate-binding,True,assigned_too_few_test_positives +3348,43626,15.992142,0.9692383,Putative DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.86572266,26,ip,IPR009061,interpro:ip:IPR009061,5.0,2257.0,0.9765541740674956,0.05525782541460033,0.002215330084182543,,24.94338239215059,0.0,16.0,0.0,1.0,Winged-helix helical interface hotspots,True,assigned_and_evaluated +3349,38317,23.469578,0.9580078,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9580078,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.816063492063492,0.021262007085302386,0.0031014621178555605,,6.855478570218212,0.0,17.0,0.0,1.0,Histidine kinase catalytic domain,True,assigned_and_evaluated +3350,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Acidic catalytic residues, LRR repeats",False,no_term_above_threshold +3351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic beta-edge interaction patch,False,no_term_above_threshold +3352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rhomboid protease transmembrane core,False,no_term_above_threshold +3353,37097,28.056078,0.9663086,Cro/C1-type helix-turn-helix domain,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9301758,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,12.0,16.0,421.84669811320754,3.62405245586592e-30,HTH recognition helix signature,True,assigned_too_few_test_positives +3354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic assembly scaffolds,False,no_term_above_threshold +3355,84152,16.084108,0.93603516,Metal-dependent hydrolases,gene3d,47531,Aldolase-type TIM barrel,0.8823242,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,12.0,0.0,1.0,Aromatic-capped GG helix cap,True,assigned_too_few_test_positives +3356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RGS family membership marker,False,no_term_above_threshold +3357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface acidic-aromatic patch,False,no_term_above_threshold +3358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PH-anchored small GTPase interfaces,False,no_term_above_threshold +3359,48241,15.769985,0.98291016,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.98291016,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,18.0,19.0,366.7730690362269,3.831366179140002e-45,Cupin histidine metal-binding motif,True,assigned_too_few_test_positives +3360,64003,21.724783,0.9970703,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.8520508,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,16.0,16.0,130.4617067833698,5.252801912935239e-34,C2H2 Cys2 knuckle motif,True,assigned_and_evaluated +3361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEP-binding domain motif,False,no_term_above_threshold +3362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic His-rich cofactor interfaces,False,no_term_above_threshold +3363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,START/Bet v1 lipid-binding domains,False,no_term_above_threshold +3364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane HAMP-like coiled-coil linkers,False,no_term_above_threshold +3365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active-site lid/loop,False,no_term_above_threshold +3366,25169,22.335388,0.89697266,pilus,go_cc,25169,pilus,0.89697266,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8977353463587922,0.8004430660168365,0.002215330084182543,0.8,361.32,19.0,19.0,552.0462962962963,3.5000972430365514e-51,Gram-negative adhesin passengers,True,assigned_and_evaluated +3367,37576,17.182287,0.98046875,"Zinc finger, PHD-type",interpro,63831,F-box-like domain superfamily,0.9213867,31,ip,IPR001965,interpro:ip:IPR001965,,,,,,,,0.0,16.0,0.0,1.0,PAS sensor relay residues,True,assigned_too_few_test_positives +3368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged transcription DNA-binding regions,False,no_term_above_threshold +3369,63831,20.070625,0.92089844,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.92089844,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8602102769139641,0.010734244010477886,0.002658396101019052,,4.037864788608098,0.0,6.0,0.0,1.0,Active-site helical scaffolds,True,assigned_and_evaluated +3370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic disordered anion-binding segments,False,no_term_above_threshold +3371,64168,21.642982,0.7207031,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.7207031,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.8979573712255773,0.6231703387441092,0.002215330084182543,0.6,281.2990909090909,10.0,11.0,304.49948927477016,1.4244908719306044e-24,P-type ATPase TGD loop,True,assigned_and_evaluated +3372,87326,22.865093,0.61279297,Coiled coil,keyword,87326,Coiled coil,0.61279297,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6336213151457357,0.2420130079072833,0.03943287549844927,0.23595505617977527,6.137341110637511,16.0,18.0,11.20669157209652,7.469626005007722e-16,Charged coiled-coil adaptor scaffolds,True,assigned_and_evaluated +3373,36104,28.924593,0.96484375,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.96484375,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,C-terminal K/R-PGITG[WL] motif,True,assigned_too_few_test_positives +3374,85664,16.661755,0.9741211,Glycogen Phosphorylase B;,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.85498047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Lipid-linked glycosyltransferases,True,assigned_too_few_test_positives +3375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide phosphate-binding loop,False,no_term_above_threshold +3376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nitrilase-fold cysteine amidases,False,no_term_above_threshold +3377,45324,20.242111,0.8598633,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.8598633,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.4955595026642984,0.002215330084182543,0.002215330084182543,,1.0,12.0,15.0,437.58532110091744,1.314377206300329e-30,Extracellular polysaccharide-degrading CAZymes,True,assigned_and_evaluated +3378,35372,16.847097,0.79248047,ABC-type transporter activity,go_mf,87484,G-protein coupled receptor,0.7114258,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,17.0,0.0,1.0,Small-residue TM packing helices,True,assigned_too_few_test_positives +3379,37341,23.891996,0.98583984,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98339844,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9991612688922106,0.8603240750500635,0.011962782454585734,1.0,71.91671990325901,9.0,17.0,76.98550932568149,1.7209573680457718e-15,N2OR CuZ helical motif,True,assigned_and_evaluated +3380,42054,16.376322,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,16.0,16.0,677.5113636363636,2.854844545958869e-45,Radical SAM C-terminal accessories,True,assigned_too_few_test_positives +3381,88161,20.933933,0.6118164,Transmembrane helix,keyword,88161,Transmembrane helix,0.6118164,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5166086695860702,0.18515499620613274,0.1847585290208241,,1.002145866755975,3.0,18.0,0.9045820057654377,1.0,Secretory and membrane-interface signal,True,assigned_and_evaluated +3382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic helical scaffolds,False,no_term_above_threshold +3383,36535,17.955027,0.7919922,Protein kinase domain,interpro,36535,Protein kinase domain,0.7919922,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.946328437917223,0.537862628436399,0.004430660168365086,0.7,121.39559523809525,0.0,19.0,0.0,1.0,N-terminal basic helices; aromatic peaks,True,assigned_and_evaluated +3384,45714,15.730509,0.9970703,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,88150,Transcription regulation,0.60498047,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,14.0,14.0,298.105,7.283149953202633e-35,Transactivation IDRs flanking DBDs,True,assigned_too_few_test_positives +3385,48880,16.055593,0.8203125,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.8203125,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,PLP-dependent aminotransferase-like fold,True,assigned_too_few_test_positives +3386,85649,34.109535,0.9824219,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9794922,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8864874858900004,0.7289456950526216,0.0101905183872397,0.782608695652174,71.53175798842464,16.0,16.0,110.61410018552876,7.117153535323136e-33,AdoMet pocket PGG loop,True,assigned_and_evaluated +3387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disorder-to-helix boundary motif,False,no_term_above_threshold +3388,88009,17.128975,0.6035156,Repeat,keyword,88009,Repeat,0.6035156,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6790462983464044,0.15379526427897977,0.07266282676118742,,2.116560435839374,12.0,17.0,6.25805379400831,3.010409173114462e-08,His/Gly metal-binding motifs,True,assigned_and_evaluated +3389,45324,19.095123,0.9975586,Pectin lyase fold/virulence factor,interpro,36409,"Zinc finger, CCCH-type",0.87597656,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9990230905861457,0.5449999999999999,0.002215330084182543,1.0,246.01299999999998,15.0,15.0,546.9816513761467,3.1549135532889026e-41,Acidic glycine-rich beta-helix loops,True,assigned_and_evaluated +3390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trp-rich polymer-binding modules,False,no_term_above_threshold +3391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil interfaces,False,no_term_above_threshold +3392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface alpha helices,False,no_term_above_threshold +3393,27936,17.186943,0.7529297,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.7529297,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,8.0,8.0,641.0860215053764,7.251916484533769e-23,Cyclophilin-like PPIase detector,True,assigned_too_few_test_positives +3394,37071,17.084436,0.94189453,Homeodomain,interpro,80926,Homeodomain-like,0.83447266,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,16.0,0.0,1.0,Hydrophobic helical segments,True,assigned_too_few_test_positives +3395,52941,23.199429,0.9272461,Major facilitator superfamily domain,interpro,82029,MFS general substrate transporter like domains,0.85009766,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,11.0,0.0,1.0,Transmembrane helix–loop–helix hairpins,True,assigned_too_few_test_positives +3396,52236,20.253597,0.9926758,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98535156,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,17.0,210.16435338180213,1.624802082425761e-36,TPR repeat boundary residues,True,assigned_too_few_test_positives +3397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich beta-hairpin cap,False,no_term_above_threshold +3398,88058,17.685349,0.6074219,Signal,keyword,88058,Signal,0.6074219,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.619442090763208,0.10771010621096827,0.09127159946832078,,1.180105386981337,3.0,20.0,1.0807432024169183,0.8334769282943363,Ser/Pro-rich disordered tails,True,assigned_and_evaluated +3399,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail activation,False,no_term_above_threshold +3400,82029,26.588898,0.9980469,MFS general substrate transporter like domains,gene3d,87276,Cell membrane,0.62158203,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,20.0,150.46309148264984,5.968125115789744e-33,TM helix packing residues,True,assigned_too_few_test_positives +3401,37446,20.495674,0.96728516,F-box domain,interpro,37446,F-box domain,0.96728516,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9562222222222222,0.03793694734422092,0.0031014621178555605,,12.231955736558088,0.0,17.0,0.0,1.0,Histidine kinase catalytic core,True,assigned_and_evaluated +3402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity interface patches,False,no_term_above_threshold +3403,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disorder-to-order initiation motif,False,no_term_above_threshold +3404,85712,16.675064,0.9848633,3.40.630.30,gene3d,85712,3.40.630.30,0.9848633,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,15.0,15.0,283.9095238095238,5.866714134664817e-37,GNAT acetyl-CoA P-loop,True,assigned_too_few_test_positives +3405,82029,18.416977,0.9580078,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8520508,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,20.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +3406,50869,21.44571,0.96972656,"DNA binding HTH domain, AraC-type",interpro,46079,Tetratricopeptide-like helical domain superfamily,0.81103516,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,20.0,0.0,1.0,C-terminal scaffold/regulatory tails,True,assigned_too_few_test_positives +3407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M20/M28 dimetal active-site motif,False,no_term_above_threshold +3408,64058,20.01243,0.8901367,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7939453,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9615948028787976,0.08241462862816303,0.006202924235711121,,13.286415486697425,7.0,15.0,53.199107711918415,4.968654152534858e-11,Alpha-helical cofactor scaffolds,True,assigned_and_evaluated +3409,46284,25.597073,0.99658203,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.99658203,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,17.0,0.0,1.0,NTase nucleotidylation loop,True,assigned_too_few_test_positives +3410,30398,19.094854,0.64453125,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.64453125,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.5883591030518903,0.1858057759697104,0.004873726185201595,0.18181818181818182,38.12396694214876,13.0,13.0,72.00603864734299,1.9317143050495217e-24,ABC NBD dimerization helix,True,assigned_and_evaluated +3411,38654,20.118921,0.98095703,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.96777344,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,18.0,0.0,1.0,OB/S1 ssNA-binding boundary segments,True,assigned_too_few_test_positives +3412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix capping motifs,False,no_term_above_threshold +3413,64148,29.737589,0.7939453,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7939453,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8602370537604064,0.30095234845495367,0.008418254319893664,0.10526315789473684,35.74997107699108,19.0,19.0,88.9865671641791,4.383349844353145e-37,Pre-HTH DNA-anchoring arm,True,assigned_and_evaluated +3414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged hinge/linker loops,False,no_term_above_threshold +3415,87326,19.001522,0.6435547,Coiled coil,keyword,87326,Coiled coil,0.6435547,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6030437621791949,0.060150258760074335,0.03943287549844927,,1.5253835283313233,5.0,19.0,3.3177705312127856,0.024051590211561284,Basic mixed-charge helical linkers,True,assigned_and_evaluated +3416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Linkers and ligand-binding motifs,False,no_term_above_threshold +3417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix/coiled-coil terminus signature,False,no_term_above_threshold +3418,87149,24.725954,0.7661133,Amphibian defense peptide,keyword,88161,Transmembrane helix,0.69873047,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7926680766519261,0.07701165622757913,0.012405848471422242,,6.2076895752016465,0.0,17.0,0.0,1.0,Signal-anchor and amphipathic helices,True,assigned_and_evaluated +3419,59224,34.119072,0.9008789,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9008789,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9258095238095239,0.6635604868982325,0.0031014621178555605,0.7142857142857143,213.9508598470444,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Hydrolase C-terminal catalytic His,True,assigned_and_evaluated +3420,85649,22.473724,0.95751953,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9555664,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.933945739753221,0.6434147384273344,0.0101905183872397,0.6521739130434783,63.13856802741277,14.0,14.0,110.61410018552876,7.27210921345717e-29,SAM MTase alpha-beta anchor,True,assigned_and_evaluated +3421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Uniform activation across short proteins,False,no_term_above_threshold +3422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Secondary-structure scaffolds, processing junctions",False,no_term_above_threshold +3423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble membrane zinc metalloprotease regions,False,no_term_above_threshold +3424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop hairpins,False,no_term_above_threshold +3425,36010,15.935717,0.87158203,Alpha/beta hydrolase fold-1,interpro,85388,Glutaredoxin,0.8022461,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,13.0,0.0,1.0,N-terminal domain-start segment,True,assigned_too_few_test_positives +3426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic microenvironment scaffolds,False,no_term_above_threshold +3427,37640,22.6643,0.99658203,EF-hand domain,interpro,46081,EF-hand domain pair,0.9916992,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,16.0,16.0,299.6030150753769,1.0400994007336705e-39,Calcium-responsive N-terminal IDRs,True,assigned_too_few_test_positives +3428,36354,21.626215,0.9667969,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9638672,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,12.0,0.0,1.0,Domain-edge flexible linkers,True,assigned_too_few_test_positives +3429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bilayer-penetrating fusion/pore modules,False,no_term_above_threshold +3430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered regulatory tails,False,no_term_above_threshold +3431,48883,16.18489,0.90234375,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.90234375,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,0.0,14.0,0.0,1.0,Active-site loop-to-strand entries,True,assigned_too_few_test_positives +3432,87326,16.388378,0.6152344,Coiled coil,keyword,87326,Coiled coil,0.6152344,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6980181599568803,0.1470342303821827,0.03943287549844927,,3.7287219996919814,7.0,17.0,5.1913350664858875,0.0003387372001237289,Charged helix-cap loops,True,assigned_and_evaluated +3433,48255,16.055683,0.8618164,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.8618164,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,11.0,16.0,234.22535714285715,1.3023373443007147e-24,Pocket-flanking beta strand,True,assigned_too_few_test_positives +3434,43583,17.015697,0.9375,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9375,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,10.0,10.0,416.9300699300699,1.4595016026239996e-26,Trypsin-fold active-site loops,True,assigned_and_evaluated +3435,63831,15.608902,0.671875,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.671875,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5567155338368133,0.0038334530615288217,0.002658396101019052,,1.442017259978425,0.0,19.0,0.0,1.0,Charged surface capping loop,True,assigned_and_evaluated +3436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal mixed-charge tails,False,no_term_above_threshold +3437,50869,17.527042,0.9951172,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.9951172,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,20.0,0.0,1.0,PAS glycine helix C-cap,True,assigned_too_few_test_positives +3438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-cap boundary signal,False,no_term_above_threshold +3439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding catalytic loops,False,no_term_above_threshold +3440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GIY-YIG motif recognizer,False,no_term_above_threshold +3441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-buttressing beta strands,False,no_term_above_threshold +3442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Ser-rich catalytic beta-alpha loops,False,no_term_above_threshold +3443,4066,23.005072,0.9633789,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9633789,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.8917850799289521,0.6137763993501698,0.002215330084182543,0.6,277.0586666666667,16.0,20.0,574.6602409638555,2.4347063412153246e-42,Noncatalytic nuclease helix-coil regions,True,assigned_and_evaluated +3444,50806,15.727023,0.8442383,"Homeobox, conserved site",interpro,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.6611328,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,15.0,0.0,1.0,Disordered phosphorylation-rich regulatory regions,True,assigned_too_few_test_positives +3445,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Riboflavin reductase C-terminal motif,False,no_term_above_threshold +3446,85675,19.463568,0.91845703,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9003906,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,14.0,16.0,478.60894495412845,1.374908525618535e-36,Low-complexity linker activation,True,assigned_too_few_test_positives +3447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Minor pseudopilin C-terminal tip,False,no_term_above_threshold +3448,50338,15.574829,0.80810547,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.80810547,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane helix exit motif,True,assigned_too_few_test_positives +3449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,APTPT-like acidic loop motif,False,no_term_above_threshold +3450,61392,21.869877,0.9453125,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.9453125,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.8308571428571428,0.043273281508340436,0.0031014621178555605,,13.952542337760622,0.0,15.0,0.0,1.0,β-solenoid interaction faces,True,assigned_and_evaluated +3451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad PNP catalytic-core activation,False,no_term_above_threshold +3452,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP enzyme middle-domain activation,False,no_term_above_threshold +3453,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidoglycan recognition and remodeling,False,no_term_above_threshold +3454,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal G/P/S repeats,False,no_term_above_threshold +3455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FabD-like AT/MAT C-terminal segment,False,no_term_above_threshold +3456,64058,17.188604,0.67089844,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6699219,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7820202534870391,0.31516339810181937,0.006202924235711121,0.21428571428571427,50.80884210827188,17.0,17.0,113.99808795411089,4.31985177778818e-35,Gfo/Idh/MocA central β-strand,True,assigned_and_evaluated +3457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended secreted low-complexity IDRs,False,no_term_above_threshold +3458,85656,25.96035,0.85302734,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.85302734,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8500952380952382,0.3081325088452672,0.0031014621178555605,0.5714285714285714,99.35072463768115,18.0,18.0,141.281990521327,9.999057839062593e-39,Hydrolase cap/lid gating,True,assigned_and_evaluated +3459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase–primase interface helices,False,no_term_above_threshold +3460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-proximal hydrophobic flanks,False,no_term_above_threshold +3461,64146,33.41266,0.9526367,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9526367,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8974244454369511,0.4996055169472813,0.007975188303057155,0.4444444444444444,62.64498065277855,17.0,17.0,66.83968609865471,3.291823951162428e-31,HTH pre-recognition helix motif,True,assigned_and_evaluated +3462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic C-terminal residues,False,no_term_above_threshold +3463,37640,29.044714,0.9951172,EF-hand domain,interpro,46081,EF-hand domain pair,0.9868164,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,14.0,0.0,1.0,Gly-aliphatic beta-strand starters,True,assigned_too_few_test_positives +3464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic core patches,False,no_term_above_threshold +3465,64026,15.712666,0.8618164,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.75878906,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9105582703983415,0.01624170211957397,0.002658396101019052,,6.109586947313074,0.0,16.0,0.0,1.0,Hydrophobic transmembrane helix core,True,assigned_and_evaluated +3466,4066,16.018631,0.7675781,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.7675781,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.49156305506216696,0.002215330084182543,0.002215330084182543,,1.0,0.0,17.0,0.0,1.0,Broad nuclease core activation,True,assigned_and_evaluated +3467,64599,17.115698,0.98046875,Chaperone J-domain superfamily,interpro,63831,F-box-like domain superfamily,0.9790039,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,12.0,12.0,662.4555555555555,3.162576276653441e-34,HPD-centered J-domain linker activation,True,assigned_too_few_test_positives +3468,58239,15.955093,0.6977539,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6977539,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7655784844384302,0.04925986638062632,0.017722640673460344,,2.7794879605268403,0.0,12.0,0.0,1.0,Beta-strand C-cap near pockets,True,assigned_and_evaluated +3469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature beta-sheet domain cores,False,no_term_above_threshold +3470,85364,17.452236,0.7128906,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7128906,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,13.0,277.95337995337997,5.938663833289501e-29,Chorismate/prephenate pathway enzymes,True,assigned_too_few_test_positives +3471,52236,20.016018,0.99072266,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98339844,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,10.0,17.0,131.35272086362633,1.3320178726118143e-19,Tetratricopeptide repeat helices,True,assigned_too_few_test_positives +3472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transducing coiled-coil linker,False,no_term_above_threshold +3473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-domain sensory coupling helices,False,no_term_above_threshold +3474,85762,28.516327,0.91308594,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9082031,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,19.0,19.0,205.58965517241379,1.005974624312525e-43,Conserved internal FAD helix motif,True,assigned_too_few_test_positives +3475,81858,16.14855,0.8671875,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6489258,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Photosynthetic RC transmembrane Fe-His motif,True,assigned_too_few_test_positives +3476,27936,18.136993,0.9194336,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.9194336,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,8.0,8.0,641.0860215053764,7.251916484533769e-23,Broad-spectrum PPIase detector,True,assigned_too_few_test_positives +3477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular low-complexity glycosylation hotspots,False,no_term_above_threshold +3478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-TM soluble catalytic band,False,no_term_above_threshold +3479,37894,16.681488,0.7792969,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7792969,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,SufB/SufD and RAD52 motifs,True,assigned_too_few_test_positives +3480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ketosynthase N-terminal dimer cap,False,no_term_above_threshold +3481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AOR/XDH cofactor-binding core,False,no_term_above_threshold +3482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MacB periplasmic loop motif,False,no_term_above_threshold +3483,87198,16.642038,0.7758789,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.7758789,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,16.0,17.0,684.3156384505021,1.128051036909839e-44,Amphipathic helical polymerization segments,True,assigned_too_few_test_positives +3484,37282,18.579718,0.9995117,Leucine-rich repeat,interpro,88009,Repeat,0.6196289,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,Canonical leucine-rich repeat scaffold,True,assigned_too_few_test_positives +3485,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF-mediated ligand sensing,False,no_term_above_threshold +3486,64475,17.604729,0.97216797,ACP-like superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.7949219,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9988687782805429,0.7018830528445913,0.0057598582188746125,1.0,121.85769617463404,0.0,15.0,0.0,1.0,Histidine kinase ATP-binding motifs,True,assigned_and_evaluated +3487,64016,36.062035,0.79785156,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.79785156,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7115555555555556,0.2728345351296171,0.0031014621178555605,0.2857142857142857,87.96964939822082,10.0,10.0,221.63940520446096,8.628605611931638e-24,Chalcogenol redox active sites,True,assigned_and_evaluated +3488,36449,19.665054,1.0,EamA domain,interpro,64026,MFS transporter superfamily,0.80126953,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,15.0,18.0,887.2172619047619,5.568290194733991e-43,Transporter transmembrane helix hotspots,True,assigned_too_few_test_positives +3489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site glutamate detector,False,no_term_above_threshold +3490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Restriction-modification DNA-binding loops,False,no_term_above_threshold +3491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RelA/SpoT TGS proximal motif,False,no_term_above_threshold +3492,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic TM boundary anchors,False,no_term_above_threshold +3493,37894,20.034145,0.9604492,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7910156,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,14.0,14.0,709.7738095238095,3.3915309155506114e-40,Dehydrogenase Tyr-centered catalytic helix,True,assigned_too_few_test_positives +3494,36104,15.596284,0.99560547,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99560547,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,N-terminal CH/helical scaffold,True,assigned_too_few_test_positives +3495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site-adjacent surface loops,False,no_term_above_threshold +3496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATF7IP CHD1 conserved motif,False,no_term_above_threshold +3497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartic protease propeptides,False,no_term_above_threshold +3498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical regions and anchor residues,False,no_term_above_threshold +3499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zn-finger modules with disordered linkers,False,no_term_above_threshold +3500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic ligand-sensing beta cores,False,no_term_above_threshold +3501,45290,31.93693,0.97216797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97216797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9601672836966955,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,17.0,17.0,73.42487684729065,6.829036441178294e-32,Kinase HRD catalytic motif,True,assigned_and_evaluated +3502,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic N-terminal scaffolding helices,False,no_term_above_threshold +3503,88058,27.21591,0.6689453,Signal,keyword,88058,Signal,0.6689453,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6724389712808813,0.12335555048714243,0.09127159946832078,,1.3515217351916529,2.0,20.0,0.7204954682779456,1.0,Cationic/hydrophobic low-complexity segments,True,assigned_and_evaluated +3504,37640,23.504797,0.9980469,EF-hand domain,interpro,46081,EF-hand domain pair,0.9916992,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,18.0,19.0,283.83443533456756,3.442883074399642e-43,EF-hand Ca2+ sensor modules,True,assigned_too_few_test_positives +3505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminus recognition,False,no_term_above_threshold +3506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic structural scaffold residues,False,no_term_above_threshold +3507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T-rich IDRs,False,no_term_above_threshold +3508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix boundary/capping residues,False,no_term_above_threshold +3509,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-to-IDR transition,False,no_term_above_threshold +3510,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged catalytic pocket scaffold,False,no_term_above_threshold +3511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid transport β-jellyroll tether,False,no_term_above_threshold +3512,36409,29.585373,0.88964844,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.88964844,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,17.0,0.0,1.0,Helix caps and boundary loops,True,assigned_too_few_test_positives +3513,81739,20.414156,0.9550781,"DNA helicase RuvA subunit, C-terminal domain",gene3d,81739,"DNA helicase RuvA subunit, C-terminal domain",0.9550781,27,gene3d,1.10.8.10,gene3d:gene3d:1.10.8.10,6.0,2257.0,0.9991115059973344,0.7271825396825395,0.002658396101019052,1.0,273.5418320105819,0.0,10.0,0.0,1.0,Basic amphipathic RNA-binding helix,True,assigned_and_evaluated +3514,85672,18.657297,0.74316406,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7373047,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.765177097403572,0.06653396758098651,0.01595037660611431,,4.171310134174626,2.0,11.0,7.275289810860281,0.04923226248110933,Surface helix-to-strand linkers,True,assigned_and_evaluated +3515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic helix/loop activation,False,no_term_above_threshold +3516,36535,20.43108,0.91845703,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.88623047,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9420783266577659,0.2203953972773073,0.004430660168365086,,49.743241165488264,0.0,10.0,0.0,1.0,ABC NBD dimerization helix,True,assigned_and_evaluated +3517,37020,16.105576,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9614258,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,20.0,735.0534246575343,7.320908339078854e-50,Glycosyltransferase donor-clamping loop,True,assigned_too_few_test_positives +3518,28679,17.130774,0.6459961,serine-type endopeptidase inhibitor activity,go_mf,28679,serine-type endopeptidase inhibitor activity,0.6459961,116,go,GO:0004867,go_mf:go:GO:0004867,6.0,2257.0,0.4893380719680142,0.002658396101019052,0.002658396101019052,,1.0,0.0,18.0,0.0,1.0,Cysteine-rich extracellular modules,True,assigned_and_evaluated +3519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tat/Sec N-terminal signal peptide,False,no_term_above_threshold +3520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory low-complexity IDRs,False,no_term_above_threshold +3521,64154,16.113176,0.9838867,Cytochrome P450 superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9477539,36,ip,IPR036396,interpro:ip:IPR036396,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,19.0,19.0,379.75159235668787,1.6383277246724524e-48,Cytochrome P450 SRS-1,True,assigned_and_evaluated +3522,49061,27.03668,0.9970703,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9970703,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9985099019419341,0.8703142354775479,0.012405848471422242,1.0,70.15354390974377,16.0,19.0,83.26228506589857,3.357512247864845e-29,beta-propeller blade-register residue,True,assigned_and_evaluated +3523,35372,19.362268,0.9916992,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9916992,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,7.0,18.0,272.77581699346405,6.951330121626393e-16,Cytosolic-end transmembrane helix marker,True,assigned_too_few_test_positives +3524,64148,29.644588,0.97998047,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9458008,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9921805183199286,0.6965160861291548,0.008418254319893664,0.5789473684210527,82.73877928386855,19.0,20.0,84.53723880597015,7.72140283526014e-36,Post-HTH alpha-beta hinge,True,assigned_and_evaluated +3525,37314,15.780076,0.9951172,"Helicase, C-terminal domain-like",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63134766,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,13.0,14.0,294.480623100304,1.1620666043554925e-31,RecA2 helicase C-terminal signature,True,assigned_too_few_test_positives +3526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane hairpin interfacial module,False,no_term_above_threshold +3527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar IDRs with homotypic motifs,False,no_term_above_threshold +3528,38873,19.699379,0.9873047,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.94873047,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9993783303730017,0.8509090909090908,0.002215330084182543,0.8,384.1003636363636,12.0,13.0,158.14588859416446,5.249804304397507e-26,Walker A P-loop motif,True,assigned_and_evaluated +3529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long helical assembly segments,False,no_term_above_threshold +3530,85649,25.825588,0.79833984,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7949219,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7086722976917986,0.2135909861061035,0.0101905183872397,0.30434782608695654,20.959776332238068,3.0,12.0,27.65352504638219,0.00027592779758915,SAM-adjacent catalytic loop,True,assigned_and_evaluated +3531,64155,21.134592,0.7680664,Ribonuclease H superfamily,interpro,64155,Ribonuclease H superfamily,0.7680664,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,11.0,13.0,234.6443649373882,2.4541363569663023e-25,Catalytic domain entry cap,True,assigned_too_few_test_positives +3532,88161,46.62608,0.62890625,Transmembrane helix,keyword,88161,Transmembrane helix,0.62890625,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6218525179856115,0.3459662812775492,0.1847585290208241,0.2805755395683453,1.8725321267228503,20.0,20.0,5.4274920345926265,4.680596445535425e-15,Disordered cytosolic juxtamembrane tails,True,assigned_and_evaluated +3533,85675,22.459192,0.93359375,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9135742,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,0.0,11.0,0.0,1.0,Divalent cation site scaffolds,True,assigned_too_few_test_positives +3534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prenyl diphosphate-binding helical core,False,no_term_above_threshold +3535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL ATPase and regulatory modules,False,no_term_above_threshold +3536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface beta-edge binding patches,False,no_term_above_threshold +3537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase palm hydrophobic motif,False,no_term_above_threshold +3538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Second shell pocket scaffold,False,no_term_above_threshold +3539,59229,31.249226,0.98046875,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98046875,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9014440854774046,0.7460455502639317,0.0101905183872397,0.7391304347826086,73.20977421503017,16.0,16.0,106.27629233511585,1.339381655082284e-32,SAM-binding acidic beta-strand,True,assigned_and_evaluated +3540,85675,22.551893,0.95214844,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.93066406,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,15.0,17.0,482.63086886130594,3.2485596392672056e-39,Acidic VWA-like binding surfaces,True,assigned_too_few_test_positives +3541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible solvent-exposed loops/linkers,False,no_term_above_threshold +3542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme catalytic domain helical scaffolds,False,no_term_above_threshold +3543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-coil linkers,False,no_term_above_threshold +3544,64003,20.410898,0.9980469,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.8623047,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,16.0,16.0,130.4617067833698,5.252801912935239e-34,C2H2 finger start residue,True,assigned_and_evaluated +3545,36354,16.781307,0.97021484,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.95703125,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,16.0,0.0,1.0,Beta-alpha junction polar motif,True,assigned_too_few_test_positives +3546,36115,20.465815,0.9980469,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9980469,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,16.0,19.0,311.8457012095456,2.4909173293642985e-38,BTB/POZ CUL3 binding interface,True,assigned_too_few_test_positives +3547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Gly/basic helix-capping loops,False,no_term_above_threshold +3548,59229,16.079916,0.8251953,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8066406,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8497041765598847,0.044505234839994356,0.0101905183872397,,4.36731804495075,1.0,15.0,7.08508615567439,0.21140060526477727,Metal-site G–D flanks,True,assigned_and_evaluated +3549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane transport module,False,no_term_above_threshold +3550,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Branched hydrophobic beta-strand motif,False,no_term_above_threshold +3551,36914,20.61261,0.96533203,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.96533203,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,16.0,0.0,1.0,HK CA-domain hydrophobic hotspot,True,assigned_too_few_test_positives +3552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP active-site loop,False,no_term_above_threshold +3553,64058,19.197271,0.86572266,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8496094,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9694605439144004,0.1370725669085952,0.006202924235711121,,22.098055965192813,0.0,17.0,0.0,1.0,Pocket bordering glycine beta-strands,True,assigned_and_evaluated +3554,87489,19.965471,0.8388672,GPI-anchor,keyword,88058,Signal,0.6113281,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9132698412698412,0.1235978856036715,0.0031014621178555605,,39.8514896867838,7.0,18.0,57.249245541838135,4.0476710979965634e-11,Fungal extracellular S/T-rich IDRs,True,assigned_and_evaluated +3555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic nucleic-acid clamp helices,False,no_term_above_threshold +3556,84753,18.10441,0.7089844,3.30.420.40,gene3d,84753,3.30.420.40,0.7089844,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,17.0,17.0,414.03472222222223,2.235346372079017e-44,Carbohydrate kinase catalytic core,True,assigned_too_few_test_positives +3557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal basic nucleic acid wedge,False,no_term_above_threshold +3558,87276,43.973938,0.73095703,Cell membrane,keyword,88161,Transmembrane helix,0.7089844,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8083071502623602,0.5039432671647601,0.11120957022596367,0.6772908366533864,4.531473920282325,8.0,17.0,3.861401207881997,0.0007540417261158168,TM N-cap loop-to-helix motif,True,assigned_and_evaluated +3559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity proline/FG IDRs,False,no_term_above_threshold +3560,38873,21.285398,0.8564453,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7089844,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9966252220248668,0.5805860805860805,0.002215330084182543,0.4,262.07655677655674,10.0,10.0,171.32471264367817,1.12424031081604e-22,ABC ATPase H-loop switch,True,assigned_and_evaluated +3561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix capping segments,False,no_term_above_threshold +3562,36499,24.304144,0.7973633,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.7973633,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,18.0,0.0,1.0,HAMP sensory relay linkers,True,assigned_too_few_test_positives +3563,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter transmembrane helices,False,no_term_above_threshold +3564,47529,19.931076,0.6953125,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6953125,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7442269076305222,0.20134672593688988,0.007089056269384138,0.0625,28.40247252747253,4.0,15.0,20.621184608733248,6.235069113884945e-05,Ectodomain alpha-beta junction motifs,True,assigned_and_evaluated +3565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Organelle type I signal peptidase,False,no_term_above_threshold +3566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/neck oligomerization scaffolds,False,no_term_above_threshold +3567,55053,22.048119,0.98535156,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,13.0,552.0462962962963,5.9319613712133276e-36,NRPS condensation catalytic loop,True,assigned_too_few_test_positives +3568,64620,17.653217,0.8691406,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.8691406,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,15.0,17.0,285.90632992327363,9.010865335320971e-36,Charged nucleotide-binding regulatory linkers,True,assigned_too_few_test_positives +3569,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated noncatalytic scaffold linkers,False,no_term_above_threshold +3570,50338,16.18695,0.9902344,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.67041016,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,13.0,0.0,1.0,Transmembrane helix boundary caps,True,assigned_too_few_test_positives +3571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane pore/channel motif,False,no_term_above_threshold +3572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic soluble domain scaffold,False,no_term_above_threshold +3573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic and G-patch hotspots,False,no_term_above_threshold +3574,87326,30.732742,0.64501953,Coiled coil,keyword,87326,Coiled coil,0.64501953,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6288636552095859,0.25325646176209177,0.03943287549844927,0.23595505617977527,6.422470047157765,17.0,17.0,12.607528018608585,4.8104034305401955e-19,Coiled-coil-adjacent polar IDRs,True,assigned_and_evaluated +3575,46081,16.839195,0.64453125,EF-hand domain pair,interpro,46081,EF-hand domain pair,0.64453125,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.5510782570031125,0.0075657478321412746,0.003544528134692069,,2.134486607142857,1.0,15.0,17.058941344778255,0.09379835060400689,Boundary linchpin residue detector,True,assigned_and_evaluated +3576,49061,19.564714,0.8696289,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8696289,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9247660706274434,0.12322906478988727,0.012405848471422242,,9.933142829670556,5.0,17.0,29.080577504633695,1.1255976555802215e-06,Beta-strand terminus detector,True,assigned_and_evaluated +3577,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type II Golgi luminal N-termini,False,no_term_above_threshold +3578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal amphipathic oligomerization segments,False,no_term_above_threshold +3579,88263,32.325867,0.89941406,Zinc-finger,keyword,88058,Signal,0.78027344,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9214900806627426,0.08170080320792492,0.014621178555604785,,5.587839783038986,6.0,19.0,8.228882959146116,0.0001027630226955356,Propeptide motifs; CW zinc finger,True,assigned_and_evaluated +3580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic alpha/beta scaffold,False,no_term_above_threshold +3581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane catalytic loops,False,no_term_above_threshold +3582,39958,18.579905,0.8383789,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8383789,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.994854138901229,0.22639933166248957,0.002658396101019052,,85.16388192703982,0.0,17.0,0.0,1.0,Coiled-coil heptad linkers,True,assigned_and_evaluated +3583,47529,15.734224,0.7236328,Immunoglobulin-like fold,interpro,88161,Transmembrane helix,0.61279297,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7597333779562695,0.14516073751029143,0.007089056269384138,0.0625,20.476736535045486,12.0,18.0,51.55296152183312,8.732053544364814e-19,Single-pass type I transmembrane helix,True,assigned_and_evaluated +3584,72011,18.776495,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.921875,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,15.0,15.0,590.3069306930694,9.761613975691778e-42,ANL A-domain active-site motif,True,assigned_too_few_test_positives +3585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand boundary motif,False,no_term_above_threshold +3586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed xNGx/xDGx loop motifs,False,no_term_above_threshold +3587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RFTS-BAH with Cys-Zn linker,False,no_term_above_threshold +3588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VFT/PBP ligand-binding hinge/cleft,False,no_term_above_threshold +3589,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Y-family polymerase DNA-binding activation,False,no_term_above_threshold +3590,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal amphipathic capping helix,False,no_term_above_threshold +3591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted disulfide-rich and AroQ,False,no_term_above_threshold +3592,85664,22.33881,0.97998047,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.97998047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycosyltransferase internal hydrophobic helix,True,assigned_too_few_test_positives +3593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad activation C-terminal peaks,False,no_term_above_threshold +3594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transporter TM helices,False,no_term_above_threshold +3595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-start alpha helix seed,False,no_term_above_threshold +3596,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phycobilisome linker cationic patches,False,no_term_above_threshold +3597,37894,17.069063,0.95751953,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.87060547,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,19.0,0.0,1.0,SDR Ser–YxxxK catalytic loop,True,assigned_too_few_test_positives +3598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic glycine-rich gating loops,False,no_term_above_threshold +3599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Globular domain hydrophobic core,False,no_term_above_threshold +3600,85364,25.999914,0.9658203,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9658203,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Venus flytrap ligand-binding loops,True,assigned_too_few_test_positives +3601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SEC23/24 gelsolin-like helix,False,no_term_above_threshold +3602,25169,21.521334,0.9223633,pilus,go_cc,25169,pilus,0.9223633,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9960923623445825,0.7808333333333333,0.002215330084182543,0.8,352.46816666666666,19.0,20.0,524.4439814814814,3.3514965219126157e-50,Chaperone-usher pilin/adhesin domain,True,assigned_and_evaluated +3603,81858,17.358429,0.7651367,Rhodopsin 7-helix transmembrane proteins,gene3d,28715,G protein-coupled receptor activity,0.7626953,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,N-terminal TM1 signal-anchor,True,assigned_too_few_test_positives +3604,88058,26.78781,0.6665039,Signal,keyword,88058,Signal,0.6665039,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6768164239087728,0.12466103317096369,0.09127159946832078,,1.3658250090624517,1.0,19.0,0.3792081411989187,1.0,Acidic Pro/Ser-rich disordered regions,True,assigned_and_evaluated +3605,87857,20.187107,0.6586914,Nucleus,keyword,87857,Nucleus,0.6586914,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.718435359101208,0.15400385091666574,0.06247230837394772,,2.465153840559678,11.0,20.0,3.332474593495935,0.00017396135020805153,Acidic PEST-like IDRs,True,assigned_and_evaluated +3606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal linkers and propeptides,False,no_term_above_threshold +3607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich disordered linkers,False,no_term_above_threshold +3608,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved beta-sandwich turn motif,False,no_term_above_threshold +3609,88154,17.405447,0.83447266,Transit peptide,keyword,88154,Transit peptide,0.83447266,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.7861527839976117,0.026809890502136183,0.010633584404076208,,2.5212467859717234,2.0,18.0,3.2441506148655996,0.2004979407229864,Position-2 N-terminus residue detector,True,assigned_and_evaluated +3610,48241,15.604664,0.98535156,RmlC-like jelly roll fold,interpro,46082,PH-like domain superfamily,0.9169922,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,17.0,18.0,365.6410533910534,9.425704243737979e-43,Aromatic cupin cavity strands,True,assigned_too_few_test_positives +3611,45290,32.787617,0.9746094,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9746094,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9605786370492253,0.9176028293304457,0.0057598582188746125,0.9230769230769231,159.30996813837044,17.0,17.0,73.42487684729065,6.829036441178294e-32,Conserved kinase αE helix,True,assigned_and_evaluated +3612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid pocket-rim loop motifs,False,no_term_above_threshold +3613,87409,18.426865,0.7597656,Dioxygenase,keyword,87409,Dioxygenase,0.7597656,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,10.0,11.0,254.46436192915064,8.756408854128775e-24,Non-heme Fe oxygenase C-termini,True,assigned_too_few_test_positives +3614,88153,17.175627,0.6508789,Transferase,keyword,87601,Hydrolase,0.62841797,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.6799412000534545,0.131782350134865,0.052724856003544526,,2.4994349937343725,4.0,12.0,3.7818585474151596,0.028300343981817213,Phosphate-binding loop motif,True,assigned_and_evaluated +3615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed alpha/beta C-terminal hotspot,False,no_term_above_threshold +3616,88164,20.038883,0.77978516,Transposition,keyword,88164,Transposition,0.77978516,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.5953818827708703,0.20177226406734605,0.002215330084182543,0.2,91.08000000000001,1.0,20.0,36.35426829268293,0.04534455087147504,Nucleic acid enzyme catalytic grooves,True,assigned_and_evaluated +3617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease active-site cleft loops,False,no_term_above_threshold +3618,59229,27.194202,0.7651367,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7651367,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8545696936670429,0.31441460788245534,0.0101905183872397,0.34782608695652173,30.853642173508767,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Noncatalytic N-termini of SAM enzymes,True,assigned_and_evaluated +3619,84152,22.519556,0.8886719,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8886719,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,17.0,0.0,1.0,TIM barrel catalytic core,True,assigned_too_few_test_positives +3620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C luminal catalytic loop,False,no_term_above_threshold +3621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cupin-like PsbP beta-strand motif,False,no_term_above_threshold +3622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass transmembrane helix bundles,False,no_term_above_threshold +3623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HPPK C-terminal helical region,False,no_term_above_threshold +3624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF sensor with helical cross-activation,False,no_term_above_threshold +3625,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphoglycerol transferase I C-terminal loop,False,no_term_above_threshold +3626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acyl-CoA-binding α/β core,False,no_term_above_threshold +3627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant ACA N-terminal autoinhibitory region,False,no_term_above_threshold +3628,36876,20.652227,1.0,Cytochrome P450,interpro,64154,Cytochrome P450 superfamily,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,11.0,11.0,389.6797385620915,7.778518666786477e-29,Cytochrome P450 catalytic domain,True,assigned_and_evaluated +3629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent phosphate/diphosphate catalysis,False,no_term_above_threshold +3630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and loops,False,no_term_above_threshold +3631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDR tails flanking binding cores,False,no_term_above_threshold +3632,55054,25.787025,0.9873047,HAD superfamily,interpro,55054,HAD superfamily,0.9873047,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8978241563055064,0.7147287803025508,0.002215330084182543,0.8,322.6285714285715,19.0,19.0,334.9494382022472,1.6151862494317167e-47,Acidic metal-binding catalytic loop,True,assigned_and_evaluated +3633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PRY/SPRY beta-sandwich and S/P/G linkers,False,no_term_above_threshold +3634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-wall glycan hydrolase loops,False,no_term_above_threshold +3635,88058,38.09028,0.62060547,Signal,keyword,88058,Signal,0.62060547,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5770355923939542,0.19640746051361713,0.09127159946832078,0.11650485436893204,2.1519011571807467,17.0,19.0,6.446538400381619,7.432889592374928e-13,Classical N-terminal targeting signals,True,assigned_and_evaluated +3636,36010,16.05834,0.9951172,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9453125,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,16.0,20.0,407.6649572649573,6.600845995483126e-40,ABH catalytic His loop-helix,True,assigned_too_few_test_positives +3637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Post-DDE hydrophobic clusters, acidic IDRs",False,no_term_above_threshold +3638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta strand pocket lining,False,no_term_above_threshold +3639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electrostatic surface loop patches,False,no_term_above_threshold +3640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic anionic substrate-binding loops,False,no_term_above_threshold +3641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ssDNA primase/Prim-Pol core,False,no_term_above_threshold +3642,88058,19.530252,0.6191406,Signal,keyword,88058,Signal,0.6191406,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6404559935243525,0.1134004921422529,0.09127159946832078,,1.2424510231313826,3.0,19.0,1.137624423596756,0.7800416838874774,Gly/Ala/Pro-rich disordered segments,True,assigned_and_evaluated +3643,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-ribose catalytic core,False,no_term_above_threshold +3644,81799,17.870157,0.9819336,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7050781,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,13.0,14.0,537.498613037448,4.0609734963804503e-35,AAA+ signature helix,True,assigned_too_few_test_positives +3645,45324,18.088837,0.9736328,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.7524414,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.997424511545293,0.33415584415584415,0.002215330084182543,,150.83794805194805,3.0,17.0,96.5261737722612,7.4946657197244176e-06,Extracellular beta-repeat scaffolds,True,assigned_and_evaluated +3646,38317,24.024525,0.8100586,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8100586,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7801904761904762,0.09030805545041956,0.0031014621178555605,,29.117897307370992,0.0,9.0,0.0,1.0,Signal-transducing coiled-coil stalks,True,assigned_and_evaluated +3647,85656,17.817923,0.93896484,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8618164,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9704126984126984,0.07045045117892075,0.0031014621178555605,,22.71523833011773,1.0,18.0,7.848999473407056,0.19288573788380464,Active site adjacent capping segments,True,assigned_and_evaluated +3648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic interface scaffolds,False,no_term_above_threshold +3649,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AddB nuclease β-strand motif,False,no_term_above_threshold +3650,85762,23.122368,0.70214844,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.69628906,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,13.0,13.0,205.58965517241379,2.4985932607894418e-30,Substrate-gating redox lid loops,True,assigned_too_few_test_positives +3651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic and tail modules,False,no_term_above_threshold +3652,37341,22.503115,0.99609375,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9916992,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9998173060953329,0.9846344629430862,0.011962782454585734,1.0,82.30814751342761,18.0,19.0,137.76354300385108,1.0024362880238542e-37,Propeller blade-start GH loop,True,assigned_and_evaluated +3653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal repeat-boundary signature,False,no_term_above_threshold +3654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Terminal IDR activation, core deactivation",False,no_term_above_threshold +3655,85649,19.65289,0.7729492,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.7729492,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8361391148651279,0.08208415892799681,0.0101905183872397,,8.054954204369077,0.0,8.0,0.0,1.0,Sigma70 region-2 amphipathic helices,True,assigned_and_evaluated +3656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Type III/flagellar export signal,False,no_term_above_threshold +3657,38873,16.306028,0.9711914,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9550781,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9893428063943162,0.3906207827260459,0.002215330084182543,0.4,176.32622132253712,5.0,18.0,47.59019795657727,1.0483522124289778e-07,Walker A P-loop motif,True,assigned_and_evaluated +3658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding hairpin/loop surfaces,False,no_term_above_threshold +3659,87326,24.257933,0.6611328,Coiled coil,keyword,87326,Coiled coil,0.6611328,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6651213773373689,0.100256653010548,0.03943287549844927,0.011235955056179775,2.542463661177605,10.0,16.0,7.8797050116303655,9.899978222928872e-08,Amphipathic coiled-coil interaction helices,True,assigned_and_evaluated +3660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity basic IDRs and micro-TMs,False,no_term_above_threshold +3661,87239,16.516119,0.78222656,CF(1),keyword,87239,CF(1),0.78222656,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9973848904783192,0.6060233420793766,0.008861320336730172,1.0,68.38973415365766,0.0,17.0,0.0,1.0,Cupin/JmjC oxygenase catalytic barrel,True,assigned_and_evaluated +3662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged IDR tails with motifs,False,no_term_above_threshold +3663,82029,19.222784,0.8823242,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69384766,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,Non-transmembrane loops/tails,True,assigned_too_few_test_positives +3664,87326,40.077873,0.7949219,Coiled coil,keyword,87326,Coiled coil,0.7949219,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8194032712799038,0.28039141686999014,0.03943287549844927,0.30337078651685395,7.110600313208627,11.0,17.0,8.157812247334968,1.2325868298949e-08,Coiled-coil oligomerization motifs,True,assigned_and_evaluated +3665,88058,16.122772,0.60009766,Signal,keyword,88058,Signal,0.60009766,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5543613581818956,0.09596879211735973,0.09127159946832078,,1.0514639019848588,10.0,14.0,5.1463962019853255,2.9526474275596e-06,C-terminal hydroxyproline-rich disorder,True,assigned_and_evaluated +3666,36535,21.435902,0.93408203,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.91259766,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9469292389853137,0.8793319549057254,0.004430660168365086,0.9,198.46522222222222,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Kinase C-lobe activation patch,True,assigned_and_evaluated +3667,39971,17.299417,0.9379883,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.92089844,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,6.0,18.0,220.81851851851852,4.0831257502349435e-13,Subtilisin NxS(F/L/Y)G motif,True,assigned_too_few_test_positives +3668,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic–hydrophobic catalytic cavities,False,no_term_above_threshold +3669,36914,16.966766,0.96875,Glycosyltransferase 2-like,interpro,63774,RNA-binding domain superfamily,0.9135742,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,13.0,0.0,1.0,ABC ATPase NBD start,True,assigned_too_few_test_positives +3670,88058,21.656994,0.6333008,Signal,keyword,88058,Signal,0.6333008,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6207201791217165,0.11187632272696296,0.09127159946832078,,1.225751749489104,1.0,20.0,0.3602477341389728,1.0,Terminal disordered peptide detector,True,assigned_and_evaluated +3671,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NADPH reductase Rossmann lobe,False,no_term_above_threshold +3672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prenyl-diphosphate binding pocket,False,no_term_above_threshold +3673,59229,17.519035,0.6347656,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6347656,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.724407380016348,0.2784843032323342,0.0101905183872397,0.30434782608695654,27.327785756320793,14.0,18.0,82.6593384828679,3.2588818678694394e-25,Nucleic acid MTases and THUMP,True,assigned_and_evaluated +3674,37894,16.379799,0.98339844,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.96240234,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Rossmann pyrophosphate-binding loops,True,assigned_too_few_test_positives +3675,87326,22.039413,0.61621094,Coiled coil,keyword,87326,Coiled coil,0.61621094,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6375834404411459,0.0947169986644742,0.03943287549844927,,2.4019805166934636,7.0,18.0,4.902927562792228,0.0005121872646802977,Leucine-zipper coiled-coil helix,True,assigned_and_evaluated +3676,36776,16.153233,0.9873047,SANT/Myb domain,interpro,87384,DNA-binding,0.70751953,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.974788982674367,0.05551762387442856,0.002658396101019052,,20.883879514097544,0.0,19.0,0.0,1.0,Short amphipathic interface helices,True,assigned_and_evaluated +3677,47128,28.075235,0.85595703,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.85595703,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,8.0,14.0,146.84975369458127,3.2812974634399e-16,Extracellular non-catalytic glycan-binding domains,True,assigned_too_few_test_positives +3678,61392,26.24863,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,15.0,15.0,167.4747191011236,1.5239103019764629e-33,LRR register detector,True,assigned_and_evaluated +3679,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic helix N-cap motifs,False,no_term_above_threshold +3680,85649,36.753998,0.828125,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.828125,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7793585302245922,0.5631979798052498,0.0101905183872397,0.5652173913043478,55.26686262697603,15.0,15.0,110.61410018552876,7.1622047874657735e-31,Class I SAM MTase core,True,assigned_and_evaluated +3681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD Q/A-loop motif,False,no_term_above_threshold +3682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge anion-binding SLiMs,False,no_term_above_threshold +3683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coils and catalytic/hinge residues,False,no_term_above_threshold +3684,49061,34.03229,0.9707031,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9707031,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9957700442222649,0.5583637060867672,0.012405848471422242,1.0,45.00810302277977,3.0,16.0,18.53886815920398,0.0009274250120253182,Aromatic-Gly beta-propeller motifs,True,assigned_and_evaluated +3685,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity N-termini and helical repeats,False,no_term_above_threshold +3686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular juxtamembrane boundary,False,no_term_above_threshold +3687,36914,17.589542,0.9003906,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.9003906,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,18.0,654.2770919067215,7.094834976616662e-44,Membrane-interface glycan-binding loop,True,assigned_too_few_test_positives +3688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich catalytic cores,False,no_term_above_threshold +3689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHp/HisKA phosphoacceptor helix,False,no_term_above_threshold +3690,36091,25.986746,0.9995117,GNAT domain,interpro,85712,3.40.630.30,0.95947266,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,19.0,0.0,1.0,HATPase_c ATP-lid glycine loop,True,assigned_too_few_test_positives +3691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease post-TM1 loop,False,no_term_above_threshold +3692,64168,18.541544,0.85253906,HAD-like superfamily,interpro,55054,HAD superfamily,0.84375,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.794671403197158,0.25490912053942016,0.002215330084182543,0.4,115.06597701149427,0.0,15.0,0.0,1.0,Radical SAM core activation,True,assigned_and_evaluated +3693,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic and intramembrane catalytic domains,False,no_term_above_threshold +3694,36010,17.133392,0.921875,Alpha/beta hydrolase fold-1,interpro,36010,Alpha/beta hydrolase fold-1,0.921875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,19.0,0.0,1.0,FG-rich low-complexity IDRs,True,assigned_too_few_test_positives +3695,36010,19.66338,0.99658203,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.75146484,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,18.0,18.0,509.58119658119665,2.3458872067348707e-48,AB hydrolase cap helix,True,assigned_too_few_test_positives +3696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic cystathionine PLP motifs,False,no_term_above_threshold +3697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory hydrophobic beta-strands,False,no_term_above_threshold +3698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hot-dog fold acyl-thioester enzymes,False,no_term_above_threshold +3699,87326,33.91105,0.69433594,Coiled coil,keyword,87326,Coiled coil,0.69433594,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6821929806376716,0.28912694560987984,0.03943287549844927,0.23595505617977527,7.332129395971897,18.0,19.0,11.943973912366028,6.647492796621427e-19,Coiled-coil ionic stripe,True,assigned_and_evaluated +3700,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical assembly domain,False,no_term_above_threshold +3701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Argonaute/PIWI endonuclease scaffold,False,no_term_above_threshold +3702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory CAZyme catalytic cores,False,no_term_above_threshold +3703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Organelle mature domain activator,False,no_term_above_threshold +3704,28025,17.049986,0.88623047,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.67529297,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9128165259884496,0.47187163744540794,0.002658396101019052,0.8333333333333334,177.50238095238095,13.0,17.0,207.23877005347592,1.3388894267222188e-28,Ras-like G-domain inter-motif core,True,assigned_and_evaluated +3705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and tails,False,no_term_above_threshold +3706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase active-site loops,False,no_term_above_threshold +3707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil and TM helix boundaries,False,no_term_above_threshold +3708,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIR/SEFIR C-terminal signaling interface,False,no_term_above_threshold +3709,37020,17.799025,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9892578,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,20.0,735.0534246575343,7.320908339078854e-50,N-terminal active-site rim loop,True,assigned_too_few_test_positives +3710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small alpha/beta cavity cores,False,no_term_above_threshold +3711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich scaffold IDRs,False,no_term_above_threshold +3712,87697,21.902308,0.8876953,Knottin,keyword,87697,Knottin,0.8876953,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9296894869482787,0.10817709945550646,0.017279574656623838,,6.260402909514823,0.0,18.0,0.0,1.0,Binding pocket boundary residues,True,assigned_and_evaluated +3713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Distal ancillary regulatory domains,False,no_term_above_threshold +3714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal membrane-proximal tails,False,no_term_above_threshold +3715,85672,47.190044,0.9248047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9199219,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9092938616238931,0.5721594820112917,0.01595037660611431,0.6666666666666666,35.87122085831904,16.0,16.0,40.01409395973155,6.696154575406941e-26,Helicase P-loop helix,True,assigned_and_evaluated +3716,36091,27.29389,0.9892578,GNAT domain,interpro,85712,3.40.630.30,0.98339844,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,16.0,20.0,301.87848101265826,8.607230507722565e-38,Acyltransferase active-site rim helix/loop,True,assigned_too_few_test_positives +3717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane boundary motif,False,no_term_above_threshold +3718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfotransferase and glycosyltransferase catalytic domains,False,no_term_above_threshold +3719,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Processed hydrolase Gly-rich helix,False,no_term_above_threshold +3720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BED/hAT C-terminal activation,False,no_term_above_threshold +3721,52940,15.787721,0.9628906,"AMP-binding, conserved site",interpro,36668,AMP-dependent synthetase/ligase domain,0.8852539,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,18.0,0.0,1.0,Peptidoglycan/chitin glycan-binding groove,True,assigned_too_few_test_positives +3722,87276,34.835968,0.66308594,Cell membrane,keyword,88161,Transmembrane helix,0.640625,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.758253129059038,0.41586728273177975,0.11120957022596367,0.5657370517928287,3.7394918610582746,6.0,17.0,2.8960509059114976,0.02080523942261121,Pre-transmembrane soluble segment,True,assigned_and_evaluated +3723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular protease bait activation,False,no_term_above_threshold +3724,72011,17.447136,0.84765625,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.84765625,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,11.0,0.0,1.0,Active-site α/β pocket segment,True,assigned_too_few_test_positives +3725,64085,24.310703,0.83691406,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7993164,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.6685252835993079,0.21555787655077002,0.012405848471422242,0.25,17.375504549110282,17.0,17.0,117.59566074950689,2.5781503466722103e-35,Dynein IC light-chain-binding region,True,assigned_and_evaluated +3726,64146,18.541792,0.8144531,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8144531,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8974244454369511,0.038204041233706486,0.007975188303057155,,4.790362281359752,0.0,13.0,0.0,1.0,Noncatalytic alpha-helical scaffold residues,True,assigned_and_evaluated +3727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic boundary hinge motifs,False,no_term_above_threshold +3728,85656,17.557266,0.94970703,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7680664,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9854285714285715,0.10076687844185112,0.0031014621178555605,,32.490120663322564,0.0,17.0,0.0,1.0,Catalytic rim and linker loops,True,assigned_and_evaluated +3729,64148,27.434206,0.95654297,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9223633,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9865363811673957,0.6749599502266833,0.008418254319893664,0.631578947368421,80.17813724534865,19.0,19.0,88.9865671641791,4.383349844353145e-37,Winged-helix β-wing strand,True,assigned_and_evaluated +3730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Deubiquitinase UBL-binding surfaces,False,no_term_above_threshold +3731,38878,18.055956,0.9902344,Immunoglobulin subtype,interpro,63951,Immunoglobulin-like domain superfamily,0.9814453,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,3.0,19.0,35.25783560023654,0.0001491011640373528,Glycosylated ectodomain loops,True,assigned_too_few_test_positives +3732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary/capping signal,False,no_term_above_threshold +3733,38873,17.446955,0.8769531,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77490234,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.694271758436945,0.40132919805050954,0.002215330084182543,0.4,181.16000000000003,10.0,11.0,155.74973876698013,1.1974008580911447e-21,AAA+ boundary hinge loops,True,assigned_and_evaluated +3734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter transmembrane helices,False,no_term_above_threshold +3735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic linker helices,False,no_term_above_threshold +3736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic cell-wall glycan enzymes,False,no_term_above_threshold +3737,87419,16.520685,0.9121094,EGF-like domain,keyword,87419,EGF-like domain,0.9121094,54,keywords,EGF-like domain,keyword:keywords:EGF-like domain,,,,,,,,0.0,15.0,0.0,1.0,Collagen triple-helix glycine detector,True,assigned_too_few_test_positives +3738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic proline-rich tails,False,no_term_above_threshold +3739,69992,17.136202,0.9658203,"Peptidase S1, PA clan, chymotrypsin-like fold",interpro,37071,Homeodomain,0.8984375,38,ip,IPR043504,interpro:ip:IPR043504,10.0,2257.0,0.9995549621717845,0.7980122655122655,0.004430660168365086,1.0,180.11136832611834,9.0,10.0,425.8642857142857,1.8023084951337572e-23,Trypsin-fold glycine-rich hairpin,True,assigned_and_evaluated +3740,87277,16.757807,0.68066406,Cell outer membrane,keyword,25167,cell outer membrane,0.6777344,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.7096507936507936,0.11996954297891065,0.0031014621178555605,,38.68160835762876,20.0,20.0,146.4889434889435,4.491295642525102e-43,Cleavable N-terminal targeting peptides,True,assigned_and_evaluated +3741,30856,15.7508135,0.7675781,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.61865234,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.8484902309058614,0.033646159219929715,0.002215330084182543,,15.187876271876274,4.0,16.0,33.49494382022472,9.767795153881004e-06,Lipid-exposed transmembrane helices,True,assigned_and_evaluated +3742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD structural beta strands,False,no_term_above_threshold +3743,59224,28.934994,0.98535156,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.98535156,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9999365079365079,0.982142857142857,0.0031014621178555605,1.0,316.67091836734687,18.0,18.0,137.37557603686636,1.6332112516921354e-38,AB hydrolase glycine-loop signature,True,assigned_and_evaluated +3744,36668,16.216652,0.9628906,AMP-dependent synthetase/ligase domain,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.77734375,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,16.0,0.0,1.0,Rossmann loop-adjacent helix,True,assigned_too_few_test_positives +3745,85649,15.773615,0.6152344,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6142578,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6056595694990463,0.19855489844798468,0.0101905183872397,0.21739130434782608,19.484278512917452,11.0,15.0,81.11700680272108,1.0142438229927752e-19,Activated C-terminal recognition tails,True,assigned_and_evaluated +3746,64317,17.525156,0.90283203,"Knottin, scorpion toxin-like superfamily",interpro,64317,"Knottin, scorpion toxin-like superfamily",0.90283203,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,19.0,0.0,1.0,Short amphipathic alpha-helices,True,assigned_too_few_test_positives +3747,45272,15.786078,0.67089844,"Lambda repressor-like, DNA-binding domain superfamily",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.67089844,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,0.0,18.0,0.0,1.0,Conserved functional residue peaks,True,assigned_too_few_test_positives +3748,87601,17.655956,0.63671875,Hydrolase,keyword,87601,Hydrolase,0.63671875,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.607859538293558,0.11289595858804238,0.05316792202038104,,2.123384821110097,1.0,14.0,0.7988450304150922,1.0,GTP PEPCK dual motif signature,True,assigned_and_evaluated +3749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"ZU5 domains, bacterial mature segments",False,no_term_above_threshold +3750,64016,21.013758,0.9741211,Thioredoxin-like superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.79248047,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9858095238095238,0.5254740564599719,0.0031014621178555605,0.8571428571428571,169.42784934716522,6.0,17.0,78.22567242510387,1.9897248069402218e-10,Polar β→α N-cap motifs,True,assigned_and_evaluated +3751,82107,19.317013,0.70751953,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.7011719,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,11.0,0.0,1.0,Acidic Mg2+-phosphate-binding loop,True,assigned_too_few_test_positives +3752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved secondary-structure boundary motifs,False,no_term_above_threshold +3753,59229,32.55232,0.98046875,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98046875,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8613327624459927,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,17.0,17.0,106.27629233511585,1.3819031749869367e-34,SAM-binding motif I β-strand,True,assigned_and_evaluated +3754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible helical interdomain linkers,False,no_term_above_threshold +3755,88058,20.32021,0.62646484,Signal,keyword,87760,Membrane,0.6064453,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5926057854799696,0.11109091386639311,0.09127159946832078,,1.2171465660021807,11.0,18.0,4.403027861698557,8.511586651843103e-06,C-terminus or peptide-end detector,True,assigned_and_evaluated +3756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral amphipathic segments,False,no_term_above_threshold +3757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AMP-forming adenylation ATP-PPase core,False,no_term_above_threshold +3758,42054,18.623001,0.99902344,Radical SAM,interpro,42054,Radical SAM,0.99902344,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,15.0,16.0,635.1669034090909,1.63611461399762e-41,Radical SAM C-terminal cap,True,assigned_too_few_test_positives +3759,38873,21.710424,0.9770508,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8808594,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.997335701598579,0.6921052631578948,0.002215330084182543,0.6,312.41631578947374,11.0,11.0,171.32471264367817,6.880872708632078e-25,Post-Walker A connector loop,True,assigned_and_evaluated +3760,87697,22.929405,0.8833008,Knottin,keyword,87697,Knottin,0.8833008,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9251115581142632,0.10143037307633357,0.017279574656623838,,5.869957744443202,0.0,17.0,0.0,1.0,Arg/Lys beta-strand core motif,True,assigned_and_evaluated +3761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core aromatic packing anchors,False,no_term_above_threshold +3762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FLDHR-like SAM methyltransferase motif,False,no_term_above_threshold +3763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Clan CD protease core,False,no_term_above_threshold +3764,37341,28.219282,0.99560547,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9560547,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,15.0,15.0,145.4170731707317,1.2445568601222044e-32,WD propeller terminal IDRs,True,assigned_and_evaluated +3765,87149,17.513899,0.62402344,Amphibian defense peptide,keyword,87162,Antimicrobial,0.6064453,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6950025636095624,0.04636515694976327,0.012405848471422242,,3.737362829843418,0.0,17.0,0.0,1.0,ApoL pore-forming amphipathic helices,True,assigned_and_evaluated +3766,45324,17.72645,0.9785156,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.8510742,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9997335701598579,0.8766666666666667,0.002215330084182543,1.0,395.7273333333334,3.0,18.0,91.16360856269112,8.954875466409747e-06,Secreted β-helix/solenoid repeats,True,assigned_and_evaluated +3767,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal ILVELG[K/R/H]RR helix,False,no_term_above_threshold +3768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent subsite loops,False,no_term_above_threshold +3769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic TM-boundary loop interfaces,False,no_term_above_threshold +3770,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HTH-like nucleic-acid recognition motif,False,no_term_above_threshold +3771,36535,20.900524,0.9501953,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9448242,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9479750778816199,0.8193319549057253,0.004430660168365086,0.8,184.92322222222222,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Disordered N-terminal kinase tails,True,assigned_and_evaluated +3772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Groove-flanking β-strand/turn module,False,no_term_above_threshold +3773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic appendage activation,False,no_term_above_threshold +3774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-helicase primase region,False,no_term_above_threshold +3775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prepilin-like N-terminal signal-anchor,False,no_term_above_threshold +3776,64085,27.149858,0.7890625,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.78759766,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.5803931936166121,0.02733920574269397,0.012405848471422242,,2.2037352629021534,1.0,14.0,8.399690053536206,0.18163036575064237,Beta-propeller and alpha-solenoid scaffolds,True,assigned_and_evaluated +3777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp ATP-binding module,False,no_term_above_threshold +3778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycan/ECM-binding signal,False,no_term_above_threshold +3779,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane and N-terminal helices,False,no_term_above_threshold +3780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass cytosolic IDR tails,False,no_term_above_threshold +3781,58239,19.160368,0.7529297,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7529297,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7321831303563374,0.03939706370209239,0.017722640673460344,,2.222979319390563,1.0,8.0,4.481434155141311,0.3198233686329762,Noncatalytic alpha-helical scaffolds,True,assigned_and_evaluated +3782,85664,25.77743,0.8925781,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.8925781,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,10.0,18.0,184.01543209876544,5.582305698870992e-21,Leloir glycosyltransferase catalytic cores,True,assigned_too_few_test_positives +3783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Divalent metal binding catalytic loops,False,no_term_above_threshold +3784,64058,19.000341,0.67285156,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6689453,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8540538819183493,0.5811167291260968,0.006202924235711121,0.6428571428571429,93.68431840268575,17.0,17.0,113.99808795411089,4.31985177778818e-35,Rossmann-like dehydrogenase catalytic subdomain,True,assigned_and_evaluated +3785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemotaxis receptor coiled-coils,False,no_term_above_threshold +3786,85649,26.446972,0.96728516,Vaccinia Virus protein VP39,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7758789,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9709236697676229,0.649232396735851,0.0101905183872397,0.6086956521739131,63.70945736664415,16.0,16.0,110.61410018552876,7.117153535323136e-33,Class I SAM MTase motif,True,assigned_and_evaluated +3787,88163,19.307503,0.6508789,Transposable element,keyword,88163,Transposable element,0.6508789,122,keywords,Transposable element,keyword:keywords:Transposable element,11.0,2257.0,0.7661903990933377,0.3039314710860378,0.004873726185201595,0.45454545454545453,62.36121184010794,2.0,17.0,30.364654952890245,0.0034012828812999196,DDE transposase catalytic core activation,True,assigned_and_evaluated +3788,87586,20.807074,0.75927734,Host membrane,keyword,88161,Transmembrane helix,0.73095703,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7954589724859995,0.09283358683723276,0.01639344262295082,,5.662848797071199,1.0,18.0,3.5885999759239193,0.3849937413097085,Hydrophobic single-pass transmembrane helix,True,assigned_and_evaluated +3789,63831,18.092667,0.6567383,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.6567383,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.49600177698800535,0.002658396101019052,0.002658396101019052,,1.0,0.0,20.0,0.0,1.0,TonB-dependent receptor beta-barrel,True,assigned_and_evaluated +3790,37894,18.775297,1.0,Short-chain dehydrogenase/reductase SDR,interpro,85656,alpha/beta hydrolase,0.86279297,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR Rossmann cofactor-pocket hydrophobics,True,assigned_too_few_test_positives +3791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity mature effector peptides,False,no_term_above_threshold +3792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-centered β-strand initiation motif,False,no_term_above_threshold +3793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich nucleotide-binding loops,False,no_term_above_threshold +3794,36914,22.072763,0.9892578,Glycosyltransferase 2-like,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9614258,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,7.0,0.0,1.0,SDR Rossmann cofactor-binding helix,True,assigned_too_few_test_positives +3795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signals and viral motifs,False,no_term_above_threshold +3796,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Replication protein interaction motifs,False,no_term_above_threshold +3797,45714,17.057081,0.98046875,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.98046875,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,5.0,14.0,106.46607142857144,1.6256903696206572e-09,Disordered TF transactivation tails,True,assigned_too_few_test_positives +3798,37020,18.81804,0.94140625,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.7919922,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic helical sensory relays,True,assigned_too_few_test_positives +3799,52236,18.896696,0.98828125,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98583984,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,13.0,18.0,161.2719517270079,5.9181446936745386e-27,Alpha-solenoid repeat linker turns,True,assigned_too_few_test_positives +3800,31094,15.931841,0.94628906,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8066406,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.7982643524699601,0.38320083549591744,0.004430660168365086,0.6,86.48842857142857,0.0,12.0,0.0,1.0,Obg N-terminal domain,True,assigned_and_evaluated +3801,48255,17.095314,0.74658203,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.74658203,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,18.0,18.0,340.69142857142856,2.558082930606347e-45,Adenylation/PP-loop/NTase cores,True,assigned_too_few_test_positives +3802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GTPase G4-G5 helical hotspot,False,no_term_above_threshold +3803,63951,22.611103,0.9916992,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.8925781,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9993574535389482,0.8001914751914752,0.003987594151528578,1.0,200.67023994523996,17.0,17.0,161.13783783783785,1.3433661058868306e-37,Extracellular Ig-like domain signature,True,assigned_and_evaluated +3804,37894,16.128122,0.8925781,Short-chain dehydrogenase/reductase SDR,interpro,85712,3.40.630.30,0.80029297,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,12.0,0.0,1.0,ATPase active site switch loops,True,assigned_too_few_test_positives +3805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PYLKN nucleotidyltransferase β-strand motif,False,no_term_above_threshold +3806,37640,21.160994,0.94921875,EF-hand domain,interpro,46081,EF-hand domain pair,0.90625,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,14.0,0.0,1.0,ABC NBD glycine hotspots,True,assigned_too_few_test_positives +3807,49236,16.381199,0.9663086,C-type lectin fold,interpro,49236,C-type lectin fold,0.9663086,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.999822380106572,0.9428571428571428,0.002215330084182543,1.0,425.6057142857143,13.0,13.0,542.0090909090909,7.54613259578455e-36,Signal peptide and stalk,True,assigned_and_evaluated +3808,37341,22.290674,0.99853516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9902344,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.999983391463212,0.9986772486772486,0.011962782454585734,1.0,83.48202038016852,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD-propeller blade-tip surfaces,True,assigned_and_evaluated +3809,36449,17.189123,0.97509766,EamA domain,interpro,45290,Protein kinase-like domain superfamily,0.97021484,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,13.0,0.0,1.0,Protein kinase catalytic core,True,assigned_too_few_test_positives +3810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal targeting regions,False,no_term_above_threshold +3811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and TM helices,False,no_term_above_threshold +3812,35372,21.361786,0.9584961,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9584961,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,16.0,17.0,660.1633217993079,2.0308627383694374e-44,ABC TMD helix-loop junctions,True,assigned_too_few_test_positives +3813,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine/threonine-rich IDRs,False,no_term_above_threshold +3814,36104,15.665943,0.8857422,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8857422,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Extracellular acidic-Glycine motif,True,assigned_too_few_test_positives +3815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-sandwich edge strand,False,no_term_above_threshold +3816,55053,19.787066,0.8833008,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.8833008,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,18.0,0.0,1.0,Noncatalytic surface interaction patch,True,assigned_too_few_test_positives +3817,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rieske-type oxygenase alpha subunits,False,no_term_above_threshold +3818,25361,16.111883,0.83691406,mediator complex,go_cc,8103,regulation of transcription by RNA polymerase II,0.67285156,67,go,GO:0016592,go_cc:go:GO:0016592,,,,,,,,5.0,16.0,97.54744764397905,2.7854571482640253e-09,Polar low-complexity nuclear IDRs,True,assigned_too_few_test_positives +3819,37894,21.953321,0.8256836,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8256836,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Soluble ligand/metal-binding pockets,True,assigned_too_few_test_positives +3820,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered kinks and turns,False,no_term_above_threshold +3821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible PRPP-binding loops,False,no_term_above_threshold +3822,59229,15.57723,0.8027344,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.796875,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9010645751430463,0.09088731492333771,0.0101905183872397,,8.918811729651008,0.0,16.0,0.0,1.0,GxDG hydrophobic loop peaks,True,assigned_and_evaluated +3823,35372,16.66463,0.93359375,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.93359375,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,1.0,15.0,46.76156862745098,0.03562741787175889,Permease transmembrane helices,True,assigned_too_few_test_positives +3824,87855,15.978714,0.671875,Nucleotide-binding,keyword,87855,Nucleotide-binding,0.671875,784,keywords,Nucleotide-binding,keyword:keywords:Nucleotide-binding,80.0,2257.0,0.7820452457510335,0.08273150514649796,0.03544528134692069,,2.334062588945574,0.0,13.0,0.0,1.0,Transmembrane helices and catalytic residues,True,assigned_and_evaluated +3825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-to-C helix-strand core blocks,False,no_term_above_threshold +3826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA polymerase N-terminal cleft scaffold,False,no_term_above_threshold +3827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tails,False,no_term_above_threshold +3828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed low-hydrophobicity residues,False,no_term_above_threshold +3829,61392,23.822134,0.9995117,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.9995117,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9991111111111111,0.7191403834260977,0.0031014621178555605,1.0,231.87140648467178,19.0,20.0,159.10098314606742,6.619253608489168e-41,LRR repeat-boundary loops,True,assigned_and_evaluated +3830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Condensing enzyme substrate channel loop,False,no_term_above_threshold +3831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane helices,False,no_term_above_threshold +3832,36010,19.405375,0.984375,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9506836,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,15.0,0.0,1.0,Serine hydrolase upstream motif,True,assigned_too_few_test_positives +3833,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-linked glycan-donor TM helix,False,no_term_above_threshold +3834,88161,68.948,0.76464844,Transmembrane helix,keyword,88161,Transmembrane helix,0.76464844,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8033605724116359,0.6238959543039186,0.1847585290208241,0.6906474820143885,3.3768181507528645,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Lipid-facing transmembrane helix residues,True,assigned_and_evaluated +3835,61392,18.64405,0.89208984,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.89208984,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.8354285714285714,0.06423835827249719,0.0031014621178555605,,20.71228208871802,0.0,15.0,0.0,1.0,Beta-solenoid strand repeats,True,assigned_and_evaluated +3836,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured globular domain core,False,no_term_above_threshold +3837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-catalytic active-site linkers,False,no_term_above_threshold +3838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asparagine-rich low-complexity IDRs,False,no_term_above_threshold +3839,47529,16.647118,0.7504883,Immunoglobulin-like fold,interpro,88159,Transmembrane,0.6357422,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8175340249888443,0.10131504695345647,0.007089056269384138,,14.291753810871954,10.0,18.0,42.96080126819427,1.1419576217727897e-14,Ectodomain-TM helix junction,True,assigned_and_evaluated +3840,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compositionally biased terminal segments,False,no_term_above_threshold +3841,36535,19.513699,0.9458008,Protein kinase domain,interpro,64058,NAD(P)-binding domain superfamily,0.8886719,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9418113039608367,0.2781092577097978,0.004430660168365086,,62.769259465101364,0.0,10.0,0.0,1.0,Rossmann NAD(P)+ β→α loop,True,assigned_and_evaluated +3842,37894,29.26793,1.0,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.9609375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,13.0,709.7738095238095,2.0554498274794366e-37,SDR NAD(P)H-binding Rossmann loop,True,assigned_too_few_test_positives +3843,48880,16.861338,0.98095703,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.98095703,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,12.0,12.0,484.7235772357723,1.4964064692158004e-32,Fold-I PLP N-terminal helix,True,assigned_too_few_test_positives +3844,46929,29.573217,0.99658203,"Zinc finger, RING/FYVE/PHD-type",interpro,29166,zinc ion binding,0.78271484,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9994671403197158,0.6861904761904762,0.002215330084182543,1.0,309.746380952381,10.0,17.0,50.53483641295135,1.8250514702226833e-15,Cys/His-coordinated zinc fingers,True,assigned_and_evaluated +3845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic ligand-binding cavities,False,no_term_above_threshold +3846,58239,22.477468,0.78027344,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78027344,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8972936400541272,0.17525056610442097,0.017722640673460344,0.025,9.888513192441954,0.0,10.0,0.0,1.0,Hydrophobic beta-strand cores,True,assigned_and_evaluated +3847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-turn-strand catalytic core,False,no_term_above_threshold +3848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane–extracellular loop boundary,False,no_term_above_threshold +3849,36104,24.339615,0.95996094,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.95996094,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Auxiliary ligand-docking domains,True,assigned_too_few_test_positives +3850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central beta-strand glycine motif,False,no_term_above_threshold +3851,85762,29.963278,0.83203125,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.8276367,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,11.0,11.0,205.58965517241379,9.285739698946585e-26,Flavoprotein cap/lid activation,True,assigned_too_few_test_positives +3852,43624,17.19521,0.83154297,Homedomain-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8027344,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.9239876171352074,0.13121496528108204,0.007089056269384138,0.0625,18.509511039962636,0.0,14.0,0.0,1.0,Acidic Asp/Glu clusters,True,assigned_and_evaluated +3853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical nucleation segments,False,no_term_above_threshold +3854,46081,15.955944,0.9404297,EF-hand domain pair,interpro,46081,EF-hand domain pair,0.9404297,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.972960204535349,0.06406071280273928,0.003544528134692069,,18.07312859947282,0.0,17.0,0.0,1.0,Donor-binding hydrophobic micro-patch,True,assigned_and_evaluated +3855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-capping interface hinge,False,no_term_above_threshold +3856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate binding catalytic motifs,False,no_term_above_threshold +3857,37020,16.092775,0.9970703,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,19.0,730.7548666186012,2.5754498304135963e-47,Glycosyltransferase glycine-rich donor loop,True,assigned_too_few_test_positives +3858,87413,20.743868,0.6220703,Disulfide bond,keyword,87413,Disulfide bond,0.6220703,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6527077992869559,0.10864920135017682,0.0717766947275144,0.006172839506172839,1.513711403995982,9.0,17.0,6.261467729325414,5.385349873681651e-06,C-terminal Pro/Gly-Asp motif,True,assigned_and_evaluated +3859,36104,20.813461,0.98535156,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.98535156,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Beta-sandwich ectodomain scaffolds,True,assigned_too_few_test_positives +3860,61392,15.872892,0.9658203,Leucine-rich repeat domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7861328,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9737460317460317,0.1923154629803327,0.0031014621178555605,0.14285714285714285,62.00799999237299,2.0,19.0,17.628917800118273,0.009768421547433688,GH5 TIM-barrel stabilizing residues,True,assigned_and_evaluated +3861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad helical and disordered activation,False,no_term_above_threshold +3862,37894,19.899658,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.79248047,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR Rossmann core helix,True,assigned_too_few_test_positives +3863,39971,23.049898,0.9819336,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.95751953,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,15.0,17.0,584.5196078431372,1.741555167543374e-40,Metallophosphoesterase interdomain linker,True,assigned_too_few_test_positives +3864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligase/GTase NTase catalytic cores,False,no_term_above_threshold +3865,87276,27.06061,0.60498047,Cell membrane,keyword,87276,Cell membrane,0.60498047,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6175527203250806,0.31082967410561196,0.11120957022596367,0.2549800796812749,2.7949903364795468,17.0,19.0,7.341743086038797,8.654145245761993e-14,Multipass transmembrane helix signal,True,assigned_and_evaluated +3866,37894,20.557692,0.8022461,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.70996094,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,14.0,0.0,1.0,SDR Rossmann NAD-binding domain,True,assigned_too_few_test_positives +3867,45324,17.041216,0.9970703,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.91064453,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,5.0,15.0,182.32721712538225,1.1652002528024084e-10,Repeat-start/strand-capping segments,True,assigned_and_evaluated +3868,87882,17.799238,0.7680664,Palmitate,keyword,88058,Signal,0.68896484,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9510587886865096,0.11086561712084529,0.002658396101019052,0.16666666666666666,41.7039496402913,2.0,12.0,11.102607076350091,0.02282730335792513,Mature extracytoplasmic active-site loops,True,assigned_and_evaluated +3869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory ectodomains and adaptor appendages,False,no_term_above_threshold +3870,38873,19.61508,0.9501953,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.93359375,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9849023090586145,0.07780540464466894,0.002215330084182543,,35.12135965660356,8.0,16.0,85.66235632183908,3.531292860339808e-14,Post-P-loop β2 pocket segment,True,assigned_and_evaluated +3871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane interaction modules,False,no_term_above_threshold +3872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered extracytoplasmic N-terminal assembly segments,False,no_term_above_threshold +3873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic helix-loop caps,False,no_term_above_threshold +3874,84753,29.69324,0.83496094,3.30.420.40,gene3d,84753,3.30.420.40,0.83496094,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,16.0,16.0,414.03472222222223,6.262334472469416e-42,Conserved Hsp70 chaperone core,True,assigned_too_few_test_positives +3875,81858,19.101616,0.9692383,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6816406,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Non-cytosolic loop-helix junctions,True,assigned_too_few_test_positives +3876,36115,16.102364,0.69140625,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.6879883,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,7.0,17.0,152.48337595907927,4.004963657130345e-14,Recognition domain and motif reader,True,assigned_too_few_test_positives +3877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent loops and helices,False,no_term_above_threshold +3878,72011,18.193289,0.9082031,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9082031,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,N-terminal pre-catalytic beta-hairpin,True,assigned_too_few_test_positives +3879,55053,17.639257,0.9848633,Chloramphenicol acetyltransferase-like domain superfamily,interpro,69093,"ANL, N-terminal domain",0.9267578,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,10.0,10.0,552.0462962962963,8.365098670586762e-28,Carboxylate activation and transfer,True,assigned_too_few_test_positives +3880,36449,16.085796,0.9838867,EamA domain,interpro,36449,EamA domain,0.9838867,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,7.0,17.0,438.3897058823529,2.066015069679448e-17,Membrane interface helix linkers/caps,True,assigned_too_few_test_positives +3881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-assisted nuclease/phosphotransfer signature,False,no_term_above_threshold +3882,37341,23.143219,0.9970703,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99365234,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9986879255937552,0.8802458476416588,0.011962782454585734,1.0,73.58203252323051,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 blade C-terminal beta-strand,True,assigned_and_evaluated +3883,85649,20.709753,0.73583984,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.73095703,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7742205441594332,0.24345672547042282,0.0101905183872397,0.391304347826087,23.890514321162794,0.0,18.0,0.0,1.0,PAS/HAMP sensory interface helices,True,assigned_and_evaluated +3884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured core scaffold detector,False,no_term_above_threshold +3885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil scaffolds with regulatory tails,False,no_term_above_threshold +3886,87326,41.317738,0.81884766,Coiled coil,keyword,87326,Coiled coil,0.81884766,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8451713379493345,0.31445414726154425,0.03943287549844927,0.33707865168539325,7.974415846846128,10.0,16.0,7.8797050116303655,9.899978222928872e-08,Coiled-coil heptad interface,True,assigned_and_evaluated +3887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-binding core activation,False,no_term_above_threshold +3888,47529,20.989017,0.9584961,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9584961,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9765032351628737,0.43014789444534834,0.007089056269384138,0.3125,60.67773736019695,15.0,18.0,64.4412019022914,1.0108141398209011e-25,Beta-sandwich strand detector,True,assigned_and_evaluated +3889,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short C-terminal helix hotspot,False,no_term_above_threshold +3890,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretome and extracellular-like signature,False,no_term_above_threshold +3891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-adjacent core helix,False,no_term_above_threshold +3892,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-termini and coiled coils,False,no_term_above_threshold +3893,88009,26.449404,0.6503906,Repeat,keyword,88009,Repeat,0.6503906,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7707952175078367,0.2920505037528698,0.07266282676118742,0.18292682926829268,4.0192560181111405,8.0,9.0,7.8805121850475,4.135889505569974e-07,EF-hand flanking charged helices,True,assigned_and_evaluated +3894,48880,20.53973,0.99560547,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.99560547,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,PLP enzyme N-terminal helix-loop,True,assigned_too_few_test_positives +3895,88022,16.552181,0.78466797,Ribosomal protein,keyword,88022,Ribosomal protein,0.78466797,279,keywords,Ribosomal protein,keyword:keywords:Ribosomal protein,50.0,2257.0,0.8291662890801994,0.09412980365070367,0.022153300841825433,,4.249019336792763,0.0,15.0,0.0,1.0,Secondary-structure junction signal,True,assigned_and_evaluated +3896,85364,17.04215,0.6904297,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.6904297,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,16.0,20.0,240.89292929292932,3.186284787002184e-36,C-terminal structural segment detector,True,assigned_too_few_test_positives +3897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical coiled-coil/IDR signature,False,no_term_above_threshold +3898,64003,18.993698,0.859375,Zinc finger C2H2 superfamily,interpro,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.8027344,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.8792012653222618,0.4283823588348958,0.003987594151528578,0.4444444444444444,107.42877598781776,15.0,15.0,130.4617067833698,6.27862990657517e-32,Disordered TF regulatory tails,True,assigned_and_evaluated +3899,36091,19.44864,0.80810547,GNAT domain,interpro,36091,GNAT domain,0.80810547,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,ABC NBD pre-Walker A beta-strand,True,assigned_too_few_test_positives +3900,64507,28.539616,0.99609375,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99609375,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat helix-2 register,True,assigned_and_evaluated +3901,72011,17.024893,0.9633789,"AMP-binding enzyme, C-terminal domain superfamily",interpro,48241,RmlC-like jelly roll fold,0.84521484,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,ABC/HK ATP-binding motifs,True,assigned_too_few_test_positives +3902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Haloarchaeal acidic low-complexity secretome,False,no_term_above_threshold +3903,72011,16.687992,0.98876953,"AMP-binding enzyme, C-terminal domain superfamily",interpro,64058,NAD(P)-binding domain superfamily,0.7319336,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,1.0,9.0,65.58965896589659,0.025632360289712507,SDR active-site gating loop,True,assigned_too_few_test_positives +3904,47529,20.558895,0.94873047,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.94873047,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9557675145024542,0.11035586708691157,0.007089056269384138,,15.567074500947465,6.0,18.0,25.77648076091656,1.4717267288515366e-07,Beta-strand residue signal,True,assigned_and_evaluated +3905,88160,16.468887,0.875,Transmembrane beta strand,keyword,25167,cell outer membrane,0.70166016,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,14.0,18.0,225.10625674217906,2.719861911906338e-31,Lipid-exposed outer-membrane beta-barrel residues,True,assigned_too_few_test_positives +3906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich low-complexity IDRs,False,no_term_above_threshold +3907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic basic juxtamembrane loop,False,no_term_above_threshold +3908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored surface loop motifs,False,no_term_above_threshold +3909,45324,18.839104,0.87597656,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.87597656,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9952042628774422,0.21972943722943722,0.002215330084182543,,99.18586796536796,0.0,16.0,0.0,1.0,TBCC/Cofactor-C beta-strand hotspot,True,assigned_and_evaluated +3910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interface helices,False,no_term_above_threshold +3911,61392,22.163757,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.64941406,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,167.4747191011236,3.9106228067767924e-42,LRR loop register detector,True,assigned_and_evaluated +3912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad whole-protein activation,False,no_term_above_threshold +3913,45551,16.122366,0.91308594,SKP1/BTB/POZ domain superfamily,interpro,87697,Knottin,0.8017578,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,14.0,0.0,1.0,Domain surfaces around active sites,True,assigned_too_few_test_positives +3914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical face exposure sensor,False,no_term_above_threshold +3915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured amphipathic interface regions,False,no_term_above_threshold +3916,87873,17.156487,0.6723633,Oxidoreductase,keyword,87601,Hydrolase,0.6274414,537,keywords,Oxidoreductase,keyword:keywords:Oxidoreductase,48.0,2257.0,0.666544062169911,0.0666398309295487,0.021267168808152416,,3.133460383499821,1.0,18.0,1.3969961104081727,0.8037255970015798,Formimidoylglutamase DEG acidic loop,True,assigned_and_evaluated +3917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +3918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic catalytic surface loops,False,no_term_above_threshold +3919,49116,16.510096,0.7910156,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.7910156,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8918738898756661,0.1225738528501405,0.002215330084182543,,55.329837176553426,2.0,20.0,8.703795620437957,0.03670159417435684,Large non-enzymatic scaffold subunits,True,assigned_and_evaluated +3920,85364,22.306051,0.82470703,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.82470703,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,Acidic metal and carboxylate clefts,True,assigned_too_few_test_positives +3921,48883,19.546618,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,10.0,10.0,480.8145161290322,3.427950356257294e-27,AAT-like PLP C-terminal region,True,assigned_too_few_test_positives +3922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp N-terminal pre-domain,False,no_term_above_threshold +3923,85656,17.340088,0.9291992,alpha/beta hydrolase,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.90478516,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9845396825396825,0.156041110043303,0.0031014621178555605,,50.3121121953907,0.0,17.0,0.0,1.0,Active-site β–α junctions,True,assigned_and_evaluated +3924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic aromatic N-terminal motif,False,no_term_above_threshold +3925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VFT/Cache ligand-binding domains,False,no_term_above_threshold +3926,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intrinsic disorder/low-complexity detector,False,no_term_above_threshold +3927,46932,21.471403,0.7817383,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.7817383,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.8961726746773476,0.6952917264392674,0.004430660168365086,0.7,156.92734265734265,19.0,19.0,108.20508166969147,1.1793478982521608e-38,Disordered low-complexity ZNF regions,True,assigned_and_evaluated +3928,88152,17.73209,0.69677734,Transducer,keyword,88152,Transducer,0.69677734,76,keywords,Transducer,keyword:keywords:Transducer,,,,,,,,3.0,16.0,29.26423429319372,0.00024958564359450227,Cytosolic juxtamembrane amphipathic helix,True,assigned_too_few_test_positives +3929,88160,18.027193,0.8046875,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6723633,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,18.0,19.0,274.18957588145116,5.9579855910490204e-43,Outer-membrane β-barrel porins,True,assigned_too_few_test_positives +3930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Large globular catalytic cores,False,no_term_above_threshold +3931,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping segment,False,no_term_above_threshold +3932,50338,16.433784,0.9609375,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.68408203,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane helix packing interfaces,True,assigned_too_few_test_positives +3933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal nucleotide-binding catalytic subdomains,False,no_term_above_threshold +3934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-junction allosteric interfaces,False,no_term_above_threshold +3935,87277,19.927805,0.8256836,Cell outer membrane,keyword,88058,Signal,0.7573242,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.9766031746031746,0.2449311006453864,0.0031014621178555605,,78.97278487951958,4.0,20.0,29.2977886977887,1.77668342032528e-05,Sec-dependent signal peptide,True,assigned_and_evaluated +3936,82107,21.311304,0.84375,1.20.1280.50,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.76220703,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,13.0,0.0,1.0,GTPase G5-helix activation,True,assigned_too_few_test_positives +3937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helices of Xaa-Pro DPPs,False,no_term_above_threshold +3938,36776,18.166845,0.97998047,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.9770508,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9853028283725752,0.0906734389691526,0.002658396101019052,,34.108325292229566,0.0,17.0,0.0,1.0,Short nucleic-acid contact patches,True,assigned_and_evaluated +3939,88009,21.479948,0.6064453,Repeat,keyword,88009,Repeat,0.6064453,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.5874386747928635,0.11240583230253612,0.07266282676118742,0.012195121951219513,1.5469509969928295,15.0,15.0,8.865576208178439,1.3902955836363565e-14,Glycine polar repeat hotspots,True,assigned_and_evaluated +3940,49045,15.957723,0.98291016,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96728516,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,19.0,0.0,1.0,Blade/rung coil-β boundaries,True,assigned_too_few_test_positives +3941,37894,17.967964,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.9067383,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR catalytic Ser loop-helix,True,assigned_too_few_test_positives +3942,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary microsegments,False,no_term_above_threshold +3943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal binding interface,False,no_term_above_threshold +3944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PagP LPS-recognition motif,False,no_term_above_threshold +3945,81858,15.747217,0.95654297,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7426758,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane helix cores,True,assigned_too_few_test_positives +3946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic binding interface regions,False,no_term_above_threshold +3947,38873,18.328129,0.87158203,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.83935547,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7891651865008881,0.059219465367006355,0.002215330084182543,,26.73166666666667,2.0,19.0,18.034180278281912,0.009351777039257061,Switch-II/Walker-B catalytic segment,True,assigned_and_evaluated +3948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered motif-flanking and repeat linkers,False,no_term_above_threshold +3949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GTPase/Lipid Interfaces with Regulatory IDRs,False,no_term_above_threshold +3950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal loop-helix cap,False,no_term_above_threshold +3951,64599,22.748064,0.98046875,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.98046875,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,16.0,18.0,588.8493827160494,4.036993795200243e-43,J-domain/DnaJC and polyomavirus T-antigens,True,assigned_too_few_test_positives +3952,38873,18.506748,0.98291016,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9370117,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9980461811722914,0.49795482295482296,0.002215330084182543,0.2,224.7768070818071,15.0,15.0,171.32471264367817,1.0841831409947753e-33,Walker B catalytic glutamate,True,assigned_and_evaluated +3953,87326,27.640924,0.60839844,Coiled coil,keyword,87326,Coiled coil,0.60839844,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6504389692773334,0.16496837978474801,0.03943287549844927,0.056179775280898875,4.183523968249172,9.0,17.0,6.674573656910428,3.1772786071036616e-06,Coiled-coil scaffolding helices,True,assigned_and_evaluated +3954,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early N-terminal beta-strand ligand-binding segment,False,no_term_above_threshold +3955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regulatory tails,False,no_term_above_threshold +3956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity transition segments,False,no_term_above_threshold +3957,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribosyltransferase catalytic core,False,no_term_above_threshold +3958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal IDRs and boundary helices,False,no_term_above_threshold +3959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enolate-dependent C–C lyases,False,no_term_above_threshold +3960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycine sugar binding patch,False,no_term_above_threshold +3961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme glycan-binding loop signature,False,no_term_above_threshold +3962,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich stalks and linkers,False,no_term_above_threshold +3963,25169,20.717997,0.82958984,pilus,go_cc,25169,pilus,0.82958984,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9962699822380106,0.24993464052287578,0.002215330084182543,,112.82049673202614,2.0,16.0,69.00578703703704,0.0006847995830421913,Extracellular C-terminal stalk/anchor,True,assigned_and_evaluated +3964,36104,16.440582,0.8666992,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8666992,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Conserved PRA-PH catalytic motif,True,assigned_too_few_test_positives +3965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SWI2/SNF2 C-terminal accessory region,False,no_term_above_threshold +3966,36977,16.040619,0.96240234,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8432617,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,18.0,0.0,1.0,Two-component coiled-coil heptad register,True,assigned_too_few_test_positives +3967,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass cytosolic C-terminal regulatory tails,False,no_term_above_threshold +3968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sestrin-related oxidoreductases and dehalogenases,False,no_term_above_threshold +3969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal ectodomains and cytosolic cores,False,no_term_above_threshold +3970,87413,19.709995,0.64746094,Disulfide bond,keyword,87413,Disulfide bond,0.64746094,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5534650402192168,0.07824773410827437,0.0717766947275144,,1.0901551597677486,1.0,15.0,0.7884811214706077,1.0,TAFA conserved residue motifs,True,assigned_and_evaluated +3971,85712,22.881767,0.83935547,3.40.630.30,gene3d,85712,3.40.630.30,0.83935547,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,14.0,17.0,233.80784313725488,8.270985853984719e-32,Active-site flanking loop,True,assigned_too_few_test_positives +3972,8200,20.713594,0.68896484,proteolysis,go_bp,8200,proteolysis,0.68896484,331,go,GO:0006508,go_bp:go:GO:0006508,24.0,2257.0,0.7657859381997314,0.273581338580671,0.010633584404076208,0.3333333333333333,25.728045049023937,11.0,13.0,40.78297369566569,5.364996791081551e-17,Chymotrypsin-fold catalytic signature,True,assigned_and_evaluated +3973,87413,19.487732,0.6357422,Disulfide bond,keyword,87413,Disulfide bond,0.6357422,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5829296679336455,0.08211598974529385,0.0717766947275144,,1.1440480793526435,1.0,17.0,0.6957186365917126,1.0,Active-site micro-motif clusters,True,assigned_and_evaluated +3974,36499,17.17794,0.94873047,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.94873047,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,16.0,0.0,1.0,Multipass disordered terminal tails,True,assigned_too_few_test_positives +3975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic CBS/C-linker regulators,False,no_term_above_threshold +3976,87390,15.730228,0.70947266,Defensin,keyword,87390,Defensin,0.70947266,37,keywords,Defensin,keyword:keywords:Defensin,,,,,,,,0.0,18.0,0.0,1.0,GOLD domains and acidic linkers,True,assigned_too_few_test_positives +3977,37446,28.162748,0.92529297,F-box domain,interpro,63831,F-box-like domain superfamily,0.92333984,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9946031746031746,0.3764130434782609,0.0031014621178555605,0.2857142857142857,121.3663198757764,17.0,20.0,197.96035156249997,2.368875867757361e-37,LRR beta-strand core,True,assigned_and_evaluated +3978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal targeting signals,False,no_term_above_threshold +3979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet hydrophobic packing,False,no_term_above_threshold +3980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor and catalytic helices,False,no_term_above_threshold +3981,87149,20.994719,0.6777344,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6777344,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7422290585143883,0.1815511670188366,0.012405848471422242,0.32142857142857145,14.634320855768365,0.0,19.0,0.0,1.0,Helical scaffolds and targeting regions,True,assigned_and_evaluated +3982,85675,18.269762,0.9506836,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9277344,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,17.0,18.0,516.5937818552497,3.251667628033392e-45,VWA beta-strand-loop motifs,True,assigned_too_few_test_positives +3983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short conserved binding-site motifs,False,no_term_above_threshold +3984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP PP-binding GDG-loop module,False,no_term_above_threshold +3985,45290,18.090195,0.7133789,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7133789,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.8038872891814068,0.42933265720150965,0.0057598582188746125,0.38461538461538464,74.53875440798517,12.0,12.0,73.42487684729065,1.0507091557588485e-22,Plant RLK disordered C-terminal tail,True,assigned_and_evaluated +3986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundary sensor,False,no_term_above_threshold +3987,10369,18.631056,0.7128906,DNA integration,go_bp,10369,DNA integration,0.7128906,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,11.0,14.0,429.7712975098296,5.579168795236492e-28,LTR retroelement integrase module,True,assigned_too_few_test_positives +3988,36115,24.998804,0.9995117,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9995117,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,17.0,18.0,349.74361628709454,1.9305630148203288e-42,BTB N-terminal boundary linker,True,assigned_too_few_test_positives +3989,84152,17.632622,0.9741211,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9741211,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,17.0,0.0,1.0,Central-metabolism active-site loops,True,assigned_too_few_test_positives +3990,36104,25.404657,0.9160156,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9160156,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Structured hydrophobic assembly cores,True,assigned_too_few_test_positives +3991,48880,21.34395,0.98095703,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.98095703,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,14.0,14.0,484.7235772357723,7.836327138722209e-38,AAT-fold PLP-binding core,True,assigned_too_few_test_positives +3992,36876,16.082752,0.91845703,Cytochrome P450,interpro,36876,Cytochrome P450,0.91845703,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9439007512850929,0.8893319549057255,0.003987594151528578,0.8888888888888888,223.0246913580247,0.0,13.0,0.0,1.0,Pre-motif helical scaffold,True,assigned_and_evaluated +3993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved alpha-helical interaction surfaces,False,no_term_above_threshold +3994,45290,27.941902,0.97216797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97216797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.997977512683395,0.9153778618221111,0.0057598582188746125,0.9230769230769231,158.9236795486542,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase N-lobe β-strand hydrophobics,True,assigned_and_evaluated +3995,59237,18.891966,0.9951172,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.9951172,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,11.0,18.0,191.7634502923977,2.2933673724323075e-23,Ubiquitin-like domain detector,True,assigned_too_few_test_positives +3996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich disordered regulatory segments,False,no_term_above_threshold +3997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical readers and disordered tails,False,no_term_above_threshold +3998,85664,23.76741,0.96972656,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.96972656,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase YLSR capping helix,True,assigned_too_few_test_positives +3999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed membrane-proximal tails,False,no_term_above_threshold +4000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil helices,False,no_term_above_threshold +4001,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated N-terminal IDRs,False,no_term_above_threshold +4002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity termini/linkers,False,no_term_above_threshold +4003,36499,19.687124,0.97021484,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.97021484,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,19.0,0.0,1.0,Disordered low-complexity regulatory tails,True,assigned_too_few_test_positives +4004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic C-terminus detector,False,no_term_above_threshold +4005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/PAC beta-strand core,False,no_term_above_threshold +4006,43583,17.250679,0.93310547,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.93310547,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,12.0,13.0,384.8585260892953,1.1449263824167685e-30,Serine protease C-terminal cap/linker,True,assigned_and_evaluated +4007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory C-terminal cap or tail,False,no_term_above_threshold +4008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cationic amphipathic patches,False,no_term_above_threshold +4009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-centered bacterial enzyme inserts,False,no_term_above_threshold +4010,64146,20.442148,0.85009766,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.85009766,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.9059972209815891,0.043036244195489216,0.007975188303057155,,5.396266841623287,0.0,15.0,0.0,1.0,GDP-mannose dehydratase helical motifs,True,assigned_and_evaluated +4011,61392,20.600788,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.67333984,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,14.0,14.0,167.4747191011236,2.3187224721210777e-31,LRR post-beta-strand loop,True,assigned_and_evaluated +4012,87857,22.566692,0.6816406,Nucleus,keyword,87857,Nucleus,0.6816406,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7900846639584925,0.18564143877219633,0.06247230837394772,,2.97157962630388,5.0,19.0,1.5944854514334617,0.3054783743763554,Proline-directed IDR phosphorylation,True,assigned_and_evaluated +4013,87991,15.657016,0.7939453,Pyrrolidone carboxylic acid,keyword,87991,Pyrrolidone carboxylic acid,0.7939453,223,keywords,Pyrrolidone carboxylic acid,keyword:keywords:Pyrrolidone carboxylic acid,11.0,2257.0,0.7437464583501985,0.013800064764453205,0.004873726185201595,,2.831522379397353,0.0,19.0,0.0,1.0,Low-complexity N-terminal activation modules,True,assigned_and_evaluated +4014,47717,17.135042,0.99853516,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7055664,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,11.0,248.62802335279397,1.1046647748237842e-23,Helicase ATPase core motifs,True,assigned_too_few_test_positives +4015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding lid motif,False,no_term_above_threshold +4016,49116,23.663326,0.984375,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.984375,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.999822380106572,0.9266666666666665,0.002215330084182543,1.0,418.2973333333333,19.0,20.0,82.68605839416058,1.163776261464173e-35,HEAT/ARM and coiled-coil scaffolds,True,assigned_and_evaluated +4017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short-helix cap/hinge repeats,False,no_term_above_threshold +4018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter pore-lining helices,False,no_term_above_threshold +4019,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal coiled-coil interaction modules,False,no_term_above_threshold +4020,59224,23.363262,0.9814453,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8486328,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9982857142857142,0.5235499462943072,0.0031014621178555605,0.8571428571428571,168.80746125517877,0.0,16.0,0.0,1.0,Amphipathic active-site lid helix,True,assigned_and_evaluated +4021,87413,20.899515,0.6015625,Disulfide bond,keyword,87413,Disulfide bond,0.6015625,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6445092666254162,0.13018534629215572,0.0717766947275144,,1.813755102354293,2.0,19.0,1.2449701917956963,0.7551009893139149,Extracellular glycan recognition modules,True,assigned_and_evaluated +4022,25169,17.619165,0.74560547,pilus,go_cc,25169,pilus,0.74560547,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8914298401420959,0.12069396207418416,0.002215330084182543,,54.48125448028674,0.0,19.0,0.0,1.0,Phage tail-related structural proteins,True,assigned_and_evaluated +4023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenosine cofactor-binding subdomains,False,no_term_above_threshold +4024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short gly/acidic helix-cap motifs,False,no_term_above_threshold +4025,87697,25.03156,0.83691406,Knottin,keyword,87697,Knottin,0.83691406,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.949694804744399,0.4025173419611272,0.017279574656623838,0.6153846153846154,23.294401046314462,0.0,19.0,0.0,1.0,Extracellular Cys–Trp disulfide-loop motif,True,assigned_and_evaluated +4026,82608,40.062073,0.9951172,Ankyrin repeat-containing domain,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.9946289,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.9999444197421076,0.9861111111111112,0.003544528134692069,1.0,278.20659722222223,17.0,17.0,170.34571428571428,5.351432831165409e-38,Ankyrin repeat AB-loop turns,True,assigned_and_evaluated +4027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory extension,False,no_term_above_threshold +4028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Crotonase CoA-binding hairpin,False,no_term_above_threshold +4029,28025,15.92387,0.8466797,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.7026367,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9119650525692286,0.3092393623131328,0.002658396101019052,0.8333333333333334,116.32554012345679,3.0,16.0,50.81335227272727,4.955973182359977e-05,GTPase G4 guanine-specificity helix,True,assigned_and_evaluated +4030,85675,21.78234,0.9033203,"von Willebrand factor, type A domain",gene3d,50806,"Homeobox, conserved site",0.84716797,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,14.0,16.0,478.60894495412845,1.374908525618535e-36,VWA adhesins and Sec23 loops,True,assigned_too_few_test_positives +4031,50806,19.563435,0.9033203,"Homeobox, conserved site",interpro,37071,Homeodomain,0.8798828,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,PIPK activation loop hotspot,True,assigned_too_few_test_positives +4032,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic helical MoRF,False,no_term_above_threshold +4033,85364,22.62444,0.8359375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8359375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,PBP/SBP hinge-lid gating segment,True,assigned_too_few_test_positives +4034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding active-site core,False,no_term_above_threshold +4035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic and regulatory tails,False,no_term_above_threshold +4036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isolated residue hotspots,False,no_term_above_threshold +4037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease TM GxxxG motif,False,no_term_above_threshold +4038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent phosphodiesterase core,False,no_term_above_threshold +4039,64620,21.122688,1.0,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,1.0,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,14.0,19.0,238.75686498855833,2.0222494467957904e-31,ATP-binding N-box helix,True,assigned_too_few_test_positives +4040,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed acidic beta-sheet faces,False,no_term_above_threshold +4041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic glycan-binding domains,False,no_term_above_threshold +4042,45804,17.54317,0.9472656,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.67822266,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,18.0,0.0,1.0,Interface/gating transmembrane helix,True,assigned_too_few_test_positives +4043,84991,18.279099,1.0,3.30.70.20,gene3d,84991,3.30.70.20,1.0,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,4.0,6.0,462.17829457364337,1.2760811649223317e-10,Ferredoxin flanking helices,True,assigned_too_few_test_positives +4044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-strand hydrophobic residues,False,no_term_above_threshold +4045,4066,21.700855,0.96191406,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.96191406,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.8917850799289521,0.564988520562291,0.002215330084182543,0.6,255.03581818181817,9.0,18.0,359.16265060240966,1.6320574865634491e-21,PD-(D/E)XK nuclease activation signature,True,assigned_and_evaluated +4046,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase ATPase C-terminal helical lobe,False,no_term_above_threshold +4047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active site pocket walls,False,no_term_above_threshold +4048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interior catalytic cofactor cores,False,no_term_above_threshold +4049,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polynucleotide ligase NTase core,False,no_term_above_threshold +4050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exported protein mature-domain core,False,no_term_above_threshold +4051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protease scaffold signal,False,no_term_above_threshold +4052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Broad activation, C-terminal capping hotspot",False,no_term_above_threshold +4053,25169,18.566061,0.9116211,pilus,go_cc,47529,Immunoglobulin-like fold,0.8857422,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.969538188277087,0.039504099635507814,0.002215330084182543,,17.83215057546823,0.0,15.0,0.0,1.0,Tyrosine-centered beta-strand motif,True,assigned_and_evaluated +4054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminal activation elements,False,no_term_above_threshold +4055,28962,15.99804,0.68603516,oxygen carrier activity,go_mf,28962,oxygen carrier activity,0.68603516,51,go,GO:0005344,go_mf:go:GO:0005344,,,,,,,,12.0,16.0,538.7439759036145,1.7308953236192073e-31,Heme-based O2/NO sensor domains,True,assigned_too_few_test_positives +4056,38317,20.347939,0.9321289,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9321289,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7818412698412699,0.01250479123924449,0.0031014621178555605,,4.031901975282116,0.0,19.0,0.0,1.0,Alpha-helix C-cap turns,True,assigned_and_evaluated +4057,36914,24.83374,0.9921875,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.9921875,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,19.0,0.0,1.0,Histidine kinase CA ATP-binding site,True,assigned_too_few_test_positives +4058,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asparaginase/glutaminase catalytic core,False,no_term_above_threshold +4059,87413,16.590197,0.63623047,Disulfide bond,keyword,87413,Disulfide bond,0.63623047,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6082058988184684,0.09890425204588559,0.0717766947275144,0.006172839506172839,1.3779438078244677,6.0,17.0,4.174311819550276,0.0034529279210178767,Active-site/ligand-environment boundary loops,True,assigned_and_evaluated +4060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flanking access and gating subregions,False,no_term_above_threshold +4061,85664,18.360943,0.96728516,Glycogen Phosphorylase B;,gene3d,63774,RNA-binding domain superfamily,0.89990234,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Nucleotide-sugar donor-binding loops,True,assigned_too_few_test_positives +4062,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular zinc metalloprotease scaffold,False,no_term_above_threshold +4063,38873,18.225012,0.9741211,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9501953,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9923179396092363,0.2600274187230709,0.002215330084182543,0.2,117.37637681159421,12.0,13.0,158.14588859416446,5.249804304397507e-26,P-loop Walker A region,True,assigned_and_evaluated +4064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane segments,False,no_term_above_threshold +4065,50806,18.620993,0.80029297,"Homeobox, conserved site",interpro,37071,Homeodomain,0.74658203,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,Diffuse FGAMS N-terminal activation,True,assigned_too_few_test_positives +4066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic functional region marker,False,no_term_above_threshold +4067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cores and acidic tails,False,no_term_above_threshold +4068,88058,17.719982,0.6074219,Signal,keyword,88058,Signal,0.6074219,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6337093437726328,0.12008716445658711,0.09127159946832078,,1.315712282419986,6.0,19.0,2.275248847193512,0.06387835227892309,IDR-rich cleavage junctions,True,assigned_and_evaluated +4069,36886,16.657244,0.7729492,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.7729492,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8571309470875945,0.12211005638602267,0.003544528134692069,,34.45029965790665,0.0,19.0,0.0,1.0,Active-site helix-loop junction,True,assigned_and_evaluated +4070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asparagine beta-hairpin loop hinge,False,no_term_above_threshold +4071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix feature,False,no_term_above_threshold +4072,37690,29.453764,0.8408203,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.8256836,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.7813650793650793,0.24509337038611043,0.0031014621178555605,0.2857142857142857,79.02510528020731,1.0,15.0,12.044646464646464,0.1301578102441321,Tandem-repeat scaffold detector,True,assigned_and_evaluated +4073,85762,23.356838,0.7416992,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.7416992,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,Oxidoreductase cofactor-binding core,True,assigned_too_few_test_positives +4074,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Rossmann-like scaffold,False,no_term_above_threshold +4075,85682,20.168188,0.67529297,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.67529297,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8087007168458782,0.5117733084372429,0.011076650420912717,0.48,46.20289428571429,12.0,16.0,76.69939965694682,3.2185348828532978e-21,Acidic aromatic nucleotide binding loops,True,assigned_and_evaluated +4076,85664,24.874765,0.98046875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98046875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,20.0,20.0,331.22777777777776,1.2127040143295405e-49,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +4077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-pass signal-anchor helices,False,no_term_above_threshold +4078,87276,39.37767,0.67089844,Cell membrane,keyword,88161,Transmembrane helix,0.63720703,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7352831942419753,0.4103369985214498,0.11120957022596367,0.5099601593625498,3.6897633691749485,13.0,15.0,7.111413891182678,2.2455566554410875e-10,TM helix initiation sites,True,assigned_and_evaluated +4079,24983,17.475899,0.70166016,mitochondrial inner membrane,go_cc,24983,mitochondrial inner membrane,0.70166016,179,go,GO:0005743,go_cc:go:GO:0005743,20.0,2257.0,0.7060125167635226,0.2529006003011846,0.008861320336730172,0.3,28.539832743988686,16.0,16.0,59.98088531187122,1.108456747039903e-28,Single-pass transmembrane helix,True,assigned_and_evaluated +4080,63831,19.795637,0.9121094,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9121094,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8585813712424107,0.010421507151861593,0.002658396101019052,,3.920223606958602,0.0,18.0,0.0,1.0,Exposed hydrophobic boundary motifs,True,assigned_and_evaluated +4081,36104,22.160772,0.9814453,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9814453,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Propeptides and glycine-rich loops,True,assigned_too_few_test_positives +4082,87239,16.138742,0.77001953,CF(1),keyword,87239,CF(1),0.77001953,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.998010728654448,0.650050038055153,0.008861320336730172,1.0,73.35814679452403,0.0,18.0,0.0,1.0,Hydrophobic alpha-helical scaffolds,True,assigned_and_evaluated +4083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal WxPCVD-like motif,False,no_term_above_threshold +4084,64058,21.968353,0.81933594,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.80126953,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9222024074899688,0.609671383534804,0.006202924235711121,0.7857142857142857,98.28773661700376,13.0,13.0,113.99808795411089,5.118200968948955e-27,Rossmann core beta strand,True,assigned_and_evaluated +4085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-proximal helical scaffolds,False,no_term_above_threshold +4086,38873,15.615401,0.875,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.69921875,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9951154529307282,0.731829573934837,0.002215330084182543,0.8,330.34786967418546,9.0,9.0,171.32471264367817,1.8650004750458193e-20,ABC pre-P-loop linker,True,assigned_and_evaluated +4087,85682,20.597414,0.6982422,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6982422,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7444175627240144,0.14302352989530048,0.011076650420912717,0.08,12.912164278947728,10.0,16.0,63.91616638078902,1.3553340271404987e-16,β-loop-α nucleotide pocket,True,assigned_and_evaluated +4088,27735,22.884443,0.79785156,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,88150,Transcription regulation,0.60839844,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.8203375512877978,0.460925901822527,0.011519716437749225,0.46153846153846156,40.011913862055515,14.0,18.0,35.18352722980948,4.559821496433899e-20,Leucine zipper dimerization helices,True,assigned_and_evaluated +4089,85664,23.704187,0.9892578,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9892578,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,N-terminal amphipathic tether helix,True,assigned_too_few_test_positives +4090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed amphipathic alpha-helix,False,no_term_above_threshold +4091,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical-repeat initiator,False,no_term_above_threshold +4092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic DE-rich interaction patches,False,no_term_above_threshold +4093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered segments,False,no_term_above_threshold +4094,87489,20.862888,0.81640625,GPI-anchor,keyword,88161,Transmembrane helix,0.64160156,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8222857142857143,0.027927178959363058,0.0031014621178555605,,9.004520415897488,0.0,18.0,0.0,1.0,C-terminal TM stop-transfer boundary,True,assigned_and_evaluated +4095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix–loop interface,False,no_term_above_threshold +4096,47717,15.801729,0.87060547,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.87060547,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,17.0,225.22773880194276,1.3994277175860336e-31,Helicase C-lobe/CTD activation,True,assigned_too_few_test_positives +4097,85664,16.500553,0.79785156,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.79785156,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,15.0,17.0,292.2598039215686,6.493650904665192e-36,Nucleotide-proximal loop–helix module,True,assigned_too_few_test_positives +4098,88051,16.73226,0.6948242,Serine protease inhibitor,keyword,28679,serine-type endopeptidase inhibitor activity,0.69433594,109,keywords,Serine protease inhibitor,keyword:keywords:Serine protease inhibitor,,,,,,,,0.0,19.0,0.0,1.0,ClpR N-terminal double repeat,True,assigned_too_few_test_positives +4099,37468,18.506283,0.9057617,"Zinc finger, RING-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.8388672,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,17.0,0.0,1.0,Active-site flanking helix,True,assigned_too_few_test_positives +4100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidohydrolase/carboxylase internal helices,False,no_term_above_threshold +4101,87697,16.106508,0.71972656,Knottin,keyword,87413,Disulfide bond,0.6074219,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.968723266514069,0.2947289287265386,0.017279574656623838,,17.056492106046093,0.0,19.0,0.0,1.0,Secreted cysteine-rich chitin binders,True,assigned_and_evaluated +4102,37894,19.434639,0.97509766,Short-chain dehydrogenase/reductase SDR,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.68847656,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,10.0,0.0,1.0,ABC pre-P-loop beta strand,True,assigned_too_few_test_positives +4103,49116,19.990261,0.82373047,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.82373047,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8935168738898757,0.228419256493027,0.002215330084182543,0.2,103.10845238095239,18.0,18.0,87.03795620437957,5.040547535858956e-35,MIF4G HEAT-repeat RNA scaffolds,True,assigned_and_evaluated +4104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD H-loop motif,False,no_term_above_threshold +4105,50763,15.617781,0.99658203,"Zinc finger, RING-type, conserved site",interpro,29166,zinc ion binding,0.8173828,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,17.0,20.0,258.56045918367346,2.6374258211212757e-39,Post-RING C-terminal helix,True,assigned_too_few_test_positives +4106,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-cleavage mature-domain activation,False,no_term_above_threshold +4107,46078,18.50626,0.9291992,Armadillo-like helical,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8354492,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,3.0,19.0,20.64439058171745,0.0007013915222968144,HEAT/MIF4G scaffolds with acidic IDRs,True,assigned_too_few_test_positives +4108,47529,17.844088,0.6801758,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6801758,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.5809069611780455,0.06575985821887462,0.007089056269384138,0.0625,9.276250000000001,6.0,16.0,28.99854085603113,6.531030514217132e-08,M14 transthyretin-like motif,True,assigned_and_evaluated +4109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal linker regions,False,no_term_above_threshold +4110,59211,21.842548,0.9892578,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9892578,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.999820788530466,0.9855684729064043,0.011076650420912717,1.0,88.97712173399017,17.0,17.0,244.34836065573774,1.3495568203358695e-40,NDP-sugar donor loop hotspot,True,assigned_and_evaluated +4111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-targeting folded catalytic domains,False,no_term_above_threshold +4112,85672,32.602543,0.71240234,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.71240234,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7327467607183952,0.35763992996882144,0.01595037660611431,0.4722222222222222,22.42203672054528,19.0,20.0,38.01338926174497,2.3117235620488766e-29,ATPase Toprim linker helix,True,assigned_and_evaluated +4113,49116,19.412966,0.8979492,Armadillo-type fold,interpro,64507,Ankyrin repeat-containing domain superfamily,0.8486328,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9934280639431616,0.4882539682539682,0.002215330084182543,0.4,220.39784126984128,10.0,20.0,43.518978102189784,1.4475001995303197e-14,Internal α-solenoid helical scaffolds,True,assigned_and_evaluated +4114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +4115,88009,26.027336,0.6743164,Repeat,keyword,88009,Repeat,0.6743164,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6672896297763743,0.17335383751037597,0.07266282676118742,,2.3857293369568207,6.0,19.0,2.799655644687928,0.02568930739739356,Internal mature-chain activation hotspots,True,assigned_and_evaluated +4116,39971,25.71708,0.9824219,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.97216797,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,16.0,18.0,588.8493827160494,4.036993795200243e-43,Metallophosphoesterase catalytic cores,True,assigned_too_few_test_positives +4117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic N-terminal/linker regions,False,no_term_above_threshold +4118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent NTase/palm core,False,no_term_above_threshold +4119,85672,50.394447,0.9511719,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.94921875,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9375781679923958,0.5390911057744266,0.01595037660611431,0.8611111111111112,33.79801738146892,11.0,17.0,25.891472562179235,5.64344048893498e-14,Walker A P-loop motif,True,assigned_and_evaluated +4120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical docking and capping motifs,False,no_term_above_threshold +4121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site helical hairpin,False,no_term_above_threshold +4122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible noncatalytic accessory domains,False,no_term_above_threshold +4123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WxGT polar loop repeats,False,no_term_above_threshold +4124,25169,21.226074,0.85791016,pilus,go_cc,87465,Fimbrium,0.82958984,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8971580817051511,0.5537763993501699,0.002215330084182543,0.8,249.9746666666667,0.0,20.0,0.0,1.0,Secretory ectodomains and low-complexity linkers,True,assigned_and_evaluated +4125,37468,21.531586,0.99560547,"Zinc finger, RING-type",interpro,88263,Zinc-finger,0.8227539,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,18.0,20.0,123.63801843317972,2.473152308631997e-36,RING finger Cys-His knuckle,True,assigned_too_few_test_positives +4126,82029,24.400404,0.9995117,MFS general substrate transporter like domains,gene3d,25079,plasma membrane,0.6074219,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Cytosolic helix-coil gating hinges,True,assigned_too_few_test_positives +4127,64058,20.68454,0.67089844,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.66503906,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8551366155021974,0.45652643846437757,0.006202924235711121,0.7142857142857143,73.59858368672144,8.0,10.0,91.19847036328872,3.454020325020956e-15,C-terminal helix-to-coil tails,True,assigned_and_evaluated +4128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory β-strand I/VTKG motif,False,no_term_above_threshold +4129,37690,20.25144,0.9868164,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9838867,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.976825396825397,0.07391428720029126,0.0031014621178555605,,23.832078030151056,0.0,13.0,0.0,1.0,Structural amphipathic alpha helices,True,assigned_and_evaluated +4130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic N-terminal targeting peptides,False,no_term_above_threshold +4131,88160,18.920876,0.85253906,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.85253906,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,18.0,20.0,260.4800970873786,4.917423262979944e-42,OM beta-barrel N-terminal periplasmic motif,True,assigned_too_few_test_positives +4132,45553,16.213573,0.7402344,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.70751953,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,0.0,18.0,0.0,1.0,Conserved Schlafen helix-strand motif,True,assigned_too_few_test_positives +4133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tat twin-arginine signal peptide,False,no_term_above_threshold +4134,59229,25.820179,0.70703125,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.70703125,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7800591646880229,0.49251081672678243,0.0101905183872397,0.5652173913043478,48.330300580536864,16.0,18.0,94.46781540899187,1.7760064537285212e-30,N6-adenine DNA MTase signature,True,assigned_and_evaluated +4135,52941,25.227564,0.9555664,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9350586,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,13.0,16.0,211.53739082969432,5.562434793025044e-29,MFS/SLC cytosolic bundle-linker loop,True,assigned_too_few_test_positives +4136,88152,17.261774,0.7402344,Transducer,keyword,88152,Transducer,0.7402344,76,keywords,Transducer,keyword:keywords:Transducer,,,,,,,,1.0,15.0,10.405061082024433,0.14902153562768009,HAMP signal-relay domains,True,assigned_too_few_test_positives +4137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global structure-agnostic activation,False,no_term_above_threshold +4138,37894,25.934565,0.9794922,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9794922,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,3.0,20.0,106.46607142857142,5.723605694031397e-06,Broad cytosolic loop activation,True,assigned_too_few_test_positives +4139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered propeptides and linkers,False,no_term_above_threshold +4140,37282,21.413746,0.9423828,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.93603516,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,4.0,13.0,68.70757706712763,5.305776141197594e-07,LRR loop and cap activation,True,assigned_too_few_test_positives +4141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short coil–element transition motif,False,no_term_above_threshold +4142,81858,27.734924,0.8457031,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8457031,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane alpha-helix bundles,True,assigned_too_few_test_positives +4143,88240,17.977541,0.67822266,Virulence,keyword,88240,Virulence,0.67822266,306,keywords,Virulence,keyword:keywords:Virulence,20.0,2257.0,0.7493853375055879,0.038697629521844246,0.008861320336730172,,4.3670274915401235,18.0,19.0,33.923755334281644,5.868554258102262e-27,Non-Sec effector targeting signals,True,assigned_and_evaluated +4144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase C-terminal autoinhibitory beta-strands,False,no_term_above_threshold +4145,35372,15.734537,0.9736328,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9736328,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,13.0,18.0,506.58366013071895,1.529962910518254e-33,Conserved membrane-interface helix motif,True,assigned_too_few_test_positives +4146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ASNS PYLPKHILYR-like motif,False,no_term_above_threshold +4147,82029,31.165384,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Transmembrane helix N-cap motif,True,assigned_too_few_test_positives +4148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-dependent amide ligase core,False,no_term_above_threshold +4149,37446,17.281391,0.94091797,F-box domain,interpro,37446,F-box domain,0.94091797,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.8626349206349205,0.011914660778606796,0.0031014621178555605,,3.84162705390222,0.0,20.0,0.0,1.0,Secondary structure capping residues,True,assigned_and_evaluated +4150,45324,17.349707,0.8754883,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.8754883,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9951154529307282,0.20396505455328984,0.002215330084182543,,92.06982562535504,6.0,10.0,328.18899082568805,1.5680668442433695e-14,Polar beta-solenoid repeat domains,True,assigned_and_evaluated +4151,59211,18.1796,0.9848633,Nucleotide-diphospho-sugar transferases,interpro,59224,Alpha/Beta hydrolase fold,0.8925781,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9966756272401434,0.7200461374249153,0.011076650420912717,0.96,65.00576528672136,17.0,17.0,244.34836065573774,1.3495568203358695e-40,Glycosyltransferase NDP-sugar anchoring beta-strands,True,assigned_and_evaluated +4152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma-like promoter-melting module,False,no_term_above_threshold +4153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long alpha-helical scaffolds,False,no_term_above_threshold +4154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/alpha-solenoid scaffolds,False,no_term_above_threshold +4155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hepadnaviral TP and nuclear LCDs,False,no_term_above_threshold +4156,63951,19.356668,0.9003906,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.83203125,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8827105575326215,0.455746328198217,0.003987594151528578,0.4444444444444444,114.29105141593064,14.0,15.0,150.39531531531532,5.511315841505439e-30,Sarcomeric Ig disordered linkers,True,assigned_and_evaluated +4157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal IDRs and signal peptides,False,no_term_above_threshold +4158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic beta-loop entrance motif,False,no_term_above_threshold +4159,43624,18.112148,0.85302734,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.85302734,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8672885988398038,0.03437634113619809,0.007089056269384138,,4.849212621524943,5.0,13.0,33.771949699784756,4.399800383609211e-07,Charged helix-capping turn motifs,True,assigned_and_evaluated +4160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Biotin carboxylase YDS motif,False,no_term_above_threshold +4161,50338,16.590906,0.96728516,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.64208984,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix boundary signature,True,assigned_too_few_test_positives +4162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic surface patches,False,no_term_above_threshold +4163,36886,18.570164,0.8574219,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.8574219,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8624388617163182,0.16706378975846187,0.003544528134692069,,47.132871685606055,0.0,20.0,0.0,1.0,Hydrophobic amphipathic helical scaffolds,True,assigned_and_evaluated +4164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved central USP helix,False,no_term_above_threshold +4165,72011,16.655787,0.9667969,"AMP-binding enzyme, C-terminal domain superfamily",interpro,45290,Protein kinase-like domain superfamily,0.8886719,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Histidine-centered kinase phosphotransfer motif,True,assigned_too_few_test_positives +4166,87326,23.319708,0.6020508,Coiled coil,keyword,87326,Coiled coil,0.6020508,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.5871071561839214,0.20198048951470118,0.03943287549844927,0.16853932584269662,5.122134436344726,18.0,19.0,11.943973912366028,6.647492796621427e-19,Charged coiled coil scaffolds,True,assigned_and_evaluated +4167,64507,37.798126,0.9946289,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9946289,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9998022933965994,0.9575757575757577,0.003987594151528578,1.0,240.1387205387206,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin-repeat C-terminal activation,True,assigned_and_evaluated +4168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pan-protein activation across nucleoproteins,False,no_term_above_threshold +4169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-associated helices and coiled-coils,False,no_term_above_threshold +4170,81799,19.136795,0.8666992,1.10.8.60,gene3d,32577,protein heterodimerization activity,0.76660156,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,1.0,12.0,48.23705501618122,0.034574433519622916,Basic amphipathic helical interfaces,True,assigned_too_few_test_positives +4171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved aminotransferase core motifs,False,no_term_above_threshold +4172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic-aromatic GNAT surface patch,False,no_term_above_threshold +4173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved BAH domain segments,False,no_term_above_threshold +4174,88263,16.12886,0.68652344,Zinc-finger,keyword,88263,Zinc-finger,0.68652344,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8711371811641596,0.12448528356998424,0.014621178555604785,,8.514038939922862,2.0,13.0,4.008942980096826,0.1409524793897581,Disordered kinase regulatory tails,True,assigned_and_evaluated +4175,37341,24.284838,0.9970703,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99316406,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9997508719481814,0.9727326682925361,0.011962782454585734,1.0,81.31324564208349,17.0,17.0,145.4170731707317,7.415328584131598e-37,WD-repeat beta-propeller core residues,True,assigned_and_evaluated +4176,87108,22.282537,0.97558594,ANK repeat,keyword,46079,Tetratricopeptide-like helical domain superfamily,0.9614258,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9934756820877817,0.26647762568815203,0.003987594151528578,,66.82666679757324,1.0,19.0,8.914623205741627,0.17191850794325853,Alpha-helical repeat solenoids,True,assigned_and_evaluated +4177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic N-terminal spacers,False,no_term_above_threshold +4178,72011,15.899434,0.9033203,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9033203,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,11.0,0.0,1.0,Anion-recognition interface hotspots,True,assigned_too_few_test_positives +4179,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase catalytic β-strands,False,no_term_above_threshold +4180,58239,17.163937,0.7363281,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7363281,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7872913847541724,0.047045277942267795,0.017722640673460344,,2.6545298078924606,3.0,13.0,8.273416901799344,0.008645095130632944,Hinge residues; C-terminal linker motifs,True,assigned_and_evaluated +4181,64026,15.67035,0.84765625,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.80615234,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.82252332296757,0.015565170748865282,0.002658396101019052,,5.855098396698157,0.0,15.0,0.0,1.0,Transmembrane alpha-helical segments,True,assigned_and_evaluated +4182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domains and active sites,False,no_term_above_threshold +4183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Distal C-terminal preference,False,no_term_above_threshold +4184,37468,20.203356,0.9814453,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.91308594,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,9.0,19.0,65.0726412806209,1.0629504968065308e-14,Short segments near Zn/RING,True,assigned_too_few_test_positives +4185,87326,28.153976,0.6845703,Coiled coil,keyword,87326,Coiled coil,0.6845703,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6856938513205356,0.16298588226230254,0.03943287549844927,,4.133248722090077,6.0,15.0,5.043011207443435,0.0011713809902942907,Long coiled-coil stalks,True,assigned_and_evaluated +4186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular T/G-rich beta-solenoid repeats,False,no_term_above_threshold +4187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal hydrophobic alpha helix,False,no_term_above_threshold +4188,61392,17.638344,0.9399414,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.9399414,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.8893968253968254,0.033421080725665686,0.0031014621178555605,,10.77591131397535,0.0,13.0,0.0,1.0,Alpha-helix N-cap signal,True,assigned_and_evaluated +4189,46284,16.304932,0.9868164,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9868164,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,8.0,11.0,867.2145454545455,6.30908014835849e-23,Aromatic NAD(P)H-binding loop,True,assigned_too_few_test_positives +4190,87697,18.556997,0.8222656,Knottin,keyword,87413,Disulfide bond,0.6894531,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9159499202330581,0.09921482805013034,0.017279574656623838,,5.741740177157543,0.0,17.0,0.0,1.0,Helix N-caps and beta-edge motifs,True,assigned_and_evaluated +4191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal outer-membrane β-barrel face,False,no_term_above_threshold +4192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix–loop caps,False,no_term_above_threshold +4193,63960,40.1431,0.92871094,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.92871094,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,C-terminal flavoprotein catalytic lobe,True,assigned_too_few_test_positives +4194,64003,24.945202,0.9428711,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.92089844,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9996540134440491,0.9513888888888891,0.003987594151528578,1.0,238.58719135802474,16.0,16.0,130.4617067833698,5.252801912935239e-34,C2H2 ZNF regulatory IDRs,True,assigned_and_evaluated +4195,36535,15.750845,0.95214844,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9423828,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.989741878059635,0.4306186806554454,0.004430660168365086,0.6,97.19063622393404,0.0,9.0,0.0,1.0,Nucleotide-binding catalytic core,True,assigned_and_evaluated +4196,45290,34.730938,0.97216797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97216797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9604586589880707,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,17.0,20.0,62.41114532019704,6.28912244422708e-29,Kinase C-lobe activation segment,True,assigned_and_evaluated +4197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic helix-loop linkers,False,no_term_above_threshold +4198,88152,16.674839,0.6279297,Transducer,keyword,88152,Transducer,0.6279297,76,keywords,Transducer,keyword:keywords:Transducer,,,,,,,,9.0,9.0,156.0759162303665,4.310597049396384e-20,Cytosolic amphipathic coupling helices,True,assigned_too_few_test_positives +4199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain core scaffold,False,no_term_above_threshold +4200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich coiled-coil scaffolds,False,no_term_above_threshold +4201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Inteins, HhC, and HENs",False,no_term_above_threshold +4202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-protein low-complexity helices,False,no_term_above_threshold +4203,47531,16.383894,0.85009766,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.85009766,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,13.0,14.0,234.5862590799032,2.2574422526431795e-30,C-terminal helical cap motif,True,assigned_too_few_test_positives +4204,36091,17.452383,1.0,GNAT domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.73339844,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,GNAT acetyl-CoA pocket helix,True,assigned_too_few_test_positives +4205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity with motif peaks,False,no_term_above_threshold +4206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic OmpA-like PG-binding domain,False,no_term_above_threshold +4207,72011,22.58705,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.94433594,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,13.0,13.0,590.3069306930694,2.4178087537758372e-36,ANL adenylation domains,True,assigned_too_few_test_positives +4208,38317,19.193726,0.85498047,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.75,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7724761904761904,0.04594072687256466,0.0031014621178555605,,14.812602935911205,0.0,18.0,0.0,1.0,Exposed repeats and disordered regions,True,assigned_and_evaluated +4209,36091,23.523886,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,19.0,357.48767488341105,5.778092987514223e-45,GNAT cofactor-binding micro-motif,True,assigned_too_few_test_positives +4210,87276,33.828526,0.640625,Cell membrane,keyword,88161,Transmembrane helix,0.60546875,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7872696651082608,0.5615284100863087,0.11120957022596367,0.6334661354581673,5.0492813608159315,17.0,17.0,8.205477566749243,6.762424294023822e-16,Internal TM helices,True,assigned_and_evaluated +4211,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central helical interaction cores,False,no_term_above_threshold +4212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site gating loops,False,no_term_above_threshold +4213,88178,18.665592,0.7207031,Ubiquinone,keyword,6543,NADH:ubiquinone reductase (H+-translocating),0.7192383,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,8.0,12.0,336.84180790960454,2.3227823881985687e-19,Complex I/NDH-1 C-terminal loop-helix motif,True,assigned_too_few_test_positives +4214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-lined substrate-binding cores,False,no_term_above_threshold +4215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved internal helix-strand segment,False,no_term_above_threshold +4216,82029,19.013788,0.8779297,MFS general substrate transporter like domains,gene3d,25079,plasma membrane,0.6064453,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix-loop junctions,True,assigned_too_few_test_positives +4217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase Walker A flank,False,no_term_above_threshold +4218,72011,17.246752,0.9824219,"AMP-binding enzyme, C-terminal domain superfamily",interpro,37071,Homeodomain,0.8408203,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,9.0,0.0,1.0,Pre-motif cytosolic scaffolds,True,assigned_too_few_test_positives +4219,47529,32.139046,0.94628906,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.94628906,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9643155957161982,0.530823564332269,0.007089056269384138,0.875,74.87929904362069,12.0,20.0,46.39766536964981,5.710117127717098e-18,Mucin-like acidic ectodomain linkers,True,assigned_and_evaluated +4220,59224,30.556429,0.76904297,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.76904297,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.8544761904761906,0.5857600816135049,0.0031014621178555605,0.5714285714285714,188.8657863145258,16.0,16.0,137.37557603686636,2.308526036036146e-34,alpha/beta-hydrolase cap/lid subdomain,True,assigned_and_evaluated +4221,48241,19.694613,0.9692383,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9692383,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,19.0,20.0,367.79188311688307,1.7236096947594326e-47,Hydrophobic jelly-roll beta-strand,True,assigned_too_few_test_positives +4222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity scaffolds and S8 serine,False,no_term_above_threshold +4223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAPS-dependent sulfotransferase catalytic domain,False,no_term_above_threshold +4224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDR/low-complexity aromatic hotspots,False,no_term_above_threshold +4225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic helices,False,no_term_above_threshold +4226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MacB periplasmic loop motif,False,no_term_above_threshold +4227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic helical scaffolds,False,no_term_above_threshold +4228,88161,75.778404,0.86083984,Transmembrane helix,keyword,88161,Transmembrane helix,0.86083984,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.9050665988947972,0.7062196090060551,0.1847585290208241,0.9016786570743405,3.822392464092725,14.0,17.0,4.469699322605692,3.978602330867186e-08,Transmembrane helix interfaces,True,assigned_and_evaluated +4229,63960,20.799376,0.7734375,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.7734375,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,10.0,16.0,120.98417207792208,2.3267266530627456e-19,Oxygenase catalytic core subdomain,True,assigned_too_few_test_positives +4230,55053,17.898912,0.9848633,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9848633,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,12.0,12.0,552.0462962962963,3.0471251534694055e-33,Group-transfer C-lobe beta-strand,True,assigned_too_few_test_positives +4231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FliD/HAP2 central core activation,False,no_term_above_threshold +4232,88058,94.88083,0.8955078,Signal,keyword,88058,Signal,0.8955078,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9130237203732017,0.664264450994357,0.09127159946832078,0.8543689320388349,7.277887698515844,19.0,19.0,7.204954682779456,1.200803819710704e-16,Sec/Tat signal peptide h-region,True,assigned_and_evaluated +4233,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Und-P sugar-1-P transferase loop,False,no_term_above_threshold +4234,30107,16.849613,0.83251953,nickel cation binding,go_mf,30107,nickel cation binding,0.83251953,31,go,GO:0016151,go_mf:go:GO:0016151,20.0,2257.0,0.9664617791685293,0.3005033993653833,0.008861320336730172,,33.9118086183835,3.0,17.0,105.21352941176472,5.793845732104379e-06,Terminal catalytic cofactor-binding subdomain,True,assigned_and_evaluated +4235,42054,16.956951,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,15.0,632.3439393939394,8.708778353051357e-39,Radical SAM post-motif helix,True,assigned_too_few_test_positives +4236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Integrin βI/VWFA disulfide loop,False,no_term_above_threshold +4237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular β-α junction motif,False,no_term_above_threshold +4238,59211,20.69789,0.9897461,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9996415770609319,0.9440009382774089,0.011076650420912717,1.0,85.22440470768447,17.0,17.0,244.34836065573774,1.3495568203358695e-40,Nucleotide-sugar DxD motif,True,assigned_and_evaluated +4239,37690,16.941862,0.9248047,Ankyrin repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.91552734,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9545079365079365,0.04378245940875204,0.0031014621178555605,,14.116715840793336,0.0,18.0,0.0,1.0,Helix-start N-cap residues,True,assigned_and_evaluated +4240,87419,15.903096,0.90771484,EGF-like domain,keyword,87419,EGF-like domain,0.90771484,54,keywords,EGF-like domain,keyword:keywords:EGF-like domain,,,,,,,,0.0,14.0,0.0,1.0,Plant scaffold and catalytic patches,True,assigned_too_few_test_positives +4241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC TMD and coupling helices,False,no_term_above_threshold +4242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic globular domain cores,False,no_term_above_threshold +4243,49121,16.534245,0.82714844,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.82714844,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,1.0,13.0,75.18411097099623,0.02245028141967594,Sensory-to-output linkers,True,assigned_too_few_test_positives +4244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CoA-enzyme catalytic cores,False,no_term_above_threshold +4245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich beta-sheet cores,False,no_term_above_threshold +4246,43583,16.6415,0.9277344,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9277344,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,14.0,15.0,389.1347319347319,8.857790808758203e-36,Trypsin-fold serine protease catalytic domain,True,assigned_and_evaluated +4247,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Myosin motor actin-binding surface,False,no_term_above_threshold +4248,55054,30.395994,0.98583984,HAD superfamily,interpro,55054,HAD superfamily,0.98583984,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8993783303730017,0.8004430660168366,0.002215330084182543,0.8,361.32000000000005,16.0,16.0,334.9494382022472,1.8172363340572328e-40,HAD-like Asp-based phosphatases,True,assigned_and_evaluated +4249,46079,38.41547,0.9921875,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9921875,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9957150692444809,0.760290457405842,0.0057598582188746125,0.9230769230769231,131.99812018192196,17.0,17.0,93.1578125,1.2704632402379146e-33,TPR helix A register,True,assigned_and_evaluated +4250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-rich early N-termini,False,no_term_above_threshold +4251,37071,24.432375,0.9868164,Homeodomain,interpro,87384,DNA-binding,0.68847656,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,16.0,0.0,1.0,HTH DNA recognition helices,True,assigned_too_few_test_positives +4252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic USP helix-turn motif,False,no_term_above_threshold +4253,87489,16.960386,0.8066406,GPI-anchor,keyword,88161,Transmembrane helix,0.66259766,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8093333333333335,0.020103216843774106,0.0031014621178555605,,6.481851488056879,0.0,18.0,0.0,1.0,Cytosolic juxtamembrane linker,True,assigned_and_evaluated +4254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended mid-protein scaffolds,False,no_term_above_threshold +4255,25169,18.887276,0.7495117,pilus,go_cc,25169,pilus,0.7495117,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8918294849023091,0.09629710328391726,0.002215330084182543,,43.468512422360256,0.0,18.0,0.0,1.0,Acidic polyanion/metal-binding surfaces,True,assigned_and_evaluated +4256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long low-complexity tandem repeats,False,no_term_above_threshold +4257,37430,19.547337,1.0,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,0.9838867,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,17.0,17.0,484.7235772357723,1.7310182502290982e-45,REC domain DD motif,True,assigned_too_few_test_positives +4258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic membrane-interacting segments,False,no_term_above_threshold +4259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered tails and hydrophobic helices,False,no_term_above_threshold +4260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hairpin module,False,no_term_above_threshold +4261,45324,16.063135,0.99658203,Pectin lyase fold/virulence factor,interpro,64507,Ankyrin repeat-containing domain superfamily,0.7763672,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9989342806394317,0.525952380952381,0.002215330084182543,1.0,237.41490476190478,16.0,16.0,546.9816513761467,8.086221761424609e-44,Hydrophobic beta-strand scaffolds,True,assigned_and_evaluated +4262,64475,17.077242,0.9189453,ACP-like superfamily,interpro,43643,Phosphopantetheine binding ACP domain,0.9008789,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9225284519402167,0.8336367147842556,0.0057598582188746125,0.8461538461538461,144.73215886677423,13.0,18.0,384.4608134920635,6.374362979144664e-32,PKS KR-ACP-DH-MAT,True,assigned_and_evaluated +4263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Archaeal Pelota central motif,False,no_term_above_threshold +4264,37640,27.396906,0.97558594,EF-hand domain,interpro,46081,EF-hand domain pair,0.96435547,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,3.0,17.0,52.87112030741946,4.459803556544486e-05,Acidic extracellular calcium-binding domains,True,assigned_too_few_test_positives +4265,30398,16.757168,0.70996094,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.6689453,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6700599044766454,0.3088865860847977,0.004873726185201595,0.2727272727272727,63.377911344853494,15.0,15.0,72.00603864734299,4.153748814633804e-28,ABC ATPase A-loop beta1,True,assigned_and_evaluated +4266,45290,29.537802,0.9741211,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9741211,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9603558206499384,0.9125309781047484,0.0057598582188746125,0.9230769230769231,158.429416737109,14.0,15.0,68.52988505747128,3.0474954144632634e-25,Glycine-rich ATP-binding P-loop,True,assigned_and_evaluated +4267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Y-family little-finger DNA-binding surface,False,no_term_above_threshold +4268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-core cofactor-site activation,False,no_term_above_threshold +4269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding and phosphate-handling cores,False,no_term_above_threshold +4270,46078,20.547977,0.96777344,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.96777344,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,18.0,18.0,130.74780701754386,3.9193799829466193e-38,HEAT/ARM interhelical turns and N-caps,True,assigned_too_few_test_positives +4271,87882,24.824621,0.8935547,Palmitate,keyword,88058,Signal,0.79052734,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8309269954094477,0.009179981169624967,0.002658396101019052,,3.4532029166405915,2.0,19.0,7.012172890326374,0.053991397200025014,Secreted cysteine-rich peptides,True,assigned_and_evaluated +4272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic hydrophobic core tracts,False,no_term_above_threshold +4273,88154,17.56072,0.73095703,Transit peptide,keyword,88154,Transit peptide,0.73095703,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.7549820868786384,0.03472040221041024,0.010633584404076208,,3.2651644912039965,3.0,17.0,5.152474505963012,0.03210423847664967,Alpha-helical membrane anchors,True,assigned_and_evaluated +4274,82029,17.34514,0.86083984,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7192383,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,N-terminal signal anchor,True,assigned_too_few_test_positives +4275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase N-domain TGxGY,False,no_term_above_threshold +4276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity interaction loops,False,no_term_above_threshold +4277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich β–α N-cap motif,False,no_term_above_threshold +4278,85664,20.832193,0.98046875,Glycogen Phosphorylase B;,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8330078,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Hydrophobic acceptor-binding surface,True,assigned_too_few_test_positives +4279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal acidic aromatic binding loops,False,no_term_above_threshold +4280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,aaRS N-terminal tRNA-binding surface,False,no_term_above_threshold +4281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal alpha helix,False,no_term_above_threshold +4282,85364,24.00343,0.8691406,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8691406,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,SBP C-terminal helix/tail region,True,assigned_too_few_test_positives +4283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane beta-barrel loops,False,no_term_above_threshold +4284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CENP-B/pogo DDE-1 transposases,False,no_term_above_threshold +4285,45288,18.067581,0.9838867,CheY-like superfamily,interpro,85656,alpha/beta hydrolase,0.7871094,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,16.0,16.0,462.17829457364337,1.1105476792425275e-42,Two-component hydrophobic switch helix,True,assigned_too_few_test_positives +4286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cap activation,False,no_term_above_threshold +4287,45714,18.640804,0.9916992,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.99072266,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,Helical diiron carboxylate scaffolds,True,assigned_too_few_test_positives +4288,88058,23.983286,0.6489258,Signal,keyword,88058,Signal,0.6489258,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6597397433409231,0.12187469541239337,0.09127159946832078,,1.3352970269212225,4.0,20.0,1.4409909365558913,0.4670478563492871,Low-complexity disordered regions,True,assigned_and_evaluated +4289,25169,20.788773,0.86572266,pilus,go_cc,25169,pilus,0.86572266,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8985790408525755,0.8004430660168366,0.002215330084182543,0.8,361.32000000000005,0.0,11.0,0.0,1.0,RnfG posttransmembrane beta motif,True,assigned_and_evaluated +4290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-to-helix TM boundary capping,False,no_term_above_threshold +4291,72011,16.956518,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,63774,RNA-binding domain superfamily,0.95703125,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Nonacidic helical scaffold triads,True,assigned_too_few_test_positives +4292,38317,25.899956,0.98779297,Pentatricopeptide repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.83740234,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.979111111111111,0.07360773226557464,0.0031014621178555605,,23.733235960485995,0.0,13.0,0.0,1.0,NBD helical lid/switch,True,assigned_and_evaluated +4293,38317,21.821735,0.96484375,Pentatricopeptide repeat,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8803711,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9325714285714286,0.024802703091108505,0.0031014621178555605,,7.9971001252331275,0.0,17.0,0.0,1.0,REC and HK helix hydrophobics,True,assigned_and_evaluated +4294,48883,16.080109,0.9980469,Pyridoxal phosphate-dependent transferase,interpro,87986,Pyridoxal phosphate,0.84033203,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,18.0,18.0,480.8145161290322,6.533334885052963e-48,PLP active-site lid loop,True,assigned_too_few_test_positives +4295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,QueA PLPPY/PIPPY motif activation,False,no_term_above_threshold +4296,85664,18.637716,0.9785156,Glycogen Phosphorylase B;,gene3d,59224,Alpha/Beta hydrolase fold,0.9267578,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +4297,45289,22.537985,0.9223633,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.9223633,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,0.0,18.0,0.0,1.0,Beta-to-alpha loop linkers,True,assigned_too_few_test_positives +4298,82029,22.089136,0.9975586,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6645508,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Transporter TM helix hotspots,True,assigned_too_few_test_positives +4299,36104,16.214443,0.8857422,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8857422,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Extended acidic disordered regions,True,assigned_too_few_test_positives +4300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type II glycosyltransferase catalytic ectodomains,False,no_term_above_threshold +4301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic/charged binding-pocket segments,False,no_term_above_threshold +4302,48883,21.929487,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,16.0,16.0,480.8145161290322,6.075488456631373e-43,PLP lysine-flanking glycine-aromatic loop,True,assigned_too_few_test_positives +4303,49116,25.853556,0.97509766,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97509766,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9992007104795736,0.7933333333333332,0.002215330084182543,0.8,358.11066666666665,15.0,20.0,65.27846715328467,3.0792553979016777e-25,Hydrophobic alpha-solenoid helices,True,assigned_and_evaluated +4304,46078,17.520788,0.9760742,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.97314453,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,19.0,19.0,130.74780701754386,3.676010515894859e-40,Helical scaffold repeat boundaries,True,assigned_too_few_test_positives +4305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature-chain N-terminus activation,False,no_term_above_threshold +4306,37314,16.519215,0.95458984,"Helicase, C-terminal domain-like",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.765625,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,0.0,8.0,0.0,1.0,ABC ATPase H-loop motif,True,assigned_too_few_test_positives +4307,55053,22.330338,0.98535156,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,13.0,552.0462962962963,5.9319613712133276e-36,Acyltransferase condensation-domain motif hotspots,True,assigned_too_few_test_positives +4308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-hairpin recognition loop,False,no_term_above_threshold +4309,63951,19.475756,0.94677734,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.91064453,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9384143930407276,0.3122586197441549,0.003987594151528578,,78.3075227513953,0.0,16.0,0.0,1.0,Extracellular glycosylated loops,True,assigned_and_evaluated +4310,59229,31.082458,0.9716797,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9716797,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.882079327390915,0.7453981463895284,0.0101905183872397,0.7391304347826086,73.14624419135502,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Post-motif I helix,True,assigned_and_evaluated +4311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal active-site upstream segment,False,no_term_above_threshold +4312,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic C-terminal tail feature,False,no_term_above_threshold +4313,36449,19.646526,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,12.0,19.0,672.4172932330827,2.87948653421866e-32,Pathway-lining TM helices,True,assigned_too_few_test_positives +4314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracytoplasmic regions,False,no_term_above_threshold +4315,15821,16.427473,0.6713867,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6713867,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,10.0,0.0,1.0,Soluble domain regional activation,True,assigned_too_few_test_positives +4316,32561,15.752077,0.83203125,"proton-transporting ATPase activity, rotational mechanism",go_mf,87326,Coiled coil,0.60546875,35,go,GO:0046961,go_mf:go:GO:0046961,,,,,,,,0.0,19.0,0.0,1.0,Heptad-repeat coiled-coil scaffolds,True,assigned_too_few_test_positives +4317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,STAS-like cytosolic interaction modules,False,no_term_above_threshold +4318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helix near active site,False,no_term_above_threshold +4319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and IDRs,False,no_term_above_threshold +4320,38317,17.834436,0.96972656,Pentatricopeptide repeat,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.88964844,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9585396825396825,0.03895317523205702,0.0031014621178555605,,12.559616642678956,0.0,19.0,0.0,1.0,Helical DNA-binding residue hotspot,True,assigned_and_evaluated +4321,88161,73.55449,0.8076172,Transmembrane helix,keyword,88161,Transmembrane helix,0.8076172,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.822754405171515,0.6113820730345948,0.1847585290208241,0.7194244604316546,3.309087143498994,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,Cytosolic juxtamembrane basic helix,True,assigned_and_evaluated +4322,39971,26.987795,1.0,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,16.0,18.0,588.8493827160494,4.036993795200243e-43,Metallophosphoesterase active site,True,assigned_too_few_test_positives +4323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass membrane enzyme helices,False,no_term_above_threshold +4324,50338,17.875298,0.94677734,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6010742,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Exofacial TM helix exits,True,assigned_too_few_test_positives +4325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topoisomerase IA strand-passage gate,False,no_term_above_threshold +4326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretion-associated low-complexity segments,False,no_term_above_threshold +4327,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature outer membrane beta-barrels,False,no_term_above_threshold +4328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic recognition helix,False,no_term_above_threshold +4329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar active-site lid loops,False,no_term_above_threshold +4330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding-site gating segments,False,no_term_above_threshold +4331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal ordered structural scaffolds,False,no_term_above_threshold +4332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil assembly scaffolds,False,no_term_above_threshold +4333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PCMH-type FAD-binding hydrophobic motif,False,no_term_above_threshold +4334,64620,18.965448,0.92626953,Histidine kinase/HSP90-like ATPase superfamily,interpro,50338,"GPCR, rhodopsin-like, 7TM",0.83251953,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,16.0,17.0,304.9667519181586,4.501986146074166e-39,Histidine kinase switch helix,True,assigned_too_few_test_positives +4335,82029,21.69431,0.99853516,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7163086,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Transmembrane helix architecture signal,True,assigned_too_few_test_positives +4336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral basic recognition loops,False,no_term_above_threshold +4337,29679,16.273844,0.77490234,FMN binding,go_mf,29679,FMN binding,0.77490234,25,go,GO:0010181,go_mf:go:GO:0010181,,,,,,,,0.0,15.0,0.0,1.0,Active-site buttress helix,True,assigned_too_few_test_positives +4338,85664,23.204233,0.97802734,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.97802734,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Glycosyltransferase helical donor-site motif,True,assigned_too_few_test_positives +4339,50806,15.903912,0.7675781,"Homeobox, conserved site",interpro,37071,Homeodomain,0.75097656,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,18.0,0.0,1.0,C-terminal secondary structure elements,True,assigned_too_few_test_positives +4340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helix boundary sensor,False,no_term_above_threshold +4341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal SPOR domain activation,False,no_term_above_threshold +4342,82597,18.483267,0.6538086,Tetratricopeptide repeat domain,gene3d,46079,Tetratricopeptide-like helical domain superfamily,0.65185547,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.6109625668449198,0.17750758324528818,0.0057598582188746125,0.15384615384615385,30.818047337278106,11.0,20.0,53.580964052287584,4.5879814030648325e-17,Noncatalytic helical interaction scaffolds,True,assigned_and_evaluated +4343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged intrinsically disordered regions,False,no_term_above_threshold +4344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal domain-scale detector,False,no_term_above_threshold +4345,85682,16.588488,0.84716797,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7861328,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9521415770609318,0.14606932933220754,0.011076650420912717,,13.187139052111696,1.0,14.0,7.3047047292330305,0.2058664264707413,Receiver domain downstream loop signal,True,assigned_and_evaluated +4346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase H-like nucleases; signal anchors,False,no_term_above_threshold +4347,87326,18.59027,0.60595703,Coiled coil,keyword,87326,Coiled coil,0.60595703,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6606591276586924,0.1565392110269481,0.03943287549844927,0.06741573033707865,3.9697640369418186,10.0,19.0,6.635541062425571,8.943846718676625e-07,Disordered N-terminal regulatory tails,True,assigned_and_evaluated +4348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral capsid assembly protease signature,False,no_term_above_threshold +4349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helices flanking catalytic motifs,False,no_term_above_threshold +4350,36914,19.22258,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.99902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,14.0,19.0,542.361273554256,1.4977066904732853e-36,Glycosyltransferase nucleotide-sugar binding loop,True,assigned_too_few_test_positives +4351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic loops of membrane proteins,False,no_term_above_threshold +4352,37894,22.10295,0.83740234,Short-chain dehydrogenase/reductase SDR,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6010742,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,9.0,0.0,1.0,ABC NBD beta1 hydrophobic motif,True,assigned_too_few_test_positives +4353,37468,15.996136,0.7651367,"Zinc finger, RING-type",interpro,88263,Zinc-finger,0.64697266,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,7.0,16.0,60.10181451612903,2.3968330824342925e-11,Acidic S/T/P-rich IDR tails,True,assigned_too_few_test_positives +4354,48767,17.78464,0.95703125,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.95703125,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,19.0,0.0,1.0,Noncatalytic extracellular/secretory binding modules,True,assigned_too_few_test_positives +4355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Molybdopterin Mo-transferase core,False,no_term_above_threshold +4356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal interaction segment,False,no_term_above_threshold +4357,59224,33.34405,0.98046875,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.98046875,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,18.0,18.0,137.37557603686636,1.6332112516921354e-38,Serine hydrolase nucleophile elbow,True,assigned_and_evaluated +4358,88058,23.078325,0.6430664,Signal,keyword,88058,Signal,0.6430664,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6421305259570278,0.11516987659632932,0.09127159946832078,,1.2618369489219188,7.0,20.0,2.5217341389728096,0.024798531661208274,Low complexity disordered regions,True,assigned_and_evaluated +4359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich disordered flanking linkers,False,no_term_above_threshold +4360,37894,17.730646,0.74316406,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.74316406,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,12.0,0.0,1.0,ABC NBD Q-loop region,True,assigned_too_few_test_positives +4361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Divalent-cation phosphate-binding motifs,False,no_term_above_threshold +4362,47529,27.072208,0.9667969,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9667969,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9912427487728693,0.38804257202239345,0.007089056269384138,0.3125,54.73825531590888,1.0,17.0,4.548790722514687,0.3136141447357415,Short hydrophobic/aromatic loop/strand motifs,True,assigned_and_evaluated +4363,87326,37.90587,0.7553711,Coiled coil,keyword,87326,Coiled coil,0.7553711,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7986494050333762,0.27069141530770346,0.03943287549844927,0.14606741573033707,6.8646126331403,12.0,20.0,7.564516811165151,8.54613056014215e-09,Coiled-coil heptad hydrophobic core,True,assigned_and_evaluated +4364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GST-like N-terminal alpha1 helix,False,no_term_above_threshold +4365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +4366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic glycine-rich recognition loops,False,no_term_above_threshold +4367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic N-terminal beta-strand motif,False,no_term_above_threshold +4368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop/turn motif,False,no_term_above_threshold +4369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-solenoid spikes and FG repeats,False,no_term_above_threshold +4370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat-based protein assembly scaffolds,False,no_term_above_threshold +4371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA-binding beta-core domains,False,no_term_above_threshold +4372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site bordering loop insert,False,no_term_above_threshold +4373,81685,24.635275,0.9921875,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.98535156,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9994432071269487,0.9537037037037038,0.005316792202038104,0.9166666666666666,179.37577160493828,17.0,17.0,85.66235632183908,5.1673760881485446e-33,HxD motif -1 residue,True,assigned_and_evaluated +4374,4066,19.028854,0.9589844,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9589844,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.8896092362344582,0.18958592315969364,0.002215330084182543,,85.57908571428571,11.0,20.0,395.0789156626506,1.0209997197957049e-26,Compositionally biased interaction segments,True,assigned_and_evaluated +4375,52940,17.131905,0.9453125,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.86816406,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,13.0,0.0,1.0,Active-site helix-capping loops,True,assigned_too_few_test_positives +4376,61392,24.149,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,167.4747191011236,5.14338702087321e-40,LRR concave beta-strand detector,True,assigned_and_evaluated +4377,87413,17.912874,0.6123047,Disulfide bond,keyword,87413,Disulfide bond,0.6123047,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.565115354017502,0.09331372843038009,0.0717766947275144,,1.3000560806627646,2.0,16.0,1.4784021027573895,0.6190853471572781,Surface-exposed flexible loops,True,assigned_and_evaluated +4378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic binding surfaces,False,no_term_above_threshold +4379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/interaction module,False,no_term_above_threshold +4380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA recognition alpha helices,False,no_term_above_threshold +4381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic interaction helices,False,no_term_above_threshold +4382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycan-processing ectodomains,False,no_term_above_threshold +4383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic terminal accessory regions,False,no_term_above_threshold +4384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic substrate-entry lid,False,no_term_above_threshold +4385,36776,16.054506,0.9892578,SANT/Myb domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9321289,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9840071079520214,0.08453013291090175,0.002658396101019052,,31.797418329984207,0.0,20.0,0.0,1.0,HTH-flanking packing helix,True,assigned_and_evaluated +4386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-domain interfaces,False,no_term_above_threshold +4387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S1 sulfatase catalytic core,False,no_term_above_threshold +4388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-adjacent beta/alpha core,False,no_term_above_threshold +4389,82029,31.781208,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,17.0,188.0788643533123,1.0133225259294918e-38,MFS helix-loop junctions,True,assigned_too_few_test_positives +4390,63831,16.14394,0.6723633,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.6723633,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.4811195024433585,0.002658396101019052,0.002658396101019052,,1.0,0.0,15.0,0.0,1.0,Tyrosine beta-strand edge motif,True,assigned_and_evaluated +4391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered C-terminal tails,False,no_term_above_threshold +4392,83419,17.88504,0.9667969,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9609375,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,2.0,17.0,42.76972740315638,0.0017506281644274655,Carbohydrate-binding beta-strand motif,True,assigned_too_few_test_positives +4393,64085,15.600337,0.7836914,WD40-repeat-containing domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.67041016,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9031356149458438,0.06558644930808633,0.012405848471422242,,5.2867362888696725,0.0,17.0,0.0,1.0,Hydrophobic helix-loop capping motif,True,assigned_and_evaluated +4394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp phosphate-binding patch,False,no_term_above_threshold +4395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane anchors and beta-barrel signals,False,no_term_above_threshold +4396,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory interface/lid segments,False,no_term_above_threshold +4397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary caps,False,no_term_above_threshold +4398,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered tracts,False,no_term_above_threshold +4399,36886,16.33103,0.70703125,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.70703125,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.7407180969319698,0.05185162914671111,0.003544528134692069,,14.628640873015872,0.0,15.0,0.0,1.0,Post-cleavage N-terminal structuring,True,assigned_and_evaluated +4400,64148,31.275414,0.90234375,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.86865234,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9673815907059874,0.615040830967618,0.008418254319893664,0.7894736842105263,73.06037660494283,5.0,19.0,23.417517674783973,3.438563078258042e-06,Short acidic leucine-rich amphipathic helix,True,assigned_and_evaluated +4401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-binding and catalytic hotspots,False,no_term_above_threshold +4402,64058,17.05417,0.63671875,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.63671875,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8890516527609706,0.49695968079769703,0.006202924235711121,0.35714285714285715,80.11699996860015,11.0,15.0,83.59859783301465,7.285652682769229e-20,Non-Rossmann oxidoreductase catalytic subdomain,True,assigned_and_evaluated +4403,-1,,,,,-1,,,0,,,,,,,,,,,,,,,2H phosphoesterase oxyanion pocket,False,no_term_above_threshold +4404,87697,19.547188,0.88916016,Knottin,keyword,87413,Disulfide bond,0.6660156,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9665845876395921,0.2137380998629469,0.017279574656623838,,12.36940747155567,0.0,16.0,0.0,1.0,Exposed secondary structure boundaries,True,assigned_and_evaluated +4405,37291,20.648191,0.9760742,DnaJ domain,interpro,64599,Chaperone J-domain superfamily,0.9609375,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,0.0,13.0,0.0,1.0,PIPK catalytic domain activation,True,assigned_too_few_test_positives +4406,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Second shell active site lining,False,no_term_above_threshold +4407,64058,20.67433,0.8828125,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.8828125,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8899751608177824,0.038023680665668746,0.006202924235711121,,6.129960518743883,1.0,17.0,6.705769879653582,0.2218196918107203,N-terminal beta1 starter segment,True,assigned_and_evaluated +4408,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PheRSβ phosphate and nucleic-acid interfaces,False,no_term_above_threshold +4409,28025,22.536488,0.9301758,GTPase activity,go_mf,29034,GTP binding,0.7841797,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.998963423663557,0.6097582972582972,0.002658396101019052,1.0,229.37074615199612,10.0,13.0,208.46503496503496,2.978922091798531e-22,GTPase Walker A P-loop,True,assigned_and_evaluated +4410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic HTH/WH entry helix,False,no_term_above_threshold +4411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helices with conserved hotspots,False,no_term_above_threshold +4412,85649,30.579514,0.8911133,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8876953,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8425907905492195,0.49453486998517104,0.0101905183872397,0.6521739130434783,48.52892180680569,10.0,10.0,110.61410018552876,8.921806865984403e-21,Active-site gating segments,True,assigned_and_evaluated +4413,45290,18.818386,0.90722656,Protein kinase-like domain superfamily,interpro,87855,Nucleotide-binding,0.72998047,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9264705882352942,0.08050899817421987,0.0057598582188746125,,13.977600683016481,0.0,13.0,0.0,1.0,Acidic-glycine active-site micro-motifs,True,assigned_and_evaluated +4414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane beta-barrel loop signature,False,no_term_above_threshold +4415,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory interaction domains,False,no_term_above_threshold +4416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extracellular beta-rich segment,False,no_term_above_threshold +4417,82029,22.52247,0.99609375,MFS general substrate transporter like domains,gene3d,63831,F-box-like domain superfamily,0.9658203,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,Transmembrane helix boundary caps,True,assigned_too_few_test_positives +4418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Patatin-like phospholipase domain,False,no_term_above_threshold +4419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane capping helices,False,no_term_above_threshold +4420,64475,15.938286,0.8574219,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.83740234,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.8823186617304264,0.6881160953637226,0.0057598582188746125,0.6153846153846154,119.46754055660938,6.0,16.0,199.62388392857142,6.731830686309594e-13,NR-PKS Product Template domain,True,assigned_and_evaluated +4421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide/phosphate-binding catalytic sites,False,no_term_above_threshold +4422,63774,15.954476,0.83691406,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.83691406,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,17.0,0.0,1.0,Spliceosomal regulatory IDRs,True,assigned_too_few_test_positives +4423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical RNA-binding interfaces,False,no_term_above_threshold +4424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta-strand motif,False,no_term_above_threshold +4425,64026,17.175514,0.8701172,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.71484375,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9276617799496519,0.023349146629939213,0.002658396101019052,,8.783170657295466,0.0,16.0,0.0,1.0,Transmembrane helix boundary motifs,True,assigned_and_evaluated +4426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Heme peroxidase/dioxygenase catalytic domains,False,no_term_above_threshold +4427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic C-terminal beta-strands,False,no_term_above_threshold +4428,31094,16.640696,0.9272461,phosphopantetheine binding,go_mf,43643,Phosphopantetheine binding ACP domain,0.78808594,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.8970627503337784,0.29310132696945623,0.004430660168365086,,66.15296949700628,0.0,18.0,0.0,1.0,Extracytoplasmic catalytic regions,True,assigned_and_evaluated +4429,88153,17.311192,0.66015625,Transferase,keyword,87601,Hydrolase,0.6538086,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8317814497173986,0.21268745367653438,0.052724856003544526,,4.033912461747379,3.0,15.0,2.269115128449096,0.2235763603679368,Active-site amphipathic helices,True,assigned_and_evaluated +4430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic secondary-structure boundaries,False,no_term_above_threshold +4431,37071,24.39529,0.83154297,Homeodomain,interpro,37071,Homeodomain,0.83154297,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,20.0,0.0,1.0,Surface-exposed low-complexity loops,True,assigned_too_few_test_positives +4432,36914,21.02362,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,16.0,736.0617283950618,7.329763891109132e-46,Nucleotide-sugar donor-binding patch,True,assigned_too_few_test_positives +4433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MYRF motif and tail-spike,False,no_term_above_threshold +4434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SecD/SecF periplasmic head activation,False,no_term_above_threshold +4435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TPS glycosyltransferase with PEST-like IDRs,False,no_term_above_threshold +4436,64146,17.542368,0.61083984,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.61083984,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.5116867649248177,0.009447831098481184,0.007975188303057155,,1.1846530438484462,6.0,18.0,22.279895366218234,3.4376830657705846e-07,N-terminal structured binding patches,True,assigned_and_evaluated +4437,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-component histidine kinase core,False,no_term_above_threshold +4438,38317,15.906311,0.81933594,Pentatricopeptide repeat,interpro,87326,Coiled coil,0.6123047,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8472698412698414,0.08389839754593853,0.0031014621178555605,,27.05124046588332,0.0,20.0,0.0,1.0,Coiled-coil heptad face,True,assigned_and_evaluated +4439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Hydrophobic TM helix, GS-rich tail",False,no_term_above_threshold +4440,10369,23.674345,0.7836914,DNA integration,go_bp,88163,Transposable element,0.6557617,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,8.0,15.0,291.7235474006116,1.5287199479126492e-18,Integrase/transposase catalytic DNA-binding regions,True,assigned_too_few_test_positives +4441,49236,19.111908,0.89404297,C-type lectin fold,interpro,49236,C-type lectin fold,0.89404297,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9942273534635879,0.18208791208791208,0.002215330084182543,,82.19448351648352,0.0,19.0,0.0,1.0,Short linear acidic patches,True,assigned_and_evaluated +4442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mitochondrial inner membrane import helices,False,no_term_above_threshold +4443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved micro-motifs and TM helices,False,no_term_above_threshold +4444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoskeletal coiled-coil stalks,False,no_term_above_threshold +4445,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted β-sheet ectodomains,False,no_term_above_threshold +4446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity activation regions,False,no_term_above_threshold +4447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic amphipathic helical interaction patch,False,no_term_above_threshold +4448,59211,19.134035,0.9243164,Nucleotide-diphospho-sugar transferases,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7885742,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9974551971326164,0.8184630458288513,0.011076650420912717,1.0,73.8908437774287,16.0,16.0,244.34836065573774,2.609530204638983e-38,Basic nucleotide phosphate-binding loop,True,assigned_and_evaluated +4449,48241,21.468426,0.89941406,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.89941406,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,18.0,18.0,387.14935064935065,2.6960306916448084e-46,Cupin/DSBH aromatic motif hotspots,True,assigned_too_few_test_positives +4450,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic membrane interface segments,False,no_term_above_threshold +4451,85664,15.892537,0.9790039,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.87158203,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,16.0,16.0,331.22777777777776,2.1521342125337958e-40,GT donor-binding helices,True,assigned_too_few_test_positives +4452,49116,22.704653,0.9633789,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9633789,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.997158081705151,0.40191981931112364,0.002215330084182543,0.4,181.42660643704122,14.0,20.0,60.926569343065694,6.288806491154213e-23,HEAT/ARM alpha-solenoid repeats,True,assigned_and_evaluated +4453,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase catalytic loops,False,no_term_above_threshold +4454,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix capping motifs,False,no_term_above_threshold +4455,85664,16.37838,0.9765625,Glycogen Phosphorylase B;,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.88671875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycosyltransferase Rossmann beta-strand motif,True,assigned_too_few_test_positives +4456,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich disordered scaffolds,False,no_term_above_threshold +4457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic substrate-binding cleft,False,no_term_above_threshold +4458,48241,19.538364,0.9482422,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9482422,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,9.0,16.0,217.77150974025975,1.1710055204928766e-19,Cupin DSBH active-site beta-strand,True,assigned_too_few_test_positives +4459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal substrate-binding helix,False,no_term_above_threshold +4460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic TM juxtamembrane signature,False,no_term_above_threshold +4461,82029,15.782016,0.8461914,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.70703125,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Juxtamembrane helices and loops,True,assigned_too_few_test_positives +4462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted CAZyme catalytic cores,False,no_term_above_threshold +4463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sliding clamps with AroA/MurA cross-activation,False,no_term_above_threshold +4464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PRPP-associated nucleotide enzymes,False,no_term_above_threshold +4465,37894,15.684581,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8144531,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,8.0,709.7738095238095,3.1343957826349425e-23,SDR signature motifs,True,assigned_too_few_test_positives +4466,87539,15.710547,0.89453125,Helicase,keyword,58239,P-loop containing nucleoside triphosphate hydrolase,0.72558594,81,keywords,Helicase,keyword:keywords:Helicase,6.0,2257.0,0.7434103361468976,0.1402180869393984,0.002658396101019052,0.16666666666666666,52.74537037037037,10.0,15.0,105.43059239610963,6.678868202352335e-19,SF2 Hel1 motif II–Arch activation,True,assigned_and_evaluated +4467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBP60 motif and C-terminal extensions,False,no_term_above_threshold +4468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane and helical scaffold marker,False,no_term_above_threshold +4469,85682,23.08227,0.92333984,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.92333984,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9853494623655914,0.3665601433136655,0.011076650420912717,0.16,33.09304973835772,1.0,15.0,6.817724413950828,0.21862323143570717,Cofactor-binding beta-alpha junction loops,True,assigned_and_evaluated +4470,37341,19.185831,0.99902344,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9941406,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 GH-dipeptide marker,True,assigned_and_evaluated +4471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multivalent IDR-helical scaffolds,False,no_term_above_threshold +4472,81858,16.386557,0.8930664,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.70410156,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Juxtamembrane interfacial motifs,True,assigned_too_few_test_positives +4473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-component TM and receiver,False,no_term_above_threshold +4474,45804,20.736048,0.7915039,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.76220703,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,17.0,18.0,260.6885288065844,2.664816531031812e-40,Transporter C-terminal helix bundle,True,assigned_too_few_test_positives +4475,85664,17.325777,0.78222656,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.78222656,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,RNA 3′-tailing NTase core,True,assigned_too_few_test_positives +4476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal structured domain cores,False,no_term_above_threshold +4477,47529,16.207413,0.6801758,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6801758,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.730979473449353,0.06208564654452315,0.007089056269384138,,8.757956515686796,0.0,18.0,0.0,1.0,Aromatic S/T/G disulfide anchoring microloops,True,assigned_and_evaluated +4478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma70 region 2.2 helix,False,no_term_above_threshold +4479,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal prodomains/assembly regions,False,no_term_above_threshold +4480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory metallopeptidase-like ectodomains,False,no_term_above_threshold +4481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cu/Zn SOD fold and CCS,False,no_term_above_threshold +4482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal heme-handling domain activation,False,no_term_above_threshold +4483,50869,15.651254,0.9995117,"DNA binding HTH domain, AraC-type",interpro,88263,Zinc-finger,0.8208008,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,17.0,0.0,1.0,C2H2 recognition helix residues,True,assigned_too_few_test_positives +4484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear polyelectrolyte IDRs,False,no_term_above_threshold +4485,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +4486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil hinge loops,False,no_term_above_threshold +4487,64146,17.818033,0.8198242,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8198242,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8926728202074339,0.03929565261778459,0.007975188303057155,,4.927238219907768,0.0,16.0,0.0,1.0,Sparse internal residue peaks,True,assigned_and_evaluated +4488,37430,16.056421,1.0,"Signal transduction response regulator, receiver domain",interpro,64016,Thioredoxin-like superfamily,0.7597656,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,13.0,13.0,484.7235772357723,3.356316449351675e-35,Two-component phosphotransfer interface,True,assigned_too_few_test_positives +4489,46078,19.394642,0.9326172,Armadillo-like helical,interpro,82597,Tetratricopeptide repeat domain,0.8652344,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,5.0,20.0,32.686951754385966,7.019065540626004e-07,Helix-capping loop motifs,True,assigned_too_few_test_positives +4490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small protein interface hotspots,False,no_term_above_threshold +4491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich C-terminal tails,False,no_term_above_threshold +4492,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich acidic surface loops,False,no_term_above_threshold +4493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal module,False,no_term_above_threshold +4494,46078,24.784464,0.9472656,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9321289,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,7.0,20.0,45.761732456140344,2.1823090731644766e-10,Amphipathic HEAT-like helical scaffolds,True,assigned_too_few_test_positives +4495,87274,15.836154,0.6738281,Cell inner membrane,keyword,88161,Transmembrane helix,0.64501953,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.8564587872185911,0.43195247263480163,0.0358883473637572,0.7037037037037037,12.036009021441325,11.0,14.0,30.637718396711204,2.4303938301981715e-15,Amphipathic TM boundary helices,True,assigned_and_evaluated +4496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like low-complexity IDRs,False,no_term_above_threshold +4497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,REC domain α4 helix,False,no_term_above_threshold +4498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,uL2/bL27 ribosomal motif sensor,False,no_term_above_threshold +4499,50869,15.924462,0.8925781,"DNA binding HTH domain, AraC-type",interpro,80926,Homeodomain-like,0.6201172,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,8.0,18.0,407.6649572649572,1.421538557243851e-19,N-terminal regulatory activation segments,True,assigned_too_few_test_positives +4500,36876,15.803348,0.83691406,Cytochrome P450,interpro,36876,Cytochrome P450,0.83691406,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.7742190589165678,0.12633304279479143,0.003987594151528578,,31.681519731982696,0.0,9.0,0.0,1.0,Acidic coiled-coil transducer stalks,True,assigned_and_evaluated +4501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TrpCF IGPS C-terminal motif,False,no_term_above_threshold +4502,87276,34.146538,0.67529297,Cell membrane,keyword,88161,Transmembrane helix,0.64746094,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7982327916648461,0.5231654812770994,0.11120957022596367,0.6573705179282868,4.704320682240691,11.0,15.0,6.017350215616111,1.4694290198986936e-07,Gly/Ala-rich TM helix packing,True,assigned_and_evaluated +4503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity termini,False,no_term_above_threshold +4504,88150,19.917643,0.6347656,Transcription regulation,keyword,88150,Transcription regulation,0.6347656,1201,keywords,Transcription regulation,keyword:keywords:Transcription regulation,122.0,2257.0,0.6457211962989979,0.16709864639856628,0.05405405405405406,0.04918032786885246,3.091324958373476,10.0,19.0,6.294779074064298,1.4516649566538285e-06,Ser/Thr-rich low-complexity IDRs,True,assigned_and_evaluated +4505,83032,17.479168,0.88623047,SH3 Domains,gene3d,83032,SH3 Domains,0.88623047,34,gene3d,2.30.30.40,gene3d:gene3d:2.30.30.40,6.0,2257.0,0.999629794165556,0.8178571428571427,0.002658396101019052,1.0,307.65059523809515,11.0,17.0,190.04085772239932,1.8923672303608237e-23,SH3 C-terminus and disordered linkers,True,assigned_and_evaluated +4506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured domain functional hotspots,False,no_term_above_threshold +4507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase catalytic core,False,no_term_above_threshold +4508,36776,17.275503,0.97558594,SANT/Myb domain,interpro,87384,DNA-binding,0.6796875,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9861172812083518,0.09586810994327283,0.002658396101019052,,36.062387356994456,0.0,17.0,0.0,1.0,Mature N-terminal subdomain activation,True,assigned_and_evaluated +4509,64148,17.337866,0.6791992,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6767578,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8012205446592352,0.3293976085553073,0.008418254319893664,0.3684210526315789,39.12896855312256,6.0,16.0,33.36996268656716,2.8706161964619564e-08,Transcription factor DNA-binding helices,True,assigned_and_evaluated +4510,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic N-terminal scaffolds,False,no_term_above_threshold +4511,64058,38.88677,0.94091797,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9355469,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9931055346793198,0.4227816668255636,0.006202924235711121,0.14285714285714285,68.15844443037837,12.0,12.0,113.99808795411089,5.5316230116267185e-25,Rossmann cofactor-binding loop,True,assigned_and_evaluated +4512,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic domain activation,False,no_term_above_threshold +4513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DExD/H helicase ATPase core,False,no_term_above_threshold +4514,85649,23.13901,0.6821289,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6791992,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6057179557043323,0.22536649265088324,0.0101905183872397,0.21739130434782608,22.115311909262758,16.0,17.0,104.1073884099094,1.1224901276229488e-31,SAM MTase Rossmann-core loop,True,assigned_and_evaluated +4515,85672,26.313696,0.7104492,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.70996094,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6437353044174297,0.18746861967545803,0.01595037660611431,0.25,11.753240961319689,17.0,17.0,40.01409395973155,1.7557395315514075e-27,SF1/SF2 HELICc beta-strand,True,assigned_and_evaluated +4516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoenzyme sugar-binding segments,False,no_term_above_threshold +4517,45714,19.087158,0.8774414,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.8774414,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,9.0,0.0,1.0,HAMP exit coiled-coil linkers,True,assigned_too_few_test_positives +4518,85649,15.7366,0.8442383,Vaccinia Virus protein VP39,gene3d,88153,Transferase,0.66552734,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.878566424039547,0.05826700631260762,0.0101905183872397,,5.717766662937191,0.0,18.0,0.0,1.0,IPMDH beta-strand positional signal,True,assigned_and_evaluated +4519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine helix-cap hinge,False,no_term_above_threshold +4520,49121,15.852621,0.8647461,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.8647461,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,11.0,17.0,632.4310511089683,2.2308074525617154e-29,OmpR/PhoB winged-helix DNA-binding,True,assigned_too_few_test_positives +4521,82029,18.515306,0.8730469,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6791992,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,14.0,0.0,1.0,Hydrophobic transmembrane helix cores,True,assigned_too_few_test_positives +4522,38873,20.419262,0.96972656,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8779297,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9944493783303731,0.4373015873015873,0.002215330084182543,0.4,197.39793650793652,13.0,14.0,159.08723316912972,3.4776660445681377e-28,AAA+ pore-loop hairpin,True,assigned_and_evaluated +4523,64148,25.00586,0.80566406,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7675781,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8498424345044918,0.446625828482038,0.008418254319893664,0.3684210526315789,53.05444709915578,9.0,18.0,44.49328358208955,2.7011143103027946e-13,Central effector-binding core,True,assigned_and_evaluated +4524,27918,18.603802,0.6142578,DNA-binding transcription factor activity,go_mf,27918,DNA-binding transcription factor activity,0.6142578,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.5862616066104438,0.13054799530209366,0.00930438635356668,0.19047619047619047,14.030801209372639,13.0,13.0,37.008690254500316,1.0345399949928525e-20,Plant TF C-terminal IDRs,True,assigned_and_evaluated +4525,36010,15.886121,0.86376953,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.79296875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,1.0,15.0,33.97207977207977,0.04842082342563835,Pre-catalytic N-terminal activation,True,assigned_too_few_test_positives +4526,36499,16.273373,0.9765625,"Zinc finger, GATA-type",interpro,27918,DNA-binding transcription factor activity,0.6464844,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,1.0,11.0,69.48834498834499,0.024225265764407734,Plant transcriptional IDR activation regions,True,assigned_too_few_test_positives +4527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cavity-lining TM gate helices,False,no_term_above_threshold +4528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen G-X-Y repeat detector,False,no_term_above_threshold +4529,37430,15.702325,0.9995117,"Signal transduction response regulator, receiver domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6875,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,18.0,18.0,484.7235772357723,5.774267819403017e-48,REC α1 acidic motif,True,assigned_too_few_test_positives +4530,59224,33.672775,0.97998047,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97998047,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,20.0,20.0,137.37557603686636,1.3818410501239142e-42,Alpha/beta-hydrolase catalytic acid loop,True,assigned_and_evaluated +4531,36499,20.199461,0.9008789,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.9008789,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,13.0,0.0,1.0,BRCT-domain interaction modules,True,assigned_too_few_test_positives +4532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Luminal acceptor-binding loop,False,no_term_above_threshold +4533,45804,16.86274,0.9370117,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.7441406,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,18.0,0.0,1.0,Positive-inside interface anchor,True,assigned_too_few_test_positives +4534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix residues,False,no_term_above_threshold +4535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Pro/Ser-rich regulatory IDRs,False,no_term_above_threshold +4536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Complex I subunit C,False,no_term_above_threshold +4537,48767,23.348686,1.0,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,1.0,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,15.0,15.0,931.5781249999999,9.593060343928975e-45,"ARF/B3 activated, PB1 suppressed",True,assigned_too_few_test_positives +4538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular solvent-exposed interaction domains,False,no_term_above_threshold +4539,50869,20.79415,0.9995117,"DNA binding HTH domain, AraC-type",interpro,88263,Zinc-finger,0.7944336,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,17.0,0.0,1.0,C2H2 φ–x2–H helix motif,True,assigned_too_few_test_positives +4540,50807,16.233223,0.9941406,"Cytochrome P450, conserved site",interpro,36876,Cytochrome P450,0.96875,26,ip,IPR017972,interpro:ip:IPR017972,8.0,2257.0,0.9998888394842153,0.9704861111111112,0.003544528134692069,1.0,273.79839409722223,0.0,13.0,0.0,1.0,Catalytic glycine and disordered motifs,True,assigned_and_evaluated +4541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,α-Helical hydrophobe sensor,False,no_term_above_threshold +4542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helices and beta-strands,False,no_term_above_threshold +4543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD C-terminal accessory subdomain,False,no_term_above_threshold +4544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping loops,False,no_term_above_threshold +4545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CRISPR RAMP RNA-binding signature,False,no_term_above_threshold +4546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-lined catalytic loops/β-strands,False,no_term_above_threshold +4547,87276,31.721668,0.6176758,Cell membrane,keyword,88161,Transmembrane helix,0.6015625,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.570813456046204,0.19845935912130452,0.11120957022596367,0.1553784860557769,1.7845528826166706,15.0,19.0,6.47800860532835,9.72345638327814e-11,TM-flanking amphipathic loops/tails,True,assigned_and_evaluated +4548,85682,18.183369,0.80615234,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.80615234,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.941084229390681,0.5251035469284095,0.011076650420912717,0.76,47.40634821669681,0.0,16.0,0.0,1.0,Cofactor phosphate-binding loops,True,assigned_and_evaluated +4549,38873,18.131283,0.87158203,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7109375,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8954262877442273,0.5225209880947586,0.002215330084182543,0.4,235.86597402597403,11.0,11.0,171.32471264367817,6.880872708632078e-25,ABC NBD Walker B motif,True,assigned_and_evaluated +4550,81858,17.481915,0.734375,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.734375,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane helix packing signatures,True,assigned_too_few_test_positives +4551,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavin-dependent oxidoreductase core,False,no_term_above_threshold +4552,37894,18.827227,0.9902344,Short-chain dehydrogenase/reductase SDR,interpro,45290,Protein kinase-like domain superfamily,0.9682617,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,13.0,0.0,1.0,Catalytic loop HxD+1 hydrophobe,True,assigned_too_few_test_positives +4553,39971,19.20052,0.9536133,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,39971,"Calcineurin-like phosphoesterase domain, ApaH type",0.9536133,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,19.0,0.0,1.0,SGNH cap-loop O-acetyl enzymes,True,assigned_too_few_test_positives +4554,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CRISPR RAMP RNA-binding groove,False,no_term_above_threshold +4555,59211,18.00814,0.9892578,Nucleotide-diphospho-sugar transferases,interpro,88153,Transferase,0.6328125,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9996415770609319,0.9440205969723133,0.011076650420912717,1.0,85.22617949466044,19.0,19.0,244.34836065573774,4.317107890414195e-45,Glycosyltransferase DxD metal-binding loop,True,assigned_and_evaluated +4556,64507,15.801266,0.90625,Ankyrin repeat-containing domain superfamily,interpro,88009,Repeat,0.6767578,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9322113483590352,0.03636268749721649,0.003987594151528578,,9.118953964579735,1.0,20.0,8.257756232686981,0.18421690194614956,Generic hydrophobic core packing,True,assigned_and_evaluated +4557,87489,18.978374,0.6635742,GPI-anchor,keyword,87489,GPI-anchor,0.6635742,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8517460317460318,0.1926443737919148,0.0031014621178555605,,62.114050235478814,3.0,20.0,22.08185185185185,0.0005820446848073517,Threonine-centered anchoring motifs,True,assigned_and_evaluated +4558,87326,17.84057,0.6386719,Coiled coil,keyword,87326,Coiled coil,0.6386719,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6878912890252499,0.08461299927687048,0.03943287549844927,,2.145747633347154,7.0,18.0,4.902927562792228,0.0005121872646802977,Cytosolic coiled-coil scaffolds,True,assigned_and_evaluated +4559,36272,15.660695,0.99853516,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.99853516,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,14.0,0.0,1.0,Anionic cofactor-binding cores,True,assigned_too_few_test_positives +4560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich loops,False,no_term_above_threshold +4561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pan-protein C-terminal-biased activation,False,no_term_above_threshold +4562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Formin autoinhibitory DAD tail,False,no_term_above_threshold +4563,49116,22.25999,0.9301758,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9301758,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9928063943161634,0.4123195084485407,0.002215330084182543,0.4,186.1210261136713,17.0,19.0,77.87606607760277,5.794773518017764e-31,HEAT/ARM alpha-solenoid IDR activation,True,assigned_and_evaluated +4564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic substrate-binding residues,False,no_term_above_threshold +4565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coils and tails,False,no_term_above_threshold +4566,37894,21.336458,0.84277344,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.84277344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,3.0,15.0,141.9547619047619,2.323912125495433e-06,Conserved catalytic cofactor-binding motifs,True,assigned_too_few_test_positives +4567,46277,19.254457,0.96972656,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.96972656,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9806524730834616,0.2180947053027142,0.004873726185201595,,44.74906816983872,1.0,15.0,12.538590956887486,0.12529410049825102,Acidic glycine beta-strand edge motif,True,assigned_and_evaluated +4568,37640,24.59977,0.9975586,EF-hand domain,interpro,46081,EF-hand domain pair,0.9921875,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,15.0,20.0,224.70226130653268,2.9223115496829985e-33,EF-hand/EH Ca2+ sensing,True,assigned_too_few_test_positives +4569,81685,23.322374,0.9692383,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96728516,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9571083890126206,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,19.0,19.0,85.66235632183908,8.858414841848649e-37,DFG-like activation-loop triad,True,assigned_and_evaluated +4570,36499,31.654821,0.9404297,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.9404297,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,15.0,0.0,1.0,Mago nashi strand-helix interface,True,assigned_too_few_test_positives +4571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted hydrolase catalytic domains,False,no_term_above_threshold +4572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity tails,False,no_term_above_threshold +4573,37468,18.128824,0.9609375,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.90625,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,19.0,0.0,1.0,Basic disordered microdomains,True,assigned_too_few_test_positives +4574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter cytosolic regulatory extensions,False,no_term_above_threshold +4575,87326,29.187983,0.6538086,Coiled coil,keyword,87326,Coiled coil,0.6538086,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6570442389817156,0.1463248177084938,0.03943287549844927,0.10112359550561797,3.7107316131243877,5.0,18.0,3.502091116280163,0.019035319660677688,Coiled-coil oligomerization scaffolds,True,assigned_and_evaluated +4576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane glycan/lipid transferases; redox/metal motifs,False,no_term_above_threshold +4577,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic accessory domains,False,no_term_above_threshold +4578,49116,23.831038,0.9638672,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9638672,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9985790408525755,0.6579365079365079,0.002215330084182543,0.4,296.9925396825397,16.0,20.0,69.63036496350365,1.2077902373367953e-27,Alpha-solenoid helix-capping linkers,True,assigned_and_evaluated +4579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic polar disordered tails,False,no_term_above_threshold +4580,36449,19.91017,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,7.0,19.0,392.24342105263156,5.310348473217718e-17,Membrane-interface helix-loop junctions,True,assigned_too_few_test_positives +4581,38317,17.68621,0.73779297,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.73779297,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6356190476190476,0.029488057356909812,0.0031014621178555605,,9.507792207792207,0.0,20.0,0.0,1.0,Disordered low-complexity C-terminal tails,True,assigned_and_evaluated +4582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ThDP PP-domain loop,False,no_term_above_threshold +4583,63951,19.132362,0.9814453,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.90185547,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9987643337287465,0.6410594035594036,0.003987594151528578,1.0,160.76345264817488,18.0,18.0,161.13783783783785,1.0016010608753668e-39,Ig/FN3 loop-edge segments,True,assigned_and_evaluated +4584,64058,32.38728,0.74902344,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7441406,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7482166740971913,0.35498638275277616,0.006202924235711121,0.42857142857142855,57.22887613378684,17.0,17.0,113.99808795411089,4.31985177778818e-35,NAD(P)-binding Rossmann subdomain,True,assigned_and_evaluated +4585,48767,16.674616,0.9814453,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.92089844,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,16.0,0.0,1.0,Flexible C-terminal interaction tails,True,assigned_too_few_test_positives +4586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,STING-like c-di-GMP sensor,False,no_term_above_threshold +4587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic nucleic acid-binding lobes,False,no_term_above_threshold +4588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich pocket hinge loops,False,no_term_above_threshold +4589,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OM beta-barrel periplasmic starts,False,no_term_above_threshold +4590,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GST H-site α4 helix,False,no_term_above_threshold +4591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal stalks near first TM,False,no_term_above_threshold +4592,37020,15.809222,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,17.0,816.7260273972603,3.4794486095487155e-49,Glycosyltransferase core hydrophobic beta strand,True,assigned_too_few_test_positives +4593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase ATP-lid helix,False,no_term_above_threshold +4594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrophobic contact motif,False,no_term_above_threshold +4595,29104,17.236094,0.81689453,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.63964844,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,13.0,0.0,1.0,Transmembrane helix-coil boundaries,True,assigned_too_few_test_positives +4596,36776,15.923837,0.9692383,SANT/Myb domain,interpro,87384,DNA-binding,0.6767578,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9749740855915889,0.05553006387208538,0.002658396101019052,,20.888559026549448,0.0,17.0,0.0,1.0,Basic N-terminal starter helix,True,assigned_and_evaluated +4597,87697,17.89264,0.8300781,Knottin,keyword,88058,Signal,0.68603516,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7771207602136367,0.20930872106072856,0.017279574656623838,,12.113071370104214,6.0,18.0,84.21045197740114,1.359424136112723e-10,N-terminal Sec signal peptide,True,assigned_and_evaluated +4598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding active-site loops,False,no_term_above_threshold +4599,36104,20.69766,0.92626953,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.9145508,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,10.0,0.0,1.0,Metallocarboxypeptidase M14 catalytic core,True,assigned_too_few_test_positives +4600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenyl/lipid-phosphate membrane enzymes/transporters,False,no_term_above_threshold +4601,50779,17.906605,0.9946289,Myb domain,interpro,43624,Homedomain-like superfamily,0.93603516,33,ip,IPR017930,interpro:ip:IPR017930,5.0,2257.0,0.9824156305506216,0.06842673384201624,0.002215330084182543,,30.88782765628613,0.0,17.0,0.0,1.0,Short nucleic acid recognition helices,True,assigned_and_evaluated +4602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine beta loop motif,False,no_term_above_threshold +4603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane signal-anchors and disordered linkers,False,no_term_above_threshold +4604,36914,22.378216,0.9604492,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8852539,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,14.0,15.0,686.9909465020576,2.5905481558118768e-39,Glycosyltransferase C-terminal membrane anchor,True,assigned_too_few_test_positives +4605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic proline-rich coil linkers,False,no_term_above_threshold +4606,88161,24.168364,0.62597656,Transmembrane helix,keyword,88161,Transmembrane helix,0.62597656,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6586923939109581,0.3277794459211374,0.1847585290208241,0.2422062350119904,1.774096425525197,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Transmembrane helix hydrophobic residues,True,assigned_and_evaluated +4607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic coupling segments,False,no_term_above_threshold +4608,87413,16.096182,0.609375,Disulfide bond,keyword,87413,Disulfide bond,0.609375,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.560165296561478,0.07518552537525788,0.0717766947275144,,1.0474921652589941,1.0,16.0,0.7392010513786947,1.0,BTB/POZ N-terminus beta-strand detector,True,assigned_and_evaluated +4609,38317,16.623981,0.76904297,Pentatricopeptide repeat,interpro,63774,RNA-binding domain superfamily,0.7597656,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.631968253968254,0.020137408006260467,0.0031014621178555605,,6.492875695732839,0.0,18.0,0.0,1.0,Nucleic-acid-contacting entry/coiled-coil regions,True,assigned_and_evaluated +4610,87326,21.5661,0.69921875,Coiled coil,keyword,88161,Transmembrane helix,0.6147461,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6012168829553464,0.04881552878320414,0.03943287549844927,,1.237939870378559,10.0,16.0,7.8797050116303655,9.899978222928872e-08,Coiled-coil and triple-helix marker,True,assigned_and_evaluated +4611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged alpha-helical linkers,False,no_term_above_threshold +4612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAP/LEM/HEH/SAM-adjacent basic IDRs,False,no_term_above_threshold +4613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BAR/F-BAR coiled-coil scaffold,False,no_term_above_threshold +4614,87697,25.255533,0.9560547,Knottin,keyword,87413,Disulfide bond,0.71972656,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9975376291877645,0.739533841119718,0.017279574656623838,1.0,42.79815075403086,3.0,19.0,39.88916146297949,0.00010403200642233377,Extracellular cysteine-rich minidomains,True,assigned_and_evaluated +4615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic POTRA and plug domains,False,no_term_above_threshold +4616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal mixed-charge low-complexity tails,False,no_term_above_threshold +4617,36668,16.175066,0.9379883,AMP-dependent synthetase/ligase domain,interpro,36668,AMP-dependent synthetase/ligase domain,0.9379883,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,16.0,0.0,1.0,HATPase_c F/N-box ATP-lid patch,True,assigned_too_few_test_positives +4618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme catalytic core activation,False,no_term_above_threshold +4619,81858,17.143625,0.9814453,Rhodopsin 7-helix transmembrane proteins,gene3d,88159,Transmembrane,0.61865234,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,17.0,20.0,222.27127192982454,3.3792037186190506e-38,GPCR TM3 cytosolic boundary,True,assigned_too_few_test_positives +4620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core-peaked pan-chain PPase activation,False,no_term_above_threshold +4621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-to-C-terminal biosynthetic enzyme transmembrane helices,False,no_term_above_threshold +4622,81685,21.55719,0.9667969,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.90722656,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9561989606533036,0.9101652882390587,0.005316792202038104,0.9166666666666666,171.18692129629628,14.0,14.0,85.66235632183908,2.52616524771724e-27,Kinase domain hydrophobic core,True,assigned_and_evaluated +4623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic substrate binding cleft loops,False,no_term_above_threshold +4624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF C-terminal boundary signal,False,no_term_above_threshold +4625,52236,17.664976,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98779297,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,17.0,197.0290812954395,2.448847296887054e-33,TPR helix-B C-terminal anchor,True,assigned_too_few_test_positives +4626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged DNA-binding enzyme interfaces,False,no_term_above_threshold +4627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,K+ channel selectivity filter,False,no_term_above_threshold +4628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-portal β-loop-β motifs,False,no_term_above_threshold +4629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site recognition helix,False,no_term_above_threshold +4630,38873,24.284443,0.9160156,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.68310547,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9959147424511545,0.5565606806986118,0.002215330084182543,0.4,251.23149126735336,10.0,10.0,171.32471264367817,1.12424031081604e-22,ABC D-loop switch helix,True,assigned_and_evaluated +4631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytoplasmic juxtamembrane tails,False,no_term_above_threshold +4632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory all-alpha helical bundles,False,no_term_above_threshold +4633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P/G-rich disordered loops,False,no_term_above_threshold +4634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix-loop transitions,False,no_term_above_threshold +4635,37341,19.421837,0.99560547,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9926758,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9994851353595748,0.9382845814502649,0.011962782454585734,1.0,78.43364075308325,15.0,17.0,128.30918220946913,1.4692013255782468e-30,WD/NHL beta-propeller blade detector,True,assigned_and_evaluated +4636,82764,17.18397,0.9213867,Kelch-type beta propeller,gene3d,82764,Kelch-type beta propeller,0.9213867,38,gene3d,2.120.10.80,gene3d:gene3d:2.120.10.80,,,,,,,,0.0,16.0,0.0,1.0,Propeller and Solcar repeat-edge motifs,True,assigned_too_few_test_positives +4637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inter-TM loops and tails,False,no_term_above_threshold +4638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal membrane-anchoring helix,False,no_term_above_threshold +4639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic alpha-helical packing patches,False,no_term_above_threshold +4640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved family positional signature,False,no_term_above_threshold +4641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class I SAM-MTase loop,False,no_term_above_threshold +4642,82029,29.727299,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS TM3/TM9 gating helices,True,assigned_too_few_test_positives +4643,88152,15.664359,0.69677734,Transducer,keyword,88152,Transducer,0.69677734,76,keywords,Transducer,keyword:keywords:Transducer,,,,,,,,2.0,19.0,16.42904381372279,0.011177946719728632,Juxtadomain amphipathic helices,True,assigned_too_few_test_positives +4644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-like hydrophobic secondary structures,False,no_term_above_threshold +4645,35372,15.76353,0.93359375,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.93359375,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,15.0,16.0,657.5845588235294,9.455180686344042e-42,Transporter TM helix cores,True,assigned_too_few_test_positives +4646,47529,17.349485,0.69091797,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.69091797,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.5528781793842035,0.04092514645793334,0.007089056269384138,,5.773003472222221,6.0,16.0,28.99854085603113,6.531030514217132e-08,M14 C-terminal Gly-Tyr motif,True,assigned_and_evaluated +4647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic C-terminal interaction platform,False,no_term_above_threshold +4648,36010,17.433693,0.99121094,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9506836,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,3.0,16.0,95.54647435897436,7.642762768217845e-06,Substrate access cap helix,True,assigned_too_few_test_positives +4649,37894,18.065538,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8857422,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,Cofactor-pocket Rossmann packing helix,True,assigned_too_few_test_positives +4650,36104,20.122498,0.9223633,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9223633,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Phosphate/nucleotide-binding catalytic core,True,assigned_too_few_test_positives +4651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extracytoplasmic sensory segments,False,no_term_above_threshold +4652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal flanks,False,no_term_above_threshold +4653,37341,20.962774,0.9970703,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9916992,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9998339146321209,0.9866206153243189,0.011962782454585734,1.0,82.47417514025881,15.0,19.0,114.80295250320924,3.829237218848612e-29,Beta-propeller blade-start loop,True,assigned_and_evaluated +4654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad RNA polymerase core activation,False,no_term_above_threshold +4655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular binding/inhibitor domains,False,no_term_above_threshold +4656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix-capping loops,False,no_term_above_threshold +4657,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal oligomerization cap,False,no_term_above_threshold +4658,49116,19.076815,0.8388672,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8388672,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8849911190053286,0.08464039043155223,0.002215330084182543,,38.20667224080268,1.0,20.0,4.351897810218978,0.32552345429018376,HEAT/ARM/TPR alpha-solenoid scaffolds,True,assigned_and_evaluated +4659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S-layer lattice domain,False,no_term_above_threshold +4660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-membrane soluble alpha-helix detector,False,no_term_above_threshold +4661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+ N-terminal targeting/anchoring segments,False,no_term_above_threshold +4662,85656,18.04382,0.9301758,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8017578,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.970952380952381,0.0563384409196387,0.0031014621178555605,,18.165123022232077,0.0,14.0,0.0,1.0,Conserved distal motif peaks,True,assigned_and_evaluated +4663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic-aromatic binding motif,False,no_term_above_threshold +4664,50806,27.375559,0.96533203,"Homeobox, conserved site",interpro,37071,Homeodomain,0.90527344,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,Interdomain connector helix,True,assigned_too_few_test_positives +4665,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader segment,False,no_term_above_threshold +4666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity IDRs,False,no_term_above_threshold +4667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity N-termini and small proteins,False,no_term_above_threshold +4668,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity N-terminal tails,False,no_term_above_threshold +4669,64026,16.830801,0.85058594,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.73046875,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.901525248037909,0.01459586100056594,0.002658396101019052,,5.490476379712887,0.0,18.0,0.0,1.0,N-terminal transmembrane helix detector,True,assigned_and_evaluated +4670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electrostatic helical interaction surfaces,False,no_term_above_threshold +4671,38317,27.045517,0.9667969,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9667969,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8398730158730159,0.048435606368861635,0.0031014621178555605,,15.617023367788672,0.0,19.0,0.0,1.0,Basic/aromatic active-site patch,True,assigned_and_evaluated +4672,37341,23.25377,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99902344,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999335658528484,0.9943995236587826,0.011962782454585734,1.0,83.12443425547676,19.0,19.0,145.4170731707317,5.254240088122417e-41,WD40 blade loop-to-strand marker,True,assigned_and_evaluated +4673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NA-binding SLiMs and cystine-knots,False,no_term_above_threshold +4674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long disordered polar linkers,False,no_term_above_threshold +4675,85791,15.626614,0.8095703,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.61328125,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,11.0,0.0,1.0,ABC NBD pre-Walker A site,True,assigned_too_few_test_positives +4676,88252,21.119879,0.8666992,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8251953,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.965984105620714,0.15850681558381413,0.012405848471422242,,12.776781527595304,0.0,15.0,0.0,1.0,Globular soluble-domain detector,True,assigned_and_evaluated +4677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV/GAF sensory-coupling domains,False,no_term_above_threshold +4678,37894,27.25493,0.99560547,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8569336,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,1.0,17.0,41.75140056022409,0.039689626711981424,N-terminal Rossmann NADPH-binding loop,True,assigned_too_few_test_positives +4679,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-domain catalytic hotspot,False,no_term_above_threshold +4680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TCTP N-terminal beta subdomain,False,no_term_above_threshold +4681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular NIDO domain detector,False,no_term_above_threshold +4682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16 peptidase non-catalytic loops,False,no_term_above_threshold +4683,85649,41.18161,0.91748047,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.91308594,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.866081507142579,0.5590700701757365,0.0101905183872397,0.6086956521739131,54.86178906028857,15.0,15.0,110.61410018552876,7.1622047874657735e-31,C-terminal active-site lid,True,assigned_and_evaluated +4684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane cytosolic loops and helices,False,no_term_above_threshold +4685,87276,39.680912,0.6748047,Cell membrane,keyword,88161,Transmembrane helix,0.6489258,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7801197999626618,0.5505279887089294,0.11120957022596367,0.601593625498008,4.950365221179497,12.0,15.0,6.564382053399395,6.8952842138058755e-09,Transmembrane helix-loop junctions,True,assigned_and_evaluated +4686,85664,17.351654,0.87597656,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.87597656,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,13.0,0.0,1.0,Conserved charged C-terminal helix,True,assigned_too_few_test_positives +4687,37894,17.79852,0.98828125,Short-chain dehydrogenase/reductase SDR,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.859375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,9.0,0.0,1.0,ABC NBD beta-strand H-loop residue,True,assigned_too_few_test_positives +4688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-cytosol boundary motifs,False,no_term_above_threshold +4689,36886,30.55597,0.96728516,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.96728516,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9329979991107159,0.2549870965477091,0.003544528134692069,,71.93823461352244,0.0,16.0,0.0,1.0,Amidohydrolase C-terminal cap loop,True,assigned_and_evaluated +4690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-centered metal-binding motif,False,no_term_above_threshold +4691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and transmembrane anchors,False,no_term_above_threshold +4692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WG-anchored noncatalytic surface loop,False,no_term_above_threshold +4693,82029,22.901417,0.84033203,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.8300781,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,18.0,167.1812127584998,2.0721734954194948e-34,TM1-biased multipass transporter helices,True,assigned_too_few_test_positives +4694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Propeptide-domain boundary disorder,False,no_term_above_threshold +4695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic scaffold adaptor proteins,False,no_term_above_threshold +4696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic/translocation cores,False,no_term_above_threshold +4697,82029,16.140118,0.9013672,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8808594,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane helix–loop junctions,True,assigned_too_few_test_positives +4698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SIS-like phosphosugar-recognition module,False,no_term_above_threshold +4699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix motif,False,no_term_above_threshold +4700,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTPase coupling and dimerization motifs,False,no_term_above_threshold +4701,85675,15.979455,0.8222656,"von Willebrand factor, type A domain",gene3d,85675,"von Willebrand factor, type A domain",0.8222656,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,6.0,18.0,182.32721712538225,1.3073193754891505e-12,Amphipathic metal/acidic scaffold,True,assigned_too_few_test_positives +4702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal substrate bordering loop,False,no_term_above_threshold +4703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting leaders,False,no_term_above_threshold +4704,87786,17.903685,0.68408203,Mitochondrion inner membrane,keyword,87786,Mitochondrion inner membrane,0.68408203,163,keywords,Mitochondrion inner membrane,keyword:keywords:Mitochondrion inner membrane,15.0,2257.0,0.7567053226286053,0.45697533599172946,0.00664599025254763,0.4666666666666667,68.75955555555556,10.0,11.0,79.4734737403359,9.815554374505898e-19,Disordered organellar juxtamembrane regions,True,assigned_and_evaluated +4705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix capping loops,False,no_term_above_threshold +4706,85656,24.37525,0.93603516,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.9321289,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9879365079365078,0.14144154959372351,0.0031014621178555605,,45.60479677614771,0.0,14.0,0.0,1.0,Rossmann cofactor beta strand,True,assigned_and_evaluated +4707,36914,17.491844,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Glycosyltransferase loop-to-helix N-cap motif,True,assigned_too_few_test_positives +4708,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TsaD charged coil loop,False,no_term_above_threshold +4709,72011,20.435331,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9477539,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,13.0,13.0,590.3069306930694,2.4178087537758372e-36,ANL adenylation-carrier junction motif,True,assigned_too_few_test_positives +4710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet strand activation near cysteines,False,no_term_above_threshold +4711,37430,15.596266,1.0,"Signal transduction response regulator, receiver domain",interpro,55054,HAD superfamily,0.9819336,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,20.0,20.0,484.7235772357723,1.2566775785334842e-52,Two-component di-acidic motifs,True,assigned_too_few_test_positives +4712,36104,18.159813,0.9995117,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.99365234,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,12.0,15.0,467.61568627450987,5.794773518017764e-31,SLiM-rich regulatory IDRs,True,assigned_too_few_test_positives +4713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GYF-tail basic motif,False,no_term_above_threshold +4714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophilic extracytoplasmic domains,False,no_term_above_threshold +4715,37894,17.100605,0.9970703,Short-chain dehydrogenase/reductase SDR,interpro,63774,RNA-binding domain superfamily,0.9277344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,13.0,0.0,1.0,ABC NBD β1/β2 scaffold,True,assigned_too_few_test_positives +4716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming toxins and RIPs,False,no_term_above_threshold +4717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop junctions,False,no_term_above_threshold +4718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic beta-strand N-cap motifs,False,no_term_above_threshold +4719,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/alpha-solenoid tethers,False,no_term_above_threshold +4720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal peptides and anchors,False,no_term_above_threshold +4721,25169,17.057932,0.8964844,pilus,go_cc,25167,cell outer membrane,0.7792969,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8907193605683837,0.11220666473695695,0.002215330084182543,,50.650088462262374,0.0,17.0,0.0,1.0,Cleavable N-terminal signal peptides,True,assigned_and_evaluated +4722,35372,15.852309,0.9370117,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9370117,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,12.0,19.0,443.00433436532506,5.876221095359324e-30,Positive-inside TM helix cap,True,assigned_too_few_test_positives +4723,63831,21.16595,0.95410156,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.95410156,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9330297645490893,0.021617655240447866,0.002658396101019052,,8.131841312948472,0.0,20.0,0.0,1.0,SAM-binding loop signature,True,assigned_and_evaluated +4724,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interhelical membrane interface loops,False,no_term_above_threshold +4725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prokaryotic defense nuclease/MTase catalytic cores,False,no_term_above_threshold +4726,87326,24.09994,0.6743164,Coiled coil,keyword,87326,Coiled coil,0.6743164,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6955227206766449,0.17513287729458593,0.03943287549844927,0.07865168539325842,4.4412910567851736,13.0,18.0,9.105436902328423,6.046143033298259e-11,Charged helical linker scaffolds,True,assigned_and_evaluated +4727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase RNA-binding surface,False,no_term_above_threshold +4728,50338,26.58385,0.90722656,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.7890625,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,TM helix packing interfaces,True,assigned_too_few_test_positives +4729,37430,16.68738,0.9995117,"Signal transduction response regulator, receiver domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.64501953,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,14.0,14.0,484.7235772357723,7.836327138722209e-38,REC active-site switch motif,True,assigned_too_few_test_positives +4730,36914,20.696218,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9970703,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,15.0,15.0,736.0617283950618,3.765314178842642e-43,Membrane glycosyltransferase catalytic motifs,True,assigned_too_few_test_positives +4731,87317,18.625996,0.79541016,Cleavage on pair of basic residues,keyword,88058,Signal,0.6303711,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.8654897367246764,0.07723992841798143,0.007089056269384138,,10.895657402461506,3.0,19.0,13.334053973460563,0.0024289320123341254,Secreted/periplasmic cationic low-complexity regions,True,assigned_and_evaluated +4732,81685,16.135244,0.9716797,Transferase(Phosphotransferase) domain 1,gene3d,87855,Nucleotide-binding,0.7416992,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9723830734966593,0.11063004616776438,0.005316792202038104,,20.807667850053683,0.0,16.0,0.0,1.0,Acidic active-site catalytic centers,True,assigned_and_evaluated +4733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pol I 3'-5' exonuclease motif,False,no_term_above_threshold +4734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Biased helices with His hotspots,False,no_term_above_threshold +4735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal switch interaction regions,False,no_term_above_threshold +4736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RCK-like cytosolic regulatory domains,False,no_term_above_threshold +4737,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serralysin C-terminal parichein beta-sandwich,False,no_term_above_threshold +4738,85762,16.335716,0.8730469,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.87109375,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,0.0,18.0,0.0,1.0,Active-site-adjacent beta-strands,True,assigned_too_few_test_positives +4739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal peptides/coiled-coils,False,no_term_above_threshold +4740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered loops and linkers,False,no_term_above_threshold +4741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intrinsically disordered linkers,False,no_term_above_threshold +4742,47529,24.529484,0.9667969,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9667969,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9888721552878179,0.26630900296882337,0.007089056269384138,,37.56621373128965,8.0,19.0,32.55976517168408,1.0657719479783921e-10,Extracellular beta-sandwich edge motifs,True,assigned_and_evaluated +4743,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site cap helix/linker,False,no_term_above_threshold +4744,50806,19.218073,0.8413086,"Homeobox, conserved site",interpro,80926,Homeodomain-like,0.7553711,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,DNA-contact and regulatory modules,True,assigned_too_few_test_positives +4745,63951,18.990677,0.9350586,Immunoglobulin-like domain superfamily,interpro,88058,Signal,0.6425781,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9941676551996836,0.5450857784191118,0.003987594151528578,0.6666666666666666,136.69540021021504,14.0,14.0,161.13783783783785,3.975102145623941e-31,N-terminal signal peptide h-region,True,assigned_and_evaluated +4746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early acidic-aromatic beta-edge motif,False,no_term_above_threshold +4747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Walker A/B NTP-binding loops,False,no_term_above_threshold +4748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal boundary disorder signal,False,no_term_above_threshold +4749,88058,80.38344,0.8696289,Signal,keyword,88058,Signal,0.8696289,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8941529824428528,0.5542023904405133,0.09127159946832078,0.8203883495145631,6.072013569049702,19.0,20.0,6.844706948640483,2.038363878104551e-15,Sec-dependent N-terminal signal peptide,True,assigned_and_evaluated +4750,87149,19.122955,0.6166992,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6166992,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6605300262769981,0.0908106051651768,0.012405848471422242,,7.319983423493001,0.0,15.0,0.0,1.0,Membrane fusion/pore-forming modules,True,assigned_and_evaluated +4751,46284,18.943077,0.9975586,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9975586,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,12.0,15.0,953.9360000000001,6.72835956033331e-35,N-terminal alpha/beta starter module,True,assigned_too_few_test_positives +4752,83419,19.150229,0.9765625,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9682617,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,17.0,18.0,343.3458672086721,2.6594257921519396e-42,Exposed aromatic beta-sheet patches,True,assigned_too_few_test_positives +4753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal region detector,False,no_term_above_threshold +4754,85664,19.421858,0.80908203,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.80908203,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,12.0,17.0,233.80784313725493,7.7985891119439e-27,Nucleotide-sugar donor-binding loop,True,assigned_too_few_test_positives +4755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged interaction patch,False,no_term_above_threshold +4756,37894,18.178549,0.7084961,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7084961,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,13.0,0.0,1.0,CA-domain glycine hinge loop,True,assigned_too_few_test_positives +4757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved non-catalytic beta-lactamase/PBP motifs,False,no_term_above_threshold +4758,49116,27.19087,0.9765625,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9765625,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9996447602131439,0.81,0.002215330084182543,1.0,365.63400000000007,19.0,19.0,87.03795620437957,6.605101239071875e-37,HEAT-repeat B-helix N-caps,True,assigned_and_evaluated +4759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor transmembrane helix,False,no_term_above_threshold +4760,36104,20.19609,0.98046875,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.98046875,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,20.0,0.0,1.0,Alpha-helical oligomerization interface,True,assigned_too_few_test_positives +4761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Arg-rich targeting leaders,False,no_term_above_threshold +4762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal fold-capping segment,False,no_term_above_threshold +4763,55054,30.562037,0.9873047,HAD superfamily,interpro,55054,HAD superfamily,0.9873047,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8992007104795738,0.8004430660168365,0.002215330084182543,0.8,361.32,15.0,16.0,314.01509831460675,7.033744080510038e-37,Noncatalytic C-terminal phosphatase cap,True,assigned_and_evaluated +4764,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +4765,59224,32.116665,0.9555664,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9555664,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9981587301587302,0.8025974025974025,0.0031014621178555605,0.7142857142857143,258.7803339517625,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Hydrolase catalytic histidine loop,True,assigned_and_evaluated +4766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured soluble membrane-protein domains,False,no_term_above_threshold +4767,37282,20.089386,0.9902344,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.9863281,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,0.0,16.0,0.0,1.0,Beta-solenoid turn/cap residues,True,assigned_too_few_test_positives +4768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended cytoskeletal helical rods,False,no_term_above_threshold +4769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide/phosphate ligand-binding surface,False,no_term_above_threshold +4770,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic conserved PheRS-beta sites,False,no_term_above_threshold +4771,45290,15.910165,0.8457031,Protein kinase-like domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7158203,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9523344302756066,0.19327877351794692,0.0057598582188746125,,33.55616860230817,7.0,16.0,32.12338362068966,1.7937965632221238e-09,Alpha-helical domain scaffolds,True,assigned_and_evaluated +4772,38317,18.277832,0.98095703,Pentatricopeptide repeat,interpro,88009,Repeat,0.6723633,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.971111111111111,0.07081301709755679,0.0031014621178555605,,22.83213994131224,0.0,15.0,0.0,1.0,Hydrophobic core anchor residues,True,assigned_and_evaluated +4773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping loops,False,no_term_above_threshold +4774,31094,16.742712,0.9765625,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.83935547,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9994882064975523,0.8258444333444332,0.004430660168365086,1.0,186.39308860583859,0.0,17.0,0.0,1.0,Ferredoxin-dependent sulfite/nitrite reductases,True,assigned_and_evaluated +4775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signals and disorder,False,no_term_above_threshold +4776,85656,17.265997,0.92822266,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.85253906,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9470793650793651,0.14080250062487715,0.0031014621178555605,0.14285714285714285,45.39874913004967,13.0,18.0,102.03699315429172,2.285739936115086e-24,Post-nucleophile helix peaks,True,assigned_and_evaluated +4777,88161,41.612865,0.61816406,Transmembrane helix,keyword,88161,Transmembrane helix,0.61816406,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6891786570743405,0.4726840634644661,0.1847585290208241,0.46522781774580335,2.558388324314868,11.0,11.0,5.4274920345926265,1.6633903518332707e-08,Positive-inside TM helix interface,True,assigned_and_evaluated +4778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interaction-rich C-terminal segments,False,no_term_above_threshold +4779,87489,17.302649,0.7446289,GPI-anchor,keyword,87489,GPI-anchor,0.7446289,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.562031746031746,0.03122982467244762,0.0031014621178555605,,10.06938775510204,0.0,19.0,0.0,1.0,C-terminal membrane anchor,True,assigned_and_evaluated +4780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Raf1 FE-x-TG helical motif,False,no_term_above_threshold +4781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic beta-domain polyanion binding,False,no_term_above_threshold +4782,48880,21.03673,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,69093,"ANL, N-terminal domain",0.9472656,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,13.0,13.0,484.7235772357723,3.356316449351675e-35,Aminotransferase-like PLP fold I,True,assigned_too_few_test_positives +4783,52941,19.725166,0.86035156,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.85058594,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,18.0,245.88961669092672,6.9613297944377155e-40,Glycosylated first extracellular loop,True,assigned_too_few_test_positives +4784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed loop binding motifs,False,no_term_above_threshold +4785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal hydrophobic alpha-helices,False,no_term_above_threshold +4786,63831,22.25356,0.96484375,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.96484375,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9218125277654375,0.01853069124627786,0.002658396101019052,,6.970628357141521,0.0,19.0,0.0,1.0,Adenylation-pocket helical patches,True,assigned_and_evaluated +4787,45290,31.86169,0.9711914,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9711914,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9608357328945564,0.9235199890937598,0.0057598582188746125,0.9230769230769231,160.3372781065089,19.0,19.0,73.42487684729065,1.537287712313484e-35,Kinase VAIK ATP-binding motif,True,assigned_and_evaluated +4788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-adjacent low-complexity IDRs,False,no_term_above_threshold +4789,37894,19.01833,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9658203,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,16.0,532.3303571428571,2.0010793838799247e-31,N-terminal Rossmann NAD-binding loop,True,assigned_too_few_test_positives +4790,25169,16.157236,0.8803711,pilus,go_cc,25169,pilus,0.8803711,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9833925399644761,0.1361947626841244,0.002215330084182543,,61.47831587561375,0.0,20.0,0.0,1.0,Phage tail oligomerization interfaces,True,assigned_and_evaluated +4791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Caspase-like cysteine protease core,False,no_term_above_threshold +4792,36876,16.6449,0.9116211,Cytochrome P450,interpro,87079,heme,0.8232422,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9916468960063266,0.21380555658333436,0.003987594151528578,,53.61768235650952,0.0,15.0,0.0,1.0,UPP sugar-1-P active-site motif,True,assigned_and_evaluated +4793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase-fold binding-groove loops,False,no_term_above_threshold +4794,38317,23.767859,0.9316406,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9316406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.994031746031746,0.21327246688148943,0.0031014621178555605,,68.76513682164595,0.0,20.0,0.0,1.0,RNA-binding helical repeat scaffolds,True,assigned_and_evaluated +4795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal nucleic-acid handling modules,False,no_term_above_threshold +4796,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich C-terminal extensions,False,no_term_above_threshold +4797,30332,16.764626,0.7163086,hydrolase activity,go_mf,87601,Hydrolase,0.6455078,296,go,GO:0016787,go_mf:go:GO:0016787,21.0,2257.0,0.8033691115086465,0.06682754574517391,0.00930438635356668,,7.182370035564644,0.0,16.0,0.0,1.0,Sulfatase catalytic loop motif,True,assigned_and_evaluated +4798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nudix pyrophosphate-binding pocket,False,no_term_above_threshold +4799,38317,17.171316,0.9082031,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.87890625,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8087619047619048,0.0262031353844017,0.0031014621178555605,,8.44863950894209,0.0,17.0,0.0,1.0,Hydrophobic helices and collagen repeats,True,assigned_and_evaluated +4800,72011,16.20943,0.9111328,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.8388672,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,Mur ligase catalytic core,True,assigned_too_few_test_positives +4801,64058,20.612156,0.88671875,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8676758,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.978966307878479,0.20106755739706186,0.006202924235711121,,32.414962646083474,6.0,18.0,37.9993626513703,1.515182466298478e-08,Glycosyltransferase catalytic hotspot,True,assigned_and_evaluated +4802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hepadnaviral RT polymerase domain,False,no_term_above_threshold +4803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-crystallin and beta-rich fold recognition,False,no_term_above_threshold +4804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic residue functional hotspots,False,no_term_above_threshold +4805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VFT/PBP clamshell hinge,False,no_term_above_threshold +4806,87326,40.855232,0.8076172,Coiled coil,keyword,87326,Coiled coil,0.8076172,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8424141755462498,0.3502788659885642,0.03943287549844927,0.30337078651685395,8.882914612766173,11.0,14.0,9.905914871763889,4.681303879948565e-10,Coiled-coil e/g electrostatic stripes,True,assigned_and_evaluated +4807,84152,22.917875,0.89501953,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.89501953,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,13.0,13.0,562.4622641509434,4.627751018381797e-36,Amidohydrolase catalytic core region,True,assigned_too_few_test_positives +4808,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity cytosolic tail motifs,False,no_term_above_threshold +4809,49061,31.275982,0.98046875,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98046875,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9978850221111324,0.6996336832380381,0.012405848471422242,1.0,56.39547225243757,3.0,15.0,19.77479270315091,0.0007616948078194698,Extracellular beta-repeats N-terminal activation,True,assigned_and_evaluated +4810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse conserved packing residues,False,no_term_above_threshold +4811,36535,27.051794,0.96435547,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8520508,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9489764129951046,0.8158795739533443,0.004430660168365086,0.9,184.14401984126982,17.0,17.0,89.79066265060241,2.357720211227094e-33,Conserved kinase domain dipeptide motif,True,assigned_and_evaluated +4812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic alpha-helical scaffolds,False,no_term_above_threshold +4813,72011,15.951664,0.88427734,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.85791016,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,20.0,0.0,1.0,Charge-rich non-catalytic interfaces,True,assigned_too_few_test_positives +4814,59229,21.501749,0.66552734,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.66552734,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7575610135845239,0.37842408662478,0.0101905183872397,0.5217391304347826,37.134920152701234,14.0,15.0,99.19120617944147,1.7879122929735287e-27,Nucleic-acid MTase catalytic core,True,assigned_and_evaluated +4815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short catalytic active-site loops,False,no_term_above_threshold +4816,47529,15.821556,0.6850586,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6850586,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6125055778670236,0.09838307276831867,0.007089056269384138,0.125,13.878162202380953,0.0,9.0,0.0,1.0,Collagen Gly-X-Y X-position detector,True,assigned_and_evaluated +4817,47529,27.366516,0.97265625,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.97265625,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9933483935742973,0.6320771366002258,0.007089056269384138,0.625,89.16238108166935,14.0,17.0,63.683070115205616,6.264155816596203e-24,Extracellular beta-sandwich domains,True,assigned_and_evaluated +4818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-pass membrane anchor helix,False,no_term_above_threshold +4819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +4820,45551,18.201,0.83935547,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.83935547,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,2.0,9.0,75.70920634920634,0.0005449940100432572,N-terminal disordered regulatory leaders,True,assigned_too_few_test_positives +4821,10369,16.890306,0.7441406,DNA integration,go_bp,10369,DNA integration,0.7441406,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,3.0,16.0,102.55905963302752,6.184573196274229e-06,Aromatic motif and loop hotspots,True,assigned_too_few_test_positives +4822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal aromatic-belt signal-anchor helix,False,no_term_above_threshold +4823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic PEST-like IDRs,False,no_term_above_threshold +4824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bridge-like lipid-transfer scaffolds,False,no_term_above_threshold +4825,36876,15.88178,0.9199219,Cytochrome P450,interpro,87079,heme,0.82958984,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9396994859628311,0.2876264945046128,0.003987594151528578,,72.13033312187902,0.0,16.0,0.0,1.0,Beta-lactamase fold transpeptidase core,True,assigned_and_evaluated +4826,37020,17.669516,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.96240234,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,19.0,730.7548666186012,2.5754498304135963e-47,Donor-sugar positioning loop,True,assigned_too_few_test_positives +4827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged aromatic assembly interfaces,False,no_term_above_threshold +4828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic regulatory prion-like IDRs,False,no_term_above_threshold +4829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLiM-rich low-complexity tails,False,no_term_above_threshold +4830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil and low-complexity scaffolds,False,no_term_above_threshold +4831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal CDA/Nudix motif hotspots,False,no_term_above_threshold +4832,36499,19.332071,0.85253906,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.85253906,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,20.0,0.0,1.0,N-terminal GSP-rich glycine peak,True,assigned_too_few_test_positives +4833,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity interfacial interaction segments,False,no_term_above_threshold +4834,43624,16.0,0.8227539,Homedomain-like superfamily,interpro,87384,DNA-binding,0.7211914,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.6866912092815707,0.011950397114767648,0.007089056269384138,,1.6857528930019114,1.0,18.0,4.87817051219113,0.294972066461581,DNA-binding and helical repeats,True,assigned_and_evaluated +4835,38873,15.803325,0.9658203,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.88964844,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9943161634103019,0.36293859649122806,0.002215330084182543,0.6,163.83048245614034,8.0,12.0,114.21647509578544,1.424712212356295e-15,Conserved hydrophobic helical packing,True,assigned_and_evaluated +4836,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SP/TP-rich disordered tails,False,no_term_above_threshold +4837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AlaRS editing-domain activation,False,no_term_above_threshold +4838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Processive membrane glycosyltransferase cores,False,no_term_above_threshold +4839,64148,26.886456,0.7416992,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7416992,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8566036404684634,0.4858644037487361,0.008418254319893664,0.42105263157894735,57.715576803205124,10.0,17.0,52.345039508340655,1.2883416750483856e-15,HTH-adjacent allosteric linker,True,assigned_and_evaluated +4840,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NAD kinase catalytic core,False,no_term_above_threshold +4841,82029,29.836761,0.9086914,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.88916016,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,17.0,165.95193913527555,3.1843570055344877e-32,Transporter cytosolic loop-helix junctions,True,assigned_too_few_test_positives +4842,38873,18.572006,0.76220703,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.640625,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8967140319715808,0.5194906850644556,0.002215330084182543,0.4,234.4980952380953,13.0,14.0,159.08723316912972,3.4776660445681377e-28,ABC NBD active-site loop,True,assigned_and_evaluated +4843,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse mid-protein residue activations,False,no_term_above_threshold +4844,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane glycan/lipid transferases,False,no_term_above_threshold +4845,25169,16.172306,0.72021484,pilus,go_cc,25169,pilus,0.72021484,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.6933836589698046,0.24577364249495398,0.002215330084182543,0.2,110.94222222222224,0.0,15.0,0.0,1.0,Post-cleavage acidic disordered linkers,True,assigned_and_evaluated +4846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasm-proximal signaling TM helix,False,no_term_above_threshold +4847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved PAPS-binding sulfotransferase core,False,no_term_above_threshold +4848,38873,19.175203,0.8613281,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7685547,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9925399644760213,0.5402834008097166,0.002215330084182543,0.6,243.8839271255061,9.0,9.0,171.32471264367817,1.8650004750458193e-20,Sigma-54 EBP AAA+ motif,True,assigned_and_evaluated +4849,63774,16.222616,0.7651367,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.7651367,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,19.0,0.0,1.0,Surface aromatic G/T binding loops,True,assigned_too_few_test_positives +4850,36354,23.839087,0.9970703,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9814453,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,12.0,12.0,214.4640287769784,2.8635201754506504e-28,RRM-disordered linker activation,True,assigned_too_few_test_positives +4851,83267,19.36316,0.8286133,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.8286133,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,15.0,0.0,1.0,Amphipathic terminal interaction patches,True,assigned_too_few_test_positives +4852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich coiled-coil bundles,False,no_term_above_threshold +4853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated alpha-helical rod scaffolds,False,no_term_above_threshold +4854,41979,15.885937,0.7885742,Immunoglobulin-like domain,interpro,63951,Immunoglobulin-like domain superfamily,0.75927734,53,ip,IPR007110,interpro:ip:IPR007110,,,,,,,,14.0,20.0,129.2095975232198,1.7627440173243495e-27,Beta-strand modular domains,True,assigned_too_few_test_positives +4855,36776,16.744345,0.9682617,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.85009766,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.975640456093588,0.06272683932971848,0.002658396101019052,,23.59574606119577,1.0,19.0,16.780467210807767,0.09519666082503377,Basic nucleic acid-binding segments,True,assigned_and_evaluated +4856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate/oxyanion-binding catalytic motifs,False,no_term_above_threshold +4857,64058,26.379444,0.7338867,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.71972656,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8159034456404051,0.274219625989263,0.006202924235711121,0.14285714285714285,44.20812113269762,15.0,15.0,113.99808795411089,4.589611073054062e-31,C-terminal aromatic anchoring/interface helix,True,assigned_and_evaluated +4858,46277,16.986563,0.66064453,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.66064453,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.6288351007852343,0.22324149783166175,0.004873726185201595,0.2727272727272727,45.80509641873278,12.0,19.0,118.78665117051303,5.70938004453961e-23,OB-fold ssDNA-binding modules,True,assigned_and_evaluated +4859,64058,28.036446,0.7060547,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.7060547,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8554869116616777,0.6362677289199536,0.006202924235711121,0.6428571428571429,102.57544744088109,18.0,18.0,113.99808795411089,4.371993551442556e-37,Rossmann oxidoreductase helical lid,True,assigned_and_evaluated +4860,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical interface module,False,no_term_above_threshold +4861,45804,21.413258,0.91748047,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.87597656,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,17.0,0.0,1.0,Transporter transmembrane helices,True,assigned_too_few_test_positives +4862,85364,21.463928,0.9970703,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9970703,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,18.0,284.3874859708193,6.285282157931668e-41,Alpha-beta transition hinges,True,assigned_too_few_test_positives +4863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse nonspecific background activation,False,no_term_above_threshold +4864,63960,38.99217,0.86376953,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.86376953,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,FAD-binding beta-loop interface,True,assigned_too_few_test_positives +4865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Toprim DNA-contact activation,False,no_term_above_threshold +4866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long coiled-coil scaffolds,False,no_term_above_threshold +4867,87384,20.772602,0.6791992,DNA-binding,keyword,87384,DNA-binding,0.6791992,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.604672770335421,0.05280812266333118,0.043863535666814356,,1.2039185136478634,2.0,15.0,1.6333401821793025,0.546091112796285,Coiled-coil/collagen helical repeats,True,assigned_and_evaluated +4868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sandwich ligand-recognition surfaces,False,no_term_above_threshold +4869,36115,18.96406,0.90478516,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8959961,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,14.0,0.0,1.0,Voltage-sensor S4 helix,True,assigned_too_few_test_positives +4870,45324,17.54959,0.9638672,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9638672,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,9.0,14.0,351.63106159895153,8.81977291748798e-22,Pre-PbH1 beta-solenoid motif,True,assigned_and_evaluated +4871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass intramembrane enzymes and transporters,False,no_term_above_threshold +4872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse ABC NBD activation,False,no_term_above_threshold +4873,47529,15.721843,0.7036133,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7036133,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.692938420348059,0.030937057009109842,0.007089056269384138,,4.364058604347557,0.0,19.0,0.0,1.0,OMP beta-barrel strand-junction signal,True,assigned_and_evaluated +4874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface helix hotspot,False,no_term_above_threshold +4875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical oligomerization interfaces,False,no_term_above_threshold +4876,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP transsulfuration N-terminal motif,False,no_term_above_threshold +4877,49121,16.701756,0.9477539,"Signal transduction response regulator, C-terminal effector",interpro,36499,"Zinc finger, GATA-type",0.91748047,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase CA-REC boundary,True,assigned_too_few_test_positives +4878,36115,26.213074,0.9970703,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9970703,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,13.0,18.0,267.45100069013114,7.83369674475632e-30,BTB/TRAF adaptor PPI modules,True,assigned_too_few_test_positives +4879,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal dominant activation,False,no_term_above_threshold +4880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenine methyltransferase DNA-recognition TRDs,False,no_term_above_threshold +4881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature low-complexity membrane-associated regions,False,no_term_above_threshold +4882,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular/periplasmic enzyme/receptor ectodomains,False,no_term_above_threshold +4883,45317,19.250593,0.91552734,"Six-bladed beta-propeller, TolB-like",interpro,45317,"Six-bladed beta-propeller, TolB-like",0.91552734,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,3.0,16.0,143.31971153846155,2.285666401336094e-06,His/acidic beta-rich catalytic cores,True,assigned_too_few_test_positives +4884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic low-complexity linkers,False,no_term_above_threshold +4885,81858,16.56149,0.85498047,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.65185547,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Transmembrane helix detector,True,assigned_too_few_test_positives +4886,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic β-edge junctions,False,no_term_above_threshold +4887,37312,16.875147,1.0,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",1.0,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,19.0,20.0,820.8688405797101,8.582797114260853e-54,Amphipathic packing alpha-helix,True,assigned_too_few_test_positives +4888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure stabilizing residues,False,no_term_above_threshold +4889,81685,22.970469,0.97998047,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9707031,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9974387527839644,0.8808155446086482,0.005316792202038104,0.8333333333333334,165.6667236818099,18.0,18.0,85.66235632183908,6.688146947710768e-35,Pre-kinase boundary linker,True,assigned_and_evaluated +4890,45317,17.157776,0.81103516,"Six-bladed beta-propeller, TolB-like",interpro,45317,"Six-bladed beta-propeller, TolB-like",0.81103516,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,15.0,15.0,764.3717948717948,2.1165549462880107e-43,Extracellular beta-propeller domains,True,assigned_too_few_test_positives +4891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Packed TM helix interfaces,False,no_term_above_threshold +4892,36115,16.896284,0.76220703,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.75146484,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,17.0,0.0,1.0,STAND/NB-ARC P-loop NTPase core,True,assigned_too_few_test_positives +4893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thymidylate synthase superfamily,False,no_term_above_threshold +4894,50338,16.743412,0.7919922,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.7919922,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Pilins/archaellins and GPCR microswitch,True,assigned_too_few_test_positives +4895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane loop activation,False,no_term_above_threshold +4896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible fusion/transport domains,False,no_term_above_threshold +4897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease N-terminal boundary activation,False,no_term_above_threshold +4898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic helical repeat scaffolds,False,no_term_above_threshold +4899,46284,20.690979,0.9526367,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9526367,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,19.0,0.0,1.0,PAS/GAF sensory beta-strands,True,assigned_too_few_test_positives +4900,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arginine-rich segments and residues,False,no_term_above_threshold +4901,46284,15.829724,0.8125,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.8125,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,8.0,16.0,596.21,4.641122346537395e-21,Active-site helix–loop–β segments,True,assigned_too_few_test_positives +4902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal acidic amphipathic loop motif,False,no_term_above_threshold +4903,49061,28.420824,0.9951172,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9951172,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9986861500993399,0.8396402975719991,0.012405848471422242,1.0,67.68100541500007,18.0,18.0,98.87396351575455,5.3190513750556736e-36,WD40 loop-to-strand junctions,True,assigned_and_evaluated +4904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arg-rich synthetase domain motif,False,no_term_above_threshold +4905,47128,15.966529,0.7915039,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.7915039,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,0.0,17.0,0.0,1.0,Tailspike-like beta-solenoid adhesins,True,assigned_too_few_test_positives +4906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16 peptidase HxxEH motif,False,no_term_above_threshold +4907,88161,42.499157,0.6386719,Transmembrane helix,keyword,88161,Transmembrane helix,0.6386719,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.660253101866333,0.4234468506232939,0.1847585290208241,0.3764988009592326,2.2918933857476604,19.0,19.0,5.4274920345926265,2.5090631899926267e-14,Single/paired transmembrane helix anchors,True,assigned_and_evaluated +4908,85682,30.80915,0.7470703,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7470703,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.6925358422939069,0.3734256512694968,0.011076650420912717,0.36,33.71286779661017,17.0,17.0,102.26586620926243,2.6394552661124587e-34,NAD(P) adenosine-binding subdomain,True,assigned_and_evaluated +4909,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short low-basic amphipathic helices,False,no_term_above_threshold +4910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site gating loops,False,no_term_above_threshold +4911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic charged helix-capping scaffold,False,no_term_above_threshold +4912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FG/YG/PG low-complexity IDRs,False,no_term_above_threshold +4913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered segments,False,no_term_above_threshold +4914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA-contact catalytic residues,False,no_term_above_threshold +4915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-to-helix TM entry motifs,False,no_term_above_threshold +4916,87317,18.17984,0.76708984,Cleavage on pair of basic residues,keyword,88058,Signal,0.65234375,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.7493585452922803,0.04290789146782954,0.007089056269384138,,6.052694440180705,6.0,17.0,29.805532411264792,5.945689545085939e-08,Secretory luminal ectodomains,True,assigned_and_evaluated +4917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytokine N-termini and interface hotspots,False,no_term_above_threshold +4918,81858,17.437435,0.93310547,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6459961,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Hydrophobic transmembrane helices,True,assigned_too_few_test_positives +4919,82608,15.731421,0.87597656,Ankyrin repeat-containing domain,gene3d,82608,Ankyrin repeat-containing domain,0.87597656,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.9110993775011116,0.06345664623157363,0.003544528134692069,,17.90270631808271,0.0,16.0,0.0,1.0,Alpha-helical gene-regulatory domains,True,assigned_and_evaluated +4920,37020,16.854538,0.91308594,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.77978516,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,15.0,20.0,612.5445205479451,5.848463071548215e-40,Membrane-interface glycosyltransferase segments,True,assigned_too_few_test_positives +4921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass membrane transporter helices,False,no_term_above_threshold +4922,83419,18.69044,0.90234375,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.85546875,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,15.0,18.0,302.9522357723577,8.93547183013231e-36,Extracellular glycan-binding beta-domains,True,assigned_too_few_test_positives +4923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved alpha/beta catalytic core,False,no_term_above_threshold +4924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ArgJ TGxGG turn motif,False,no_term_above_threshold +4925,88161,73.05686,0.83496094,Transmembrane helix,keyword,88159,Transmembrane,0.8300781,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8846007976227714,0.6751306903031379,0.1847585290208241,0.8585131894484412,3.654124623535209,7.0,19.0,1.9996023285341253,0.07592241947679561,Hydrophobic membrane-targeting alpha-helices,True,assigned_and_evaluated +4926,85672,28.215946,0.87841797,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.87841797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9115701135624592,0.17759498478016852,0.01595037660611431,0.05555555555555555,11.134218906912233,1.0,19.0,2.1060049452490284,0.5953561119820383,Helix-to-strand capping loops,True,assigned_and_evaluated +4927,64058,16.927485,0.64501953,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.64453125,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6044519457359403,0.17749277380424922,0.006202924235711121,0.21428571428571427,28.61437074829932,15.0,15.0,113.99808795411089,4.589611073054062e-31,Dehydrogenase C-terminal capping segment,True,assigned_and_evaluated +4928,64155,20.916607,0.74902344,Ribonuclease H superfamily,interpro,64155,Ribonuclease H superfamily,0.74902344,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,14.0,14.0,277.30697674418604,2.0115371378814856e-34,N-terminal nucleic-acid extensions,True,assigned_too_few_test_positives +4929,63960,29.825739,0.9995117,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9995117,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,19.0,19.0,193.57467532467533,3.1320939821269373e-43,Flavoprotein core hydrophobic beta-strands,True,assigned_too_few_test_positives +4930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered coil-to-helix DNA contacts,False,no_term_above_threshold +4931,85672,51.589237,0.9458008,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9350586,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8822727500125068,0.5266635337021736,0.01595037660611431,0.7222222222222222,33.01887765460572,17.0,20.0,34.01197986577181,1.6696913395218867e-24,P-loop ATPase hinge motif,True,assigned_and_evaluated +4932,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical and membrane segments,False,no_term_above_threshold +4933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scattered helical/disordered residue peaks,False,no_term_above_threshold +4934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended partner-engagement interfaces,False,no_term_above_threshold +4935,37894,17.640368,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8417969,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,10.0,638.7964285714286,4.250327627086626e-25,SDR lid N-cap motif,True,assigned_too_few_test_positives +4936,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein insertion/biogenesis,False,no_term_above_threshold +4937,37468,18.032274,0.8046875,"Zinc finger, RING-type",interpro,88261,Zinc,0.6040039,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,11.0,0.0,1.0,Zinc-finger modules with disordered flanks,True,assigned_too_few_test_positives +4938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfate/phosphate nucleophile loop,False,no_term_above_threshold +4939,38317,21.581303,0.8701172,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8701172,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6748253968253969,0.013997941615604227,0.0031014621178555605,,4.51333631805982,0.0,20.0,0.0,1.0,Alphaproteobacterial enzyme loop signal,True,assigned_and_evaluated +4940,87697,18.738588,0.87109375,Knottin,keyword,87413,Disulfide bond,0.6669922,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9288744768907077,0.10197483454076399,0.017279574656623838,,5.901466706628316,0.0,19.0,0.0,1.0,Aromatic-centered beta-strand edge motif,True,assigned_and_evaluated +4941,52941,18.719551,0.8696289,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.83935547,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,16.0,17.0,245.0387875674287,1.4394641651334948e-37,TM helix-loop junctions,True,assigned_too_few_test_positives +4942,81858,17.004463,0.95214844,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6928711,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helices and flanks,True,assigned_too_few_test_positives +4943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix hinges and reentrant loops,False,no_term_above_threshold +4944,83302,17.107037,0.95654297,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9501953,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.972233465554926,0.16345226023622014,0.004873726185201595,,33.53743194119535,3.0,13.0,47.44376657824934,5.798611922395195e-05,PotA C-terminal YKG motif,True,assigned_and_evaluated +4945,64016,16.206758,0.83935547,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.83935547,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.875968253968254,0.04804215266562206,0.0031014621178555605,,15.490162652329856,0.0,16.0,0.0,1.0,Nucleotidyltransferase phosphate-binding loop,True,assigned_and_evaluated +4946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-centered interface segments,False,no_term_above_threshold +4947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDR linkers,False,no_term_above_threshold +4948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core catalytic alpha/beta tracts,False,no_term_above_threshold +4949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered low-complexity patches,False,no_term_above_threshold +4950,43624,17.769045,0.85839844,Homedomain-like superfamily,interpro,87384,DNA-binding,0.6879883,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8832691878625614,0.042124304674503184,0.007089056269384138,,5.9421597281471055,1.0,16.0,5.487941826215022,0.26562699357825786,Cationic alpha-helical patches,True,assigned_and_evaluated +4951,37894,20.826101,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99072266,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,Hydrophobic helix C-cap motif,True,assigned_too_few_test_positives +4952,49061,19.559963,0.74316406,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.74316406,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.6129510350573607,0.052773435415197606,0.012405848471422242,,4.253915847575035,0.0,14.0,0.0,1.0,Beta-propeller blade strand motif,True,assigned_and_evaluated +4953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal IDRs and TM helices,False,no_term_above_threshold +4954,52941,25.637714,0.99853516,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9946289,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,17.0,260.353711790393,4.679078553617228e-41,Helix-breaking TM coil linkers,True,assigned_too_few_test_positives +4955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional core TM helix,False,no_term_above_threshold +4956,25167,17.80927,0.77001953,cell outer membrane,go_cc,25167,cell outer membrane,0.77001953,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.8946919079435784,0.1958479267666782,0.005316792202038104,,36.83573089269939,2.0,18.0,15.159166031019577,0.01297408691387849,Alternating hydrophobic beta-strand face,True,assigned_and_evaluated +4957,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DMSO reductase bis-MGD loop,False,no_term_above_threshold +4958,64003,20.8763,0.99609375,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.85595703,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,15.0,15.0,130.4617067833698,6.27862990657517e-32,C2H2 beta-strand X-F/Y motif,True,assigned_and_evaluated +4959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic alpha-helical interfaces,False,no_term_above_threshold +4960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated disordered scaffold regions,False,no_term_above_threshold +4961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged catalytic lids/coiled-coils,False,no_term_above_threshold +4962,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytochrome c disordered C-termini,False,no_term_above_threshold +4963,82029,24.692198,0.99902344,MFS general substrate transporter like domains,gene3d,88162,Transport,0.6176758,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Transmembrane helix hinge/anchor residues,True,assigned_too_few_test_positives +4964,88022,15.633247,0.72216797,Ribosomal protein,keyword,88022,Ribosomal protein,0.72216797,279,keywords,Ribosomal protein,keyword:keywords:Ribosomal protein,50.0,2257.0,0.6160262800181243,0.0624487002078022,0.022153300841825433,0.06,2.8189343273801915,4.0,14.0,25.731981009926628,2.5678860195463806e-05,Generic beta-strand edge/turn signal,True,assigned_and_evaluated +4965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory all-alpha helical cores,False,no_term_above_threshold +4966,85656,21.692883,0.71435547,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.71435547,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9258412698412699,0.6888071213163756,0.0031014621178555605,0.7142857142857143,222.09109611586567,16.0,16.0,141.281990521327,1.474482880092783e-34,Alpha/beta-hydrolase lid activation,True,assigned_and_evaluated +4967,47717,16.321642,0.9892578,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.81591797,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,15.0,16.0,256.3976490825688,1.46477025389507e-35,Post-DEAD/DEAH coupling helix,True,assigned_too_few_test_positives +4968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-binding Cys/His clusters,False,no_term_above_threshold +4969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent beta-barrel juxtamembrane motif,False,no_term_above_threshold +4970,50806,18.656534,0.99121094,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.8979492,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,Helix N-cap turns,True,assigned_too_few_test_positives +4971,36668,18.466753,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9736328,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,14.0,14.0,532.3303571428571,2.0509194733270867e-38,Adenylation-domain C-terminal lid,True,assigned_too_few_test_positives +4972,87697,17.668844,0.8388672,Knottin,keyword,87413,Disulfide bond,0.7241211,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8884187648840489,0.06802520409379018,0.017279574656623838,,3.936740657427806,0.0,20.0,0.0,1.0,Tandem repeat register detector,True,assigned_and_evaluated +4973,87873,16.732414,0.6489258,Oxidoreductase,keyword,87873,Oxidoreductase,0.6489258,537,keywords,Oxidoreductase,keyword:keywords:Oxidoreductase,48.0,2257.0,0.6854345857854233,0.14346837678289728,0.021267168808152416,,6.746002633312482,5.0,12.0,10.477470828061298,0.00011368870129852077,Structural packing alpha-helix,True,assigned_and_evaluated +4974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asx-rich β-solenoid repeats,False,no_term_above_threshold +4975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-transmembrane helical/repeat interaction scaffolds,False,no_term_above_threshold +4976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich beta-edge/linker hinge,False,no_term_above_threshold +4977,46277,20.493397,0.9638672,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9638672,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9826357969723953,0.19387763344300912,0.004873726185201595,0.18181818181818182,39.78016533462469,4.0,14.0,53.73681838666065,1.4503070594298694e-06,Strand-edge turn motifs,True,assigned_and_evaluated +4978,55053,18.382614,0.8334961,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.8334961,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,10.0,18.0,306.6923868312757,3.055020058021873e-23,Aromatic-glycine pocket-lining segments,True,assigned_too_few_test_positives +4979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-hairpin α/β interaction surfaces,False,no_term_above_threshold +4980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand active-site scaffold,False,no_term_above_threshold +4981,85712,15.843926,0.9506836,3.40.630.30,gene3d,85712,3.40.630.30,0.9506836,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,19.0,0.0,1.0,Short hydrophobic non-catalytic boundary segments,True,assigned_too_few_test_positives +4982,36091,18.53554,0.9589844,GNAT domain,interpro,85712,3.40.630.30,0.92285156,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,13.0,0.0,1.0,Pocket-lining sensory beta strands,True,assigned_too_few_test_positives +4983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil transition detector,False,no_term_above_threshold +4984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Dimer interface allosteric helices,False,no_term_above_threshold +4985,49116,22.812132,0.9199219,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9199219,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9985790408525755,0.6402564102564103,0.002215330084182543,0.6,289.0117435897437,16.0,20.0,69.63036496350365,1.2077902373367953e-27,Alpha-solenoid and transmembrane helix marker,True,assigned_and_evaluated +4986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich low-complexity IDRs,False,no_term_above_threshold +4987,63831,16.075905,0.7158203,F-box-like domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.68896484,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7316377906115801,0.007040854343510839,0.002658396101019052,,2.648534708883994,0.0,14.0,0.0,1.0,"Traffic NTPase, IF-2 loop motif",True,assigned_and_evaluated +4988,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal effector-domain activation,False,no_term_above_threshold +4989,85664,16.132439,0.9111328,Glycogen Phosphorylase B;,gene3d,85656,alpha/beta hydrolase,0.8149414,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,20.0,20.0,331.22777777777776,1.2127040143295405e-49,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +4990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended charged interaction scaffolds,False,no_term_above_threshold +4991,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization helices,False,no_term_above_threshold +4992,88058,34.84514,0.69628906,Signal,keyword,88058,Signal,0.69628906,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7732683086157356,0.2337800208733607,0.09127159946832078,,2.5613665393746365,0.0,19.0,0.0,1.0,Small-residue disordered N-terminus,True,assigned_and_evaluated +4993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell wall-binding repeats,False,no_term_above_threshold +4994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane metalloprotein helix bundle,False,no_term_above_threshold +4995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap transition motif,False,no_term_above_threshold +4996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early mature region activation,False,no_term_above_threshold +4997,82107,16.376705,0.6645508,1.20.1280.50,gene3d,82107,1.20.1280.50,0.6645508,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,17.0,0.0,1.0,Aromatic-anchored acidic beta-repeats,True,assigned_too_few_test_positives +4998,87326,22.492083,0.6645508,Coiled coil,keyword,87326,Coiled coil,0.6645508,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7168648161200714,0.11938545768108835,0.03943287549844927,,3.027561550406926,12.0,16.0,9.45564601395644,1.73356132038528e-10,Soluble coiled-coils and bundles,True,assigned_and_evaluated +4999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PX domain detector,False,no_term_above_threshold +5000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Pro-rich disordered regions,False,no_term_above_threshold +5001,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase RecA2 C-terminal lobe,False,no_term_above_threshold +5002,64148,19.80551,0.6586914,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6586914,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6998259724377969,0.12073323662137106,0.008418254319893664,0.05263157894736842,14.341837634443921,15.0,18.0,74.15547263681593,1.2484342145560243e-26,HTH regulator effector-binding domain,True,assigned_and_evaluated +5003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"RTX-like acidic repeats, glycine loops",False,no_term_above_threshold +5004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glucan binding CBM modules,False,no_term_above_threshold +5005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core packing near cofactors,False,no_term_above_threshold +5006,36354,19.606707,0.9091797,RNA recognition motif domain,interpro,87697,Knottin,0.72021484,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,8.0,0.0,1.0,ABC NBD A-loop start,True,assigned_too_few_test_positives +5007,87276,47.413006,0.72558594,Cell membrane,keyword,88161,Transmembrane helix,0.7060547,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7083272096062411,0.34818939397733034,0.11120957022596367,0.46215139442231074,3.130930128314082,17.0,18.0,7.749617701929841,1.050934808049714e-14,N-terminal signal-anchor helix,True,assigned_and_evaluated +5008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane acidic-aromatic motifs,False,no_term_above_threshold +5009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity regions,False,no_term_above_threshold +5010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered SLiM/PTM linkers/tails,False,no_term_above_threshold +5011,87697,23.673874,0.92529297,Knottin,keyword,87697,Knottin,0.92529297,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8598240503109754,0.054830058314607535,0.017279574656623838,,3.173113887591518,0.0,19.0,0.0,1.0,RTX hydrophobic-basic motif,True,assigned_and_evaluated +5012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Targeting peptides and protease motifs,False,no_term_above_threshold +5013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic C-terminal tails,False,no_term_above_threshold +5014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer pore helix–loop boundary,False,no_term_above_threshold +5015,87326,29.442028,0.6533203,Coiled coil,keyword,87326,Coiled coil,0.6533203,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.65364961233882,0.1639189918739506,0.03943287549844927,0.12359550561797752,4.156911962466365,7.0,17.0,5.1913350664858875,0.0003387372001237289,Charged amphipathic coiled-coil helices,True,assigned_and_evaluated +5016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low complexity segments,False,no_term_above_threshold +5017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HIT/CWF19/Leloir nucleotide pockets,False,no_term_above_threshold +5018,36535,20.692314,0.9663086,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8833008,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9470627503337783,0.8904430660168365,0.004430660168365086,0.9,200.973,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Conserved kinase N-lobe motif,True,assigned_and_evaluated +5019,45714,20.675455,0.9946289,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.9814453,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,12.0,0.0,1.0,Histidine kinase DHp H-box,True,assigned_too_few_test_positives +5020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic ligand-sensing helical bundles,False,no_term_above_threshold +5021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic intrinsically disordered regions,False,no_term_above_threshold +5022,46932,20.925682,0.9589844,Zinc finger C2H2-type,interpro,29166,zinc ion binding,0.8745117,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9957276368491321,0.7610164467393382,0.004430660168365086,0.8,171.76141202906865,14.0,16.0,94.67944646098003,1.0680369657643077e-26,Disordered zinc-finger linkers,True,assigned_and_evaluated +5023,52940,17.754055,0.9995117,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.9868164,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,17.0,17.0,608.3775510204082,3.7212930519664824e-47,ANL pre-ATP-binding A3/A4 loop,True,assigned_too_few_test_positives +5024,31094,16.485188,0.9785156,phosphopantetheine binding,go_mf,69093,"ANL, N-terminal domain",0.8510742,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9474410324877615,0.4250337092916903,0.004430660168365086,0.8,95.93010818713451,0.0,14.0,0.0,1.0,Active-site gating segments,True,assigned_and_evaluated +5025,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp KxxAL lysine motif,False,no_term_above_threshold +5026,36409,24.766775,0.98779297,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.98779297,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,13.0,0.0,1.0,Cys-cluster metal-binding motifs,True,assigned_too_few_test_positives +5027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface anchor residue hotspots,False,no_term_above_threshold +5028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-biased core hydrophobes,False,no_term_above_threshold +5029,87523,17.033783,0.6098633,Glycosidase,keyword,87523,Glycosidase,0.6098633,108,keywords,Glycosidase,keyword:keywords:Glycosidase,8.0,2257.0,0.6169964428634949,0.15038566882829177,0.003544528134692069,0.125,42.42755681818181,15.0,19.0,88.8098311817279,1.7534632821988497e-27,CAZyme accessory region activation,True,assigned_and_evaluated +5030,59224,28.00807,0.97314453,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97314453,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,16.0,16.0,137.37557603686636,2.308526036036146e-34,N-terminal ABH beta-strand cue,True,assigned_and_evaluated +5031,47529,17.272886,0.8388672,Immunoglobulin-like fold,interpro,87697,Knottin,0.78027344,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9037399598393574,0.050724232997131316,0.007089056269384138,,7.155287117157837,0.0,15.0,0.0,1.0,Secondary-structure edge interface hotspots,True,assigned_and_evaluated +5032,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible charged helix-loop arm,False,no_term_above_threshold +5033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic lid/specificity loop,False,no_term_above_threshold +5034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved Asparaginase LR[ND]DY motif,False,no_term_above_threshold +5035,87882,29.52838,0.8833008,Palmitate,keyword,88058,Signal,0.7558594,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9980008884940027,0.5035353535353535,0.002658396101019052,0.6666666666666666,189.41321548821546,13.0,20.0,43.300167597765366,3.22667624829307e-19,Lipoprotein signal peptide cleavage,True,assigned_and_evaluated +5036,85675,16.510263,0.94628906,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9238281,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,18.0,19.0,518.1931434089811,9.602462486774284e-48,VWA MIDAS-face adhesion surface,True,assigned_too_few_test_positives +5037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interaction modules,False,no_term_above_threshold +5038,64016,16.838924,0.7602539,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.75683594,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7735238095238095,0.1216773373062118,0.0031014621178555605,,39.23225004287429,0.0,16.0,0.0,1.0,Metal/redox motif flanks,True,assigned_and_evaluated +5039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical chromatin-recognition modules,False,no_term_above_threshold +5040,85762,23.283873,0.75683594,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.7446289,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,18.0,205.58965517241379,1.4365296813653038e-41,Redox cofactor access lids,True,assigned_too_few_test_positives +5041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity interaction tracts,False,no_term_above_threshold +5042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-anchored regulator TM-boundary peak,False,no_term_above_threshold +5043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal appended segment,False,no_term_above_threshold +5044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal coiled-coil scaffolds,False,no_term_above_threshold +5045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal IDR and signal-peptide activation,False,no_term_above_threshold +5046,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenylyl/guanylyl cyclase active site,False,no_term_above_threshold +5047,46079,17.34439,0.8408203,Tetratricopeptide-like helical domain superfamily,interpro,88009,Repeat,0.6855469,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.8504730563554093,0.024106585842146224,0.0057598582188746125,,4.185274172748002,0.0,19.0,0.0,1.0,Secondary-structure boundary signal,True,assigned_and_evaluated +5048,38873,15.640468,0.8754883,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.83740234,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7893428063943163,0.18876491991246086,0.002215330084182543,,85.20848484848484,3.0,15.0,34.26494252873564,0.00015551355235484857,Helicase pre-P-loop Q-motif helix,True,assigned_and_evaluated +5049,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+ active-site proximal loops,False,no_term_above_threshold +5050,85364,19.666094,0.98291016,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.98291016,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,10.0,16.0,188.197601010101,2.747407174679299e-21,Gly/Pro-rich beta–alpha hinge loops,True,assigned_too_few_test_positives +5051,36272,16.635643,0.9790039,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9790039,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,16.0,0.0,1.0,HhH-GPD-like acidic hairpin,True,assigned_too_few_test_positives +5052,59229,28.869976,0.9736328,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9736328,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9513059047915612,0.7891700792021145,0.0101905183872397,0.8260869565217391,77.44160298952923,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Rossmann beta-strand hydrophobic anchors,True,assigned_and_evaluated +5053,45288,16.083519,0.9296875,CheY-like superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7402344,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,0.0,10.0,0.0,1.0,ABC NBD interface helix,True,assigned_too_few_test_positives +5054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-active amphipathic helices,False,no_term_above_threshold +5055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme C-terminal activation,False,no_term_above_threshold +5056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral RdRp region marker,False,no_term_above_threshold +5057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic sensory beta-strand motif,False,no_term_above_threshold +5058,37341,28.091185,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9785156,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 blade strand-loop junction,True,assigned_and_evaluated +5059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Focal activation on structured segments,False,no_term_above_threshold +5060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature globular domain activation,False,no_term_above_threshold +5061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transporter TM helices,False,no_term_above_threshold +5062,83419,16.847416,0.9213867,2.60.120.200,gene3d,87714,Lectin,0.6894531,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,16.0,16.0,363.5426829268293,5.002428248529944e-41,Extracellular lectin/SUN domains and linkers,True,assigned_too_few_test_positives +5063,59229,35.038334,0.9770508,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9770508,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8858841617687128,0.7496713892886226,0.0101905183872397,0.7391304347826086,73.56557937497483,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Motif I SAM-binding loop,True,assigned_and_evaluated +5064,61392,20.08119,0.99121094,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.99121094,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9869841269841271,0.19508281573498965,0.0031014621178555605,,62.90027358769595,0.0,14.0,0.0,1.0,Glycine-centered beta-strand N-caps,True,assigned_and_evaluated +5065,30398,21.768972,0.6459961,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.6459961,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.58690196713349,0.1858057759697104,0.004873726185201595,0.18181818181818182,38.12396694214876,9.0,9.0,72.00603864734299,4.4854289538285064e-17,ABC C-loop helix-loop,True,assigned_and_evaluated +5066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic surface assembly interfaces,False,no_term_above_threshold +5067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alpha-helical clusters,False,no_term_above_threshold +5068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic accessory helical regions,False,no_term_above_threshold +5069,63831,17.596046,0.9296875,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9296875,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9187398193395528,0.017846338408628797,0.002658396101019052,,6.713197631379199,0.0,20.0,0.0,1.0,Short conserved helical segments,True,assigned_and_evaluated +5070,87882,40.420246,0.8935547,Palmitate,keyword,88058,Signal,0.6308594,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.998963423663557,0.5771825396825397,0.002658396101019052,1.0,217.11683201058202,19.0,20.0,63.284860335195525,1.7158666977028273e-33,Sec signal peptide cleavage motif,True,assigned_and_evaluated +5071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC-F NBD helix motif,False,no_term_above_threshold +5072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OHCU decarboxylase active site,False,no_term_above_threshold +5073,36914,18.341894,0.7529297,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.7529297,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,18.0,0.0,1.0,Disordered proline-rich and loop hotspots,True,assigned_too_few_test_positives +5074,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered tethering regions,False,no_term_above_threshold +5075,81799,15.643668,0.9794922,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6821289,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,11.0,15.0,424.48608414239476,1.0747467023988119e-27,Sensor-2 phosphate-sensing helix,True,assigned_too_few_test_positives +5076,88009,21.591852,0.6303711,Repeat,keyword,88009,Repeat,0.6303711,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.588593802803771,0.09216090641131522,0.07266282676118742,,1.268336376648405,4.0,15.0,2.3641536555142504,0.1302102809401863,N-terminal disordered pre-sequences,True,assigned_and_evaluated +5077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain entry motif,False,no_term_above_threshold +5078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic regulatory helices and tails,False,no_term_above_threshold +5079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal juxtamembrane topogenic module,False,no_term_above_threshold +5080,63960,33.84433,0.7998047,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.7998047,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,Rossmann FAD redox interface,True,assigned_too_few_test_positives +5081,-1,,,,,-1,,,0,,,,,,,,,,,,,,,JmjN-like pre-catalytic helical lobe,False,no_term_above_threshold +5082,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory disordered tails,False,no_term_above_threshold +5083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase ATP-binding lobe,False,no_term_above_threshold +5084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic coiled-coil efflux stalks,False,no_term_above_threshold +5085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IPT/TIG Ig-like loop activation,False,no_term_above_threshold +5086,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural contact hotspots,False,no_term_above_threshold +5087,45290,17.543835,0.90234375,Protein kinase-like domain superfamily,interpro,88153,Transferase,0.7109375,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9255621829151242,0.04535364138495643,0.0057598582188746125,,7.874089892757435,0.0,16.0,0.0,1.0,Metal-assisted anionic catalysis,True,assigned_and_evaluated +5088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal coiled-coil tails,False,no_term_above_threshold +5089,36499,20.21623,0.8857422,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.8857422,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,20.0,0.0,1.0,Broad N-terminal activation regions,True,assigned_too_few_test_positives +5090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16-like fold scaffold helices,False,no_term_above_threshold +5091,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transmembrane hairpins,False,no_term_above_threshold +5092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic nucleic acid-binding interfaces,False,no_term_above_threshold +5093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity activation,False,no_term_above_threshold +5094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical secretion signals,False,no_term_above_threshold +5095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MnmG/MTO1 C-terminal tRNA-binding motif,False,no_term_above_threshold +5096,37312,16.46936,1.0,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",1.0,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,18.0,19.0,818.5949656750571,4.3313349653425253e-51,C-terminal noncatalytic helix–coil regions,True,assigned_too_few_test_positives +5097,37894,19.313484,0.9794922,Short-chain dehydrogenase/reductase SDR,interpro,49230,Acyl-CoA N-acyltransferase,0.9189453,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,7.0,709.7738095238095,2.2341786607428882e-20,SDR pre-YXXXK catalytic loop,True,assigned_too_few_test_positives +5098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolytic enzyme active-site cores,False,no_term_above_threshold +5099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand hairpin turns,False,no_term_above_threshold +5100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amylase-like C-terminal region,False,no_term_above_threshold +5101,35372,15.930819,0.9140625,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9140625,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,11.0,16.0,482.22867647058825,3.744559734606538e-28,Membrane transporter TM anchor motif,True,assigned_too_few_test_positives +5102,49236,16.726952,0.953125,C-type lectin fold,interpro,49236,C-type lectin fold,0.953125,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9965364120781528,0.26121212121212123,0.002215330084182543,,117.91115151515153,0.0,16.0,0.0,1.0,Hydrophobic Pro-Gly beta-helix motif,True,assigned_and_evaluated +5103,29034,17.465567,0.74316406,GTP binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.73583984,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.6908582923558336,0.37497491186015774,0.008861320336730172,0.4,42.3159188034188,11.0,19.0,75.03787185354692,9.188393017606143e-19,TRAFAC-class GTPase G-domain,True,assigned_and_evaluated +5104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OGDH E1 N-terminal helix,False,no_term_above_threshold +5105,36951,16.598852,0.859375,SET domain,interpro,36951,SET domain,0.859375,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,13.0,0.0,1.0,Prokaryotic translation machinery signature,True,assigned_too_few_test_positives +5106,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic C-terminal beta-strand motif,False,no_term_above_threshold +5107,36010,18.731474,0.9848633,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97314453,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,1.0,18.0,28.310066476733144,0.0576325493068433,Serine hydrolase nucleophile-loop motif,True,assigned_too_few_test_positives +5108,36091,26.157686,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9995117,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,14.0,14.0,377.3481012658228,2.6485674118201105e-36,GNAT acetyltransferase catalytic core,True,assigned_too_few_test_positives +5109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural helix packing residues,False,no_term_above_threshold +5110,45288,16.854103,0.9980469,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9980469,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,19.0,19.0,462.17829457364337,6.130283085627497e-50,Two-component His-Asp phosphotransfer motifs,True,assigned_too_few_test_positives +5111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved sulfatase active site residues,False,no_term_above_threshold +5112,47531,18.938644,0.8066406,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.8066406,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,12.0,18.0,168.42090395480227,6.114074768517847e-25,TIM-barrel C-terminal active-site block,True,assigned_too_few_test_positives +5113,45290,24.716284,0.78222656,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.78222656,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6861031125737007,0.32871935330951724,0.0057598582188746125,0.3076923076923077,57.07073695535234,17.0,18.0,69.34571702244116,1.1231297419159899e-30,C-lobe activation-segment helix,True,assigned_and_evaluated +5114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal targeting arm,False,no_term_above_threshold +5115,87276,28.408432,0.6142578,Cell membrane,keyword,87276,Cell membrane,0.6142578,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.716875270602535,0.4258351103337419,0.11120957022596367,0.46613545816733065,3.829122884554802,16.0,17.0,7.722802415763994,8.007539238073717e-14,Transmembrane helix packing motifs,True,assigned_and_evaluated +5116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered proline-rich interaction hubs,False,no_term_above_threshold +5117,38873,22.298548,0.9550781,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9160156,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9932948490230906,0.2842706988751613,0.002215330084182543,0.4,128.31979347224782,10.0,17.0,100.7792427315754,1.8878855884011034e-18,Walker A P-loop motif,True,assigned_and_evaluated +5118,36409,16.366243,0.9140625,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.9140625,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,9.0,19.0,210.75765907305575,2.573006639837728e-19,Polar low-complexity RBP IDRs,True,assigned_too_few_test_positives +5119,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp fold catalytic core,False,no_term_above_threshold +5120,45324,17.519003,0.94433594,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.94433594,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.4897868561278863,0.002215330084182543,0.002215330084182543,,1.0,14.0,15.0,510.5162079510703,1.865407917563931e-37,PbH1 internal hotspot motif,True,assigned_and_evaluated +5121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic N-terminal helix,False,no_term_above_threshold +5122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His-rich phosphate-binding loops,False,no_term_above_threshold +5123,85364,18.672604,0.9863281,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9863281,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,15.0,19.0,237.7232854864434,7.035555830604122e-34,Short amphipathic coupling helices,True,assigned_too_few_test_positives +5124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His–Asp catalytic microenvironments,False,no_term_above_threshold +5125,86130,22.558245,0.96484375,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9604492,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9993650793650792,0.857535321821036,0.0031014621178555605,1.0,276.49388876429686,17.0,17.0,240.4072580645161,1.7442716280492044e-40,Fungal TF hydrophobic activation segments,True,assigned_and_evaluated +5126,85672,28.503672,0.6586914,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.65722656,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6765408474661063,0.27992168372783716,0.01595037660611431,0.3333333333333333,17.549534449270237,9.0,16.0,22.507927852348995,7.715763388801497e-11,Post Walker A helix motif,True,assigned_and_evaluated +5127,46284,17.072968,0.97753906,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.97753906,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,18.0,0.0,1.0,Nucleic acid beta-strand hotspots,True,assigned_too_few_test_positives +5128,46581,18.256365,0.9995117,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9995117,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,18.0,20.0,155.98517441860466,4.1061566656952337e-38,N-terminal RNP contact motif,True,assigned_too_few_test_positives +5129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class I MTase active-site arginine,False,no_term_above_threshold +5130,38317,18.022512,0.9921875,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98339844,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9972698412698413,0.4100340136054422,0.0031014621178555605,0.14285714285714285,132.20668124392617,0.0,20.0,0.0,1.0,Eukaryotic solenoid repeat scaffolds,True,assigned_and_evaluated +5131,87852,16.02914,0.90478516,Nucleosome core,keyword,87857,Nucleus,0.6557617,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,19.0,0.0,1.0,Nuclear mixed-charge low-complexity IDRs,True,assigned_too_few_test_positives +5132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF C-terminal coupling helix,False,no_term_above_threshold +5133,36449,20.680542,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,13.0,18.0,768.921626984127,4.6836628481461014e-36,C-terminal TM with positive-inside tail,True,assigned_too_few_test_positives +5134,36115,22.181437,0.79541016,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7807617,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,16.0,0.0,1.0,HATPase_c catalytic strand hotspot,True,assigned_too_few_test_positives +5135,61392,22.374935,0.8022461,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.8022461,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.7040634920634921,0.05799813279321475,0.0031014621178555605,,18.700255102040813,13.0,13.0,167.4747191011236,3.5629175766616453e-29,Helical assembly interface segments,True,assigned_and_evaluated +5136,37020,16.923174,0.87158203,"Glycosyl transferase, family 1",interpro,37020,"Glycosyl transferase, family 1",0.87158203,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,18.0,0.0,1.0,Mobile active-site lid loops,True,assigned_too_few_test_positives +5137,45551,17.637486,0.99853516,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.99853516,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,16.0,17.0,320.650756302521,2.0056066827033947e-39,"BTB adaptors, C-terminal IDRs",True,assigned_too_few_test_positives +5138,28025,21.847857,0.9165039,GTPase activity,go_mf,29034,GTP binding,0.75,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9150377609951134,0.6407208437946142,0.002658396101019052,0.8333333333333334,241.01782407407404,9.0,15.0,162.60272727272726,1.3216345903815495e-18,G5-specific P-loop GTPase core,True,assigned_and_evaluated +5139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear N-terminal IDR hubs,False,no_term_above_threshold +5140,64620,18.34929,0.9272461,Histidine kinase/HSP90-like ATPase superfamily,interpro,36499,"Zinc finger, GATA-type",0.8691406,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,19.0,19.0,324.0271739130435,2.7035397615707734e-47,Bergerat-fold GHKL ATPase domain,True,assigned_too_few_test_positives +5141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil hydrophobic core positions,False,no_term_above_threshold +5142,37071,18.2393,0.9609375,Homeodomain,interpro,88150,Transcription regulation,0.6743164,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,20.0,0.0,1.0,Basic region DNA-binding helix,True,assigned_too_few_test_positives +5143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal flavin/PQQ-binding region,False,no_term_above_threshold +5144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SP/TP proline-rich IDRs,False,no_term_above_threshold +5145,52236,24.094461,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99121094,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR helix A start register,True,assigned_too_few_test_positives +5146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter transmembrane helices,False,no_term_above_threshold +5147,46078,17.3601,0.8222656,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.8022461,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,0.0,19.0,0.0,1.0,Helical and beta-solenoid cores,True,assigned_too_few_test_positives +5148,69819,19.657455,0.8823242,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.84765625,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,Conserved ROK/actin-like ATPase C-terminal subdomain,True,assigned_too_few_test_positives +5149,36010,20.072561,0.93603516,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.91796875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,20.0,0.0,1.0,alpha/beta-hydrolase catalytic domain,True,assigned_too_few_test_positives +5150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine recombinase core-binding domain,False,no_term_above_threshold +5151,88160,18.76699,0.76904297,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6508789,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,17.0,18.0,273.3433117583603,1.238197210134836e-40,Outer membrane β-barrel proteins,True,assigned_too_few_test_positives +5152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type I sulfatase catalytic domain,False,no_term_above_threshold +5153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DDT domain and C-terminal linker,False,no_term_above_threshold +5154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD/CDP-AP linker helices,False,no_term_above_threshold +5155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AARAAxxAS helical signature,False,no_term_above_threshold +5156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regulatory interaction tails,False,no_term_above_threshold +5157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-sandwich glycan binders,False,no_term_above_threshold +5158,29104,16.303679,0.72753906,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.71484375,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,9.0,0.0,1.0,Multi-pass transmembrane helix interface,True,assigned_too_few_test_positives +5159,36914,20.753576,0.98046875,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.87597656,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Glycosyltransferase catalytic core activation,True,assigned_too_few_test_positives +5160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SRPBCC helix-grip lipid binders,False,no_term_above_threshold +5161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged intrinsically disordered regions,False,no_term_above_threshold +5162,87276,37.510967,0.6621094,Cell membrane,keyword,88161,Transmembrane helix,0.640625,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7497765667141999,0.5050655224703904,0.11120957022596367,0.5298804780876494,4.541565275759646,10.0,19.0,4.318672403552233,4.3047937797857006e-05,Multipass alpha-helical transmembrane helices,True,assigned_and_evaluated +5163,87413,50.66116,0.9033203,Disulfide bond,keyword,87413,Disulfide bond,0.9033203,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.943357199681782,0.5538977973332246,0.0717766947275144,0.8827160493827161,7.716958818401778,12.0,19.0,7.469821150774178,7.666484699323416e-09,Disulfide-rich secreted peptides,True,assigned_and_evaluated +5164,37468,18.650606,0.95654297,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.92333984,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,18.0,0.0,1.0,CxxC -1 beta-strand context,True,assigned_too_few_test_positives +5165,72011,17.07185,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9038086,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,14.0,14.0,590.3069306930694,4.7603558278022205e-39,ANL AMP-binding adenylation core,True,assigned_too_few_test_positives +5166,38317,16.078615,0.8588867,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8588867,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6963174603174603,0.049958205110429935,0.0031014621178555605,,16.10795270489148,0.0,17.0,0.0,1.0,Disordered N-terminal transcriptional domains,True,assigned_and_evaluated +5167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-entry signal-anchor hairpin,False,no_term_above_threshold +5168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular low-complexity repeats,False,no_term_above_threshold +5169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane segments,False,no_term_above_threshold +5170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transducing coupling helices,False,no_term_above_threshold +5171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted PLAT β-sandwich activation,False,no_term_above_threshold +5172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-cofactor catalytic cores,False,no_term_above_threshold +5173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MmgE/PrpD dehydratase/decarboxylase,False,no_term_above_threshold +5174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic-His phosphate-binding surfaces,False,no_term_above_threshold +5175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-FAD N-terminal linker,False,no_term_above_threshold +5176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site anion-binding loops,False,no_term_above_threshold +5177,45324,23.142199,0.9638672,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9638672,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9995559502664298,0.71,0.002215330084182543,1.0,320.494,15.0,15.0,546.9816513761467,3.1549135532889026e-41,Polysaccharide-binding β-helix repeats,True,assigned_and_evaluated +5178,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial TM hairpin loops,False,no_term_above_threshold +5179,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted anionic-ester remodelers,False,no_term_above_threshold +5180,36091,19.417362,0.9980469,GNAT domain,interpro,85712,3.40.630.30,0.98828125,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,19.0,20.0,358.48069620253165,2.586670040738955e-47,GNAT acetyl-CoA A-motif loop,True,assigned_too_few_test_positives +5181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal DNA/RNA recognition surfaces,False,no_term_above_threshold +5182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PPI domains with flanking IDRs,False,no_term_above_threshold +5183,36091,25.132793,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,14.0,14.0,377.3481012658228,2.6485674118201105e-36,GNAT catalytic α3-helix,True,assigned_too_few_test_positives +5184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix packing motifs,False,no_term_above_threshold +5185,36535,19.874226,0.9350586,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8803711,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9484201157098352,0.8668319549057254,0.004430660168365086,0.9,195.64397222222223,17.0,17.0,89.79066265060241,2.357720211227094e-33,Post-APE kinase loop glycine,True,assigned_and_evaluated +5186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization segments,False,no_term_above_threshold +5187,85664,24.166773,0.9121094,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9121094,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,8.0,15.0,176.6548148148148,9.021456085634026e-17,Nucleotide-sugar donor-binding site,True,assigned_too_few_test_positives +5188,87326,32.84745,0.6660156,Coiled coil,keyword,87326,Coiled coil,0.6660156,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6535096811642274,0.24418720158566753,0.03943287549844927,0.29213483146067415,6.1924776851556365,9.0,18.0,6.303764009304293,5.847544268178684e-06,Extended amphipathic helical repeats,True,assigned_and_evaluated +5189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal uDENN/longin and low-complexity scaffolds,False,no_term_above_threshold +5190,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T-rich low-complexity IDRs,False,no_term_above_threshold +5191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly–aromatic gating motifs,False,no_term_above_threshold +5192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding motif flanks,False,no_term_above_threshold +5193,64148,16.559164,0.67626953,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.671875,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5523258548516062,0.01796777897411577,0.008418254319893664,,2.1343830076094368,15.0,16.0,83.42490671641791,2.688797228425055e-28,S/T-Pro-rich disordered activation tails,True,assigned_and_evaluated +5194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured assembly interface segments,False,no_term_above_threshold +5195,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved N-terminal activation motif,False,no_term_above_threshold +5196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glutamate 5-kinase basic helix,False,no_term_above_threshold +5197,30838,16.539595,0.6977539,heme binding,go_mf,30838,heme binding,0.6977539,98,go,GO:0020037,go_mf:go:GO:0020037,11.0,2257.0,0.7547761677325345,0.0770274911032401,0.004873726185201595,,15.80464067454663,2.0,16.0,15.271772540983608,0.012735400675766138,Amphipathic helical bundle interfaces,True,assigned_and_evaluated +5198,64155,19.11185,0.7709961,Ribonuclease H superfamily,interpro,64155,Ribonuclease H superfamily,0.7709961,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,14.0,17.0,228.3704514363885,1.149317918711881e-31,N-terminal exonuclease-like module,True,assigned_too_few_test_positives +5199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered Ser/Pro-rich C-termini,False,no_term_above_threshold +5200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transferase N-terminal juxtamembrane linker,False,no_term_above_threshold +5201,38878,15.71876,0.9814453,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.9243164,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,1.0,14.0,15.949973247726055,0.09980511500297759,N-terminal edge beta-strand,True,assigned_too_few_test_positives +5202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-binding oxidoreductase cores,False,no_term_above_threshold +5203,64058,24.15603,0.9814453,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.97265625,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9900324820075155,0.44773483892089644,0.006202924235711121,0.21428571428571427,72.18125224603308,18.0,18.0,113.99808795411089,4.371993551442556e-37,Rossmann N-terminal helix hydrophobes,True,assigned_and_evaluated +5204,82764,19.310516,0.98876953,Kelch-type beta propeller,gene3d,63831,F-box-like domain superfamily,0.9003906,38,gene3d,2.120.10.80,gene3d:gene3d:2.120.10.80,,,,,,,,10.0,19.0,287.8850796716562,7.013969803443412e-23,Kelch/WD40 propeller Velcro signal,True,assigned_too_few_test_positives +5205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trp rich glycine acidic surfaces,False,no_term_above_threshold +5206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical assembly cores,False,no_term_above_threshold +5207,50338,17.273788,0.9995117,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9526367,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,15.0,15.0,392.24342105263156,4.6846028532927467e-39,GPCR extracellular loop signature,True,assigned_too_few_test_positives +5208,37894,24.114779,0.9609375,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9609375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,12.0,650.625992063492,1.0290217778680566e-30,NAD(P) cofactor-binding lid,True,assigned_too_few_test_positives +5209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity flanking segments,False,no_term_above_threshold +5210,64058,17.86851,0.87402344,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.85839844,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9492070568753582,0.06013051203791712,0.006202924235711121,,9.693897547827067,0.0,17.0,0.0,1.0,Active-site proximal beta-strand,True,assigned_and_evaluated +5211,85672,24.226738,0.6328125,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.6328125,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.664790634849167,0.31244233992659987,0.01595037660611431,0.3333333333333333,19.588398922620442,20.0,20.0,40.01409395973155,3.4248579225102187e-32,Pre-Walker A P-loop segment,True,assigned_and_evaluated +5212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted/periplasmic low-complexity regions,False,no_term_above_threshold +5213,36409,17.973848,0.9555664,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.9555664,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,17.0,0.0,1.0,Beta-strand exits and N-caps,True,assigned_too_few_test_positives +5214,84152,26.843807,0.98535156,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.98535156,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,Enzyme alpha/beta core scaffold,True,assigned_too_few_test_positives +5215,36010,19.920782,0.9863281,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9555664,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,18.0,0.0,1.0,Alpha/beta-hydrolase cap/lid segment,True,assigned_too_few_test_positives +5216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal helical basic-polar-aromatic motif,False,no_term_above_threshold +5217,46284,16.38658,0.99072266,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.99072266,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,15.0,15.0,1192.42,2.062380056822838e-46,Binding-cleft rim anchor,True,assigned_too_few_test_positives +5218,50338,15.7983465,0.9580078,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6748047,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix interfacial anchors,True,assigned_too_few_test_positives +5219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal structured domain activation,False,no_term_above_threshold +5220,85649,40.413498,0.9736328,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96777344,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8883753065275777,0.6999247552367359,0.0101905183872397,0.782608695652174,68.68392054649186,17.0,17.0,110.61410018552876,7.110790058883305e-35,SAM MTase active-site helix,True,assigned_and_evaluated +5221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-GGDEF DxxTGL motif,False,no_term_above_threshold +5222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid processing domain activation,False,no_term_above_threshold +5223,64016,16.62671,0.765625,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.765625,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8961587301587302,0.05971072912603623,0.0031014621178555605,,19.252445091066253,0.0,20.0,0.0,1.0,GDSL/SGNH nucleophile elbow,True,assigned_and_evaluated +5224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting signals,False,no_term_above_threshold +5225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand start hydrophobics,False,no_term_above_threshold +5226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular acidic low-complexity segments,False,no_term_above_threshold +5227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zymogen propeptide activation,False,no_term_above_threshold +5228,87276,39.583607,0.6791992,Cell membrane,keyword,88161,Transmembrane helix,0.64501953,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7712132526722622,0.5184924749034677,0.11120957022596367,0.5896414342629482,4.6623008599885525,10.0,20.0,4.102738783374622,7.607962364733714e-05,Membrane-helix boundary elements,True,assigned_and_evaluated +5229,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse mid-chain catalytic activation,False,no_term_above_threshold +5230,55054,26.226406,1.0,HAD superfamily,interpro,55054,HAD superfamily,1.0,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8981349911190054,0.49806211363588415,0.002215330084182543,0.8,224.82523809523812,19.0,19.0,334.9494382022472,1.6151862494317167e-47,Active site rim cap helix,True,assigned_and_evaluated +5231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent surface loops,False,no_term_above_threshold +5232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic helices,False,no_term_above_threshold +5233,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core helix signal,False,no_term_above_threshold +5234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted loops and propeptides,False,no_term_above_threshold +5235,37894,15.879227,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.81152344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,8.0,709.7738095238095,3.1343957826349425e-23,Rossmann oxidoreductase active-site helix,True,assigned_too_few_test_positives +5236,27733,18.50283,0.7729492,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.60791016,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.6596278852516445,0.05740786452700772,0.0101905183872397,,5.633458705976365,5.0,18.0,14.92017017017017,2.8838563836754264e-05,Intrinsically disordered activation domains,True,assigned_and_evaluated +5237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ion-transport transmembrane helices,False,no_term_above_threshold +5238,64585,17.349924,0.9160156,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.8588867,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,20.0,0.0,1.0,Amphipathic repeat anchoring signal,True,assigned_too_few_test_positives +5239,29104,23.50674,0.8203125,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.81640625,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,10.0,10.0,428.9280575539568,1.0967045620706512e-26,Juxtamembrane amphipathic loops,True,assigned_too_few_test_positives +5240,49045,16.349655,0.98828125,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.91796875,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,2.0,18.0,60.22323232323232,0.000899346894276853,Beta-propeller blade-start N-cap,True,assigned_too_few_test_positives +5241,88058,50.348568,0.81103516,Signal,keyword,88058,Signal,0.81103516,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8036868115482383,0.25760694891193453,0.09127159946832078,,2.822421765506001,1.0,19.0,0.3792081411989187,1.0,Early N-terminal positional signal,True,assigned_and_evaluated +5242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal capping helix/strands,False,no_term_above_threshold +5243,87697,17.612402,0.83691406,Knottin,keyword,87413,Disulfide bond,0.62597656,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9173545120344038,0.08949692628776698,0.017279574656623838,,5.1793477597817965,0.0,17.0,0.0,1.0,Solvent-exposed ectodomain/linker segments,True,assigned_and_evaluated +5244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane coil-to-helix transitions,False,no_term_above_threshold +5245,63831,29.190857,0.9975586,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9975586,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9991115059973344,0.594047619047619,0.002658396101019052,1.0,223.46091269841267,15.0,20.0,184.01543209876544,5.971874513401064e-32,F-box N-terminal amphipathic helix,True,assigned_and_evaluated +5246,45551,16.87122,0.67871094,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.67871094,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,18.0,0.0,1.0,PDE/HD catalytic scaffold,True,assigned_too_few_test_positives +5247,49236,16.27335,0.8276367,C-type lectin fold,interpro,49236,C-type lectin fold,0.8276367,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9981349911190053,0.4009090909090909,0.002215330084182543,0.6,180.97036363636363,0.0,13.0,0.0,1.0,N-terminal extracellular cysteine-rich ectodomains,True,assigned_and_evaluated +5248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T-rich interaction segments,False,no_term_above_threshold +5249,87489,19.263184,0.84277344,GPI-anchor,keyword,87522,Glycoprotein,0.60058594,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.7726349206349207,0.21854531526662674,0.0031014621178555605,0.14285714285714285,70.46525379382523,16.0,18.0,130.85541838134432,1.0237520730194868e-32,First extracellular binding domain,True,assigned_and_evaluated +5250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic/effector domain core,False,no_term_above_threshold +5251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural boundary capping residues,False,no_term_above_threshold +5252,27013,19.934793,0.92626953,side of membrane,go_cc,87760,Membrane,0.6743164,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.7933511032133865,0.026895403732599885,0.002658396101019052,,10.117154370746324,0.0,20.0,0.0,1.0,Terminal transmembrane helix anchors,True,assigned_and_evaluated +5253,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended interaction region activation,False,no_term_above_threshold +5254,36115,18.548538,0.9370117,BTB/POZ domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.87158203,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,14.0,0.0,1.0,AAA+ SRH Arg-finger loop-helix,True,assigned_too_few_test_positives +5255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic active-site loop motifs,False,no_term_above_threshold +5256,39958,16.543453,0.9291992,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.9291992,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9889308455501259,0.12584817490403644,0.002658396101019052,,47.339888459735036,2.0,16.0,59.147817460317455,0.0009258860314117105,Terminal non-globular linear segments,True,assigned_and_evaluated +5257,37341,28.698576,0.9926758,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9902344,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9995349609699385,0.8905972351316355,0.011962782454585734,1.0,74.44733184044819,3.0,20.0,21.812560975609752,0.0006031475402769777,Conserved propeller beta-strand site,True,assigned_and_evaluated +5258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader and TM1,False,no_term_above_threshold +5259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAM-lobe catalytic loop,False,no_term_above_threshold +5260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen Gly–X–Y Y-position detector,False,no_term_above_threshold +5261,87413,40.65168,0.7133789,Disulfide bond,keyword,87413,Disulfide bond,0.7133789,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.7458381213353369,0.29582995958934755,0.0717766947275144,0.21604938271604937,4.121532214772577,13.0,17.0,9.044342275692264,4.0903661007469766e-11,Terminal disulfide beta-strand,True,assigned_and_evaluated +5262,43538,15.752304,0.9995117,Rho GTPase activation protein,interpro,28816,GTPase activator activity,0.88964844,34,ip,IPR008936,interpro:ip:IPR008936,,,,,,,,14.0,17.0,389.6797385620915,5.852016125705135e-35,Small GTPase GAP/GEF helical cores,True,assigned_too_few_test_positives +5263,49116,23.003578,0.96972656,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.96972656,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9980461811722913,0.45939393939393935,0.002215330084182543,0.6,207.37042424242424,9.0,20.0,39.167080291970805,1.098312428765299e-12,HEAT/ARM alpha-solenoid repeats,True,assigned_and_evaluated +5264,36091,18.905079,0.99902344,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9902344,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,20.0,20.0,377.3481012658228,1.1067828780026621e-50,GNAT active site loop,True,assigned_too_few_test_positives +5265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered tails/linkers,False,no_term_above_threshold +5266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytochrome c heme-attachment segments,False,no_term_above_threshold +5267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity regulatory IDRs,False,no_term_above_threshold +5268,36886,15.605191,0.9555664,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,87413,Disulfide bond,0.7783203,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9792407736771899,0.08198317244877938,0.003544528134692069,,23.129502527111885,0.0,12.0,0.0,1.0,Short cysteine metal-binding motifs,True,assigned_and_evaluated +5269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-binding low-complexity IDRs,False,no_term_above_threshold +5270,37071,18.813023,0.75634766,Homeodomain,interpro,37071,Homeodomain,0.75634766,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,20.0,0.0,1.0,Outer-membrane β-barrel loop detector,True,assigned_too_few_test_positives +5271,87697,27.836678,0.95947266,Knottin,keyword,87413,Disulfide bond,0.6386719,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9988497375783219,0.8783298304421123,0.017279574656623838,1.0,50.83052377712429,4.0,17.0,59.44267198404786,1.0579701414960257e-06,Secreted Cys/Gly disulfide frameworks,True,assigned_and_evaluated +5272,61392,27.396677,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9998730158730159,0.9617346938775508,0.0031014621178555605,1.0,310.09074344023315,10.0,10.0,167.4747191011236,1.4100513468805223e-22,LRR inter-repeat junctions,True,assigned_and_evaluated +5273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane cytosolic coiled-coil stalks,False,no_term_above_threshold +5274,36091,15.578483,0.9301758,GNAT domain,interpro,85712,3.40.630.30,0.8959961,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,Active-site glycine-rich loop,True,assigned_too_few_test_positives +5275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass H-box lipid enzymes,False,no_term_above_threshold +5276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic loop–TM helix junction,False,no_term_above_threshold +5277,46277,21.876192,0.89453125,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.89453125,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9405609973285842,0.3449988384962765,0.004873726185201595,0.2727272727272727,70.78748895328147,13.0,19.0,128.68553876805578,1.72133021102381e-25,OB-fold nucleic acid binders,True,assigned_and_evaluated +5278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic strand-helix loop,False,no_term_above_threshold +5279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GOLPH3/VPS74 helix motif,False,no_term_above_threshold +5280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical scaffolds,False,no_term_above_threshold +5281,38873,16.898422,0.9448242,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.89160156,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8876554174067496,0.13181932864309914,0.002215330084182543,,59.503244949494956,5.0,15.0,57.10823754789272,3.7620499356533445e-08,AAA+/RecA PS1 pore-loop module,True,assigned_and_evaluated +5282,45290,16.952356,0.7949219,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7949219,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.8473364870423694,0.17035507870343736,0.0057598582188746125,0.3076923076923077,29.576262510281392,0.0,19.0,0.0,1.0,Helix N-cap/start motif,True,assigned_and_evaluated +5283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,A2M bait-region module,False,no_term_above_threshold +5284,87413,22.772934,0.64208984,Disulfide bond,keyword,87413,Disulfide bond,0.64208984,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6374421756681103,0.16413070842814206,0.0717766947275144,0.06172839506172839,2.286685240261214,7.0,18.0,4.599473208578545,0.0007540417261158168,Glycine-aromatic loop motifs,True,assigned_and_evaluated +5285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multiheme c-type cytochrome detector,False,no_term_above_threshold +5286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenol-linked GT-C TM signature,False,no_term_above_threshold +5287,38317,18.301405,0.7680664,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7680664,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6162222222222221,0.007086732525483076,0.0031014621178555605,,2.2849650442879006,0.0,12.0,0.0,1.0,Noncatalytic partner-docking patches,True,assigned_and_evaluated +5288,48241,22.382063,0.8334961,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.8334961,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,14.0,14.0,387.14935064935065,1.853842982524589e-36,CNB-like sensors and disordered tails,True,assigned_too_few_test_positives +5289,45551,20.171299,0.96533203,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.96533203,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,19.0,0.0,1.0,Death-folds and acidic linkers,True,assigned_too_few_test_positives +5290,38317,16.900341,0.8144531,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8144531,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6065079365079364,0.007320435189287649,0.0031014621178555605,,2.3603174603174604,0.0,12.0,0.0,1.0,Acidic glycine-rich hinge loop,True,assigned_and_evaluated +5291,39958,23.87014,0.9995117,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.9995117,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9977047238264475,0.37661736411736413,0.002658396101019052,1.0,141.67089846881512,4.0,20.0,94.63650793650794,1.7672171227892766e-07,Short disordered polybasic segments,True,assigned_and_evaluated +5292,59218,16.269424,0.7109375,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.7109375,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,0.0,15.0,0.0,1.0,Two-metal phosphoesterase active site,True,assigned_too_few_test_positives +5293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM helix-loop-helix,False,no_term_above_threshold +5294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interaction-mediating elements,False,no_term_above_threshold +5295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal cytosolic segments,False,no_term_above_threshold +5296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helix-start motif,False,no_term_above_threshold +5297,82029,17.56515,0.8613281,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69921875,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,C-terminal transmembrane helix exits,True,assigned_too_few_test_positives +5298,38654,16.495207,0.95996094,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9584961,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,19.0,0.0,1.0,Short amphipathic interface helices,True,assigned_too_few_test_positives +5299,72011,17.023064,0.9926758,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9169922,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,C-terminal modules and anchors,True,assigned_too_few_test_positives +5300,59224,21.682133,0.9814453,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8330078,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,137.37557603686636,1.6332112516921354e-38,Post-Ser active-site helix,True,assigned_and_evaluated +5301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ECL1 of membrane transporters,False,no_term_above_threshold +5302,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global cysteine recognition,False,no_term_above_threshold +5303,46277,18.834473,0.6645508,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.6645508,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.6337731725087024,0.22432374891391285,0.004873726185201595,0.18181818181818182,46.0271546635183,13.0,17.0,143.8250139172388,1.5781698141590733e-26,ssDNA-binding OB-fold domains,True,assigned_and_evaluated +5304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-lining beta-strand segments,False,no_term_above_threshold +5305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic interaction surfaces,False,no_term_above_threshold +5306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop micro-motifs,False,no_term_above_threshold +5307,87852,17.193863,0.9291992,Nucleosome core,keyword,87852,Nucleosome core,0.9291992,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,20.0,0.0,1.0,Broad viral structural/membrane activation,True,assigned_too_few_test_positives +5308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface/appendage assembly domains,False,no_term_above_threshold +5309,45714,17.05315,1.0,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,1.0,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,14.0,14.0,298.105,7.283149953202633e-35,bHLH/HLH C-terminal tail activation,True,assigned_too_few_test_positives +5310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic Asp N-terminal strand,False,no_term_above_threshold +5311,85791,22.166092,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9995117,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,16.0,16.0,648.054347826087,5.3717819825813195e-45,MBL/beta-CASP HxH/HxHxD motif,True,assigned_too_few_test_positives +5312,36876,17.892973,0.9814453,Cytochrome P450,interpro,36876,Cytochrome P450,0.9814453,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,0.0,16.0,0.0,1.0,N-terminal CBM-like Trp motif,True,assigned_and_evaluated +5313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptide and GPI-anchor,False,no_term_above_threshold +5314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site β–α gating loops,False,no_term_above_threshold +5315,81349,15.75873,0.9838867,1.10.287.1490,gene3d,87326,Coiled coil,0.6723633,31,gene3d,1.10.287.1490,gene3d:gene3d:1.10.287.1490,,,,,,,,6.0,18.0,119.72088353413653,1.6577047596142706e-11,Heptad-register coiled-coil detector,True,assigned_too_few_test_positives +5316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trafficking adaptor IDR tails,False,no_term_above_threshold +5317,38317,21.277796,0.7763672,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7763672,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.5416507936507936,0.004032022474645426,0.0031014621178555605,,1.300039246467818,0.0,19.0,0.0,1.0,GGDEF-like helical domain cores,True,assigned_and_evaluated +5318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs with helices,False,no_term_above_threshold +5319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2 domains with acidic linkers,False,no_term_above_threshold +5320,36914,19.198288,0.89453125,Glycosyltransferase 2-like,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8496094,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,16.0,0.0,1.0,GHKL ATPase GI(P) loop,True,assigned_too_few_test_positives +5321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-start leader regions,False,no_term_above_threshold +5322,85672,28.177896,0.6899414,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.67822266,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6053704537495623,0.20321272677830055,0.01595037660611431,0.19444444444444445,12.740309009406232,14.0,14.0,40.01409395973155,9.778128717856954e-23,Helicase pre-P-loop region,True,assigned_and_evaluated +5323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/polar IDR hotspots,False,no_term_above_threshold +5324,85649,35.266796,0.7416992,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7368164,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8459966525242303,0.6075304339701011,0.0101905183872397,0.6956521739130435,59.61722562915296,7.0,15.0,51.619913419913416,6.11852730568036e-11,SAM-dependent methyltransferase catalytic core,True,assigned_and_evaluated +5325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory domains and tails,False,no_term_above_threshold +5326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved core landmark residues,False,no_term_above_threshold +5327,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic α/β cofactor pocket scaffold,False,no_term_above_threshold +5328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glucan-binding CBM domains,False,no_term_above_threshold +5329,81858,17.580017,0.8154297,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8154297,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,7.0,19.0,96.34048938134809,1.1674019627046442e-12,Disordered cytosolic C-tail phospho-hubs,True,assigned_too_few_test_positives +5330,88058,32.521378,0.70214844,Signal,keyword,88058,Signal,0.70214844,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6978255930093301,0.13689379559823656,0.09127159946832078,,1.4998509546855334,2.0,20.0,0.7204954682779456,1.0,Low-complexity disordered N-termini,True,assigned_and_evaluated +5331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate binding cleft loops,False,no_term_above_threshold +5332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Energy-coupled motor/scaffold domains,False,no_term_above_threshold +5333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail micro-motif,False,no_term_above_threshold +5334,48767,16.935425,0.9604492,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9604492,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,7.0,0.0,1.0,TF dimerization regulatory helices,True,assigned_too_few_test_positives +5335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SEA domain autoproteolysis serine,False,no_term_above_threshold +5336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CXXCH heme‑c attachment motif,False,no_term_above_threshold +5337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/RGG-rich low-complexity IDRs,False,no_term_above_threshold +5338,64058,18.055063,0.8491211,NAD(P)-binding domain superfamily,interpro,87873,Oxidoreductase,0.74316406,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9130787847907778,0.07340369071381726,0.006202924235711121,,11.833723567220398,0.0,19.0,0.0,1.0,Basic/polar N-terminal segments,True,assigned_and_evaluated +5339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short ordered residue clusters,False,no_term_above_threshold +5340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic glycan-binding proteins,False,no_term_above_threshold +5341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular cofactor proximal loops,False,no_term_above_threshold +5342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OMP beta-barrel strand starts,False,no_term_above_threshold +5343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF alpha-helix detector,False,no_term_above_threshold +5344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered short linear motifs,False,no_term_above_threshold +5345,88160,17.470253,0.7583008,Transmembrane beta strand,keyword,25167,cell outer membrane,0.66308594,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,18.0,209.02723840345197,1.986057124442724e-28,Outer membrane β-barrel proteins,True,assigned_too_few_test_positives +5346,88252,16.708984,0.9042969,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.88964844,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.9084551047875409,0.06116564487693008,0.012405848471422242,,4.930387874543971,0.0,17.0,0.0,1.0,Polar junctional loop clusters,True,assigned_and_evaluated +5347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma70 domain-2 basic helix,False,no_term_above_threshold +5348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal assembly helix,False,no_term_above_threshold +5349,87276,28.391773,0.60791016,Cell membrane,keyword,88161,Transmembrane helix,0.60058594,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6210859453511974,0.27655226432347174,0.11120957022596367,0.26693227091633465,2.486766775211457,8.0,12.0,5.470318377832829,2.8247377570177352e-05,Juxtamembrane helix-capping segments,True,assigned_and_evaluated +5350,86130,26.025328,0.89501953,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,86130,Zn(2)-C6 fungal-type DNA-binding domain,0.89501953,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.991936507936508,0.18497964813754286,0.0031014621178555605,,59.64272369234775,0.0,19.0,0.0,1.0,Coiled coil heptad repeat,True,assigned_and_evaluated +5351,48767,18.99275,0.9863281,DNA-binding pseudobarrel domain superfamily,interpro,88263,Zinc-finger,0.64404297,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,16.0,0.0,1.0,Cys/His-rich DNA-binding cores,True,assigned_too_few_test_positives +5352,29104,17.97057,0.82470703,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.64990234,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,1.0,14.0,30.6377183967112,0.05343011171300564,Cytoplasmic TM entry capping motifs,True,assigned_too_few_test_positives +5353,85664,18.792313,0.93115234,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8774414,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,11.0,0.0,1.0,SDR hydrophobic lid helices,True,assigned_too_few_test_positives +5354,37020,17.195227,0.9838867,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9770508,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,6.0,19.0,257.9134823359769,1.649645089769944e-13,Glycosyltransferase C-terminal regulatory amphipathic tail,True,assigned_too_few_test_positives +5355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse internal midchain activation,False,no_term_above_threshold +5356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent beta-barrel loops,False,no_term_above_threshold +5357,43643,18.345045,0.98583984,Phosphopantetheine binding ACP domain,interpro,37071,Homeodomain,0.87158203,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,0.9958864664747018,0.41816764282351326,0.0057598582188746125,0.38461538461538464,72.60033614251303,0.0,14.0,0.0,1.0,Catalytic Nudix box helix,True,assigned_and_evaluated +5358,52941,24.200901,0.92041016,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.85595703,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,17.0,260.353711790393,4.679078553617228e-41,MFS transmembrane helix bundle,True,assigned_too_few_test_positives +5359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic structural segment activation,False,no_term_above_threshold +5360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface-lining microcore segment,False,no_term_above_threshold +5361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site acidic metal-chelating motifs,False,no_term_above_threshold +5362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RTX C-terminal secretion signal,False,no_term_above_threshold +5363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Second-messenger and two-component signaling,False,no_term_above_threshold +5364,47529,17.935162,0.6821289,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6821289,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7130047969656403,0.3099771774848619,0.007089056269384138,0.25,43.726155598958336,17.0,17.0,77.32944228274968,2.872750145145074e-32,Disordered phospho-rich receptor tails,True,assigned_and_evaluated +5365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Alpha-glucan metabolism, binding, regulation",False,no_term_above_threshold +5366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T/P-rich disordered regions,False,no_term_above_threshold +5367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC Nucleotide-Binding Domain,False,no_term_above_threshold +5368,64003,19.918724,0.99560547,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.88671875,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,16.0,16.0,130.4617067833698,5.252801912935239e-34,C2H2 pre-Cys1 residue marker,True,assigned_and_evaluated +5369,46581,16.028175,0.6254883,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.6254883,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,2.0,17.0,20.390218878248973,0.007342286610599802,Bacterial SPOR domain detector,True,assigned_too_few_test_positives +5370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AFP-like beta-sandwich domain,False,no_term_above_threshold +5371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent metal-binding scaffolds,False,no_term_above_threshold +5372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HAMP/coiled-coil signal linkers,False,no_term_above_threshold +5373,87413,16.575994,0.6074219,Disulfide bond,keyword,88058,Signal,0.6064453,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5652420519166741,0.10645149595761358,0.0717766947275144,0.024691358024691357,1.4830927554094682,4.0,19.0,2.4899403835913927,0.11591908021070414,Disordered low-complexity segments,True,assigned_and_evaluated +5374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory surface binding scaffolds,False,no_term_above_threshold +5375,88160,16.964682,0.8754883,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7524414,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,18.0,257.2642934196332,2.1827294665727175e-37,Outer-membrane beta-barrel strands,True,assigned_too_few_test_positives +5376,36668,20.940132,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,17.0,17.0,532.3303571428571,3.538165212749175e-46,Adenylate-forming AMP-binding core,True,assigned_too_few_test_positives +5377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +5378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity linkers and tails,False,no_term_above_threshold +5379,27932,37.491287,0.96240234,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.9165039,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9982746580125703,0.9052037035608629,0.01949490474080638,0.9772727272727273,46.432835430383356,16.0,16.0,103.50868055555556,2.0382447968559693e-32,Disordered basic N-terminal tails,True,assigned_and_evaluated +5380,38873,18.889013,0.98828125,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95166016,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9979129662522203,0.4388235294117647,0.002215330084182543,0.6,198.0849411764706,9.0,15.0,102.79482758620689,8.331721406267192e-17,Conserved P-loop glycine,True,assigned_and_evaluated +5381,36354,18.431973,0.9584961,RNA recognition motif domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.80126953,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,14.0,0.0,1.0,SF2 helicase motif VI loop,True,assigned_too_few_test_positives +5382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory glycan-binding regions,False,no_term_above_threshold +5383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop motor ATPase core,False,no_term_above_threshold +5384,49116,17.063944,0.85058594,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.85058594,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9825044404973358,0.16719394512771998,0.002215330084182543,,75.4713468306528,3.0,18.0,14.50632603406326,0.0018984803873936752,Genome maintenance helical scaffolds,True,assigned_and_evaluated +5385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent P/L-rich motif,False,no_term_above_threshold +5386,4066,15.901582,0.71777344,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.71777344,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.5924511545293072,0.011772264067346036,0.002215330084182543,,5.314000000000001,0.0,17.0,0.0,1.0,Domain-coupling helical linkers,True,assigned_and_evaluated +5387,59211,18.392694,0.6875,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.6875,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9589426523297491,0.8739855472383515,0.011076650420912717,0.92,78.90341520467837,16.0,16.0,244.34836065573774,2.609530204638983e-38,Pyrophosphorylase N-terminal catalytic core,True,assigned_and_evaluated +5388,59229,28.202986,0.9638672,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9472656,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9455062083998288,0.5604735279253241,0.0101905183872397,0.6956521739130435,54.99951097945463,0.0,15.0,0.0,1.0,Rossmann β1–α1 helix N-cap,True,assigned_and_evaluated +5389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged domain-edge linkers,False,no_term_above_threshold +5390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane glycosylated extracellular loops,False,no_term_above_threshold +5391,85672,17.632092,0.7265625,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7236328,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.812984641552854,0.06817423143322078,0.01595037660611431,,4.274145565132758,2.0,19.0,4.212009890498057,0.13129493792045877,Beta-to-coil junction motifs,True,assigned_and_evaluated +5392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter coupling regions,False,no_term_above_threshold +5393,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann N-terminal α-helix,False,no_term_above_threshold +5394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory low-complexity glyco-like segments,False,no_term_above_threshold +5395,63951,19.826303,0.8720703,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.8154297,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9369563068406485,0.21103316017807078,0.003987594151528578,,52.92242694687842,0.0,18.0,0.0,1.0,Extracellular beta-sheet interaction scaffolds,True,assigned_and_evaluated +5396,88153,15.97964,0.65234375,Transferase,keyword,87601,Hydrolase,0.63427734,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.7712245796354089,0.12991463098845685,0.052724856003544526,,2.464011110428127,4.0,18.0,2.5212390316101065,0.11095475354702117,C-terminal charged micro-motifs,True,assigned_and_evaluated +5397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core hydrophobics and catalytic cysteine,False,no_term_above_threshold +5398,27936,17.42968,0.8388672,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.8388672,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,14.0,14.0,641.0860215053764,1.4363031686193322e-39,Flexible N-terminal targeting segments,True,assigned_too_few_test_positives +5399,87484,16.531082,0.80810547,G-protein coupled receptor,keyword,87484,G-protein coupled receptor,0.80810547,44,keywords,G-protein coupled receptor,keyword:keywords:G-protein coupled receptor,,,,,,,,0.0,16.0,0.0,1.0,Signal-coupling coiled-coil linkers,True,assigned_too_few_test_positives +5400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WxLDPR heme-dioxygenase/portal core,False,no_term_above_threshold +5401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal extramembrane tails,False,no_term_above_threshold +5402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen Gly-X-Y repeat detector,False,no_term_above_threshold +5403,37894,21.543812,1.0,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.84375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,Pre-Rossmann N-terminal tail,True,assigned_too_few_test_positives +5404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site hinge/lid linkers,False,no_term_above_threshold +5405,38873,17.871723,0.9902344,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9580078,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9992451154529307,0.836923076923077,0.002215330084182543,0.8,377.787076923077,14.0,16.0,149.9091235632184,1.7911637581253465e-29,Pre-Walker A strand-loop junction,True,assigned_and_evaluated +5406,-1,,,,,-1,,,0,,,,,,,,,,,,,,,pfkB beta1–beta2 phosphate-binding loop,False,no_term_above_threshold +5407,4066,18.283123,0.83154297,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.83154297,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7881882770870338,0.03786593619523972,0.002215330084182543,,17.092683598531213,3.0,18.0,119.72088353413653,3.982306517830393e-06,Polyanion-binding surface loops,True,assigned_and_evaluated +5408,38317,16.565084,0.87939453,Pentatricopeptide repeat,interpro,87384,DNA-binding,0.60253906,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7674285714285713,0.05179766129787743,0.0031014621178555605,,16.701045935615625,0.0,14.0,0.0,1.0,Plant TF terminal disordered regions,True,assigned_and_evaluated +5409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nudix box catalytic loop,False,no_term_above_threshold +5410,48255,18.340794,0.7602539,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.7602539,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,17.0,17.0,340.69142857142856,5.512047947924061e-43,Adenylate-forming ATP-binding fold,True,assigned_too_few_test_positives +5411,82029,32.52572,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9868164,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,20.0,159.86703470031546,8.643294513004192e-36,MFS TM4/TM10 cytoplasmic gate,True,assigned_too_few_test_positives +5412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding alpha/beta lobe,False,no_term_above_threshold +5413,42054,17.121887,1.0,Radical SAM,interpro,33780,"4 iron, 4 sulfur cluster binding",0.74121094,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,11.0,11.0,677.5113636363636,1.5704835118086414e-31,Radical SAM active-site core,True,assigned_too_few_test_positives +5414,46284,25.316206,0.99658203,FMN-binding split barrel,interpro,46277,"Nucleic acid-binding, OB-fold",0.87158203,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,18.0,0.0,1.0,Short hydrophobic beta-strand motif,True,assigned_too_few_test_positives +5415,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helices and coiled coils,False,no_term_above_threshold +5416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal accessory/targeting regions,False,no_term_above_threshold +5417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycan-binding modules,False,no_term_above_threshold +5418,88009,20.13617,0.63720703,Repeat,keyword,88009,Repeat,0.63720703,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7250372903872374,0.3290496449316074,0.07266282676118742,0.2865853658536585,4.528445418357547,11.0,17.0,5.736549311174284,4.691062098338684e-07,C-terminal interaction modules,True,assigned_and_evaluated +5419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryote-specific N-terminal module detector,False,no_term_above_threshold +5420,87276,42.239464,0.7001953,Cell membrane,keyword,88161,Transmembrane helix,0.6772461,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7788338172732796,0.4860379424794351,0.11120957022596367,0.6135458167330677,4.370468670024243,16.0,18.0,7.293757837110438,6.233534051251394e-13,Loop-to-TM helix junctions,True,assigned_and_evaluated +5421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM6-7 cytosolic loop motif,False,no_term_above_threshold +5422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligase and GTase NTase core,False,no_term_above_threshold +5423,69819,23.337467,0.86572266,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8442383,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,C-terminal appendage detector,True,assigned_too_few_test_positives +5424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal acidic catalytic loops,False,no_term_above_threshold +5425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad integrase block activation,False,no_term_above_threshold +5426,36104,21.831057,0.8803711,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8803711,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Asp-rich isoprenoid enzyme cores,True,assigned_too_few_test_positives +5427,45290,28.505547,0.9692383,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9692383,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.959618812559989,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Kinase catalytic-loop anchor,True,assigned_and_evaluated +5428,87276,35.9359,0.6503906,Cell membrane,keyword,88161,Transmembrane helix,0.6176758,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7264580759712894,0.43983994276318866,0.11120957022596367,0.50199203187251,3.955054784129549,8.0,19.0,3.4549379228417862,0.0018450570866947091,N-terminal signal-anchor helix,True,assigned_and_evaluated +5429,37894,15.820709,0.9404297,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.86816406,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,17.0,17.0,709.7738095238095,2.951243259467613e-48,Reductase C-terminal substrate loop,True,assigned_too_few_test_positives +5430,47529,25.799282,0.96484375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.96484375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9908244087460955,0.4758693048990517,0.007089056269384138,0.375,67.12731382232248,9.0,20.0,34.798249027237354,3.1277705730455488e-12,beta-sandwich aromatic surface patches,True,assigned_and_evaluated +5431,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cas7-like RAMP RNA-binding scaffold,False,no_term_above_threshold +5432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transmembrane signal-anchor helices,False,no_term_above_threshold +5433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2 phosphoinositide membrane targeting,False,no_term_above_threshold +5434,47529,21.42777,0.95654297,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.95654297,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.976642681838465,0.19262707153623096,0.007089056269384138,,27.17245627857958,2.0,12.0,12.88824038045828,0.017248029509196718,Ubiquitin-like β-strand position,True,assigned_and_evaluated +5435,38873,18.70332,0.9526367,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.92626953,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8913854351687389,0.19243440800817851,0.002215330084182543,,86.86489177489179,7.0,19.0,63.11963097398669,2.2171377393875897e-11,Pre-Walker A adenine-sensing motif,True,assigned_and_evaluated +5436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil helices and charged IDRs,False,no_term_above_threshold +5437,87384,23.88072,0.70703125,DNA-binding,keyword,87384,DNA-binding,0.70703125,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.6347019780754721,0.06019106803354066,0.043863535666814356,,1.3722347530474874,1.0,20.0,0.6125025683172386,1.0,Coiled-coils and propeptide spacers,True,assigned_and_evaluated +5438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,T2SS pseudopilin periplasmic domain,False,no_term_above_threshold +5439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV/GAF sensory mini-motifs,False,no_term_above_threshold +5440,87970,15.700886,0.8457031,Protein phosphatase,keyword,87970,Protein phosphatase,0.8457031,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,12.0,13.0,265.86845039018954,1.0096389353035879e-28,PTP superfamily fold recognition,True,assigned_too_few_test_positives +5441,38317,24.538017,0.9790039,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9790039,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9755555555555555,0.0640795553531931,0.0031014621178555605,,20.661079490308115,0.0,11.0,0.0,1.0,ABC transporter H-loop switch,True,assigned_and_evaluated +5442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal catalytic helix hotspot,False,no_term_above_threshold +5443,85664,23.266468,0.85839844,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.85839844,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,19.0,313.79473684210524,5.906101246632783e-44,ADP-heptose GT-B N-lobe loop,True,assigned_too_few_test_positives +5444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Small disordered proteins, distributed activation",False,no_term_above_threshold +5445,87489,19.31476,0.8510742,GPI-anchor,keyword,87522,Glycoprotein,0.7026367,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9802539682539683,0.11251484154245489,0.0031014621178555605,,36.277999623045815,0.0,16.0,0.0,1.0,Repeat-rich extracellular glycoprotein domains,True,assigned_and_evaluated +5446,64058,22.860708,0.95214844,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9428711,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9975160817782307,0.6092324784164678,0.006202924235711121,0.9285714285714286,98.21697884185484,9.0,19.0,53.999094294052526,5.612224809734199e-14,Cofactor-binding hydrophobic cluster,True,assigned_and_evaluated +5447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Caspase-like cysteine protease core,False,no_term_above_threshold +5448,42054,17.316957,0.9980469,Radical SAM,interpro,42054,Radical SAM,0.9980469,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,11.0,11.0,677.5113636363636,1.5704835118086414e-31,Radical SAM accessory regions,True,assigned_too_few_test_positives +5449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DsbD/CcdA cytoplasmic redox loop,False,no_term_above_threshold +5450,72011,16.998577,0.99853516,"AMP-binding enzyme, C-terminal domain superfamily",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.7373047,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,N-terminal hydrophobic helix detector,True,assigned_too_few_test_positives +5451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core macromolecular machine scaffolds,False,no_term_above_threshold +5452,88058,61.351788,0.8457031,Signal,keyword,88058,Signal,0.8457031,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7927970253676871,0.20448952593778247,0.09127159946832078,,2.2404507769008495,7.0,20.0,2.5217341389728096,0.024798531661208274,N-terminal hydrophobic targeting signals,True,assigned_and_evaluated +5453,37341,24.458158,0.99853516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99121094,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 blade-start [G/A]H motif,True,assigned_and_evaluated +5454,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alpha-helical segments,False,no_term_above_threshold +5455,24789,16.472525,0.8666992,nucleosome,go_cc,87162,Antimicrobial,0.6166992,68,go,GO:0000786,go_cc:go:GO:0000786,,,,,,,,5.0,18.0,104.159678546471,2.166125143914293e-09,Disordered polybasic nucleic acid binders,True,assigned_too_few_test_positives +5456,88160,17.554098,0.79345703,Transmembrane beta strand,keyword,25167,cell outer membrane,0.67626953,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,12.0,16.0,217.06674757281553,1.2053969020607763e-26,OM and organelle insertion segments,True,assigned_too_few_test_positives +5457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tat/Sec signal peptides,False,no_term_above_threshold +5458,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal FAD cap subdomain,False,no_term_above_threshold +5459,80926,16.76801,0.83935547,Homeodomain-like,gene3d,87384,DNA-binding,0.65283203,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.8951734539969833,0.03611456457917921,0.0057598582188746125,,6.270044019631345,0.0,15.0,0.0,1.0,NADH-binding Fe-S subunit motif,True,assigned_and_evaluated +5460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting helices,False,no_term_above_threshold +5461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase H-like Mg2+ active-site,False,no_term_above_threshold +5462,63774,25.5205,0.99560547,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.97558594,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,16.0,18.0,162.5657805044308,3.2348326032203938e-34,RBP IDRs and coiled-coils,True,assigned_too_few_test_positives +5463,59224,25.217768,0.7421875,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.7421875,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7114920634920635,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,16.0,16.0,137.37557603686636,2.308526036036146e-34,N-terminal AB-hydrolase cap,True,assigned_and_evaluated +5464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity IDR activation,False,no_term_above_threshold +5465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma factor RNAP/DNA interfaces,False,no_term_above_threshold +5466,59224,17.192604,0.9296875,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.80371094,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9291111111111111,0.024990429940521183,0.0031014621178555605,,8.057628625108045,1.0,17.0,8.080916237462727,0.1879739444796349,LpxK SRGYK loop motif,True,assigned_and_evaluated +5467,37894,19.554447,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.85058594,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,9.0,709.7738095238095,4.424699527134814e-26,SDR substrate-binding helix-coil,True,assigned_too_few_test_positives +5468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase N-terminal capping helices,False,no_term_above_threshold +5469,85649,21.948006,0.9580078,Vaccinia Virus protein VP39,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7788086,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9701646490989063,0.6329098546192881,0.0101905183872397,0.7391304347826086,62.107719211988396,2.0,18.0,12.29045557616986,0.019302395452946822,Acidic cofactor-binding active sites,True,assigned_and_evaluated +5470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular luminal ectodomains,False,no_term_above_threshold +5471,85364,25.486948,0.9194336,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9194336,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Periplasmic SBP aromatic cleft,True,assigned_too_few_test_positives +5472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase catalytic cleft,False,no_term_above_threshold +5473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CENPB HTH and linker,False,no_term_above_threshold +5474,88058,21.675694,0.6347656,Signal,keyword,88058,Signal,0.6347656,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6155912578756277,0.11088983030947716,0.09127159946832078,,1.2149434320800483,6.0,20.0,2.1614864048338367,0.08048950337413811,Disordered Arg–Pro motifs,True,assigned_and_evaluated +5475,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenol-interacting TM helix boundary,False,no_term_above_threshold +5476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +5477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered SLiMs and helices,False,no_term_above_threshold +5478,85672,25.032621,0.796875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.79296875,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6847328530691881,0.06337514942043293,0.01595037660611431,,3.973269784497698,9.0,9.0,40.01409395973155,8.640244049603615e-15,NTPase and phosphate-handling motifs,True,assigned_and_evaluated +5479,85364,21.043524,0.6508789,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.6508789,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,16.0,20.0,240.89292929292932,3.186284787002184e-36,Extracytoplasmic surface signature,True,assigned_too_few_test_positives +5480,81858,16.884905,0.8588867,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.69873047,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,N-terminal signal-anchor start,True,assigned_too_few_test_positives +5481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad globular core activation,False,no_term_above_threshold +5482,88058,35.429688,0.6879883,Signal,keyword,88058,Signal,0.6879883,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7313659450990047,0.30868350388699994,0.09127159946832078,0.2621359223300971,3.382032370257082,5.0,19.0,1.8960407059945936,0.1813522347006305,N-terminal targeting presequences,True,assigned_and_evaluated +5483,85364,24.971361,0.8120117,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8120117,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,11.0,19.0,174.33040935672517,8.48342799084619e-23,N-terminal active-site flank,True,assigned_too_few_test_positives +5484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-bridging lipid-transfer scaffolds,False,no_term_above_threshold +5485,47529,23.313955,0.8881836,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8881836,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8545152833556449,0.16563753871255768,0.007089056269384138,0.0625,23.36524530464017,4.0,17.0,18.195162890058747,0.00010602306835956829,Exposed acidic/polar SLiMs,True,assigned_and_evaluated +5486,49116,24.545364,0.9819336,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9819336,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,20.0,20.0,87.03795620437957,8.990576307619231e-39,HEAT/ARM helix caps and turns,True,assigned_and_evaluated +5487,88164,16.34554,0.74853516,Transposition,keyword,46274,Ribonuclease H-like superfamily,0.6777344,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.6878330373001776,0.018818375539687016,0.002215330084182543,,8.49461471861472,0.0,19.0,0.0,1.0,Mg2+-dependent nuclease active sites,True,assigned_and_evaluated +5488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal catalytic core regions,False,no_term_above_threshold +5489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Copper-binding and cupredoxin domains,False,no_term_above_threshold +5490,85672,23.931314,0.81591797,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8051758,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.879389914452949,0.10738002015418673,0.01595037660611431,,6.732130707999985,0.0,14.0,0.0,1.0,Aromatic-Gly-Acidic cofactor-binding loops,True,assigned_and_evaluated +5491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich regulatory IDRs,False,no_term_above_threshold +5492,-1,,,,,-1,,,0,,,,,,,,,,,,,,,USP/UBP deubiquitinase core,False,no_term_above_threshold +5493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-domain N-glycosylation loop,False,no_term_above_threshold +5494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Disordered, signal, and transmembrane regions",False,no_term_above_threshold +5495,87326,30.60227,0.69140625,Coiled coil,keyword,87326,Coiled coil,0.69140625,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.688609084124549,0.20402937090593698,0.03943287549844927,0.1797752808988764,5.174093147580897,17.0,18.0,11.907109795352552,7.798097521564164e-18,Elongated coiled-coil scaffolds,True,assigned_and_evaluated +5496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide-loop N-terminal helix motif,False,no_term_above_threshold +5497,87697,22.429935,0.9394531,Knottin,keyword,87413,Disulfide bond,0.83447266,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9941157429886014,0.5564473394140749,0.017279574656623838,1.0,32.20260628352736,4.0,20.0,50.52627118644069,2.1192512313778267e-06,Disulfide-rich secreted peptides,True,assigned_and_evaluated +5498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GIY-YIG nuclease catalytic motif,False,no_term_above_threshold +5499,12207,16.439817,0.78759766,transposition,go_bp,88164,Transposition,0.7319336,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,0.0,16.0,0.0,1.0,Zinc-coordinated DNA-binding cores,True,assigned_too_few_test_positives +5500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic binding pocket residues,False,no_term_above_threshold +5501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Neprilysin M13 domain activation,False,no_term_above_threshold +5502,36272,15.839051,0.9760742,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9760742,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,20.0,0.0,1.0,Short low-complexity interaction motifs,True,assigned_too_few_test_positives +5503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine esterase/acyltransferase C-terminus,False,no_term_above_threshold +5504,29104,16.976871,0.7368164,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.7368164,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,12.0,0.0,1.0,P-loop K+ selectivity filter,True,assigned_too_few_test_positives +5505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HD-domain LGxxDA helix activation,False,no_term_above_threshold +5506,87697,21.283484,0.93603516,Knottin,keyword,87413,Disulfide bond,0.80859375,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9846593142355089,0.3355179995007962,0.017279574656623838,,19.41702884290505,0.0,18.0,0.0,1.0,Cysteine-rich extracellular repeat modules,True,assigned_and_evaluated +5507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic N-termini and Kazal motifs,False,no_term_above_threshold +5508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad N-terminal secondary-structure activation,False,no_term_above_threshold +5509,87326,32.681202,0.7006836,Coiled coil,keyword,87326,Coiled coil,0.7006836,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7434102782039056,0.24312758978415838,0.03943287549844927,0.12359550561797752,6.165606406099387,18.0,20.0,11.346775216747726,6.031390779229954e-18,Coiled-coil heptad stripe,True,assigned_and_evaluated +5510,36010,15.798477,0.99609375,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.94921875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,15.0,20.0,382.18589743589746,8.893166111167196e-37,Alpha/beta hydrolase lid motif,True,assigned_too_few_test_positives +5511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme N-terminal motifs and leaders,False,no_term_above_threshold +5512,8087,17.1575,0.7739258,DNA transposition,go_bp,88163,Transposable element,0.6586914,35,go,GO:0006313,go_bp:go:GO:0006313,,,,,,,,1.0,17.0,55.66853408029878,0.030071593797665545,Polybasic disordered nucleic-acid tails,True,assigned_too_few_test_positives +5513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,dUTPase catalytic domain,False,no_term_above_threshold +5514,85682,17.851685,0.8779297,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8779297,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.955537634408602,0.14174630297941615,0.011076650420912717,,12.796856232981689,6.0,14.0,43.82822837539818,4.8880683386536015e-09,ALDH helical region signature,True,assigned_and_evaluated +5515,46284,16.64235,0.99853516,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.99853516,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,5.0,16.0,372.63125,3.2052227323317367e-12,Aromatic helix-beta junction motif,True,assigned_too_few_test_positives +5516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-assisted anion-binding catalytic sites,False,no_term_above_threshold +5517,36010,16.904339,0.9980469,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9682617,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,19.0,20.0,484.1021367521368,1.4108077567077888e-49,ABH core beta-strand loop,True,assigned_too_few_test_positives +5518,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical interaction scaffolds,False,no_term_above_threshold +5519,69819,24.592596,0.94189453,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.9116211,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,19.0,19.0,419.86619718309856,3.4794486095487155e-49,NTPase N-terminal RFxN patch,True,assigned_too_few_test_positives +5520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial S1/KH RNA-binding domains,False,no_term_above_threshold +5521,4066,21.022842,0.9013672,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9013672,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7937833037300178,0.48421946536700633,0.002215330084182543,0.6,218.57666666666668,0.0,13.0,0.0,1.0,Nucleic-acid enzyme regulatory interfaces,True,assigned_and_evaluated +5522,87409,19.49626,0.84228516,Dioxygenase,keyword,87409,Dioxygenase,0.84228516,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,13.0,17.0,214.04943385805024,8.810938420668386e-29,2OG oxygenase catalytic core,True,assigned_too_few_test_positives +5523,38873,15.740706,0.80908203,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.66796875,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.6940053285968029,0.40132919805050954,0.002215330084182543,0.4,181.16000000000003,4.0,8.0,85.66235632183908,1.54655154615122e-07,AAA+ ATPase noncatalytic regions,True,assigned_and_evaluated +5524,45290,26.917599,0.81396484,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.81396484,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.8030988619223912,0.314910565605505,0.0057598582188746125,0.15384615384615385,54.67331896704806,15.0,16.0,68.83582204433498,4.67155893575084e-27,Conserved kinase NTP-binding cores,True,assigned_and_evaluated +5525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like regulatory IDRs,False,no_term_above_threshold +5526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal charged helix motif,False,no_term_above_threshold +5527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GatB-like C-terminal domain,False,no_term_above_threshold +5528,85672,16.984255,0.6586914,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.65234375,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6748211516333985,0.044106407574013046,0.01595037660611431,,2.7652267192929845,0.0,16.0,0.0,1.0,Juxtamembrane anchoring scaffold,True,assigned_and_evaluated +5529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory domains/tails,False,no_term_above_threshold +5530,38317,19.183264,0.9560547,Pentatricopeptide repeat,interpro,88154,Transit peptide,0.94970703,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9116190476190476,0.089536475318764,0.0031014621178555605,,28.869117827778624,0.0,19.0,0.0,1.0,Mitochondrial targeting presequence,True,assigned_and_evaluated +5531,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme cores and TM loops,False,no_term_above_threshold +5532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix packing interface,False,no_term_above_threshold +5533,87346,17.7453,0.6166992,Copper,keyword,87346,Copper,0.6166992,76,keywords,Copper,keyword:keywords:Copper,,,,,,,,14.0,18.0,158.80783866057837,3.6288633014982115e-29,Disordered copper-binding tails/loops,True,assigned_too_few_test_positives +5534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GOGAT dual-site FMN motif,False,no_term_above_threshold +5535,58239,37.97744,0.6953125,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6953125,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7094440685611186,0.340461153815324,0.017722640673460344,0.425,19.210520604029657,15.0,15.0,35.851473241130485,1.3063198800490947e-23,BY-kinase DxDxR switch region,True,assigned_and_evaluated +5536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse non-TM helix N-cap selector,False,no_term_above_threshold +5537,64058,26.454721,0.95947266,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.94921875,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9996178587351124,0.8939360242931672,0.006202924235711121,1.0,144.1152576306913,15.0,15.0,113.99808795411089,4.589611073054062e-31,SDR DAVxHFA beta-strand motif,True,assigned_and_evaluated +5538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic internal beta-strand motifs,False,no_term_above_threshold +5539,64599,21.265352,0.9980469,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.9980469,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,18.0,18.0,662.4555555555555,3.0663272748226545e-50,J-domain Hsp70 co-chaperones,True,assigned_too_few_test_positives +5540,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exoplasmic β‑sandwich adhesive/cofactor surfaces,False,no_term_above_threshold +5541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-rich/metal motifs and UbiC,False,no_term_above_threshold +5542,63831,31.342155,0.9970703,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9970703,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9991115059973346,0.6051587301587302,0.002658396101019052,1.0,227.64054232804233,13.0,20.0,159.4800411522634,1.4929381791819601e-26,F-box Skp1-binding junction,True,assigned_and_evaluated +5543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Termini-enriched recognition/catalytic domains,False,no_term_above_threshold +5544,64016,20.43524,0.67333984,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.67333984,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.4931111111111111,0.0031014621178555605,0.0031014621178555605,,1.0,0.0,13.0,0.0,1.0,ABC NBD switch motifs,True,assigned_and_evaluated +5545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Vault and Band-7 scaffolds,False,no_term_above_threshold +5546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cytochrome c docking surface,False,no_term_above_threshold +5547,87276,26.171444,0.60546875,Cell membrane,keyword,87276,Cell membrane,0.60546875,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6375604262908485,0.3144962533391851,0.11120957022596367,0.30677290836653387,2.827960333810919,8.0,15.0,4.376254702266263,0.0002552295022871866,Generic transmembrane helix signature,True,assigned_and_evaluated +5548,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ion channel cytosolic regulatory domains,False,no_term_above_threshold +5549,63951,15.706647,0.94873047,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.93652344,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9693554764729142,0.09353703416797127,0.003987594151528578,,23.457009568567905,1.0,13.0,12.395218295218296,0.12668759423574874,Soluble β-strand/turn motifs,True,assigned_and_evaluated +5550,36272,15.805275,0.87841797,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.87841797,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,20.0,0.0,1.0,Outer-membrane beta-barrel loops,True,assigned_too_few_test_positives +5551,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate binding active site,False,no_term_above_threshold +5552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal non-TM functional patches,False,no_term_above_threshold +5553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical transmembrane segments,False,no_term_above_threshold +5554,46079,20.342142,0.76416016,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.76416016,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.7130296174413822,0.039935102617384255,0.0057598582188746125,,6.93334820057202,5.0,17.0,27.399356617647058,1.5030628753796852e-06,Alpha-solenoid scaffold helices,True,assigned_and_evaluated +5555,85664,22.95512,0.97998047,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.97998047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +5556,59229,29.667929,0.8901367,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8901367,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7221205869759838,0.28151193638818683,0.0101905183872397,0.21739130434782608,27.624888714266852,17.0,17.0,106.27629233511585,1.3819031749869367e-34,Proline-anchored SAM-binding loop,True,assigned_and_evaluated +5557,45290,32.7102,0.9707031,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9707031,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9608014534485123,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,13.0,13.0,73.42487684729065,1.5015230993598282e-24,VAIK Lys β3–αC loop,True,assigned_and_evaluated +5558,87317,19.539906,0.68115234,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.68115234,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.6428073404730031,0.05534666095447504,0.007089056269384138,,7.807338360890635,0.0,19.0,0.0,1.0,Secreted acidic disordered regions,True,assigned_and_evaluated +5559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered terminal linkers,False,no_term_above_threshold +5560,45714,15.579182,0.7368164,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.7368164,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,16.0,0.0,1.0,HAMP connector/hinge loop,True,assigned_too_few_test_positives +5561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-level binding interfaces,False,no_term_above_threshold +5562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Retrotransposon capsid N-proximal segment,False,no_term_above_threshold +5563,-1,,,,,-1,,,0,,,,,,,,,,,,,,,eIF3d core and RNA gate,False,no_term_above_threshold +5564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long hydrophobic transmembrane helices,False,no_term_above_threshold +5565,37894,17.956331,0.9785156,Short-chain dehydrogenase/reductase SDR,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.69189453,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,HATPase_c helix–β hinge loops,True,assigned_too_few_test_positives +5566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved KPHMT N-terminal helix motif,False,no_term_above_threshold +5567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short envelope and sensor helices,False,no_term_above_threshold +5568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic alpha-helical scaffolds,False,no_term_above_threshold +5569,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C lumenal catalytic loop,False,no_term_above_threshold +5570,4066,22.607307,0.9511719,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9511719,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.794316163410302,0.48421946536700633,0.002215330084182543,0.6,218.57666666666668,11.0,19.0,415.8725428027901,4.670945755021222e-27,Nuclease catalytic loop motifs,True,assigned_and_evaluated +5571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic beta-strand boundary,False,no_term_above_threshold +5572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil boundary at interfaces,False,no_term_above_threshold +5573,48255,17.769953,0.74853516,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.74853516,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,0.0,12.0,0.0,1.0,Deacetylase-like metallo-hydrolase core,True,assigned_too_few_test_positives +5574,38654,16.54133,0.96240234,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.96191406,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,17.0,0.0,1.0,Compact structured microdomain cores,True,assigned_too_few_test_positives +5575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-binding alpha/beta catalytic loop,False,no_term_above_threshold +5576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand N-cap microsegments,False,no_term_above_threshold +5577,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic helix scaffolds,False,no_term_above_threshold +5578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long low-complexity IDRs,False,no_term_above_threshold +5579,85672,25.449577,0.6616211,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.6616211,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6146943318825353,0.1672272662074416,0.01595037660611431,0.16666666666666666,10.48422055083877,14.0,14.0,40.01409395973155,9.778128717856954e-23,Noncatalytic NTPase coupling linkers,True,assigned_and_evaluated +5580,46933,18.613508,0.7104492,"Zinc finger, NHR/GATA-type",interpro,64148,Winged helix DNA-binding domain superfamily,0.6748047,49,ip,IPR013088,interpro:ip:IPR013088,,,,,,,,0.0,15.0,0.0,1.0,Post-HTH hinge helix detector,True,assigned_too_few_test_positives +5581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic acyltransferase C-terminal helix,False,no_term_above_threshold +5582,46932,23.54439,0.8544922,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.8544922,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.8964396973742768,0.800886132033673,0.004430660168365086,0.8,180.76,17.0,17.0,108.20508166969147,1.0262878880954455e-34,TF IDRs flanking C2H2,True,assigned_and_evaluated +5583,50806,21.751907,0.99853516,"Homeobox, conserved site",interpro,87384,DNA-binding,0.68066406,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,Conserved HTH aromatic residue,True,assigned_too_few_test_positives +5584,15821,16.156597,0.70410156,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.70410156,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,18.0,0.0,1.0,Regulatory TF/cofactor core domains,True,assigned_too_few_test_positives +5585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and transmembrane helices,False,no_term_above_threshold +5586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HisKA DHp H+10 hotspot,False,no_term_above_threshold +5587,49045,18.828058,0.99658203,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8691406,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,5.0,15.0,180.66969696969696,1.219887648876518e-10,Beta-propeller blade-entry motif,True,assigned_too_few_test_positives +5588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal acidic disordered regions,False,no_term_above_threshold +5589,48767,22.0372,0.99316406,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.9848633,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,19.0,0.0,1.0,OB-fold nucleic acid-binding surface,True,assigned_too_few_test_positives +5590,64475,18.13431,0.9794922,ACP-like superfamily,interpro,63774,RNA-binding domain superfamily,0.84521484,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9882078705608117,0.21083547627863208,0.0057598582188746125,,36.604282304682506,0.0,15.0,0.0,1.0,Beta-strand capping loop motif,True,assigned_and_evaluated +5591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket-edge residues,False,no_term_above_threshold +5592,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal functional onset detector,False,no_term_above_threshold +5593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta core beta-loop junctions,False,no_term_above_threshold +5594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic loop-to-helix entries,False,no_term_above_threshold +5595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Primase TOPRIM-adjacent helix,False,no_term_above_threshold +5596,45290,27.212425,0.7944336,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7944336,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7665226929932812,0.4424468128125127,0.0057598582188746125,0.5384615384615384,76.81557357829547,14.0,15.0,68.52988505747128,3.0474954144632634e-25,Kinase ATP-binding N-lobe,True,assigned_and_evaluated +5597,36409,30.783112,1.0,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",1.0,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,13.0,0.0,1.0,Beta-strand N-cap detector,True,assigned_too_few_test_positives +5598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity region detector,False,no_term_above_threshold +5599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C active-site β–α segments,False,no_term_above_threshold +5600,46919,18.123875,0.80615234,"Tachykinin/Neurokinin-like, conserved site",interpro,46919,"Tachykinin/Neurokinin-like, conserved site",0.80615234,32,ip,IPR013055,interpro:ip:IPR013055,,,,,,,,0.0,18.0,0.0,1.0,SLiM-rich low-complexity disordered regions,True,assigned_too_few_test_positives +5601,87697,20.36298,0.8745117,Knottin,keyword,87413,Disulfide bond,0.64746094,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8869101292455667,0.06771621030819999,0.017279574656623838,,3.9188586324514714,0.0,17.0,0.0,1.0,Hydrophobic beta-strand residues,True,assigned_and_evaluated +5602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic coiled-coil initiators,False,no_term_above_threshold +5603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat-position pivot motif,False,no_term_above_threshold +5604,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site strand-edge loops,False,no_term_above_threshold +5605,38654,21.59369,0.9980469,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9980469,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,18.0,0.0,1.0,FHA phosphothreonine-binding domain,True,assigned_too_few_test_positives +5606,37446,19.682384,0.8154297,F-box domain,interpro,37446,F-box domain,0.8154297,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.6616507936507936,0.007862298064356775,0.0031014621178555605,,2.535029533036177,0.0,17.0,0.0,1.0,Conserved DNA-interaction surfaces,True,assigned_and_evaluated +5607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helix hotspots,False,no_term_above_threshold +5608,82029,18.943975,0.9848633,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9746094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,19.0,0.0,1.0,Kinase activation loop phosphosite,True,assigned_too_few_test_positives +5609,64058,17.159426,0.8383789,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.72216797,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9142411311381442,0.060647849502910654,0.006202924235711121,,9.77729973771924,1.0,18.0,6.333227108561716,0.2335014920738494,Short hydrophobic beta-strands,True,assigned_and_evaluated +5610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prion-like low-complexity IDRs,False,no_term_above_threshold +5611,37020,18.189249,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.97021484,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,17.0,768.6833199033038,1.7917833648140597e-45,Donor nucleotide-sugar binding pocket,True,assigned_too_few_test_positives +5612,82107,19.550058,0.9633789,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.96240234,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,18.0,0.0,1.0,Kinase C-terminal regulatory tail,True,assigned_too_few_test_positives +5613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Junction loops flanking ligand pockets,False,no_term_above_threshold +5614,52270,18.154306,0.8251953,"WD40 repeat, conserved site",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7397461,43,ip,IPR019775,interpro:ip:IPR019775,,,,,,,,11.0,17.0,176.9646519158122,4.163569535429357e-23,Beta-propeller scaffolds and IDRs,True,assigned_too_few_test_positives +5615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regional activation,False,no_term_above_threshold +5616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly interface helices,False,no_term_above_threshold +5617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand N-cap glycine motif,False,no_term_above_threshold +5618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM boundary interfacial caps,False,no_term_above_threshold +5619,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycan binding surfaces,False,no_term_above_threshold +5620,36535,17.015608,0.8354492,Protein kinase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6982422,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8917222963951935,0.20550698847341492,0.004430660168365086,,46.38292729844975,0.0,7.0,0.0,1.0,ABC NBD Q-loop,True,assigned_and_evaluated +5621,36104,21.257076,0.8027344,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8027344,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Upstream activation cluster in CoA-transferases,True,assigned_too_few_test_positives +5622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like disordered regulatory regions,False,no_term_above_threshold +5623,88164,21.61037,0.8828125,Transposition,keyword,88164,Transposition,0.8828125,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.896891651865009,0.64377639935017,0.002215330084182543,0.8,290.6006666666667,3.0,19.0,114.80295250320924,4.54597246245042e-06,Hydrophobic aromatic alpha-helix,True,assigned_and_evaluated +5624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix–juxtamembrane interface,False,no_term_above_threshold +5625,45714,16.277134,0.73779297,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.73779297,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,17.0,0.0,1.0,Pilin-like post-TM helix start,True,assigned_too_few_test_positives +5626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic interaction scaffolds,False,no_term_above_threshold +5627,42054,16.030912,0.99658203,Radical SAM,interpro,64016,Thioredoxin-like superfamily,0.91503906,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,0.0,15.0,0.0,1.0,Cytochrome c CXXCH motif,True,assigned_too_few_test_positives +5628,88161,38.845814,0.60302734,Transmembrane helix,keyword,88161,Transmembrane helix,0.60302734,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5821251694296736,0.3106883136943145,0.1847585290208241,0.19424460431654678,1.6815911846716254,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,Transmembrane and interfacial alpha-helices,True,assigned_and_evaluated +5629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helix-loop hairpin,False,no_term_above_threshold +5630,59229,32.66173,0.9848633,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9848633,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9475886497216924,0.7711392177358483,0.0101905183872397,0.7391304347826086,75.67222671433954,17.0,17.0,106.27629233511585,1.3819031749869367e-34,SAM-binding Motif I loop,True,assigned_and_evaluated +5631,38873,16.916292,0.7783203,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.65283203,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.897069271758437,0.41377639935016985,0.002215330084182543,0.4,186.77866666666668,7.0,7.0,171.32471264367817,5.187219663614024e-16,AAA+ P-loop NTPase core,True,assigned_and_evaluated +5632,37341,20.683102,0.9897461,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98291016,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9881913303437967,0.3535031170047964,0.011962782454585734,0.2222222222222222,29.550242039993538,4.0,18.0,32.314905149051484,1.1718559878916475e-05,Glycine coil-to-beta junctions,True,assigned_and_evaluated +5633,25169,17.586302,0.8598633,pilus,go_cc,25169,pilus,0.8598633,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7759325044404973,0.03253115367869466,0.002215330084182543,,14.684562770562772,0.0,18.0,0.0,1.0,Long amphipathic axial assembly helices,True,assigned_and_evaluated +5634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase receiver domain,False,no_term_above_threshold +5635,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chromodomain histone methyl-lysine reader,False,no_term_above_threshold +5636,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme catalytic cores,False,no_term_above_threshold +5637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acylphosphatase-like domain fold,False,no_term_above_threshold +5638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic helices,False,no_term_above_threshold +5639,88009,17.50598,0.6230469,Repeat,keyword,88009,Repeat,0.6230469,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6398972183701771,0.14784117569816518,0.07266282676118742,,2.0346191070168222,9.0,17.0,4.693540345506232,5.634238438966202e-05,Low-complexity IDR repeat detector,True,assigned_and_evaluated +5640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sandwich ligand-binding modules,False,no_term_above_threshold +5641,85664,24.434858,0.97998047,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.97998047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycosyltransferase C-terminal donor loop,True,assigned_too_few_test_positives +5642,45324,16.080086,0.7807617,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.7807617,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.4920071047957371,0.002215330084182543,0.002215330084182543,,1.0,1.0,13.0,42.075511644318986,0.039418476313278925,Mature folded secretory domains,True,assigned_and_evaluated +5643,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal or low-complexity leaders,False,no_term_above_threshold +5644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core intramembrane helical bundles,False,no_term_above_threshold +5645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH67/84 N-terminal β-strand motif,False,no_term_above_threshold +5646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Primase ssDNA-binding zinc knuckle,False,no_term_above_threshold +5647,88161,47.982338,0.6357422,Transmembrane helix,keyword,88161,Transmembrane helix,0.6357422,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6797029767490356,0.458891449716318,0.1847585290208241,0.43884892086330934,2.483736215850671,13.0,13.0,5.4274920345926265,5.833912717653736e-10,Amphipathic juxtamembrane segments,True,assigned_and_evaluated +5648,36104,23.600546,0.9448242,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9448242,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Extracytoplasmic S/T/P-rich low-complexity tails,True,assigned_too_few_test_positives +5649,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich catalytic grooves,False,no_term_above_threshold +5650,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted beta-strand repeat scaffolds,False,no_term_above_threshold +5651,39971,25.897827,0.89160156,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.87353516,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,15.0,17.0,584.5196078431372,1.741555167543374e-40,Metallophosphoesterase C-terminal helix-loop,True,assigned_too_few_test_positives +5652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-tail motif,False,no_term_above_threshold +5653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic-loop motifs,False,no_term_above_threshold +5654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane loops and tails,False,no_term_above_threshold +5655,27932,40.28972,0.921875,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.8886719,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.98742451628805,0.9534334602459447,0.01949490474080638,0.9545454545454546,48.9068027221613,16.0,16.0,103.50868055555556,2.0382447968559693e-32,Ribosomal C-terminal rRNA-binding tails,True,assigned_and_evaluated +5656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar catalytic microenvironments,False,no_term_above_threshold +5657,85364,30.268143,0.89453125,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.89453125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,18.0,301.1161616161616,2.0260096530472245e-44,Extracellular clamshell ligand-binding domains,True,assigned_too_few_test_positives +5658,50806,20.486843,0.99853516,"Homeobox, conserved site",interpro,87384,DNA-binding,0.6933594,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,HTH DNA-binding helix hotspots,True,assigned_too_few_test_positives +5659,88161,79.557175,0.8730469,Transmembrane helix,keyword,88159,Transmembrane,0.8676758,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.9318560369096027,0.7801633776074002,0.1847585290208241,0.935251798561151,4.222610895107679,18.0,19.0,5.141834559087751,2.044185969474243e-12,Alpha-helical transmembrane segments,True,assigned_and_evaluated +5660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended charged coiled-coil IDR scaffolds,False,no_term_above_threshold +5661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal loop-to-helix initiation,False,no_term_above_threshold +5662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD-binding oxidoreductase core,False,no_term_above_threshold +5663,87732,19.119665,0.75439453,Lipid transport,keyword,87732,Lipid transport,0.75439453,44,keywords,Lipid transport,keyword:keywords:Lipid transport,,,,,,,,4.0,17.0,58.69652965788826,1.1120519807148467e-06,Terminal membrane-interacting segments,True,assigned_too_few_test_positives +5664,88058,35.643982,0.7080078,Signal,keyword,88058,Signal,0.7080078,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.682772552342452,0.14968348655257008,0.09127159946832078,,1.6399787822774303,0.0,19.0,0.0,1.0,Hydrophobic transmembrane helix residues,True,assigned_and_evaluated +5665,72011,15.707898,0.93115234,"AMP-binding enzyme, C-terminal domain superfamily",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.8930664,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,7.0,0.0,1.0,P-loop ATPase coupling hinge,True,assigned_too_few_test_positives +5666,88152,16.047894,0.74072266,Transducer,keyword,88152,Transducer,0.74072266,76,keywords,Transducer,keyword:keywords:Transducer,,,,,,,,0.0,11.0,0.0,1.0,Cytosolic juxtamembrane coupling helices,True,assigned_too_few_test_positives +5667,43583,18.547247,0.99365234,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.99365234,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,13.0,14.0,387.14935064935065,3.181492804924155e-33,Protease catalytic histidine site,True,assigned_and_evaluated +5668,45551,23.302828,0.77734375,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.77734375,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,13.0,0.0,1.0,Cationic β-loop polyanion-binding patch,True,assigned_too_few_test_positives +5669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic secondary structure detector,False,no_term_above_threshold +5670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TNase-like nuclease catalytic core,False,no_term_above_threshold +5671,81330,23.113531,0.97509766,DnaJ domain,gene3d,64599,Chaperone J-domain superfamily,0.9746094,27,gene3d,1.10.287.110,gene3d:gene3d:1.10.287.110,,,,,,,,0.0,12.0,0.0,1.0,PDZ C-terminus and PBM recognizer,True,assigned_too_few_test_positives +5672,47128,15.580987,0.81640625,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47529,Immunoglobulin-like fold,0.74121094,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,0.0,18.0,0.0,1.0,β-barrel interstrand loops,True,assigned_too_few_test_positives +5673,81858,15.823591,0.9794922,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6767578,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Secondary transporter TM helices,True,assigned_too_few_test_positives +5674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-rich disordered stretch detector,False,no_term_above_threshold +5675,36091,23.21415,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,19.0,19.0,377.3481012658228,1.8275710853354973e-48,GNAT acetyl-CoA GxG loop,True,assigned_too_few_test_positives +5676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RBP regulatory low-complexity IDRs,False,no_term_above_threshold +5677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type II glycoenzyme lumenal stem,False,no_term_above_threshold +5678,80926,18.158503,0.71533203,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.69091797,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.7980940627999452,0.4292156575925742,0.0057598582188746125,0.38461538461538464,74.51844147588,12.0,12.0,95.39359999999999,4.669519813145496e-24,Acidic STP-rich C-terminal IDRs,True,assigned_and_evaluated +5679,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory anchoring regions,False,no_term_above_threshold +5680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal ACT allosteric signal,False,no_term_above_threshold +5681,49236,19.387827,0.9165039,C-type lectin fold,interpro,49236,C-type lectin fold,0.9165039,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9987566607460036,0.8526315789473684,0.002215330084182543,0.8,384.8778947368421,1.0,12.0,45.16742424242424,0.036824980241435906,N-terminal targeting leaders and pro-regions,True,assigned_and_evaluated +5682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain core and flanking disorder,False,no_term_above_threshold +5683,38890,19.537714,0.99902344,HNH nuclease,interpro,88263,Zinc-finger,0.66796875,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,10.0,19.0,682.162471395881,7.760151477335883e-27,Cys/His metal-binding micro-motifs,True,assigned_too_few_test_positives +5684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal disordered interaction tails,False,no_term_above_threshold +5685,87852,16.496117,0.80810547,Nucleosome core,keyword,24789,nucleosome,0.7861328,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,19.0,0.0,1.0,Polybasic low-complexity tails,True,assigned_too_few_test_positives +5686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid gating helical arch,False,no_term_above_threshold +5687,37282,16.354845,0.7441406,Leucine-rich repeat,interpro,37282,Leucine-rich repeat,0.7441406,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,2.0,11.0,40.59993190330269,0.0018762546330850552,Terminal IDRs and targeting peptides,True,assigned_too_few_test_positives +5688,36091,19.103876,0.9741211,GNAT domain,interpro,46081,EF-hand domain pair,0.9379883,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,Glycine-enriched hinge loops,True,assigned_too_few_test_positives +5689,85649,35.141914,0.9794922,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9765625,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8643104589155735,0.7417888308836277,0.0101905183872397,0.7391304347826086,72.79206049149337,15.0,15.0,110.61410018552876,7.1622047874657735e-31,Motif I-adjacent SAM helix,True,assigned_and_evaluated +5690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Middle cupredoxin beta-sandwich,False,no_term_above_threshold +5691,36115,23.358547,0.9975586,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9975586,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,15.0,19.0,292.355344883949,3.0744261705648683e-35,BTB/POZ/T1 domain detector,True,assigned_too_few_test_positives +5692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-alpha loops,False,no_term_above_threshold +5693,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-core binding segments,False,no_term_above_threshold +5694,38317,29.811289,0.93066406,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.93066406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7766666666666666,0.1015385125455383,0.0031014621178555605,,32.738917545039996,0.0,11.0,0.0,1.0,ABC LSGGQ C-terminal helix,True,assigned_and_evaluated +5695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding-site edge loops,False,no_term_above_threshold +5696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-transmembrane regions,False,no_term_above_threshold +5697,52941,22.064325,0.93115234,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.90625,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,16.0,17.0,245.0387875674287,1.4394641651334948e-37,MFS cytosolic TM6–TM7 loop,True,assigned_too_few_test_positives +5698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GIY-YIG nucleic-acid processing domains,False,no_term_above_threshold +5699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-wide nucleotide kinase activation,False,no_term_above_threshold +5700,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse chain-wide Clp protease activation,False,no_term_above_threshold +5701,87149,15.717804,0.6699219,Amphibian defense peptide,keyword,88038,Secreted,0.61621094,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6920704351727232,0.03285950199249167,0.012405848471422242,,2.6487105713233463,0.0,20.0,0.0,1.0,Low-complexity alpha-helices,True,assigned_and_evaluated +5702,36104,20.470337,0.84375,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.84375,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Membrane helices and interfaces,True,assigned_too_few_test_positives +5703,52940,16.736696,0.9995117,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.9848633,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,11.0,11.0,608.3775510204082,5.281686029740134e-31,A-domain upstream linker helix,True,assigned_too_few_test_positives +5704,85664,16.482824,0.96240234,Glycogen Phosphorylase B;,gene3d,59224,Alpha/Beta hydrolase fold,0.90771484,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Hydrophobic Rossmann beta-sheet scaffold,True,assigned_too_few_test_positives +5705,27733,18.564001,0.7524414,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.71435547,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.7519851309797206,0.2611831645700603,0.0101905183872397,0.2608695652173913,25.630017497157656,4.0,19.0,11.30791844476055,0.0006615331211708729,Metazoan TF low-complexity IDRs,True,assigned_and_evaluated +5706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-binding lid helix,False,no_term_above_threshold +5707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,INRE-like short charged blocks,False,no_term_above_threshold +5708,46932,17.681225,0.7392578,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.7392578,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.7397196261682242,0.21304866341751588,0.004430660168365086,0.1,48.08508333333334,10.0,16.0,67.62817604355716,7.735479358270774e-17,Charged low-complexity IDRs,True,assigned_and_evaluated +5709,81799,23.303646,0.84375,1.10.8.60,gene3d,81799,1.10.8.60,0.84375,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,6.0,9.0,385.8964401294498,4.48186289272665e-15,σ54 bEBP AAA+-HTH linker,True,assigned_too_few_test_positives +5710,82029,26.440039,1.0,MFS general substrate transporter like domains,gene3d,88162,Transport,0.61376953,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Secondary-active transporter TM helices,True,assigned_too_few_test_positives +5711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipoyl-binding domain C-terminus,False,no_term_above_threshold +5712,87326,31.542942,0.6660156,Coiled coil,keyword,87326,Coiled coil,0.6660156,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6741495294166424,0.27154999256951706,0.03943287549844927,0.25842696629213485,6.886385766622472,19.0,20.0,11.977151617678155,5.677614873654298e-20,Long coiled-coil scaffolds,True,assigned_and_evaluated +5713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Allosteric coupling segments,False,no_term_above_threshold +5714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic C-terminal catalytic activation,False,no_term_above_threshold +5715,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic membrane-interface helices,False,no_term_above_threshold +5716,88009,27.67441,0.6894531,Repeat,keyword,88009,Repeat,0.6894531,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7209193245778611,0.19891738071800527,0.07266282676118742,0.06097560975609756,2.7375398065886456,16.0,19.0,7.465748385834474,1.0353113695623046e-12,Tyrosine-centered IDR sticker repeats,True,assigned_and_evaluated +5717,85364,20.988356,0.78466797,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.78466797,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,9.0,18.0,150.5580808080808,4.810359417404777e-18,Extracellular pocket-lining segments,True,assigned_too_few_test_positives +5718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop-strand active-site rim,False,no_term_above_threshold +5719,47717,15.598346,0.8457031,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.8457031,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,2.0,11.0,49.725604670558795,0.0012648045502703224,Serine recombinase catalytic helix,True,assigned_too_few_test_positives +5720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar assembly helix–coil arms,False,no_term_above_threshold +5721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix aromatic/Gly-Pro signature,False,no_term_above_threshold +5722,45551,17.905571,0.85498047,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.85498047,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,19.0,0.0,1.0,Helix preceding catalytic loop,True,assigned_too_few_test_positives +5723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic cell-wall proteins,False,no_term_above_threshold +5724,59237,16.935043,0.9946289,Ubiquitin-like domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9633789,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,5.0,17.0,92.29256965944273,3.8219922041870065e-09,Structured domain-initiating elements,True,assigned_too_few_test_positives +5725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UBC/E2-like fold recognition,False,no_term_above_threshold +5726,46284,15.802105,0.89160156,FMN-binding split barrel,interpro,83302,Nucleic acid-binding proteins,0.78027344,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,19.0,0.0,1.0,Sensor β-strand ligand pockets,True,assigned_too_few_test_positives +5727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal C-terminal region signature,False,no_term_above_threshold +5728,38317,27.178799,0.9379883,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9379883,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.982095238095238,0.08651261373035568,0.0031014621178555605,,27.894138455630397,0.0,5.0,0.0,1.0,ABC NBD signature-adjacent helix,True,assigned_and_evaluated +5729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helices,False,no_term_above_threshold +5730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix signal,False,no_term_above_threshold +5731,58239,15.927452,0.7060547,P-loop containing nucleoside triphosphate hydrolase,interpro,88153,Transferase,0.65478516,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8401838069463239,0.05837299032201302,0.017722640673460344,,3.293695978919585,0.0,17.0,0.0,1.0,Gly-rich catalytic loop motifs,True,assigned_and_evaluated +5732,66234,17.80625,0.8232422,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.8232422,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,2.0,18.0,26.287918871252202,0.004512511557996442,C-terminal disordered low-complexity tails,True,assigned_too_few_test_positives +5733,45272,28.857378,0.9995117,"Lambda repressor-like, DNA-binding domain superfamily",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9995117,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,14.0,19.0,327.84524744697563,2.235764636472492e-33,HTH/homeodomain recognition helix,True,assigned_too_few_test_positives +5734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compositional bias at termini,False,no_term_above_threshold +5735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory PUA/THUMP RNA-binding modules,False,no_term_above_threshold +5736,81858,15.818991,0.90234375,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7167969,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane helices and tails,True,assigned_too_few_test_positives +5737,39958,17.415892,0.92578125,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.92578125,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9986672589960018,0.5021825396825397,0.002658396101019052,1.0,188.904332010582,0.0,19.0,0.0,1.0,Elongated coiled-coil scaffolds,True,assigned_and_evaluated +5738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged core-IDR activation regions,False,no_term_above_threshold +5739,25167,16.94018,0.73339844,cell outer membrane,go_cc,25167,cell outer membrane,0.73339844,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9964922048997773,0.7119596030886354,0.005316792202038104,0.8333333333333334,133.9077353475875,13.0,18.0,98.53457920162725,3.608055545265048e-24,Outer-membrane β-barrel junctions and β-signal,True,assigned_and_evaluated +5740,37020,17.208174,0.99072266,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.95214844,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,9.0,18.0,408.36301369863014,4.891298982886419e-22,Leloir-type glycosyltransferase active site,True,assigned_too_few_test_positives +5741,46081,16.002028,0.9160156,EF-hand domain pair,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8574219,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.933859493108048,0.027696764740384742,0.003544528134692069,,7.8139497523810455,0.0,11.0,0.0,1.0,Exposed aliphatic loop clusters,True,assigned_and_evaluated +5742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory disordered nucleic-acid regions,False,no_term_above_threshold +5743,64620,15.80849,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.921875,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,13.0,13.0,324.0271739130435,6.732438687398739e-33,Histidine-kinase ATP-lid hinge,True,assigned_too_few_test_positives +5744,59224,17.461021,0.91503906,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.82128906,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9307936507936508,0.0309888325049789,0.0031014621178555605,,9.991684994819625,1.0,18.0,7.631976446492574,0.19784356133171827,Polar xLxNx loop motif,True,assigned_and_evaluated +5745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide-stabilized extracellular microdomains,False,no_term_above_threshold +5746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro-rich disordered regulatory regions,False,no_term_above_threshold +5747,59224,18.002022,0.8857422,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8652344,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9471746031746031,0.030483351504357242,0.0031014621178555605,,9.828703477904899,0.0,17.0,0.0,1.0,Beta-sheet packing signal,True,assigned_and_evaluated +5748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-start entry segments,False,no_term_above_threshold +5749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-flanked Gly/Pro NIDO loops,False,no_term_above_threshold +5750,36535,20.334875,0.9277344,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.90527344,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9466399643969737,0.4716496372234078,0.004430660168365086,0.9,106.45132312132314,0.0,14.0,0.0,1.0,Cyclic-nucleotide acidic active-site motifs,True,assigned_and_evaluated +5751,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-binding interfaces and helix-end gating,False,no_term_above_threshold +5752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA modification and RNP assembly,False,no_term_above_threshold +5753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface exposed interaction patches,False,no_term_above_threshold +5754,47529,17.023571,0.6435547,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6435547,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7362784471218206,0.061012704035090286,0.007089056269384138,,8.606604562949924,0.0,19.0,0.0,1.0,ApaG/GAE β-strand signature,True,assigned_and_evaluated +5755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed ligand-binding regions,False,no_term_above_threshold +5756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved sulfotransferase catalytic helix,False,no_term_above_threshold +5757,39958,17.92155,0.98046875,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.98046875,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,1.0,0.9999999999999999,0.002658396101019052,1.0,376.16666666666663,15.0,17.0,417.51400560224084,2.952834779960458e-38,IDR-only activation in bZIPs,True,assigned_and_evaluated +5758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta metabolic enzyme cores,False,no_term_above_threshold +5759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic disordered tails and linkers,False,no_term_above_threshold +5760,85791,28.603056,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9995117,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,14.0,14.0,648.054347826087,1.2212665962156233e-39,MBL fold binuclear hydrolases,True,assigned_too_few_test_positives +5761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helical small protein activation,False,no_term_above_threshold +5762,72011,18.157597,0.97753906,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.9375,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,19.0,0.0,1.0,Charged disordered termini and linkers,True,assigned_too_few_test_positives +5763,25169,15.600754,0.8330078,pilus,go_cc,25169,pilus,0.8330078,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8821047957371226,0.06289503670410132,0.002215330084182543,,28.390819568231336,0.0,16.0,0.0,1.0,Extracellular Trp-Gly recognition loops,True,assigned_and_evaluated +5764,72011,16.130959,0.9057617,"AMP-binding enzyme, C-terminal domain superfamily",interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.86376953,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,MBL/MPP metallophosphoesterase catalytic cores,True,assigned_too_few_test_positives +5765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic helical surfaces,False,no_term_above_threshold +5766,87239,16.359608,0.7973633,CF(1),keyword,87239,CF(1),0.7973633,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9993294590970049,0.8471749503170287,0.008861320336730172,1.0,95.6036931432767,0.0,13.0,0.0,1.0,c-di-GMP PDE catalytic core,True,assigned_and_evaluated +5767,36535,21.01713,0.9370117,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9135742,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9857810413885181,0.16684700246985879,0.004430660168365086,,37.65736845744713,0.0,17.0,0.0,1.0,Histidine kinase HATPase_c N/G-box,True,assigned_and_evaluated +5768,36091,22.451569,1.0,GNAT domain,interpro,85712,3.40.630.30,0.9824219,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase ATP-lid glycine loop,True,assigned_too_few_test_positives +5769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved helical aromatic hotspots,False,no_term_above_threshold +5770,37640,19.759686,0.9868164,EF-hand domain,interpro,46081,EF-hand domain pair,0.97998047,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,16.0,18.0,266.3137911781128,1.2647350619045459e-37,EF-hand calcium-binding motifs,True,assigned_too_few_test_positives +5771,87413,18.964697,0.61328125,Disulfide bond,keyword,88058,Signal,0.609375,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6009134034591472,0.10347937638281042,0.0717766947275144,,1.4416848919506366,4.0,17.0,2.7828745463668505,0.0820134458139261,Exposed glycan-binding edge strands,True,assigned_and_evaluated +5772,37446,20.695616,0.9892578,F-box domain,interpro,63831,F-box-like domain superfamily,0.98828125,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9904126984126983,0.181861340413972,0.0031014621178555605,,58.637292187762114,0.0,14.0,0.0,1.0,Short conserved helix-end motifs,True,assigned_and_evaluated +5773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich linkers/hinges,False,no_term_above_threshold +5774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane segments,False,no_term_above_threshold +5775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C5 cytosine DNA methyltransferase core,False,no_term_above_threshold +5776,64475,22.554447,0.97509766,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.9453125,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9957150692444809,0.39006044899769593,0.0057598582188746125,1.0,67.72049487598458,0.0,10.0,0.0,1.0,ABC NBD hydrophobic helix motif,True,assigned_and_evaluated +5777,69819,19.233883,0.9267578,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.9111328,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,GxGAxG C-terminal phosphate-binding helix,True,assigned_too_few_test_positives +5778,82029,19.650808,0.95410156,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6645508,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix starts and cores,True,assigned_too_few_test_positives +5779,82029,24.701504,0.99902344,MFS general substrate transporter like domains,gene3d,25079,plasma membrane,0.62060547,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,17.0,188.0788643533123,1.0133225259294918e-38,MFS/SLC transmembrane hydrophobic residues,True,assigned_too_few_test_positives +5780,83302,16.828302,0.97998047,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.97753906,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9848012628511292,0.25651130507542963,0.004873726185201595,,52.6314559595677,13.0,18.0,148.48141762452107,1.7377161008037505e-26,Conserved N-terminal beta-strand cores,True,assigned_and_evaluated +5781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal aromatic NP motif,False,no_term_above_threshold +5782,87413,48.807297,0.87402344,Disulfide bond,keyword,87413,Disulfide bond,0.87402344,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9082500957600401,0.37676851686184587,0.0717766947275144,0.06172839506172839,5.249176188624606,9.0,20.0,5.322247569926602,2.882010742659044e-05,Secreted cysteine crosslink detector,True,assigned_and_evaluated +5783,36354,19.218897,0.9633789,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.95166016,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,18.0,0.0,1.0,Charge-rich oligomerization scaffolds,True,assigned_too_few_test_positives +5784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease-gated regulatory segments,False,no_term_above_threshold +5785,87149,20.520199,0.6713867,Amphibian defense peptide,keyword,87162,Antimicrobial,0.6357422,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.689226430814587,0.06966643341932645,0.012405848471422242,,5.6156121509792785,0.0,17.0,0.0,1.0,Low-complexity membrane-active effectors,True,assigned_and_evaluated +5786,47529,24.898294,0.93066406,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.93066406,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9906849620705042,0.41633467055357853,0.007089056269384138,0.125,58.72920946496417,12.0,18.0,51.55296152183312,8.732053544364814e-19,Aromatic β-sandwich β-strands,True,assigned_and_evaluated +5787,37020,17.297026,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9711914,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,13.0,17.0,624.5551974214343,5.471029150974689e-35,Glycosyltransferase C-terminal motif,True,assigned_too_few_test_positives +5788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic and disulfide residues,False,no_term_above_threshold +5789,64026,22.029352,0.9711914,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.828125,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.8623204501702948,0.036273804023969514,0.002658396101019052,,13.64499594701653,19.0,20.0,160.90894886363637,5.361326338743696e-41,Transporter TM boundary loops,True,assigned_and_evaluated +5790,82029,22.637543,0.99316406,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.63183594,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,11.0,16.0,129.3042192429022,9.372785190187698e-22,Transmembrane helix start detector,True,assigned_too_few_test_positives +5791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction modules,False,no_term_above_threshold +5792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain and tail activation,False,no_term_above_threshold +5793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta-strand core preference,False,no_term_above_threshold +5794,37894,25.734474,0.9165039,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.79003906,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,SDR substrate binding loop,True,assigned_too_few_test_positives +5795,37576,16.238085,0.9511719,"Zinc finger, PHD-type",interpro,37576,"Zinc finger, PHD-type",0.9511719,31,ip,IPR001965,interpro:ip:IPR001965,,,,,,,,0.0,19.0,0.0,1.0,M16 metallopeptidase internal helix,True,assigned_too_few_test_positives +5796,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UbiA-family transmembrane prenyltransferases,False,no_term_above_threshold +5797,29104,22.495325,0.81884766,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.8144531,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,8.0,11.0,311.9476782210595,2.971522223504735e-19,Transmembrane boundary and packing motifs,True,assigned_too_few_test_positives +5798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminal activation,False,no_term_above_threshold +5799,85682,15.698326,0.84472656,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7685547,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9642921146953405,0.1648947014128109,0.011076650420912717,,14.886693643548567,0.0,14.0,0.0,1.0,RluC/D RNA-binding motifs,True,assigned_and_evaluated +5800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage tail terminator/completion beta-strands,False,no_term_above_threshold +5801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RnfC/RsxC conserved motif,False,no_term_above_threshold +5802,38873,20.632235,0.9580078,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.90966797,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8917406749555951,0.27685332242709293,0.002215330084182543,0.4,124.97158974358976,14.0,19.0,126.23926194797338,1.5495660496598028e-27,ORC/Cdc6 post-P-loop helix,True,assigned_and_evaluated +5803,27733,21.33615,0.8383789,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.8383789,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8597076797322019,0.36806907850006076,0.0101905183872397,0.2608695652173913,36.11877870324509,6.0,18.0,17.904204204204202,1.2152809850356073e-06,TF/chromatin regulatory IDRs,True,assigned_and_evaluated +5804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand edge interaction patches,False,no_term_above_threshold +5805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NAD(P) TIM-barrel cofactor loops,False,no_term_above_threshold +5806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan/polyanion-binding beta surfaces,False,no_term_above_threshold +5807,59224,20.800514,0.9355469,Alpha/Beta hydrolase fold,interpro,87601,Hydrolase,0.64941406,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9825396825396825,0.09608303394810946,0.0031014621178555605,,30.979915374411867,0.0,18.0,0.0,1.0,EEP GDxN active-site Asn,True,assigned_and_evaluated +5808,59229,21.146524,0.67333984,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.67333984,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7103557666108753,0.1304532545096244,0.0101905183872397,,12.801434583835748,11.0,18.0,64.94662309368192,3.4600102553844445e-18,RNA m5C methyltransferase recognition motif,True,assigned_and_evaluated +5809,49116,23.27138,0.9711914,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9711914,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9984902309058615,0.4922222222222221,0.002215330084182543,0.6,222.1891111111111,17.0,20.0,73.98226277372262,3.6634970709041876e-30,HEAT/ARM alpha-solenoid scaffolds,True,assigned_and_evaluated +5810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asp-rich disordered tandem repeats,False,no_term_above_threshold +5811,85649,26.527649,0.7421875,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.74072266,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6181055622591568,0.1902052735811931,0.0101905183872397,0.17391304347826086,18.664926194467512,11.0,11.0,110.61410018552876,8.372133250060158e-23,Broad SAM-dependent methyltransferase signature,True,assigned_and_evaluated +5812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted glycine-rich beta repeats,False,no_term_above_threshold +5813,87384,15.783484,0.63720703,DNA-binding,keyword,87384,DNA-binding,0.63720703,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.5723710693590212,0.05630196221936311,0.043863535666814356,,1.283570997263662,1.0,19.0,0.6447395455970931,1.0,N-terminal linker/coiled-coil peaks,True,assigned_and_evaluated +5814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor TMs of glycosyltransferases,False,no_term_above_threshold +5815,52236,20.65216,0.99902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99365234,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR helix register marker,True,assigned_too_few_test_positives +5816,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helix capping/packing,False,no_term_above_threshold +5817,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal outer-membrane beta-barrel loops,False,no_term_above_threshold +5818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic helix propensity,False,no_term_above_threshold +5819,59229,40.064266,0.9707031,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9707031,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8677552450274414,0.7417888308836277,0.0101905183872397,0.7391304347826086,72.79206049149337,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM-binding Rossmann motif I,True,assigned_and_evaluated +5820,37020,17.58025,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9814453,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,19.0,773.7404470079307,1.0307916309183318e-50,Glycosyltransferase hydrophobic beta-strand scaffold,True,assigned_too_few_test_positives +5821,46277,16.930864,0.9111328,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9111328,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9601513802315227,0.09055812227496873,0.004873726185201595,,18.580880179509496,1.0,12.0,15.673238696109358,0.10147046251424106,MDR GDxV beta strand hotspot,True,assigned_and_evaluated +5822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase-like N-lobe beta-alpha scaffold,False,no_term_above_threshold +5823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble domain functional surfaces,False,no_term_above_threshold +5824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Gly-rich beta-strand caps,False,no_term_above_threshold +5825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices and junctions,False,no_term_above_threshold +5826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp nucleotide-binding loops,False,no_term_above_threshold +5827,85364,17.297709,0.7817383,Periplasmic binding protein-like II,gene3d,64148,Winged helix DNA-binding domain superfamily,0.703125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,18.0,217.47278338945006,1.1836377999383036e-28,Post-HTH loop-to-beta hinge,True,assigned_too_few_test_positives +5828,31094,16.24655,0.94433594,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.84033203,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9495327102803738,0.8443644224381929,0.004430660168365086,0.9,190.57305014430014,8.0,15.0,378.54603174603176,1.8015575005659658e-19,FabD-like AT/MAT core,True,assigned_and_evaluated +5829,25167,16.214878,0.73779297,cell outer membrane,go_cc,25167,cell outer membrane,0.73779297,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9521900519673347,0.4927500645738351,0.005316792202038104,0.75,92.67807464526214,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel strand detector,True,assigned_and_evaluated +5830,36914,16.176828,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.97509766,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Donor-binding lid helix,True,assigned_too_few_test_positives +5831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal alpha-glycan groove loops,False,no_term_above_threshold +5832,50338,19.030302,0.9472656,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6171875,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Aromatic TM entry helices,True,assigned_too_few_test_positives +5833,85364,23.598642,0.9794922,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9794922,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,17.0,301.1161616161616,4.0879330105973736e-42,Clamshell ligand-binding hinge loops,True,assigned_too_few_test_positives +5834,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted esterase His–Asp region,False,no_term_above_threshold +5835,36499,16.186255,0.70703125,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.70703125,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,13.0,0.0,1.0,Folded catalytic core activation,True,assigned_too_few_test_positives +5836,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-domain regulatory segments,False,no_term_above_threshold +5837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal luminal/periplasmic transferase regions,False,no_term_above_threshold +5838,59218,18.511543,0.7314453,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.7314453,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,14.0,17.0,458.87520615722923,5.593658472110794e-36,Acidic metal-binding active sites,True,assigned_too_few_test_positives +5839,82029,16.632109,0.8564453,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7348633,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,12.0,0.0,1.0,Multi-pass alpha-helical transmembrane segments,True,assigned_too_few_test_positives +5840,45324,16.628506,0.79345703,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.79345703,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.8932060390763766,0.10903127862981693,0.002215330084182543,,49.216719173499364,3.0,19.0,86.36552390149686,1.0585806119792982e-05,Periodic solenoid and coiled-coil registers,True,assigned_and_evaluated +5841,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ricin B-like β-trefoil lectins,False,no_term_above_threshold +5842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclin-box C-terminal peak,False,no_term_above_threshold +5843,49116,16.813536,0.77783203,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.77783203,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.7934280639431617,0.12618024968073183,0.002215330084182543,,56.95776470588235,2.0,17.0,10.23975955345642,0.027038046790697212,Extended α-helical scaffold cores,True,assigned_and_evaluated +5844,84152,24.34658,0.98535156,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.98535156,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,14.0,14.0,562.4622641509434,9.417075282476258e-39,N-terminal HxH metal-binding loop,True,assigned_too_few_test_positives +5845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic repeats and redox sites,False,no_term_above_threshold +5846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter pore-lining helices,False,no_term_above_threshold +5847,64596,30.246704,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,18.0,18.0,614.6494845360825,1.1510569634513847e-49,MBL catalytic core pocket,True,assigned_too_few_test_positives +5848,88009,18.769997,0.60058594,Repeat,keyword,88009,Repeat,0.60058594,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.709467097059886,0.22855590674402854,0.07266282676118742,0.31097560975609756,3.1454309848858073,12.0,13.0,8.183608807549328,1.0389468136838301e-10,First-repeat domain detector,True,assigned_and_evaluated +5849,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central alpha-helical scaffolds,False,no_term_above_threshold +5850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic amphipathic helical segments,False,no_term_above_threshold +5851,45324,17.140331,0.99658203,Pectin lyase fold/virulence factor,interpro,64507,Ankyrin repeat-containing domain superfamily,0.86083984,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9993783303730017,0.6683333333333333,0.002215330084182543,1.0,301.6856666666667,13.0,16.0,444.42259174311926,3.104562263473962e-33,Extracellular beta-solenoid repeats,True,assigned_and_evaluated +5852,85649,22.274847,0.93115234,Vaccinia Virus protein VP39,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.81884766,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9778424350940018,0.23583104039721228,0.0101905183872397,,23.142202529413396,0.0,16.0,0.0,1.0,Aliphatic helical packing motif,True,assigned_and_evaluated +5853,82029,17.270895,0.8496094,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6455078,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,ABC transporter extramembrane patches,True,assigned_too_few_test_positives +5854,82029,31.499685,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS gating helix pair,True,assigned_too_few_test_positives +5855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal amphipathic regulatory motifs,False,no_term_above_threshold +5856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface beta–alpha loop tips,False,no_term_above_threshold +5857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane anchor region,False,no_term_above_threshold +5858,37430,15.672132,1.0,"Signal transduction response regulator, receiver domain",interpro,64026,MFS transporter superfamily,0.83691406,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,19.0,19.0,484.7235772357723,2.572132453150849e-50,Two-component phosphotransfer interface,True,assigned_too_few_test_positives +5859,55053,18.743397,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,14.0,14.0,552.0462962962963,1.2209404069247088e-38,Histidine-centered acyltransferase motifs,True,assigned_too_few_test_positives +5860,69819,17.939896,0.83935547,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.7973633,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,Mobile ATP-lid/hinge subdomain,True,assigned_too_few_test_positives +5861,36668,15.808279,0.91748047,AMP-dependent synthetase/ligase domain,interpro,36354,RNA recognition motif domain,0.7685547,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,16.0,0.0,1.0,PAS-family sensory interfaces,True,assigned_too_few_test_positives +5862,35372,15.617402,0.97558594,ABC-type transporter activity,go_mf,81858,Rhodopsin 7-helix transmembrane proteins,0.81689453,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,15.0,16.0,657.5845588235294,9.455180686344042e-42,C-terminal transporter TM helices,True,assigned_too_few_test_positives +5863,37894,20.181461,1.0,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.95410156,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR Rossmann hydrophobic β-strands,True,assigned_too_few_test_positives +5864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coil-to-structure initiators,False,no_term_above_threshold +5865,46081,15.640782,0.9086914,EF-hand domain pair,interpro,46081,EF-hand domain pair,0.9086914,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.9376667407736772,0.030414796734419637,0.003544528134692069,,8.580774528698141,1.0,18.0,14.215784453981879,0.11124139060973419,Short solvent-exposed patches,True,assigned_and_evaluated +5866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-centered Zn/thiol active sites,False,no_term_above_threshold +5867,36914,17.576437,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,9.0,11.0,602.2323232323233,1.6238081620845994e-24,Glycosyltransferase DXD metal-binding loop,True,assigned_too_few_test_positives +5868,52941,19.216866,0.9633789,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.70410156,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,18.0,0.0,1.0,Alpha-helical transmembrane segments,True,assigned_too_few_test_positives +5869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-core activation,False,no_term_above_threshold +5870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical flanks of metallophosphohydrolases,False,no_term_above_threshold +5871,39971,18.483665,0.97265625,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,85682,NAD(P)-binding Rossmann-like Domain,0.88916016,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,11.0,0.0,1.0,SDR catalytic β–α turn,True,assigned_too_few_test_positives +5872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible interdomain linker/hinge regions,False,no_term_above_threshold +5873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CRISPR effector core activation,False,no_term_above_threshold +5874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-adjacent catalytic loop,False,no_term_above_threshold +5875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane coupling helices,False,no_term_above_threshold +5876,25167,16.311218,0.71972656,cell outer membrane,go_cc,25167,cell outer membrane,0.71972656,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9553823311061618,0.613008833582604,0.005316792202038104,0.8333333333333334,115.29674478299478,19.0,20.0,129.61086956521737,2.8346608292965217e-39,Outer-membrane beta-barrel detector,True,assigned_and_evaluated +5877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-metal nuclease/polymerase cores,False,no_term_above_threshold +5878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble coil to beta transitions,False,no_term_above_threshold +5879,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular polar low-complexity repeats,False,no_term_above_threshold +5880,85762,30.995,0.8857422,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.8823242,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,9.0,9.0,205.58965517241379,3.6095791259208094e-21,Mid-domain FAD-binding α/β core,True,assigned_too_few_test_positives +5881,50869,16.389719,1.0,"DNA binding HTH domain, AraC-type",interpro,64507,Ankyrin repeat-containing domain superfamily,0.9941406,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,18.0,0.0,1.0,Ankyrin repeat start motif,True,assigned_too_few_test_positives +5882,50806,23.345203,0.90771484,"Homeobox, conserved site",interpro,80926,Homeodomain-like,0.7392578,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,11.0,0.0,1.0,Pre-HTH amphipathic helix,True,assigned_too_few_test_positives +5883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mycobacterial N-terminal helical domains,False,no_term_above_threshold +5884,36104,19.570524,0.9711914,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.96875,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Polymerase palm pre-motif C helix,True,assigned_too_few_test_positives +5885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cupredoxin copper-binding loops,False,no_term_above_threshold +5886,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Integral membrane helices and loops,False,no_term_above_threshold +5887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-capping hinge segments,False,no_term_above_threshold +5888,25169,20.181253,0.86572266,pilus,go_cc,25169,pilus,0.86572266,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9925399644760213,0.1658859497989933,0.002215330084182543,,74.88091773926558,2.0,17.0,64.94662309368191,0.0007731745487748749,Beta-rich adhesin domains,True,assigned_and_evaluated +5889,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil heptad face,False,no_term_above_threshold +5890,36104,18.91152,0.9736328,Rho GTPase-activating protein domain,interpro,45290,Protein kinase-like domain superfamily,0.96728516,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Conserved kinase αE helix,True,assigned_too_few_test_positives +5891,36354,17.473501,0.97265625,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.96972656,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,16.0,0.0,1.0,Helix turn beta junctions,True,assigned_too_few_test_positives +5892,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal-to-core helix activation,False,no_term_above_threshold +5893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic interaction helix-coil segments,False,no_term_above_threshold +5894,27013,20.299168,0.84472656,side of membrane,go_cc,88161,Transmembrane helix,0.6035156,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.8123796831038056,0.036963903306116416,0.002658396101019052,,13.904588293650791,0.0,19.0,0.0,1.0,N-terminal signal-anchor helix,True,assigned_and_evaluated +5895,46929,15.56452,0.87109375,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.81103516,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9459591474245115,0.04917309510887767,0.002215330084182543,,22.19673513214738,5.0,18.0,23.86367275056036,3.043996275979316e-06,PDZ and chromatin readers,True,assigned_and_evaluated +5896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site scaffold helices,False,no_term_above_threshold +5897,38317,17.900528,0.7314453,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7314453,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.706095238095238,0.10483348855714195,0.0031014621178555605,,33.801311953352766,0.0,18.0,0.0,1.0,CAZyme glycan-binding cleft,True,assigned_and_evaluated +5898,36104,17.845438,0.97802734,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.97802734,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Deubiquitinase catalytic core scaffolds,True,assigned_too_few_test_positives +5899,85791,16.18847,0.76708984,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,59218,Metallo-dependent phosphatase-like,0.7548828,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,2.0,14.0,92.57919254658385,0.0003820709004192701,Noncatalytic peripheral nuclease tails,True,assigned_too_few_test_positives +5900,63831,17.200745,0.87841797,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.87841797,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8661335702650673,0.011035160785662829,0.002658396101019052,,4.151059648873501,0.0,15.0,0.0,1.0,Motif-adjacent linker/loop hotspots,True,assigned_and_evaluated +5901,37894,22.970518,0.9760742,Short-chain dehydrogenase/reductase SDR,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9536133,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,19.0,0.0,1.0,GHKL ATPase G1 loop,True,assigned_too_few_test_positives +5902,85672,20.194319,0.6279297,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.62402344,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5890364700585322,0.05717240814998771,0.01595037660611431,0.027777777777777776,3.5843923665145074,17.0,17.0,40.01409395973155,1.7557395315514075e-27,ATPase mechanochemical coupling hinges,True,assigned_and_evaluated +5903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent outer-membrane β-barrel scaffold,False,no_term_above_threshold +5904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amylin motif hotspot,False,no_term_above_threshold +5905,87326,34.35432,0.70751953,Coiled coil,keyword,87326,Coiled coil,0.70751953,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.74870952361209,0.28151364170220905,0.03943287549844927,0.1797752808988764,7.1390594305829875,12.0,17.0,8.899431542547237,5.40344968161759e-10,Coiled-coil register recognition,True,assigned_and_evaluated +5906,88252,16.079369,0.91308594,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.90234375,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.9942318784849067,0.5398353632201897,0.012405848471422242,0.9285714285714286,43.51458624242743,1.0,18.0,7.1539476841852645,0.2095932343508294,Catalysis adjacent interstrand loops,True,assigned_and_evaluated +5907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-chain active-site lid segment,False,no_term_above_threshold +5908,82029,18.192547,0.7236328,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.7167969,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,Interhelical TM loop hinges,True,assigned_too_few_test_positives +5909,88160,19.003729,0.8051758,Transmembrane beta strand,keyword,25167,cell outer membrane,0.69140625,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,17.0,221.32295830953737,5.721118510676694e-29,Outer membrane β-barrel pores,True,assigned_too_few_test_positives +5910,39971,20.590961,0.82714844,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.82177734,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,Hydrolase active-site loop,True,assigned_too_few_test_positives +5911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed helical surface patch,False,no_term_above_threshold +5912,36914,19.632101,0.9765625,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.88378906,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,4.0,10.0,294.4246913580247,1.3649736869534026e-09,Low complexity glycosyltransferase tails,True,assigned_too_few_test_positives +5913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic region activation,False,no_term_above_threshold +5914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyl cyclase catalytic core,False,no_term_above_threshold +5915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal cytoplasmic tails,False,no_term_above_threshold +5916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme active site neighborhoods,False,no_term_above_threshold +5917,63960,25.282145,0.9267578,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9267578,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,19.0,19.0,193.57467532467533,3.1320939821269373e-43,Rossmann FAD-binding beta-alpha linker,True,assigned_too_few_test_positives +5918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short junctional linear motifs,False,no_term_above_threshold +5919,87108,19.025547,0.9243164,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.91796875,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9152332937920127,0.02401723518457923,0.003987594151528578,,6.0229888679550365,0.0,15.0,0.0,1.0,Internal helices and caps,True,assigned_and_evaluated +5920,69819,24.540232,0.91308594,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.88623047,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,ASKHA β–α catalytic/interface motif,True,assigned_too_few_test_positives +5921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site proximal binding loops,False,no_term_above_threshold +5922,85649,18.0976,0.6542969,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.65185547,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7124187458643104,0.2868035800554353,0.0101905183872397,0.391304347826087,28.144160008048587,0.0,16.0,0.0,1.0,Catalytic domain N-terminal cap,True,assigned_and_evaluated +5923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic multi-pass membrane proteins,False,no_term_above_threshold +5924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic loop-capping motif,False,no_term_above_threshold +5925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-onset leaders,False,no_term_above_threshold +5926,37446,18.856062,0.95458984,F-box domain,interpro,37446,F-box domain,0.95458984,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9301269841269841,0.0283621712776491,0.0031014621178555605,,9.14477436766486,0.0,14.0,0.0,1.0,Cationic amphipathic helix patches,True,assigned_and_evaluated +5927,81799,20.541628,0.97558594,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7739258,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,4.0,15.0,154.35857605177992,2.267252470209769e-08,AAA+ ATPase core activation,True,assigned_too_few_test_positives +5928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calycin-like beta-sheet patches,False,no_term_above_threshold +5929,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain onset detector,False,no_term_above_threshold +5930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helical bundles,False,no_term_above_threshold +5931,4066,22.182375,0.9277344,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9277344,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7906749555950267,0.1556553628029038,0.002215330084182543,0.2,70.26283076923077,12.0,19.0,453.6791376030437,4.384743648879992e-30,Acidic catalytic core activation,True,assigned_and_evaluated +5932,59224,25.158304,0.9838867,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9838867,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,20.0,20.0,137.37557603686636,1.3818410501239142e-42,Alpha/beta-hydrolase cap loop,True,assigned_and_evaluated +5933,64475,19.557186,0.9785156,ACP-like superfamily,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9433594,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9874537227478404,0.18919530805958257,0.0057598582188746125,,32.84721617619061,0.0,18.0,0.0,1.0,HTH recognition helix aromatic patch,True,assigned_and_evaluated +5934,29104,20.45733,0.70751953,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.70751953,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,9.0,0.0,1.0,Lipid/isoprenoid enzyme membrane hairpins,True,assigned_too_few_test_positives +5935,82029,16.122494,0.8613281,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.72998047,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,15.0,0.0,1.0,Hydrophobic membrane helical segments,True,assigned_too_few_test_positives +5936,85672,31.972471,0.9321289,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.92871094,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9661063584971734,0.5241151868763639,0.01595037660611431,0.3888888888888889,32.85911046610982,12.0,17.0,28.245242795104623,7.454747953527918e-16,Helices flanking NTP sites,True,assigned_and_evaluated +5937,38317,25.246773,0.953125,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.953125,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9559365079365079,0.03674394650096442,0.0031014621178555605,,11.847298178953814,0.0,7.0,0.0,1.0,Adenine-binding A-loop helix,True,assigned_and_evaluated +5938,88263,38.285934,0.91503906,Zinc-finger,keyword,88261,Zinc,0.8354492,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9352449858295182,0.17066840749246326,0.014621178555604785,,11.672684718499685,8.0,18.0,11.58139083139083,2.825104347083954e-07,Domain-boundary tethering segments,True,assigned_and_evaluated +5939,88009,28.697605,0.6850586,Repeat,keyword,88009,Repeat,0.6850586,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6871875473413118,0.20238257306777124,0.07266282676118742,0.07317073170731707,2.7852284598412176,13.0,19.0,6.0659205634905105,1.3383018452285157e-08,Low-complexity tandem repeats,True,assigned_and_evaluated +5940,45290,24.964508,0.95947266,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.95947266,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9862539421362951,0.23561767426720526,0.0057598582188746125,,40.90685314008325,1.0,16.0,4.5890548029556655,0.31136742210639545,ExK active-site beta-strand,True,assigned_and_evaluated +5941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar/acidic junction motifs,False,no_term_above_threshold +5942,49061,23.247887,0.9658203,WD40/YVTN repeat-like-containing domain superfamily,interpro,87697,Knottin,0.9169922,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9446260334551049,0.12991669083744264,0.012405848471422242,,10.472213257861002,6.0,19.0,31.223356899711963,5.040326812971901e-08,Beta-propeller boundary loops,True,assigned_and_evaluated +5943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-prone disordered tails,False,no_term_above_threshold +5944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal non-globular detector,False,no_term_above_threshold +5945,87326,30.463554,0.7270508,Coiled coil,keyword,87326,Coiled coil,0.7270508,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7851849164559062,0.3286115477261585,0.03943287549844927,0.3146067415730337,8.333441159752132,18.0,20.0,11.346775216747726,6.031390779229954e-18,Extended coiled-coil scaffolds,True,assigned_and_evaluated +5946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming N-terminal domains,False,no_term_above_threshold +5947,85364,26.010942,0.9868164,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9868164,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,N-terminal clamshell helix,True,assigned_too_few_test_positives +5948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavin decarboxylase pocket-edge motif,False,no_term_above_threshold +5949,52270,16.914715,0.9741211,"WD40 repeat, conserved site",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9526367,43,ip,IPR019775,interpro:ip:IPR019775,,,,,,,,0.0,18.0,0.0,1.0,Beta-propeller Ser/Thr motifs,True,assigned_too_few_test_positives +5950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta/alpha cap motif,False,no_term_above_threshold +5951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C metal-site flap,False,no_term_above_threshold +5952,37020,17.302921,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,17.0,768.6833199033038,1.7917833648140597e-45,Donor phosphate-binding helix–loop–β,True,assigned_too_few_test_positives +5953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible glycine-rich hinge loops,False,no_term_above_threshold +5954,36668,22.703707,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9736328,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,18.0,18.0,532.3303571428571,1.2239400872533205e-48,ANL AMP-binding N-subdomain,True,assigned_too_few_test_positives +5955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VAO/PCMH C-terminal substrate cap,False,no_term_above_threshold +5956,31094,16.236507,0.9848633,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.78515625,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9983088562527815,0.6004563492063492,0.004430660168365086,1.0,135.52299801587301,0.0,13.0,0.0,1.0,SDR post-YXXXK helix,True,assigned_and_evaluated +5957,64148,26.116035,0.97021484,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9160156,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8817788438925733,0.6288179168755689,0.008418254319893664,0.631578947368421,74.69694938885047,17.0,19.0,79.61956009426551,4.026449964464396e-31,HTH recognition helix C-cap,True,assigned_and_evaluated +5958,88160,19.841694,0.8886719,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7421875,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,14.0,17.0,238.34780125642487,6.326217497723888e-32,Outer membrane β-barrel loops,True,assigned_too_few_test_positives +5959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hinge/lid helices and linkers,False,no_term_above_threshold +5960,64058,21.760443,0.6586914,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.6586914,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8207439016623145,0.5894035387009626,0.006202924235711121,0.6428571428571429,95.02027048914805,16.0,16.0,113.99808795411089,4.441314123773332e-33,Mid-domain Rossmann NAD(P) core,True,assigned_and_evaluated +5961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich coiled-coil/IDR segments,False,no_term_above_threshold +5962,85364,20.392635,0.8408203,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8408203,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,C-terminal capping helix-loop,True,assigned_too_few_test_positives +5963,87198,16.29321,0.7114258,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.7114258,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,15.0,16.0,681.6425304878048,5.4172720716718785e-42,Flagellar and T3SS helical cores,True,assigned_too_few_test_positives +5964,84152,18.765186,0.94677734,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.94677734,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,17.0,0.0,1.0,Metallo-phosphoesterase active-site entry motif,True,assigned_too_few_test_positives +5965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane N-cap anchor motif,False,no_term_above_threshold +5966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader/anchor segments,False,no_term_above_threshold +5967,82029,17.305502,0.9272461,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6303711,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,13.0,0.0,1.0,TM helix micro-motif,True,assigned_too_few_test_positives +5968,85672,17.895037,0.7578125,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7480469,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8875819200560309,0.09024148319307464,0.01595037660611431,,5.657639654632485,1.0,16.0,2.5008808724832217,0.520672805911569,β-sheet nucleotide-binding interfaces,True,assigned_and_evaluated +5969,87489,16.29102,0.7548828,GPI-anchor,keyword,87489,GPI-anchor,0.7548828,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.6907301587301587,0.03662074891583088,0.0031014621178555605,,11.807575757575755,5.0,19.0,38.74009096816114,2.974307260662375e-07,Extracellular mucin-like PTS domains,True,assigned_and_evaluated +5970,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TM helix activation,False,no_term_above_threshold +5971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Citrate synthase helical activation,False,no_term_above_threshold +5972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible acidic glycine-rich loops,False,no_term_above_threshold +5973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal S4 RNA-binding domain,False,no_term_above_threshold +5974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil scaffolds,False,no_term_above_threshold +5975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered terminal tails,False,no_term_above_threshold +5976,87409,17.736187,0.8154297,Dioxygenase,keyword,48241,RmlC-like jelly roll fold,0.7680664,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,11.0,13.0,236.8475984109787,2.2147867107577503e-25,Cupin 2OG oxygenase active site,True,assigned_too_few_test_positives +5977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ion/cofactor-binding catalytic cores,False,no_term_above_threshold +5978,85649,23.211264,0.6875,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.6875,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6969366704293332,0.04059929429972946,0.0101905183872397,,3.984026401499538,10.0,11.0,100.55827289593522,9.444723526529006e-20,HemK/PrmC N-terminal accessory lobe,True,assigned_and_evaluated +5979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-LTR retrotransposon endonuclease region,False,no_term_above_threshold +5980,45290,33.539124,0.9716797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9716797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9608185931715344,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,14.0,15.0,68.52988505747128,3.0474954144632634e-25,Kinase N-lobe ATP-binding module,True,assigned_and_evaluated +5981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane β-barrel surface loops,False,no_term_above_threshold +5982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible C-terminal regulatory tails,False,no_term_above_threshold +5983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface helices,False,no_term_above_threshold +5984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved His-Gly loop motifs,False,no_term_above_threshold +5985,27932,33.195335,0.94384766,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.9042969,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9799480343425215,0.7245101570555339,0.01949490474080638,0.5909090909090909,37.16407782896228,13.0,13.0,103.50868055555556,1.777970126342942e-26,Cationic disordered RNA-binding segments,True,assigned_and_evaluated +5986,52236,20.13489,0.9038086,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7163086,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,4.0,20.0,44.65992509363296,3.4375466666726024e-06,GDG-centered PKD beta-strand motif,True,assigned_too_few_test_positives +5987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Membrane catalytic interfaces, hallmark residues",False,no_term_above_threshold +5988,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FG-rich disordered interaction hubs,False,no_term_above_threshold +5989,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular substrate-gating loops,False,no_term_above_threshold +5990,36876,17.170727,1.0,Cytochrome P450,interpro,64154,Cytochrome P450 superfamily,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,16.0,16.0,389.6797385620915,1.6482263221307779e-41,P450 C-terminal catalytic core,True,assigned_and_evaluated +5991,27735,16.660501,0.7709961,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.7709961,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.679679688308106,0.022446942145511357,0.011519716437749225,,1.9485672470161204,3.0,15.0,9.047192716236722,0.006929034121566928,Helix termini and loop junctions,True,assigned_and_evaluated +5992,36104,16.054382,0.91503906,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.91503906,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Amphipathic helix-turn hairpins,True,assigned_too_few_test_positives +5993,38317,21.923668,0.78808594,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.78808594,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6385396825396825,0.05436952509552041,0.0031014621178555605,,17.53028830579851,0.0,16.0,0.0,1.0,Charged N-terminal pre-domain arm,True,assigned_and_evaluated +5994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic juxtamembrane regulatory linker,False,no_term_above_threshold +5995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-level surface-exposed segments,False,no_term_above_threshold +5996,50806,19.96676,0.98828125,"Homeobox, conserved site",interpro,87384,DNA-binding,0.69433594,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,13.0,0.0,1.0,Post-HTH basic amphipathic helix,True,assigned_too_few_test_positives +5997,64003,29.095013,0.8676758,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.82177734,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.8854784499802294,0.46346244460998565,0.003987594151528578,0.3333333333333333,116.22608194274864,7.0,7.0,130.4617067833698,3.4813137924789586e-15,Tandem C2H2 zinc-finger arrays,True,assigned_and_evaluated +5998,88164,22.711897,0.8808594,Transposition,keyword,88164,Transposition,0.8808594,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.896891651865009,0.5437763993501699,0.002215330084182543,0.8,245.4606666666667,2.0,17.0,85.53945480631276,0.00045102154292737706,Hydrophobic DNA-interface scaffold,True,assigned_and_evaluated +5999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface helices,False,no_term_above_threshold +6000,29104,20.093534,0.7763672,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.7680664,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,11.0,11.0,428.9280575539568,2.68532943002915e-29,Internal multipass transmembrane helices,True,assigned_too_few_test_positives +6001,45551,15.944899,0.6870117,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.6870117,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,16.0,0.0,1.0,Polyisoprenyl-PP binding TM helix,True,assigned_too_few_test_positives +6002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease subdomain hydrophobic helix,False,no_term_above_threshold +6003,52236,20.179493,0.99658203,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99121094,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,18.0,210.8940907199334,9.175234661021449e-39,Helical repeat core hydrophobic register,True,assigned_too_few_test_positives +6004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Heme-proximal and jellyroll β-strands,False,no_term_above_threshold +6005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DEAD-box helicase RecA2-tail activation,False,no_term_above_threshold +6006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue hinge/turn detector,False,no_term_above_threshold +6007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,All-alpha helical scaffolds,False,no_term_above_threshold +6008,72011,16.24713,0.94433594,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.8955078,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,ATP-binding loop–beta motifs,True,assigned_too_few_test_positives +6009,35372,21.697792,0.9165039,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9165039,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,19.0,0.0,1.0,Secretory signal peptides and anchors,True,assigned_too_few_test_positives +6010,88160,16.513317,0.8720703,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7685547,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,20.0,231.5378640776699,6.036645647116142e-36,Outer-membrane beta-barrel loop signature,True,assigned_too_few_test_positives +6011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-linked glycan TM signature,False,no_term_above_threshold +6012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-GTPase stalk/membrane helices,False,no_term_above_threshold +6013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positive-inside TM helix starts,False,no_term_above_threshold +6014,59224,17.615877,0.92578125,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.92578125,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9886666666666666,0.38536336310422686,0.0031014621178555605,0.2857142857142857,124.25215864660572,5.0,12.0,57.239823348694316,3.035104048239182e-08,Crotonase dual-helix motif,True,assigned_and_evaluated +6015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PNPase catalytic core motif,False,no_term_above_threshold +6016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-biased internal methionine detector,False,no_term_above_threshold +6017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered linkers,False,no_term_above_threshold +6018,36010,20.71263,0.99902344,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.92089844,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,16.0,18.0,452.9610636277303,2.595630625196843e-41,AB hydrolase N-terminal oxyanion cap,True,assigned_too_few_test_positives +6019,38317,20.938913,0.9921875,Pentatricopeptide repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9472656,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9996825396825398,0.9087301587301586,0.0031014621178555605,1.0,293.000566893424,16.0,19.0,323.9171477079796,1.3500943960228663e-38,RNA helical repeat interfaces,True,assigned_and_evaluated +6020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-associated alpha-helical segments,False,no_term_above_threshold +6021,43583,15.977953,0.9375,"Peptidase S1, PA clan",interpro,88049,Serine protease,0.72753906,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,0.9983000080951996,0.8221042685365547,0.004873726185201595,0.7272727272727273,168.680848553364,9.0,10.0,375.23706293706294,5.739660023644406e-23,N-terminal targeting signals,True,assigned_and_evaluated +6022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic N-terminal heme/Zn domains,False,no_term_above_threshold +6023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site cap/lid segments,False,no_term_above_threshold +6024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short low-complexity disordered segments,False,no_term_above_threshold +6025,36776,18.37007,0.9970703,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.9296875,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9931141714793424,0.18923577884104198,0.002658396101019052,,71.18419214070529,8.0,19.0,134.24373768646214,1.3967156161068365e-15,HTH/SANT basic N-cap loop,True,assigned_and_evaluated +6026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH Asn-loop cofactor-channel motif,False,no_term_above_threshold +6027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isochorismatase N-terminal catalytic helix,False,no_term_above_threshold +6028,63951,18.389076,0.93408203,Immunoglobulin-like domain superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.93408203,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9886318703044682,0.33886243386243386,0.003987594151528578,0.5555555555555556,84.97916813639036,0.0,17.0,0.0,1.0,PAS and related sensory domains,True,assigned_and_evaluated +6029,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helical nucleic acid readers,False,no_term_above_threshold +6030,59224,19.374914,0.9536133,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.85791016,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9695873015873016,0.10066236909959947,0.0031014621178555605,,32.45642386539943,1.0,15.0,9.158371735791091,0.16775931673620395,Acidic beta-strand junction loops,True,assigned_and_evaluated +6031,87697,29.767363,0.9213867,Knottin,keyword,87697,Knottin,0.9213867,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9982139141291531,0.8698491145155579,0.017279574656623838,1.0,50.339729524656775,2.0,14.0,36.09019370460049,0.0024040209279298664,Cysteine-driven functional core segments,True,assigned_and_evaluated +6032,37894,17.052576,0.9609375,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8544922,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,9.0,709.7738095238095,4.424699527134814e-26,Conserved SDR mid-domain helix,True,assigned_too_few_test_positives +6033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved internal structural element,False,no_term_above_threshold +6034,64026,16.296156,0.7319336,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.6582031,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.6366799940767066,0.27955004184512383,0.002658396101019052,0.3333333333333333,105.1574074074074,5.0,20.0,42.34446022727273,1.9760183601738693e-07,Juxtamembrane loop/tail activation,True,assigned_and_evaluated +6035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inner membrane transport proteins,False,no_term_above_threshold +6036,87317,18.674942,0.83984375,Cleavage on pair of basic residues,keyword,88058,Signal,0.828125,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9140171798304328,0.3344484407432756,0.007089056269384138,0.1875,47.17813317234832,12.0,18.0,56.29933899905571,3.067535994346143e-19,Signal peptide hydrophobic h-region,True,assigned_and_evaluated +6037,83302,22.585258,0.94970703,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9404297,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9811988990528616,0.14826517667486488,0.004873726185201595,,30.42131852319728,0.0,17.0,0.0,1.0,Small beta-barrel recognition patch,True,assigned_and_evaluated +6038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sheet globular domain cores,False,no_term_above_threshold +6039,87525,15.62682,0.84521484,Glycosyltransferase,keyword,88153,Transferase,0.66503906,112,keywords,Glycosyltransferase,keyword:keywords:Glycosyltransferase,7.0,2257.0,0.7881904761904762,0.0198476953300334,0.0031014621178555605,,6.399464051412197,17.0,17.0,94.486529318542,1.0082446262746789e-33,Sugar nucleotide glycosyltransferase helices,True,assigned_and_evaluated +6040,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral RdRp flanking activation,False,no_term_above_threshold +6041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclophilin PPIase C-terminal motif,False,no_term_above_threshold +6042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic-TM envelope biogenesis modules,False,no_term_above_threshold +6043,85664,20.864687,0.9794922,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9794922,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Nucleotide-sugar envelope glycosyltransferases,True,assigned_too_few_test_positives +6044,63960,17.360628,0.93847656,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.93847656,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,18.0,0.0,1.0,Acidic Gly-Thr/Ser loop motif,True,assigned_too_few_test_positives +6045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTP-dependent nucleotidyltransfer catalytic core,False,no_term_above_threshold +6046,38317,19.09986,0.89208984,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.79248047,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7695873015873016,0.14932617461891465,0.0031014621178555605,,48.14702515927005,0.0,15.0,0.0,1.0,N-terminal helical scaffold,True,assigned_and_evaluated +6047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane lipid-contacting beta surfaces,False,no_term_above_threshold +6048,45289,15.566742,0.9345703,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.9345703,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,0.0,19.0,0.0,1.0,Short amphipathic edge interface,True,assigned_too_few_test_positives +6049,63960,37.957836,0.91503906,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.91503906,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,FAD/NAD(P)H Rossmann oxidoreductase domain,True,assigned_too_few_test_positives +6050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-lining helical hotspot,False,no_term_above_threshold +6051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-zipper membrane helices,False,no_term_above_threshold +6052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intein/HhC self-processing domains,False,no_term_above_threshold +6053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ASC domain and low-complexity IDRs,False,no_term_above_threshold +6054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended macromolecule binding interfaces,False,no_term_above_threshold +6055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-SET C-terminal helix motif,False,no_term_above_threshold +6056,85656,16.161446,0.81640625,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.81640625,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8713968253968255,0.02327878348826444,0.0031014621178555605,,7.50574490471612,0.0,18.0,0.0,1.0,Trp-acidic nucleotide-binding motif,True,assigned_and_evaluated +6057,38317,23.807497,0.94921875,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.94921875,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9891746031746032,0.2184284955507318,0.0031014621178555605,,70.42758777971453,0.0,12.0,0.0,1.0,LRR flanking cap motifs,True,assigned_and_evaluated +6058,46274,15.754411,0.8408203,Ribonuclease H-like superfamily,interpro,46274,Ribonuclease H-like superfamily,0.8408203,72,ip,IPR012337,interpro:ip:IPR012337,38.0,2257.0,0.9753860202556867,0.2756840942078076,0.016836508639787327,0.02631578947368421,16.374184227026888,15.0,20.0,181.77134146341461,7.123835713789121e-32,RAG1/Transib aromatic beta-strand motif,True,assigned_and_evaluated +6059,30398,15.62583,0.67871094,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.63183594,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6322755605925685,0.2535445281346921,0.004873726185201595,0.2727272727272727,52.02272727272728,13.0,13.0,72.00603864734299,1.9317143050495217e-24,ABC/AAA+ P-loop ATPase core,True,assigned_and_evaluated +6060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HMG-CoA reductase catalytic core,False,no_term_above_threshold +6061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS beta-sheet hydrophobic core,False,no_term_above_threshold +6062,47128,17.228651,0.9394531,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9394531,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,9.0,20.0,115.64418103448276,6.863656579876728e-17,Extracellular low-complexity repeats,True,assigned_too_few_test_positives +6063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long alpha-helical solenoid scaffolds,False,no_term_above_threshold +6064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic accessory domains,False,no_term_above_threshold +6065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic FG-rich low-complexity IDRs,False,no_term_above_threshold +6066,55053,16.092428,0.93847656,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.93847656,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,14.0,0.0,1.0,PBP/β-lactamase SXXK dyad,True,assigned_too_few_test_positives +6067,48767,15.66193,0.86621094,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.86621094,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,16.0,0.0,1.0,N-terminal leader activation,True,assigned_too_few_test_positives +6068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed Gly/Ser/Thr segments,False,no_term_above_threshold +6069,66234,20.890272,0.8574219,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.8574219,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,9.0,16.0,133.08258928571428,1.0257064955522624e-17,N-terminal pre-Cys gating segment,True,assigned_too_few_test_positives +6070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site pocket loops,False,no_term_above_threshold +6071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure junction hinges,False,no_term_above_threshold +6072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal auxiliary domain signature,False,no_term_above_threshold +6073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed polar flexible segments,False,no_term_above_threshold +6074,88058,33.22003,0.6767578,Signal,keyword,88058,Signal,0.6767578,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6991131486890128,0.15300323033046184,0.09127159946832078,,1.6763509264847203,3.0,20.0,1.0807432024169183,0.8334769282943363,Signal peptide and motif detector,True,assigned_and_evaluated +6075,85664,20.93897,0.9526367,Glycogen Phosphorylase B;,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.66748047,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,REC beta5 hydrophobic signal,True,assigned_too_few_test_positives +6076,28622,16.70245,0.8935547,transposase activity,go_mf,88163,Transposable element,0.72021484,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.9984902309058615,0.4411111111111111,0.002215330084182543,1.0,199.11755555555558,2.0,16.0,143.31971153846152,0.0001620913978628739,Charged Zn-finger flanking regions,True,assigned_and_evaluated +6077,85364,17.623352,0.96875,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.96875,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,Helix-coil junction turns,True,assigned_too_few_test_positives +6078,87882,24.775862,0.8071289,Palmitate,keyword,88058,Signal,0.66503906,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9863764252924626,0.2808820808820809,0.002658396101019052,0.16666666666666666,105.65847609180942,8.0,19.0,28.048691561305496,3.4090910926511096e-10,Gram-positive Sec signal peptides,True,assigned_and_evaluated +6079,88009,25.66599,0.6875,Repeat,keyword,88009,Repeat,0.6875,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7172019391001363,0.20562832747471615,0.07266282676118742,,2.8298971653075267,13.0,20.0,5.762624535315985,3.390409932462349e-08,Disordered low-complexity tandem repeats,True,assigned_and_evaluated +6080,37071,18.985834,0.9667969,Homeodomain,interpro,87384,DNA-binding,0.7402344,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,19.0,0.0,1.0,HTH recognition helix detector,True,assigned_too_few_test_positives +6081,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted CAZyme active-site surfaces,False,no_term_above_threshold +6082,24974,17.832432,0.7285156,nucleolus,go_cc,88020,Ribonucleoprotein,0.64746094,141,go,GO:0005730,go_cc:go:GO:0005730,12.0,2257.0,0.6010022271714922,0.10306993542136984,0.005316792202038104,0.08333333333333333,19.385737020502642,12.0,19.0,25.80902564842538,4.43506600311381e-15,Basic disordered RNA-binding tails,True,assigned_and_evaluated +6083,47717,17.287418,0.8696289,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.62060547,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,15.0,16.0,256.3976490825688,1.46477025389507e-35,SF2 helicase interlobe linker,True,assigned_too_few_test_positives +6084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-JmjC active-site cap,False,no_term_above_threshold +6085,37690,19.870064,0.9160156,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.90527344,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9362539682539683,0.031344989240596394,0.0031014621178555605,,10.106520102289437,0.0,13.0,0.0,1.0,Helix-to-beta C-cap motif,True,assigned_and_evaluated +6086,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered envelope linkers,False,no_term_above_threshold +6087,82716,17.749937,0.94140625,Laminin,gene3d,82716,Laminin,0.94140625,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,1.0,17.0,17.024842946887492,0.09394276939466248,Gram-positive cell-surface G5/MucBP repeats,True,assigned_too_few_test_positives +6088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-utilizing enzyme signature,False,no_term_above_threshold +6089,37341,23.798418,0.9897461,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97509766,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9980900182693905,0.7829198487302733,0.011962782454585734,1.0,65.44629994756396,12.0,16.0,109.06280487804878,4.788945430708904e-23,F-box/WD and scaffold IDRs,True,assigned_and_evaluated +6090,45551,16.637375,0.77197266,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.77197266,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,10.0,0.0,1.0,N-terminal leader and strand-helix module,True,assigned_too_few_test_positives +6091,81685,16.413834,0.9555664,Transferase(Phosphotransferase) domain 1,gene3d,87601,Hydrolase,0.6459961,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9559948032665182,0.07426433900039661,0.005316792202038104,,13.967884426991262,0.0,17.0,0.0,1.0,Aromatic catalytic loop motifs,True,assigned_and_evaluated +6092,36886,18.206219,0.75146484,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.75146484,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.7462761227212094,0.15415321644829844,0.003544528134692069,,43.490476190476194,0.0,13.0,0.0,1.0,Aromatic TM helix interface,True,assigned_and_evaluated +6093,38317,25.123785,0.9995117,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.75878906,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9998730158730159,0.9682539682539683,0.0031014621178555605,1.0,312.19274376417235,8.0,9.0,341.91254480286733,4.0645418073796526e-20,C-terminal low-complexity tails,True,assigned_and_evaluated +6094,87277,16.68724,0.65722656,Cell outer membrane,keyword,87277,Cell outer membrane,0.65722656,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.7746666666666666,0.10497650859437178,0.0031014621178555605,,33.84742569964244,9.0,20.0,65.92002457002458,1.0757502956029264e-14,Gly/Pro-rich disordered repeats,True,assigned_and_evaluated +6095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-lumenal N-terminal regulatory tails,False,no_term_above_threshold +6096,64620,16.755762,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,36104,Rho GTPase-activating protein domain,0.9223633,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,13.0,13.0,324.0271739130435,6.732438687398739e-33,HATPase_c ATP-lid turn,True,assigned_too_few_test_positives +6097,49230,18.928745,0.65771484,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.65771484,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,12.0,16.0,210.92334905660377,1.707326609313123e-26,Acyltransferase acceptor-site scaffold,True,assigned_too_few_test_positives +6098,85762,32.791622,0.9199219,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9145508,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,9.0,16.0,115.64418103448276,3.6476853784120264e-17,Rossmann cofactor-binding loops,True,assigned_too_few_test_positives +6099,58239,18.400845,0.60595703,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.60595703,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.632634190347316,0.15147175174560687,0.017722640673460344,0.125,8.546793592245868,15.0,15.0,35.851473241130485,1.3063198800490947e-23,P-loop C-terminal base-coupling region,True,assigned_and_evaluated +6100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic coiled-coils,False,no_term_above_threshold +6101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Threonine-rich low-complexity segments,False,no_term_above_threshold +6102,48767,28.228739,0.9326172,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9326172,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,17.0,0.0,1.0,Active-site phosphate-binding glycine loop,True,assigned_too_few_test_positives +6103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pore-lining TM helices,False,no_term_above_threshold +6104,83419,17.45871,0.97314453,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.96484375,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,17.0,20.0,309.01128048780487,1.3477469128397606e-40,Trp-centered glycan-binding loops,True,assigned_too_few_test_positives +6105,87326,23.07465,0.6430664,Coiled coil,keyword,87326,Coiled coil,0.6430664,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.688601310170405,0.26871009195218554,0.03943287549844927,0.2696629213483146,6.814367163326773,12.0,19.0,7.962649274910685,3.711630408803415e-09,Acidic coiled-coil IDR tails,True,assigned_and_evaluated +6106,50338,19.394226,0.99853516,"GPCR, rhodopsin-like, 7TM",interpro,88152,Transducer,0.8671875,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,17.0,19.0,350.95463988919664,6.066022915868751e-42,GPCR TM3-ICL2 hinge,True,assigned_too_few_test_positives +6107,45290,29.641773,0.9785156,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9785156,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9980117921294391,0.8840962015651841,0.0057598582188746125,0.8461538461538461,153.49270207174004,13.0,13.0,73.42487684729065,1.5015230993598282e-24,Kinase N-lobe boundary motif,True,assigned_and_evaluated +6108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase core alpha-helices,False,no_term_above_threshold +6109,88058,23.761673,0.6166992,Signal,keyword,88058,Signal,0.6166992,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6339223584990509,0.11927055743611333,0.09127159946832078,,1.3067652822005231,3.0,20.0,1.0807432024169183,0.8334769282943363,Mixed-charge disordered hotspots,True,assigned_and_evaluated +6110,85649,32.104797,0.86328125,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.86083984,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8613327624459928,0.5557151039373103,0.0101905183872397,0.5652173913043478,54.532564764630834,14.0,14.0,110.61410018552876,7.27210921345717e-29,SAM-MTase core-adjacent aromatic/hydrophobic segments,True,assigned_and_evaluated +6111,63951,21.574636,0.9423828,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.90234375,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9955516014234875,0.400892680304445,0.003987594151528578,0.5555555555555556,100.53497549412583,0.0,16.0,0.0,1.0,Ectodomain β-sandwich strand–loop motifs,True,assigned_and_evaluated +6112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calmodulin-binding basic amphipathic helices,False,no_term_above_threshold +6113,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteolytic cleavage junctions and linkers,False,no_term_above_threshold +6114,88006,15.830068,0.76123047,Receptor,keyword,88161,Transmembrane helix,0.6879883,160,keywords,Receptor,keyword:keywords:Receptor,10.0,2257.0,0.7048509123275479,0.021670470830571498,0.004430660168365086,,4.891025266459987,2.0,16.0,7.221535852713178,0.05088261614787128,Single-pass signal-anchor helices,True,assigned_and_evaluated +6115,87489,25.291325,0.9057617,GPI-anchor,keyword,87522,Glycoprotein,0.63427734,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8454603174603175,0.15492504489611528,0.0031014621178555605,0.14285714285714285,49.95226090436174,3.0,19.0,23.244054580896687,0.0004999571523881792,Mucin-like juxtamembrane linkers,True,assigned_and_evaluated +6116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-peptide cores and IDRs,False,no_term_above_threshold +6117,87432,16.782318,0.72509766,Endoplasmic reticulum,keyword,88161,Transmembrane helix,0.6147461,210,keywords,Endoplasmic reticulum,keyword:keywords:Endoplasmic reticulum,37.0,2257.0,0.6301740930119308,0.09741524852549784,0.01639344262295082,0.05405405405405406,5.942330160055367,14.0,20.0,20.825698602794407,1.734247343005511e-16,Terminal membrane anchor helices,True,assigned_and_evaluated +6118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic alpha-helical scaffold,False,no_term_above_threshold +6119,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNB exoribonuclease C-terminal core,False,no_term_above_threshold +6120,36354,16.61841,0.99902344,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.99853516,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,18.0,19.0,203.17644831503216,1.1222163336591295e-40,RRM RNP1 glycine-aromatic motif,True,assigned_too_few_test_positives +6121,45288,23.293592,0.9838867,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9838867,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,15.0,15.0,462.17829457364337,3.960299025280445e-40,REC Asp+1-3 loop,True,assigned_too_few_test_positives +6122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDR detector,False,no_term_above_threshold +6123,38873,20.784206,0.7949219,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6479492,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7976021314387212,0.500886132033673,0.002215330084182543,0.6,226.10000000000002,12.0,12.0,171.32471264367817,4.232415391986194e-27,ABC NBD post-Walker B helix,True,assigned_and_evaluated +6124,37282,21.380407,0.9863281,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.92089844,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,LRR N-terminal cap,True,assigned_too_few_test_positives +6125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered PTM/cleavage SLiMs,False,no_term_above_threshold +6126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered nucleic acid regulatory tails,False,no_term_above_threshold +6127,49116,18.444487,0.8330078,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8330078,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9938721136767318,0.2048955405591778,0.002215330084182543,,92.48984700841287,3.0,17.0,15.35963933018463,0.0016021339840228872,Coiled-coil and alpha-solenoid scaffolds,True,assigned_and_evaluated +6128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulatory domain-edge linkers,False,no_term_above_threshold +6129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue loop/turn signature,False,no_term_above_threshold +6130,48880,19.06222,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,87986,Pyridoxal phosphate,0.8305664,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,19.0,19.0,484.7235772357723,2.572132453150849e-50,PLP phosphate-binding N-cap motif,True,assigned_too_few_test_positives +6131,88164,16.215372,0.8535156,Transposition,keyword,46274,Ribonuclease H-like superfamily,0.83984375,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8953818827708703,0.5171097326835031,0.002215330084182543,0.8,233.42333333333332,7.0,15.0,339.30650406504066,1.1017380919033576e-16,Conserved hydrophobic beta-strand motif,True,assigned_and_evaluated +6132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic lipid headgroup enzymes,False,no_term_above_threshold +6133,36354,19.425133,0.9946289,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9921875,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,3.0,17.0,37.84659331358443,0.00011900428953645154,Beta-to-alpha transition peaks,True,assigned_too_few_test_positives +6134,61392,30.076593,0.99902344,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.99902344,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9985396825396825,0.5118274582560297,0.0031014621178555605,1.0,165.02779618340844,13.0,13.0,167.4747191011236,3.5629175766616453e-29,LRR entry cap segment,True,assigned_and_evaluated +6135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPT16 VKDxxE helix-strand-helix,False,no_term_above_threshold +6136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TetR C-terminal regulatory helical bundle,False,no_term_above_threshold +6137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature secreted domain detector,False,no_term_above_threshold +6138,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter transmembrane helical hairpins,False,no_term_above_threshold +6139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase active-site loop motifs,False,no_term_above_threshold +6140,82716,16.240168,0.98583984,Laminin,gene3d,87413,Disulfide bond,0.76464844,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,8.0,16.0,144.71116504854368,5.310508200325819e-16,Extracellular cysteine-rich repeats,True,assigned_too_few_test_positives +6141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble/extracellular beta-strand junctions,False,no_term_above_threshold +6142,32577,16.998146,0.8100586,protein heterodimerization activity,go_mf,25169,pilus,0.6899414,39,go,GO:0046982,go_mf:go:GO:0046982,,,,,,,,13.0,16.0,119.3154248768473,9.562624964935289e-26,CENP-S/MHF1 histone-fold activation,True,assigned_too_few_test_positives +6143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface junction motifs,False,no_term_above_threshold +6144,82608,28.020662,0.9995117,Ankyrin repeat-containing domain,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.99902344,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,1.0,1.0,0.003544528134692069,1.0,282.125,19.0,19.0,170.34571428571428,2.891718859647624e-42,Ankyrin repeat B-helix hydrophobe,True,assigned_and_evaluated +6145,47529,29.89237,0.9848633,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9848633,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9951751450245426,0.57973984470695,0.007089056269384138,0.9375,81.77955184397413,11.0,20.0,42.53119325551233,5.677316743080276e-16,PKD edge-strand Ser/Thr/Ala motifs,True,assigned_and_evaluated +6146,87882,26.836063,0.85546875,Palmitate,keyword,88058,Signal,0.8383789,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9704575744113727,0.05612891559356237,0.002658396101019052,,21.11382708244504,1.0,20.0,3.330782122905028,0.4102914358840034,N-terminal secretory signal peptide,True,assigned_and_evaluated +6147,38878,16.104671,0.98583984,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.95751953,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,7.0,18.0,86.83874323761964,2.237375140136008e-12,PKD domain beta-strand,True,assigned_too_few_test_positives +6148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topoisomerase/polymerase phosphate catalysis,False,no_term_above_threshold +6149,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid recognition helix,False,no_term_above_threshold +6150,36886,23.719387,0.98876953,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.98876953,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9886616273899511,0.1484630514673208,0.003544528134692069,,41.885138395217886,0.0,11.0,0.0,1.0,HAMP/MCP hydrophobic helical core,True,assigned_and_evaluated +6151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic N-terminal localization leaders,False,no_term_above_threshold +6152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature soluble-domain activation,False,no_term_above_threshold +6153,38873,17.22585,0.9267578,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.76904297,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9905861456483126,0.5320434921650143,0.002215330084182543,0.6,240.1644323632875,9.0,9.0,171.32471264367817,1.8650004750458193e-20,ABC NBD coupling helix,True,assigned_and_evaluated +6154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble catalytic ligand clefts,False,no_term_above_threshold +6155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA-like helicase ATPase core,False,no_term_above_threshold +6156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Upstream noncatalytic acyltransferase helix,False,no_term_above_threshold +6157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C membrane-interface catalytic loops,False,no_term_above_threshold +6158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil allosteric couplers,False,no_term_above_threshold +6159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulatory S/T-rich IDRs,False,no_term_above_threshold +6160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB C-terminal YP(x)R motif,False,no_term_above_threshold +6161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal transmembrane alpha-helices,False,no_term_above_threshold +6162,31094,16.294172,0.9472656,phosphopantetheine binding,go_mf,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7832031,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9979528259902092,0.7879329004329003,0.004430660168365086,0.7,177.83645562770562,0.0,14.0,0.0,1.0,AdoMet cofactor-binding core,True,assigned_and_evaluated +6163,49236,25.01901,0.98095703,C-type lectin fold,interpro,49236,C-type lectin fold,0.98095703,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,11.0,14.0,425.8642857142857,6.19367129374213e-28,Extracellular aromatic–cysteine micro-motif,True,assigned_and_evaluated +6164,64148,33.622795,0.89697266,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8442383,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8788862236019002,0.33120868088676475,0.008418254319893664,0.2631578947368421,39.344104882180424,9.0,17.0,47.11053555750659,1.3735305990960065e-13,Exposed assembly interaction regions,True,assigned_and_evaluated +6165,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged alpha-helical interaction scaffolds,False,no_term_above_threshold +6166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VQ(D/E)NH substrate-binding strand,False,no_term_above_threshold +6167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PPIase catalytic pocket motif,False,no_term_above_threshold +6168,85664,15.963811,0.9472656,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.87158203,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,1.0,16.0,20.70173611111111,0.07795292626364224,Conserved internal β-strand motif,True,assigned_too_few_test_positives +6169,85672,33.915924,0.93603516,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9267578,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.928266796738206,0.4094093074282322,0.01595037660611431,0.2777777777777778,25.667689079597782,5.0,10.0,20.007046979865773,4.1830666723973525e-06,Beta-strand -4 hydrophobic anchor,True,assigned_and_evaluated +6170,59224,15.55713,0.8808594,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78466797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9736507936507937,0.066365456919347,0.0031014621178555605,,21.398119466709456,1.0,13.0,10.567352002835873,0.1470148281794519,Helix-cap connector loops near motifs,True,assigned_and_evaluated +6171,36535,21.32645,0.9819336,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9765625,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9982643524699599,0.8967391304347826,0.004430660168365086,0.9,202.39402173913044,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase N-lobe P-loop hairpin,True,assigned_and_evaluated +6172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLiM-rich disordered C-tail,False,no_term_above_threshold +6173,38654,17.72337,1.0,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,1.0,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,5.0,15.0,325.7978142076503,6.148980951584773e-12,Extended boundary segment activation,True,assigned_too_few_test_positives +6174,84152,19.55729,0.8378906,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8378906,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,18.0,499.96645702306074,5.156133401549372e-42,Metal/acid-base catalytic cleft,True,assigned_too_few_test_positives +6175,37468,20.315393,0.98876953,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.92529297,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,5.0,15.0,45.79185867895545,1.1166721199755168e-07,Cys/His zinc-binding motifs,True,assigned_too_few_test_positives +6176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse activation in small proteins,False,no_term_above_threshold +6177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical metal-binding active sites,False,no_term_above_threshold +6178,87857,28.26697,0.7324219,Nucleus,keyword,87857,Nucleus,0.7324219,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7676433522369249,0.2439817651717887,0.06247230837394772,,3.9054386098774976,18.0,19.0,5.7401476251604615,2.930157346962097e-13,Nuclear basic/polar low-complexity IDRs,True,assigned_and_evaluated +6179,61392,16.46136,0.8515625,Leucine-rich repeat domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7607422,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.7982857142857143,0.01898849403656433,0.0031014621178555605,,6.122433005789384,0.0,15.0,0.0,1.0,SF4 helicase dNTP-coordinating strand,True,assigned_and_evaluated +6180,64596,29.682163,0.98535156,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.98535156,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,7.0,13.0,330.9651070578906,9.947894571998115e-17,Metalloenzyme active-site lid,True,assigned_too_few_test_positives +6181,59224,34.849186,0.97998047,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97998047,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,20.0,20.0,137.37557603686636,1.3818410501239142e-42,AB hydrolase acid loop,True,assigned_and_evaluated +6182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metallopeptidase domain scaffold,False,no_term_above_threshold +6183,87697,20.205685,0.8720703,Knottin,keyword,87697,Knottin,0.8720703,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.947619708214839,0.13319642551193556,0.017279574656623838,,7.708316214883039,0.0,15.0,0.0,1.0,Small-residue helix/active-site hotspots,True,assigned_and_evaluated +6184,52236,17.544544,0.98583984,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9824219,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,13.0,20.0,145.14475655430712,5.143549029061587e-26,Helical repeat core hydrophobics,True,assigned_too_few_test_positives +6185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipovitellin and capsid jellyroll scaffold,False,no_term_above_threshold +6186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix interface motifs,False,no_term_above_threshold +6187,81858,19.765121,0.875,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.875,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Loop-to-TM helix N-cap,True,assigned_too_few_test_positives +6188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FlhA cytoplasmic EPxFG motif,False,no_term_above_threshold +6189,85664,17.168468,0.9555664,Glycogen Phosphorylase B;,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.74121094,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,16.0,0.0,1.0,REC domain switch-loop residues,True,assigned_too_few_test_positives +6190,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease zymogen maturation seam,False,no_term_above_threshold +6191,85672,19.068474,0.7607422,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.75439453,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8487105407974386,0.0948448585039149,0.01595037660611431,,5.946245712314887,0.0,15.0,0.0,1.0,Helix caps and linkers,True,assigned_and_evaluated +6192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ala/Gly/Arg-rich low-complexity IDRs,False,no_term_above_threshold +6193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Buried hydrophobic core residues,False,no_term_above_threshold +6194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short terminal hinge/interface segments,False,no_term_above_threshold +6195,87149,20.20943,0.69091797,Amphibian defense peptide,keyword,88058,Signal,0.66748047,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7409632762930206,0.04622112457811311,0.012405848471422242,,3.72575279188576,0.0,15.0,0.0,1.0,Sec-exported mature-domain hotspots,True,assigned_and_evaluated +6196,29104,16.492062,0.69873047,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.69873047,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,10.0,10.0,428.9280575539568,1.0967045620706512e-26,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +6197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered S/T-rich regulatory tails,False,no_term_above_threshold +6198,87326,21.033764,0.6113281,Coiled coil,keyword,87326,Coiled coil,0.6113281,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6732477507359345,0.21837276184494026,0.03943287549844927,0.21348314606741572,5.537835095326182,19.0,20.0,11.977151617678155,5.677614873654298e-20,Extended cross-domain assembly linkers,True,assigned_and_evaluated +6199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor hairpin module,False,no_term_above_threshold +6200,87274,16.000214,0.62841797,Cell inner membrane,keyword,87276,Cell membrane,0.6064453,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.8333560275962236,0.6744451400366813,0.0358883473637572,0.6666666666666666,18.792872605713455,9.0,17.0,20.643596352864233,1.9897248069402218e-10,Transmembrane helix-loop connectors,True,assigned_and_evaluated +6201,37468,19.591784,0.98046875,"Zinc finger, RING-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.95703125,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,16.0,0.0,1.0,Localized helix/strand anchor,True,assigned_too_few_test_positives +6202,81685,17.288038,0.95703125,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9301758,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9910727542687454,0.8316850211985092,0.005316792202038104,0.8333333333333334,156.4260910704196,4.0,17.0,20.155848546315077,7.15188917363895e-05,Short hydrophobic β-strand motif,True,assigned_and_evaluated +6203,48241,15.636552,0.81689453,RmlC-like jelly roll fold,interpro,27918,DNA-binding transcription factor activity,0.6088867,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,9.0,19.0,183.38653451811345,9.16149889176504e-19,N-terminal domain-edge signal,True,assigned_too_few_test_positives +6204,82029,31.135702,0.99365234,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.98583984,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,18.0,156.7323869610936,1.8278507282603615e-31,MFS cytosolic TM6-7 loop,True,assigned_too_few_test_positives +6205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad domain-level activation,False,no_term_above_threshold +6206,58239,25.970522,0.671875,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.671875,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6688768606224628,0.22725036970764928,0.017722640673460344,0.2,12.822602110754111,13.0,15.0,31.071276808979754,1.473710990017574e-18,P-loop NTPase helical lid/collar,True,assigned_and_evaluated +6207,50806,20.81347,0.89501953,"Homeobox, conserved site",interpro,37071,Homeodomain,0.8691406,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,CBS/Bateman and CBS-like motifs,True,assigned_too_few_test_positives +6208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged solvent-exposed interaction patches,False,no_term_above_threshold +6209,87326,27.840967,0.67578125,Coiled coil,keyword,87326,Coiled coil,0.67578125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7088317301712344,0.337077918602345,0.03943287549844927,0.39325842696629215,8.548144520061715,9.0,20.0,5.673387608373863,1.7242167518932853e-05,Phospho-regulated acidic S/T IDRs,True,assigned_and_evaluated +6210,64003,24.23034,0.92578125,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.90185547,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9999011466982998,0.9765432098765434,0.003987594151528578,1.0,244.8953360768176,19.0,19.0,130.4617067833698,3.819237356487831e-40,Disordered C2H2 effector regions,True,assigned_and_evaluated +6211,37020,16.21278,0.9448242,"Glycosyl transferase, family 1",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7036133,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,9.0,0.0,1.0,ABC NBD coil-to-beta hinge,True,assigned_too_few_test_positives +6212,81685,22.719938,0.9711914,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96972656,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9572754268745359,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,17.0,17.0,85.66235632183908,5.1673760881485446e-33,Kinase pre-DFG motif,True,assigned_and_evaluated +6213,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rap-GAP catalytic domain detector,False,no_term_above_threshold +6214,88164,22.87861,0.90185547,Transposition,keyword,88164,Transposition,0.90185547,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8974245115452931,0.5171097326835031,0.002215330084182543,0.8,233.42333333333332,2.0,16.0,90.88567073170732,0.0003988394211171349,FAR1-MULE linker hotspots,True,assigned_and_evaluated +6215,86130,19.12865,0.90966797,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.90771484,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9263809523809525,0.8218716374454078,0.0031014621178555605,0.8571428571428571,264.9948979591836,17.0,19.0,215.1012308998302,2.2723844675242367e-38,Cytosolic regulatory interaction domains,True,assigned_and_evaluated +6216,36010,18.470371,0.98535156,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97314453,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,1.0,16.0,31.84882478632479,0.051452799217336594,Alpha/beta-hydrolase catalytic Asp segment,True,assigned_too_few_test_positives +6217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-domain-adjacent helix/loop segments,False,no_term_above_threshold +6218,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RGG-rich RNA-binding IDRs,False,no_term_above_threshold +6219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic pocket-edge interface loops,False,no_term_above_threshold +6220,64155,23.415195,0.8779297,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.8618164,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,0.0,16.0,0.0,1.0,DDE transposase hydrophobic beta-strands,True,assigned_too_few_test_positives +6221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed beta-edge/helix caps,False,no_term_above_threshold +6222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LysM glycan-binding module,False,no_term_above_threshold +6223,64475,22.70479,0.9951172,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.9633789,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9999314411079117,0.9885883347421807,0.0057598582188746125,1.0,171.6341439625463,12.0,17.0,375.76260504201684,2.36154640205427e-29,Conserved catalytic anchor residues,True,assigned_and_evaluated +6224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic N-termini of outer-membrane transporters,False,no_term_above_threshold +6225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap surface motif,False,no_term_above_threshold +6226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal NAD(P)H-binding loops,False,no_term_above_threshold +6227,64058,18.447468,0.7944336,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.79248047,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9500987198267626,0.25462891003623345,0.006202924235711121,,41.04981785369849,2.0,15.0,15.199745060548118,0.012797213476436363,Charged helix-coil cap/hinge,True,assigned_and_evaluated +6228,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered phospho-tails and metal sites,False,no_term_above_threshold +6229,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIM-barrel substrate-binding motif,False,no_term_above_threshold +6230,37894,18.316303,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,85656,alpha/beta hydrolase,0.8574219,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR catalytic YXXXK helix,True,assigned_too_few_test_positives +6231,52236,21.432991,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9916992,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR helix-A ladder residue,True,assigned_too_few_test_positives +6232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DEAH helicase interdomain motif,False,no_term_above_threshold +6233,85664,22.890192,0.9794922,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9794922,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycosyltransferase donor-binding loops,True,assigned_too_few_test_positives +6234,87697,17.74811,0.82470703,Knottin,keyword,87413,Disulfide bond,0.65966797,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9570183348361888,0.23722169840692925,0.017279574656623838,,13.728445469344598,0.0,18.0,0.0,1.0,Strand/helix-to-coil turns,True,assigned_and_evaluated +6235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic pocket-gating loop SLiM,False,no_term_above_threshold +6236,85664,16.639229,0.9355469,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9355469,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,11.0,0.0,1.0,Soluble short surface alpha-helices,True,assigned_too_few_test_positives +6237,82107,19.39384,0.74609375,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.7402344,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,20.0,0.0,1.0,Disordered N-terminal targeting regions,True,assigned_too_few_test_positives +6238,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse pan-protein activation,False,no_term_above_threshold +6239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine/glycan-rich extracellular loops,False,no_term_above_threshold +6240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase N-domain activation,False,no_term_above_threshold +6241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic amphipathic helices and tails,False,no_term_above_threshold +6242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RTX/beta-roll Ca2+-binding repeats,False,no_term_above_threshold +6243,88240,16.38828,0.6147461,Virulence,keyword,88240,Virulence,0.6147461,306,keywords,Virulence,keyword:keywords:Virulence,20.0,2257.0,0.631783638801967,0.048660286613286266,0.008861320336730172,,5.491313344309355,15.0,18.0,29.84034034034034,9.23078762042558e-21,N-terminal leader/propeptide signals,True,assigned_and_evaluated +6244,88161,34.847713,0.6123047,Transmembrane helix,keyword,88159,Transmembrane,0.61035156,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6064819883223856,0.3086085003439362,0.1847585290208241,0.2709832134292566,1.670334257257228,14.0,20.0,3.799244424214838,1.2489710488615452e-06,Viral signal-anchor helices,True,assigned_and_evaluated +6245,36115,16.291063,0.77783203,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7529297,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,14.0,0.0,1.0,PAS/LOV/CACHE beta-strand cores,True,assigned_too_few_test_positives +6246,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rieske C-terminal linker activation,False,no_term_above_threshold +6247,86137,15.763942,0.7055664,Helix-loop-helix DNA-binding domain,gene3d,86137,Helix-loop-helix DNA-binding domain,0.7055664,40,gene3d,4.10.280.10,gene3d:gene3d:4.10.280.10,,,,,,,,0.0,12.0,0.0,1.0,Charged N-terminal helix boundary,True,assigned_too_few_test_positives +6248,88161,55.9403,0.67285156,Transmembrane helix,keyword,88161,Transmembrane helix,0.67285156,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.645329605880513,0.38936033097899014,0.1847585290208241,0.33573141486810554,2.107401119951033,19.0,19.0,5.4274920345926265,2.5090631899926267e-14,Hydrophobic transmembrane helix anchor,True,assigned_and_evaluated +6249,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase E/G catalytic core hotspot,False,no_term_above_threshold +6250,82029,16.88203,0.75097656,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.74121094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,14.0,0.0,1.0,Structured cores and transmembranes,True,assigned_too_few_test_positives +6251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal membrane-targeting motifs,False,no_term_above_threshold +6252,82764,17.764265,0.9248047,Kelch-type beta propeller,gene3d,82764,Kelch-type beta propeller,0.9248047,38,gene3d,2.120.10.80,gene3d:gene3d:2.120.10.80,,,,,,,,0.0,15.0,0.0,1.0,RCC1/NHL beta-blade motif,True,assigned_too_few_test_positives +6253,36876,16.362226,0.91015625,Cytochrome P450,interpro,36876,Cytochrome P450,0.91015625,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9416271253459866,0.39535541487655373,0.003987594151528578,0.7777777777777778,99.14635237515354,0.0,15.0,0.0,1.0,Cofactor-adjacent catalytic loop,True,assigned_and_evaluated +6254,87108,20.170086,0.8925781,ANK repeat,keyword,88009,Repeat,0.77978516,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9154310003954131,0.07382278570741442,0.003987594151528578,,18.513114149070486,0.0,13.0,0.0,1.0,Repeat domain fold core,True,assigned_and_evaluated +6255,88163,18.36696,0.6640625,Transposable element,keyword,43624,Homedomain-like superfamily,0.6586914,122,keywords,Transposable element,keyword:keywords:Transposable element,11.0,2257.0,0.7197037156965919,0.18085103679365974,0.004873726185201595,0.09090909090909091,37.10734454939001,5.0,18.0,71.6943241943242,1.3870277350934313e-08,Conserved interface alpha helix,True,assigned_and_evaluated +6256,38873,22.102737,0.9091797,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7871094,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.894227353463588,0.1641283055085276,0.002215330084182543,,74.08751710654937,3.0,20.0,25.698706896551723,0.00037677026635407905,Focal conserved hydrophobic hVIFLT[D/E/N] motif,True,assigned_and_evaluated +6257,48883,17.587677,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,Conserved PLP core helix,True,assigned_too_few_test_positives +6258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RMD-like internal α/β signature,False,no_term_above_threshold +6259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity regulatory segments,False,no_term_above_threshold +6260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic oligomerization interface helices,False,no_term_above_threshold +6261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ANL AMP-binding signature loop,False,no_term_above_threshold +6262,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PH-like and beta-sandwich regulatory domains,False,no_term_above_threshold +6263,72011,16.5474,0.99560547,"AMP-binding enzyme, C-terminal domain superfamily",interpro,46284,FMN-binding split barrel,0.91845703,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,13.0,0.0,1.0,EAL catalytic β-strand motif,True,assigned_too_few_test_positives +6264,37097,25.393665,0.95166016,Cro/C1-type helix-turn-helix domain,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.88623047,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,10.0,20.0,281.2311320754717,1.0380705425504895e-22,N-terminal disordered basic tails,True,assigned_too_few_test_positives +6265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular/cell-surface protein signature,False,no_term_above_threshold +6266,38873,17.785833,0.73046875,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6254883,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.5965364120781527,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,8.0,11.0,124.59979101358412,4.824531533129992e-16,ASCE P-loop NTPase motors,True,assigned_and_evaluated +6267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytoplasmic C-terminal tails,False,no_term_above_threshold +6268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic phosphorylation-rich degron IDRs,False,no_term_above_threshold +6269,61392,16.43926,0.8076172,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.8076172,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.8207619047619049,0.026195268858331542,0.0031014621178555605,,8.446103116179184,0.0,14.0,0.0,1.0,Beta-solenoid N-cap turns,True,assigned_and_evaluated +6270,84152,25.60919,0.9995117,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9995117,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,His/Asp/Glu metal-binding pocket,True,assigned_too_few_test_positives +6271,88161,80.447044,0.8569336,Transmembrane helix,keyword,88161,Transmembrane helix,0.8569336,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.9117949118965697,0.7772141119762919,0.1847585290208241,0.9040767386091128,4.206648083286549,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,Transmembrane helix boundary anchors,True,assigned_and_evaluated +6272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DEAD-box N-terminal IDR activation,False,no_term_above_threshold +6273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane oxyanion-binding catalytic cores,False,no_term_above_threshold +6274,45288,25.21108,1.0,CheY-like superfamily,interpro,45288,CheY-like superfamily,1.0,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,19.0,19.0,462.17829457364337,6.130283085627497e-50,Two-component switch helix,True,assigned_too_few_test_positives +6275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Dehydrogenase N-terminal LGxxENxLG motif,False,no_term_above_threshold +6276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP-loop adenylate ligase core,False,no_term_above_threshold +6277,85364,24.788671,0.84716797,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.84716797,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Periplasmic Venus flytrap SBP fold,True,assigned_too_few_test_positives +6278,87601,16.697876,0.61621094,Hydrolase,keyword,87601,Hydrolase,0.61621094,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6128568086102012,0.10478824932147071,0.05316792202038104,0.016666666666666666,1.9708923226546617,10.0,13.0,8.602946481393301,1.450697200610983e-08,Extracellular catalytic/binding cores,True,assigned_and_evaluated +6279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Crotonase-fold interface loop,False,no_term_above_threshold +6280,30398,15.972371,0.6933594,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6035156,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6261232089371003,0.2535445281346921,0.004873726185201595,0.2727272727272727,52.02272727272728,12.0,12.0,72.00603864734299,1.3232849389198435e-22,ABC NBD N-terminal beta1 strand,True,assigned_and_evaluated +6281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal targeting IDRs,False,no_term_above_threshold +6282,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane β-barrels and AMPs,False,no_term_above_threshold +6283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Death-fold interaction domains,False,no_term_above_threshold +6284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered coiled-coil scaffold assemblies,False,no_term_above_threshold +6285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAIN/GPS-proximal ectodomain,False,no_term_above_threshold +6286,85649,20.23495,0.92041016,Vaccinia Virus protein VP39,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.91015625,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9333521466661477,0.09424139555097419,0.0101905183872397,,9.247949119936901,0.0,16.0,0.0,1.0,"C-terminal aromatic helix, VxTP motif",True,assigned_and_evaluated +6287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich portal loop,False,no_term_above_threshold +6288,88164,18.119905,0.89404297,Transposition,keyword,46274,Ribonuclease H-like superfamily,0.8642578,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.999733570159858,0.925,0.002215330084182543,1.0,417.5450000000001,4.0,20.0,145.41707317073173,3.165231898209611e-08,Amphipathic interface-anchor helix,True,assigned_and_evaluated +6289,38317,19.953054,0.8359375,Pentatricopeptide repeat,interpro,63831,F-box-like domain superfamily,0.78808594,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7015238095238095,0.052046989342071304,0.0031014621178555605,,16.781436420722134,0.0,13.0,0.0,1.0,N-terminal CC and LRR activation,True,assigned_and_evaluated +6290,46079,40.771397,0.9873047,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9873047,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.996160702043055,0.5296260683760684,0.0057598582188746125,0.46153846153846156,91.9512335634451,14.0,18.0,72.45607638888889,2.041690564645909e-24,TPR/alpha-solenoid PPI scaffolds,True,assigned_and_evaluated +6291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic α/β core scaffold,False,no_term_above_threshold +6292,52940,15.587245,0.86279297,"AMP-binding, conserved site",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.8305664,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,19.0,0.0,1.0,N-terminal accessory α/β subdomain,True,assigned_too_few_test_positives +6293,59211,25.808357,0.9892578,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9892578,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.999820788530466,0.9849153262196743,0.011076650420912717,1.0,88.91815565111219,15.0,16.0,229.07658811475412,7.873483886430935e-35,Aromatic-glycine donor-binding loop,True,assigned_and_evaluated +6294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal RHG motif detector,False,no_term_above_threshold +6295,64148,20.574717,0.6796875,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6796875,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6281219133624946,0.15350868864673867,0.008418254319893664,0.10526315789473684,18.23521633029943,19.0,19.0,88.9865671641791,4.383349844353145e-37,Helical effector-binding repressor core,True,assigned_and_evaluated +6296,27013,17.038658,0.7573242,side of membrane,go_cc,87489,GPI-anchor,0.74853516,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.5537538871612617,0.0042233622126965995,0.002658396101019052,,1.5886880856760375,0.0,19.0,0.0,1.0,Proline/alanine-rich disordered linkers,True,assigned_and_evaluated +6297,36535,18.462576,0.91748047,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8964844,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8962616822429906,0.7208861320336729,0.004430660168365086,0.7,162.70399999999998,10.0,10.0,89.79066265060241,7.097379695858549e-20,Cytosolic juxtamembrane basic linker,True,assigned_and_evaluated +6298,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDR-flanked ubiquitin adaptors,False,no_term_above_threshold +6299,50806,22.351587,0.98779297,"Homeobox, conserved site",interpro,87384,DNA-binding,0.66796875,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,HTH recognition helix exit cluster,True,assigned_too_few_test_positives +6300,87913,15.963844,0.9638672,Phosphopantetheine,keyword,87566,Homeobox,0.83935547,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.9569613400420355,0.3754964725568105,0.006202924235711121,0.7142857142857143,60.53539561148009,0.0,15.0,0.0,1.0,PAS and HAMP sensory domains,True,assigned_and_evaluated +6301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-coordinating di-His phosphate motif,False,no_term_above_threshold +6302,55053,17.796516,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,12.0,12.0,552.0462962962963,3.0471251534694055e-33,Fungal NRPS Condensation domain,True,assigned_too_few_test_positives +6303,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-inserting amphipathic helical modules,False,no_term_above_threshold +6304,37097,22.3468,0.97753906,Cro/C1-type helix-turn-helix domain,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.94873047,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,Post-HTH C-terminal helix/tail,True,assigned_too_few_test_positives +6305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted β-solenoid/β-sandwich domains,False,no_term_above_threshold +6306,85664,16.150852,0.97216797,Glycogen Phosphorylase B;,gene3d,59224,Alpha/Beta hydrolase fold,0.90185547,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,17.0,0.0,1.0,Rossmann C-terminal hydrophobic lid,True,assigned_too_few_test_positives +6307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil scaffolds,False,no_term_above_threshold +6308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix termination and TM interfaces,False,no_term_above_threshold +6309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane anchor helices,False,no_term_above_threshold +6310,37097,15.768189,0.8676758,Cro/C1-type helix-turn-helix domain,interpro,27918,DNA-binding transcription factor activity,0.67041016,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,18.0,0.0,1.0,HTH/winged-HTH DNA-binding helices,True,assigned_too_few_test_positives +6311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-acidic glycan-binding clefts,False,no_term_above_threshold +6312,47529,25.709064,0.9267578,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9267578,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9920375948237393,0.47654989621555793,0.007089056269384138,0.25,67.22331973490714,2.0,16.0,9.66618028534371,0.03000963369227314,Transmembrane-edge low-complexity linkers,True,assigned_and_evaluated +6313,84991,15.983586,1.0,3.30.70.20,gene3d,87681,Iron-sulfur,0.7841797,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,13.0,19.0,474.34088127294984,5.490987318581008e-33,Ferredoxin surface docking motifs,True,assigned_too_few_test_positives +6314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/polar oligomerization loops,False,no_term_above_threshold +6315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent His-acidic active sites,False,no_term_above_threshold +6316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered loops with binding motifs,False,no_term_above_threshold +6317,64168,24.023672,0.8886719,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.8886719,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.897335701598579,0.6352256747124887,0.002215330084182543,0.6,286.7408695652174,17.0,17.0,334.9494382022472,7.26757959387553e-43,HAD-like phosphatase cap pocket,True,assigned_and_evaluated +6318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β→α helix-capping hinge loops,False,no_term_above_threshold +6319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic IDR/coiled-coil tethers,False,no_term_above_threshold +6320,38317,19.046705,0.94433594,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7963867,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9194285714285715,0.4868670586908292,0.0031014621178555605,0.42857142857142855,156.9798502093145,1.0,17.0,22.626565464895634,0.07158249603350325,Coiled-coil and alpha-solenoid scaffolds,True,assigned_and_evaluated +6321,85672,17.46607,0.74560547,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7338867,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8650257641702935,0.085429683997555,0.01595037660611431,,5.355966577291157,0.0,17.0,0.0,1.0,Glycine-rich phosphate-binding loops,True,assigned_and_evaluated +6322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,First 2–3 transmembrane helices,False,no_term_above_threshold +6323,87413,58.669594,0.9042969,Disulfide bond,keyword,88058,Signal,0.78808594,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9406862311794693,0.6388960951064557,0.0717766947275144,0.8827160493827161,8.90116349787204,18.0,20.0,10.644495139853204,1.8725375718781506e-17,Secreted disulfide-rich motifs,True,assigned_and_evaluated +6324,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transducing coiled-coil linkers,False,no_term_above_threshold +6325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thiolase KAxxxGQ loop,False,no_term_above_threshold +6326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed beta-strand patches,False,no_term_above_threshold +6327,37468,20.40484,0.97021484,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.90625,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,2.0,20.0,13.737557603686636,0.015711742271564955,Motif-adjacent non-ligating residues,True,assigned_too_few_test_positives +6328,59229,34.189186,0.77197266,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.77197266,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7141606009886731,0.29538439562223995,0.0101905183872397,0.21739130434782608,28.9861991704085,16.0,16.0,106.27629233511585,1.339381655082284e-32,C-terminal substrate-recognition region,True,assigned_and_evaluated +6329,46277,17.414904,0.9145508,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9145508,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.921253946409779,0.06848739517367834,0.004873726185201595,,14.052368264272003,0.0,17.0,0.0,1.0,Aromatic–Pro beta-hairpin turns,True,assigned_and_evaluated +6330,43583,17.77767,0.9692383,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9692383,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,10.0,10.0,416.9300699300699,1.4595016026239996e-26,Serine protease N-terminal activation segment,True,assigned_and_evaluated +6331,87274,19.193651,0.6923828,Cell inner membrane,keyword,88161,Transmembrane helix,0.65185547,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.8082334785766158,0.19436787722086937,0.0358883473637572,,5.415904924537064,7.0,14.0,19.49672988881622,4.201574985180785e-08,Cytosolic juxtamembrane amphipathic helices,True,assigned_and_evaluated +6332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracatalytic beta-sheet regional activation,False,no_term_above_threshold +6333,87239,18.357658,0.88964844,CF(1),keyword,87239,CF(1),0.88964844,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9982118909253465,0.6691217500212654,0.008861320336730172,1.0,75.51038948989981,8.0,16.0,402.8445945945946,1.2519644838692428e-19,Macromolecular assembly interfaces,True,assigned_and_evaluated +6334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Redox assembly docking surfaces,False,no_term_above_threshold +6335,43624,15.890325,0.8198242,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.8198242,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8331520526550648,0.020724428122344464,0.007089056269384138,,2.923439642008216,0.0,16.0,0.0,1.0,Secondary-structure caps and TM boundaries,True,assigned_and_evaluated +6336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and amphipathic helices,False,no_term_above_threshold +6337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PKS DH hotdog fold,False,no_term_above_threshold +6338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAT helical interaction motif,False,no_term_above_threshold +6339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and interfaces,False,no_term_above_threshold +6340,45290,33.23205,0.96777344,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.96777344,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9610928287398877,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,17.0,17.0,73.42487684729065,6.829036441178294e-32,Kinase D-3 beta-strand hydrophobe,True,assigned_and_evaluated +6341,87489,16.369347,0.7944336,GPI-anchor,keyword,88161,Transmembrane helix,0.63623047,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8914920634920636,0.03287452467753763,0.0031014621178555605,,10.599686028171776,0.0,17.0,0.0,1.0,Extracytoplasmic glycoprotein ectodomains,True,assigned_and_evaluated +6342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral assembly interface segments,False,no_term_above_threshold +6343,36449,17.883373,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,14.0,19.0,784.4868421052631,6.146287500115658e-39,Small-molecule transporter TM helices,True,assigned_too_few_test_positives +6344,85364,31.070482,0.9873047,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9873047,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,18.0,284.3874859708193,6.285282157931668e-41,VFT/PBP clamshell lobe segments,True,assigned_too_few_test_positives +6345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Output-coupling S-helix linker,False,no_term_above_threshold +6346,50338,18.925627,0.9980469,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9506836,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,16.0,18.0,348.6608187134503,1.697096145792369e-39,GPCR fourth transmembrane helix,True,assigned_too_few_test_positives +6347,37576,19.14321,0.9916992,"Zinc finger, PHD-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.69189453,31,ip,IPR001965,interpro:ip:IPR001965,,,,,,,,0.0,15.0,0.0,1.0,beta-alpha junction functional belts,True,assigned_too_few_test_positives +6348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and transmembrane helices,False,no_term_above_threshold +6349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helices of lipid-linked transferases,False,no_term_above_threshold +6350,37430,23.641624,0.9995117,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,0.9838867,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,14.0,14.0,484.7235772357723,7.836327138722209e-38,REC β2 Thr-rich motif,True,assigned_too_few_test_positives +6351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal signal-anchor helices,False,no_term_above_threshold +6352,88161,30.722466,0.65478516,Transmembrane helix,keyword,88161,Transmembrane helix,0.65478516,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6750078198310917,0.33522532159692275,0.1847585290208241,0.12470023980815348,1.8143970044226732,15.0,15.0,5.4274920345926265,2.044231257442523e-11,Hydrophobic TM-helix core sites,True,assigned_and_evaluated +6353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,eRF1/Dom34/Pelota whole-protein signature,False,no_term_above_threshold +6354,85656,17.693913,0.9296875,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.78564453,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8433650793650793,0.20388188713476912,0.0031014621178555605,0.14285714285714285,65.73734560902484,5.0,17.0,41.55352662391971,1.9684263692261564e-07,C5 methyltransferase helix motif,True,assigned_and_evaluated +6355,37020,18.09629,0.9848633,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9790039,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,2.0,16.0,102.09075342465754,0.0003177276145020656,Conserved nucleotide-donor catalytic core,True,assigned_too_few_test_positives +6356,88058,20.082382,0.625,Signal,keyword,88058,Signal,0.625,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6148847590330079,0.10837490871933253,0.09127159946832078,,1.1873891698035608,4.0,20.0,1.4409909365558913,0.4670478563492871,Ser/Gly/Pro-rich low-complexity IDRs,True,assigned_and_evaluated +6357,47529,20.612196,0.9536133,Immunoglobulin-like fold,interpro,87413,Disulfide bond,0.6435547,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9757362784471219,0.5358299790917112,0.007089056269384138,0.625,75.5855164256245,17.0,17.0,77.32944228274968,2.872750145145074e-32,Beta-sandwich hydrophobic core residues,True,assigned_and_evaluated +6358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended amphipathic helical segments,False,no_term_above_threshold +6359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase-OB 5'-end module,False,no_term_above_threshold +6360,87857,18.940119,0.6147461,Nucleus,keyword,87857,Nucleus,0.6147461,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6286902224188553,0.1646852024173534,0.06247230837394772,0.07801418439716312,2.636131218836643,16.0,17.0,5.702630320420851,9.35704495932618e-12,N-terminal low-complexity IDRs,True,assigned_and_evaluated +6361,64155,17.150848,0.984375,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9716797,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,10.0,15.0,184.87131782945735,2.401146382430539e-21,Active-site alpha-helices,True,assigned_too_few_test_positives +6362,37690,16.261732,0.8979492,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.8886719,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9207301587301586,0.021834694325323874,0.0031014621178555605,,7.040129298893712,0.0,17.0,0.0,1.0,Kinase domain helix-capping residues,True,assigned_and_evaluated +6363,47529,22.569584,0.91015625,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.91015625,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9440121597501115,0.24079397434117214,0.007089056269384138,0.0625,33.967000005501596,11.0,16.0,53.163991569390404,1.5980107339612975e-17,CLCA ectodomain proline motif,True,assigned_and_evaluated +6364,63960,28.32315,0.9008789,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9008789,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,16.0,16.0,193.57467532467533,1.0288461071936617e-36,FAD/NAD(P)-binding Rossmann flavoprotein subdomain,True,assigned_too_few_test_positives +6365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-binding β–α module,False,no_term_above_threshold +6366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional interface segment,False,no_term_above_threshold +6367,45290,18.471476,0.6479492,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.6479492,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.5944398738516387,0.01087103676789288,0.0057598582188746125,,1.88737922962571,17.0,17.0,73.42487684729065,6.829036441178294e-32,Kinase active-site mouth loop,True,assigned_and_evaluated +6368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil helical bundles,False,no_term_above_threshold +6369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine-based IDR signaling motifs,False,no_term_above_threshold +6370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-biased helix-coil capping,False,no_term_above_threshold +6371,72011,18.886799,0.99560547,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85664,Glycogen Phosphorylase B;,0.98095703,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,18.0,0.0,1.0,Nucleotide-sugar pocket helix,True,assigned_too_few_test_positives +6372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader segments,False,no_term_above_threshold +6373,37312,15.914208,1.0,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",1.0,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,18.0,19.0,818.5949656750571,4.3313349653425253e-51,Helix-loop-helix hinge segments,True,assigned_too_few_test_positives +6374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic SAM/PNT oligomerization helix,False,no_term_above_threshold +6375,87326,27.359371,0.6381836,Coiled coil,keyword,87326,Coiled coil,0.6381836,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.614772067664497,0.08374486451228574,0.03943287549844927,,2.123732125890213,13.0,19.0,8.626203381153243,1.7506259806341123e-10,Acidic coiled-coils and porin loops,True,assigned_and_evaluated +6376,63960,38.338413,0.8979492,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.8979492,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,17.0,17.0,193.57467532467533,6.347107800690125e-39,FAD flavoenzymes and carotenoid cyclases,True,assigned_too_few_test_positives +6377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface-adjacent conserved motifs,False,no_term_above_threshold +6378,36668,19.322977,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,ANL A3 AMP-binding loop,True,assigned_too_few_test_positives +6379,87326,28.63229,0.6538086,Coiled coil,keyword,87326,Coiled coil,0.6538086,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7018533106679382,0.22426268512621625,0.03943287549844927,0.14606741573033707,5.68720090258281,10.0,11.0,11.461389107825987,2.0950800161527166e-10,Domain-scale macromolecular recognition modules,True,assigned_and_evaluated +6380,87970,17.611662,0.8486328,Protein phosphatase,keyword,87970,Protein phosphatase,0.8486328,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,14.0,0.0,1.0,Active-site buttress segment,True,assigned_too_few_test_positives +6381,37312,16.355354,1.0,"DNA-binding HTH domain, TetR-type",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.92041016,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,19.0,19.0,864.0724637681159,5.368526660497688e-55,Amphipathic hinge/linker helices,True,assigned_too_few_test_positives +6382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming and fusion ectodomains,False,no_term_above_threshold +6383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Specificity-determining recognition hotspots,False,no_term_above_threshold +6384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Widespread activation in folded proteins,False,no_term_above_threshold +6385,87882,24.65269,0.8618164,Palmitate,keyword,88058,Signal,0.84716797,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9831926551162447,0.08326753624625965,0.002658396101019052,,31.322471551301337,9.0,20.0,29.977039106145252,1.1677093432116002e-11,Sec signal peptide h-region,True,assigned_and_evaluated +6386,59224,31.216743,0.9716797,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9716797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9999999999999999,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Nucleophile-adjacent β-strand peak,True,assigned_and_evaluated +6387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic Ser/Thr/Pro-rich IDRs,False,no_term_above_threshold +6388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Contiguous structured core segments,False,no_term_above_threshold +6389,88161,36.76242,0.6074219,Transmembrane helix,keyword,88159,Transmembrane,0.60595703,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6953895579188822,0.49344882907701965,0.1847585290208241,0.48201438848920863,2.670776995747802,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Membrane-proximal N-terminal linker,True,assigned_and_evaluated +6390,28025,16.09424,0.83203125,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.65625,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9939286243151192,0.19363044363044363,0.002658396101019052,,72.83731854565187,8.0,10.0,216.80363636363637,3.3619396504587816e-18,NTPase switch-adjacent interfaces,True,assigned_and_evaluated +6391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible β/α hinge regions,False,no_term_above_threshold +6392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic nuclear interaction scaffolds,False,no_term_above_threshold +6393,38317,15.971282,0.8022461,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8022461,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.5218412698412699,0.0044441103867333374,0.0031014621178555605,,1.432908163265306,0.0,14.0,0.0,1.0,N-terminal GS beta-grasp domain,True,assigned_and_evaluated +6394,59211,20.142,0.99853516,Nucleotide-diphospho-sugar transferases,interpro,38317,Pentatricopeptide repeat,0.9902344,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9994982078853046,0.9310185281801651,0.011076650420912717,1.0,84.0523527241053,17.0,17.0,244.34836065573774,1.3495568203358695e-40,Beta-strand hydrophobe near acidic motif,True,assigned_and_evaluated +6395,29104,16.325697,0.7426758,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.7426758,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,1.0,12.0,35.74400479616307,0.04609857825921461,Transmembrane helix packing motifs,True,assigned_too_few_test_positives +6396,82029,26.379013,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Transporter TM helix hotspots,True,assigned_too_few_test_positives +6397,85364,19.053324,0.83984375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.83984375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,SBP C-terminal aromatic hotspot,True,assigned_too_few_test_positives +6398,88058,16.642017,0.60253906,Signal,keyword,88058,Signal,0.60253906,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6122421930102768,0.1060519942862645,0.09127159946832078,,1.1619385975927135,3.0,20.0,1.0807432024169183,0.8334769282943363,Polar low-complexity disordered stretches,True,assigned_and_evaluated +6399,45290,15.631475,0.8613281,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.8613281,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9103935280405868,0.08518759665906496,0.0057598582188746125,,14.789877358423816,0.0,14.0,0.0,1.0,Domain-boundary beta-strand signal,True,assigned_and_evaluated +6400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and loops,False,no_term_above_threshold +6401,37312,16.44903,1.0,"DNA-binding HTH domain, TetR-type",interpro,37312,"DNA-binding HTH domain, TetR-type",1.0,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,4.0,20.0,172.8144927536232,1.579594877930152e-08,S/T-rich regulatory IDR motifs,True,assigned_too_few_test_positives +6402,87276,42.5469,0.69384766,Cell membrane,keyword,88161,Transmembrane helix,0.6772461,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8095265994844152,0.59404434487098,0.11120957022596367,0.6613545816733067,5.341665682764151,16.0,18.0,7.293757837110438,6.233534051251394e-13,Alpha-helical transmembrane segments,True,assigned_and_evaluated +6403,87857,24.682446,0.69189453,Nucleus,keyword,87857,Nucleus,0.69189453,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7022902170561344,0.17851852794961875,0.06247230837394772,0.0851063829787234,2.8575625360446066,5.0,20.0,1.5147611788617885,0.3541981415107029,Basic disordered NLS/NA-binding patches,True,assigned_and_evaluated +6404,46082,16.480484,0.95458984,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.95458984,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9965079365079366,0.7030303030303029,0.0031014621178555605,0.5714285714285714,226.67705627705624,15.0,15.0,150.93924050632913,7.117153535323136e-33,Phosphoinositide-driven membrane recruitment,True,assigned_and_evaluated +6405,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine residue detector,False,no_term_above_threshold +6406,81858,18.967854,0.9589844,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6977539,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,2.0,18.0,29.055068226120856,0.0037144812267210243,TM helix-loop junction motif,True,assigned_too_few_test_positives +6407,82029,17.457216,0.91796875,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8574219,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane interfacial segments,True,assigned_too_few_test_positives +6408,87276,20.24863,0.6074219,Cell membrane,keyword,87276,Cell membrane,0.6074219,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6806661688242046,0.26680636897370075,0.11120957022596367,0.11155378486055777,2.3991313736001696,4.0,14.0,2.344422161928355,0.13184448366197937,Small multipass core TM helices,True,assigned_and_evaluated +6409,85656,16.911715,0.82470703,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.8222656,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9857142857142857,0.14154420742656038,0.0031014621178555605,,45.63789659453525,0.0,18.0,0.0,1.0,Acidic helix-capping loop motif,True,assigned_and_evaluated +6410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long N-terminal low-complexity IDRs,False,no_term_above_threshold +6411,87697,16.76477,0.6870117,Knottin,keyword,87697,Knottin,0.6870117,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7022207579015515,0.046573704792336676,0.017279574656623838,,2.6953038901616377,0.0,19.0,0.0,1.0,Broad PPI region activation,True,assigned_and_evaluated +6412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helix-0 hinge module,False,no_term_above_threshold +6413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic amphipathic interface patches,False,no_term_above_threshold +6414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Retroviral capsid helical assembly,False,no_term_above_threshold +6415,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme active-site gating loops,False,no_term_above_threshold +6416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral capsid beta-sandwich core,False,no_term_above_threshold +6417,87852,19.845768,0.9316406,Nucleosome core,keyword,24789,nucleosome,0.8881836,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,16.0,0.0,1.0,Arginine-rich RS-like IDRs,True,assigned_too_few_test_positives +6418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-protein linker/hinge regions,False,no_term_above_threshold +6419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved NTP phosphate-binding motifs,False,no_term_above_threshold +6420,37097,17.02136,0.7055664,Cro/C1-type helix-turn-helix domain,interpro,37097,Cro/C1-type helix-turn-helix domain,0.7055664,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,16.0,0.0,1.0,Filamentous coiled-coil assembly,True,assigned_too_few_test_positives +6421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-cofactor substrate-binding interfaces,False,no_term_above_threshold +6422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved β-strand/loop functional hotspots,False,no_term_above_threshold +6423,85664,21.666164,0.9658203,Glycogen Phosphorylase B;,gene3d,87525,Glycosyltransferase,0.8125,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase acceptor-gating loop,True,assigned_too_few_test_positives +6424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cleavable N-terminal signal peptide,False,no_term_above_threshold +6425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical assembly-interface signal,False,no_term_above_threshold +6426,36535,20.668411,0.97021484,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9555664,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9980418335558523,0.9185185185185185,0.004430660168365086,0.9,207.30962962962965,19.0,19.0,89.79066265060241,3.7420828801112705e-37,Kinase activation segment C-terminus motif,True,assigned_and_evaluated +6427,59229,26.102474,0.9765625,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9536133,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9420711533221751,0.7458774334714707,0.0101905183872397,0.7391304347826086,73.19327684109172,16.0,16.0,106.27629233511585,1.339381655082284e-32,Motif II SAM-binding strand,True,assigned_and_evaluated +6428,36091,21.447704,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9995117,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,16.0,16.0,377.3481012658228,2.771510391945679e-41,GNAT catalytic β–loop–β hairpin,True,assigned_too_few_test_positives +6429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domains and TM helices,False,no_term_above_threshold +6430,49236,18.857498,0.7182617,C-type lectin fold,interpro,49236,C-type lectin fold,0.7182617,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.697335701598579,0.14132919805050953,0.002215330084182543,0.2,63.79600000000001,0.0,15.0,0.0,1.0,VOC/cupin metalloenzyme signature,True,assigned_and_evaluated +6431,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P450 F-helix roof activation,False,no_term_above_threshold +6432,36354,16.531836,0.9609375,RNA recognition motif domain,interpro,46932,Zinc finger C2H2-type,0.90771484,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,15.0,0.0,1.0,REC beta2-alpha2 docking loop,True,assigned_too_few_test_positives +6433,59229,25.768538,0.70751953,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.70751953,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.605367638472617,0.17774744503183562,0.0101905183872397,0.17391304347826086,17.442434062471868,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM-dependent RNA methyltransferase core,True,assigned_and_evaluated +6434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helix-loop phosphate-binding patch,False,no_term_above_threshold +6435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal capping helical hairpin,False,no_term_above_threshold +6436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,c-type heme ligation context,False,no_term_above_threshold +6437,50338,15.665747,0.90283203,"GPCR, rhodopsin-like, 7TM",interpro,28225,metalloendopeptidase activity,0.8618164,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,HExxH metalloprotease active site,True,assigned_too_few_test_positives +6438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Processed extracytoplasmic domains,False,no_term_above_threshold +6439,24907,16.949339,0.6850586,extracellular space,go_cc,88058,Signal,0.61816406,241,go,GO:0005615,go_cc:go:GO:0005615,18.0,2257.0,0.7008833308520669,0.07943549189345682,0.007975188303057155,,9.96032806686289,8.0,16.0,18.619925046845722,5.751842338087e-09,N-terminal ectodomain recognition module,True,assigned_and_evaluated +6440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta edge motif,False,no_term_above_threshold +6441,47529,20.806839,0.9526367,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9526367,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9605923694779116,0.14846540920870357,0.007089056269384138,,20.94290178650275,1.0,16.0,4.833090142671855,0.29742221945743563,Beta-strand core recognizer,True,assigned_and_evaluated +6442,50338,15.95074,0.9213867,"GPCR, rhodopsin-like, 7TM",interpro,82029,MFS general substrate transporter like domains,0.8359375,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix capping segments,True,assigned_too_few_test_positives +6443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic STPG-rich helical scaffolds,False,no_term_above_threshold +6444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal disordered segments,False,no_term_above_threshold +6445,15821,17.918812,0.6894531,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6894531,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,14.0,0.0,1.0,Broad uL10 core-helix activation,True,assigned_too_few_test_positives +6446,85672,22.497156,0.6191406,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6166992,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6295087298013907,0.19444119310922592,0.01595037660611431,0.2222222222222222,12.190382579097859,16.0,16.0,40.01409395973155,6.696154575406941e-26,ATP-dependent phosphotransfer kinase core,True,assigned_and_evaluated +6447,64058,16.348227,0.8173828,NAD(P)-binding domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.71191406,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9282848226227629,0.07627533282770887,0.006202924235711121,,12.296673299438496,1.0,14.0,8.142720568150777,0.18685692288870961,Hydrophobic REC output face,True,assigned_and_evaluated +6448,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular N-terminal beta core,False,no_term_above_threshold +6449,36272,16.550951,0.95751953,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.72216797,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,11.0,0.0,1.0,Kinase C-lobe helical cap,True,assigned_too_few_test_positives +6450,59224,25.239614,0.99316406,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.99316406,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,16.0,16.0,137.37557603686636,2.308526036036146e-34,AB-hydrolase oxyanion-hole motif,True,assigned_and_evaluated +6451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GIY-YIG catalytic core,False,no_term_above_threshold +6452,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chlorophyll/heme NGRAAM/WxWG motifs,False,no_term_above_threshold +6453,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH mid-chain catalytic-domain motif,False,no_term_above_threshold +6454,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coils and four-helix bundles,False,no_term_above_threshold +6455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TRP channel S1–S2 membrane-entry,False,no_term_above_threshold +6456,87413,23.659058,0.6035156,Disulfide bond,keyword,87413,Disulfide bond,0.6035156,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5955007513480067,0.15243244675810735,0.0717766947275144,0.07407407407407407,2.1237039032904215,17.0,20.0,10.053134298750248,1.1850580174109663e-15,Disulfide peptides and hydrophobic motifs,True,assigned_and_evaluated +6457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/PAC C-terminal scaffold,False,no_term_above_threshold +6458,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged interface patches,False,no_term_above_threshold +6459,50763,15.82496,0.8901367,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.8120117,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,15.0,0.0,1.0,HExxH metal-binding helix,True,assigned_too_few_test_positives +6460,36886,19.692657,0.8930664,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.8930664,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9285793686082703,0.17923545418422468,0.003544528134692069,,50.56680251172439,0.0,17.0,0.0,1.0,C-terminal CDC25-homology Ras-GEF domain,True,assigned_and_evaluated +6461,29104,23.02853,0.82714844,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.82714844,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,8.0,11.0,311.9476782210595,2.971522223504735e-19,Hydrophobic transmembrane helix bundles,True,assigned_too_few_test_positives +6462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bimodal disordered and catalytic activation,False,no_term_above_threshold +6463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural scaffold segment,False,no_term_above_threshold +6464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal β-barrels aaRS β-sheets,False,no_term_above_threshold +6465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal charged micro-motifs,False,no_term_above_threshold +6466,37341,17.08963,0.9091797,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8720703,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9904085700049825,0.7141232035907258,0.011962782454585734,0.7777777777777778,59.6954100186766,9.0,20.0,65.43768292682927,1.1484608259444871e-14,C-terminal scaffold interaction surfaces,True,assigned_and_evaluated +6467,85649,20.714369,0.9536133,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.9536133,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9360573741777276,0.5654077292505806,0.0101905183872397,0.7391304347826086,55.48370630080697,2.0,15.0,14.748546691403833,0.01354175700917994,Hydrophobic nucleotide-binding pocket residues,True,assigned_and_evaluated +6468,80982,18.018366,0.8510742,ACP-like,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6948242,44,gene3d,1.10.1200.10,gene3d:gene3d:1.10.1200.10,12.0,2257.0,0.8539161098737936,0.06288649899652698,0.005316792202038104,,11.827902352930117,0.0,17.0,0.0,1.0,Oxidoreductase C-terminal substrate loop,True,assigned_and_evaluated +6469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich tails and helices,False,no_term_above_threshold +6470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed recognition segments,False,no_term_above_threshold +6471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket scaffolds,False,no_term_above_threshold +6472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic N-terminal accessory segments,False,no_term_above_threshold +6473,85649,37.246475,0.8491211,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.84765625,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8655171071581488,0.6268539286237154,0.0101905183872397,0.6521739130434783,61.513448561031545,17.0,17.0,110.61410018552876,7.110790058883305e-35,N-terminal regulatory helix,True,assigned_and_evaluated +6474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PsbP/MOG1 core domain,False,no_term_above_threshold +6475,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal activation boundary segment,False,no_term_above_threshold +6476,36776,16.201778,0.9814453,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.8798828,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9915593069746779,0.1495414863549875,0.002658396101019052,,56.252522450534464,1.0,15.0,21.25525846702317,0.07603514768294786,HTH family recognition helix,True,assigned_and_evaluated +6477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central helical assembly scaffolds,False,no_term_above_threshold +6478,64058,33.50562,0.9472656,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9345703,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9858926183045665,0.2942002562210057,0.006202924235711121,0.2857142857142857,47.429284163629276,12.0,19.0,71.99879239207003,2.284698542515769e-20,Rossmann-like glycine-rich loop,True,assigned_and_evaluated +6479,45290,16.124746,0.86376953,Protein kinase-like domain superfamily,interpro,87697,Knottin,0.82910156,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9640237213766625,0.15122523148113823,0.0057598582188746125,,26.255026727148383,1.0,19.0,3.864467202488981,0.36106893902994075,Acidic hydrophobic beta-strand motif,True,assigned_and_evaluated +6480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclase catalytic beta-alpha segment,False,no_term_above_threshold +6481,37071,17.286377,0.8769531,Homeodomain,interpro,88150,Transcription regulation,0.6152344,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,16.0,16.0,206.30103806228374,3.8109720609411366e-37,Disordered transactivation tails in TFs,True,assigned_too_few_test_positives +6482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming transmembrane helices,False,no_term_above_threshold +6483,45714,20.568977,0.9868164,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,87149,Amphibian defense peptide,0.71435547,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,16.0,0.0,1.0,Amphipathic oligomerization helices,True,assigned_too_few_test_positives +6484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prion-like low-complexity IDRs,False,no_term_above_threshold +6485,58239,24.831043,0.7114258,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7114258,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8048150654036986,0.31478556151164394,0.017722640673460344,0.275,17.76177530829451,4.0,17.0,8.435640762618938,0.0018813444914944797,TIR/SEFIR catalytic/signaling helix,True,assigned_and_evaluated +6486,85762,30.152617,0.8720703,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.87109375,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,15.0,16.0,192.74030172413794,1.0564145132955471e-33,Upstream NAD-binding Rossmann segment,True,assigned_too_few_test_positives +6487,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-cap boundary segments,False,no_term_above_threshold +6488,47529,16.30248,0.7050781,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7050781,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7373103525211958,0.14575858947985096,0.007089056269384138,,20.561071028501477,1.0,12.0,6.44412019022914,0.23031300626860388,Extended beta-loop interaction surfaces,True,assigned_and_evaluated +6489,87276,37.220734,0.6699219,Cell membrane,keyword,88161,Transmembrane helix,0.6503906,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.777332345592704,0.45767159031238136,0.11120957022596367,0.5976095617529881,4.115397527231254,14.0,16.0,7.179792870905588,3.1869533622060737e-11,TM1 signal-anchor helix,True,assigned_and_evaluated +6490,88009,16.905775,0.6098633,Repeat,keyword,88009,Repeat,0.6098633,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7748957034481956,0.28847709961212387,0.07266282676118742,0.29878048780487804,3.970078133076607,7.0,17.0,3.6505313798381804,0.00280585543030459,Folded globular domain detector,True,assigned_and_evaluated +6491,29034,18.577166,0.6694336,GTP binding,go_mf,29034,GTP binding,0.6694336,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.5959767545820295,0.07288992207024994,0.008861320336730172,,8.225627705627707,8.0,8.0,129.6108695652174,2.888813623748624e-17,MnmE/TrmE folate-binding helix,True,assigned_and_evaluated +6492,59218,16.169962,0.7294922,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.7294922,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,13.0,15.0,482.91152647975076,4.750253488391375e-34,Metal/phosphate coordination and transport,True,assigned_too_few_test_positives +6493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal pre-domain leaders,False,no_term_above_threshold +6494,61392,17.136265,0.6381836,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.6381836,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.4955555555555556,0.0031014621178555605,0.0031014621178555605,,1.0,0.0,16.0,0.0,1.0,Extracellular repeat loop adhesins,True,assigned_and_evaluated +6495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP enzyme helix N-cap loops,False,no_term_above_threshold +6496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix–coil junction loops,False,no_term_above_threshold +6497,36272,16.317188,0.95751953,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.95751953,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,13.0,0.0,1.0,FNR-type FAD-binding subdomain,True,assigned_too_few_test_positives +6498,28882,16.388935,0.796875,neuropeptide hormone activity,go_mf,8705,neuropeptide signaling pathway,0.60009766,56,go,GO:0005184,go_mf:go:GO:0005184,,,,,,,,0.0,18.0,0.0,1.0,Acidic low-complexity IDRs,True,assigned_too_few_test_positives +6499,59229,26.27683,0.68408203,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.68408203,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.6178428243353704,0.0496687552518317,0.0101905183872397,0.043478260869565216,4.874016547973223,10.0,10.0,106.27629233511585,1.3285914921647095e-20,RsmH/METTL15 rRNA m4C methyltransferases,True,assigned_and_evaluated +6500,38317,21.085842,0.92822266,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.92822266,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7684761904761904,0.031397181818973004,0.0031014621178555605,,10.123348480774581,0.0,13.0,0.0,1.0,Disordered kinase regulatory tails,True,assigned_and_evaluated +6501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-access exosite segment,False,no_term_above_threshold +6502,38873,19.404993,0.97314453,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8540039,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9976021314387211,0.6088888888888888,0.002215330084182543,0.6,274.8524444444444,11.0,11.0,171.32471264367817,6.880872708632078e-25,ABC transporter NBD switch loops,True,assigned_and_evaluated +6503,38317,17.920525,0.97558594,Pentatricopeptide repeat,interpro,88009,Repeat,0.72265625,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9812380952380952,0.21622326481349036,0.0031014621178555605,0.14285714285714285,69.71655838343538,2.0,17.0,45.25313092979127,0.0015672356275132431,Tandem repeat consensus signature,True,assigned_and_evaluated +6504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed termini and loops,False,no_term_above_threshold +6505,59224,18.74972,0.6665039,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.6665039,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7797777777777778,0.33677893350024496,0.0031014621178555605,0.2857142857142857,108.58715041572184,13.0,13.0,137.37557603686636,4.588142736190252e-28,Glycine loop peaks; serine silent,True,assigned_and_evaluated +6506,64016,27.639997,0.7128906,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.7084961,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.638095238095238,0.18588879947193765,0.0031014621178555605,0.14285714285714285,59.93586005830904,12.0,16.0,166.2295539033457,3.032460172604699e-25,C-terminal interaction surfaces,True,assigned_and_evaluated +6507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HTH/winged-helix DNA-binding motifs,False,no_term_above_threshold +6508,45288,17.097988,0.8178711,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.8178711,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,18.0,18.0,462.17829457364337,1.3033289657798122e-47,Two-component REC domain activation,True,assigned_too_few_test_positives +6509,85656,17.53055,0.93359375,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.86572266,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9642222222222222,0.0576521584067461,0.0031014621178555605,,18.58870307486085,3.0,17.0,24.932115974351827,0.00040037959353151573,Secondary structure boundary caps,True,assigned_and_evaluated +6510,64016,36.97121,0.9916992,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.984375,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9986031746031746,0.5503924646781789,0.0031014621178555605,1.0,177.4622561112357,12.0,16.0,166.2295539033457,3.032460172604699e-25,Sheet-edge beta strand,True,assigned_and_evaluated +6511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane hairpin module,False,no_term_above_threshold +6512,64058,16.119053,0.8027344,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.8027344,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8847684860836891,0.036427646688214965,0.006202924235711121,,5.872657041092941,0.0,17.0,0.0,1.0,Helix C-cap glycine hinge,True,assigned_and_evaluated +6513,61392,24.04072,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9997460317460317,0.9325396825396823,0.0031014621178555605,1.0,300.67743764172326,19.0,19.0,167.4747191011236,3.9106228067767924e-42,Leucine-rich repeat domain signal,True,assigned_and_evaluated +6514,63831,31.462994,0.9975586,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9975586,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9996297941655561,0.8833333333333333,0.002658396101019052,1.0,332.2805555555555,14.0,19.0,180.787091184752,1.0185766884655946e-29,Skp1-binding F-box helix,True,assigned_and_evaluated +6515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic mature-domain scaffold activation,False,no_term_above_threshold +6516,39971,25.277966,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98583984,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,17.0,18.0,625.6524691358024,1.2465223298043957e-46,Metallo-hydrolase active-site rim loops,True,assigned_too_few_test_positives +6517,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interaction surfaces and catalytic hotspots,False,no_term_above_threshold +6518,36091,20.156237,0.95947266,GNAT domain,interpro,85712,3.40.630.30,0.94873047,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,CBS β-to-α transition motifs,True,assigned_too_few_test_positives +6519,64596,28.466534,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,59218,Metallo-dependent phosphatase-like,0.9667969,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,15.0,15.0,614.6494845360825,5.269182503336926e-42,MBL motif 1 metal site,True,assigned_too_few_test_positives +6520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic low-complexity segments,False,no_term_above_threshold +6521,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase palm NTP-binding region,False,no_term_above_threshold +6522,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal AS hydrolase subregion,False,no_term_above_threshold +6523,59229,40.082077,0.99072266,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.99072266,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8665875209217235,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,19.0,19.0,106.27629233511585,1.6359638213673626e-38,SAM-dependent methyltransferase motif I,True,assigned_and_evaluated +6524,37690,17.058926,0.7265625,Ankyrin repeat,interpro,37690,Ankyrin repeat,0.7265625,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.8213333333333334,0.02270018807371412,0.0031014621178555605,,7.319189211767538,0.0,17.0,0.0,1.0,Aromatic helices near active sites,True,assigned_and_evaluated +6525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic oligomerization helices,False,no_term_above_threshold +6526,87413,25.161987,0.6191406,Disulfide bond,keyword,88058,Signal,0.60058594,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6218701199210347,0.13962538056875817,0.0717766947275144,,1.9452745922449828,6.0,17.0,4.174311819550276,0.0034529279210178767,C-terminal IDLSxG calcium-cap motif,True,assigned_and_evaluated +6527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass transporter TM core,False,no_term_above_threshold +6528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic acidic polysaccharide-binding surfaces,False,no_term_above_threshold +6529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SRAP-domain N-terminal peak,False,no_term_above_threshold +6530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic lipid-linked transferases,False,no_term_above_threshold +6531,88164,18.936125,0.8598633,Transposition,keyword,88164,Transposition,0.8598633,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8946269982238011,0.3537763993501698,0.002215330084182543,0.6,159.69466666666665,1.0,18.0,40.39363143631436,0.04099858094536486,Internal nucleic-acid-binding regions,True,assigned_and_evaluated +6532,37020,17.387728,0.9975586,"Glycosyl transferase, family 1",interpro,85682,NAD(P)-binding Rossmann-like Domain,0.76123047,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,12.0,0.0,1.0,SDR C-terminal YxTG-GG motif,True,assigned_too_few_test_positives +6533,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal pocket/interface regions,False,no_term_above_threshold +6534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral jelly-roll GxRWS motif,False,no_term_above_threshold +6535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GSP[Y/W/F]xIGS carbohydrate-binding motif,False,no_term_above_threshold +6536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DDR scaffold IDR activation,False,no_term_above_threshold +6537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich anion-binding loops,False,no_term_above_threshold +6538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding lid,False,no_term_above_threshold +6539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS sensor domain cores,False,no_term_above_threshold +6540,81858,19.15022,0.9633789,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.68310547,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Transmembrane helices and signal peptides,True,assigned_too_few_test_positives +6541,49116,24.540627,0.97558594,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97558594,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9995559502664298,0.71,0.002215330084182543,1.0,320.494,19.0,19.0,87.03795620437957,6.605101239071875e-37,HEAT/ARM helix register,True,assigned_and_evaluated +6542,38878,17.089834,0.96435547,Immunoglobulin subtype,interpro,63951,Immunoglobulin-like domain superfamily,0.9003906,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,0.0,11.0,0.0,1.0,Acidic PEST-like IDRs,True,assigned_too_few_test_positives +6543,55053,17.27917,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,11.0,11.0,552.0462962962963,1.580946100244615e-30,NRPS condensation and acyltransferase cores,True,assigned_too_few_test_positives +6544,87162,16.38948,0.67285156,Antimicrobial,keyword,87162,Antimicrobial,0.67285156,669,keywords,Antimicrobial,keyword:keywords:Antimicrobial,56.0,2257.0,0.683642175634452,0.042054588441172235,0.024811696942844484,,1.6949501091379595,0.0,16.0,0.0,1.0,TESPA1/ITPRID cassette hotspot,True,assigned_and_evaluated +6545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical regions,False,no_term_above_threshold +6546,85649,37.294376,0.86865234,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.86328125,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6025261764820367,0.17749648825913972,0.0101905183872397,0.13043478260869565,17.41780756525558,12.0,12.0,110.61410018552876,7.925049903530729e-25,C-terminal SAM transferase hotspot,True,assigned_and_evaluated +6547,36010,16.71615,0.98779297,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.96728516,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,2.0,17.0,59.950729009552546,0.0009047316924136937,Gly-rich oxyanion-hole loop,True,assigned_too_few_test_positives +6548,36010,17.270517,0.9921875,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9550781,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,3.0,19.0,80.46018893387314,1.3074909241428665e-05,Alpha/beta-hydrolase core activation,True,assigned_too_few_test_positives +6549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal and linker IDRs,False,no_term_above_threshold +6550,52236,19.952448,0.9658203,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9355469,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,7.0,18.0,86.83874323761964,2.237375140136008e-12,"TPR/Sel1 periodic peaks, ASK motif",True,assigned_too_few_test_positives +6551,36409,17.346266,0.6816406,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.6816406,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,14.0,0.0,1.0,Gly/Asp-rich extracellular beta-strand repeats,True,assigned_too_few_test_positives +6552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pilin acidic loop/PPxY motifs,False,no_term_above_threshold +6553,88277,19.694933,0.7949219,rRNA-binding,keyword,88022,Ribosomal protein,0.74609375,96,keywords,rRNA-binding,keyword:keywords:rRNA-binding,19.0,2257.0,0.5989487794553408,0.10106954914979073,0.008418254319893664,0.05263157894736842,12.005998549004088,7.0,10.0,128.02055214723924,3.723784603416463e-14,Ribosomal uL3 core activation,True,assigned_and_evaluated +6554,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic TM1-TM2 sensor modules,False,no_term_above_threshold +6555,64148,24.561533,0.7626953,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7495117,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8522882272705894,0.29043705431795286,0.008418254319893664,0.5263157894736842,34.50086482082209,3.0,18.0,14.831094527363183,0.0017866662505316036,Localized Leu-rich helical motif,True,assigned_and_evaluated +6556,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored catalytic transmembrane helix,False,no_term_above_threshold +6557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature-domain catalytic motifs,False,no_term_above_threshold +6558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane hydrophobic segments,False,no_term_above_threshold +6559,64475,18.193182,0.9951172,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.96240234,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9976347182229535,0.5216762346436079,0.0057598582188746125,1.0,90.57102012235562,0.0,8.0,0.0,1.0,Sigma70 region-2 helical interface,True,assigned_and_evaluated +6560,37007,23.612593,0.9995117,Metallo-beta-lactamase,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9863281,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,15.0,16.0,776.3151041666666,7.531013737783229e-43,MBL N-terminal beta-strand motif,True,assigned_too_few_test_positives +6561,80926,15.824169,0.65283203,Homeodomain-like,gene3d,80926,Homeodomain-like,0.65283203,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.6400143973673386,0.03543286456738723,0.0057598582188746125,,6.151690409891767,0.0,17.0,0.0,1.0,Structured regulatory and catalytic cores,True,assigned_and_evaluated +6562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA primase PrimPol signature,False,no_term_above_threshold +6563,64599,18.13579,0.8671875,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.8671875,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,0.0,13.0,0.0,1.0,PDZ carboxylate-binding groove,True,assigned_too_few_test_positives +6564,49116,21.960323,0.8979492,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8979492,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9976909413854351,0.4453588516746412,0.002215330084182543,0.6,201.03498564593303,14.0,20.0,60.926569343065694,6.288806491154213e-23,Large noncatalytic scaffold regions,True,assigned_and_evaluated +6565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic disordered low-complexity tails,False,no_term_above_threshold +6566,87149,22.435312,0.7128906,Amphibian defense peptide,keyword,88058,Signal,0.60839844,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7194850349291804,0.03254602381399889,0.012405848471422242,,2.623441991006982,0.0,20.0,0.0,1.0,C-terminal transmembrane anchor,True,assigned_and_evaluated +6567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar helix-capping/linker motif,False,no_term_above_threshold +6568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged cytosolic membrane tails/loops,False,no_term_above_threshold +6569,87786,20.05149,0.6557617,Mitochondrion inner membrane,keyword,87786,Mitochondrion inner membrane,0.6557617,163,keywords,Mitochondrion inner membrane,keyword:keywords:Mitochondrion inner membrane,15.0,2257.0,0.6889681831697888,0.08285142038377585,0.00664599025254763,,12.466377053745473,3.0,19.0,13.80328754437413,0.0022040310814984646,Organelle-targeting amphipathic motifs,True,assigned_and_evaluated +6570,87239,16.760914,0.77197266,CF(1),keyword,87239,CF(1),0.77197266,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9982565936522128,0.6827329249697671,0.008861320336730172,1.0,77.04641058283822,0.0,11.0,0.0,1.0,Charged coiled-coil linker scaffolds,True,assigned_and_evaluated +6571,85672,18.74363,0.7290039,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7182617,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6931437290509781,0.0912591895233156,0.01595037660611431,0.05555555555555555,5.721444187614537,1.0,11.0,3.6376449054301405,0.3822159766529688,PGM/SecA aromatic-proline motif,True,assigned_and_evaluated +6572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/His metal/phosphate-binding micro-motifs,False,no_term_above_threshold +6573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T-rich regulatory IDRs,False,no_term_above_threshold +6574,47717,17.39759,0.9873047,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6254883,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,11.0,248.62802335279397,1.1046647748237842e-23,Helicase C-lobe motif VI helix,True,assigned_too_few_test_positives +6575,36010,17.100748,0.9980469,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9765625,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,17.0,19.0,455.9410706252812,7.976975571869202e-44,Alpha/beta-hydrolase cap helix,True,assigned_too_few_test_positives +6576,49230,15.700878,0.9584961,Acyl-CoA N-acyltransferase,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.828125,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,15.0,16.0,263.6541863207547,9.583108103019209e-36,Hydrophobic pocket-lining residues,True,assigned_too_few_test_positives +6577,87276,42.144566,0.69140625,Cell membrane,keyword,88161,Transmembrane helix,0.66845703,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7852071276211207,0.5665553288748089,0.11120957022596367,0.6095617529880478,5.094483574782644,9.0,16.0,4.615581131296449,5.556094384754105e-05,Alpha-helical transmembrane segments,True,assigned_and_evaluated +6578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered linkers and tails,False,no_term_above_threshold +6579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine detector with zinc-finger bias,False,no_term_above_threshold +6580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered amphipathic helices,False,no_term_above_threshold +6581,38654,20.168882,0.99072266,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.97802734,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,Exposed beta-rich surface loops,True,assigned_too_few_test_positives +6582,64599,17.911129,0.9765625,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.9765625,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,16.0,19.0,557.8573099415205,2.0289762034914882e-42,Accessory regions outside cores,True,assigned_too_few_test_positives +6583,85364,27.689543,0.9946289,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9946289,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,20.0,271.00454545454545,2.4396380434571384e-42,Ligand binding cleft hinge,True,assigned_too_few_test_positives +6584,85649,17.917784,0.6230469,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6220703,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.5545327157370284,0.05828071002077014,0.0101905183872397,0.043478260869565216,5.719111413777313,7.0,13.0,59.56143856143856,1.6769361484671054e-11,RNA-modifying enzyme catalytic cores,True,assigned_and_evaluated +6585,59229,34.812237,0.7993164,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7993164,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7772371647658712,0.4885190355610881,0.0101905183872397,0.4782608695652174,47.93858535919025,15.0,15.0,106.27629233511585,1.2978692612531535e-30,Class I SAM MTase core,True,assigned_and_evaluated +6586,38873,17.078558,0.8105469,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7792969,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7904085257548846,0.09309392424146523,0.002215330084182543,,42.022597402597405,2.0,16.0,21.41558908045977,0.006659745971125565,Helicase nucleic-acid binding surface,True,assigned_and_evaluated +6587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic alpha-helical signal,False,no_term_above_threshold +6588,45290,29.061329,0.97314453,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97314453,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9973947621006445,0.9343128781331027,0.0057598582188746125,0.9230769230769231,162.2110896881856,19.0,19.0,73.42487684729065,1.537287712313484e-35,Kinase glycine beta-alpha junction,True,assigned_and_evaluated +6589,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM helix exit,False,no_term_above_threshold +6590,49121,19.888113,0.9350586,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.9350586,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,17.0,17.0,977.3934426229509,1.5932300158717148e-50,HTH recognition helix,True,assigned_too_few_test_positives +6591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping linkers,False,no_term_above_threshold +6592,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated alpha-helical scaffolds,False,no_term_above_threshold +6593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pocket-lining segments,False,no_term_above_threshold +6594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered pre-PH linker,False,no_term_above_threshold +6595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity IDRs,False,no_term_above_threshold +6596,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hotspots near Fe-S motifs,False,no_term_above_threshold +6597,37640,16.396187,0.9746094,EF-hand domain,interpro,46081,EF-hand domain pair,0.96484375,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,5.0,16.0,93.62594221105527,3.4160406133377107e-09,Generic amphipathic packing helix,True,assigned_too_few_test_positives +6598,38654,23.332787,0.94384766,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9345703,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,12.0,0.0,1.0,Catalytic core region activation,True,assigned_too_few_test_positives +6599,88178,15.693209,0.6376953,Ubiquinone,keyword,6543,NADH:ubiquinone reductase (H+-translocating),0.6333008,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane helix boundary loops,True,assigned_too_few_test_positives +6600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered terminal tails,False,no_term_above_threshold +6601,64146,16.942469,0.76171875,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.76171875,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.7443178998560865,0.018440066170291414,0.007975188303057155,,2.312179408130429,5.0,16.0,20.887401905829595,5.355525936134953e-06,Non-catalytic amphipathic alpha-helices,True,assigned_and_evaluated +6602,84152,26.615328,0.9536133,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9536133,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,15.0,15.0,562.4622641509434,2.0575595524537636e-41,N-terminal metal-phosphate coordination module,True,assigned_too_few_test_positives +6603,50806,22.808641,0.90966797,"Homeobox, conserved site",interpro,37071,Homeodomain,0.8261719,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,C-terminal interaction/catalytic domains,True,assigned_too_few_test_positives +6604,87276,42.03022,0.6904297,Cell membrane,keyword,88161,Transmembrane helix,0.6660156,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.711395693397894,0.432528690676952,0.11120957022596367,0.4541832669322709,3.889311772342154,17.0,18.0,7.749617701929841,1.050934808049714e-14,Selective transmembrane helix activation,True,assigned_and_evaluated +6605,8138,16.468628,0.6801758,translation,go_bp,88022,Ribosomal protein,0.65283203,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.8021264418420359,0.10778881817876268,0.018165706690296855,,5.9336429909626185,8.0,12.0,68.76701268742791,8.105469772124857e-14,N-terminal basic RNA-binding patches,True,assigned_and_evaluated +6606,36876,16.728758,0.9995117,Cytochrome P450,interpro,64154,Cytochrome P450 superfamily,0.9995117,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,16.0,16.0,389.6797385620915,1.6482263221307779e-41,P450 membrane-proximal A-helix,True,assigned_and_evaluated +6607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminal targeting/regulatory segments,False,no_term_above_threshold +6608,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GEF catalytic helical bundles,False,no_term_above_threshold +6609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich extracellular low-complexity segments,False,no_term_above_threshold +6610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Activated disordered flanking regions,False,no_term_above_threshold +6611,37640,25.456398,0.9970703,EF-hand domain,interpro,46081,EF-hand domain pair,0.99121094,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,17.0,19.0,268.0658555937583,5.687667946748188e-40,EF-hand calcium regulatory helices,True,assigned_too_few_test_positives +6612,88009,17.148693,0.60839844,Repeat,keyword,88009,Repeat,0.60839844,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.664087900434666,0.1819907406902209,0.07266282676118742,0.07317073170731707,2.504592083767247,7.0,18.0,3.447724080958282,0.004126155298224271,Disordered low-complexity repeats,True,assigned_and_evaluated +6613,37894,22.239275,0.9370117,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8769531,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Cofactor-binding beta-loop-beta motif,True,assigned_too_few_test_positives +6614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-propeller α-solenoid arms,False,no_term_above_threshold +6615,81858,15.822229,0.9848633,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.64746094,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,16.0,16.0,261.4956140350877,9.006051383641506e-39,GPCR 7TM hydrophobic core,True,assigned_too_few_test_positives +6616,48241,16.23823,0.7963867,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.7963867,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,0.0,18.0,0.0,1.0,HATPase_c G1/ATP-lid motif,True,assigned_too_few_test_positives +6617,36409,15.871905,0.78759766,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.78759766,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,4.0,20.0,88.9865671641791,2.2562532616880078e-07,RNA-binding low-complexity IDRs,True,assigned_too_few_test_positives +6618,38317,20.726885,0.9946289,Pentatricopeptide repeat,interpro,88009,Repeat,0.6616211,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9900952380952381,0.3391755621728526,0.0031014621178555605,0.42857142857142855,109.35989197487548,10.0,18.0,213.69534050179212,1.2239746070926833e-21,Leucine rich solenoid repeats,True,assigned_and_evaluated +6619,37341,20.344099,0.99072266,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98828125,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.99853014449427,0.7710991418065236,0.011962782454585734,1.0,64.45817640953051,0.0,17.0,0.0,1.0,β-propeller blade start residues,True,assigned_and_evaluated +6620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered helix-edge bias,False,no_term_above_threshold +6621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal entry module detector,False,no_term_above_threshold +6622,46929,18.23059,0.75146484,"Zinc finger, RING/FYVE/PHD-type",interpro,29166,zinc ion binding,0.67578125,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.6813055062166962,0.023836320557632032,0.002215330084182543,,10.7597150997151,2.0,17.0,10.10696728259027,0.02770072805833847,N-terminal Cys/His-rich domains,True,assigned_and_evaluated +6623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich cytosolic linkers,False,no_term_above_threshold +6624,88160,18.65342,0.87597656,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7416992,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,17.0,19.0,258.956821665815,1.0042305581164375e-39,OMP β-barrel strand boundaries,True,assigned_too_few_test_positives +6625,82029,20.853725,0.9980469,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.64208984,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,19.0,158.38220156068402,1.2522467477825838e-33,Transmembrane helix-loop boundary residues,True,assigned_too_few_test_positives +6626,59224,17.189524,0.92041016,Alpha/Beta hydrolase fold,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.89501953,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9664761904761905,0.04819921370937015,0.0031014621178555605,,15.540803620292632,0.0,16.0,0.0,1.0,Catalytic-adjacent helix–strand loops,True,assigned_and_evaluated +6627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sandwich edge-loop activation,False,no_term_above_threshold +6628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate and metal scaffolding residues,False,no_term_above_threshold +6629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader/assembly segment,False,no_term_above_threshold +6630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ntn hydrolase beta-subunit core,False,no_term_above_threshold +6631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic membrane-binding segments,False,no_term_above_threshold +6632,50806,23.854342,0.9555664,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.84033203,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,HTH recognition helix,True,assigned_too_few_test_positives +6633,64146,34.034508,0.9560547,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9560547,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.899483896580815,0.49805770840326297,0.007975188303057155,0.3333333333333333,62.45090265923137,15.0,19.0,52.76817323578003,4.055551391209733e-24,Hydrophobic alpha-helix face,True,assigned_and_evaluated +6634,27735,16.790997,0.6899414,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.6899414,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.6411233320690962,0.10972872546357107,0.011519716437749225,,9.525297437356919,9.0,19.0,21.427561696350132,1.95280644330623e-10,Fungal Q/P-rich low-complexity regulatory IDRs,True,assigned_and_evaluated +6635,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic coiled-coils,False,no_term_above_threshold +6636,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal FAD-anchoring module,False,no_term_above_threshold +6637,45290,22.85938,0.7841797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7841797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7274441245029482,0.3688357278521213,0.0057598582188746125,0.3076923076923077,64.03555675094137,12.0,13.0,67.77680939749906,1.3085124781027786e-21,Kinase C-lobe catalytic scaffold,True,assigned_and_evaluated +6638,37341,22.952606,0.99853516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99560547,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9996844378010298,0.9594958496363275,0.011962782454585734,1.0,80.20674565293301,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 post-W hotspot,True,assigned_and_evaluated +6639,52236,18.078085,0.9902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9785156,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,7.0,18.0,86.83874323761964,2.237375140136008e-12,TPR helix register hotspot,True,assigned_too_few_test_positives +6640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane coupling helix,False,no_term_above_threshold +6641,82029,18.025972,0.7294922,MFS general substrate transporter like domains,gene3d,82029,MFS general substrate transporter like domains,0.7294922,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,11.0,0.0,1.0,N-terminal TM1 signal anchor,True,assigned_too_few_test_positives +6642,63831,20.383476,0.98291016,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.98291016,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9601288316303864,0.03548026692345185,0.002658396101019052,,13.346493741038472,0.0,18.0,0.0,1.0,Cys-adjacent early-helix polar residues,True,assigned_and_evaluated +6643,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-rich active-site lids,False,no_term_above_threshold +6644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro-rich chromatin IDRs,False,no_term_above_threshold +6645,87326,32.204712,0.67578125,Coiled coil,keyword,87326,Coiled coil,0.67578125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6764609851154691,0.29193402387374934,0.03943287549844927,0.3146067415730337,7.403315639135419,16.0,18.0,11.20669157209652,7.469626005007722e-16,Eukaryotic coiled-coil scaffolds,True,assigned_and_evaluated +6646,88058,91.56622,0.8979492,Signal,keyword,88058,Signal,0.8979492,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8767390285581743,0.6433646866192158,0.09127159946832078,0.7815533980582524,7.048903386891117,20.0,20.0,7.204954682779456,1.6966660215964757e-17,Sec-dependent signal peptides,True,assigned_and_evaluated +6647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extramembrane domain,False,no_term_above_threshold +6648,58239,18.666286,0.6020508,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6020508,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.708158547586829,0.2801280702485665,0.017722640673460344,0.4,15.806226363775366,15.0,15.0,35.851473241130485,1.3063198800490947e-23,P-loop NTPase switch regions,True,assigned_and_evaluated +6649,38654,17.195324,0.76416016,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.76416016,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,11.0,0.0,1.0,LPLAT HXXXXD catalytic loop,True,assigned_too_few_test_positives +6650,85364,24.379799,0.79345703,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.79345703,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,1.0,11.0,27.37419651056015,0.05956743938876439,PBP/VFT C-terminal hinge,True,assigned_too_few_test_positives +6651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphotyrosine SH2 signaling hubs,False,no_term_above_threshold +6652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal coupling helices and tails,False,no_term_above_threshold +6653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix terminus capping signal,False,no_term_above_threshold +6654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic interaction appendages,False,no_term_above_threshold +6655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic IDR tails in AAA+,False,no_term_above_threshold +6656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short low-complexity charged runs,False,no_term_above_threshold +6657,59211,31.485044,0.9394531,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9394531,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9978673835125448,0.8300582780390965,0.011076650420912717,0.92,74.93766134136963,10.0,13.0,187.96027742749058,8.458687899864105e-22,Glycosyltransferase catalytic/acceptor pocket,True,assigned_and_evaluated +6658,38873,20.58229,0.80859375,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6586914,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8976021314387213,0.6425483291747311,0.002215330084182543,0.6,290.0463157894737,10.0,10.0,171.32471264367817,1.12424031081604e-22,ABC NBD H-loop hinge,True,assigned_and_evaluated +6659,45289,20.345503,0.6953125,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.6953125,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,0.0,16.0,0.0,1.0,Sensory beta-strand coupling motifs,True,assigned_too_few_test_positives +6660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylase C-terminal lesion module,False,no_term_above_threshold +6661,38878,15.683303,0.99658203,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.85009766,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,11.0,16.0,153.51849250936328,1.4048524024473e-22,IgV N-domain ligand-binding loops,True,assigned_too_few_test_positives +6662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal membrane-proximal amphipathic helix,False,no_term_above_threshold +6663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic C-terminal tails,False,no_term_above_threshold +6664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane bundles,False,no_term_above_threshold +6665,50338,16.796534,0.83154297,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.7734375,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Transporter TM helix gate,True,assigned_too_few_test_positives +6666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-proximal cytosolic IDRs,False,no_term_above_threshold +6667,45290,29.10732,0.96875,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.96875,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9983888660359249,0.9397435897435895,0.0057598582188746125,0.9230769230769231,163.1539447731755,20.0,20.0,73.42487684729065,2.403715910551489e-37,Catalytic-loop HRD+6 hydrophobe,True,assigned_and_evaluated +6668,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-start boundary,False,no_term_above_threshold +6669,66234,22.222506,0.86328125,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.86328125,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,9.0,9.0,236.59126984126982,1.01430172921615e-21,Cys protease active-site neighborhood,True,assigned_too_few_test_positives +6670,83302,17.75379,0.9589844,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9584961,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9790739091718611,0.16750187715505313,0.004873726185201595,,34.36833970354136,3.0,17.0,36.280527383367144,0.00013462503979206215,β-strand edge residue detector,True,assigned_and_evaluated +6671,82716,20.187698,0.86328125,Laminin,gene3d,82716,Laminin,0.86328125,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,2.0,9.0,64.3160733549083,0.0007502410180005368,Cysteine-rich extracellular repeats,True,assigned_too_few_test_positives +6672,87539,15.765963,0.90283203,Helicase,keyword,58239,P-loop containing nucleoside triphosphate hydrolase,0.7265625,81,keywords,Helicase,keyword:keywords:Helicase,6.0,2257.0,0.7402265659706797,0.11171880844011992,0.002658396101019052,0.16666666666666666,42.02489177489177,5.0,18.0,43.92941349837902,1.5542799369692752e-07,ATPase motif II coupling loop,True,assigned_and_evaluated +6673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic SP/TP-rich IDRs,False,no_term_above_threshold +6674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated linker/tail IDRs,False,no_term_above_threshold +6675,27932,36.66773,0.93603516,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.90527344,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9760198003532843,0.9435209108727202,0.01949490474080638,0.9545454545454546,48.39833399635749,15.0,15.0,103.50868055555556,1.9230759000520584e-30,Basic ribosomal RNA-binding cores,True,assigned_and_evaluated +6676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC importer first periplasmic loop,False,no_term_above_threshold +6677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic edge flanking motifs,False,no_term_above_threshold +6678,25014,18.847437,0.7661133,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.61865234,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.6267905361964767,0.06536273851105136,0.015507310589277802,,4.214962880555512,9.0,18.0,18.424289245982695,6.331674088791986e-10,Disordered acidic cytosolic regions,True,assigned_and_evaluated +6679,36104,18.370329,0.99121094,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99121094,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Surface-exposed interaction patches,True,assigned_too_few_test_positives +6680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interaction segments,False,no_term_above_threshold +6681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered docking motifs,False,no_term_above_threshold +6682,64507,39.43937,0.99560547,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99560547,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9998517200474496,0.9674523007856344,0.003987594151528578,1.0,242.61553809701965,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin repeat A-helix N-terminus,True,assigned_and_evaluated +6683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SNARE N-terminal regulatory domains,False,no_term_above_threshold +6684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal catalytic-module entry strand,False,no_term_above_threshold +6685,37282,16.136656,0.81640625,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.7441406,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,18.0,19.0,211.54701360141925,5.435829659838727e-41,Extracellular LRR N-cap/early repeats,True,assigned_too_few_test_positives +6686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Assembly interface patch,False,no_term_above_threshold +6687,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic exported ectodomains,False,no_term_above_threshold +6688,49121,17.836163,0.79345703,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.79345703,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,20.0,0.0,1.0,C-terminal hydrophobic tract activation,True,assigned_too_few_test_positives +6689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TF terminal disordered regions,False,no_term_above_threshold +6690,48767,20.292217,0.96240234,DNA-binding pseudobarrel domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8852539,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,19.0,0.0,1.0,Aromatic nucleic acid-binding motif,True,assigned_too_few_test_positives +6691,36104,23.06462,0.97802734,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.97802734,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Non-transmembrane regulatory loops,True,assigned_too_few_test_positives +6692,49236,16.152107,0.8676758,C-type lectin fold,interpro,49236,C-type lectin fold,0.8676758,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9785079928952043,0.05886299702938073,0.002215330084182543,,26.570756859062463,0.0,15.0,0.0,1.0,Signaling coiled-coil linkers,True,assigned_and_evaluated +6693,59224,33.011654,0.79833984,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.79833984,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7100952380952381,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Lipid deacylating catalytic domains,True,assigned_and_evaluated +6694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical surface signal,False,no_term_above_threshold +6695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged luminal loop signature,False,no_term_above_threshold +6696,58239,18.526482,0.7128906,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7128906,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7853292737934146,0.1960237525812767,0.017722640673460344,0.15,11.060640239398538,14.0,14.0,35.851473241130485,4.487319221459063e-22,Pre-Walker A loop,True,assigned_and_evaluated +6697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted Zn metalloprotease domains,False,no_term_above_threshold +6698,88263,35.020996,0.8803711,Zinc-finger,keyword,88263,Zinc-finger,0.8803711,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.954954218443427,0.20630476528609962,0.014621178555604785,,14.10999561365839,10.0,16.0,16.286330856643357,9.348061078670218e-11,N-terminal targeting/assembly helices,True,assigned_and_evaluated +6699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface helix,False,no_term_above_threshold +6700,37020,19.260885,0.9970703,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9814453,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,16.0,816.7260273972603,1.3609527499980455e-46,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +6701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase αF and analogous helices,False,no_term_above_threshold +6702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metalloenzyme active-site signature,False,no_term_above_threshold +6703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,XO-family Moco-binding helix motif,False,no_term_above_threshold +6704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered termini and targeting peptides,False,no_term_above_threshold +6705,31094,15.678644,0.96533203,phosphopantetheine binding,go_mf,85682,NAD(P)-binding Rossmann-like Domain,0.79052734,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9877392078326658,0.15628504178361016,0.004430660168365086,,35.273533930560816,0.0,17.0,0.0,1.0,Cofactor/metal-binding loop-helix,True,assigned_and_evaluated +6706,36449,17.589222,0.921875,EamA domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6899414,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,11.0,0.0,1.0,ABC ATPase post‑Walker‑B loop,True,assigned_too_few_test_positives +6707,50806,20.177105,0.7705078,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.7705078,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,TIM/Rossmann α/β catalytic core,True,assigned_too_few_test_positives +6708,4066,16.665617,0.80078125,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.80078125,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7835701598579041,0.04192509307263406,0.002215330084182543,,18.924987012987017,0.0,19.0,0.0,1.0,Basic nucleic-acid channel helices,True,assigned_and_evaluated +6709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NHL β-propeller repeats,False,no_term_above_threshold +6710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue Gly/Pro packing motifs,False,no_term_above_threshold +6711,27733,19.796722,0.82373047,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.82373047,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.7880678058464055,0.35180479666138476,0.0101905183872397,0.34782608695652173,34.52275765498893,14.0,18.0,41.776476476476475,4.2352396888241194e-21,Acidic transcriptional activation IDRs,True,assigned_and_evaluated +6712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short acidic Gly/Pro loops,False,no_term_above_threshold +6713,88058,19.641537,0.6220703,Signal,keyword,88058,Signal,0.6220703,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6355282528532138,0.11446968558990366,0.09127159946832078,,1.2541654387204493,2.0,20.0,0.7204954682779456,1.0,Polar low-complexity disordered repeats,True,assigned_and_evaluated +6714,47717,16.454441,0.98046875,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6772461,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,17.0,0.0,1.0,REC alpha1 helix activation,True,assigned_too_few_test_positives +6715,88058,18.855516,0.6020508,Signal,keyword,88058,Signal,0.6020508,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6079665140850071,0.10562480683988093,0.09127159946832078,,1.1572581992117053,3.0,20.0,1.0807432024169183,0.8334769282943363,Short disordered targeting modules,True,assigned_and_evaluated +6716,59224,26.952948,0.97509766,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97509766,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9995555555555555,0.9285714285714286,0.0031014621178555605,1.0,299.3979591836735,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Serine hydrolase nucleophile elbow,True,assigned_and_evaluated +6717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Principal folded core domain,False,no_term_above_threshold +6718,85364,25.595701,0.9770508,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9770508,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,18.0,301.1161616161616,2.0260096530472245e-44,Extended polar ligand-binding regions,True,assigned_too_few_test_positives +6719,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helical micro-motif,False,no_term_above_threshold +6720,38317,20.005476,0.99853516,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8798828,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,20.0,365.4190322580645,1.8534282920924948e-47,PPR helix A hydrophobic anchor,True,assigned_and_evaluated +6721,49116,23.244081,0.96484375,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.96484375,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9988454706927176,0.7247619047619047,0.002215330084182543,0.8,327.1575238095238,18.0,20.0,78.33416058394161,8.069857698062721e-33,Alpha-solenoid helix-coil hinges,True,assigned_and_evaluated +6722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intrinsically disordered regulatory regions,False,no_term_above_threshold +6723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr beta-alpha junction motif,False,no_term_above_threshold +6724,38873,20.288366,0.9892578,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9536133,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.99702486678508,0.37238095238095237,0.002215330084182543,0.4,168.09276190476191,17.0,20.0,145.62600574712644,4.187803824800725e-35,Walker A P-loop lysine,True,assigned_and_evaluated +6725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helices,False,no_term_above_threshold +6726,88147,15.947071,0.6430664,Toxin-antitoxin system,keyword,88147,Toxin-antitoxin system,0.6430664,120,keywords,Toxin-antitoxin system,keyword:keywords:Toxin-antitoxin system,10.0,2257.0,0.5739207832665777,0.10571844117817034,0.004430660168365086,0.1,23.860652173913046,18.0,18.0,236.59126984126982,1.243423145389655e-42,Divalent-metal active-site loops,True,assigned_and_evaluated +6727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic structural scaffold,False,no_term_above_threshold +6728,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sandwich/OB-fold core detector,False,no_term_above_threshold +6729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal segment,False,no_term_above_threshold +6730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IF rod and CHCH helices,False,no_term_above_threshold +6731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand termini and loops,False,no_term_above_threshold +6732,63774,22.836695,0.984375,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.984375,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,17.0,0.0,1.0,Terminal beta-edge interface strands,True,assigned_too_few_test_positives +6733,72011,21.593319,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9482422,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,14.0,17.0,486.13511939429236,2.4178087537758372e-36,Conserved ANL AMP-binding patch,True,assigned_too_few_test_positives +6734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic active-site loops,False,no_term_above_threshold +6735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded beta-strand cores,False,no_term_above_threshold +6736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-sandwich with acidic tails,False,no_term_above_threshold +6737,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor adjacent functional segment,False,no_term_above_threshold +6738,87697,23.726776,0.91015625,Knottin,keyword,87697,Knottin,0.91015625,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9692550461261012,0.20717180622946677,0.017279574656623838,,11.989404273330935,0.0,19.0,0.0,1.0,Beta-edge glycine hinge loops,True,assigned_and_evaluated +6739,31094,15.85486,0.9975586,phosphopantetheine binding,go_mf,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9848633,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9992879394748555,0.796024531024531,0.004430660168365086,1.0,179.66273665223665,13.0,14.0,659.0756802721089,2.5820292060120413e-36,N-terminal docking/capping segment,True,assigned_and_evaluated +6740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich SH3/EVH1-binding IDRs,False,no_term_above_threshold +6741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartic protease active-site flap,False,no_term_above_threshold +6742,81858,16.010712,0.8076172,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8076172,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Membrane transferase TM-helix signature,True,assigned_too_few_test_positives +6743,46932,17.884241,0.88378906,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.88378906,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.8755006675567423,0.04006575433904205,0.004430660168365086,,9.042840754321793,0.0,15.0,0.0,1.0,Short beta-strand signal,True,assigned_and_evaluated +6744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature-region surface segments,False,no_term_above_threshold +6745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich adhesion/interaction modules,False,no_term_above_threshold +6746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged regions and conserved motifs,False,no_term_above_threshold +6747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory interaction surfaces,False,no_term_above_threshold +6748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered G-patch/RGG modules,False,no_term_above_threshold +6749,15821,15.7675905,0.69873047,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.69873047,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,14.0,0.0,1.0,β-rich domain boundary segments,True,assigned_too_few_test_positives +6750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding loop-helix motif,False,no_term_above_threshold +6751,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Catalytic beta-alpha junctions, TM scaffolds",False,no_term_above_threshold +6752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-start boundary,False,no_term_above_threshold +6753,59211,18.072805,0.8691406,Nucleotide-diphospho-sugar transferases,interpro,87525,Glycosyltransferase,0.7495117,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.5643996415770609,0.06384984089902122,0.011076650420912717,,5.764363636363636,5.0,17.0,71.8671648987464,1.3225228393227056e-08,Bacterial glycoenzyme peripheral activation,True,assigned_and_evaluated +6754,87970,20.428328,0.8310547,Protein phosphatase,keyword,87970,Protein phosphatase,0.8310547,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,11.0,13.0,243.71274619100706,1.6149049880127042e-25,PTP/DSP fold regulatory flanks,True,assigned_too_few_test_positives +6755,52941,21.628119,0.9995117,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.98583984,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,20.0,20.0,260.353711790393,9.072183617335922e-48,Juxtamembrane helix-start motifs,True,assigned_too_few_test_positives +6756,28622,16.031326,0.78271484,transposase activity,go_mf,88163,Transposable element,0.63964844,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.8934724689165187,0.4015541771279476,0.002215330084182543,0.6,181.26155555555556,2.0,20.0,114.65576923076922,0.00025494042955466787,Phosphate/acyl transfer catalytic cores,True,assigned_and_evaluated +6757,88058,24.608183,0.65234375,Signal,keyword,88058,Signal,0.65234375,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6380903466459648,0.11615785935544717,0.09127159946832078,,1.272661594976914,2.0,20.0,0.7204954682779456,1.0,N-terminal disordered propeptide signature,True,assigned_and_evaluated +6758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered and coiled-coil C-terminal tails,False,no_term_above_threshold +6759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terpene synthase/Cas8 C-terminal regions,False,no_term_above_threshold +6760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic/lumenal TM–loop boundaries,False,no_term_above_threshold +6761,84152,22.881416,0.87890625,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.87890625,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,1.0,16.0,35.15389150943396,0.04684068775106677,Active-site rim transition motif,True,assigned_too_few_test_positives +6762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro-rich regulatory IDRs,False,no_term_above_threshold +6763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-barrel lipid-transfer interfaces,False,no_term_above_threshold +6764,85649,40.82154,0.9868164,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98095703,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8885212720407926,0.6740527362953268,0.0101905183872397,0.782608695652174,66.1450880790675,14.0,16.0,96.78733766233765,7.851474713119925e-27,SAM motif III beta-strand,True,assigned_and_evaluated +6765,87276,37.578354,0.6748047,Cell membrane,keyword,88161,Transmembrane helix,0.64697266,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8000272092090263,0.5339809184721838,0.11120957022596367,0.649402390438247,4.801573438214019,9.0,17.0,4.344076358867246,0.00010466092364122336,TM helix entry motif,True,assigned_and_evaluated +6766,36876,17.127085,0.9458008,Cytochrome P450,interpro,36876,Cytochrome P450,0.9458008,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9988631870304469,0.6439814814814815,0.003987594151528578,1.0,161.4962448559671,0.0,17.0,0.0,1.0,Oxyanion-stabilizing active-site clusters,True,assigned_and_evaluated +6767,36535,20.138779,0.9506836,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9506836,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9485981308411214,0.9004430660168365,0.004430660168365086,0.9,203.23000000000002,17.0,18.0,84.80229250334672,3.8870572868929705e-32,Kinase C-terminal regulatory extensions,True,assigned_and_evaluated +6768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered secondary-structure signal,False,no_term_above_threshold +6769,37690,32.87415,0.9975586,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9975586,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9995555555555555,0.8486394557823129,0.0031014621178555605,1.0,273.62560738581146,19.0,19.0,180.66969696969696,9.999012036670754e-43,Ankyrin intra-repeat register,True,assigned_and_evaluated +6770,39177,16.044142,0.77734375,Fibronectin type III,interpro,39177,Fibronectin type III,0.77734375,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,0.0,17.0,0.0,1.0,Bacterial N-terminal Ig-like beta-strands,True,assigned_too_few_test_positives +6771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain-IDR boundary signal,False,no_term_above_threshold +6772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic helix near catalytic zinc,False,no_term_above_threshold +6773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated low-complexity IDRs,False,no_term_above_threshold +6774,37071,16.139786,0.96728516,Homeodomain,interpro,37071,Homeodomain,0.96728516,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,13.0,0.0,1.0,Helix N-cap initiation motif,True,assigned_too_few_test_positives +6775,88160,19.24477,0.8178711,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6796875,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,20.0,231.5378640776699,6.036645647116142e-36,Gram-negative outer-membrane beta-barrels,True,assigned_too_few_test_positives +6776,37312,16.244347,0.9746094,"DNA-binding HTH domain, TetR-type",interpro,36535,Protein kinase domain,0.8955078,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,18.0,0.0,1.0,Acidic–aromatic CA ATP-lid loops,True,assigned_too_few_test_positives +6777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/HAMP/dCACHE sensory modules,False,no_term_above_threshold +6778,48883,16.938232,0.95751953,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.95751953,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,0.0,14.0,0.0,1.0,ALDH xVGxP loop motif,True,assigned_too_few_test_positives +6779,37020,17.703293,0.9941406,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.97802734,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,19.0,730.7548666186012,2.5754498304135963e-47,Nucleotide-sugar pyrophosphate-binding loop,True,assigned_too_few_test_positives +6780,36977,15.995477,0.96191406,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.88964844,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,12.0,0.0,1.0,Glycine-rich phosphate-binding loops,True,assigned_too_few_test_positives +6781,87413,16.822184,0.6333008,Disulfide bond,keyword,87413,Disulfide bond,0.6333008,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.47594802439671174,0.08213703818154353,0.0717766947275144,,1.1443413282453316,3.0,16.0,2.2176031541360843,0.23563492781011672,M13 domain conserved non-catalytic peaks,True,assigned_and_evaluated +6782,61392,36.08374,0.99853516,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.99853516,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9984126984126984,0.5076891362605648,0.0031014621178555605,1.0,163.69348293429925,15.0,18.0,139.562265917603,1.0223966431533665e-30,LRR concave strand-loop motif,True,assigned_and_evaluated +6783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory regions outside active sites,False,no_term_above_threshold +6784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity linkers/tails,False,no_term_above_threshold +6785,25167,17.687237,0.74560547,cell outer membrane,go_cc,25167,cell outer membrane,0.74560547,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9972902746844841,0.6057205294705293,0.005316792202038104,0.9166666666666666,113.92593625124871,17.0,17.0,136.43249427917618,2.1317050597631678e-36,Outer membrane beta-barrels,True,assigned_and_evaluated +6786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphorylase Pro/Ser-rich pre-phosphate loop,False,no_term_above_threshold +6787,36977,18.273651,0.9736328,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.88671875,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,3.0,13.0,71.65985576923077,1.7177987268381307e-05,Protein kinase alphaC helix,True,assigned_too_few_test_positives +6788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arrestin-fold mid-chain/linker activation,False,no_term_above_threshold +6789,63960,37.091854,0.9423828,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9423828,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,16.0,16.0,193.57467532467533,1.0288461071936617e-36,N-terminal FAD-binding segment,True,assigned_too_few_test_positives +6790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Caspase-like cysteine protease core,False,no_term_above_threshold +6791,36010,18.092428,0.9995117,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97265625,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,17.0,19.0,455.9410706252812,7.976975571869202e-44,Hydrolase nucleophile elbow activation,True,assigned_too_few_test_positives +6792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP transpeptidase strand-helix motif,False,no_term_above_threshold +6793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular juxtamembrane loop activation,False,no_term_above_threshold +6794,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH1 GWF helix hotspot,False,no_term_above_threshold +6795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positive-inside signal-anchor motif,False,no_term_above_threshold +6796,69819,21.9853,0.88134766,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8598633,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,15.0,15.0,419.86619718309856,1.6608451341010338e-39,Active-site helix-loop flap,True,assigned_too_few_test_positives +6797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,YDxxGx beta-strand junction motif,False,no_term_above_threshold +6798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial transmembrane and linker helices,False,no_term_above_threshold +6799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed beta-strand edge patches,False,no_term_above_threshold +6800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,7TM membrane helix bundle,False,no_term_above_threshold +6801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-flanking β-loop-α patch,False,no_term_above_threshold +6802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycoprotein ectodomains,False,no_term_above_threshold +6803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transcription factor activation motifs,False,no_term_above_threshold +6804,45324,19.226942,0.7998047,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.7998047,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.49578152753108345,0.002215330084182543,0.002215330084182543,,1.0,12.0,15.0,437.58532110091744,1.314377206300329e-30,Post-signal beta-helix seeding motif,True,assigned_and_evaluated +6805,81799,16.979858,0.9506836,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,5.0,15.0,192.9482200647249,8.774470052306479e-11,C-terminal helical lid/linker coupler,True,assigned_too_few_test_positives +6806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide cysteine and propeptide motifs,False,no_term_above_threshold +6807,87601,15.853376,0.6166992,Hydrolase,keyword,87601,Hydrolase,0.6166992,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.598621509904851,0.08667930199648961,0.05316792202038104,,1.6302932050506422,6.0,17.0,3.9472342679333976,0.004586023288384175,Active-site flanking loops,True,assigned_and_evaluated +6808,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane anchors and periplasmic N-termini,False,no_term_above_threshold +6809,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic trimeric coiled-coil stalks,False,no_term_above_threshold +6810,85388,25.386095,0.71972656,Glutaredoxin,gene3d,85388,Glutaredoxin,0.71972656,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.6756058248110272,0.23398616341751585,0.003544528134692069,0.25,66.01334635416666,14.0,16.0,189.7031818181818,6.676592570985732e-31,Mature secretory lumenal domains,True,assigned_and_evaluated +6811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fibrillar adhesin stalk regions,False,no_term_above_threshold +6812,64317,17.278423,0.8388672,"Knottin, scorpion toxin-like superfamily",interpro,64317,"Knottin, scorpion toxin-like superfamily",0.8388672,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,20.0,0.0,1.0,Strand–coil boundary loops,True,assigned_too_few_test_positives +6813,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core alpha-helix signal,False,no_term_above_threshold +6814,85664,18.599909,0.79785156,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.79785156,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Glycosyltransferase donor binding segment,True,assigned_too_few_test_positives +6815,88163,18.554327,0.68115234,Transposable element,keyword,88163,Transposable element,0.68115234,122,keywords,Transposable element,keyword:keywords:Transposable element,11.0,2257.0,0.5786448635958876,0.11762395778789222,0.004873726185201595,0.09090909090909091,24.13429752066116,2.0,17.0,30.364654952890245,0.0034012828812999196,CENPB HTH-DDE linker activation,True,assigned_and_evaluated +6816,29104,19.88159,0.71777344,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.7060547,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,15.0,0.0,1.0,TM helix N-cap anchors,True,assigned_too_few_test_positives +6817,39971,17.809704,0.8100586,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.7949219,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,10.0,0.0,1.0,Pre-catalytic N-terminal tail,True,assigned_too_few_test_positives +6818,37341,15.897129,0.9248047,WD40 repeat,interpro,88009,Repeat,0.6430664,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.8743398106626805,0.0437674613445771,0.011962782454585734,,3.658635564989278,0.0,18.0,0.0,1.0,Small-residue beta-strand motif,True,assigned_and_evaluated +6819,63831,23.755922,0.9277344,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9277344,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9596475640456094,0.036666391344950186,0.002658396101019052,,13.792674210925428,0.0,19.0,0.0,1.0,Proline-anchored strand-loop boundaries,True,assigned_and_evaluated +6820,59224,23.29908,0.94140625,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7729492,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9779047619047618,0.09967210209145694,0.0031014621178555605,,32.137133488631186,0.0,15.0,0.0,1.0,Active-site cofactor-binding loops,True,assigned_and_evaluated +6821,88161,64.57178,0.72753906,Transmembrane helix,keyword,88161,Transmembrane helix,0.72753906,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7606382285475967,0.5868122355057941,0.1847585290208241,0.6306954436450839,3.176103634380281,11.0,11.0,5.4274920345926265,1.6633903518332707e-08,TM helix C-terminal exit,True,assigned_and_evaluated +6822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter terminal and loop disorder,False,no_term_above_threshold +6823,25167,17.092857,0.72802734,cell outer membrane,go_cc,25167,cell outer membrane,0.72802734,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9545100222717149,0.5739281457519162,0.005316792202038104,0.8333333333333334,107.94631874683957,19.0,20.0,129.61086956521737,2.8346608292965217e-39,Outer-membrane beta-barrel signature,True,assigned_and_evaluated +6824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed beta-edge interaction loops,False,no_term_above_threshold +6825,85649,39.1883,0.9501953,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9482422,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.86635397610058,0.7029950964377193,0.0101905183872397,0.7391304347826086,68.98521446347532,12.0,14.0,94.81208587331035,6.665923154049817e-23,C-terminal SAM-MTase lid/extensions,True,assigned_and_evaluated +6826,88058,18.784014,0.6098633,Signal,keyword,88058,Signal,0.6098633,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6169663862761712,0.1071667325924063,0.09127159946832078,,1.1741520168012671,4.0,20.0,1.4409909365558913,0.4670478563492871,Sparse internal aliphatic peaks,True,assigned_and_evaluated +6827,88263,18.641588,0.7211914,Zinc-finger,keyword,88263,Zinc-finger,0.7211914,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.7636663396555483,0.042849688614887194,0.014621178555604785,,2.9306590061757696,1.0,16.0,1.6286330856643356,0.7238924597049627,N-terminal β1 nucleation motif,True,assigned_and_evaluated +6828,37468,26.39073,0.96728516,"Zinc finger, RING-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.89404297,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,18.0,18.0,137.37557603686636,1.6332112516921354e-38,RING E3 accessory regions,True,assigned_too_few_test_positives +6829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Deacetylase catalytic-groove helices,False,no_term_above_threshold +6830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved short hydrophobic motif detector,False,no_term_above_threshold +6831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-based metal-binding active sites,False,no_term_above_threshold +6832,82029,27.18189,0.99853516,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.98876953,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Cytosolic N-cap gating helices,True,assigned_too_few_test_positives +6833,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FG/proline-rich low-complexity IDRs,False,no_term_above_threshold +6834,83419,19.060965,0.8881836,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.8515625,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,13.0,20.0,236.30274390243903,8.537240167437389e-29,Aromatic sugar-clamp loops,True,assigned_too_few_test_positives +6835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FG-rich low-complexity IDRs,False,no_term_above_threshold +6836,47529,18.395397,0.89697266,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.89697266,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9038654618473894,0.06937648936999433,0.007089056269384138,,9.786421031754825,1.0,15.0,5.155296152183312,0.28102302916228994,N-terminus and beta-strand boundary peaks,True,assigned_and_evaluated +6837,82029,30.764973,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS TM8 small-residue helix,True,assigned_too_few_test_positives +6838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand start detector,False,no_term_above_threshold +6839,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic packing signal,False,no_term_above_threshold +6840,47529,28.245176,0.9770508,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9770508,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.963409192324855,0.6194537313805731,0.007089056269384138,0.6875,87.3816919828721,15.0,18.0,64.4412019022914,1.0108141398209011e-25,Beta-sandwich interdomain hinge linkers,True,assigned_and_evaluated +6841,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal nucleic-acid docking,False,no_term_above_threshold +6842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interaction arms,False,no_term_above_threshold +6843,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered nonfunctional residue detector,False,no_term_above_threshold +6844,87276,33.240776,0.6333008,Cell membrane,keyword,88161,Transmembrane helix,0.61572266,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6378940866643098,0.32613656526634166,0.11120957022596367,0.3107569721115538,2.932630389665869,12.0,18.0,5.470318377832829,1.9063299488550125e-07,Single transmembrane helix detector,True,assigned_and_evaluated +6845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Modular signaling recruitment domains,False,no_term_above_threshold +6846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Assembly-associated low-complexity segments,False,no_term_above_threshold +6847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged S/T-rich IDRs,False,no_term_above_threshold +6848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-site proximal helix/loop elements,False,no_term_above_threshold +6849,25325,15.632047,0.61279297,membrane,go_cc,25325,membrane,0.61279297,1709,go,GO:0016020,go_cc:go:GO:0016020,108.0,2257.0,0.6216047946503971,0.09348694201738847,0.047851129818342934,,1.95370396419672,3.0,20.0,1.4077050212498032,0.562860493937928,Ser/Thr-rich disordered segments,True,assigned_and_evaluated +6850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal N-terminal S/T-rich IDRs,False,no_term_above_threshold +6851,36977,17.14604,0.95996094,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9404297,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,1.0,10.0,31.05260416666667,0.05275973174720483,Helix C-cap and sigma2 helices,True,assigned_too_few_test_positives +6852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix core preference,False,no_term_above_threshold +6853,64596,17.181314,0.9785156,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,4066,type II site-specific deoxyribonuclease,0.9453125,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,0.0,19.0,0.0,1.0,Metal-binding nuclease beta-strand,True,assigned_too_few_test_positives +6854,27918,15.771933,0.75097656,DNA-binding transcription factor activity,go_mf,87384,DNA-binding,0.68359375,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.6980684044637533,0.01612571722959562,0.00930438635356668,,1.7331306565332056,0.0,17.0,0.0,1.0,Low complexity helical repeats,True,assigned_and_evaluated +6855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM1 cytoplasmic juxtamembrane segment,False,no_term_above_threshold +6856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal interaction helix-tail,False,no_term_above_threshold +6857,85672,28.44487,0.65722656,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6484375,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6208039421681926,0.14213822768757572,0.01595037660611431,0.1111111111111111,8.911277219190511,9.0,9.0,40.01409395973155,8.640244049603615e-15,P-loop NTPase C-terminal lobe,True,assigned_and_evaluated +6858,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved micro-motif detector,False,no_term_above_threshold +6859,87786,22.250893,0.71777344,Mitochondrion inner membrane,keyword,87785,Mitochondrion,0.6269531,163,keywords,Mitochondrion inner membrane,keyword:keywords:Mitochondrion inner membrane,15.0,2257.0,0.7895331549212015,0.31546864753605824,0.00664599025254763,0.4,47.467515832592234,16.0,18.0,77.70739654610622,3.889832427041529e-29,C-terminal post-TM mitochondrial IMS tails,True,assigned_and_evaluated +6860,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF domain-specific activation,False,no_term_above_threshold +6861,55053,20.703157,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,10.0,11.0,501.86026936026934,8.78399456430145e-27,Noncatalytic scaffolding helices,True,assigned_too_few_test_positives +6862,81685,16.555975,0.9458008,Transferase(Phosphotransferase) domain 1,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.9458008,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9853749072011879,0.5625838131432732,0.005316792202038104,0.6666666666666666,105.81263885536396,10.0,14.0,61.187397372742204,1.0217673316389772e-16,Acidic glycine-rich beta-beta loops,True,assigned_and_evaluated +6863,50338,23.437979,0.9785156,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.91064453,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Cytosolic TM-helix entry segment,True,assigned_too_few_test_positives +6864,87856,16.657595,0.7294922,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7294922,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5294494648465039,0.03192787970305534,0.012405848471422242,0.03571428571428571,2.5736151603498536,3.0,16.0,15.879172585227273,0.0014433393149582336,Acidic catalytic core architecture,True,assigned_and_evaluated +6865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-enzymatic binding modules,False,no_term_above_threshold +6866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arrestin adaptor IDR activation,False,no_term_above_threshold +6867,35372,19.644981,0.9160156,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9160156,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,15.0,17.0,618.9031141868512,7.209249871616995e-41,Multipass transporter TM helices,True,assigned_too_few_test_positives +6868,37341,28.622938,0.93115234,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.90966797,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.8984803188839063,0.35841517275533685,0.011962782454585734,0.18518518518518517,29.960853515140567,4.0,17.0,34.2157819225251,9.201996269660128e-06,Beta-propellers and extracellular loops,True,assigned_and_evaluated +6869,27932,28.812098,0.7011719,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.68408203,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.5826212874337592,0.11456251961184999,0.01949490474080638,0.06818181818181818,5.876536517362396,7.0,12.0,60.38006365740741,1.2455289822836981e-11,Release factor C-terminal extensions,True,assigned_and_evaluated +6870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Ser/Thr-rich disordered linkers,False,no_term_above_threshold +6871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TM hairpin sensor,False,no_term_above_threshold +6872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAH domain-TM activation signature,False,no_term_above_threshold +6873,87277,20.839693,0.86328125,Cell outer membrane,keyword,88058,Signal,0.70996094,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.9183809523809523,0.5008988038675323,0.0031014621178555605,0.42857142857142855,161.50408576128862,11.0,17.0,94.78696343402227,4.070834414948419e-20,Gram-negative Sec signal peptides,True,assigned_and_evaluated +6874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-dotted acidic low-complexity segments,False,no_term_above_threshold +6875,31094,16.966072,0.92333984,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.79541016,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9477525589675123,0.7322155527893233,0.004430660168365086,0.7,165.26105026455028,0.0,12.0,0.0,1.0,Secreted lytic hydrolase catalytic cores,True,assigned_and_evaluated +6876,46932,16.14705,0.9003906,Zinc finger C2H2-type,interpro,43624,Homedomain-like superfamily,0.89208984,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9685135736537607,0.20828058914265812,0.004430660168365086,,47.008928969497944,2.0,14.0,15.457868809955922,0.012349496700384405,Secondary structure boundary residues,True,assigned_and_evaluated +6877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,First N-terminal secondary element,False,no_term_above_threshold +6878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type V secretion initiation segment,False,no_term_above_threshold +6879,81858,15.761845,0.8720703,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6669922,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Juxtamembrane cap segments,True,assigned_too_few_test_positives +6880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar export/assembly segments,False,no_term_above_threshold +6881,27735,15.96493,0.77001953,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,88150,Transcription regulation,0.6269531,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.7505689066648277,0.047553700224325854,0.011519716437749225,,4.128026977165518,16.0,20.0,36.18877086494689,3.762535791186346e-23,Q/H-rich disordered activation domains,True,assigned_and_evaluated +6882,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclase active-site proximal segment,False,no_term_above_threshold +6883,87732,16.121948,0.7504883,Lipid transport,keyword,87732,Lipid transport,0.7504883,44,keywords,Lipid transport,keyword:keywords:Lipid transport,,,,,,,,4.0,15.0,66.52273361227337,6.459303201813728e-07,Extracellular lipid-interaction modules,True,assigned_too_few_test_positives +6884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-rich helical lids/hinges,False,no_term_above_threshold +6885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asn-centered PCMH FAD loop,False,no_term_above_threshold +6886,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavodoxin-like C-terminal helix-loop,False,no_term_above_threshold +6887,46284,17.113913,0.796875,FMN-binding split barrel,interpro,46277,"Nucleic acid-binding, OB-fold",0.7011719,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,7.0,14.0,596.21,1.606207013329857e-18,Basic polyanion-binding surfaces,True,assigned_too_few_test_positives +6888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helix,False,no_term_above_threshold +6889,36535,18.745583,0.8720703,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8491211,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9365821094793058,0.15638766397207277,0.004430660168365086,,35.296695758496824,0.0,7.0,0.0,1.0,ABC NBD catalytic hydrophobic patch,True,assigned_and_evaluated +6890,27013,19.289799,0.74121094,side of membrane,go_cc,87276,Cell membrane,0.6010742,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.4782318969346957,0.002658396101019052,0.002658396101019052,,1.0,0.0,19.0,0.0,1.0,Hydrophobic transmembrane helix cores,True,assigned_and_evaluated +6891,66234,18.941095,0.8066406,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.8066406,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,5.0,16.0,73.93477182539682,1.1037024581510865e-08,Cys-amide enzyme N-terminal activation,True,assigned_too_few_test_positives +6892,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-domain linker,False,no_term_above_threshold +6893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop motifs,False,no_term_above_threshold +6894,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse whole-protein catalytic-core activation,False,no_term_above_threshold +6895,88009,34.5912,0.73876953,Repeat,keyword,88009,Repeat,0.73876953,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.706319263980982,0.21446841031331879,0.07266282676118742,0.012195121951219513,2.9515561102265884,15.0,16.0,8.311477695167286,1.9330937051818929e-13,Repeat and low-complexity Cys motifs,True,assigned_and_evaluated +6896,45551,16.39433,0.88720703,SKP1/BTB/POZ domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7211914,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,17.0,0.0,1.0,RuvB-S activation motif,True,assigned_too_few_test_positives +6897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved membrane acyltransferase segment,False,no_term_above_threshold +6898,36104,16.05369,0.86816406,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.86816406,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,12.0,0.0,1.0,Pepsin-like aspartic protease domain,True,assigned_too_few_test_positives +6899,37894,22.664955,0.93408203,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.93408203,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Histidine kinase CA glycine loop,True,assigned_too_few_test_positives +6900,72011,19.010098,0.97509766,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9008789,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,Radical SAM N-terminal extensions,True,assigned_too_few_test_positives +6901,29104,16.253452,0.6748047,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.6748047,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,13.0,0.0,1.0,TM1-TM2 junction loops,True,assigned_too_few_test_positives +6902,82029,23.570307,1.0,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6118164,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,TM helix packing anchors,True,assigned_too_few_test_positives +6903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-associated assembly scaffolds,False,no_term_above_threshold +6904,87413,52.876347,0.91064453,Disulfide bond,keyword,87413,Disulfide bond,0.91064453,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9334482453814196,0.5636108237788853,0.0717766947275144,0.8765432098765432,7.852281662153976,16.0,19.0,9.95976153436557,1.1702305999732164e-14,Secretory disulfide motifs and processing,True,assigned_and_evaluated +6905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FMT PxGAFS helix-loop-strand,False,no_term_above_threshold +6906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic His-rich metal-coordination sites,False,no_term_above_threshold +6907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase catalytic core,False,no_term_above_threshold +6908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic regulatory tails; catalytic-adjacent loops,False,no_term_above_threshold +6909,48767,23.40835,0.99853516,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99853516,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,8.0,20.0,372.63124999999997,3.5444279806750486e-19,ssDNA-binding OB-fold interface,True,assigned_too_few_test_positives +6910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic surface alpha/beta interface,False,no_term_above_threshold +6911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic aromatic core module,False,no_term_above_threshold +6912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse non-catalytic helical activation,False,no_term_above_threshold +6913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FR-type FAD-binding Rossmann domain,False,no_term_above_threshold +6914,46277,21.111328,0.81689453,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.81689453,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9459847810248524,0.4708232349746333,0.004873726185201595,0.36363636363636365,96.60436739434067,0.0,17.0,0.0,1.0,Gly-rich beta-edge loops,True,assigned_and_evaluated +6915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured-domain hydrophobic patches,False,no_term_above_threshold +6916,87882,16.90745,0.74365234,Palmitate,keyword,88058,Signal,0.7011719,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8854953354064861,0.2130130361830705,0.002658396101019052,,80.12840377753167,8.0,19.0,28.048691561305496,3.4090910926511096e-10,Mature secreted protein domain,True,assigned_and_evaluated +6917,36914,20.667372,0.9980469,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9970703,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,15.0,16.0,690.0578703703703,4.5303116350019565e-42,Glycosyltransferase gating connector loop,True,assigned_too_few_test_positives +6918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ectodomain-TM juxtamembrane linker,False,no_term_above_threshold +6919,46079,16.176287,0.8144531,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8144531,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.7640717126011244,0.052549929361223484,0.0057598582188746125,0.07692307692307693,9.123476197560107,0.0,13.0,0.0,1.0,Helix caps and turns,True,assigned_and_evaluated +6920,87852,15.816055,0.82714844,Nucleosome core,keyword,87852,Nucleosome core,0.82714844,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,19.0,0.0,1.0,Nuclear RNA-processing mixed-charge IDRs,True,assigned_too_few_test_positives +6921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal regulatory helical segment,False,no_term_above_threshold +6922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BPL/LPL N-terminal acceptor-binding lobe,False,no_term_above_threshold +6923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved RNA-handling catalytic core,False,no_term_above_threshold +6924,24907,16.181025,0.68310547,extracellular space,go_cc,88058,Signal,0.60546875,241,go,GO:0005615,go_cc:go:GO:0005615,18.0,2257.0,0.7033397846260732,0.07271659829210103,0.007975188303057155,,9.117853463626224,9.0,16.0,20.94741567770144,1.4467364619502215e-10,Extracellular disulfide-stabilized domains,True,assigned_and_evaluated +6925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal functional core detector,False,no_term_above_threshold +6926,87149,18.297272,0.6074219,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6074219,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.667900403768506,0.121082239286048,0.012405848471422242,,9.760093359593226,0.0,18.0,0.0,1.0,Disordered charged C-terminal tails,True,assigned_and_evaluated +6927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic terminal docking helices,False,no_term_above_threshold +6928,64168,20.160791,0.8798828,HAD-like superfamily,interpro,55054,HAD superfamily,0.87109375,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.67797513321492,0.017167707367279714,0.002215330084182543,,7.749503105590064,0.0,15.0,0.0,1.0,Active-site adjacent helices,True,assigned_and_evaluated +6929,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured β–α interaction patches,False,no_term_above_threshold +6930,64026,36.9676,0.8881836,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.8881836,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.749333629498001,0.5013291980505095,0.002658396101019052,0.5,188.5833333333333,17.0,17.0,169.3778409090909,5.894607966578374e-38,Transporter C-terminal TM bundle,True,assigned_and_evaluated +6931,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxyanion binding scaffold residues,False,no_term_above_threshold +6932,45324,16.807035,0.9995117,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.8544922,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,12.0,18.0,364.6544342507645,4.9126567656530445e-29,Extracellular solenoid turn motifs,True,assigned_and_evaluated +6933,83302,16.177988,0.6777344,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.67333984,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.583987695296689,0.015050605214539641,0.004873726185201595,,3.0881105426559974,7.0,17.0,84.65456389452332,2.4514730324235405e-12,Nucleic-acid enzyme C-terminal signature,True,assigned_and_evaluated +6934,36886,19.683506,0.7993164,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.7993164,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.6700755891507336,0.015589745070978893,0.003544528134692069,,4.39825682814992,0.0,18.0,0.0,1.0,Proline pocket gating turn,True,assigned_and_evaluated +6935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic ligand-binding regions,False,no_term_above_threshold +6936,64058,17.231083,0.64746094,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.64746094,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8111266798293103,0.13471652144470583,0.006202924235711121,,21.718227778621504,1.0,16.0,7.12488049713193,0.21028084137787656,Terminal amphipathic interface helices,True,assigned_and_evaluated +6937,58239,25.114946,0.65966797,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.65966797,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6299221921515561,0.17197276578316267,0.017722640673460344,0.2,9.703563309314955,13.0,20.0,23.303457606734817,9.053997763361595e-16,Pre-NBD transition motif,True,assigned_and_evaluated +6938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic ssRNA-binding surfaces,False,no_term_above_threshold +6939,85762,35.730385,0.8964844,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.8720703,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,13.0,13.0,205.58965517241379,2.4985932607894418e-30,Rossmann-like α/β cofactor-binding core,True,assigned_too_few_test_positives +6940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed helix-loop caps,False,no_term_above_threshold +6941,38873,17.784834,0.8310547,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7080078,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8964476021314387,0.6731703387441093,0.002215330084182543,0.6,303.8690909090909,14.0,14.0,171.32471264367817,1.6994884608024663e-31,ABC NBD post-Walker A motif,True,assigned_and_evaluated +6942,45321,16.490274,0.93066406,Quinoprotein alcohol dehydrogenase-like superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8857422,27,ip,IPR011047,interpro:ip:IPR011047,,,,,,,,18.0,19.0,482.7611336032389,3.1113490681660496e-47,Beta-propeller blade strand-loops,True,assigned_too_few_test_positives +6943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered helical segment marker,False,no_term_above_threshold +6944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal FMN phosphate-binding loop,False,no_term_above_threshold +6945,85656,19.265842,0.9707031,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.96972656,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9915555555555555,0.1768073593073593,0.0031014621178555605,,57.007744279529994,0.0,15.0,0.0,1.0,SAM-dependent methyltransferase active-site motifs,True,assigned_and_evaluated +6946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OmpR/PhoB DBD Trp motif,False,no_term_above_threshold +6947,45714,20.688908,0.8354492,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,86137,Helix-loop-helix DNA-binding domain,0.82714844,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,16.0,0.0,1.0,Flexible histidine kinase hinge loops,True,assigned_too_few_test_positives +6948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecG Wedge motif sensor,False,no_term_above_threshold +6949,36104,17.981754,0.9423828,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.9291992,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Catalytic domain helical scaffolds,True,assigned_too_few_test_positives +6950,36104,31.348091,0.94970703,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.94970703,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Fe–S/flavin structural core activation,True,assigned_too_few_test_positives +6951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid scaffolds and porins,False,no_term_above_threshold +6952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory modules,False,no_term_above_threshold +6953,46277,16.098267,0.90527344,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.90527344,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9669715858495912,0.12700314696141568,0.004873726185201595,0.09090909090909091,26.05873660835593,6.0,15.0,75.23154574132492,2.1742556109186183e-10,Hydrophobic beta-strand packing,True,assigned_and_evaluated +6954,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane hairpin loop module,False,no_term_above_threshold +6955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1 juxtamembrane signaling segment,False,no_term_above_threshold +6956,47529,16.770483,0.8286133,Immunoglobulin-like fold,interpro,87697,Knottin,0.81884766,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9318802989736725,0.05038018828589405,0.007089056269384138,,7.106755310078929,0.0,17.0,0.0,1.0,uS17 VGDxV-adjacent peak,True,assigned_and_evaluated +6957,47529,24.847929,0.9790039,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9790039,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9904897367246764,0.549867948487273,0.007089056269384138,0.375,77.56574748348595,16.0,17.0,72.78065156023499,3.195650738846513e-29,Disulfide-proximal hydrophobic beta-strands,True,assigned_and_evaluated +6958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered interfaces and acidic motifs,False,no_term_above_threshold +6959,50338,17.417524,0.9272461,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.83935547,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,12.0,0.0,1.0,Aromatic/basic helix N-cap motif,True,assigned_too_few_test_positives +6960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Distal C-terminal CAZyme subdomains,False,no_term_above_threshold +6961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PDZ-flanking low-complexity IDRs,False,no_term_above_threshold +6962,87317,18.942612,0.8544922,Cleavage on pair of basic residues,keyword,88058,Signal,0.78027344,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9500083668005355,0.1909886695096652,0.007089056269384138,,26.941339192707147,0.0,20.0,0.0,1.0,Post-signal-peptide N-terminal IDR,True,assigned_and_evaluated +6963,36272,16.260916,0.9316406,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9316406,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,10.0,0.0,1.0,Lipid biosynthesis TM helix bundle,True,assigned_too_few_test_positives +6964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular ectodomain activation,False,no_term_above_threshold +6965,37894,19.609869,0.99560547,Short-chain dehydrogenase/reductase SDR,interpro,37468,"Zinc finger, RING-type",0.83740234,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,6.0,0.0,1.0,ABC NBD hydrophobic beta-strands,True,assigned_too_few_test_positives +6966,66234,16.562725,0.765625,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.765625,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,5.0,17.0,69.58566760037348,1.550170859482114e-08,Cysteine acyl-enzyme active-site lobe,True,assigned_too_few_test_positives +6967,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue capping turns,False,no_term_above_threshold +6968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure hinge caps,False,no_term_above_threshold +6969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic surface loop patch,False,no_term_above_threshold +6970,85672,27.554415,0.65283203,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.65234375,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7001663414878183,0.2233182131214585,0.01595037660611431,0.2222222222222222,14.000811305975885,18.0,19.0,37.90808901448251,8.198682763328136e-28,Nucleotide-binding lid helix,True,assigned_and_evaluated +6971,87276,36.97548,0.6791992,Cell membrane,keyword,88161,Transmembrane helix,0.6669922,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7902507616592455,0.5842108036335778,0.11120957022596367,0.6254980079681275,5.253242166537789,12.0,14.0,7.033266485785065,1.5735186737564993e-09,Helix-to-cytosol transition motif,True,assigned_and_evaluated +6972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered beta-turn motifs,False,no_term_above_threshold +6973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic protein region signature,False,no_term_above_threshold +6974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase proton-donor cleft,False,no_term_above_threshold +6975,52941,21.736008,0.99902344,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9902344,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,19.0,19.0,260.353711790393,1.5255431321768337e-45,Hydrophobic TM-helix interface anchors,True,assigned_too_few_test_positives +6976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature secretory membrane protein signature,False,no_term_above_threshold +6977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane soluble interface segments,False,no_term_above_threshold +6978,45290,28.461248,0.9682617,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9682617,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9969834087481146,0.8946886446886444,0.0057598582188746125,0.9230769230769231,155.33171315863618,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase β3 VAIK hydrophobic residue,True,assigned_and_evaluated +6979,63951,17.20867,0.95751953,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.94873047,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9945630684064848,0.33532708032708025,0.003987594151528578,0.2222222222222222,84.09258003313558,0.0,19.0,0.0,1.0,Flexible solvent-exposed loops,True,assigned_and_evaluated +6980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mobile active-site gating loops,False,no_term_above_threshold +6981,39971,23.633978,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,13.0,15.0,574.1281481481482,4.6331072063227474e-35,Divalent metallophosphoesterase catalytic scaffold,True,assigned_too_few_test_positives +6982,88058,33.13871,0.63134766,Signal,keyword,88058,Signal,0.63134766,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5730510335947893,0.17218436888743374,0.09127159946832078,0.08737864077669903,1.8865054397035823,17.0,19.0,6.446538400381619,7.432889592374928e-13,N-terminal Sec signal peptides,True,assigned_and_evaluated +6983,36272,18.839457,0.99902344,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.99902344,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,11.0,0.0,1.0,Catalytic cores and C-terminal juxtamembranes,True,assigned_too_few_test_positives +6984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic PG/beta-lactam linkers,False,no_term_above_threshold +6985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helix activation,False,no_term_above_threshold +6986,42054,16.661425,1.0,Radical SAM,interpro,87105,4Fe-4S,0.71972656,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,16.0,16.0,677.5113636363636,2.854844545958869e-45,Radical SAM core beta/alpha motif,True,assigned_too_few_test_positives +6987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich regulatory IDRs,False,no_term_above_threshold +6988,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-pocket helix-loop signature,False,no_term_above_threshold +6989,87326,39.110104,0.72021484,Coiled coil,keyword,87326,Coiled coil,0.72021484,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7292668642978564,0.3119160968125081,0.03943287549844927,0.3595505617977528,7.910052028155402,17.0,18.0,11.907109795352552,7.798097521564164e-18,Coiled-coil heptad stripe,True,assigned_and_evaluated +6990,85649,30.398205,0.97998047,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97265625,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8840839204390641,0.6284694579801868,0.0101905183872397,0.7391304347826086,61.67198115918615,15.0,15.0,110.61410018552876,7.1622047874657735e-31,Post-motif III lid loop,True,assigned_and_evaluated +6991,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain/tail marker,False,no_term_above_threshold +6992,38317,19.395412,0.7182617,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7182617,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6367301587301587,0.028241935058155938,0.0031014621178555605,,9.106006775179708,0.0,18.0,0.0,1.0,Noncatalytic extracellular stalk/linker,True,assigned_and_evaluated +6993,85649,40.067165,0.96533203,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.95947266,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8864680238215717,0.6130904247079516,0.0101905183872397,0.6086956521739131,60.162829937645505,12.0,12.0,110.61410018552876,7.925049903530729e-25,Methyltransferase acceptor-binding loop,True,assigned_and_evaluated +6994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type-3 copper tyrosinase domain,False,no_term_above_threshold +6995,87276,32.31837,0.6323242,Cell membrane,keyword,88161,Transmembrane helix,0.61816406,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7341074386402545,0.5193903637757404,0.11120957022596367,0.50199203187251,4.670374705346001,11.0,15.0,6.017350215616111,1.4694290198986936e-07,Pre-TM helix caps,True,assigned_and_evaluated +6996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered regions and linkers,False,no_term_above_threshold +6997,47529,20.151386,0.9243164,Immunoglobulin-like fold,interpro,87697,Knottin,0.89746094,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9521558456046408,0.11283362976468612,0.007089056269384138,,15.916593898681036,0.0,15.0,0.0,1.0,Acidic/glycine interface loops,True,assigned_and_evaluated +6998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal recognition and anchoring motifs,False,no_term_above_threshold +6999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and internal helices,False,no_term_above_threshold +7000,50338,15.986442,0.85546875,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.81103516,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,DHp coiled-coil hydrophobic anchors,True,assigned_too_few_test_positives +7001,37020,16.336351,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9814453,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,18.0,816.7260273972603,1.0011499841245636e-51,NDP-sugar donor recognition helix,True,assigned_too_few_test_positives +7002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positive-inside TM helix signature,False,no_term_above_threshold +7003,87852,16.852724,0.9477539,Nucleosome core,keyword,24789,nucleosome,0.93408203,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,4.0,19.0,132.1240997229917,4.582769362838184e-08,Terminal leader/anchor segments,True,assigned_too_few_test_positives +7004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue functional helix sites,False,no_term_above_threshold +7005,83423,16.062126,0.9707031,Galactose-binding domain-like,gene3d,83423,Galactose-binding domain-like,0.9707031,29,gene3d,2.60.120.260,gene3d:gene3d:2.60.120.260,,,,,,,,7.0,19.0,125.5178947368421,1.8327534687783782e-13,Glycan-binding beta-sheet interfaces,True,assigned_too_few_test_positives +7006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured domain binding hotspots,False,no_term_above_threshold +7007,87326,26.745789,0.6479492,Coiled coil,keyword,87326,Coiled coil,0.6479492,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.710930697790124,0.30607821517008726,0.03943287549844927,0.39325842696629215,7.76200597347064,7.0,18.0,4.902927562792228,0.0005121872646802977,Charged coiled-coil scaffold tethers,True,assigned_and_evaluated +7008,87326,42.22283,0.7998047,Coiled coil,keyword,87326,Coiled coil,0.7998047,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8207896264355902,0.34383736699552175,0.03943287549844927,0.2247191011235955,8.719561093358344,16.0,17.0,11.865908723396316,9.12494090100373e-17,Coiled-coil heptad register,True,assigned_and_evaluated +7009,64507,38.0661,0.99853516,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99853516,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat helix A core,True,assigned_and_evaluated +7010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure junction hinge,False,no_term_above_threshold +7011,36668,15.779543,0.9345703,AMP-dependent synthetase/ligase domain,interpro,88240,Virulence,0.6088867,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,20.0,0.0,1.0,Signal peptides and ectodomains,True,assigned_too_few_test_positives +7012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-exposed helix-loop junctions,False,no_term_above_threshold +7013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered helical scaffolds,False,no_term_above_threshold +7014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type II signal-anchor helix,False,no_term_above_threshold +7015,37314,16.189,0.94384766,"Helicase, C-terminal domain-like",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7416992,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,0.0,8.0,0.0,1.0,ABC H-loop His-switch motif,True,assigned_too_few_test_positives +7016,87326,24.330973,0.6269531,Coiled coil,keyword,87326,Coiled coil,0.6269531,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.647337161573863,0.1677720549062759,0.03943287549844927,0.0449438202247191,4.2546239092524125,16.0,19.0,10.616865699880913,4.307920495700391e-15,Coiled-coil heptad repeats,True,assigned_and_evaluated +7017,85656,18.337141,0.91503906,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.9145508,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9544444444444444,0.035150579438998165,0.0031014621178555605,,11.333551113402693,0.0,16.0,0.0,1.0,Active-site beta-strand starts,True,assigned_and_evaluated +7018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDRs and helix caps,False,no_term_above_threshold +7019,88164,16.727938,0.82958984,Transposition,keyword,46274,Ribonuclease H-like superfamily,0.77001953,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8980017761989344,0.7604430660168364,0.002215330084182543,0.8,343.264,2.0,15.0,96.94471544715446,0.000350293891878199,Active-site proximal loop,True,assigned_and_evaluated +7020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATPase-proximal flexible linkers,False,no_term_above_threshold +7021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solcar inter-helical linker,False,no_term_above_threshold +7022,81685,22.272964,0.9663086,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.94970703,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9960653303637713,0.7346632996632997,0.005316792202038104,0.9166666666666666,138.17792227833894,17.0,18.0,80.90333652618135,8.583072560174427e-32,SDR/kinase catalytic Ser/Asp,True,assigned_and_evaluated +7023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered histidine-basic motifs,False,no_term_above_threshold +7024,43583,16.991858,0.93652344,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.93652344,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,16.0,17.0,392.4047716988893,8.206983625628636e-41,Active-site adjacent regulatory loops,True,assigned_and_evaluated +7025,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site helical lid,False,no_term_above_threshold +7026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain helix/loop boundary motif,False,no_term_above_threshold +7027,59224,21.598694,0.72314453,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.72314453,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7763492063492065,0.11883339240479875,0.0031014621178555605,0.14285714285714285,38.31528095109011,11.0,14.0,107.937952600395,2.5763616196998664e-21,Active-site helical lids,True,assigned_and_evaluated +7028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHp/HPt phosphotransfer hairpin,False,no_term_above_threshold +7029,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-centered catalytic micro-motifs,False,no_term_above_threshold +7030,49116,24.091608,0.9819336,Armadillo-type fold,interpro,64507,Ankyrin repeat-containing domain superfamily,0.96240234,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9993783303730017,0.7544444444444445,0.002215330084182543,1.0,340.55622222222223,15.0,19.0,68.71417595082598,7.986798829557922e-26,HEAT/ARM helix C-caps,True,assigned_and_evaluated +7031,31094,16.505188,0.9741211,phosphopantetheine binding,go_mf,59224,Alpha/Beta hydrolase fold,0.6635742,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9976412995104584,0.5883880008880008,0.004430660168365086,1.0,132.7991718004218,7.0,17.0,292.2598039215686,3.921398108254727e-16,Ester/phosphoester hydrolase neighborhood,True,assigned_and_evaluated +7032,64085,21.033066,0.85253906,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.82421875,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.7401301031852848,0.25688509985851515,0.012405848471422242,0.39285714285714285,20.706773942166738,8.0,19.0,49.513962420845004,3.931704570644029e-12,C-terminal alpha-solenoid/IDR tails,True,assigned_and_evaluated +7033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PIR mannoprotein propeptide activation,False,no_term_above_threshold +7034,59229,27.426157,0.96728516,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9472656,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9373516017282317,0.4879736815667979,0.0101905183872397,0.7391304347826086,47.88506953462012,16.0,16.0,106.27629233511585,1.339381655082284e-32,SAM MTase core β-strands,True,assigned_and_evaluated +7035,37894,25.1,0.9765625,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9765625,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Histidine kinase Ser/Thr hotspots,True,assigned_too_few_test_positives +7036,48883,23.334932,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,16.0,16.0,480.8145161290322,6.075488456631373e-43,PLP-pocket strand-loop motif,True,assigned_too_few_test_positives +7037,72011,20.224144,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9482422,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,14.0,14.0,590.3069306930694,4.7603558278022205e-39,ANL C-terminal lid/linker,True,assigned_too_few_test_positives +7038,46082,17.070198,0.9453125,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9453125,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9853650793650793,0.13066760924439227,0.0031014621178555605,,42.1309705806562,0.0,14.0,0.0,1.0,Edge-loop interaction hotspots,True,assigned_and_evaluated +7039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining membrane helices,False,no_term_above_threshold +7040,64507,33.25899,0.9980469,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9980469,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat hydrophobic spine,True,assigned_and_evaluated +7041,87413,24.050655,0.6503906,Disulfide bond,keyword,88058,Signal,0.6269531,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6029096319867998,0.0932666885109652,0.0717766947275144,,1.2994007158595584,6.0,12.0,5.913608411029558,0.0003874671981213149,Active-site flank residues,True,assigned_and_evaluated +7042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycan-binding rims,False,no_term_above_threshold +7043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed helical scaffold surfaces,False,no_term_above_threshold +7044,24917,17.529324,0.6381836,nucleus,go_cc,24917,nucleus,0.6381836,1728,go,GO:0005634,go_cc:go:GO:0005634,132.0,2257.0,0.8111960784313725,0.23108430884725448,0.05848471422241914,,3.951191553547374,6.0,20.0,1.7160414468003453,0.19558729294432545,Disordered C-terminal targeting SLiMs,True,assigned_and_evaluated +7045,85656,15.805984,0.77734375,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.77734375,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8103809523809524,0.024535712562571817,0.0031014621178555605,,7.911014750532084,0.0,13.0,0.0,1.0,GG-aromatic strand-loop motif,True,assigned_and_evaluated +7046,50806,18.09742,0.7495117,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.7495117,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,9.0,0.0,1.0,Mid-sequence domain-boundary linkers,True,assigned_too_few_test_positives +7047,36499,17.195347,0.81689453,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.81689453,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,13.0,0.0,1.0,C4 zinc adjacent interaction surfaces,True,assigned_too_few_test_positives +7048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular N-terminal propeptides,False,no_term_above_threshold +7049,64155,21.248478,0.8417969,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.8378906,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,14.0,17.0,228.3704514363885,1.149317918711881e-31,Nuclease-proximal DNA-binding helix-loop,True,assigned_too_few_test_positives +7050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA-binding catalytic cores,False,no_term_above_threshold +7051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal noncatalytic scaffolds,False,no_term_above_threshold +7052,87913,20.942827,0.9995117,Phosphopantetheine,keyword,64507,Ankyrin repeat-containing domain superfamily,0.671875,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.9993949429972613,0.9588744588744589,0.006202924235711121,0.9285714285714286,154.5842609771181,18.0,18.0,480.8145161290322,6.533334885052963e-48,ACP/PCP PPant-serine region,True,assigned_and_evaluated +7053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-beta junction capping loops,False,no_term_above_threshold +7054,87586,18.130022,0.7084961,Host membrane,keyword,88161,Transmembrane helix,0.70410156,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7422936449963476,0.11943444478752112,0.01639344262295082,0.02702702702702703,7.285501132038788,2.0,16.0,8.07434994582882,0.04165345062267366,Alpha-helical transmembrane segments,True,assigned_and_evaluated +7055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity disordered segments,False,no_term_above_threshold +7056,63831,21.032585,0.94628906,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.94628906,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9358803494743078,0.022506998159759182,0.002658396101019052,,8.466382474429412,0.0,12.0,0.0,1.0,Nucleotide-binding pocket scaffold,True,assigned_and_evaluated +7057,46284,20.241478,0.97753906,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.97753906,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,19.0,0.0,1.0,Catalytic/interface edge β-hairpins,True,assigned_too_few_test_positives +7058,64026,15.90709,0.8613281,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.7597656,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9018214127054642,0.020581535236117353,0.002658396101019052,,7.742087504652811,0.0,11.0,0.0,1.0,Hydrophobic TM helical faces,True,assigned_and_evaluated +7059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-motif N-terminal segment,False,no_term_above_threshold +7060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacteriophage tape measure coiled-coil shaft,False,no_term_above_threshold +7061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exported cytochrome c pre-heme,False,no_term_above_threshold +7062,37894,27.706528,0.95996094,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7285156,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,14.0,14.0,709.7738095238095,3.3915309155506114e-40,SDR C-terminal lid helix,True,assigned_too_few_test_positives +7063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tetraspan extracellular loop marker,False,no_term_above_threshold +7064,46277,31.933893,0.92578125,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.92578125,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9972071561563992,0.5890767746185702,0.004873726185201595,0.45454545454545453,120.86784366491938,16.0,18.0,167.1812127584998,2.0721734954194948e-34,Charged nucleic acid-binding interfaces,True,assigned_and_evaluated +7065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal and loop recognition motifs,False,no_term_above_threshold +7066,64003,21.545738,0.9941406,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.79833984,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.998566627125346,0.6656084656084656,0.003987594151528578,0.8888888888888888,166.91981187536746,0.0,16.0,0.0,1.0,Histidine-centered metal-binding motifs,True,assigned_and_evaluated +7067,87465,18.506083,0.9589844,Fimbrium,keyword,88058,Signal,0.8769531,47,keywords,Fimbrium,keyword:keywords:Fimbrium,5.0,2257.0,0.8863232682060391,0.41544306601683656,0.002215330084182543,0.4,187.53100000000003,6.0,19.0,163.71899313501143,2.630316920156048e-12,Signal peptide C-region cleavage,True,assigned_and_evaluated +7068,27013,16.567291,0.79296875,side of membrane,go_cc,87522,Glycoprotein,0.60302734,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.8141566711091366,0.0705860043197522,0.002658396101019052,,26.55210195828012,0.0,20.0,0.0,1.0,Membrane-tethered soluble domains,True,assigned_and_evaluated +7069,50869,17.212255,0.8671875,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.8671875,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,14.0,0.0,1.0,Cyclase/PDE coupling linkers,True,assigned_too_few_test_positives +7070,88233,15.565696,0.8964844,Viral tail protein,keyword,88233,Viral tail protein,0.8964844,46,keywords,Viral tail protein,keyword:keywords:Viral tail protein,,,,,,,,16.0,18.0,414.0347222222222,1.120550501281114e-40,Phage tail attachment segments,True,assigned_too_few_test_positives +7071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycine rich pocket walls,False,no_term_above_threshold +7072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxyanion-binding lid region,False,no_term_above_threshold +7073,38317,15.883486,0.85058594,Pentatricopeptide repeat,interpro,87326,Coiled coil,0.6098633,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6980952380952381,0.028474440539107755,0.0031014621178555605,,9.180973185252315,0.0,19.0,0.0,1.0,C-terminal coiled-coil/IDR regulatory tails,True,assigned_and_evaluated +7074,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich flexibility/low-complexity signal,False,no_term_above_threshold +7075,85364,26.426882,0.91748047,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.91748047,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,20.0,195.72550505050506,1.0237613573715068e-27,Extracellular juxtamembrane sensing linker,True,assigned_too_few_test_positives +7076,52236,22.991003,0.99609375,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9868164,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,16.0,223.29962546816478,1.0796101345399494e-37,TPR helix-start register,True,assigned_too_few_test_positives +7077,88178,15.835502,0.6826172,Ubiquinone,keyword,6543,NADH:ubiquinone reductase (H+-translocating),0.68066406,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix-loop-helix junction,True,assigned_too_few_test_positives +7078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-binding glycine-rich loop,False,no_term_above_threshold +7079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-alpha domain cap,False,no_term_above_threshold +7080,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge short alpha-helix,False,no_term_above_threshold +7081,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-dependent ligase active site,False,no_term_above_threshold +7082,37020,16.913557,0.99316406,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9765625,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,14.0,20.0,571.7082191780821,1.0288461071936617e-36,Glycosyltransferase donor-site helix cap,True,assigned_too_few_test_positives +7083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HK CA helix-beta loops,False,no_term_above_threshold +7084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic interaction surfaces,False,no_term_above_threshold +7085,87276,34.51967,0.6411133,Cell membrane,keyword,88161,Transmembrane helix,0.6176758,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6145299162274134,0.2737500867173268,0.11120957022596367,0.2549800796812749,2.4615695048645683,10.0,11.0,7.45952506068113,1.418413254025118e-08,Interfacial loop-helix junctions,True,assigned_and_evaluated +7086,87326,17.387304,0.62060547,Coiled coil,keyword,87326,Coiled coil,0.62060547,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6429111903478586,0.10642220656119719,0.03943287549844927,,2.6988193281867647,11.0,19.0,7.299095168668129,6.365830407590611e-08,Noncatalytic helical rods and bundles,True,assigned_and_evaluated +7087,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed low-complexity regions,False,no_term_above_threshold +7088,49121,19.82846,0.95458984,"Signal transduction response regulator, C-terminal effector",interpro,80926,Homeodomain-like,0.6303711,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,17.0,17.0,977.3934426229509,1.5932300158717148e-50,HTH C-terminal basic tail,True,assigned_too_few_test_positives +7089,63960,36.0671,0.90527344,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.90527344,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,Glycine-rich Rossmann phosphate-binding loop,True,assigned_too_few_test_positives +7090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extracellular ectodomain,False,no_term_above_threshold +7091,36886,15.756571,0.671875,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.671875,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.680913739439751,0.06929866341751587,0.003544528134692069,,19.550885416666663,0.0,18.0,0.0,1.0,Helical assembly hotspot,True,assigned_and_evaluated +7092,81858,19.548405,0.7504883,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.7504883,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,16.0,0.0,1.0,ABC transporter TM helix,True,assigned_too_few_test_positives +7093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-prone Pro/Cys-rich repeats,False,no_term_above_threshold +7094,37468,16.330454,0.7338867,"Zinc finger, RING-type",interpro,37468,"Zinc finger, RING-type",0.7338867,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,15.0,19.0,108.45440213436818,8.895756262638816e-29,RING-like E3 linker loops,True,assigned_too_few_test_positives +7095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal start-of-chain detector,False,no_term_above_threshold +7096,87326,25.781485,0.61376953,Coiled coil,keyword,87326,Coiled coil,0.61376953,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6194545793772545,0.22253860961728728,0.03943287549844927,0.2247191011235955,5.643479122541769,17.0,18.0,11.907109795352552,7.798097521564164e-18,N-terminal head module activation,True,assigned_and_evaluated +7097,37690,22.046135,0.95458984,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9404297,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9722539682539683,0.08520691961062696,0.0031014621178555605,,27.47314536588358,0.0,13.0,0.0,1.0,Alpha-helix C-cap geometry,True,assigned_and_evaluated +7098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory interaction surface modules,False,no_term_above_threshold +7099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-binding helix-loop motifs,False,no_term_above_threshold +7100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil-like helices,False,no_term_above_threshold +7101,88160,16.103832,0.78271484,Transmembrane beta strand,keyword,25167,cell outer membrane,0.65625,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,12.0,15.0,231.5378640776699,3.09744253716986e-27,Outer-membrane β-barrel channels,True,assigned_too_few_test_positives +7102,85656,18.980524,0.8300781,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.8276367,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8247936507936509,0.07327540841933276,0.0031014621178555605,,23.626085257490576,7.0,19.0,52.05125966575205,8.425222086756929e-11,Extracellular hydrolase binding-groove scaffolds,True,assigned_and_evaluated +7103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central catalytic core activation,False,no_term_above_threshold +7104,83267,15.998572,0.80615234,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.80615234,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,16.0,0.0,1.0,C-terminal β–α catalytic surface,True,assigned_too_few_test_positives +7105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured-core small/hydrophobic residues,False,no_term_above_threshold +7106,69819,19.276081,0.7504883,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.74365234,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,10.0,14.0,299.9044265593561,1.2238402119187151e-23,Hsp70 C-terminal lid activation,True,assigned_too_few_test_positives +7107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered helicase C-terminal tails,False,no_term_above_threshold +7108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +7109,64026,15.596211,0.6972656,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.6972656,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7184584629053754,0.020880480101791575,0.002658396101019052,,7.854540598290597,0.0,14.0,0.0,1.0,Disordered juxtamembrane tails/linkers,True,assigned_and_evaluated +7110,49061,18.194803,0.87841797,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.87841797,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9408767544702942,0.09374156021738693,0.012405848471422242,,7.556239336094368,0.0,15.0,0.0,1.0,Nudix hydrophobic-acidic DE sensor,True,assigned_and_evaluated +7111,87857,22.211033,0.6088867,Nucleus,keyword,87857,Nucleus,0.6088867,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6133863572376623,0.206353976394954,0.06247230837394772,0.2198581560283688,3.303127125697952,18.0,20.0,5.453140243902439,2.419493338193273e-12,Polar IDR PTM hotspots,True,assigned_and_evaluated +7112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory helices and IDRs,False,no_term_above_threshold +7113,81685,25.191376,0.9707031,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9604492,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9578507795100223,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,19.0,19.0,85.66235632183908,8.858414841848649e-37,Kinase activation-loop motifs,True,assigned_and_evaluated +7114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed extracellular domains,False,no_term_above_threshold +7115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic envelope adaptor/tunnel domains,False,no_term_above_threshold +7116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane segments,False,no_term_above_threshold +7117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic helical tether scaffolds,False,no_term_above_threshold +7118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HINT/intein β-core signature,False,no_term_above_threshold +7119,58239,35.784737,0.7792969,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7792969,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7458615245827696,0.4790087212029779,0.017722640673460344,0.5,27.02806709387803,18.0,18.0,35.851473241130485,3.2784535000502832e-28,Helicase ATPase core activation,True,assigned_and_evaluated +7120,36010,17.558826,0.99365234,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9458008,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,14.0,19.0,375.480881691408,3.142613367564698e-34,Conserved N-terminal hydrolase motif,True,assigned_too_few_test_positives +7121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NDP-sugar nucleotidyltransferase core,False,no_term_above_threshold +7122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic-anchored beta strands,False,no_term_above_threshold +7123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal glycine-rich anion-binding loop,False,no_term_above_threshold +7124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-TM peripheral regulatory domains,False,no_term_above_threshold +7125,87326,18.156376,0.6176758,Coiled coil,keyword,87326,Coiled coil,0.6176758,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.5005208549276504,0.04827481060830779,0.03943287549844927,0.011235955056179775,1.224227500482592,3.0,20.0,1.8911292027912878,0.32855189901648835,Short acidic DE-rich segments,True,assigned_and_evaluated +7126,88009,18.199438,0.62109375,Repeat,keyword,88009,Repeat,0.62109375,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6379263631384522,0.14568544920558577,0.07266282676118742,,2.0049515783963847,14.0,19.0,6.532529837605165,7.391597730719461e-10,Proline-rich disordered tandem repeats,True,assigned_and_evaluated +7127,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chromatin regulatory low-complexity IDRs,False,no_term_above_threshold +7128,36668,18.197042,0.9897461,AMP-dependent synthetase/ligase domain,interpro,64058,NAD(P)-binding domain superfamily,0.7817383,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,1.0,12.0,44.360863095238095,0.037457014335508854,Oxidoreductase active site helix,True,assigned_too_few_test_positives +7129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding helix-loop-strand patches,False,no_term_above_threshold +7130,63831,19.143452,0.9291992,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9291992,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9028950096253517,0.01489372068167992,0.002658396101019052,,5.60252126309193,0.0,18.0,0.0,1.0,Active-site proximal capping loops,True,assigned_and_evaluated +7131,36535,16.9837,0.9165039,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.890625,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9469514908767246,0.5195273151010856,0.004430660168365086,0.9,117.25731501831504,3.0,17.0,15.845411055988661,0.0014669756653790072,Endocytic IDR SLiM platforms,True,assigned_and_evaluated +7132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ORD-centric activation; prokaryotic residue peaks,False,no_term_above_threshold +7133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop-to-beta junction motif,False,no_term_above_threshold +7134,50338,20.214964,0.97265625,"GPCR, rhodopsin-like, 7TM",interpro,87276,Cell membrane,0.6088867,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Cytosolic TM entry segments,True,assigned_too_few_test_positives +7135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular acidic metal-binding scaffold,False,no_term_above_threshold +7136,36668,19.9176,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,18.0,18.0,532.3303571428571,1.2239400872533205e-48,ANL AMP-binding loop,True,assigned_too_few_test_positives +7137,50338,18.501896,0.7553711,"GPCR, rhodopsin-like, 7TM",interpro,87484,G-protein coupled receptor,0.6894531,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Pore-lining TM helices and caps,True,assigned_too_few_test_positives +7138,29116,16.072195,0.7548828,methyltransferase activity,go_mf,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.74121094,62,go,GO:0008168,go_mf:go:GO:0008168,14.0,2257.0,0.7796318705814916,0.2294297450528191,0.006202924235711121,0.5,36.987352470300905,7.0,14.0,108.40181818181817,3.078652209536408e-13,C-terminal substrate recognition lid,True,assigned_and_evaluated +7139,87326,23.548338,0.63183594,Coiled coil,keyword,87326,Coiled coil,0.63183594,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6517424022554832,0.11805878417662427,0.03943287549844927,0.011235955056179775,2.9939177065914717,12.0,18.0,8.40501867907239,1.4878219757400116e-09,Coiled-coil oligomerization segments,True,assigned_and_evaluated +7140,39958,15.8865795,0.8852539,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8852539,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.7231230564193691,0.014653082346803625,0.002658396101019052,,5.5120011427892965,0.0,18.0,0.0,1.0,Coiled-coil helix-face interface,True,assigned_and_evaluated +7141,47529,18.034801,0.7910156,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7910156,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8289128737170905,0.10938732084828555,0.007089056269384138,0.0625,15.430448947161281,11.0,17.0,50.03669794766156,4.4323339171336737e-17,Aromatic beta-strand motifs,True,assigned_and_evaluated +7142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic active-site scaffolds,False,no_term_above_threshold +7143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Q-rich transactivation IDRs,False,no_term_above_threshold +7144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transducing juxtadomain helix,False,no_term_above_threshold +7145,85364,19.751879,0.765625,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.765625,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,ABC SBP clamshell binding cleft,True,assigned_too_few_test_positives +7146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sm/LSM-biased RNA-binding domains,False,no_term_above_threshold +7147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed catalytic-domain loop/helix activations,False,no_term_above_threshold +7148,52236,18.69378,0.99902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99316406,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,18.0,210.8940907199334,9.175234661021449e-39,TPR repeat register detector,True,assigned_too_few_test_positives +7149,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helix-coil caps,False,no_term_above_threshold +7150,88154,30.73565,0.94921875,Transit peptide,keyword,88154,Transit peptide,0.94921875,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.9972757127929541,0.7652378175557991,0.010633584404076208,0.9583333333333334,71.96423975930993,17.0,18.0,27.5752802263576,5.890906220761299e-24,Mitochondrial transit peptide,True,assigned_and_evaluated +7151,63831,16.192873,0.9121094,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9121094,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7769509847475196,0.006483150915913107,0.002658396101019052,,2.43874526953598,0.0,14.0,0.0,1.0,N-terminal amphipathic helix start,True,assigned_and_evaluated +7152,87697,22.62406,0.90966797,Knottin,keyword,87697,Knottin,0.90966797,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.895840558599801,0.07312711336419181,0.017279574656623838,,4.231997304178997,0.0,17.0,0.0,1.0,RNase A catalytic His motif,True,assigned_and_evaluated +7153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site–flanking segments,False,no_term_above_threshold +7154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-protein folded-disordered boundary activation,False,no_term_above_threshold +7155,37894,17.22197,0.93603516,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8466797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,Rossmann active-site gating loops,True,assigned_too_few_test_positives +7156,49061,15.578693,0.84814453,WD40/YVTN repeat-like-containing domain superfamily,interpro,87413,Disulfide bond,0.6533203,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.852784720887009,0.03993686136299186,0.012405848471422242,,3.219196289152594,0.0,18.0,0.0,1.0,Beta-strand connecting loops,True,assigned_and_evaluated +7157,36091,31.271633,0.9995117,GNAT domain,interpro,85712,3.40.630.30,0.99121094,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,20.0,0.0,1.0,GHKL ATP-lid G1 loop,True,assigned_too_few_test_positives +7158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isoprenoid helical catalytic core,False,no_term_above_threshold +7159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich NTP-binding loops,False,no_term_above_threshold +7160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BAH and reader domain cores,False,no_term_above_threshold +7161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peri-cofactor flexible linkers,False,no_term_above_threshold +7162,81858,19.255726,0.95703125,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.95703125,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,1.0,17.0,15.382094943240453,0.1032378735730138,ICL1 TM1–TM2 junction motif,True,assigned_too_few_test_positives +7163,64148,27.56982,0.87890625,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.84277344,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8254315413197874,0.27065477593950416,0.008418254319893664,0.21052631578947367,32.15093838397163,0.0,17.0,0.0,1.0,HTH helix N-cap detector,True,assigned_and_evaluated +7164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hinge/cap segments near active sites,False,no_term_above_threshold +7165,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered mixed-charge RNA-binding tails,False,no_term_above_threshold +7166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted CAZyme catalytic domains,False,no_term_above_threshold +7167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,dDENN domain marker,False,no_term_above_threshold +7168,85364,21.905993,0.98535156,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.98535156,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,N-terminal coil-to-beta boundary,True,assigned_too_few_test_positives +7169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT/RdRp A/B palm/fingers neighborhood,False,no_term_above_threshold +7170,47529,31.908321,0.96484375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.96484375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9956492637215528,0.6437739603857112,0.007089056269384138,0.875,90.81236428690939,14.0,18.0,60.14512177547197,2.7100217262699095e-23,Beta-sandwich domain junctions,True,assigned_and_evaluated +7171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active-site lids,False,no_term_above_threshold +7172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptide C-region linker,False,no_term_above_threshold +7173,87850,16.40517,0.7841797,Nuclease,keyword,87601,Hydrolase,0.65625,223,keywords,Nuclease,keyword:keywords:Nuclease,66.0,2257.0,0.8911455956184392,0.12903692342724052,0.02924235711120957,0.015151515151515152,4.412671760231543,11.0,11.0,61.71946169772257,4.961918520686405e-20,Mg2+-carboxylate active-site flanks,True,assigned_and_evaluated +7174,85762,27.761225,0.9140625,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9082031,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,18.0,205.58965517241379,1.4365296813653038e-41,Flavin pocket adjacent helix,True,assigned_too_few_test_positives +7175,63951,19.78832,0.8886719,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.78271484,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8840450771055752,0.3869972431447842,0.003987594151528578,0.5555555555555556,97.05030864197532,4.0,17.0,37.9147853736089,6.16161471053209e-06,Extracellular FnIII activation gradient,True,assigned_and_evaluated +7176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HATPase_c CA with RR spillover,False,no_term_above_threshold +7177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic flanking regions,False,no_term_above_threshold +7178,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature-domain aromatic-acidic cores,False,no_term_above_threshold +7179,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Dynamin-family coiled-coil stalks,False,no_term_above_threshold +7180,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Vicilin first cupin detector,False,no_term_above_threshold +7181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cap/lid activation,False,no_term_above_threshold +7182,63951,20.501772,0.90771484,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.8486328,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9383402530644522,0.2737404811620777,0.003987594151528578,,68.6480295536455,0.0,14.0,0.0,1.0,Extracellular beta-sandwich strands,True,assigned_and_evaluated +7183,85762,34.82131,0.9116211,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.89941406,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,16.0,205.58965517241379,4.0182436921199225e-37,Flavin-proximal gating loop,True,assigned_too_few_test_positives +7184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic repeat scaffold surfaces,False,no_term_above_threshold +7185,36449,18.743008,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,14.0,18.0,828.0694444444445,1.7040205089002093e-39,Transmembrane helix entry segments,True,assigned_too_few_test_positives +7186,88058,38.25883,0.67626953,Signal,keyword,88058,Signal,0.67626953,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6417861521493186,0.21842239263303376,0.09127159946832078,0.1941747572815534,2.3931035930716367,13.0,16.0,5.854025679758308,5.314231671335989e-09,Mature secreted helical scaffolds,True,assigned_and_evaluated +7187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed polar loops and N-caps,False,no_term_above_threshold +7188,50806,17.667131,0.80615234,"Homeobox, conserved site",interpro,37071,Homeodomain,0.73828125,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,9.0,0.0,1.0,Basic amphipathic linker helix,True,assigned_too_few_test_positives +7189,36535,20.91754,0.9873047,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8769531,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9953938584779707,0.5480194805194806,0.004430660168365086,0.9,123.68799675324678,0.0,18.0,0.0,1.0,HATPase_c F-box beta-strand hydrophobe,True,assigned_and_evaluated +7190,82029,25.259804,0.96972656,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9638672,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,17.0,188.0788643533123,1.0133225259294918e-38,Extracellular loops of SLC/MFS transporters,True,assigned_too_few_test_positives +7191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase catalytic core,False,no_term_above_threshold +7192,24917,17.260328,0.60839844,nucleus,go_cc,24917,nucleus,0.60839844,1728,go,GO:0005634,go_cc:go:GO:0005634,132.0,2257.0,0.6588930481283423,0.22091062887029644,0.05848471422241914,0.12121212121212122,3.7772370406080236,14.0,15.0,5.338795612267742,6.450746450247735e-10,Chromatin/DNA recognition domains,True,assigned_and_evaluated +7193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early TM/juxtamembrane activation,False,no_term_above_threshold +7194,47717,15.9960985,0.9970703,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8798828,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,14.0,273.49082568807336,2.439567240558689e-34,Walker A-adjacent helicase helix,True,assigned_too_few_test_positives +7195,46078,17.10049,0.9194336,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9145508,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,11.0,19.0,75.69609879963066,8.357292771407628e-19,HEAT-repeat α-solenoid scaffolds,True,assigned_too_few_test_positives +7196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping scaffold,False,no_term_above_threshold +7197,85364,29.298841,0.96777344,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.96777344,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,15.0,16.0,282.29640151515156,3.4498713320022935e-36,Transferrin interlobe connecting helix,True,assigned_too_few_test_positives +7198,28225,15.822499,0.71435547,metalloendopeptidase activity,go_mf,4761,3.4.24.-,0.69189453,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,4.0,17.0,71.57382953181273,5.079072160618275e-07,Pan-zinc metallopeptidase signature,True,assigned_too_few_test_positives +7199,64058,25.71986,0.91308594,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9086914,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9910356028278453,0.8034175279307125,0.006202924235711121,0.7857142857142857,129.522382895687,14.0,14.0,113.99808795411089,4.8145062114693447e-29,SDR YXXXK catalytic microenvironment,True,assigned_and_evaluated +7200,37894,17.533579,0.7080078,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7080078,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,14.0,0.0,1.0,Secretory N-terminal segments,True,assigned_too_few_test_positives +7201,81685,22.482046,0.9633789,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.95703125,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9524127691165554,0.4625150490447019,0.005316792202038104,0.9166666666666666,86.99137214115768,0.0,18.0,0.0,1.0,Allosteric pocket-facing helix,True,assigned_and_evaluated +7202,37071,20.195045,0.9682617,Homeodomain,interpro,43624,Homedomain-like superfamily,0.8105469,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,1.0,19.0,10.857949371699142,0.14324046356083628,Helical chromatin recognition domains,True,assigned_too_few_test_positives +7203,88161,21.688663,0.6147461,Transmembrane helix,keyword,88161,Transmembrane helix,0.6147461,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7056954436450839,0.4041392717429615,0.1847585290208241,0.21103117505995203,2.187391693822216,9.0,17.0,2.8733781359608024,0.0024598957462889687,Helix-loop boundary signal,True,assigned_and_evaluated +7204,64058,21.4694,0.9291992,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.91552734,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9463728424941087,0.31168919340404333,0.006202924235711121,0.07142857142857142,50.2487506794947,2.0,15.0,15.199745060548118,0.012797213476436363,Helix N-cap transition motifs,True,assigned_and_evaluated +7205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active-site residue,False,no_term_above_threshold +7206,84152,26.310467,0.9555664,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9555664,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,15.0,15.0,562.4622641509434,2.0575595524537636e-41,Metal proximal gating segment,True,assigned_too_few_test_positives +7207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered tails in short proteins,False,no_term_above_threshold +7208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble extramembrane regulatory segments,False,no_term_above_threshold +7209,84152,18.030416,0.79248047,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.79248047,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,7.0,14.0,281.2311320754717,3.7318869949465777e-16,Metal-binding catalytic cores,True,assigned_too_few_test_positives +7210,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble extracytoplasmic alpha-helix,False,no_term_above_threshold +7211,82608,18.221746,0.7421875,Ankyrin repeat-containing domain,gene3d,82608,Ankyrin repeat-containing domain,0.7421875,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.730658070253446,0.022886529746829108,0.003544528134692069,,6.456862204824162,0.0,16.0,0.0,1.0,Disordered N-termini of metalloproteases,True,assigned_and_evaluated +7212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular appendage stalks and boundaries,False,no_term_above_threshold +7213,36876,16.396233,0.9995117,Cytochrome P450,interpro,37007,Metallo-beta-lactamase,0.90722656,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,19.0,19.0,389.6797385620915,1.1914170695636868e-48,P450 C-terminal meander region,True,assigned_and_evaluated +7214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining TM helix-boundary motif,False,no_term_above_threshold +7215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active site capping,False,no_term_above_threshold +7216,88058,20.218985,0.6201172,Signal,keyword,88058,Signal,0.6201172,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6107203211315341,0.10354665364967194,0.09127159946832078,,1.1344893072199493,7.0,17.0,2.966746045850364,0.009210270678245402,Mucin-like low-complexity repeats,True,assigned_and_evaluated +7217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter TM helix-loop junctions,False,no_term_above_threshold +7218,37690,22.43993,0.8515625,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.82958984,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.770126984126984,0.3298627334805967,0.0031014621178555605,0.2857142857142857,106.35716992367239,2.0,17.0,21.25525846702317,0.006778920871199917,C-terminal PTM-rich IDR tails,True,assigned_and_evaluated +7219,81685,22.7995,0.9892578,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.97998047,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9966963622865627,0.9265676567656765,0.005316792202038104,0.9166666666666666,174.27193344334432,14.0,14.0,85.66235632183908,2.52616524771724e-27,Kinase domain beta-strand residues,True,assigned_and_evaluated +7220,48880,19.122467,0.86083984,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.86083984,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,6.0,16.0,181.77134146341461,1.185160338518028e-12,N-terminal cofactor-pocket glycine-rich loop-helix,True,assigned_too_few_test_positives +7221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Contiguous helical/IDR regions,False,no_term_above_threshold +7222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity disordered linkers,False,no_term_above_threshold +7223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal catalytic substrate-binding segments,False,no_term_above_threshold +7224,64058,21.791937,0.66748047,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.65625,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6401184637921151,0.2377639935016984,0.006202924235711121,0.21428571428571427,38.33095238095238,15.0,15.0,113.99808795411089,4.589611073054062e-31,NAD(P)-site Rossmann loop,True,assigned_and_evaluated +7225,85656,16.917213,0.88916016,alpha/beta hydrolase,gene3d,88153,Transferase,0.6640625,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9053015873015874,0.018413177663129575,0.0031014621178555605,,5.93693456938335,3.0,14.0,30.274712254570073,0.00021994663587455714,Enzyme alpha-helical core detector,True,assigned_and_evaluated +7226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix start anchors,False,no_term_above_threshold +7227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cleft wall segment,False,no_term_above_threshold +7228,87317,22.468493,0.87353516,Cleavage on pair of basic residues,keyword,88058,Signal,0.640625,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9549308344489068,0.5347324347989787,0.007089056269384138,0.4375,75.43069408383093,13.0,17.0,64.57865355774037,5.034618240458993e-22,Secreted short-peptide prohormones,True,assigned_and_evaluated +7229,36499,24.125746,0.8642578,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.8642578,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,18.0,0.0,1.0,Polysaccharide binding cleft exosites,True,assigned_too_few_test_positives +7230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfatase-CAZy hydrolase cores,False,no_term_above_threshold +7231,55054,27.605722,1.0,HAD superfamily,interpro,55054,HAD superfamily,1.0,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8984014209591475,0.8004430660168365,0.002215330084182543,0.8,361.32,17.0,17.0,334.9494382022472,7.26757959387553e-43,Phosphatase cap/lid substrate-recognition loop,True,assigned_and_evaluated +7232,36091,25.527267,0.9819336,GNAT domain,interpro,85712,3.40.630.30,0.9213867,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,GHKL ATPase nucleotide-binding loop,True,assigned_too_few_test_positives +7233,36535,20.827587,0.9560547,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.93066406,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.936359590565198,0.3946911649840366,0.004430660168365086,0.7,89.08179593689707,0.0,6.0,0.0,1.0,Acidic helix-loop micro-motifs,True,assigned_and_evaluated +7234,59224,25.539661,0.96972656,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.96972656,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9997460317460317,0.948051948051948,0.0031014621178555605,1.0,305.6790352504638,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Hydrolase core β-strand anchors,True,assigned_and_evaluated +7235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrophobic packing anchor,False,no_term_above_threshold +7236,82029,19.278143,0.92333984,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6611328,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,3.0,18.0,31.346477392218716,0.00020838843291859314,Short disordered terminal tails,True,assigned_too_few_test_positives +7237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Macromolecule-binding domain cores,False,no_term_above_threshold +7238,88058,95.68806,0.91748047,Signal,keyword,88058,Signal,0.91748047,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9263548920015338,0.6949937090802502,0.09127159946832078,0.883495145631068,7.614566997058858,20.0,20.0,7.204954682779456,1.6966660215964757e-17,Bacterial secretory signal peptides,True,assigned_and_evaluated +7239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid and coiled-coil scaffolds,False,no_term_above_threshold +7240,85364,24.463717,0.85253906,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.85253906,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,SBP C-lobe ligand pocket,True,assigned_too_few_test_positives +7241,81685,16.380638,0.94921875,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.87890625,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9961024498886415,0.8907532592950267,0.005316792202038104,0.9166666666666666,167.5358421857396,20.0,20.0,85.66235632183908,1.209373710987114e-38,Kinase C-lobe acidic helix,True,assigned_and_evaluated +7242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cleft-lining catalytic loops,False,no_term_above_threshold +7243,27932,33.853607,0.7890625,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.75683594,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.7785143573101098,0.49056970599934646,0.01949490474080638,0.5454545454545454,25.16399605546648,11.0,11.0,103.50868055555556,1.7269677158621563e-22,uL4 core motif hotspot,True,assigned_and_evaluated +7244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like donor-binding pockets,False,no_term_above_threshold +7245,87326,37.17434,0.7939453,Coiled coil,keyword,87326,Coiled coil,0.7939453,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8091157386292965,0.2588592396658831,0.03943287549844927,0.06741573033707865,6.564553976695485,7.0,15.0,5.883513075350673,0.00013074948662003565,Leucine-rich coiled-coil helices,True,assigned_and_evaluated +7246,63831,16.135426,0.89697266,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.89697266,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.808751665926255,0.007599814176944864,0.002658396101019052,,2.8587967662274263,0.0,18.0,0.0,1.0,Helix–strand linkers near active sites,True,assigned_and_evaluated +7247,85664,21.44805,0.9790039,Glycogen Phosphorylase B;,gene3d,36776,SANT/Myb domain,0.9267578,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,20.0,20.0,331.22777777777776,1.2127040143295405e-49,Glycosyltransferase donor-helix hydrophobic hotspot,True,assigned_too_few_test_positives +7248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BRCT-flanking disordered C-termini,False,no_term_above_threshold +7249,59224,17.948242,0.8852539,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.87402344,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9386666666666668,0.029369258969664244,0.0031014621178555605,,9.469488213504599,0.0,16.0,0.0,1.0,GTPase G4 proximal beta-strands,True,assigned_and_evaluated +7250,38317,21.4473,1.0,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.92871094,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,20.0,20.0,384.6516129032258,7.999014609586429e-51,C-terminal helix-B packing,True,assigned_and_evaluated +7251,58239,19.941717,0.640625,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.640625,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6468933243121335,0.1906069794006533,0.017722640673460344,0.15,10.754998812681864,20.0,20.0,35.851473241130485,2.9591156525725853e-31,Amphipathic domain-onset capping helix,True,assigned_and_evaluated +7252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-lactamase fold C-terminus,False,no_term_above_threshold +7253,85656,18.92615,0.96435547,alpha/beta hydrolase,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.84033203,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9543809523809523,0.0378500528863375,0.0031014621178555605,,12.203938480637676,1.0,15.0,9.418799368088466,0.16347652490170986,Helix-strand linker loops,True,assigned_and_evaluated +7254,50779,17.945843,0.9550781,Myb domain,interpro,80926,Homeodomain-like,0.9013672,33,ip,IPR017930,interpro:ip:IPR017930,5.0,2257.0,0.9791296625222026,0.058510843653700795,0.002215330084182543,,26.41179482528054,0.0,18.0,0.0,1.0,HTH recognition helix residues,True,assigned_and_evaluated +7255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC intracellular coupling helices,False,no_term_above_threshold +7256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S9 peptidase surface loops,False,no_term_above_threshold +7257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered helical enzyme cores,False,no_term_above_threshold +7258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane flanking low complexity IDRs,False,no_term_above_threshold +7259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal beta-strand activation,False,no_term_above_threshold +7260,17191,16.245932,0.70703125,transmembrane transport,go_bp,17191,transmembrane transport,0.70703125,83,go,GO:0055085,go_bp:go:GO:0055085,5.0,2257.0,0.6962699822380107,0.2248586098152154,0.002215330084182543,0.2,101.50117647058825,5.0,11.0,68.26310968628349,1.155084952308963e-08,PG-kinked mid-late transmembrane helix,True,assigned_and_evaluated +7261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-strand cores,False,no_term_above_threshold +7262,87317,18.265196,0.8300781,Cleavage on pair of basic residues,keyword,88058,Signal,0.8125,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9103357875948237,0.14827936232409764,0.007089056269384138,,20.916657547843023,2.0,18.0,9.383223166509286,0.031865022652522924,N-terminal signal peptide,True,assigned_and_evaluated +7263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tails,False,no_term_above_threshold +7264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal eukaryote domain-core detector,False,no_term_above_threshold +7265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal initiator Met recognition,False,no_term_above_threshold +7266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered targeting/linker segments,False,no_term_above_threshold +7267,4066,24.266039,0.9165039,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9165039,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7975133214920072,0.6008861320336729,0.002215330084182543,0.6,271.23999999999995,9.0,20.0,323.2463855421687,5.552391713134692e-21,Broad nuclease-domain helical activation,True,assigned_and_evaluated +7268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity motifs,False,no_term_above_threshold +7269,49116,23.785654,0.8852539,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8852539,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9992007104795737,0.5961904761904762,0.002215330084182543,1.0,269.12038095238097,16.0,18.0,77.36707218167072,4.170212708294483e-29,Alpha-solenoid repeat scaffolds,True,assigned_and_evaluated +7270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory lumenal-domain N-terminus hotspot,False,no_term_above_threshold +7271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich cytoplasmic IDRs,False,no_term_above_threshold +7272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix C-terminal capping motif,False,no_term_above_threshold +7273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic helical patches,False,no_term_above_threshold +7274,36876,17.753323,1.0,Cytochrome P450,interpro,36876,Cytochrome P450,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,16.0,16.0,389.6797385620915,1.6482263221307779e-41,Cytochrome P450 I-helix,True,assigned_and_evaluated +7275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Duplex nucleic acid-binding interfaces,False,no_term_above_threshold +7276,69819,26.545034,0.8935547,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8691406,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,15.0,15.0,419.86619718309856,1.6608451341010338e-39,Early-domain phosphate/metal-binding elements,True,assigned_too_few_test_positives +7277,36668,15.6996355,0.94189453,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.89453125,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,17.0,0.0,1.0,PAC capping beta-strand,True,assigned_too_few_test_positives +7278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed beta-alpha junction hinges,False,no_term_above_threshold +7279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic S/T low-complexity regions,False,no_term_above_threshold +7280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent catalytic cores,False,no_term_above_threshold +7281,36409,17.66591,0.9921875,"Zinc finger, CCCH-type",interpro,87697,Knottin,0.8989258,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,13.0,0.0,1.0,Hexapeptide-repeat beta-helix turns,True,assigned_too_few_test_positives +7282,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C TM helix N-termini,False,no_term_above_threshold +7283,30856,17.068182,0.84228516,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.7685547,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7974245115452931,0.008327826122779642,0.002215330084182543,,3.7591807118227307,0.0,14.0,0.0,1.0,TM helix caps and kinks,True,assigned_and_evaluated +7284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/aromatic strand-coil transition motifs,False,no_term_above_threshold +7285,38873,16.6501,0.8935547,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8364258,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7912966252220249,0.16199724314478411,0.002215330084182543,,73.12555555555555,2.0,20.0,17.13247126436782,0.010335862878412818,P-loop NTPase coupling helix,True,assigned_and_evaluated +7286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Near-global, disorder-biased activation",False,no_term_above_threshold +7287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helical/IDR interaction patches,False,no_term_above_threshold +7288,85672,20.045618,0.6254883,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61865234,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6344239331632398,0.22051907054579906,0.01595037660611431,0.25,13.825320617274125,11.0,16.0,27.509689597315436,2.0610292200399165e-14,Acidic Mg2+-coordinating nuclease domains,True,assigned_and_evaluated +7289,47529,19.356333,0.9248047,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9248047,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9348505131637661,0.35475248872436144,0.007089056269384138,0.5,50.042272940680235,17.0,18.0,73.03336215593025,4.719214826677225e-31,Solvent exposed ectodomain loops,True,assigned_and_evaluated +7290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic helical cores,False,no_term_above_threshold +7291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline glycine charged hinge linker,False,no_term_above_threshold +7292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich oxoanion-binding loops,False,no_term_above_threshold +7293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal coiled-coil sensors/tethers,False,no_term_above_threshold +7294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-termini and C-terminal helices,False,no_term_above_threshold +7295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader/linker segments,False,no_term_above_threshold +7296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bromodomains and flanking IDRs,False,no_term_above_threshold +7297,85649,26.59943,0.95703125,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.95458984,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9618056907088085,0.38580446136700947,0.0101905183872397,0.34782608695652173,37.8591595350148,0.0,13.0,0.0,1.0,Rossmann cofactor-binding loops,True,assigned_and_evaluated +7298,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDR scaffolds,False,no_term_above_threshold +7299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane sensor domains,False,no_term_above_threshold +7300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PA14 carbohydrate-binding domain,False,no_term_above_threshold +7301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,cDENN/nSMase3 conserved motif,False,no_term_above_threshold +7302,87852,16.813055,0.90771484,Nucleosome core,keyword,87857,Nucleus,0.6723633,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,20.0,0.0,1.0,Polybasic disordered C-terminal tails,True,assigned_too_few_test_positives +7303,39971,29.830715,1.0,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,16.0,17.0,623.4875816993464,5.26194117401153e-44,Metallophosphoesterase catalytic core,True,assigned_too_few_test_positives +7304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral helical functional regions,False,no_term_above_threshold +7305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding beta-sheet surfaces,False,no_term_above_threshold +7306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical interaction segments,False,no_term_above_threshold +7307,87317,18.03743,0.62402344,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.62402344,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.584518630075859,0.030225894633440435,0.007089056269384138,,4.263740261729692,0.0,10.0,0.0,1.0,Non-collagenous extracellular modules,True,assigned_and_evaluated +7308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted ectodomain N-termini,False,no_term_above_threshold +7309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase ATP-lid hinge,False,no_term_above_threshold +7310,87276,27.944876,0.6040039,Cell membrane,keyword,87276,Cell membrane,0.6040039,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6714746199648068,0.3817670297694003,0.11120957022596367,0.36254980079681276,3.432861299559906,17.0,18.0,7.749617701929841,1.050934808049714e-14,Disordered non-transmembrane loops/tails,True,assigned_and_evaluated +7311,87108,17.02345,0.8256836,ANK repeat,keyword,88009,Repeat,0.6166992,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8429221035982601,0.028589797216254757,0.003987594151528578,,7.169685813009665,6.0,18.0,56.459280303030305,1.4671601699082337e-09,Single-repeat acidic S/T hotspot,True,assigned_and_evaluated +7312,36354,20.198168,0.82373047,RNA recognition motif domain,interpro,36354,RNA recognition motif domain,0.82373047,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,12.0,0.0,1.0,ABC NBD post-Walker A loop,True,assigned_too_few_test_positives +7313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane catalytic loops,False,no_term_above_threshold +7314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protein C-terminal extension,False,no_term_above_threshold +7315,37341,24.499634,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9951172,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,16.0,16.0,145.4170731707317,9.378114214926556e-35,WD40 blade D-strand hydrophobe,True,assigned_and_evaluated +7316,43624,16.83104,0.8232422,Homedomain-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8173828,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8727549085229807,0.036776521544103144,0.007089056269384138,,5.18778807031505,0.0,17.0,0.0,1.0,Molybdopterin binding Asn motif,True,assigned_and_evaluated +7317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxyanion/metal-binding edge motif,False,no_term_above_threshold +7318,85672,23.692392,0.6455078,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6425781,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6225924258342088,0.2267059482394182,0.01595037660611431,0.25,14.213203477121302,17.0,17.0,40.01409395973155,1.7557395315514075e-27,RecA motor coupling interface,True,assigned_and_evaluated +7319,58239,30.079762,0.8095703,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8095703,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7559088858818223,0.1719367548372879,0.017722640673460344,0.1,9.70153139169397,9.0,9.0,35.851473241130485,2.309016775409654e-14,AAA+ ATPase active site,True,assigned_and_evaluated +7320,87276,27.426786,0.60302734,Cell membrane,keyword,87276,Cell membrane,0.60302734,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7155793575448952,0.44994637980916136,0.11120957022596367,0.46215139442231074,4.045932188164451,12.0,16.0,6.154108175061933,2.4137614889979377e-08,Juxtamembrane helix-loop transitions,True,assigned_and_evaluated +7321,45288,15.748805,0.9814453,CheY-like superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6455078,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,13.0,13.0,462.17829457364337,6.281107742864664e-35,REC α4–β5–α5 output surface,True,assigned_too_few_test_positives +7322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intein inserts and junction linkers,False,no_term_above_threshold +7323,38873,17.198393,0.8413086,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.72314453,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8959147424511545,0.48977112925794325,0.002215330084182543,0.4,221.0826877470356,9.0,9.0,171.32471264367817,1.8650004750458193e-20,AAA+ mechanochemical coupling loops,True,assigned_and_evaluated +7324,85649,19.95097,0.96533203,Vaccinia Virus protein VP39,gene3d,87413,Disulfide bond,0.63720703,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9528726013000662,0.8283846789641145,0.0101905183872397,0.8695652173913043,81.28974871400027,15.0,17.0,97.60067663429007,8.553173227289025e-29,MTase core beta-strand motif,True,assigned_and_evaluated +7325,36104,17.601141,0.85058594,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.85058594,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,12.0,0.0,1.0,NBD Thr/Ser and XGG peaks,True,assigned_too_few_test_positives +7326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured catalytic/binding domain cores,False,no_term_above_threshold +7327,36499,16.99551,0.99609375,"Zinc finger, GATA-type",interpro,88150,Transcription regulation,0.6191406,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,9.0,18.0,382.1858974358974,9.142256777820621e-22,N-terminal TF activation IDR,True,assigned_too_few_test_positives +7328,24917,15.850227,0.61621094,nucleus,go_cc,24917,nucleus,0.61621094,1728,go,GO:0005634,go_cc:go:GO:0005634,132.0,2257.0,0.7310909090909091,0.15026849044878154,0.05848471422241914,,2.5693635071431813,4.0,20.0,1.1440276312002302,0.7352924798924473,Proline-rich disordered regions,True,assigned_and_evaluated +7329,38317,23.296944,1.0,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.8149414,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9999365079365079,0.982142857142857,0.0031014621178555605,1.0,316.67091836734687,11.0,11.0,384.6516129032258,8.972063948750959e-29,PPR alpha-solenoid repeat detector,True,assigned_and_evaluated +7330,37894,18.526964,0.9770508,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.78515625,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,12.0,650.625992063492,1.0290217778680566e-30,SDR C-terminal helix-loop cap,True,assigned_too_few_test_positives +7331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible phosphate-binding lid loop,False,no_term_above_threshold +7332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIM-barrel active-site loops,False,no_term_above_threshold +7333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered amphipathic helical scaffolds,False,no_term_above_threshold +7334,69819,29.067112,0.8691406,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.86035156,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,Phosphate-binding loop-helix motif,True,assigned_too_few_test_positives +7335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain boundary entry segment,False,no_term_above_threshold +7336,36886,24.375284,0.9921875,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9921875,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9975544686527346,0.739750110570544,0.003544528134692069,0.75,208.70199994471471,0.0,14.0,0.0,1.0,Disordered transcriptional activation domains,True,assigned_and_evaluated +7337,25167,16.573952,0.7573242,cell outer membrane,go_cc,25167,cell outer membrane,0.7573242,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9993318485523386,0.9106799450549451,0.005316792202038104,1.0,171.2837196657509,15.0,19.0,107.70986390461279,9.862136519376656e-29,Outer-membrane beta-barrel detector,True,assigned_and_evaluated +7338,27918,16.547663,0.7558594,DNA-binding transcription factor activity,go_mf,87384,DNA-binding,0.71875,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.7632464434790016,0.02249307716452737,0.00930438635356668,,2.4174702457303945,1.0,20.0,1.8504345127250157,0.657326388704493,Amphipathic coiled-coil helices,True,assigned_and_evaluated +7339,37020,19.085167,0.9921875,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9711914,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,11.0,14.0,641.7133072407045,5.7348770664232806e-30,Leloir glycosyltransferase Rossmann core,True,assigned_too_few_test_positives +7340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-strand scaffolds,False,no_term_above_threshold +7341,85656,20.213924,0.9628906,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.9604492,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9879365079365079,0.3526733083961999,0.0031014621178555605,0.2857142857142857,113.71195100717475,7.0,16.0,61.810870853080566,1.9768001144209375e-11,Pocket-rim gating loops,True,assigned_and_evaluated +7342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp ATP-binding core,False,no_term_above_threshold +7343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal coiled-coil arms,False,no_term_above_threshold +7344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich SH3-binding IDR linkers,False,no_term_above_threshold +7345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-TM soluble catalytic segment,False,no_term_above_threshold +7346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,End-of-domain nucleic acid segments,False,no_term_above_threshold +7347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal post-catalytic charged segment,False,no_term_above_threshold +7348,87882,23.624134,0.8881836,Palmitate,keyword,87413,Disulfide bond,0.8769531,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8125647860210278,0.008006722210401902,0.002658396101019052,,3.0118620048128486,0.0,20.0,0.0,1.0,Secreted cysteine-crosslinked peptide detector,True,assigned_and_evaluated +7349,25167,16.097538,0.7163086,cell outer membrane,go_cc,25167,cell outer membrane,0.7163086,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9512620638455827,0.6164117809438848,0.005316792202038104,0.75,115.93678246586234,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel signature,True,assigned_and_evaluated +7350,88164,16.445868,0.71435547,Transposition,keyword,88164,Transposition,0.71435547,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.5960923623445826,0.20177226406734605,0.002215330084182543,0.2,91.08000000000001,1.0,20.0,36.35426829268293,0.04534455087147504,Nucleic acid recognition interfaces,True,assigned_and_evaluated +7351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His-motif nucleotide-binding helix,False,no_term_above_threshold +7352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-cytosolic juxtamembrane loops,False,no_term_above_threshold +7353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEP carboxyvinyltransferase core motifs,False,no_term_above_threshold +7354,49121,21.62836,0.97558594,"Signal transduction response regulator, C-terminal effector",interpro,37071,Homeodomain,0.6904297,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,18.0,18.0,977.3934426229509,3.323848884808655e-53,HTH/homeodomain DNA-binding core,True,assigned_too_few_test_positives +7355,49045,18.37454,0.9916992,Kelch-type beta propeller,interpro,49045,Kelch-type beta propeller,0.9916992,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,1.0,16.0,33.87556818181818,0.048544491786459844,Beta-propeller blade strand positions,True,assigned_too_few_test_positives +7356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC juxtamembrane loop-helix connectors,False,no_term_above_threshold +7357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered calmodulin-binding IQ tails,False,no_term_above_threshold +7358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase CA loop-beta junction,False,no_term_above_threshold +7359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA/RNA-binding interface residues,False,no_term_above_threshold +7360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-decorated low-complexity regulatory IDRs,False,no_term_above_threshold +7361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MLO 7TM/Type II signal-anchor,False,no_term_above_threshold +7362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich regulatory linkers,False,no_term_above_threshold +7363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topoisomerase phosphate-chemistry cores,False,no_term_above_threshold +7364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic cNMP regulatory regions,False,no_term_above_threshold +7365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic aromatic nucleic-acid binding surfaces,False,no_term_above_threshold +7366,31094,17.030561,0.9707031,phosphopantetheine binding,go_mf,36668,AMP-dependent synthetase/ligase domain,0.88964844,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.998931909212283,0.8883116883116883,0.004430660168365086,0.8,200.49194805194807,0.0,14.0,0.0,1.0,C-terminal AS hydrophobic microdomain,True,assigned_and_evaluated +7367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory N-terminal active site loop,False,no_term_above_threshold +7368,31094,16.203178,0.99658203,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.6352539,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9998219848687138,0.9651515151515152,0.004430660168365086,1.0,217.834696969697,12.0,17.0,501.0168067226891,6.572614919926578e-31,Helical G/S/A-rich acyl-enzyme segments,True,assigned_and_evaluated +7369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helical nucleic acid interfaces,False,no_term_above_threshold +7370,88158,16.192633,0.70458984,Translocation,keyword,88158,Translocation,0.70458984,68,keywords,Translocation,keyword:keywords:Translocation,18.0,2257.0,0.49464046449307725,0.007975188303057155,0.007975188303057155,,1.0,9.0,17.0,97.41993464052288,2.0768806168658344e-16,Acidic IDRs and Asp hotspots,True,assigned_and_evaluated +7371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cobalamin-processing enzymes and ATCase regulator,False,no_term_above_threshold +7372,59224,17.582848,0.9321289,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9321289,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9611746031746031,0.05317726251484439,0.0031014621178555605,,17.1458687851434,1.0,17.0,8.080916237462727,0.1879739444796349,Helix capping transition sites,True,assigned_and_evaluated +7373,84152,17.588886,0.76416016,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.76416016,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,Amidohydrolase N-terminal β-strands,True,assigned_too_few_test_positives +7374,45804,25.271738,0.9838867,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.95996094,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,18.0,18.0,276.02314814814815,9.166178856014388e-44,MFS TM5–TM6 hairpin,True,assigned_too_few_test_positives +7375,38873,20.402727,0.9765625,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.93359375,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9968916518650088,0.6815734989648032,0.002215330084182543,0.6,307.6622774327122,9.0,9.0,171.32471264367817,1.8650004750458193e-20,ABC P-loop terminal Ser/Thr,True,assigned_and_evaluated +7376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic pre/pro regions,False,no_term_above_threshold +7377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic scaffold IDR tails,False,no_term_above_threshold +7378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase active site,False,no_term_above_threshold +7379,85672,18.621876,0.73828125,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7319336,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8238843864125269,0.052269297304181866,0.01595037660611431,,3.27699455598718,1.0,13.0,3.0780072276716575,0.43998048794038674,Active-site cap segments,True,assigned_and_evaluated +7380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-sheet and TM hydrophobic segments,False,no_term_above_threshold +7381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal alpha-helical surface patches,False,no_term_above_threshold +7382,50869,18.693514,1.0,"DNA binding HTH domain, AraC-type",interpro,80926,Homeodomain-like,0.66552734,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,19.0,19.0,917.2461538461538,1.6344645258281847e-55,Terminal HTH DNA-binding modules,True,assigned_too_few_test_positives +7383,64058,22.354595,0.70703125,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6879883,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6748773963441819,0.2381145782785127,0.006202924235711121,0.21428571428571427,38.387471655328795,15.0,15.0,113.99808795411089,4.589611073054062e-31,Cofactor pocket β-loop-α motif,True,assigned_and_evaluated +7384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leucine-biased disordered hydrophobic segments,False,no_term_above_threshold +7385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory N-terminal microtubule IDRs,False,no_term_above_threshold +7386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal noncatalytic modules,False,no_term_above_threshold +7387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD RPED motif,False,no_term_above_threshold +7388,28962,16.544296,0.68408203,oxygen carrier activity,go_mf,28962,oxygen carrier activity,0.68408203,51,go,GO:0005344,go_mf:go:GO:0005344,,,,,,,,0.0,20.0,0.0,1.0,Amphipathic helical interface patches,True,assigned_too_few_test_positives +7389,38317,16.811346,0.93603516,Pentatricopeptide repeat,interpro,87925,Plant defense,0.7763672,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9826666666666667,0.08742528823284698,0.0031014621178555605,,28.188410791647946,0.0,19.0,0.0,1.0,Plant coiled-coil/disorder and signal-peptide detector,True,assigned_and_evaluated +7390,37894,21.60956,0.95996094,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.74658203,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,12.0,650.625992063492,1.0290217778680566e-30,SDR C-terminal tail activation,True,assigned_too_few_test_positives +7391,50869,19.143957,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.69677734,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,19.0,19.0,917.2461538461538,1.6344645258281847e-55,Flexible HTH/homeodomain linker,True,assigned_too_few_test_positives +7392,36535,21.274218,0.99902344,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.984375,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9960391633288829,0.8368765926465235,0.004430660168365086,0.8,188.88304696032037,18.0,18.0,89.79066265060241,2.921620089201569e-35,Kinase ATP-binding P-loop,True,assigned_and_evaluated +7393,72011,23.906721,0.9970703,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.94091797,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,Bimodal apolar and Thr beta-strand,True,assigned_too_few_test_positives +7394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail-anchored helix,False,no_term_above_threshold +7395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inter-TM juxtamembrane linkers,False,no_term_above_threshold +7396,87697,21.423351,0.7011719,Knottin,keyword,87697,Knottin,0.7011719,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.773461885274329,0.20832050737387445,0.017279574656623838,,12.055881670329093,0.0,13.0,0.0,1.0,Extracellular beta-propellers and jelly-rolls,True,assigned_and_evaluated +7397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage helical scaffolds,False,no_term_above_threshold +7398,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class I aaRS KMSKS loop,False,no_term_above_threshold +7399,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic disordered loop motifs,False,no_term_above_threshold +7400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal topogenic helix,False,no_term_above_threshold +7401,45290,29.149574,0.96972656,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.96972656,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9987659399424105,0.943485086342229,0.0057598582188746125,0.9230769230769231,163.80352614418544,15.0,15.0,73.42487684729065,3.1139070649328504e-28,Kinase β3–αC helix activation,True,assigned_and_evaluated +7402,36091,31.477955,0.9995117,GNAT domain,interpro,85712,3.40.630.30,0.9995117,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,5.0,17.0,110.98473566641847,1.5248418337865543e-09,Conserved catalytic helix-loop motif,True,assigned_too_few_test_positives +7403,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-loop interface regions,False,no_term_above_threshold +7404,82029,21.634933,0.9897461,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.66552734,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,10.0,16.0,117.54929022082018,3.1004568402390717e-19,MATE/MOP transmembrane helix cores,True,assigned_too_few_test_positives +7405,88022,16.151518,0.75439453,Ribosomal protein,keyword,88022,Ribosomal protein,0.75439453,279,keywords,Ribosomal protein,keyword:keywords:Ribosomal protein,50.0,2257.0,0.8691753511554146,0.14573963120565472,0.022153300841825433,,6.578686952623254,0.0,8.0,0.0,1.0,Generic hydrophobic packing signal,True,assigned_and_evaluated +7406,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidoglycan hydrolase catalytic-cleft loop,False,no_term_above_threshold +7407,39958,21.240395,0.8222656,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8222656,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9942247889826744,0.22851227327033774,0.002658396101019052,,85.95870012852538,0.0,13.0,0.0,1.0,Extracytoplasmic PPIase chaperones and serpins,True,assigned_and_evaluated +7408,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GPI catalytic helical motif,False,no_term_above_threshold +7409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil tethers,False,no_term_above_threshold +7410,85364,24.776947,0.890625,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.890625,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,18.0,284.3874859708193,6.285282157931668e-41,Extracellular/periplasmic juxtamembrane helices/linkers,True,assigned_too_few_test_positives +7411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short surface-exposed interfacial motifs,False,no_term_above_threshold +7412,36091,23.464575,0.9663086,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.94189453,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,13.0,0.0,1.0,GAF hydrophobic core motif,True,assigned_too_few_test_positives +7413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved YGxxK helical motif,False,no_term_above_threshold +7414,43626,20.820711,0.9536133,Putative DNA-binding domain superfamily,interpro,43626,Putative DNA-binding domain superfamily,0.9536133,26,ip,IPR009061,interpro:ip:IPR009061,5.0,2257.0,0.9986678507992895,0.48357142857142854,0.002215330084182543,1.0,218.28414285714285,11.0,19.0,547.8955722639932,1.8900485873348936e-28,Short N-terminal interface helix,True,assigned_and_evaluated +7415,85649,21.844679,0.9423828,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9394531,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9230664435016154,0.2048966586753518,0.0101905183872397,,20.106598201316043,2.0,14.0,15.802014312218391,0.011838431025342341,Mid-domain Rossmann-like loops,True,assigned_and_evaluated +7416,38317,20.905357,0.98339844,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.98339844,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9813968253968253,0.13401253275202854,0.0031014621178555605,,43.2094694887612,0.0,17.0,0.0,1.0,Glycine-rich active-site loops,True,assigned_and_evaluated +7417,88160,17.645939,0.8574219,Transmembrane beta strand,keyword,25167,cell outer membrane,0.70703125,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,14.0,16.0,253.24453883495144,1.1644032443068986e-32,Outer membrane beta-barrel translocators,True,assigned_too_few_test_positives +7418,64620,16.837542,0.9609375,Histidine kinase/HSP90-like ATPase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8466797,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,15.0,15.0,324.0271739130435,8.124483338465097e-38,Histidine kinase ATPase hydrophobic core,True,assigned_too_few_test_positives +7419,58239,15.632377,0.6479492,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6479492,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7228856562922868,0.11187922563007638,0.017722640673460344,,6.3127853061770605,0.0,14.0,0.0,1.0,Short acidic catalytic loops,True,assigned_and_evaluated +7420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic amphipathic disordered segments,False,no_term_above_threshold +7421,64475,16.037415,0.84033203,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.82177734,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.8817016317016316,0.3242248583955626,0.0057598582188746125,0.6153846153846154,56.29042349221421,0.0,15.0,0.0,1.0,Cyclic dinucleotide active site loops,True,assigned_and_evaluated +7422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal-biased activation,False,no_term_above_threshold +7423,50338,16.515217,0.9707031,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6074219,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,Core pore-forming TM helices,True,assigned_too_few_test_positives +7424,85682,36.974136,0.8144531,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8144531,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9377867383512544,0.6921877722073932,0.011076650420912717,0.88,62.49071207488346,15.0,15.0,102.26586620926243,2.302639508687674e-30,Gly/Pro-rich NAD(P) Rossmann loops,True,assigned_and_evaluated +7425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix extracellular exit-cap,False,no_term_above_threshold +7426,72011,20.031813,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.92285156,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,15.0,15.0,590.3069306930694,9.761613975691778e-42,Conserved ANL AMP-binding loops,True,assigned_too_few_test_positives +7427,64058,22.427366,0.95410156,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.94873047,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9964174256416789,0.5884197313653307,0.006202924235711121,0.8571428571428571,94.86166669225366,18.0,18.0,113.99808795411089,4.371993551442556e-37,Hydrophobic-Asp cofactor-binding loops,True,assigned_and_evaluated +7428,37312,19.26281,0.99658203,"DNA-binding HTH domain, TetR-type",interpro,36354,RNA recognition motif domain,0.9526367,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,17.0,0.0,1.0,Histidine kinase ATP-lid motif,True,assigned_too_few_test_positives +7429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic and pore gating residues,False,no_term_above_threshold +7430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended SLiM-rich interaction surfaces,False,no_term_above_threshold +7431,49116,17.331093,0.70410156,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.70410156,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.7909413854351688,0.07588613203367302,0.002215330084182543,,34.255,0.0,12.0,0.0,1.0,Extended basic anion-binding groove,True,assigned_and_evaluated +7432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic pre-TM helical bundle,False,no_term_above_threshold +7433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular coiled-coil stalks,False,no_term_above_threshold +7434,49236,21.647066,0.8666992,C-type lectin fold,interpro,49236,C-type lectin fold,0.8666992,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9893872113676732,0.18253136042182697,0.002215330084182543,0.2,82.3946560944127,0.0,12.0,0.0,1.0,PDZ peptide-binding groove,True,assigned_and_evaluated +7435,64507,34.715385,0.9941406,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9941406,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997034400948992,0.9361111111111113,0.003987594151528578,1.0,234.75586419753094,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin repeat boundary signal,True,assigned_and_evaluated +7436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered/coiled-coil scaffolds,False,no_term_above_threshold +7437,85649,28.277136,0.97558594,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96972656,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9374197189677319,0.68748056585248,0.0101905183872397,0.7391304347826086,67.4627668316977,17.0,17.0,110.61410018552876,7.110790058883305e-35,MTase core helix/loop motif,True,assigned_and_evaluated +7438,49116,16.591278,0.85546875,Armadillo-type fold,interpro,88009,Repeat,0.61572266,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9672291296625222,0.26630943632454207,0.002215330084182543,0.2,120.2120795568983,1.0,20.0,4.351897810218978,0.32552345429018376,Coiled-coil/alpha-solenoid scaffolds,True,assigned_and_evaluated +7439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNP/chromatin basic IDRs,False,no_term_above_threshold +7440,37468,20.024868,0.9794922,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.9248047,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,17.0,0.0,1.0,Zinc-binding Cys/His microdomains,True,assigned_too_few_test_positives +7441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended hydrophobic binding interfaces,False,no_term_above_threshold +7442,87970,15.583976,0.6821289,Protein phosphatase,keyword,87970,Protein phosphatase,0.6821289,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,16.0,0.0,1.0,Phosphate-binding in carbohydrate enzymes,True,assigned_too_few_test_positives +7443,85649,29.489244,0.98779297,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9848633,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9673134560741117,0.7919182315895205,0.0101905183872397,0.782608695652174,77.71128037815424,18.0,18.0,110.61410018552876,7.381758732295342e-37,Post-Motif I SAM pocket loop,True,assigned_and_evaluated +7444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil scaffolds,False,no_term_above_threshold +7445,69819,23.976603,0.8544922,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8232422,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,17.0,17.0,419.86619718309856,1.776833158726609e-44,Carbohydrate kinase C-terminal lobe,True,assigned_too_few_test_positives +7446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic post-TM helix-tail,False,no_term_above_threshold +7447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TOPRIM two-metal catalytic core,False,no_term_above_threshold +7448,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long extracellular ectodomains,False,no_term_above_threshold +7449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CRISPR/CBASS effector domain activation,False,no_term_above_threshold +7450,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich disordered C-terminal tails,False,no_term_above_threshold +7451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Focal residue motif peaks,False,no_term_above_threshold +7452,84152,24.198675,0.90771484,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.90771484,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,C-terminal metalloenzyme catalytic core,True,assigned_too_few_test_positives +7453,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly leader,False,no_term_above_threshold +7454,72011,19.538952,0.97998047,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36104,Rho GTPase-activating protein domain,0.90478516,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,13.0,0.0,1.0,Caspase-like catalytic helix-loop,True,assigned_too_few_test_positives +7455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand hydrophobic core,False,no_term_above_threshold +7456,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic disordered tail after TM,False,no_term_above_threshold +7457,36091,19.229994,0.984375,GNAT domain,interpro,37071,Homeodomain,0.94433594,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,17.0,0.0,1.0,CBS β–loop–β connector,True,assigned_too_few_test_positives +7458,87732,17.404083,0.6982422,Lipid transport,keyword,87732,Lipid transport,0.6982422,44,keywords,Lipid transport,keyword:keywords:Lipid transport,,,,,,,,3.0,18.0,41.57670850767085,9.128037974457753e-05,Helix caps and low-complexity tails,True,assigned_too_few_test_positives +7459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal receptor-binding interface,False,no_term_above_threshold +7460,38654,22.365765,0.99658203,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99658203,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,FAR1/FRS transcription factor marker,True,assigned_too_few_test_positives +7461,36499,26.258928,0.9638672,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.9638672,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,10.0,0.0,1.0,Non-catalytic binding-site face,True,assigned_too_few_test_positives +7462,31094,17.805988,0.9584961,phosphopantetheine binding,go_mf,85682,NAD(P)-binding Rossmann-like Domain,0.6542969,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9995549621717846,0.9064610389610389,0.004430660168365086,1.0,204.5882564935065,0.0,15.0,0.0,1.0,NADP-adjacent MDR helix-strand,True,assigned_and_evaluated +7463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MCP methyl-accepting domain activation,False,no_term_above_threshold +7464,47717,15.650133,0.93652344,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7133789,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,20.0,0.0,1.0,NB-ARC pre-P-loop motif,True,assigned_too_few_test_positives +7465,87326,19.372696,0.6040039,Coiled coil,keyword,87326,Coiled coil,0.6040039,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.5774104440482607,0.11270446897005727,0.03943287549844927,0.0449438202247191,2.8581346793867333,19.0,20.0,11.977151617678155,5.677614873654298e-20,Long charged terminal IDRs,True,assigned_and_evaluated +7466,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDR and signal peptide activation,False,no_term_above_threshold +7467,37894,30.784555,0.94091797,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.94091797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,6.0,16.0,266.16517857142856,1.1699138201238792e-13,Polyketide PT/KR/ER activation,True,assigned_too_few_test_positives +7468,85762,33.523438,0.9033203,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.89208984,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,16.0,205.58965517241379,4.0182436921199225e-37,Active site cofactor lid,True,assigned_too_few_test_positives +7469,81685,25.71957,0.9916992,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9819336,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9978470675575353,0.9309523809523811,0.005316792202038104,0.9166666666666666,175.096626984127,19.0,19.0,85.66235632183908,8.858414841848649e-37,HRD+4 catalytic-loop residue,True,assigned_and_evaluated +7470,8200,20.285418,0.71484375,proteolysis,go_bp,88058,Signal,0.6020508,331,go,GO:0006508,go_bp:go:GO:0006508,24.0,2257.0,0.7064580534408121,0.05938513775756974,0.010633584404076208,,5.584677329951454,1.0,12.0,4.016504985179196,0.35034074045425145,Hydrolase active-site rim loops,True,assigned_and_evaluated +7471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro secondary-structure capping loops,False,no_term_above_threshold +7472,59229,34.1155,0.9794922,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9794922,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8852613755789965,0.7510076006155832,0.0101905183872397,0.7391304347826086,73.69670237345092,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM/SAH loop-helix junction,True,assigned_and_evaluated +7473,81858,16.654123,0.90283203,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.69091797,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,13.0,0.0,1.0,Transmembrane helix interfaces,True,assigned_too_few_test_positives +7474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal acidic disordered regions,False,no_term_above_threshold +7475,48883,20.218794,0.91845703,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.91845703,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,14.0,14.0,480.8145161290322,8.741512687097007e-38,Noncatalytic PLP terminal extensions,True,assigned_too_few_test_positives +7476,69819,23.57673,0.91308594,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.88671875,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,Active-site lid loop,True,assigned_too_few_test_positives +7477,87489,15.74682,0.8876953,GPI-anchor,keyword,88058,Signal,0.86572266,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.871015873015873,0.04296601230668791,0.0031014621178555605,,13.8534699680278,3.0,19.0,23.244054580896687,0.0004999571523881792,Sec-targeting boundary residue,True,assigned_and_evaluated +7478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral N-terminal helix/strand junctions,False,no_term_above_threshold +7479,36010,15.990205,0.99316406,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9716797,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,9.0,19.0,241.38056680161944,7.399774603250188e-20,Asp-adjacent N-cap motif,True,assigned_too_few_test_positives +7480,83302,15.70609,0.9042969,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9033203,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9708977576297255,0.21888608110694127,0.004873726185201595,0.09090909090909091,44.911444096215135,3.0,16.0,38.54806034482758,0.00011154099103450556,Strand-edge cap/hinge residues,True,assigned_and_evaluated +7481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Envelope nanomachine periplasmic scaffolds,False,no_term_above_threshold +7482,47717,25.507795,0.9873047,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9873047,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,11.0,248.62802335279397,1.1046647748237842e-23,SF2 helicase inter-lobe hinge,True,assigned_too_few_test_positives +7483,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-basic polyanion-binding patch,False,no_term_above_threshold +7484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich disordered linkers,False,no_term_above_threshold +7485,63951,19.971003,0.97021484,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9682617,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9971085409252669,0.4939455606122273,0.003987594151528578,0.7777777777777778,123.870570033533,4.0,18.0,35.80840840840841,7.868790956231895e-06,Ig/FN3 strand-loop hotspots,True,assigned_and_evaluated +7486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic alpha-helical scaffold signal,False,no_term_above_threshold +7487,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Extracytoplasmic regulators, global beta-strand peaks",False,no_term_above_threshold +7488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CA N-terminal catalytic signature,False,no_term_above_threshold +7489,87326,42.36842,0.7480469,Coiled coil,keyword,87326,Coiled coil,0.7480469,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7616894357145819,0.36887048579404175,0.03943287549844927,0.43820224719101125,9.354389735248901,18.0,18.0,12.607528018608585,3.905291109887263e-20,Coiled-coil a/d core register,True,assigned_and_evaluated +7490,85672,26.970037,0.6923828,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.68066406,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6621391765471009,0.27820894455877077,0.01595037660611431,0.3333333333333333,17.44215521858738,17.0,17.0,40.01409395973155,1.7557395315514075e-27,RecA-like helicase coupling hinge,True,assigned_and_evaluated +7491,45714,15.556608,0.97802734,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9326172,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,HisKA DHp H-box helix,True,assigned_too_few_test_positives +7492,88252,15.703034,0.9003906,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.88134766,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.9838092033583286,0.2665557320438501,0.012405848471422242,,21.486295972248914,0.0,13.0,0.0,1.0,Glycine-rich active-site loops,True,assigned_and_evaluated +7493,87882,21.448767,0.67285156,Palmitate,keyword,87735,Lipoprotein,0.6196289,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.7415963275581223,0.08348408020539168,0.002658396101019052,,31.403928170594835,15.0,20.0,49.961731843575414,1.6409503528841233e-23,Folded extracytoplasmic domain detector,True,assigned_and_evaluated +7494,36091,22.24919,0.9482422,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.8964844,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,12.0,0.0,1.0,PAS/GAF/PAC linker loops,True,assigned_too_few_test_positives +7495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature hydrolase catalytic domain,False,no_term_above_threshold +7496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic complex assembly scaffolds,False,no_term_above_threshold +7497,82029,19.687952,0.99853516,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6513672,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,Transporter TM-helix signature,True,assigned_too_few_test_positives +7498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic coil-helix boundary segments,False,no_term_above_threshold +7499,36115,23.563929,0.99853516,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.98876953,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,18.0,18.0,370.3167701863354,5.83715668822091e-46,BTB BACK CRL3 interface,True,assigned_too_few_test_positives +7500,64585,15.767521,0.9121094,"Zinc finger, CCCH-type superfamily",interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8930664,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,15.0,0.0,1.0,SAM-site beta-loop-helix module,True,assigned_too_few_test_positives +7501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helix bundles,False,no_term_above_threshold +7502,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-sheet turn motifs,False,no_term_above_threshold +7503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved C-terminal loop segments,False,no_term_above_threshold +7504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ASCH domain catalytic core,False,no_term_above_threshold +7505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated coiled-coil rod domains,False,no_term_above_threshold +7506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global coverage internal structure peaks,False,no_term_above_threshold +7507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil scaffolds,False,no_term_above_threshold +7508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MIF4G amphipathic helices,False,no_term_above_threshold +7509,59229,40.43601,0.890625,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.890625,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8665875209217236,0.5827870359935269,0.0101905183872397,0.6521739130434783,57.189145227712615,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM-transferase active-site lid,True,assigned_and_evaluated +7510,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal peptides and low-complexity regions,False,no_term_above_threshold +7511,85672,17.638107,0.6015625,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.6015625,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5516659162539397,0.0739548009919273,0.01595037660611431,0.05555555555555555,4.636555162188332,13.0,14.0,37.15594439117929,5.005580378424267e-20,SF2 helicase N-terminal ATPase lobe,True,assigned_and_evaluated +7512,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices and caps,False,no_term_above_threshold +7513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-family sensory domains,False,no_term_above_threshold +7514,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core helix-loop segment,False,no_term_above_threshold +7515,88058,24.048773,0.64160156,Signal,keyword,88058,Signal,0.64160156,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6224219301027677,0.10752143207903016,0.09127159946832078,,1.1780382145746169,2.0,20.0,0.7204954682779456,1.0,Scattered short disordered segments,True,assigned_and_evaluated +7516,38317,16.278238,0.9379883,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9379883,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.806920634920635,0.13431320999189014,0.0031014621178555605,0.2857142857142857,43.30641642167086,0.0,17.0,0.0,1.0,N-terminal amphipathic targeting segment,True,assigned_and_evaluated +7517,37690,31.618092,0.99365234,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99365234,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9993650793650793,0.8044217687074828,0.0031014621178555605,1.0,259.3685617103984,16.0,16.0,180.66969696969696,3.043463426437458e-36,Ankyrin repeat linker residues,True,assigned_and_evaluated +7518,37446,20.20728,0.9765625,F-box domain,interpro,63831,F-box-like domain superfamily,0.9760742,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9779047619047619,0.08330950470729853,0.0031014621178555605,,26.86136458919611,0.0,17.0,0.0,1.0,Histidine kinase helix-start recognition,True,assigned_and_evaluated +7519,36776,15.840195,0.71435547,SANT/Myb domain,interpro,80926,Homeodomain-like,0.6303711,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.5775211017325633,0.012019251652809995,0.002658396101019052,,4.521241830065359,0.0,19.0,0.0,1.0,Catalytic-site neighborhood detector,True,assigned_and_evaluated +7520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic enzyme domain scaffold,False,no_term_above_threshold +7521,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cation channel pore domain,False,no_term_above_threshold +7522,85675,19.506647,0.94433594,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9375,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,16.0,20.0,437.58532110091744,2.126379772892377e-40,Disordered acidic low-complexity linkers,True,assigned_too_few_test_positives +7523,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse isoleucine composition bias,False,no_term_above_threshold +7524,87489,39.82476,0.89990234,GPI-anchor,keyword,87489,GPI-anchor,0.89990234,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9245714285714286,0.3218716374454079,0.0031014621178555605,0.42857142857142855,103.78061224489795,0.0,19.0,0.0,1.0,C-terminal surface anchoring signal,True,assigned_and_evaluated +7525,36091,16.395754,0.9926758,GNAT domain,interpro,63831,F-box-like domain superfamily,0.95214844,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,19.0,0.0,1.0,Helical hydrophobic core clusters,True,assigned_too_few_test_positives +7526,25169,22.297653,0.8833008,pilus,go_cc,25169,pilus,0.8833008,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.999733570159858,0.925,0.002215330084182543,1.0,417.5450000000001,9.0,16.0,310.52604166666663,4.514379890893985e-21,C-terminal beta-strand cap,True,assigned_and_evaluated +7527,37341,24.744577,0.9975586,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99365234,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,19.0,19.0,145.4170731707317,5.254240088122417e-41,WD40 blade loop turns,True,assigned_and_evaluated +7528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular ligand-binding loops,False,no_term_above_threshold +7529,47717,15.816537,0.9995117,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7832031,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,15.0,16.0,256.3976490825688,1.46477025389507e-35,RecA1 helicase Ia/Ib segment,True,assigned_too_few_test_positives +7530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil boundary caps,False,no_term_above_threshold +7531,72011,15.588182,0.953125,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.85791016,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,Cyclase C-terminal beta-alpha linker,True,assigned_too_few_test_positives +7532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline/Glycine-rich low-complexity IDRs,False,no_term_above_threshold +7533,88058,31.542715,0.6230469,Signal,keyword,88058,Signal,0.6230469,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5855810331687596,0.15046647355866372,0.09127159946832078,0.02912621359223301,1.6485574311742912,5.0,16.0,2.25154833836858,0.09818341684575585,Extracytoplasmic envelope protein signature,True,assigned_and_evaluated +7534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical interaction modules,False,no_term_above_threshold +7535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site pocket rim elements,False,no_term_above_threshold +7536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic CN hydrolase cores,False,no_term_above_threshold +7537,37894,22.884882,0.9765625,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9765625,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,19.0,0.0,1.0,DxG ATP/Mg2+-binding motif,True,assigned_too_few_test_positives +7538,27932,20.049759,0.6821289,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.6538086,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.7814566815922441,0.284067248404108,0.01949490474080638,0.3409090909090909,14.57135862836527,14.0,16.0,90.57009548611111,1.9790834964064468e-26,uL10/P0 whole-chain activation,True,assigned_and_evaluated +7539,36499,19.237066,0.90478516,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.90478516,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,12.0,0.0,1.0,Polybasic N-termini and catalytic loops,True,assigned_too_few_test_positives +7540,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic phosphorylation-regulated disordered tails,False,no_term_above_threshold +7541,36977,16.513863,0.9580078,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.8671875,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,3.0,19.0,49.030427631578945,5.661719975294051e-05,Kinase ATP-binding residue,True,assigned_too_few_test_positives +7542,81858,17.653357,0.88134766,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.65185547,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,1.0,16.0,16.343475877192983,0.09754279916968842,Transmembrane helix boundary motif,True,assigned_too_few_test_positives +7543,37640,15.731364,0.95458984,EF-hand domain,interpro,46081,EF-hand domain pair,0.9394531,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,17.0,0.0,1.0,Amphipathic structural alpha helices,True,assigned_too_few_test_positives +7544,87276,27.561806,0.60595703,Cell membrane,keyword,87276,Cell membrane,0.60595703,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7055735184883596,0.3847702234611729,0.11120957022596367,0.450199203187251,3.459866112955646,10.0,15.0,5.470318377832829,2.305628061442585e-06,Transmembrane helix boundary motifs,True,assigned_and_evaluated +7545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich regulatory IDRs,False,no_term_above_threshold +7546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ARH C-terminal catalytic subdomain,False,no_term_above_threshold +7547,36535,17.742989,0.9272461,Protein kinase domain,interpro,64148,Winged helix DNA-binding domain superfamily,0.7705078,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.980173564753004,0.3810373360994726,0.004430660168365086,0.4,86.00012675765097,0.0,18.0,0.0,1.0,Histidine kinase ATP-lid loops,True,assigned_and_evaluated +7548,87326,27.162006,0.66552734,Coiled coil,keyword,87326,Coiled coil,0.66552734,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7140998797628424,0.1864033975156034,0.03943287549844927,,4.72710638418783,13.0,19.0,8.626203381153243,1.7506259806341123e-10,Acidic IDR activation domains,True,assigned_and_evaluated +7549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helices,False,no_term_above_threshold +7550,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensory coupling modules,False,no_term_above_threshold +7551,49061,16.370228,0.8442383,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8442383,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9361821444593988,0.08659031553742862,0.012405848471422242,,6.979797934570585,0.0,15.0,0.0,1.0,Acidic/polar beta-loop residues,True,assigned_and_evaluated +7552,27735,18.090302,0.7705078,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,88150,Transcription regulation,0.64941406,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.7924956039030444,0.16939280258408276,0.011519716437749225,0.07692307692307693,14.704598285856722,4.0,18.0,10.052436351374135,0.001006205901382389,Acidic IDR transactivation regions,True,assigned_and_evaluated +7553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic N-terminal disordered regulatory tails,False,no_term_above_threshold +7554,48883,16.795689,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,14.0,14.0,480.8145161290322,8.741512687097007e-38,Conserved core scaffold helix,True,assigned_too_few_test_positives +7555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane anchor helix,False,no_term_above_threshold +7556,63960,26.614244,0.8852539,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.8852539,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,N-terminal active-site capping loop,True,assigned_too_few_test_positives +7557,88153,17.709017,0.6582031,Transferase,keyword,88153,Transferase,0.6582031,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8066165661774533,0.2787621669770959,0.052724856003544526,0.29411764705882354,5.287111015691642,1.0,16.0,0.7090984776403425,1.0,ATP-grasp N-terminal hydrophobic helix,True,assigned_and_evaluated +7558,87108,17.51169,0.83496094,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.83203125,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8559707394226967,0.05130009511973183,0.003987594151528578,,12.864923853914972,1.0,20.0,8.468892045454545,0.18012505039439194,Extended modular scaffolds,True,assigned_and_evaluated +7559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T-Pro-rich regulatory IDRs,False,no_term_above_threshold +7560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane catalytic loops,False,no_term_above_threshold +7561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Near-global activation with structured peaks,False,no_term_above_threshold +7562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered interaction tails,False,no_term_above_threshold +7563,83419,17.79229,0.90625,2.60.120.200,gene3d,83419,2.60.120.200,0.90625,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,0.0,16.0,0.0,1.0,Extracellular beta-sheet ligand-binding surfaces,True,assigned_too_few_test_positives +7564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic α/β scaffold blocks,False,no_term_above_threshold +7565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helices and signals,False,no_term_above_threshold +7566,43583,18.672194,0.9785156,"Peptidase S1, PA clan",interpro,88049,Serine protease,0.7480469,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,14.0,14.0,416.9300699300699,6.605101239071875e-37,Pre-His glycine-rich strand,True,assigned_and_evaluated +7567,38317,27.725166,0.9868164,Pentatricopeptide repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.93115234,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9857142857142858,0.10470322268167521,0.0031014621178555605,,33.759310513220136,0.0,10.0,0.0,1.0,Post-P-loop helix hydrophobe,True,assigned_and_evaluated +7568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich disordered tails,False,no_term_above_threshold +7569,46081,15.940723,0.96777344,EF-hand domain pair,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.84814453,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.9877445531347264,0.15182678110003692,0.003544528134692069,,42.83413061784792,0.0,16.0,0.0,1.0,Alpha-helix start detector,True,assigned_and_evaluated +7570,37894,20.611038,1.0,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8588867,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR Rossmann beta-strand signature,True,assigned_too_few_test_positives +7571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interdomain helical packing residues,False,no_term_above_threshold +7572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic helix motif,False,no_term_above_threshold +7573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic center proximal motifs,False,no_term_above_threshold +7574,85762,33.185623,0.86572266,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.85058594,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,16.0,205.58965517241379,4.0182436921199225e-37,FAD-proximal active-site lid,True,assigned_too_few_test_positives +7575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal tails,False,no_term_above_threshold +7576,36104,15.8359585,0.9638672,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9638672,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Proline-centered structural kinks,True,assigned_too_few_test_positives +7577,45804,22.985971,0.9946289,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.98046875,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,19.0,20.0,262.2219907407407,7.343535282548398e-45,MFS helix-to-coil gating loops,True,assigned_too_few_test_positives +7578,82029,16.329031,0.93652344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.89941406,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,Transmembrane helix entry anchors,True,assigned_too_few_test_positives +7579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM2-HAMP signal relay,False,no_term_above_threshold +7580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved mid-sequence α/β motif,False,no_term_above_threshold +7581,88161,76.45748,0.83935547,Transmembrane helix,keyword,88161,Transmembrane helix,0.83935547,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8256164633510582,0.609722272690424,0.1847585290208241,0.7362110311750599,3.3001035238903764,14.0,17.0,4.469699322605692,3.978602330867186e-08,Positive-inside N-region,True,assigned_and_evaluated +7582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ras-GEF N-terminal peaks,False,no_term_above_threshold +7583,87384,19.531334,0.6694336,DNA-binding,keyword,87384,DNA-binding,0.6694336,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.5351850291609328,0.04296289518765051,0.043863535666814356,,0.9794672165507797,3.0,20.0,1.8375077049517154,0.34769866956837875,Short disordered low-complexity segments,True,assigned_and_evaluated +7584,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered juxtamembrane C-terminal tails,False,no_term_above_threshold +7585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal charged low-complexity IDRs,False,no_term_above_threshold +7586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered linkers,False,no_term_above_threshold +7587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP PP-binding loop,False,no_term_above_threshold +7588,82029,32.138226,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS TM6/TM12 crossover helices,True,assigned_too_few_test_positives +7589,31094,16.560015,0.9423828,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.64941406,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9466399643969736,0.5274051618919758,0.004430660168365086,0.7,119.03534503901895,0.0,14.0,0.0,1.0,N-terminal Rossmann/FNR starter motif,True,assigned_and_evaluated +7590,85682,28.896582,0.9238281,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.9238281,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9966218637992832,0.7635665863203565,0.011076650420912717,0.96,68.93479141300178,10.0,10.0,102.26586620926243,1.9453282264469492e-20,SDR Rossmann NxxSP-adjacent loop,True,assigned_and_evaluated +7591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site metal-coordination motifs,False,no_term_above_threshold +7592,28225,18.092169,0.8691406,metalloendopeptidase activity,go_mf,28225,metalloendopeptidase activity,0.8691406,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,7.0,17.0,125.25420168067227,1.589621467946562e-13,Post-HExxH Zn-binding segment,True,assigned_too_few_test_positives +7593,87274,19.388313,0.6958008,Cell inner membrane,keyword,88161,Transmembrane helix,0.68896484,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.8581892247639796,0.5694898672613868,0.0358883473637572,0.7037037037037037,15.868378153196915,7.0,14.0,19.49672988881622,4.201574985180785e-08,Hydrophobic transmembrane helices,True,assigned_and_evaluated +7594,64596,16.737366,0.984375,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.984375,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane metal-transport residues,True,assigned_too_few_test_positives +7595,87489,23.203331,0.9194336,GPI-anchor,keyword,88161,Transmembrane helix,0.69970703,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8306031746031746,0.0514240566295049,0.0031014621178555605,,16.580585116113223,0.0,18.0,0.0,1.0,Lumenal juxtamembrane TM starts,True,assigned_and_evaluated +7596,88273,15.7160225,0.78759766,mRNA processing,keyword,87857,Nucleus,0.60595703,111,keywords,mRNA processing,keyword:keywords:mRNA processing,,,,,,,,8.0,19.0,35.06086445163187,5.974511187756615e-11,RS/RG-rich disordered linkers,True,assigned_too_few_test_positives +7597,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C/PPM active-site rim,False,no_term_above_threshold +7598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adjacent phosphate-binding helix-loop segments,False,no_term_above_threshold +7599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,All-beta repeat scaffold strands,False,no_term_above_threshold +7600,37640,24.043697,0.99560547,EF-hand domain,interpro,46081,EF-hand domain pair,0.9902344,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,18.0,19.0,283.83443533456756,3.442883074399642e-43,EF-hand E-helix detector,True,assigned_too_few_test_positives +7601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase substrate binding loop,False,no_term_above_threshold +7602,88009,23.493855,0.6694336,Repeat,keyword,88009,Repeat,0.6694336,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7556154079218766,0.20970419702967902,0.07266282676118742,0.10975609756097561,2.885990077414546,11.0,18.0,5.417852127220157,1.0734360642186987e-06,Disordered S/T-rich low-complexity repeats,True,assigned_and_evaluated +7603,84152,23.652159,0.88134766,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.88134766,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,13.0,13.0,562.4622641509434,4.627751018381797e-36,Metallohydrolase active-site neighborhoods,True,assigned_too_few_test_positives +7604,10369,18.396421,0.7211914,DNA integration,go_bp,88163,Transposable element,0.62060547,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,4.0,16.0,136.74541284403668,3.774830622953936e-08,Broad disordered linker activation,True,assigned_too_few_test_positives +7605,58239,15.592807,0.7158203,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7158203,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7749379792512405,0.05887943928639007,0.017722640673460344,,3.32227236173456,15.0,15.0,35.851473241130485,1.3063198800490947e-23,Noncatalytic C-terminal motor hinges,True,assigned_and_evaluated +7606,49116,22.958317,0.98046875,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.98046875,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9992007104795737,0.8714285714285714,0.002215330084182543,0.8,393.3628571428572,20.0,20.0,87.03795620437957,8.990576307619231e-39,Alpha-solenoid HEAT/ARM repeats,True,assigned_and_evaluated +7607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue TM hairpin interfaces,False,no_term_above_threshold +7608,83419,19.409683,0.9394531,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9326172,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,16.0,19.0,306.1412066752246,3.3556839336594273e-38,Extracellular glycan-binding loops,True,assigned_too_few_test_positives +7609,85791,34.188744,0.9995117,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.98583984,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,11.0,12.0,594.0498188405797,2.9205503512904336e-30,Noncatalytic MBL lid regions,True,assigned_too_few_test_positives +7610,45288,20.241282,0.9819336,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9819336,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,15.0,15.0,462.17829457364337,3.960299025280445e-40,C-terminal effector regions,True,assigned_too_few_test_positives +7611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic helix cap,False,no_term_above_threshold +7612,87276,29.613077,0.6557617,Cell membrane,keyword,88161,Transmembrane helix,0.64404297,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7369743359562747,0.33100402948933516,0.11120957022596367,0.13545816733067728,2.9763987830973284,14.0,14.0,8.205477566749243,3.530437300903477e-13,Hydrophobic TM helix boundaries,True,assigned_and_evaluated +7613,63774,17.156185,0.9824219,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.9824219,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,16.0,0.0,1.0,Helix-helix hydrophobic interface,True,assigned_too_few_test_positives +7614,87523,17.487684,0.60498047,Glycosidase,keyword,87523,Glycosidase,0.60498047,108,keywords,Glycosidase,keyword:keywords:Glycosidase,8.0,2257.0,0.6186082703423744,0.048491729434352385,0.003544528134692069,,13.680729166666667,14.0,16.0,98.43089622641509,6.2131172882933065e-27,GH substrate-binding cleft loops,True,assigned_and_evaluated +7615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered tails/linkers and TM flanks,False,no_term_above_threshold +7616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine helix capping hinges,False,no_term_above_threshold +7617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-sensing beta-alpha loops,False,no_term_above_threshold +7618,45290,38.50554,0.9736328,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9736328,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9613842040312628,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase ATP-binding P-loop region,True,assigned_and_evaluated +7619,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transmembrane helix bundles,False,no_term_above_threshold +7620,85656,19.530003,0.6616211,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.6616211,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.7107936507936509,0.3946294069244889,0.0031014621178555605,0.42857142857142855,127.23979591836735,10.0,10.0,141.281990521327,7.760530161277081e-22,Secreted hydrolase cap/lid,True,assigned_and_evaluated +7621,85656,20.448078,0.94873047,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.9472656,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9951111111111111,0.40529262404262406,0.0031014621178555605,0.2857142857142857,130.67792178060034,18.0,19.0,133.8460962833624,1.6646855487414717e-37,C-terminal alpha-helix activation,True,assigned_and_evaluated +7622,81685,24.081177,0.9692383,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96728516,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9979584261321455,0.931592039800995,0.005316792202038104,0.9166666666666666,175.21693615257047,15.0,15.0,85.66235632183908,3.186653641792077e-29,Conserved kinase αE helix,True,assigned_and_evaluated +7623,49236,16.863552,0.7475586,C-type lectin fold,interpro,49236,C-type lectin fold,0.7475586,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.5934280639431616,0.04177226406734604,0.002215330084182543,,18.856000000000005,0.0,13.0,0.0,1.0,c-di-GMP PDE catalytic core,True,assigned_and_evaluated +7624,59224,20.251282,0.91308594,Alpha/Beta hydrolase fold,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.87060547,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9654603174603175,0.046870250128610715,0.0031014621178555605,,15.112307791467769,0.0,13.0,0.0,1.0,CoA carboxyltransferase core anchors,True,assigned_and_evaluated +7625,38317,21.455936,0.99658203,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.8979492,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9998730158730158,0.9617346938775508,0.0031014621178555605,1.0,310.09074344023315,17.0,19.0,344.16196943972835,8.389129330212028e-42,PPR H1 amphipathic helix,True,assigned_and_evaluated +7626,49061,16.584354,0.8457031,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8457031,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9098410562071397,0.06193702721964143,0.012405848471422242,,4.9925668012403825,0.0,19.0,0.0,1.0,Polar loops flanking functional sites,True,assigned_and_evaluated +7627,85682,16.368774,0.703125,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.703125,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9292114695340501,0.36604244147882836,0.011076650420912717,0.56,33.04631161670862,0.0,10.0,0.0,1.0,Cofactor-binding loop-helix segment,True,assigned_and_evaluated +7628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed coupling loops,False,no_term_above_threshold +7629,86130,18.433638,0.8984375,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.89697266,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.8471746031746032,0.34706512311062326,0.0031014621178555605,0.2857142857142857,111.90371183723953,16.0,19.0,202.44821731748723,2.4981832979692877e-35,Fungal C-terminal regulatory tails,True,assigned_and_evaluated +7630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix start capping motif,False,no_term_above_threshold +7631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular surface-interaction loops,False,no_term_above_threshold +7632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-engaging lids and FH1,False,no_term_above_threshold +7633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease cleft-adjacent activation,False,no_term_above_threshold +7634,85672,19.115953,0.6401367,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.63427734,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6417592175696633,0.12360530733451455,0.01595037660611431,0.05555555555555555,7.7493660737222045,2.0,16.0,5.001761744966443,0.09748758712992651,TIR/SEFIR BB-loop hotspot,True,assigned_and_evaluated +7635,38317,24.905956,0.80615234,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.80615234,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7067619047619048,0.04187319574436466,0.0031014621178555605,,13.501114685004435,0.0,16.0,0.0,1.0,DNA-binding hinge helix,True,assigned_and_evaluated +7636,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta strand-loop surfaces,False,no_term_above_threshold +7637,52236,24.91557,0.99658203,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99609375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR/HEAT helix-B C-cap,True,assigned_too_few_test_positives +7638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta1 loop motif,False,no_term_above_threshold +7639,45551,22.994696,0.9892578,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9892578,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,16.0,0.0,1.0,Interdomain boundary hinge elements,True,assigned_too_few_test_positives +7640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal end structure detector,False,no_term_above_threshold +7641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDR/linker patches and motifs,False,no_term_above_threshold +7642,85664,18.8615,0.98046875,Glycogen Phosphorylase B;,gene3d,46081,EF-hand domain pair,0.8955078,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Acidic donor-binding helix,True,assigned_too_few_test_positives +7643,46932,20.285357,0.74609375,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.74609375,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.6776145972407653,0.028749080128160076,0.004430660168365086,,6.48866738492573,0.0,15.0,0.0,1.0,N-terminal β/Cys-loop micro-motifs,True,assigned_and_evaluated +7644,64507,33.287495,0.9946289,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9946289,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9998022933965995,0.9575757575757577,0.003987594151528578,1.0,240.1387205387206,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin inter-repeat loop detector,True,assigned_and_evaluated +7645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Patchy structural-region peaks,False,no_term_above_threshold +7646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid enzyme transmembrane anchors,False,no_term_above_threshold +7647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity regulatory tails,False,no_term_above_threshold +7648,45714,16.197723,0.8574219,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.8574219,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,4.0,19.0,62.758947368421055,8.873813422925273e-07,Nuclear low-complexity activation IDRs,True,assigned_too_few_test_positives +7649,81799,17.218412,0.85253906,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6425781,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,2.0,12.0,96.47411003236245,0.00034854716199725404,AAA+ NTPase core activation,True,assigned_too_few_test_positives +7650,43624,16.447195,0.828125,Homedomain-like superfamily,interpro,87384,DNA-binding,0.6508789,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.7971748103525212,0.018589030359442052,0.007089056269384138,,2.6222150950787944,0.0,20.0,0.0,1.0,Alpha-helical interaction elements,True,assigned_and_evaluated +7651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral structural beta-sheet scaffolds,False,no_term_above_threshold +7652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal interaction tails,False,no_term_above_threshold +7653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs flanking domains,False,no_term_above_threshold +7654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VSD S3 paddle region,False,no_term_above_threshold +7655,37007,25.250902,0.9970703,Metallo-beta-lactamase,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.98535156,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,9.0,16.0,465.7890625,1.0323915883416961e-22,Hydrolase active site flanking loops,True,assigned_too_few_test_positives +7656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory lumen-exposed regions,False,no_term_above_threshold +7657,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M13 metallopeptidase active-site residues,False,no_term_above_threshold +7658,59229,27.610334,0.7475586,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7475586,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7312677591374411,0.3364961925118731,0.0101905183872397,0.34782608695652173,33.0205176738825,10.0,10.0,106.27629233511585,1.3285914921647095e-20,RNA-targeting accessory domains,True,assigned_and_evaluated +7659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Toxin N-termini and siderophore ligases,False,no_term_above_threshold +7660,64026,15.959112,0.87841797,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.7910156,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.870131793277062,0.015568286325243161,0.002658396101019052,,5.856270372678969,1.0,16.0,10.586115056818182,0.14670215503523074,Hydrophobic transmembrane alpha helices,True,assigned_and_evaluated +7661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich cytoskeletal IDRs,False,no_term_above_threshold +7662,81685,23.939188,0.9682617,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.88134766,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9567743132887899,0.9171097326835032,0.005316792202038104,0.9166666666666666,172.49305555555554,20.0,20.0,85.66235632183908,1.209373710987114e-38,Protein kinase activation-loop signature,True,assigned_and_evaluated +7663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MHD/ZU5 β-sandwich interaction domains,False,no_term_above_threshold +7664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed N-terminal assembly microdomains,False,no_term_above_threshold +7665,37894,17.462961,0.7973633,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7973633,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,13.0,0.0,1.0,ABC NBD Q-loop motif,True,assigned_too_few_test_positives +7666,87413,18.854342,0.60595703,Disulfide bond,keyword,87413,Disulfide bond,0.60595703,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.63027343174519,0.10250198453872339,0.0717766947275144,,1.4280677722462882,4.0,16.0,2.956804205514779,0.06738238878902962,Hydrophobic β-strand core signature,True,assigned_and_evaluated +7667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical solenoid PPI scaffolds,False,no_term_above_threshold +7668,45551,16.589624,0.8847656,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8847656,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,16.0,0.0,1.0,N-terminal amphipathic targeting/assembly patches,True,assigned_too_few_test_positives +7669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundary detector,False,no_term_above_threshold +7670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic TM1-TM2 interfacial loop,False,no_term_above_threshold +7671,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA primase-initiator modules,False,no_term_above_threshold +7672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DhaK GIHGEPG catalytic core,False,no_term_above_threshold +7673,38317,17.275154,0.8227539,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8227539,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8319047619047619,0.03427887429738302,0.0031014621178555605,,11.052488469884782,0.0,19.0,0.0,1.0,Extended alpha-helical/TM regions,True,assigned_and_evaluated +7674,58239,15.6758375,0.62060547,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.62060547,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6441249436175011,0.1134033004406022,0.017722640673460344,0.025,6.39878122736098,6.0,13.0,16.546833803598687,1.3047637865127665e-06,UvrC Tyr/Arg basic patch,True,assigned_and_evaluated +7675,36354,17.514652,0.86816406,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.8588867,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,16.0,0.0,1.0,Interdomain allosteric coupling hinges,True,assigned_too_few_test_positives +7676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-core and RNA-binding segments,False,no_term_above_threshold +7677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HisKA post-His LRTP helix,False,no_term_above_threshold +7678,87317,21.266273,0.83447266,Cleavage on pair of basic residues,keyword,88058,Signal,0.6660156,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.8850122713074521,0.20547584744472672,0.007089056269384138,0.1875,28.984936730171764,9.0,20.0,38.002053824362605,1.435794037632803e-12,Secreted cationic C-terminal peptides,True,assigned_and_evaluated +7679,87276,41.30807,0.69384766,Cell membrane,keyword,88161,Transmembrane helix,0.66748047,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7975366728499759,0.5104818918149022,0.11120957022596367,0.6454183266932271,4.590269441538782,9.0,19.0,3.88680516319701,0.00031181710365316216,Hydrophobic transmembrane α-helices,True,assigned_and_evaluated +7680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal linker-sensor segments,False,no_term_above_threshold +7681,39177,18.878603,0.7993164,Fibronectin type III,interpro,39177,Fibronectin type III,0.7993164,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,3.0,17.0,51.57525951557094,4.796639609795156e-05,Early mature-chain glycosylation activation,True,assigned_too_few_test_positives +7682,88252,16.617952,0.92871094,WD repeat,keyword,87413,Disulfide bond,0.6665039,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.9344436967249888,0.1897339294785015,0.012405848471422242,0.21428571428571427,15.29390995832064,1.0,16.0,8.048191144708424,0.1886091320035706,PQQ dehydrogenase C-terminal strand-coil,True,assigned_and_evaluated +7683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet interaction scaffolds,False,no_term_above_threshold +7684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic helix-loop capping gate,False,no_term_above_threshold +7685,81858,21.279493,0.93310547,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6123047,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Loop-to-TM helix junctions,True,assigned_too_few_test_positives +7686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NxWFTKL N-lobe helix,False,no_term_above_threshold +7687,87149,26.411322,0.76220703,Amphibian defense peptide,keyword,87162,Antimicrobial,0.68408203,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8371066461577903,0.17858829055613568,0.012405848471422242,,14.395491849471364,0.0,19.0,0.0,1.0,Membrane-active helical segments,True,assigned_and_evaluated +7688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site glycine-rich loop,False,no_term_above_threshold +7689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic interaction helices,False,no_term_above_threshold +7690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich disordered regulatory regions,False,no_term_above_threshold +7691,49061,35.484074,0.98339844,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98339844,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9915080433250015,0.4449291771796989,0.012405848471422242,0.42857142857142855,35.86446974623501,4.0,19.0,20.81557126647464,6.558015856335984e-05,Propeller strand-to-loop motif,True,assigned_and_evaluated +7692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Group III ADH helix motif,False,no_term_above_threshold +7693,59229,28.643784,0.9785156,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9785156,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8824393756568447,0.640713854223439,0.0101905183872397,0.6956521739130435,62.87352908618703,15.0,15.0,106.27629233511585,1.2978692612531535e-30,Rossmann cofactor-binding loop,True,assigned_and_evaluated +7694,36010,19.663794,0.9970703,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.92285156,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,17.0,18.0,481.27113010446345,9.801892057141367e-45,ABH acid–His helix,True,assigned_too_few_test_positives +7695,59224,16.443708,0.91308594,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7631836,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9626349206349206,0.19599328954919015,0.0031014621178555605,0.2857142857142857,63.19383635893174,0.0,14.0,0.0,1.0,Noncatalytic short helical hotspots,True,assigned_and_evaluated +7696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sec/X and low-complexity detector,False,no_term_above_threshold +7697,36449,16.237448,0.89501953,EamA domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.64404297,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,17.0,0.0,1.0,Helix N-cap and kinks,True,assigned_too_few_test_positives +7698,37071,16.76993,0.8935547,Homeodomain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8208008,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,20.0,0.0,1.0,Structural hydrophobic helical patches,True,assigned_too_few_test_positives +7699,38317,17.870964,0.9301758,Pentatricopeptide repeat,interpro,43624,Homedomain-like superfamily,0.91503906,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9348253968253968,0.025231359782890938,0.0031014621178555605,,8.135311289997835,0.0,13.0,0.0,1.0,Pre-HTH anchoring helix,True,assigned_and_evaluated +7700,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-proximal beta-alpha core,False,no_term_above_threshold +7701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane beta-barrel loops,False,no_term_above_threshold +7702,88160,17.010477,0.79296875,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6689453,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,20.0,231.5378640776699,6.036645647116142e-36,Flexible glycine-rich extracellular loops,True,assigned_too_few_test_positives +7703,49236,17.411455,0.79003906,C-type lectin fold,interpro,49236,C-type lectin fold,0.79003906,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.988809946714032,0.10422845922845922,0.002215330084182543,,47.0487264957265,0.0,18.0,0.0,1.0,Exposed beta-alpha N-cap patches,True,assigned_and_evaluated +7704,38873,19.064861,0.8691406,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78808594,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8947602131438721,0.1665969121706827,0.002215330084182543,,75.20184615384618,4.0,20.0,34.26494252873564,9.665803614288923e-06,Aromatic acidic hydrophobic helix motif,True,assigned_and_evaluated +7705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase actuator domain,False,no_term_above_threshold +7706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine/proline-rich acidic IDRs,False,no_term_above_threshold +7707,64148,25.808594,0.7026367,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7026367,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6249941206904661,0.13690467862167602,0.008418254319893664,0.10526315789473684,16.262834718374883,15.0,15.0,88.9865671641791,1.8111397886309825e-29,Charged amphipathic coiled-coil helices,True,assigned_and_evaluated +7708,84612,15.934116,0.9082031,"Knottin, scorpion toxin-like",gene3d,64317,"Knottin, scorpion toxin-like superfamily",0.9003906,34,gene3d,3.30.30.10,gene3d:gene3d:3.30.30.10,,,,,,,,0.0,17.0,0.0,1.0,Secretory propeptide α-helices,True,assigned_too_few_test_positives +7709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycan-binding loops,False,no_term_above_threshold +7710,36977,15.655944,0.9458008,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8857422,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,6.0,0.0,1.0,ABC NBD inter-Walker helix,True,assigned_too_few_test_positives +7711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal Gly-Arg strand-loop motif,False,no_term_above_threshold +7712,85388,30.280722,0.7573242,Glutaredoxin,gene3d,85388,Glutaredoxin,0.7573242,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.684554246331703,0.18971533008418254,0.003544528134692069,0.25,53.5234375,10.0,11.0,197.09421487603305,1.1289069867895294e-22,N-terminal redox cap linker,True,assigned_and_evaluated +7713,47717,18.089428,0.98828125,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6323242,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,15.0,18.0,227.90902140672782,6.625865018849735e-34,RecA2 hinge helix,True,assigned_too_few_test_positives +7714,46284,21.458813,0.9975586,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9975586,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,15.0,15.0,1192.42,2.062380056822838e-46,C-terminal cofactor-binding tails,True,assigned_too_few_test_positives +7715,84152,29.353302,0.9838867,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9838867,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,14.0,16.0,492.15448113207543,9.190988678163333e-37,Substrate-proximal scaffold regions,True,assigned_too_few_test_positives +7716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lys/Arg-rich N-cap patches,False,no_term_above_threshold +7717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged amphipathic helices,False,no_term_above_threshold +7718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory and transmembrane signals,False,no_term_above_threshold +7719,45804,25.758718,0.9902344,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.95947266,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,17.0,17.0,276.02314814814815,1.7512156980327852e-41,MFS TM1-TM2 hairpin junction,True,assigned_too_few_test_positives +7720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Edge-of-site residue marker,False,no_term_above_threshold +7721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain boundary hotspots,False,no_term_above_threshold +7722,38873,19.44766,0.9589844,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9482422,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9870337477797514,0.08869276617102703,0.002215330084182543,,40.03591464960161,0.0,17.0,0.0,1.0,GTPase post-P-loop α1 helix,True,assigned_and_evaluated +7723,47529,16.974108,0.71484375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.71484375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7434181169120928,0.3443747826502914,0.007089056269384138,0.375,48.578367777606736,1.0,8.0,9.66618028534371,0.16010216655496784,Collagen/EGF repeats and Ig/FN3 linkers,True,assigned_and_evaluated +7724,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cys/His-rich zinc segments,False,no_term_above_threshold +7725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface aromatic/basic loop motif,False,no_term_above_threshold +7726,80926,16.291758,0.8100586,Homeodomain-like,gene3d,80926,Homeodomain-like,0.8100586,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.7693507472919238,0.061624440859447946,0.0057598582188746125,,10.698951001521078,0.0,14.0,0.0,1.0,Amphipathic helical interaction motifs,True,assigned_and_evaluated +7727,82107,15.598081,0.62939453,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.6118164,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,16.0,0.0,1.0,N-terminal pocket-lining loop,True,assigned_too_few_test_positives +7728,59224,30.13511,0.97216797,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97216797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Catalytic serine nucleophile elbow,True,assigned_and_evaluated +7729,63831,15.64056,0.67041016,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.67041016,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5708944172960166,0.007962456520964153,0.002658396101019052,,2.995210727969349,0.0,15.0,0.0,1.0,Assembly interface motifs,True,assigned_and_evaluated +7730,88160,19.44438,0.78759766,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6713867,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,16.0,235.15564320388347,1.4007539360355413e-29,Aromatic β-barrel hairpin initiators,True,assigned_too_few_test_positives +7731,35372,18.007492,0.92871094,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.92871094,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,17.0,0.0,1.0,ABC permease N-tail/TM1 signal,True,assigned_too_few_test_positives +7732,37690,16.403004,0.7998047,Ankyrin repeat,interpro,82608,Ankyrin repeat-containing domain,0.78759766,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.8381587301587301,0.013821762680784645,0.0031014621178555605,,4.456531195790135,0.0,17.0,0.0,1.0,N-terminal leaders and glycine-rich starts,True,assigned_and_evaluated +7733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Edge-of-domain accessory segment,False,no_term_above_threshold +7734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Autoproteolysis and protease-sensitive linkers,False,no_term_above_threshold +7735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal helical interfaces,False,no_term_above_threshold +7736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-TM1 extracellular loop,False,no_term_above_threshold +7737,85664,24.110676,0.9897461,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9897461,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycine-rich phosphate-engaging lid,True,assigned_too_few_test_positives +7738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop-helix element,False,no_term_above_threshold +7739,81858,22.826262,0.8041992,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8041992,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Alpha-helical transmembrane segments,True,assigned_too_few_test_positives +7740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CRHFY-like dehydratase motif,False,no_term_above_threshold +7741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed acidic functional patches,False,no_term_above_threshold +7742,85712,16.031548,0.94189453,3.40.630.30,gene3d,85712,3.40.630.30,0.94189453,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,15.0,0.0,1.0,Thioredoxin C-terminal Glu motif,True,assigned_too_few_test_positives +7743,84152,19.547653,0.8300781,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8300781,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,Amidohydrolase N-terminal substrate hotspot,True,assigned_too_few_test_positives +7744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-solenoid repeats,False,no_term_above_threshold +7745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical iron metallocenter signature,False,no_term_above_threshold +7746,88252,16.698204,0.89404297,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8881836,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.8568464397872204,0.04110981442495112,0.012405848471422242,,3.3137446841826668,0.0,16.0,0.0,1.0,Scattered beta-strand/loop peaks,True,assigned_and_evaluated +7747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-decorated adhesive beta patches,False,no_term_above_threshold +7748,38317,17.507917,0.8964844,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8964844,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8983809523809523,0.016351206942978366,0.0031014621178555605,,5.272096295757453,0.0,16.0,0.0,1.0,C-terminal domain-closing interface,True,assigned_and_evaluated +7749,87601,17.76105,0.60546875,Hydrolase,keyword,87601,Hydrolase,0.60546875,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.7119072687568242,0.12892750060071612,0.05316792202038104,0.008333333333333333,2.4249114071318023,16.0,18.0,9.941182600721149,4.903417123631102e-15,Acidic catalytic beta-strand,True,assigned_and_evaluated +7750,85762,31.68952,0.81689453,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.7998047,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,15.0,15.0,205.58965517241379,7.110790058883305e-35,FAD-dependent monooxygenase core,True,assigned_too_few_test_positives +7751,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short exposed interface segments,False,no_term_above_threshold +7752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C3/A2M bait-cleavage sensor,False,no_term_above_threshold +7753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sestrin/AhpD and HAD fold recognizer,False,no_term_above_threshold +7754,36091,15.6362095,0.9604492,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9423828,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,14.0,0.0,1.0,Conserved central beta-sheet residues,True,assigned_too_few_test_positives +7755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping loops,False,no_term_above_threshold +7756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich extracellular attachment regions,False,no_term_above_threshold +7757,47717,18.371275,0.9995117,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7441406,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,16.0,17.0,257.4031300593632,6.636301916524782e-38,DExD/H helicase motif II,True,assigned_too_few_test_positives +7758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphoinositide kinase/PX phosphate sensor,False,no_term_above_threshold +7759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed ectodomain segments,False,no_term_above_threshold +7760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse activation in small proteins,False,no_term_above_threshold +7761,55053,16.690886,0.8847656,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.8847656,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,14.0,0.0,1.0,Glycosyltransferase catalytic core,True,assigned_too_few_test_positives +7762,46079,36.797363,0.98095703,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98095703,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9551110654051831,0.41899890757608466,0.0057598582188746125,0.15384615384615385,72.74465649224793,14.0,17.0,76.71819852941177,4.678124818206397e-25,Regulatory linker helix,True,assigned_and_evaluated +7763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma70 σ2 RNAP-binding helix,False,no_term_above_threshold +7764,88009,25.042706,0.6586914,Repeat,keyword,88009,Repeat,0.6586914,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7388638667800915,0.24124619860764504,0.07266282676118742,,3.320077257667408,16.0,19.0,7.465748385834474,1.0353113695623046e-12,Modular repeat-rich proteins,True,assigned_and_evaluated +7765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site rim segments,False,no_term_above_threshold +7766,37894,17.885029,0.7426758,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7426758,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase helix-loop junction,True,assigned_too_few_test_positives +7767,49230,29.854782,0.9916992,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,15.0,16.0,263.6541863207547,9.583108103019209e-36,Acetyltransferase core amphipathic helix scaffold,True,assigned_too_few_test_positives +7768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-TM1 juxtamembrane region,False,no_term_above_threshold +7769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SH3-binding proline-rich IDRs,False,no_term_above_threshold +7770,46929,26.992212,0.99658203,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.87646484,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9995559502664298,0.71,0.002215330084182543,1.0,320.494,13.0,17.0,65.69528733683674,4.041586352124096e-22,RING-like E3 zinc fingers,True,assigned_and_evaluated +7771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scattered weak residue activations,False,no_term_above_threshold +7772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GyrA/ParC CTD hotspot,False,no_term_above_threshold +7773,47128,27.284557,0.94970703,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.94970703,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,7.0,15.0,119.92729885057472,1.7420350359475075e-13,Conserved noncatalytic glycine-rich beta-turn motifs,True,assigned_too_few_test_positives +7774,32561,16.072952,0.8178711,"proton-transporting ATPase activity, rotational mechanism",go_mf,32561,"proton-transporting ATPase activity, rotational mechanism",0.8178711,35,go,GO:0046961,go_mf:go:GO:0046961,,,,,,,,0.0,20.0,0.0,1.0,Charged coiled-coil/amphipathic helices,True,assigned_too_few_test_positives +7775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal AXP-binding segment,False,no_term_above_threshold +7776,36091,20.152794,0.99902344,GNAT domain,interpro,45290,Protein kinase-like domain superfamily,0.96435547,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,14.0,15.0,352.1915611814346,3.6675510776254767e-35,Conserved GNAT beta-strand motif,True,assigned_too_few_test_positives +7777,64058,23.227648,0.94970703,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9404297,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9988854213107445,0.7223735414911884,0.006202924235711121,1.0,116.45693451040087,3.0,19.0,17.999698098017507,0.0010374900821491326,Cofactor-adjacent Rossmann turns,True,assigned_and_evaluated +7778,64585,17.834288,0.9995117,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.99902344,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,8.0,18.0,301.1161616161616,1.7536810175315406e-18,RNA-regulatory CCCH zinc fingers,True,assigned_too_few_test_positives +7779,38873,15.7824545,0.82421875,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.67041016,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9903197158081706,0.48299663299663304,0.002215330084182543,0.4,218.02468013468015,10.0,10.0,171.32471264367817,1.12424031081604e-22,ABC signature-adjacent helix,True,assigned_and_evaluated +7780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-rich disordered regions,False,no_term_above_threshold +7781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helical bundles,False,no_term_above_threshold +7782,30398,19.126497,0.7265625,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.6894531,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6743705982352466,0.08740882142521485,0.004873726185201595,,17.93470090515545,17.0,20.0,61.20513285024154,8.732316527659777e-29,Active-site-adjacent amphipathic helix,True,assigned_and_evaluated +7783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ribokinase/pfkB phosphate-binding loop,False,no_term_above_threshold +7784,82029,32.051193,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99121094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS mid-helix packing hotspots,True,assigned_too_few_test_positives +7785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory region detector,False,no_term_above_threshold +7786,81799,19.297318,0.8515625,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6020508,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,0.0,20.0,0.0,1.0,Amphipathic Sensor-2 helical lid,True,assigned_too_few_test_positives +7787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha-helices,False,no_term_above_threshold +7788,85664,24.208231,0.98046875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98046875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,16.0,16.0,331.22777777777776,2.1521342125337958e-40,Glycosyltransferase donor-binding elements,True,assigned_too_few_test_positives +7789,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase ligase GTase core,False,no_term_above_threshold +7790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interaction scaffold,False,no_term_above_threshold +7791,37640,23.934582,0.9873047,EF-hand domain,interpro,46081,EF-hand domain pair,0.9819336,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,3.0,18.0,49.93383584589615,5.323000619292607e-05,Acidic metal-binding loops,True,assigned_too_few_test_positives +7792,72011,23.40504,0.99853516,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9477539,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,6.0,17.0,208.3436225975539,5.522869925408982e-13,Adenylation domain AMP-binding site,True,assigned_too_few_test_positives +7793,37446,26.323896,0.8847656,F-box domain,interpro,37446,F-box domain,0.8847656,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9913650793650793,0.1821832564443402,0.0031014621178555605,,58.74108711355369,7.0,18.0,90.5700954861111,1.6701213270352233e-12,Broad non-catalytic region activation,True,assigned_and_evaluated +7794,88058,31.927275,0.6274414,Signal,keyword,88058,Signal,0.6274414,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6322833285207784,0.2441497860539204,0.09127159946832078,0.18932038834951456,2.6749809083674676,10.0,18.0,4.002752601544143,7.277043587799096e-05,Extracytoplasmic beta loop linkers,True,assigned_and_evaluated +7795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal/leader and TM1,False,no_term_above_threshold +7796,36886,20.37464,0.9584961,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9584961,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9321365051133838,0.6967363560601265,0.003544528134692069,0.75,196.5667444534632,19.0,19.0,233.80784313725488,9.641649479262281e-45,Zn2C6 activation domains,True,assigned_and_evaluated +7797,87913,18.870434,0.8935547,Phosphopantetheine,keyword,64148,Winged helix DNA-binding domain superfamily,0.7817383,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8017164511814533,0.06386049615432901,0.006202924235711121,,10.295224272880041,0.0,17.0,0.0,1.0,Pre-HTH N-terminal amphipathic helix,True,assigned_and_evaluated +7798,88181,16.23938,0.69628906,Ubl conjugation pathway,keyword,88181,Ubl conjugation pathway,0.69628906,158,keywords,Ubl conjugation pathway,keyword:keywords:Ubl conjugation pathway,23.0,2257.0,0.817533377447355,0.30012563757857436,0.0101905183872397,0.21739130434782608,29.451459304993143,8.0,14.0,31.0566480010418,7.419971682065816e-11,Terminal acidic UIM-like helices,True,assigned_and_evaluated +7799,49116,23.337633,0.8569336,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8569336,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8950710479573712,0.2975018895462483,0.002215330084182543,0.4,134.2923529411765,10.0,20.0,43.518978102189784,1.4475001995303197e-14,Alpha-helical repeat scaffolds,True,assigned_and_evaluated +7800,87489,23.900394,0.8696289,GPI-anchor,keyword,87522,Glycoprotein,0.63378906,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8431746031746032,0.08579466725276724,0.0031014621178555605,,27.66265199849938,0.0,19.0,0.0,1.0,C-terminal membrane anchor and tail,True,assigned_and_evaluated +7801,85364,18.71854,0.75390625,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.75390625,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,19.0,190.1786283891547,1.9468739952274682e-25,Acidic cleft-edge binding loops,True,assigned_too_few_test_positives +7802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Pro-rich regulatory IDRs,False,no_term_above_threshold +7803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop-strand domain cap,False,no_term_above_threshold +7804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CpcD-like RxS(G/N)S loop motif,False,no_term_above_threshold +7805,43583,17.808435,0.94677734,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.94677734,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,12.0,12.0,416.9300699300699,9.458920012592666e-32,Catalytic histidine neighborhood,True,assigned_and_evaluated +7806,64148,16.361982,0.6333008,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.63183594,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6447838765815344,0.13970047900160065,0.008418254319893664,,16.594946374032247,3.0,19.0,14.050510604870384,0.0020955033506693506,Whole-protein activation on regulatory scaffolds,True,assigned_and_evaluated +7807,46082,24.37695,0.96240234,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.96240234,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9970793650793651,0.3556172119197329,0.0031014621178555605,,114.66114961469101,11.0,18.0,92.24064697609002,7.405598884776778e-20,PI-module-adjacent disordered linkers,True,assigned_and_evaluated +7808,64026,16.992218,0.82910156,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.6298828,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7778024581667407,0.012261506204610079,0.002658396101019052,,4.612369917300825,0.0,14.0,0.0,1.0,Basic-flanked C-terminal TM helix,True,assigned_and_evaluated +7809,49116,23.835506,0.9824219,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9824219,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9996447602131439,0.8528571428571428,0.002215330084182543,1.0,384.9797142857143,19.0,19.0,87.03795620437957,6.605101239071875e-37,Alpha-solenoid hydrophobic ladder,True,assigned_and_evaluated +7810,47529,29.589098,0.96777344,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.96777344,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9638833110218652,0.5508921157593646,0.007089056269384138,0.8125,77.71021907930538,16.0,19.0,65.11953034336815,1.6340624439516e-27,Repeating ectodomain β-sandwich motif,True,assigned_and_evaluated +7811,42974,15.903079,0.9042969,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.84814453,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9218412698412699,0.18116868959960292,0.0031014621178555605,,58.41396177518625,0.0,16.0,0.0,1.0,Histidine kinase DHp helix hydrophobes,True,assigned_and_evaluated +7812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclase-flanking cytosolic segments,False,no_term_above_threshold +7813,81685,22.833914,0.96240234,Transferase(Phosphotransferase) domain 1,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.96240234,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9565330363771344,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,15.0,15.0,85.66235632183908,3.186653641792077e-29,Kinase C-lobe hydrophobic spine,True,assigned_and_evaluated +7814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered peptide segments,False,no_term_above_threshold +7815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-rich recognition domains,False,no_term_above_threshold +7816,52236,30.788588,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.97021484,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,16.0,223.29962546816478,1.0796101345399494e-37,TPR repeat register marker,True,assigned_too_few_test_positives +7817,37640,23.355324,0.9838867,EF-hand domain,interpro,46081,EF-hand domain pair,0.95751953,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,16.0,0.0,1.0,Ca2+-binding loop motifs,True,assigned_too_few_test_positives +7818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low complexity regulatory IDRs,False,no_term_above_threshold +7819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage and viral structural proteins,False,no_term_above_threshold +7820,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site scaffold helices,False,no_term_above_threshold +7821,87108,24.551905,0.9370117,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.92626953,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9463473705021748,0.03895640149138681,0.003987594151528578,,9.769399796228893,0.0,13.0,0.0,1.0,Helices adjacent to functional loops,True,assigned_and_evaluated +7822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemoreceptor transducer coiled-coil,False,no_term_above_threshold +7823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic DNA-binding regions,False,no_term_above_threshold +7824,52236,18.759737,0.9716797,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.95410156,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,0.0,18.0,0.0,1.0,Short charge-rich helical motifs,True,assigned_too_few_test_positives +7825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed extracellular interaction regions,False,no_term_above_threshold +7826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal effector interaction surfaces,False,no_term_above_threshold +7827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered and surface interaction patches,False,no_term_above_threshold +7828,85669,16.169348,0.73291016,3.40.50.2300,gene3d,85669,3.40.50.2300,0.73291016,62,gene3d,3.40.50.2300,gene3d:gene3d:3.40.50.2300,5.0,2257.0,0.7968916518650089,0.4324650794020941,0.002215330084182543,0.4,195.21473684210528,15.0,16.0,238.8661858974359,4.2599805974581937e-35,Hydrophobic ligand-binding helices,True,assigned_and_evaluated +7829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-edge pocket micro-motif,False,no_term_above_threshold +7830,46277,16.40876,0.9082031,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9082031,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9561644944547883,0.07234660082310079,0.004873726185201595,,14.844207096158046,5.0,13.0,72.33802475127396,1.0367410698590997e-08,Beta-sheet core hydrophobics,True,assigned_and_evaluated +7831,31094,16.731985,0.9506836,phosphopantetheine binding,go_mf,43643,Phosphopantetheine binding ACP domain,0.8129883,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9456608811748999,0.30070748550539395,0.004430660168365086,,67.86967947856742,0.0,12.0,0.0,1.0,Secretory CAZyme catalytic cores,True,assigned_and_evaluated +7832,38873,15.660618,0.7167969,AAA+ ATPase domain,interpro,30398,ATP hydrolysis activity,0.6982422,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.797424511545293,0.475886132033673,0.002215330084182543,0.4,214.81500000000003,14.0,15.0,159.90306513409962,2.354085876269867e-30,ABC NBD C-motif,True,assigned_and_evaluated +7833,85649,16.979895,0.88378906,Vaccinia Virus protein VP39,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.83251953,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9054824646763457,0.08262024790335312,0.0101905183872397,,8.107560848602956,0.0,17.0,0.0,1.0,Kinase activation segment loops,True,assigned_and_evaluated +7834,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SH3/PTB/SH3b beta-strand/loop,False,no_term_above_threshold +7835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat solenoid/propeller termini hotspots,False,no_term_above_threshold +7836,88160,18.043924,0.8227539,Transmembrane beta strand,keyword,25167,cell outer membrane,0.69873047,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,16.0,235.15564320388347,1.4007539360355413e-29,Gram-negative secretion/assembly modules,True,assigned_too_few_test_positives +7837,85649,40.20174,0.97558594,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97265625,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8883461134249347,0.7082251237857922,0.0101905183872397,0.782608695652174,69.49843932106664,15.0,16.0,103.70071892393321,1.0701690889352076e-29,Methyltransferase active site helix,True,assigned_and_evaluated +7838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic cores and interfaces,False,no_term_above_threshold +7839,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical interaction surfaces and linkers,False,no_term_above_threshold +7840,87586,15.711675,0.6723633,Host membrane,keyword,88161,Transmembrane helix,0.671875,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.5943876308741174,0.02582670921187955,0.01639344262295082,,1.5754292619246524,0.0,20.0,0.0,1.0,Extracytosolic juxtamembrane flexible linker,True,assigned_and_evaluated +7841,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic charged linker helices,False,no_term_above_threshold +7842,83419,19.266975,0.9926758,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.97998047,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,14.0,18.0,282.75542005420056,1.0804839820255848e-32,Lectin carbohydrate-binding surface,True,assigned_too_few_test_positives +7843,85656,17.043407,0.8486328,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.8461914,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9508571428571428,0.03508127984792989,0.0031014621178555605,,11.311206945253966,0.0,18.0,0.0,1.0,Cofactor-positioning glycine-rich N-caps,True,assigned_and_evaluated +7844,81540,16.892288,0.9741211,"Tetracycline Repressor, domain 2",gene3d,81685,Transferase(Phosphotransferase) domain 1,0.94970703,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,0.0,15.0,0.0,1.0,Histidine kinase CA F-helix,True,assigned_too_few_test_positives +7845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic glycine-rich interface patches,False,no_term_above_threshold +7846,37690,22.376293,0.97802734,Ankyrin repeat,interpro,88009,Repeat,0.6958008,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9931428571428571,0.360858189429618,0.0031014621178555605,0.2857142857142857,116.35099050609254,3.0,14.0,38.71493506493506,0.00010724000485607927,N-terminal solenoid nucleator,True,assigned_and_evaluated +7847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,L-type lectin CRD,False,no_term_above_threshold +7848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered termini and linkers,False,no_term_above_threshold +7849,36886,25.127993,0.99072266,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.99072266,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9349710982658959,0.5643121136358842,0.003544528134692069,0.75,159.20655505952382,18.0,18.0,233.80784313725488,1.5159322438572416e-42,Fungal C-terminal regulatory tails,True,assigned_and_evaluated +7850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial N-terminal HTH DNA-binding domain,False,no_term_above_threshold +7851,38317,18.379637,0.96972656,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.96972656,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.941936507936508,0.03024139431478684,0.0031014621178555605,,9.750689566924843,0.0,12.0,0.0,1.0,ATP-binding core constellation,True,assigned_and_evaluated +7852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular/cytosolic non-TM domains,False,no_term_above_threshold +7853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +7854,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interfacial lipid-binding helices,False,no_term_above_threshold +7855,63831,22.182737,0.9707031,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9707031,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9472826891751814,0.026678585012063643,0.002658396101019052,,10.035594395371273,0.0,17.0,0.0,1.0,Solvent-exposed helical polar residues,True,assigned_and_evaluated +7856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic TM-helix boundary motif,False,no_term_above_threshold +7857,50806,22.010527,0.8154297,"Homeobox, conserved site",interpro,37071,Homeodomain,0.7861328,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,Cytosolic nucleotide-binding hydrophobic scaffolds,True,assigned_too_few_test_positives +7858,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral structural polyprotein detector,False,no_term_above_threshold +7859,63960,31.083227,0.92089844,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.92089844,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,17.0,17.0,193.57467532467533,6.347107800690125e-39,N-terminal FAD-binding loop,True,assigned_too_few_test_positives +7860,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic partner-interaction domains,False,no_term_above_threshold +7861,88161,44.10589,0.6123047,Transmembrane helix,keyword,88161,Transmembrane helix,0.6123047,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5897560212699406,0.3128795171171064,0.1847585290208241,0.22302158273381295,1.6934510075139306,16.0,16.0,5.4274920345926265,3.815160537588821e-12,Charged N-terminal juxtamembrane tails,True,assigned_and_evaluated +7862,87326,19.377682,0.6142578,Coiled coil,keyword,87326,Coiled coil,0.6142578,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6668083253866247,0.2078661077856611,0.03943287549844927,0.15730337078651685,5.271391070474574,10.0,17.0,7.416192952122698,2.2143391165396207e-07,SP/TP-rich acidic IDR tails,True,assigned_and_evaluated +7863,64148,25.649118,0.74365234,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.74365234,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.7249188655284323,0.1977636267619578,0.008418254319893664,0.10526315789473684,23.49223713693362,14.0,17.0,73.2830553116769,8.837554555530104e-25,C-terminal regulatory metal-sensing tails,True,assigned_and_evaluated +7864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral nucleic-acid engagement regions,False,no_term_above_threshold +7865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ERAD–p97 UBL/UBX proteostasis,False,no_term_above_threshold +7866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane coiled-coil stalks,False,no_term_above_threshold +7867,38654,19.746513,0.8803711,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.87646484,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,17.0,0.0,1.0,Mid-to-C-terminal active-site flanking segments,True,assigned_too_few_test_positives +7868,24907,15.758392,0.7138672,extracellular space,go_cc,88058,Signal,0.67041016,241,go,GO:0005615,go_cc:go:GO:0005615,18.0,2257.0,0.6569152895637933,0.07233271942283777,0.007975188303057155,,9.069719318741381,3.0,15.0,7.44797001873829,0.011835644456598774,Signal-peptide junction N-terminus,True,assigned_and_evaluated +7869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adhesion receptor ectodomain activation,False,no_term_above_threshold +7870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interfacing helices and lipase motifs,False,no_term_above_threshold +7871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket lining,False,no_term_above_threshold +7872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenylation domain motif detector,False,no_term_above_threshold +7873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peri-catalytic metal-associated segments,False,no_term_above_threshold +7874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oligomeric coiled-coil helices,False,no_term_above_threshold +7875,64168,19.031286,0.7080078,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.7080078,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.5974245115452931,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,11.0,11.0,334.9494382022472,4.187587980531753e-28,P-type ATPase cytosolic headpiece,True,assigned_and_evaluated +7876,48883,20.318422,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,18.0,18.0,480.8145161290322,6.533334885052963e-48,PLP-lysine attachment motif,True,assigned_too_few_test_positives +7877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged boundary interaction patches,False,no_term_above_threshold +7878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal extracytoplasmic disorder,False,no_term_above_threshold +7879,69819,28.827347,0.8671875,"ATPase, nucleotide binding domain",interpro,69819,"ATPase, nucleotide binding domain",0.8671875,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,13.0,18.0,303.2366979655712,1.4877486913463804e-30,Downstream helical coupling lids,True,assigned_too_few_test_positives +7880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity ATPase-adjacent linkers,False,no_term_above_threshold +7881,49116,24.998413,0.984375,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.984375,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,18.0,18.0,87.03795620437957,5.040547535858956e-35,Periodic HEAT repeat pattern,True,assigned_and_evaluated +7882,36914,28.894657,0.99853516,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9116211,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,13.0,0.0,1.0,Conserved nucleotide handling scaffolds,True,assigned_too_few_test_positives +7883,87409,17.433893,0.74365234,Dioxygenase,keyword,87409,Dioxygenase,0.74365234,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,10.0,11.0,254.46436192915064,8.756408854128775e-24,Fe2OG pre-core activation peak,True,assigned_too_few_test_positives +7884,87601,17.195093,0.6347656,Hydrolase,keyword,87601,Hydrolase,0.6347656,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.5520238652316332,0.06475402411537873,0.05316792202038104,,1.2179152702367482,7.0,14.0,5.591915212905646,0.00016174872815778385,"Helix N-caps, β→α junctions",True,assigned_and_evaluated +7885,39971,20.220146,0.89941406,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,39971,"Calcineurin-like phosphoesterase domain, ApaH type",0.89941406,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,19.0,0.0,1.0,Active-site-adjacent glycine hinge,True,assigned_too_few_test_positives +7886,87970,18.00602,0.8310547,Protein phosphatase,keyword,87970,Protein phosphatase,0.8310547,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,15.0,16.0,270.0226449275362,6.736102294813504e-36,Flank-biased Cys-phosphatase activation,True,assigned_too_few_test_positives +7887,85672,18.863136,0.76464844,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7480469,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8734804142278254,0.08461382181759872,0.01595037660611431,,5.3048165511755645,0.0,18.0,0.0,1.0,Nucleotide pyrophosphate-binding residues,True,assigned_and_evaluated +7888,37312,21.248901,0.9814453,"DNA-binding HTH domain, TetR-type",interpro,37312,"DNA-binding HTH domain, TetR-type",0.9814453,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,14.0,0.0,1.0,Catalytic domain aromatic helix-cap,True,assigned_too_few_test_positives +7889,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic/OM mature-chain activation,False,no_term_above_threshold +7890,38317,16.92831,0.7895508,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7895508,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.5768888888888888,0.004511096333437164,0.0031014621178555605,,1.4545063463668113,0.0,17.0,0.0,1.0,C-terminal sheet-edge β–α motif,True,assigned_and_evaluated +7891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short localized secondary-structure segments,False,no_term_above_threshold +7892,45290,35.8168,0.9682617,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9682617,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.960492938434115,0.9017251172988876,0.0057598582188746125,0.9230769230769231,156.55335305719916,14.0,14.0,73.42487684729065,2.1479968934241087e-26,Kinase beta3 ATP-binding lysine motif,True,assigned_and_evaluated +7893,42974,15.834488,0.93896484,"Serine/threonine-protein kinase, active site",interpro,87108,ANK repeat,0.80810547,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9973333333333333,0.3716854573997431,0.0031014621178555605,,119.84201105017432,0.0,18.0,0.0,1.0,HATPase_c ATP-pocket helix,True,assigned_and_evaluated +7894,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PH-flanking regulatory IDRs,False,no_term_above_threshold +7895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal EMI disulfide loop,False,no_term_above_threshold +7896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic alpha/beta scaffold cores,False,no_term_above_threshold +7897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta core polyanion-binding surfaces,False,no_term_above_threshold +7898,52941,24.556679,0.99072266,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9770508,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,18.0,245.88961669092672,6.9613297944377155e-40,MFS TM1 periplasmic gate,True,assigned_too_few_test_positives +7899,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical lid over pocket,False,no_term_above_threshold +7900,37020,17.99661,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,13.0,15.0,707.8292237442922,2.6601955039034077e-36,Glycosyltransferase donor-lid helix,True,assigned_too_few_test_positives +7901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic globular ectodomains,False,no_term_above_threshold +7902,85672,40.991844,0.78564453,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7841797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7112224223322827,0.29584598450457306,0.01595037660611431,0.25,18.54789963963393,10.0,10.0,40.01409395973155,2.2135838633896868e-16,P-loop NTPase switch loop,True,assigned_and_evaluated +7903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arginine-rich polybasic patches,False,no_term_above_threshold +7904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Whole-sequence activation with metal-site peaks,False,no_term_above_threshold +7905,85364,27.027586,0.9589844,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9589844,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,10.0,17.0,177.1271538918598,6.588426341701926e-21,Loop-helix hinge switches,True,assigned_too_few_test_positives +7906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metallopeptidase substrate-binding cleft,False,no_term_above_threshold +7907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge mixed secondary surface segment,False,no_term_above_threshold +7908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Perimembrane loops and termini,False,no_term_above_threshold +7909,35372,20.950964,0.9355469,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9355469,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,15.0,16.0,657.5845588235294,9.455180686344042e-42,Transporter transmembrane helices,True,assigned_too_few_test_positives +7910,63951,18.736017,0.96533203,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9628906,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9963177145116647,0.5606738886449032,0.003987594151528578,0.6666666666666666,140.60455185239405,4.0,17.0,37.9147853736089,6.16161471053209e-06,Extracellular aromatic beta-strands,True,assigned_and_evaluated +7911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short solvent-exposed interaction motifs,False,no_term_above_threshold +7912,64155,18.351545,0.7758789,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.75878906,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,10.0,11.0,252.09725158562367,9.609551158347564e-24,RNase H-like catalytic scaffold,True,assigned_too_few_test_positives +7913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse mature chain activation,False,no_term_above_threshold +7914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rap-family TPR regulatory module,False,no_term_above_threshold +7915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SET/PR AdoMet-binding fold,False,no_term_above_threshold +7916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand-capping linker loops,False,no_term_above_threshold +7917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycan-binding surfaces,False,no_term_above_threshold +7918,63951,20.343903,0.97021484,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9667969,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9965895610913404,0.39717716298176065,0.003987594151528578,0.7777777777777778,99.6032063166482,11.0,20.0,88.62581081081082,1.853804103004057e-19,Glycosylated extracellular beta-strand loops,True,assigned_and_evaluated +7919,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-sensing helix–loop–β junctions,False,no_term_above_threshold +7920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase binding groove,False,no_term_above_threshold +7921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered termini activation peaks,False,no_term_above_threshold +7922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IPP isomerase FMN-adjacent Pro motif,False,no_term_above_threshold +7923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Recombinase DNA-binding HTH,False,no_term_above_threshold +7924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity flanks,False,no_term_above_threshold +7925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FBA GGxW regional activation,False,no_term_above_threshold +7926,64620,17.291178,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.98339844,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,15.0,15.0,324.0271739130435,8.124483338465097e-38,ATP-proximal beta-loop motif,True,assigned_too_few_test_positives +7927,64507,33.176277,0.9946289,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9946289,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat helix-A consensus site,True,assigned_and_evaluated +7928,85664,19.561975,0.9765625,Glycogen Phosphorylase B;,gene3d,63831,F-box-like domain superfamily,0.89208984,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,C-terminal amphipathic helix in glycosyltransferases,True,assigned_too_few_test_positives +7929,82597,16.460012,0.7519531,Tetratricopeptide repeat domain,gene3d,82597,Tetratricopeptide repeat domain,0.7519531,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.7399218428630193,0.05017167903940321,0.0057598582188746125,,8.710575353225618,0.0,20.0,0.0,1.0,Scaffold C-terminal SLiM regions,True,assigned_and_evaluated +7930,64148,19.522133,0.8442383,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.8442383,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9144795635200601,0.1316896253016602,0.008418254319893664,,15.643341279255111,2.0,16.0,11.123320895522388,0.02313564062834663,Short polar capping linkers,True,assigned_and_evaluated +7931,84879,18.623245,0.8803711,"Histidine kinase-like ATPase, C-terminal domain",gene3d,84879,"Histidine kinase-like ATPase, C-terminal domain",0.8803711,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,17.0,17.0,327.5879120879121,1.027565445798913e-42,HATPase_c helix hydrophobic motif,True,assigned_too_few_test_positives +7932,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic core packing,False,no_term_above_threshold +7933,45714,15.567751,0.69970703,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.69970703,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,10.0,0.0,1.0,TM1-TM2 hairpin motif,True,assigned_too_few_test_positives +7934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop hairpins,False,no_term_above_threshold +7935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal structural interface helices,False,no_term_above_threshold +7936,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal substrate-binding interface patches,False,no_term_above_threshold +7937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered charged alpha-helix detector,False,no_term_above_threshold +7938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme-terminal IDR activation,False,no_term_above_threshold +7939,36354,17.860117,0.92285156,RNA recognition motif domain,interpro,88001,RNA-binding,0.67578125,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,8.0,17.0,100.92424883622513,1.0992122327556614e-14,Disordered arginine-rich RGG/GAR tails,True,assigned_too_few_test_positives +7940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Smr beta-strand TGxG motif,False,no_term_above_threshold +7941,36499,19.469183,0.99853516,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.99853516,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,9.0,17.0,404.6674208144796,4.598782552307068e-22,Disordered linker-biased activation,True,assigned_too_few_test_positives +7942,87856,16.852915,0.75439453,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.75439453,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5288406075754662,0.08294828786632065,0.012405848471422242,0.07142857142857142,6.686224489795918,17.0,17.0,84.68892045454545,6.275870931909337e-33,Nucleotide-handling catalytic modules,True,assigned_and_evaluated +7943,81858,18.73223,0.88671875,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6435547,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Transmembrane helix capping motifs,True,assigned_too_few_test_positives +7944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-B nucleotide-sugar donor lobe,False,no_term_above_threshold +7945,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent binding face,False,no_term_above_threshold +7946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged noncatalytic coupling linkers,False,no_term_above_threshold +7947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosyltransferase luminal domains and GT-A,False,no_term_above_threshold +7948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Cysteine clusters, disordered acidic tails",False,no_term_above_threshold +7949,82029,17.293886,0.9277344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.86865234,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,15.0,0.0,1.0,Juxtamembrane aromatic anchor motifs,True,assigned_too_few_test_positives +7950,46082,17.359354,0.9511719,PH-like domain superfamily,interpro,87697,Knottin,0.71728516,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9906031746031746,0.21795074295074296,0.0031014621178555605,,70.27354669140384,0.0,17.0,0.0,1.0,Jelly-roll pocket beta-strands,True,assigned_and_evaluated +7951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical domain core activation,False,no_term_above_threshold +7952,36104,22.92879,0.8964844,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8964844,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,ALDH C-terminal catalytic core,True,assigned_too_few_test_positives +7953,59224,32.94462,0.79785156,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.79785156,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7833650793650794,0.46799586471717614,0.0031014621178555605,0.5714285714285714,150.89523809523808,17.0,18.0,129.74359959037378,3.115927601669942e-35,Serine lipase catalytic core,True,assigned_and_evaluated +7954,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic C-terminal tails,False,no_term_above_threshold +7955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic interhelical loop linkers,False,no_term_above_threshold +7956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-anchoring helices,False,no_term_above_threshold +7957,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal strand-to-helix motif,False,no_term_above_threshold +7958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged linear interaction tracts,False,no_term_above_threshold +7959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ferredoxin-like RNA/RNAP domains,False,no_term_above_threshold +7960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic hinge loop turns,False,no_term_above_threshold +7961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Retroviral RT Trp-repeat interface,False,no_term_above_threshold +7962,87149,25.526949,0.75146484,Amphibian defense peptide,keyword,87162,Antimicrobial,0.6748047,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8482823815932834,0.29672907851177055,0.012405848471422242,0.39285714285714285,23.918483221466648,0.0,20.0,0.0,1.0,Membrane-helix and peptide-maturation detector,True,assigned_and_evaluated +7963,63960,32.458626,0.84814453,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.84814453,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,19.0,19.0,193.57467532467533,3.1320939821269373e-43,Flavoenzyme C-terminal aromatic motif,True,assigned_too_few_test_positives +7964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structural beta strands,False,no_term_above_threshold +7965,48883,24.064108,0.94140625,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.94140625,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,14.0,14.0,480.8145161290322,8.741512687097007e-38,Type I PLP active-site core,True,assigned_too_few_test_positives +7966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transporter transmembrane helices,False,no_term_above_threshold +7967,37446,18.95328,0.9746094,F-box domain,interpro,37446,F-box domain,0.9746094,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9638412698412697,0.04371432953118282,0.0031014621178555605,,14.09474882169709,0.0,19.0,0.0,1.0,Alpha-helix N-cap capping residues,True,assigned_and_evaluated +7968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-binding loop-and-lid,False,no_term_above_threshold +7969,48767,22.390108,0.99560547,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99560547,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,14.0,0.0,1.0,Methyl-mark regulator flanks,True,assigned_too_few_test_positives +7970,59229,22.21229,0.7285156,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7285156,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8158499085282784,0.3143547848963356,0.0101905183872397,0.391304347826087,30.847771717870845,9.0,15.0,63.76577540106951,6.025202260904326e-15,MTase-adjacent disordered linkers,True,assigned_and_evaluated +7971,25169,15.8718605,0.74121094,pilus,go_cc,25169,pilus,0.74121094,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.885790408525755,0.05620343468043098,0.002215330084182543,,25.370230414746544,0.0,14.0,0.0,1.0,GatB core GYQIT motif,True,assigned_and_evaluated +7972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-termini and reverse transcriptases,False,no_term_above_threshold +7973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic RNA binding assembly surfaces,False,no_term_above_threshold +7974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C active-site lumenal/periplasmic loops,False,no_term_above_threshold +7975,64168,25.316504,0.96972656,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.96972656,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.7955595026642984,0.6008861320336729,0.002215330084182543,0.6,271.23999999999995,17.0,17.0,334.9494382022472,7.26757959387553e-43,HAD-like phosphatase cap domain,True,assigned_and_evaluated +7976,64475,16.039732,0.8339844,ACP-like superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8256836,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9170266008501302,0.4064491003484971,0.0057598582188746125,0.5384615384615384,70.56581688358138,1.0,14.0,38.023596938775505,0.04344145960883729,MTase acceptor-binding lid,True,assigned_and_evaluated +7977,36886,17.609896,0.87939453,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.72802734,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8665518008003558,0.16227405380855356,0.003544528134692069,,45.78156743073817,0.0,17.0,0.0,1.0,Fungal TF disordered tails,True,assigned_and_evaluated +7978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-scale catalytic core recognition,False,no_term_above_threshold +7979,64620,18.172022,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.98339844,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,19.0,19.0,324.0271739130435,2.7035397615707734e-47,GHKL ATP-lid glycine-rich loop,True,assigned_too_few_test_positives +7980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-box plug-domain marker,False,no_term_above_threshold +7981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/anchoring segments,False,no_term_above_threshold +7982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long coiled-coil assembly stalks,False,no_term_above_threshold +7983,32561,15.994748,0.8022461,"proton-transporting ATPase activity, rotational mechanism",go_mf,32561,"proton-transporting ATPase activity, rotational mechanism",0.8022461,35,go,GO:0046961,go_mf:go:GO:0046961,,,,,,,,5.0,19.0,166.9120940649496,2.0986342534611294e-10,Rpn/YAE1-LTO1 coiled-coil marker,True,assigned_too_few_test_positives +7984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fe-ADH mid-domain helices,False,no_term_above_threshold +7985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and disordered tails,False,no_term_above_threshold +7986,87857,27.666391,0.72753906,Nucleus,keyword,87857,Nucleus,0.72753906,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7083115472790896,0.1872947655097145,0.06247230837394772,0.0070921985815602835,2.998044579825714,17.0,19.0,5.42125053487377,1.3036411618123174e-11,Intrinsically disordered low-complexity regions,True,assigned_and_evaluated +7987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical packing residues,False,no_term_above_threshold +7988,85649,25.07493,0.95214844,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9448242,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9309875053520689,0.5008313829582144,0.0101905183872397,0.6956521739130435,49.14680136246477,0.0,9.0,0.0,1.0,Nucleotide-binding signature loops,True,assigned_and_evaluated +7989,36115,17.051851,0.79003906,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.78466797,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,14.0,0.0,1.0,Accessory helical DNA-binding modules,True,assigned_too_few_test_positives +7990,64058,21.319859,0.6542969,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.64697266,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6408827463218904,0.1996687554064603,0.006202924235711121,0.14285714285714285,32.189455782312926,16.0,16.0,113.99808795411089,4.441314123773332e-33,Oxidoreductase active-site β–α module,True,assigned_and_evaluated +7991,64620,20.252718,1.0,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,1.0,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,20.0,275.423097826087,9.054377679686673e-40,GHKL/HPt ATP-binding loop,True,assigned_too_few_test_positives +7992,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-propeller blade-loop recognition,False,no_term_above_threshold +7993,38317,21.660635,0.77001953,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.77001953,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6403174603174603,0.12126294913180158,0.0031014621178555605,0.14285714285714285,39.09863945578231,0.0,17.0,0.0,1.0,C-terminal TM transporters; AAA+ His,True,assigned_and_evaluated +7994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal binding interface segments,False,no_term_above_threshold +7995,63951,17.84819,0.86572266,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.83935547,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8060003954132067,0.09383015721690507,0.003987594151528578,,23.530518315394975,1.0,20.0,8.056891891891892,0.18832188981813525,Extracellular beta-strand folds,True,assigned_and_evaluated +7996,88058,53.847565,0.8339844,Signal,keyword,88058,Signal,0.8339844,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8402685405651045,0.3211962841086166,0.09127159946832078,,3.519126277830814,5.0,20.0,1.801238670694864,0.21355299572385222,Generic extreme N-terminus detector,True,assigned_and_evaluated +7997,38317,15.576323,0.9584961,Pentatricopeptide repeat,interpro,88009,Repeat,0.6582031,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8211746031746033,0.018412384778406503,0.0031014621178555605,,5.936678920694782,0.0,18.0,0.0,1.0,Helix-capping catalytic loops,True,assigned_and_evaluated +7998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intrinsic disorder/low-complexity detector,False,no_term_above_threshold +7999,46581,15.662276,0.9819336,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9819336,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,4.0,17.0,40.780437756497946,4.642615327602818e-06,Polar beta-strand edge clusters,True,assigned_too_few_test_positives +8000,88161,53.528374,0.6635742,Transmembrane helix,keyword,88161,Transmembrane helix,0.6635742,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7007194244604316,0.4674978686883052,0.1847585290208241,0.5059952038369304,2.5303182005503713,10.0,10.0,5.4274920345926265,8.904125403435288e-08,TRP-box gate-coupling segment,True,assigned_and_evaluated +8001,64003,22.271664,0.89941406,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.8666992,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9989620403321471,0.8838183421516754,0.003987594151528578,0.8888888888888888,221.64199980403683,17.0,17.0,130.4617067833698,4.534127311811392e-36,C2H2 TF C-terminal IDRs,True,assigned_and_evaluated +8002,36535,22.917833,0.95458984,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9536133,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9486648865153537,0.8793319549057254,0.004430660168365086,0.9,198.46522222222222,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Kinase C-lobe hydrophobic anchor,True,assigned_and_evaluated +8003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity kinase IDRs,False,no_term_above_threshold +8004,38317,19.31568,0.85546875,Pentatricopeptide repeat,interpro,63831,F-box-like domain superfamily,0.81396484,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8328253968253969,0.03410446629542242,0.0031014621178555605,,10.996254346966916,0.0,14.0,0.0,1.0,Terminal membrane targeting signals,True,assigned_and_evaluated +8005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical solenoid scaffolds,False,no_term_above_threshold +8006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cystatin/cathelin inhibitor domain,False,no_term_above_threshold +8007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining membrane hairpin module,False,no_term_above_threshold +8008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured C-terminal acidic patch,False,no_term_above_threshold +8009,85672,37.13296,0.95947266,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.94433594,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9556756215918756,0.6443989949746534,0.01595037660611431,0.7222222222222222,40.40023699049424,8.0,8.0,40.01409395973155,3.3458427790164747e-13,AAA+ core beta-sheet hydrophobics,True,assigned_and_evaluated +8010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane soluble domain activation,False,no_term_above_threshold +8011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Herpesvirus assemblin protease precursor,False,no_term_above_threshold +8012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NLR/karyopherin mid-C helix clusters,False,no_term_above_threshold +8013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Luminal/periplasmic domain activation,False,no_term_above_threshold +8014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Primase helicase N-terminal interface,False,no_term_above_threshold +8015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helical docking motifs,False,no_term_above_threshold +8016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P/S/T-rich disordered linkers,False,no_term_above_threshold +8017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amide hydrolase fold signature,False,no_term_above_threshold +8018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"S4 RNA-binding, Pol III delta",False,no_term_above_threshold +8019,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical signal/anchor motif,False,no_term_above_threshold +8020,48241,20.346422,0.9086914,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9086914,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,1.0,12.0,32.262445887445885,0.05084804566177454,ABC NBD Q-loop motif,True,assigned_too_few_test_positives +8021,59224,17.09328,0.9140625,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9140625,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.984,0.12216389068820907,0.0031014621178555605,,39.38912875475541,0.0,18.0,0.0,1.0,Extracellular exposed-loop activations,True,assigned_and_evaluated +8022,88160,17.65777,0.81396484,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.81396484,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,12.0,16.0,217.06674757281553,1.2053969020607763e-26,Outer-membrane β-barrel translocator loops,True,assigned_too_few_test_positives +8023,87697,23.807098,0.81152344,Knottin,keyword,88009,Repeat,0.6958008,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8211775450278607,0.08641234357786023,0.017279574656623838,,5.000837421928988,0.0,16.0,0.0,1.0,Periodic glycine in repeats,True,assigned_and_evaluated +8024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered zinc-finger linkers,False,no_term_above_threshold +8025,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble ligand-sensing hydrophobic helices,False,no_term_above_threshold +8026,38654,17.567951,0.7114258,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.7114258,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,13.0,0.0,1.0,Peripheral charged coiled-coil scaffolds,True,assigned_too_few_test_positives +8027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass membrane O-acetyltransferases,False,no_term_above_threshold +8028,38654,28.865583,0.9995117,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9863281,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,10.0,0.0,1.0,FAH superfamily catalytic core,True,assigned_too_few_test_positives +8029,87489,33.4158,0.94433594,GPI-anchor,keyword,87489,GPI-anchor,0.94433594,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9226984126984127,0.25868482425859474,0.0031014621178555605,,83.40737833594976,0.0,19.0,0.0,1.0,C-terminal cell-surface anchors,True,assigned_and_evaluated +8030,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic C-terminal TM helices,False,no_term_above_threshold +8031,81858,19.097818,0.9609375,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.9609375,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,16.0,16.0,261.4956140350877,9.006051383641506e-39,GPCR cytoplasmic loop-helix junctions,True,assigned_too_few_test_positives +8032,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding catalytic cores,False,no_term_above_threshold +8033,37314,17.385748,0.96191406,"Helicase, C-terminal domain-like",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.625,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,13.0,13.0,317.1329787234043,8.872044943575978e-33,RecA1-RecA2 coupling hinge,True,assigned_too_few_test_positives +8034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Ser-rich β–α active-site loop,False,no_term_above_threshold +8035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NagB C-terminal aromatic motif,False,no_term_above_threshold +8036,88160,16.253107,0.8564453,Transmembrane beta strand,keyword,25167,cell outer membrane,0.71728516,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,15.0,18.0,241.18527508090614,2.7942157140884263e-34,OMP beta-barrel extracellular loops,True,assigned_too_few_test_positives +8037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic helical lids and hotspots,False,no_term_above_threshold +8038,87857,18.989614,0.6074219,Nucleus,keyword,87857,Nucleus,0.6074219,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.5732078456608883,0.12999136548767662,0.06247230837394772,0.04964539007092199,2.0807837723807525,19.0,20.0,5.7560924796747965,5.183410498242789e-14,Disordered chromatin regulatory tails,True,assigned_and_evaluated +8039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding nucleic acid interface,False,no_term_above_threshold +8040,55053,21.947712,0.9848633,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9848633,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,14.0,14.0,552.0462962962963,1.2209404069247088e-38,NRPS C-domain activation,True,assigned_too_few_test_positives +8041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-catalytic capping/gating segments,False,no_term_above_threshold +8042,36552,17.637354,0.9536133,EGF-like domain,interpro,82716,Laminin,0.91308594,57,ip,IPR000742,interpro:ip:IPR000742,5.0,2257.0,0.999911190053286,0.9666666666666666,0.002215330084182543,1.0,436.3533333333333,20.0,20.0,286.63942307692304,1.569176841460289e-48,EGF-like loop glycine motif,True,assigned_and_evaluated +8043,36091,25.339678,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9995117,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,GNAT core beta-strand motif,True,assigned_too_few_test_positives +8044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,cNMP phosphate-binding pockets,False,no_term_above_threshold +8045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs and gating plugs,False,no_term_above_threshold +8046,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adjacent noncatalytic substrate binding exosites,False,no_term_above_threshold +8047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global flavin oxidoreductase activation,False,no_term_above_threshold +8048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-strand glycan-binding,False,no_term_above_threshold +8049,64058,18.493692,0.9111328,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8623047,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9711961021590981,0.1375503999787371,0.006202924235711121,,22.175089482286403,0.0,19.0,0.0,1.0,Catalytic domain distal clusters,True,assigned_and_evaluated +8050,88058,17.513878,0.60791016,Signal,keyword,88058,Signal,0.60791016,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6214385121158044,0.11179332650430879,0.09127159946832078,,1.2248424170884706,3.0,19.0,1.137624423596756,0.7800416838874774,Low-confidence intrinsic disorder,True,assigned_and_evaluated +8051,59229,46.567642,0.984375,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.984375,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8894846444280098,0.73101216384972,0.0101905183872397,0.782608695652174,71.73454146994861,18.0,18.0,106.27629233511585,1.4850343564104726e-36,SAM binding methyltransferase pocket,True,assigned_and_evaluated +8052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ATP-grasp nucleotide lobe,False,no_term_above_threshold +8053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted β-edge motifs,False,no_term_above_threshold +8054,85672,36.713104,0.87597656,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8730469,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8206388513682524,0.5121749869309548,0.01595037660611431,0.4722222222222222,32.1105262639768,17.0,17.0,40.01409395973155,1.7557395315514075e-27,Pre-motif II helicase connector,True,assigned_and_evaluated +8055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad activation excluding Cys/His chelators,False,no_term_above_threshold +8056,36354,15.56032,0.94628906,RNA recognition motif domain,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9316406,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,5.0,15.0,71.48800959232614,1.242376776460497e-08,Alanine-focused helical packing,True,assigned_too_few_test_positives +8057,36115,26.264017,0.9848633,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9760742,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,14.0,0.0,1.0,PAS-like sensory beta-sandwich,True,assigned_too_few_test_positives +8058,88161,28.262337,0.64453125,Transmembrane helix,keyword,88161,Transmembrane helix,0.64453125,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6938477478886456,0.38652478882983826,0.1847585290208241,0.33093525179856115,2.0920538330670144,14.0,14.0,5.4274920345926265,1.0920821671226735e-10,Hydrophobic transmembrane helical residues,True,assigned_and_evaluated +8059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical segment motif,False,no_term_above_threshold +8060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular ligand-binding beta loops,False,no_term_above_threshold +8061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundary loops,False,no_term_above_threshold +8062,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD coupling linkers,False,no_term_above_threshold +8063,88154,19.152222,0.8613281,Transit peptide,keyword,88154,Transit peptide,0.8613281,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.8261960740409016,0.03253463957152668,0.010633584404076208,,3.0596117297056544,7.0,19.0,10.756920459817515,3.6592997700234248e-06,Disordered N-terminal activation window,True,assigned_and_evaluated +8064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domains and acidic IDRs,False,no_term_above_threshold +8065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted glycosidase glycan-binding groove,False,no_term_above_threshold +8066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and collagen repeats,False,no_term_above_threshold +8067,88153,16.055258,0.63183594,Transferase,keyword,88153,Transferase,0.63183594,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.6697553670673134,0.1712131302031352,0.052724856003544526,0.07563025210084033,3.2472944106594634,2.0,17.0,1.3347736049700565,0.699462538305964,Active-site pocket-edge loops,True,assigned_and_evaluated +8068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RND adaptor C-terminal beta-strand motif,False,no_term_above_threshold +8069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic POTRA-like scaffolds,False,no_term_above_threshold +8070,87882,15.836292,0.79785156,Palmitate,keyword,88058,Signal,0.69189453,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.6343476973197097,0.004827992411668878,0.002658396101019052,,1.816129812189443,0.0,19.0,0.0,1.0,N-terminal secretion/docking SLiMs,True,assigned_and_evaluated +8071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase post-His DHp helix,False,no_term_above_threshold +8072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta alpha scaffold,False,no_term_above_threshold +8073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed charged loop/helix patch,False,no_term_above_threshold +8074,64594,19.462435,0.9765625,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,88150,Transcription regulation,0.63964844,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9922743441529568,0.20005952828533474,0.003544528134692069,,56.44179441750006,0.0,18.0,0.0,1.0,IDR TADs upstream of bZIP/bHLH,True,assigned_and_evaluated +8075,50807,16.108353,0.98535156,"Cytochrome P450, conserved site",interpro,36876,Cytochrome P450,0.98339844,26,ip,IPR017972,interpro:ip:IPR017972,8.0,2257.0,0.9994997776789685,0.8019345238095238,0.003544528134692069,1.0,226.2457775297619,9.0,19.0,237.32375055285274,8.649978877879318e-20,Charged proximal meander loop,True,assigned_and_evaluated +8076,59224,30.6151,0.97558594,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97558594,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Nucleophile motif beta-strand,True,assigned_and_evaluated +8077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail/sorting detector,False,no_term_above_threshold +8078,36354,17.21485,0.98583984,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.98583984,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,17.0,0.0,1.0,Helix C-terminal hydrophobic cap,True,assigned_too_few_test_positives +8079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphorylated S/T-rich C-terminal IDRs,False,no_term_above_threshold +8080,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +8081,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +8082,36104,17.812937,0.8959961,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8959961,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,20.0,0.0,1.0,C-terminal helical scaffolds,True,assigned_too_few_test_positives +8083,49116,18.208536,0.8183594,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8183594,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8718472468916519,0.04144184706621755,0.002215330084182543,,18.706849765690603,0.0,18.0,0.0,1.0,C-terminal helix recognition,True,assigned_and_evaluated +8084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-sequence interfacial docking segment,False,no_term_above_threshold +8085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OB-fold AEWGEG turn,False,no_term_above_threshold +8086,48880,18.666622,0.98095703,"Pyridoxal phosphate-dependent transferase, major domain",interpro,69093,"ANL, N-terminal domain",0.953125,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,Motif II PLP helix,True,assigned_too_few_test_positives +8087,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal ligand-recognition module,False,no_term_above_threshold +8088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic membrane-binding helices,False,no_term_above_threshold +8089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface β-strand-loop module,False,no_term_above_threshold +8090,69819,24.672993,0.81103516,"ATPase, nucleotide binding domain",interpro,69819,"ATPase, nucleotide binding domain",0.81103516,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,11.0,17.0,271.6781275890638,3.496088327236268e-25,Cytosolic hydrophobic interaction patches,True,assigned_too_few_test_positives +8091,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-strand interaction domain,False,no_term_above_threshold +8092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged cap-flanked amphipathic helices,False,no_term_above_threshold +8093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse activation with motif peaks,False,no_term_above_threshold +8094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FlgH internal activation patch,False,no_term_above_threshold +8095,64026,15.559649,0.83496094,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.7626953,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9059677180512364,0.015513703848790455,0.002658396101019052,,5.835738264453342,1.0,18.0,9.40988005050505,0.16350361534768657,Cytosolic juxtamembrane regulatory segments,True,assigned_and_evaluated +8096,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-cytosolic TM-flanking low-complexity segments,False,no_term_above_threshold +8097,84152,23.421194,0.9394531,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9394531,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,Noncatalytic C-terminal alpha helices,True,assigned_too_few_test_positives +8098,45324,16.275923,0.9951172,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.93115234,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9979573712255773,0.3884415584415584,0.002215330084182543,,175.34251948051948,14.0,14.0,546.9816513761467,1.3972108468745643e-38,Extracellular beta-strand loop turns,True,assigned_and_evaluated +8099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix context detector,False,no_term_above_threshold +8100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gram-negative outer membrane beta barrel,False,no_term_above_threshold +8101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase coupling elements,False,no_term_above_threshold +8102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal polybasic disordered tails,False,no_term_above_threshold +8103,36914,18.716578,0.98095703,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9375,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,19.0,658.5815464587395,1.5489397236913889e-46,Glycosyltransferase subdomain B loop,True,assigned_too_few_test_positives +8104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter extramembrane beta-domain activation,False,no_term_above_threshold +8105,87489,34.656273,0.93896484,GPI-anchor,keyword,87489,GPI-anchor,0.93896484,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8523174603174604,0.27725975840729944,0.0031014621178555605,0.42857142857142855,89.39646781789641,0.0,19.0,0.0,1.0,C-terminal cell-wall sorting tail,True,assigned_and_evaluated +8106,63831,17.322964,0.90625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.90625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7945727824670517,0.00706467159921631,0.002658396101019052,,2.6574939665718684,0.0,18.0,0.0,1.0,Sparse alpha-helix residue signal,True,assigned_and_evaluated +8107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD C-terminal helix,False,no_term_above_threshold +8108,45804,23.525229,0.9189453,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.88623047,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,2.0,17.0,32.473311546840954,0.0029861593895058876,Transporter transmembrane helices,True,assigned_too_few_test_positives +8109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory extensions,False,no_term_above_threshold +8110,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site entry caps,False,no_term_above_threshold +8111,59224,45.39305,0.9604492,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9604492,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Hydrolase active-site cap loop,True,assigned_and_evaluated +8112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SMC-family hinge/dimerization module,False,no_term_above_threshold +8113,49116,20.299662,0.8378906,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8378906,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9936056838365898,0.18705882352941178,0.002215330084182543,,84.43835294117648,4.0,19.0,18.32378025355359,0.00010708929013330043,Charge-rich extended alpha-helical scaffolds,True,assigned_and_evaluated +8114,4066,19.467686,0.9716797,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9716797,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.8847690941385435,0.16198400734501187,0.002215330084182543,,73.11958091553836,6.0,19.0,226.83956880152186,3.621079991390532e-13,Nuclease active-site microdomain,True,assigned_and_evaluated +8115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GNAT beta-strand core hydrophobics,False,no_term_above_threshold +8116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flanking disorder and cap peaks,False,no_term_above_threshold +8117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop hairpins,False,no_term_above_threshold +8118,36449,19.253748,0.9135742,EamA domain,interpro,64026,MFS transporter superfamily,0.79003906,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,16.0,0.0,1.0,Pre-TM1 start-transfer helix,True,assigned_too_few_test_positives +8119,64026,15.703369,0.79052734,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.6748047,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.8569524655708574,0.01727453431755127,0.002658396101019052,,6.498103992452203,0.0,18.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_and_evaluated +8120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble globular catalytic cores,False,no_term_above_threshold +8121,83419,19.851812,0.97265625,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9560547,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,11.0,15.0,266.59796747967476,2.0140472832231299e-25,Extracellular Ca2+-dependent lectins/enzymes,True,assigned_too_few_test_positives +8122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil junction caps,False,no_term_above_threshold +8123,88058,82.19034,0.91259766,Signal,keyword,88058,Signal,0.91259766,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8949281193639853,0.5636428073928932,0.09127159946832078,0.7233009708737864,6.175445710125048,19.0,20.0,6.844706948640483,2.038363878104551e-15,Signal peptide hydrophobic core,True,assigned_and_evaluated +8124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-backbone binding surfaces,False,no_term_above_threshold +8125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane alpha-helix signature,False,no_term_above_threshold +8126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HMG-box and H1 DNA-binding domains,False,no_term_above_threshold +8127,46078,15.976838,0.90283203,Armadillo-like helical,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8227539,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,11.0,16.0,89.8891173245614,5.087497886156482e-20,HEAT/ARM/TPR alpha-solenoids,True,assigned_too_few_test_positives +8128,50806,18.969519,0.99609375,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.96972656,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,HTH recognition helix detector,True,assigned_too_few_test_positives +8129,52236,22.163715,0.96533203,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.85546875,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,11.0,18.0,136.46088223054517,9.946520512367457e-22,Domain-specific contiguous activation,True,assigned_too_few_test_positives +8130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DDE transposase core DNA-interaction segment,False,no_term_above_threshold +8131,85656,15.68966,0.8847656,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7446289,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.830857142857143,0.0369987143380226,0.0031014621178555605,,11.929442608702429,0.0,11.0,0.0,1.0,Helix N-cap boundary motif,True,assigned_and_evaluated +8132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helix packing interfaces,False,no_term_above_threshold +8133,38654,21.80921,0.9916992,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9785156,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,Conserved internal enzyme motif,True,assigned_too_few_test_positives +8134,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protein low-complexity regions,False,no_term_above_threshold +8135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal beta-sandwich head domains,False,no_term_above_threshold +8136,38873,18.858755,0.88916016,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.83447266,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8900532859680285,0.1801063656801362,0.002215330084182543,,81.30001346801347,3.0,20.0,25.698706896551723,0.00037677026635407905,Post-Walker A lid helix,True,assigned_and_evaluated +8137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemoreceptor periplasmic pre-TM2 helix,False,no_term_above_threshold +8138,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MacB periplasmic WxPY motif,False,no_term_above_threshold +8139,88263,18.113724,0.73583984,Zinc-finger,keyword,88263,Zinc-finger,0.73583984,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8860229997819927,0.08062593658115877,0.014621178555604785,,5.5143254201113745,1.0,17.0,1.5328311394487864,0.7551009893139149,Structured cores of genome regulators,True,assigned_and_evaluated +8140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GATase-2 catalytic core,False,no_term_above_threshold +8141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic α-helical blocks,False,no_term_above_threshold +8142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Heptad-repeat coiled-coil stalks,False,no_term_above_threshold +8143,45317,15.876834,0.94628906,"Six-bladed beta-propeller, TolB-like",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.90771484,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,8.0,16.0,382.1858974358974,1.9346524532341778e-19,Asp-box/WD β-propeller repeats,True,assigned_too_few_test_positives +8144,64148,28.093288,0.78466797,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.74121094,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9117868397535394,0.5536083726793151,0.008418254319893664,0.5263157894736842,65.76284721774812,12.0,16.0,66.73992537313433,1.6956091446209965e-20,Low-complexity charged regulatory IDRs,True,assigned_and_evaluated +8145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FabD-like AT/MAT signature,False,no_term_above_threshold +8146,46277,15.823474,0.8886719,"Nucleic acid-binding, OB-fold",interpro,87697,Knottin,0.85302734,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9555168784910548,0.06660281710391014,0.004873726185201595,,13.665687109411381,1.0,18.0,10.448825797406238,0.1483822125694642,Secondary structure edge patches,True,assigned_and_evaluated +8147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Radical SAM acidic-Pro loop motif,False,no_term_above_threshold +8148,85672,21.650738,0.61376953,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.609375,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6072840062034119,0.16111362217919595,0.01595037660611431,0.2222222222222222,10.100929034956813,15.0,20.0,30.010570469798658,3.116533736045915e-20,Walker A/P-loop context detector,True,assigned_and_evaluated +8149,82029,20.438177,0.93115234,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69433594,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,17.0,11.063462609018371,0.14078347170214411,N-terminal pre-TM polar tail,True,assigned_too_few_test_positives +8150,59229,28.264439,0.9746094,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9746094,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9458370635631155,0.6566656306446186,0.0101905183872397,0.7391304347826086,64.43888384195235,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Rossmann SAM-anchoring acidic motif,True,assigned_and_evaluated +8151,36977,20.026459,0.9301758,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,38317,Pentatricopeptide repeat,0.8066406,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,11.0,11.0,310.5260416666667,9.733668399303052e-28,Eukaryotic protein kinase core,True,assigned_too_few_test_positives +8152,81858,17.10022,0.93066406,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.73339844,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix hydrophobic cores,True,assigned_too_few_test_positives +8153,85672,17.228905,0.73535156,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.851224423432888,0.08509555246824771,0.01595037660611431,,5.335018386689864,2.0,18.0,4.446010439970172,0.1196530925430369,Hydrophobic β-strand segments,True,assigned_and_evaluated +8154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OmpR/PhoB and TPR sensor activation,False,no_term_above_threshold +8155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/P/T-rich regulatory IDRs,False,no_term_above_threshold +8156,69819,25.66755,0.8696289,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8359375,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,N-terminal phosphate-binding loops,True,assigned_too_few_test_positives +8157,64507,35.729504,0.9946289,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9946289,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997034400948991,0.9328843995510663,0.003987594151528578,1.0,233.94667664297296,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat core detector,True,assigned_and_evaluated +8158,87413,35.36289,0.6723633,Disulfide bond,keyword,87413,Disulfide bond,0.6723633,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.628342025398509,0.21391915214377227,0.0717766947275144,0.1728395061728395,2.980342755484531,14.0,15.0,11.038735700588509,2.986193219457333e-14,Mitochondrial IMS helical context signature,True,assigned_and_evaluated +8159,48767,16.423742,0.85009766,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.85009766,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,15.0,0.0,1.0,AlkB/ALKBH 2OG demethylases,True,assigned_too_few_test_positives +8160,85672,26.101112,0.69921875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6977539,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.713029666316474,0.15679688573199202,0.01595037660611431,0.027777777777777776,9.830293641586278,18.0,19.0,37.90808901448251,8.198682763328136e-28,Type VII ESX coupling ATPases,True,assigned_and_evaluated +8161,32555,15.838578,0.81933594,"proton-transporting ATP synthase activity, rotational mechanism",go_mf,87598,Hydrogen ion transport,0.7216797,70,go,GO:0046933,go_mf:go:GO:0046933,23.0,2257.0,0.9695224008407614,0.3864167891388972,0.0101905183872397,0.782608695652174,37.91924752549961,6.0,17.0,126.76328844790929,1.1126483400426275e-11,Extracytoplasmic soluble charged domains,True,assigned_and_evaluated +8162,27735,16.44301,0.72558594,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,24917,nucleus,0.6040039,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.7926249008723235,0.28231164975265144,0.011519716437749225,0.38461538461538464,24.506822826605166,5.0,14.0,16.155701278994147,1.6629909535481364e-05,Plant TF disordered activation domains,True,assigned_and_evaluated +8163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell wall-binding helices,False,no_term_above_threshold +8164,39958,23.539055,0.9370117,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.9370117,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9973345179920036,0.36170634920634925,0.002658396101019052,0.6666666666666666,136.0618716931217,0.0,8.0,0.0,1.0,Two-component coiled-coil helices,True,assigned_and_evaluated +8165,88147,20.214106,0.7866211,Toxin-antitoxin system,keyword,88147,Toxin-antitoxin system,0.7866211,120,keywords,Toxin-antitoxin system,keyword:keywords:Toxin-antitoxin system,10.0,2257.0,0.8962171784601691,0.550886132033673,0.004430660168365086,0.8,124.335,18.0,18.0,236.59126984126982,1.243423145389655e-42,N-terminal basic nucleic-acid interfaces,True,assigned_and_evaluated +8166,82029,18.025694,0.7597656,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.75390625,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,Glycosyltransferase juxtamembrane entry loops,True,assigned_too_few_test_positives +8167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal activation motifs,False,no_term_above_threshold +8168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central structured functional core,False,no_term_above_threshold +8169,87882,15.682601,0.61279297,Palmitate,keyword,87882,Palmitate,0.61279297,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.573078631719236,0.08554866341751587,0.002658396101019052,0.16666666666666666,32.18055555555555,3.0,18.0,11.102607076350091,0.004033718502029921,Secreted/lumenal surface regions,True,assigned_and_evaluated +8170,63831,35.313503,0.9511719,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9511719,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9791203909373611,0.06594751566015934,0.002658396101019052,,24.807257140829936,0.0,16.0,0.0,1.0,PAS/LOV sensory domains,True,assigned_and_evaluated +8171,37640,26.04019,0.9770508,EF-hand domain,interpro,46081,EF-hand domain pair,0.96777344,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,8.0,0.0,1.0,ABC NBD hydrophobic stretch,True,assigned_too_few_test_positives +8172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intradiol dioxygenase pan-chain activation,False,no_term_above_threshold +8173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad interface activation,False,no_term_above_threshold +8174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane alpha helices,False,no_term_above_threshold +8175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positive-inside loops DHp detector,False,no_term_above_threshold +8176,45714,23.96411,0.99609375,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.99609375,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,DHp coiled-coil interface residues,True,assigned_too_few_test_positives +8177,87413,21.165014,0.6245117,Disulfide bond,keyword,87413,Disulfide bond,0.6245117,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5638557411827101,0.08444782001360351,0.0717766947275144,,1.1765353689549576,10.0,18.0,6.570676012255064,8.31673532651112e-07,Surface-exposed capping loops,True,assigned_and_evaluated +8178,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich low-complexity repeats,False,no_term_above_threshold +8179,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M50 periplasmic vestibule loop,False,no_term_above_threshold +8180,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking alpha helix,False,no_term_above_threshold +8181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity terminal IDRs,False,no_term_above_threshold +8182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended charged coiled-coil stalks,False,no_term_above_threshold +8183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M4 mature Ca2+-adjacent segment,False,no_term_above_threshold +8184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphosugar N-terminal helical cap,False,no_term_above_threshold +8185,72011,17.752043,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9355469,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,17.0,19.0,528.1693590411674,6.354281494589475e-45,ANL AMP-binding loop signature,True,assigned_too_few_test_positives +8186,36104,15.639118,0.89160156,Rho GTPase-activating protein domain,interpro,49116,Armadillo-type fold,0.7128906,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Alpha-helical scaffold domains,True,assigned_too_few_test_positives +8187,49116,21.00894,0.9199219,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9199219,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.991651865008881,0.3245088245088245,0.002215330084182543,0.4,146.4832833832834,10.0,20.0,43.518978102189784,1.4475001995303197e-14,HEAT-repeat alpha-solenoids,True,assigned_and_evaluated +8188,88161,23.069838,0.61865234,Transmembrane helix,keyword,88159,Transmembrane,0.6176758,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5130623761860077,0.19110717539115446,0.1847585290208241,,1.0343618581722678,9.0,16.0,3.0529642694583523,0.001397889513799062,Alpha-helical structural signal,True,assigned_and_evaluated +8189,61392,20.699162,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.6635742,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9996190476190476,0.8801587301587303,0.0031014621178555605,1.0,283.78832199546486,14.0,14.0,167.4747191011236,2.3187224721210777e-31,LRR inter-repeat capping turn,True,assigned_and_evaluated +8190,84152,18.002369,0.88671875,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.88671875,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,14.0,0.0,1.0,Glycine-rich aromatic binding loops,True,assigned_too_few_test_positives +8191,29104,23.639303,0.8408203,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.8388672,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,13.0,13.0,428.9280575539568,1.6667954153733173e-34,Catalytic TM helix environment,True,assigned_too_few_test_positives +8192,36091,17.206894,0.99853516,GNAT domain,interpro,85712,3.40.630.30,0.9970703,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,16.0,17.0,355.1511541325391,3.960299025280445e-40,Conserved GNAT beta-strand motif,True,assigned_too_few_test_positives +8193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline/serine-rich regulatory IDRs,False,no_term_above_threshold +8194,37446,16.0065,0.7114258,F-box domain,interpro,37446,F-box domain,0.7114258,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.610095238095238,0.006203592055637792,0.0031014621178555605,,2.000215324224928,0.0,16.0,0.0,1.0,Exposed beta-hairpin loops,True,assigned_and_evaluated +8195,49061,22.247902,0.92089844,WD40/YVTN repeat-like-containing domain superfamily,interpro,87413,Disulfide bond,0.6694336,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9539191181183105,0.11450014400436004,0.012405848471422242,,9.229529464922878,0.0,15.0,0.0,1.0,Extracellular beta-solenoid repeats,True,assigned_and_evaluated +8196,85682,24.092396,0.7607422,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7607422,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8852598566308243,0.1752062212182029,0.011076650420912717,,15.817617651579356,14.0,14.0,102.26586620926243,2.160832948637194e-28,Mid-core Rossmann β-strand,True,assigned_and_evaluated +8197,45714,15.828904,0.96533203,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.95410156,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,17.0,0.0,1.0,HisKA DHp H+5 position,True,assigned_too_few_test_positives +8198,47529,18.801394,0.9082031,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9082031,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9271251673360107,0.3998833444810491,0.007089056269384138,0.25,56.408544280857996,19.0,19.0,77.32944228274968,5.9100056368901175e-36,Ig/FnIII beta-sheet interface hotspots,True,assigned_and_evaluated +8199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal DNA-binding activation,False,no_term_above_threshold +8200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane anchors and amphipathic helices,False,no_term_above_threshold +8201,36104,17.862024,0.8413086,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8413086,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Small polyanion and interface binders,True,assigned_too_few_test_positives +8202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-centered charged beta-hairpins,False,no_term_above_threshold +8203,36115,16.01588,0.9868164,BTB/POZ domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6870117,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,16.0,0.0,1.0,Flexible active-site gating loops,True,assigned_too_few_test_positives +8204,29104,16.36905,0.7763672,NADH dehydrogenase (ubiquinone) activity,go_mf,87276,Cell membrane,0.60009766,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,16.0,0.0,1.0,Cytoplasmic interhelical loop linkers,True,assigned_too_few_test_positives +8205,66234,21.96063,0.7973633,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.7973633,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,5.0,17.0,69.58566760037348,1.550170859482114e-08,Protease regulatory propeptides and tails,True,assigned_too_few_test_positives +8206,55053,16.70291,0.79833984,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.79833984,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,16.0,0.0,1.0,Non-catalytic terminal TM anchors,True,assigned_too_few_test_positives +8207,36104,16.995922,0.94921875,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.94921875,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Hydrophobic/aromatic beta-strand segments,True,assigned_too_few_test_positives +8208,87326,31.417116,0.6958008,Coiled coil,keyword,87326,Coiled coil,0.6958008,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7149601973547826,0.34345177664746107,0.03943287549844927,0.30337078651685395,8.709782695430558,18.0,19.0,11.943973912366028,6.647492796621427e-19,Extended coiled-coil tether domains,True,assigned_and_evaluated +8209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter and channel TM cores,False,no_term_above_threshold +8210,38873,16.353495,0.8515625,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7211914,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9957371225577264,0.6803986710963454,0.002215330084182543,0.6,307.13196013289036,13.0,13.0,171.32471264367817,2.6588953672088044e-29,ABC NBD A-loop region,True,assigned_and_evaluated +8211,52270,19.501425,0.86035156,"WD40 repeat, conserved site",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7739258,43,ip,IPR019775,interpro:ip:IPR019775,,,,,,,,0.0,16.0,0.0,1.0,Proline-anchored loop motif,True,assigned_too_few_test_positives +8212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein cytosolic regulatory domains,False,no_term_above_threshold +8213,81349,17.08925,0.8613281,1.10.287.1490,gene3d,81349,1.10.287.1490,0.8613281,31,gene3d,1.10.287.1490,gene3d:gene3d:1.10.287.1490,,,,,,,,0.0,18.0,0.0,1.0,Polar-face coiled-coil heptads,True,assigned_too_few_test_positives +8214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal structural cap segments,False,no_term_above_threshold +8215,48883,21.79728,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,19.0,19.0,480.8145161290322,2.994783325734321e-50,PLP phosphate-binding cup loop,True,assigned_too_few_test_positives +8216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical nucleic acid recognition modules,False,no_term_above_threshold +8217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic terminal low-complexity IDRs,False,no_term_above_threshold +8218,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM signal anchors and coiled-coils,False,no_term_above_threshold +8219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PRPP-binding Type I PRTase module,False,no_term_above_threshold +8220,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane TM boundary loops,False,no_term_above_threshold +8221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHS/HSS flanking helical motifs,False,no_term_above_threshold +8222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature N-terminal extracellular loops,False,no_term_above_threshold +8223,64146,18.04329,0.67822266,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.67822266,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.5943129373232099,0.04195237169401934,0.007975188303057155,,5.260361272966758,4.0,19.0,14.071512862874675,0.00029231999703100385,Interdomain coupling helix activation,True,assigned_and_evaluated +8224,47529,16.553467,0.86328125,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.86328125,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.895805443998215,0.041614878155484265,0.007089056269384138,,5.870298749808,2.0,19.0,8.13994129292102,0.04133969154815049,Beta-sheet edge hydrophobes,True,assigned_and_evaluated +8225,37894,23.073132,0.91748047,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7885742,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,12.0,0.0,1.0,Rossmann-like oxidoreductase lid helix,True,assigned_too_few_test_positives +8226,52236,19.010172,0.9794922,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.97265625,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,18.0,173.67748647523928,1.0369554419320324e-29,Alpha-solenoid turn/linker sites,True,assigned_too_few_test_positives +8227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal α/β cofactor-binding domain,False,no_term_above_threshold +8228,81739,20.573391,0.9194336,"DNA helicase RuvA subunit, C-terminal domain",gene3d,81739,"DNA helicase RuvA subunit, C-terminal domain",0.9194336,27,gene3d,1.10.8.10,gene3d:gene3d:1.10.8.10,6.0,2257.0,0.9123722789871169,0.2466551872289577,0.002658396101019052,,92.78345959595958,0.0,13.0,0.0,1.0,Ferritin-like di-metal helical bundle,True,assigned_and_evaluated +8229,36914,16.130733,0.99902344,Glycosyltransferase 2-like,interpro,85388,Glutaredoxin,0.8261719,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +8230,87970,16.16076,0.7006836,Protein phosphatase,keyword,87970,Protein phosphatase,0.7006836,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,18.0,0.0,1.0,C-terminal β-α interaction cap,True,assigned_too_few_test_positives +8231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix-exit motif,False,no_term_above_threshold +8232,64599,19.616251,0.97998047,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.97998047,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,12.0,12.0,662.4555555555555,3.162576276653441e-34,J-protein accessory regions,True,assigned_too_few_test_positives +8233,63960,27.300007,0.90527344,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.90527344,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,17.0,17.0,193.57467532467533,6.347107800690125e-39,FAD-binding helix–loop–beta motif,True,assigned_too_few_test_positives +8234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity scaffold IDRs,False,no_term_above_threshold +8235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electrostatic nucleic acid-binding modules,False,no_term_above_threshold +8236,64016,17.143986,0.6386719,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.63427734,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7085714285714285,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,0.0,17.0,0.0,1.0,Periplasmic cytochrome c/thioredoxin modules,True,assigned_and_evaluated +8237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structured domain peaks,False,no_term_above_threshold +8238,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase ATP-lid motif,False,no_term_above_threshold +8239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-adjacent small alpha helices,False,no_term_above_threshold +8240,39971,23.935257,0.9013672,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.86572266,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,Hydrolase catalytic core loop,True,assigned_too_few_test_positives +8241,87326,25.456684,0.69189453,Coiled coil,keyword,87326,Coiled coil,0.69189453,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6968235623367469,0.2214242625832641,0.03943287549844927,0.14606741573033707,5.615219782589068,9.0,19.0,5.971986956183014,1.026054543559621e-05,Coiled-coil dimerization scaffolds,True,assigned_and_evaluated +8242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-start capping motif,False,no_term_above_threshold +8243,36668,21.214643,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9863281,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,17.0,17.0,532.3303571428571,3.538165212749175e-46,ANL AMP-binding A-domain core,True,assigned_too_few_test_positives +8244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil scaffolds,False,no_term_above_threshold +8245,85672,19.114765,0.7001953,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.69140625,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7460603331832508,0.06402284719159768,0.01595037660611431,,4.013876836428777,2.0,19.0,4.212009890498057,0.13129493792045877,Charged loops at functional sites,True,assigned_and_evaluated +8246,49045,17.720188,0.99902344,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.87841797,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,14.0,0.0,1.0,Hydrophobic beta-strand core scaffolds,True,assigned_too_few_test_positives +8247,4066,26.843943,0.94140625,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.94140625,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.9958259325044405,0.5219550342130987,0.002215330084182543,0.6,235.6105024437928,12.0,17.0,507.05315379163716,5.653242369037591e-31,Endonuclease domains and interfaces,True,assigned_and_evaluated +8248,72011,16.22365,0.98291016,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.90771484,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,13.0,13.0,590.3069306930694,2.4178087537758372e-36,ANL adenylation lid loop,True,assigned_too_few_test_positives +8249,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Upstream catalytic support subdomain,False,no_term_above_threshold +8250,37894,25.278973,0.88427734,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.88427734,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,14.0,405.5850340136054,8.480210049747195e-20,Ligand-access gating loops,True,assigned_too_few_test_positives +8251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor-effector helical linkers,False,no_term_above_threshold +8252,47529,21.250381,0.90625,Immunoglobulin-like fold,interpro,87697,Knottin,0.85253906,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9655845604640786,0.18060479301326213,0.007089056269384138,0.0625,25.47656361443329,16.0,19.0,65.11953034336815,1.6340624439516e-27,Ig/FN3 beta-hairpin turn residues,True,assigned_and_evaluated +8253,36535,18.892523,0.8251953,Protein kinase domain,interpro,36535,Protein kinase domain,0.8251953,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.868580329327993,0.04553454465265455,0.004430660168365086,,10.277146728104134,0.0,16.0,0.0,1.0,Disordered loops and maturation junctions,True,assigned_and_evaluated +8254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CNA-B GDYVW motif,False,no_term_above_threshold +8255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged dynamic coupling linkers,False,no_term_above_threshold +8256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-grip hydrophobic cavities,False,no_term_above_threshold +8257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TF IDRs and periplasmic loops,False,no_term_above_threshold +8258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved short beta-strand motif,False,no_term_above_threshold +8259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site α/β loop scaffolds,False,no_term_above_threshold +8260,87276,45.43184,0.71728516,Cell membrane,keyword,88161,Transmembrane helix,0.68603516,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8065385516756504,0.5443088077372429,0.11120957022596367,0.6573705179282868,4.8944421476611835,7.0,19.0,3.023070682486563,0.009073934506924218,Membrane-helix boundary segments,True,assigned_and_evaluated +8261,64620,19.575594,0.9667969,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.9667969,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,19.0,306.97311212814645,8.535264209916709e-44,GHKL ATP-lid disordered tails,True,assigned_too_few_test_positives +8262,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coil-to-beta cap motif,False,no_term_above_threshold +8263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electropositive nucleic acid-binding surfaces,False,no_term_above_threshold +8264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transcriptional cofactor-binding IDRs,False,no_term_above_threshold +8265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane transport helix bundle,False,no_term_above_threshold +8266,36104,19.478468,0.96533203,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.96533203,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Active-site rim segments,True,assigned_too_few_test_positives +8267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thrombospondin type-1 repeats,False,no_term_above_threshold +8268,88058,32.2589,0.68896484,Signal,keyword,88058,Signal,0.68896484,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6905665244990604,0.13047100180793963,0.09127159946832078,,1.42948083048796,3.0,20.0,1.0807432024169183,0.8334769282943363,Short disordered low-complexity segments,True,assigned_and_evaluated +8269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved histidine-centered alpha/beta motif,False,no_term_above_threshold +8270,37446,19.984482,0.9741211,F-box domain,interpro,63831,F-box-like domain superfamily,0.97314453,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9549841269841268,0.03709520870613277,0.0031014621178555605,,11.960555149963094,0.0,15.0,0.0,1.0,Solvent-exposed helical interfaces,True,assigned_and_evaluated +8271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core region,False,no_term_above_threshold +8272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity periplasmic linkers,False,no_term_above_threshold +8273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipidation and maturation motifs,False,no_term_above_threshold +8274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal/cofactor uptake SBPs,False,no_term_above_threshold +8275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal transmembrane alpha-helices,False,no_term_above_threshold +8276,46284,18.733465,0.98779297,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.98779297,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,16.0,16.0,1192.42,3.4794486095487155e-49,Charged helical active-site motifs,True,assigned_too_few_test_positives +8277,36104,20.278131,0.94677734,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.94677734,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Basic amphipathic helical patches,True,assigned_too_few_test_positives +8278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase helical accessory subdomain,False,no_term_above_threshold +8279,88139,15.578733,0.65625,Thylakoid,keyword,88139,Thylakoid,0.65625,193,keywords,Thylakoid,keyword:keywords:Thylakoid,30.0,2257.0,0.8925535099535997,0.4562363356025519,0.01329198050509526,0.7333333333333333,34.32418031516532,3.0,12.0,30.79597107438017,0.00020162179017550063,Small membrane interhelical loops,True,assigned_and_evaluated +8280,81858,20.297691,0.8979492,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.64501953,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,16.0,0.0,1.0,N-terminal signal-anchor helix,True,assigned_too_few_test_positives +8281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich low-complexity IDRs,False,no_term_above_threshold +8282,37291,17.033888,0.99853516,DnaJ domain,interpro,64599,Chaperone J-domain superfamily,0.99853516,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,14.0,14.0,701.4235294117647,3.992115037302932e-40,J-domain amphipathic helix pair,True,assigned_too_few_test_positives +8283,43538,15.639807,0.9140625,Rho GTPase activation protein,interpro,43538,Rho GTPase activation protein,0.9140625,34,ip,IPR008936,interpro:ip:IPR008936,,,,,,,,0.0,20.0,0.0,1.0,Amphipathic helical oligomerization scaffolds,True,assigned_too_few_test_positives +8284,59211,27.563532,0.9692383,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9692383,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,1.0,1.0,0.011076650420912717,1.0,90.28,18.0,18.0,244.34836065573774,7.288942336525665e-43,Glycosyltransferase metal-binding loops,True,assigned_and_evaluated +8285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HSF DBD basic activation motif,False,no_term_above_threshold +8286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane inserting hydrophobic helices,False,no_term_above_threshold +8287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BPI-fold lipid-contact activation,False,no_term_above_threshold +8288,88154,32.970367,0.8017578,Transit peptide,keyword,88154,Transit peptide,0.8017578,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.861397223466189,0.23822898550910646,0.010633584404076208,0.08333333333333333,22.403450845585553,17.0,18.0,27.5752802263576,5.890906220761299e-24,Mature thylakoid protein activation,True,assigned_and_evaluated +8289,50338,19.42556,0.7890625,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.7890625,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane gating helices and caps,True,assigned_too_few_test_positives +8290,24974,16.258217,0.7504883,nucleolus,go_cc,24974,nucleolus,0.7504883,141,go,GO:0005730,go_cc:go:GO:0005730,12.0,2257.0,0.6091128433556051,0.17065426081819524,0.005316792202038104,0.25,32.09722222222222,18.0,18.0,40.864290610006854,3.2435483698548354e-29,Nucleolar RG-rich disordered tails,True,assigned_and_evaluated +8291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil scaffolds,False,no_term_above_threshold +8292,82029,33.26564,0.9902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.97802734,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,C-terminal MFS TM hairpin,True,assigned_too_few_test_positives +8293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity IDRs,False,no_term_above_threshold +8294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal lipid-binding domains,False,no_term_above_threshold +8295,45272,29.768919,1.0,"Lambda repressor-like, DNA-binding domain superfamily",interpro,37071,Homeodomain,0.9033203,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,15.0,17.0,392.5877963125548,7.619333316654671e-38,HTH/homeodomain recognition helix,True,assigned_too_few_test_positives +8296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RTK/phage disulfide beta-strand motif,False,no_term_above_threshold +8297,36104,25.739918,0.99853516,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99853516,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Amphipathic helical stalks and hinges,True,assigned_too_few_test_positives +8298,48883,16.884375,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,PLP Lys-flanking active-site loop,True,assigned_too_few_test_positives +8299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix exits,False,no_term_above_threshold +8300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arg rich structured site hotspots,False,no_term_above_threshold +8301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/HAMP sensory modules,False,no_term_above_threshold +8302,64594,22.920502,0.96728516,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9667969,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9320531347265452,0.4832826222938928,0.003544528134692069,0.75,136.34610981466452,20.0,20.0,236.59126984126982,5.270626982754627e-47,Acidic Q/N-rich C-terminal TADs,True,assigned_and_evaluated +8303,36272,15.794719,0.9350586,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,85664,Glycogen Phosphorylase B;,0.83691406,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,17.0,0.0,1.0,Glycosyltransferase acceptor-binding loop,True,assigned_too_few_test_positives +8304,87198,16.092207,0.7470703,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.7470703,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,4.0,17.0,171.07890961262552,1.5708167897748106e-08,T3SS/flagellar secretion proteins,True,assigned_too_few_test_positives +8305,88161,19.140623,0.6020508,Transmembrane helix,keyword,88161,Transmembrane helix,0.6020508,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.685187936607236,0.30853837794568334,0.1847585290208241,0.016786570743405275,1.6699547218786746,6.0,19.0,1.7139448530292505,0.19457521387369395,Basic amphipathic helices,True,assigned_and_evaluated +8306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early-domain nucleotide-adjacent helix-loop,False,no_term_above_threshold +8307,88058,40.86151,0.67333984,Signal,keyword,88161,Transmembrane helix,0.65283203,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7424675625908271,0.24627361240844028,0.09127159946832078,0.024271844660194174,2.6982502097371346,1.0,17.0,0.42382086369290917,1.0,Extracytoplasmic juxtamembrane stem,True,assigned_and_evaluated +8308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site gating segments,False,no_term_above_threshold +8309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short aromatic transition-edge patches,False,no_term_above_threshold +8310,88164,19.882963,0.71777344,Transposition,keyword,88164,Transposition,0.71777344,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.6984014209591474,0.13132919805050952,0.002215330084182543,,59.282000000000004,0.0,16.0,0.0,1.0,Nop-domain family detector,True,assigned_and_evaluated +8311,69093,26.892515,0.9970703,"ANL, N-terminal domain",interpro,69093,"ANL, N-terminal domain",0.9970703,40,ip,IPR042099,interpro:ip:IPR042099,,,,,,,,11.0,17.0,338.40608875129,2.954055391910566e-26,Nucleotide 5′-phosphate–binding α/β core,True,assigned_too_few_test_positives +8312,39958,19.408264,0.8417969,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8417969,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9998519176662223,0.9484126984126984,0.002658396101019052,1.0,356.76124338624334,5.0,20.0,118.29563492063491,1.2179954721564423e-09,Basic-biased contiguous alpha helices,True,assigned_and_evaluated +8313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro/Thr-rich disordered low-complexity regions,False,no_term_above_threshold +8314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged nuclease cleft flanks,False,no_term_above_threshold +8315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,c-di-GMP EAL domain,False,no_term_above_threshold +8316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ACAD/ACOX C-terminal helical interface,False,no_term_above_threshold +8317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-pass transmembrane helix detector,False,no_term_above_threshold +8318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DsbD periplasmic HxDExFG CXXC,False,no_term_above_threshold +8319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic recognition helices,False,no_term_above_threshold +8320,82608,25.446846,0.9980469,Ankyrin repeat-containing domain,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.9975586,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.9999444197421076,0.9861111111111112,0.003544528134692069,1.0,278.20659722222223,17.0,17.0,170.34571428571428,5.351432831165409e-38,Ankyrin-repeat hydrophobic spine,True,assigned_and_evaluated +8321,45551,20.22868,0.97753906,SKP1/BTB/POZ domain superfamily,interpro,63831,F-box-like domain superfamily,0.8720703,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,17.0,0.0,1.0,Cullin-RING adaptor recruitment helices,True,assigned_too_few_test_positives +8322,63892,20.022713,0.96728516,Fibronectin type III superfamily,interpro,47529,Immunoglobulin-like fold,0.74365234,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,11.0,17.0,187.27327241576242,2.2283550569760233e-23,CLCA ectodomain juxtamembrane motif,True,assigned_too_few_test_positives +8323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic membrane and assembly helices,False,no_term_above_threshold +8324,52236,25.107437,0.94140625,Tetratricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.9267578,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,18.0,173.67748647523928,1.0369554419320324e-29,C-terminal docking/anchoring tail,True,assigned_too_few_test_positives +8325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter periplasmic loop,False,no_term_above_threshold +8326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic active-site cores,False,no_term_above_threshold +8327,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β–α active-site loop,False,no_term_above_threshold +8328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoprotein surface beta-strand patches,False,no_term_above_threshold +8329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ig V-domain CDR3 peak,False,no_term_above_threshold +8330,42974,16.37172,0.94140625,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.88720703,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9990476190476191,0.6091836734693877,0.0031014621178555605,1.0,196.41822157434402,7.0,14.0,66.54129464285714,9.195188689057784e-12,Conserved functional cores and residues,True,assigned_and_evaluated +8331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal glycosylation catalytic loops,False,no_term_above_threshold +8332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic aromatic C-terminal cap,False,no_term_above_threshold +8333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane polybasic interface anchor,False,no_term_above_threshold +8334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ProRS insertion-domain regional activation,False,no_term_above_threshold +8335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Buried hydrophobic core packing,False,no_term_above_threshold +8336,58239,18.958622,0.7285156,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7285156,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7537156066756879,0.13651297809349824,0.017722640673460344,0.125,7.702744788925639,20.0,20.0,35.851473241130485,2.9591156525725853e-31,Small amphipathic regulatory helices,True,assigned_and_evaluated +8337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain edge helix cap motifs,False,no_term_above_threshold +8338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity intrinsically disordered regions,False,no_term_above_threshold +8339,85682,19.615454,0.7319336,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7319336,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7451881720430108,0.05044131716266176,0.011076650420912717,,4.5538421134451035,15.0,17.0,90.23458783170214,2.7484456081855346e-28,Oxidoreductase active-site catalytic helix,True,assigned_and_evaluated +8340,48241,19.328598,0.94091797,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.94091797,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,0.0,19.0,0.0,1.0,Asparagine strand-capping motif,True,assigned_too_few_test_positives +8341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad extracellular and disordered activation,False,no_term_above_threshold +8342,52941,18.259575,0.77685547,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.7026367,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,17.0,260.353711790393,4.679078553617228e-41,Transmembrane helix-loop hairpins,True,assigned_too_few_test_positives +8343,47531,16.262203,0.7558594,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.7558594,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,11.0,15.0,185.2629943502825,1.1536866250132997e-23,Active-site loop-helix N-caps,True,assigned_too_few_test_positives +8344,37894,20.368391,0.95996094,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8120117,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR Rossmann cofactor-binding motif,True,assigned_too_few_test_positives +8345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory/membrane peripheral IDRs,False,no_term_above_threshold +8346,63951,23.144081,0.9848633,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.87646484,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9985172004744958,0.5645884979218312,0.003987594151528578,1.0,141.58624886773035,18.0,18.0,161.13783783783785,1.0016010608753668e-39,Extracellular Ig-like beta-sandwiches,True,assigned_and_evaluated +8347,85364,26.54054,0.9711914,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9711914,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,PBP/VFT loop-beta cleft junctions,True,assigned_too_few_test_positives +8348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coils and low-complexity tails,False,no_term_above_threshold +8349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-adjacent helical scaffolds,False,no_term_above_threshold +8350,64016,28.17042,0.9921875,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.9921875,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9989206349206349,0.6758503401360543,0.0031014621178555605,1.0,217.91345966958207,19.0,19.0,221.63940520446096,2.5665458548251803e-44,Proline-centered loop-to-beta cap,True,assigned_and_evaluated +8351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical catalytic regulatory hotspots,False,no_term_above_threshold +8352,37020,17.850426,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9711914,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,19.0,730.7548666186012,2.5754498304135963e-47,Glycosyltransferase donor-site helix,True,assigned_too_few_test_positives +8353,39971,16.52256,0.7919922,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.765625,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,Metal-dependent phosphohydrolase active site,True,assigned_too_few_test_positives +8354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase/AAA+ motor signature,False,no_term_above_threshold +8355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed helical patches,False,no_term_above_threshold +8356,64026,25.588531,0.8671875,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.8671875,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9093365911446766,0.4814775487754571,0.002658396101019052,0.5,181.1158045977011,13.0,13.0,169.3778409090909,3.0832708315255183e-29,Six-helix transmembrane core,True,assigned_and_evaluated +8357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helix hydrophobes,False,no_term_above_threshold +8358,58239,20.540216,0.7529297,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7529297,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8455683355886333,0.23758016639510596,0.017722640673460344,0.1,13.405460888843855,9.0,17.0,18.98019171589261,4.145128204952723e-10,KGN[F/I/V]LE[V/A/I]N helical motif,True,assigned_and_evaluated +8359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal extensions,False,no_term_above_threshold +8360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CRN effector C-terminal IDR,False,no_term_above_threshold +8361,36914,20.034657,0.88134766,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.88134766,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,10.0,17.0,432.9774872912128,6.980868627290594e-25,Processive GT2 catalytic helix-loop,True,assigned_too_few_test_positives +8362,48767,22.953716,1.0,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,1.0,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,17.0,17.0,931.5781249999999,3.5958711901585488e-50,TF-B3 DNA-binding domain,True,assigned_too_few_test_positives +8363,58239,26.33941,0.63623047,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63623047,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6927717636445647,0.2669261506953539,0.017722640673460344,0.4,15.061308052985346,7.0,7.0,35.851473241130485,2.785374159851466e-11,Ras-like GTPase catalytic core,True,assigned_and_evaluated +8364,36914,20.28097,0.99560547,Glycosyltransferase 2-like,interpro,64016,Thioredoxin-like superfamily,0.8203125,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,10.0,0.0,1.0,Conserved ABC NBD beta-strand,True,assigned_too_few_test_positives +8365,64058,22.559977,0.75634766,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.75634766,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7402553977453665,0.30593251137747624,0.006202924235711121,0.2857142857142857,49.320691298497415,18.0,19.0,107.99818858810505,7.309242727382826e-36,Oxidoreductase C-terminal interface module,True,assigned_and_evaluated +8366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA glycosylase catalytic cores,False,no_term_above_threshold +8367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tails,False,no_term_above_threshold +8368,25169,18.969992,0.7573242,pilus,go_cc,25169,pilus,0.7573242,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.883214920071048,0.047354956634656734,0.002215330084182543,,21.37602742488405,0.0,15.0,0.0,1.0,Terminal beta-rich ligand-binding heads,True,assigned_and_evaluated +8369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-gating helical lids,False,no_term_above_threshold +8370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTF2-like domain activation,False,no_term_above_threshold +8371,50338,16.635317,0.8383789,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8383789,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,S-helix/HAMP coiled-coil linkers,True,assigned_too_few_test_positives +8372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C/PPM catalytic beta-core,False,no_term_above_threshold +8373,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen triple-helix glycine periodicity,False,no_term_above_threshold +8374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-acidic glycan-binding loops,False,no_term_above_threshold +8375,55053,16.913795,0.96777344,Chloramphenicol acetyltransferase-like domain superfamily,interpro,45289,Dimeric alpha-beta barrel,0.79785156,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,17.0,0.0,1.0,PAC beta-strand hydrophobic/aromatic residues,True,assigned_too_few_test_positives +8376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad activation in nucleic-acid-associated proteins,False,no_term_above_threshold +8377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEBP central PGxTxxFGxE motif,False,no_term_above_threshold +8378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-pass transmembrane anchors,False,no_term_above_threshold +8379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central-biased disordered trafficking scaffolds,False,no_term_above_threshold +8380,36104,18.245697,0.984375,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.984375,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,DUB S1 UBL-binding surface,True,assigned_too_few_test_positives +8381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic and ion-translocation cores,False,no_term_above_threshold +8382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal amphipathic helical hairpin,False,no_term_above_threshold +8383,72011,17.057753,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9482422,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,11.0,11.0,590.3069306930694,7.405995892647381e-31,ANL AMP-binding adenylation core,True,assigned_too_few_test_positives +8384,37020,17.659678,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,15.0,16.0,765.6806506849315,9.224784285149201e-43,Tyrosine-centered donor-binding helix,True,assigned_too_few_test_positives +8385,36914,27.700748,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8666992,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,12.0,15.0,588.8493827160494,3.2777973775872965e-32,Glycosyltransferase acceptor-binding surface,True,assigned_too_few_test_positives +8386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic low-complexity linkers,False,no_term_above_threshold +8387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix boundary recognition,False,no_term_above_threshold +8388,37020,16.50297,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,18.0,725.9786910197869,1.266441663928211e-44,Aromatic glycosyltransferase active site loop,True,assigned_too_few_test_positives +8389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted extracellular low-complexity repeats,False,no_term_above_threshold +8390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-tunable S/P-rich linker IDRs,False,no_term_above_threshold +8391,87970,17.615482,0.7363281,Protein phosphatase,keyword,87970,Protein phosphatase,0.7363281,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,15.0,0.0,1.0,FabD-like MAT/AT recognition,True,assigned_too_few_test_positives +8392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-rich modules,False,no_term_above_threshold +8393,47717,19.28346,0.98291016,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.98291016,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,16.0,18.0,243.10295616717633,5.433401732011252e-37,RecA1-RecA2 connector helix,True,assigned_too_few_test_positives +8394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site lid/flap modules,False,no_term_above_threshold +8395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pore-lining signal anchor,False,no_term_above_threshold +8396,82597,20.907484,0.90771484,Tetratricopeptide repeat domain,gene3d,46079,Tetratricopeptide-like helical domain superfamily,0.9033203,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9357260386672152,0.1003303034927099,0.0057598582188746125,,17.418884229465096,7.0,19.0,35.891554867561055,1.0885041546843333e-09,Amphipathic TPR helix starts,True,assigned_and_evaluated +8397,87586,16.328024,0.6772461,Host membrane,keyword,88161,Transmembrane helix,0.6386719,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7604334063793524,0.10614318094799408,0.01639344262295082,0.02702702702702703,6.474734037827639,1.0,18.0,3.5885999759239193,0.3849937413097085,Transmembrane helix exit interface,True,assigned_and_evaluated +8398,55054,26.781132,0.8432617,HAD superfamily,interpro,55054,HAD superfamily,0.8432617,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.7976021314387212,0.48421946536700633,0.002215330084182543,0.6,218.57666666666668,13.0,17.0,256.1378056840714,8.427090866466218e-30,Sugar-phosphate catalytic core module,True,assigned_and_evaluated +8399,39971,27.25961,1.0,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,9.0,15.0,397.47333333333336,3.686385792802001e-22,Metallophosphoesterase β-sheet core,True,assigned_too_few_test_positives +8400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-domain helical enzyme cores,False,no_term_above_threshold +8401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich basic low-complexity regions,False,no_term_above_threshold +8402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved N-terminal FAD-proximal motifs,False,no_term_above_threshold +8403,47529,17.014433,0.7475586,Immunoglobulin-like fold,interpro,88058,Signal,0.65722656,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8183288710397144,0.29041298825543227,0.007089056269384138,0.5,40.966382155781915,15.0,15.0,77.32944228274968,1.433530818057158e-28,Disulfide-rich N-terminal ectodomain cap,True,assigned_and_evaluated +8404,49121,19.311264,0.953125,"Signal transduction response regulator, C-terminal effector",interpro,37430,"Signal transduction response regulator, receiver domain",0.91064453,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,16.0,17.0,919.8997107039538,9.247017796858409e-47,HTH/AAA+ domain entry linker,True,assigned_too_few_test_positives +8405,42974,16.283455,0.9501953,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.89941406,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9996825396825397,0.8736394557823128,0.0031014621178555605,1.0,281.6863216715257,9.0,12.0,99.81194196428571,3.710143707816748e-17,Catalytic-loop HRD arginine,True,assigned_and_evaluated +8406,87149,17.971945,0.7026367,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.7026367,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8258588092033583,0.0598025370925309,0.012405848471422242,,4.820511650637223,0.0,19.0,0.0,1.0,Phospho-tuned polybasic membrane binders,True,assigned_and_evaluated +8407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coils with S/T/P-rich linkers,False,no_term_above_threshold +8408,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical scaffolds,False,no_term_above_threshold +8409,38873,15.674944,0.97216797,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9458008,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9903197158081705,0.28860028860028863,0.002215330084182543,0.4,130.2741702741703,15.0,17.0,151.16886409736307,1.2867747395053713e-31,ATPase Walker B/DExH motif,True,assigned_and_evaluated +8410,45324,16.581038,0.7949219,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.7949219,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.4920071047957371,0.002215330084182543,0.002215330084182543,,1.0,14.0,16.0,478.60894495412845,1.374908525618535e-36,Extracellular acidic glycine-rich loops,True,assigned_and_evaluated +8411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPGT-rich disordered scaffolds,False,no_term_above_threshold +8412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Valine-centered residue detector,False,no_term_above_threshold +8413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anaerobic Fe–S/corrinoid enzyme complexes,False,no_term_above_threshold +8414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Y-recombinase catalytic core activation,False,no_term_above_threshold +8415,50338,16.020071,0.734375,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.734375,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Metal coordinated phosphoryl transfer cores,True,assigned_too_few_test_positives +8416,55054,31.84499,0.9873047,HAD superfamily,interpro,55054,HAD superfamily,0.9873047,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.9991119005328597,0.8666666666666667,0.002215330084182543,0.8,391.21333333333337,20.0,20.0,334.9494382022472,1.0259108181878e-49,HAD cap beta-loop-alpha motif,True,assigned_and_evaluated +8417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic surface interaction patches,False,no_term_above_threshold +8418,85649,28.58869,0.9770508,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97314453,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9037211474835547,0.7484196632722899,0.0101905183872397,0.782608695652174,73.4427469567634,16.0,16.0,110.61410018552876,7.117153535323136e-33,Rossmann SAM MTase helix–β junction,True,assigned_and_evaluated +8419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GcvP2 conserved motif peaks,False,no_term_above_threshold +8420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal isoform variable regions,False,no_term_above_threshold +8421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding aromatic/basic patch,False,no_term_above_threshold +8422,85762,19.290182,0.96728516,FAD/NAD(P)-binding domain,gene3d,59224,Alpha/Beta hydrolase fold,0.93847656,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,0.0,18.0,0.0,1.0,Glycosyltransferase DxD-like acidic loop,True,assigned_too_few_test_positives +8423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface/coupling helices,False,no_term_above_threshold +8424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central acidic active-site segments,False,no_term_above_threshold +8425,64594,17.590458,0.8901367,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,29166,zinc ion binding,0.66552734,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9852156514006225,0.1255924185877016,0.003544528134692069,,35.432761094055316,0.0,19.0,0.0,1.0,Zinc-binding module initiation signal,True,assigned_and_evaluated +8426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine-rich IDRs,False,no_term_above_threshold +8427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-catalytic N-terminal cap,False,no_term_above_threshold +8428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-strand and loop hotspots,False,no_term_above_threshold +8429,52941,20.387718,0.99902344,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9902344,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,18.0,18.0,260.353711790393,2.623430428618387e-43,MFS transmembrane helix hydrophobes,True,assigned_too_few_test_positives +8430,88161,55.743538,0.7026367,Transmembrane helix,keyword,88161,Transmembrane helix,0.7026367,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6770044833698259,0.3699769792468026,0.1847585290208241,0.4460431654676259,2.0024893097362915,15.0,17.0,4.78896355993467,1.8200329607237112e-09,Transmembrane alpha helices,True,assigned_and_evaluated +8431,81858,19.361864,0.93115234,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.66503906,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,TM helix C-terminal interfaces,True,assigned_too_few_test_positives +8432,47529,18.004246,0.7109375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7109375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7057675145024542,0.09308688771510785,0.007089056269384138,,13.131069098312402,0.0,17.0,0.0,1.0,Extracellular glycosylated disulfide loops,True,assigned_and_evaluated +8433,82029,23.698101,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,18.0,188.0788643533123,6.824310871704072e-41,Secondary-active transporter TM helices,True,assigned_too_few_test_positives +8434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic cores and IDRs,False,no_term_above_threshold +8435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity IDRs,False,no_term_above_threshold +8436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzymatic alpha-helical residue signal,False,no_term_above_threshold +8437,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Boundary helices and TM anchors,False,no_term_above_threshold +8438,47529,23.619535,0.89990234,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.89990234,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.880563922356091,0.1818110757138206,0.007089056269384138,0.0625,25.64672486788082,2.0,18.0,8.592160253638852,0.03740996961272103,Ectodomain glycosylation hotspots,True,assigned_and_evaluated +8439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic nucleic-acid docking,False,no_term_above_threshold +8440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature catalytic chain C-terminal activation,False,no_term_above_threshold +8441,25169,16.203146,0.9272461,pilus,go_cc,88058,Signal,0.6953125,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.877708703374778,0.07017925834952006,0.002215330084182543,,31.678917218973357,1.0,19.0,29.055068226120856,0.0561877297732523,Sec-dependent signal peptides,True,assigned_and_evaluated +8442,87326,30.227509,0.67285156,Coiled coil,keyword,87326,Coiled coil,0.67285156,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6642895642439571,0.21984959817021582,0.03943287549844927,0.1797752808988764,5.575287000788507,15.0,18.0,10.50627334884049,4.501608829624033e-14,Acidic S/T/P-rich IDRs,True,assigned_and_evaluated +8443,37894,22.958103,0.91748047,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7631836,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Rossmann SDR pocket-lining segment,True,assigned_too_few_test_positives +8444,59224,23.840895,0.95703125,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7729492,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9746984126984127,0.29769586821202093,0.0031014621178555605,0.14285714285714285,95.98565350779018,19.0,19.0,137.37557603686636,1.4828928465544412e-40,ABHD helix N-cap motif,True,assigned_and_evaluated +8445,49230,16.030182,0.8979492,Acyl-CoA N-acyltransferase,interpro,88153,Transferase,0.6586914,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,16.0,0.0,1.0,Acidic-aromatic glycosidase cleft signature,True,assigned_too_few_test_positives +8446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic accessory interaction domains,False,no_term_above_threshold +8447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal OMP beta-barrel beta-signal,False,no_term_above_threshold +8448,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lectins and glycoside hydrolases,False,no_term_above_threshold +8449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-family sensory domain signature,False,no_term_above_threshold +8450,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interacting helical segments,False,no_term_above_threshold +8451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine-acidic catalytic patches,False,no_term_above_threshold +8452,64507,36.371063,0.9941406,Ankyrin repeat-containing domain superfamily,interpro,88009,Repeat,0.6582031,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997034400948992,0.9328843995510663,0.003987594151528578,1.0,233.94667664297296,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin repeat start detector,True,assigned_and_evaluated +8453,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular catalytic/ligand domains,False,no_term_above_threshold +8454,87522,30.13538,0.6972656,Glycoprotein,keyword,88161,Transmembrane helix,0.69140625,1135,keywords,Glycoprotein,keyword:keywords:Glycoprotein,89.0,2257.0,0.7876855383722378,0.28003773370687124,0.03943287549844927,0.1348314606741573,7.101631067150656,12.0,18.0,6.97199321756417,1.2481895523108282e-08,Cytosolic-biased TM helix–loop boundaries,True,assigned_and_evaluated +8455,87484,16.573135,0.6748047,G-protein coupled receptor,keyword,87484,G-protein coupled receptor,0.6748047,44,keywords,G-protein coupled receptor,keyword:keywords:G-protein coupled receptor,,,,,,,,0.0,11.0,0.0,1.0,N-terminal TM helix caps,True,assigned_too_few_test_positives +8456,82029,34.160484,1.0,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9951172,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS/SLC transmembrane helix cores,True,assigned_too_few_test_positives +8457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral structural and disordered regions,False,no_term_above_threshold +8458,37430,23.408596,1.0,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,1.0,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,14.0,14.0,484.7235772357723,7.836327138722209e-38,REC α4 output helix,True,assigned_too_few_test_positives +8459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered and cysteine-rich,False,no_term_above_threshold +8460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic loop-to-helix N-cap motif,False,no_term_above_threshold +8461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ciliary/meiotic charged coiled-coils,False,no_term_above_threshold +8462,87857,23.466684,0.6513672,Nucleus,keyword,87857,Nucleus,0.6513672,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.5966714260815938,0.11999705777441919,0.06247230837394772,0.014184397163120567,1.9208039673536461,16.0,18.0,5.385817524841915,6.977618722783658e-11,Acidic phospho-regulated IDR SLiMs,True,assigned_and_evaluated +8463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fold-type II PLP motif,False,no_term_above_threshold +8464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +8465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zn metalloprotease catalytic domain,False,no_term_above_threshold +8466,85656,16.34812,0.89941406,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.89941406,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9202222222222223,0.05586586574033107,0.0031014621178555605,,18.012751282275318,16.0,16.0,141.281990521327,1.474482880092783e-34,Active-site nucleophile elbow loops,True,assigned_and_evaluated +8467,81799,17.159307,0.8515625,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.64990234,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,2.0,17.0,68.09937178754997,0.0007048848942073787,Noncatalytic C-terminal stretches,True,assigned_too_few_test_positives +8468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domain scaffold cores,False,no_term_above_threshold +8469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UBC/T-box domain recognizer,False,no_term_above_threshold +8470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered terminal tails,False,no_term_above_threshold +8471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core scaffolds,False,no_term_above_threshold +8472,88163,15.846534,0.72558594,Transposable element,keyword,88163,Transposable element,0.72558594,122,keywords,Transposable element,keyword:keywords:Transposable element,11.0,2257.0,0.7974985833400794,0.18269298041125986,0.004873726185201595,0.09090909090909091,37.4852778898376,10.0,18.0,143.3886483886484,6.89904704490267e-20,Acidic metal-binding strand-loop motifs,True,assigned_and_evaluated +8473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory entry-helix linkers,False,no_term_above_threshold +8474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad N-terminal PIH1 activation,False,no_term_above_threshold +8475,87326,18.41481,0.61865234,Coiled coil,keyword,87326,Coiled coil,0.61865234,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6657277457606037,0.10547225930474016,0.03943287549844927,0.011235955056179775,2.6747290927056016,8.0,18.0,5.60334578604826,6.081376168324585e-05,Amphipathic interaction helix,True,assigned_and_evaluated +8476,4066,15.858048,0.79833984,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.79833984,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.5874777975133214,0.009464571759653727,0.002215330084182543,,4.272307692307693,0.0,17.0,0.0,1.0,Alpha/beta capsid oligomerization core,True,assigned_and_evaluated +8477,87149,22.043118,0.7241211,Amphibian defense peptide,keyword,87760,Membrane,0.60839844,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7330160866500031,0.1019608988136626,0.012405848471422242,,8.21877673651559,0.0,19.0,0.0,1.0,Charged disordered targeting segments,True,assigned_and_evaluated +8478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral helices with cysteine peaks,False,no_term_above_threshold +8479,87882,40.738667,0.9013672,Palmitate,keyword,87735,Lipoprotein,0.7817383,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9975566414926699,0.4150312650312651,0.002658396101019052,0.8333333333333334,156.12092752926088,18.0,20.0,59.954078212290504,9.18530610399521e-31,Post cleavage disordered linker,True,assigned_and_evaluated +8480,88007,19.415827,0.86083984,Redox-active center,keyword,64016,Thioredoxin-like superfamily,0.8364258,39,keywords,Redox-active center,keyword:keywords:Redox-active center,,,,,,,,0.0,11.0,0.0,1.0,Redox/metal cofactor domain scaffold,True,assigned_too_few_test_positives +8481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic interaction module,False,no_term_above_threshold +8482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"IDR, secreted peptides, short helices",False,no_term_above_threshold +8483,61392,25.90457,1.0,Leucine-rich repeat domain superfamily,interpro,63831,F-box-like domain superfamily,0.91552734,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9996825396825397,0.8736394557823128,0.0031014621178555605,1.0,281.6863216715257,12.0,12.0,167.4747191011236,5.548442140483082e-27,LRR C-terminal hydrophobic anchor,True,assigned_and_evaluated +8484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Pro-rich disordered linkers,False,no_term_above_threshold +8485,64148,33.943314,0.8413086,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.79003906,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8531583650816049,0.1572977923306528,0.008418254319893664,,18.685321962646494,5.0,14.0,31.78091684434968,6.325660902665579e-07,Beta-alpha wing motif,True,assigned_and_evaluated +8486,59211,19.537727,0.75927734,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.75927734,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.7148028673835126,0.15199764834918608,0.011076650420912717,,13.722347692964519,0.0,15.0,0.0,1.0,Oxyanion-binding pocket rim,True,assigned_and_evaluated +8487,87857,21.822155,0.6196289,Nucleus,keyword,87857,Nucleus,0.6196289,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6275020445373982,0.1946278128810339,0.06247230837394772,0.14893617021276595,3.1154253451949896,17.0,18.0,5.722431120144535,1.6572984806519585e-12,Charge-rich coiled-coil linkers,True,assigned_and_evaluated +8488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ala/Thr-rich N-terminal disorder,False,no_term_above_threshold +8489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Sec/Tat signal peptides,False,no_term_above_threshold +8490,63831,22.256943,0.9692383,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9692383,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.904338812379683,0.0150202348094248,0.002658396101019052,,5.650111660811962,0.0,15.0,0.0,1.0,NTPase active-site catalytic residue,True,assigned_and_evaluated +8491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDRs with MoRF-like helices,False,no_term_above_threshold +8492,38873,16.024439,0.79589844,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6323242,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7930728241563055,0.2603064218887455,0.002215330084182543,0.4,117.50231884057972,11.0,12.0,157.047653256705,7.991933597734102e-24,P-loop NTPase N-terminal accessory segments,True,assigned_and_evaluated +8493,87317,20.567131,0.86035156,Cleavage on pair of basic residues,keyword,88058,Signal,0.73583984,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9555443998215083,0.24351506341411305,0.007089056269384138,,34.350843632853326,2.0,18.0,9.383223166509286,0.031865022652522924,Post-signal disordered propeptides,True,assigned_and_evaluated +8494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical hydrophobic packing,False,no_term_above_threshold +8495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HTH-adjacent dimerization helix,False,no_term_above_threshold +8496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity pre/propeptides,False,no_term_above_threshold +8497,88263,18.751635,0.6020508,Zinc-finger,keyword,88263,Zinc-finger,0.6020508,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.6171381076956617,0.04593805255759986,0.014621178555604785,,3.1418843825000877,12.0,16.0,19.543597027972027,3.5959584691334276e-14,Disordered low-complexity flanks,True,assigned_and_evaluated +8498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction segments,False,no_term_above_threshold +8499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active-site tails,False,no_term_above_threshold +8500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered regions and active-site peaks,False,no_term_above_threshold +8501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic C-terminal tails,False,no_term_above_threshold +8502,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered phospho-regulatory tails,False,no_term_above_threshold +8503,38317,19.35297,0.7319336,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7319336,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6353968253968254,0.018133697431121316,0.0031014621178555605,,5.846822157434402,0.0,18.0,0.0,1.0,Exposed polar noncatalytic surfaces,True,assigned_and_evaluated +8504,88058,20.772223,0.62841797,Signal,keyword,88058,Signal,0.62841797,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6331247366901299,0.13636566924641944,0.09127159946832078,,1.4940646382969354,6.0,19.0,2.275248847193512,0.06387835227892309,Boundary/turn microenvironment signature,True,assigned_and_evaluated +8505,50869,18.971704,0.9213867,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.9213867,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,17.0,0.0,1.0,Metal-dependent nucleotide phosphohydrolases,True,assigned_too_few_test_positives +8506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alternative splicing boundary marker,False,no_term_above_threshold +8507,64148,35.02567,0.83691406,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.83691406,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9414185598043366,0.6284848037793502,0.008418254319893664,0.5789473684210527,74.65737905947334,19.0,19.0,88.9865671641791,4.383349844353145e-37,N-terminal HTH recognition helix,True,assigned_and_evaluated +8508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase catalytic cores,False,no_term_above_threshold +8509,38317,19.236803,0.9604492,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9604492,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9606349206349206,0.04107141152172889,0.0031014621178555605,,13.242596543506016,0.0,15.0,0.0,1.0,Cross-domain catalytic core signature,True,assigned_and_evaluated +8510,85649,22.629942,0.97021484,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96972656,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9691331594721888,0.7776117036640601,0.0101905183872397,0.782608695652174,76.30737457259929,14.0,17.0,91.09396485867073,4.3158956278612996e-26,Aromatic beta-strand start motif,True,assigned_and_evaluated +8511,36914,18.796741,0.9238281,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.84521484,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,GT C-terminal helical/TM tails,True,assigned_too_few_test_positives +8512,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-helix glycan-binding adhesins,False,no_term_above_threshold +8513,85672,20.646135,0.640625,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.640625,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6859335134323877,0.23268666722990794,0.01595037660611431,0.16666666666666666,14.588161331608395,16.0,18.0,35.56808351976137,9.111558536319882e-24,NTPase coupling/interface loops,True,assigned_and_evaluated +8514,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core scaffolding segments,False,no_term_above_threshold +8515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclin-like helical interaction fold,False,no_term_above_threshold +8516,64148,18.531576,0.6508789,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6508789,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5133813084991298,0.034290977776741366,0.008418254319893664,0.05263157894736842,4.073407202216067,12.0,18.0,59.32437810945273,1.6458679506894985e-19,DNA and cofactor phosphate recognition,True,assigned_and_evaluated +8517,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-motif beta-strand element,False,no_term_above_threshold +8518,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory terminal nuclease tails,False,no_term_above_threshold +8519,87489,16.689764,0.73535156,GPI-anchor,keyword,87522,Glycoprotein,0.61328125,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.629015873015873,0.029226134405911233,0.0031014621178555605,,9.423340764877379,0.0,13.0,0.0,1.0,P/S/T-rich disordered juxtamembrane stalks,True,assigned_and_evaluated +8520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal sensor-coupling leaders,False,no_term_above_threshold +8521,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular ectodomains and IDRs,False,no_term_above_threshold +8522,87697,16.274397,0.7998047,Knottin,keyword,87413,Disulfide bond,0.6894531,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9083026982035096,0.08145309719181937,0.017279574656623838,,4.713836932357341,0.0,17.0,0.0,1.0,Flexible domain boundary linkers,True,assigned_and_evaluated +8523,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity tandem repeats,False,no_term_above_threshold +8524,37341,24.54756,0.9921875,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9916992,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9980651054642086,0.7850375429811112,0.011962782454585734,1.0,65.62332350030992,7.0,19.0,53.574711168164306,6.906975527179081e-11,β-propeller blade strand/linker motif,True,assigned_and_evaluated +8525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich beta-hairpin cap,False,no_term_above_threshold +8526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser-rich secretory IDRs,False,no_term_above_threshold +8527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed periplasmic low-complexity coils,False,no_term_above_threshold +8528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended surface interaction segments,False,no_term_above_threshold +8529,85649,31.041147,0.97802734,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9741211,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9719940835311978,0.7997549168813842,0.0101905183872397,0.782608695652174,78.4802977130993,17.0,18.0,104.46887239744382,1.1788152737018052e-33,SAM-binding β-strand submotif,True,assigned_and_evaluated +8530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-coil tails,False,no_term_above_threshold +8531,37097,20.56452,0.97753906,Cro/C1-type helix-turn-helix domain,interpro,87384,DNA-binding,0.6298828,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,19.0,0.0,1.0,Secondary structure capping hinge motif,True,assigned_too_few_test_positives +8532,47128,16.450867,0.93847656,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.93847656,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,2.0,18.0,28.554118773946357,0.0038426924801370785,Extracellular beta-rich binding interface,True,assigned_too_few_test_positives +8533,85672,19.096827,0.77441406,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.76416016,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8007904347391066,0.06977762975034704,0.01595037660611431,,4.3746697318481464,0.0,18.0,0.0,1.0,HAD phosphatase cap-domain motif,True,assigned_and_evaluated +8534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal start site detector,False,no_term_above_threshold +8535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered terminal hydrophobic motif,False,no_term_above_threshold +8536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal disordered C-terminal tails,False,no_term_above_threshold +8537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RBR TRIAD supradomain activation,False,no_term_above_threshold +8538,80926,16.212292,0.81689453,Homeodomain-like,gene3d,87149,Amphibian defense peptide,0.6894531,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.877468120115179,0.04589625725959248,0.0057598582188746125,,7.968296356530787,0.0,19.0,0.0,1.0,Sigma-70 region-2 helical scaffold,True,assigned_and_evaluated +8539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TPS core with motif dips,False,no_term_above_threshold +8540,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosidase N-terminal glycone subsites,False,no_term_above_threshold +8541,31094,15.799352,0.94970703,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8232422,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9435469514908766,0.21622088536175776,0.004430660168365086,,48.80105382614873,0.0,20.0,0.0,1.0,Binding loops and coiled-coil interfaces,True,assigned_and_evaluated +8542,83302,18.851938,0.9638672,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9589844,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9802881891038614,0.24016585409002353,0.004873726185201595,,49.27766660738028,6.0,15.0,82.23586206896552,1.281801298761824e-10,Beta-strand conservation peaks,True,assigned_and_evaluated +8543,64058,25.058613,0.6713867,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.66552734,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.5702821476339086,0.14817393505918097,0.006202924235711121,0.14285714285714285,23.887755102040817,15.0,15.0,113.99808795411089,4.589611073054062e-31,SDR/CAR Rossmann beta-alpha module,True,assigned_and_evaluated +8544,36091,18.69884,0.9868164,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9785156,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,10.0,0.0,1.0,ABC NBD hydrophobic beta-strands,True,assigned_too_few_test_positives +8545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminus accessibility sensor,False,no_term_above_threshold +8546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic helical patches,False,no_term_above_threshold +8547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GINS C-terminal helical bundle,False,no_term_above_threshold +8548,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-sandwich recognition,False,no_term_above_threshold +8549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil hinge junctions,False,no_term_above_threshold +8550,36914,20.349478,0.98095703,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9375,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,19.0,658.5815464587395,1.5489397236913889e-46,Glycosyltransferase acceptor site helix,True,assigned_too_few_test_positives +8551,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix–loop junctions,False,no_term_above_threshold +8552,36091,24.320927,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9995117,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,19.0,357.48767488341105,5.778092987514223e-45,Acyltransferase beta-hairpin scaffold,True,assigned_too_few_test_positives +8553,48767,21.46764,0.99316406,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.9790039,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,18.0,0.0,1.0,OB-like nucleic acid binding loops,True,assigned_too_few_test_positives +8554,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage tail-assembly and structural proteins,False,no_term_above_threshold +8555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended binding interface regions,False,no_term_above_threshold +8556,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclase catalytic scaffold helix,False,no_term_above_threshold +8557,81858,20.549725,0.9345703,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.9345703,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,17.0,17.0,261.4956140350877,4.358104152891723e-41,Polytopic alpha-helical membrane domains,True,assigned_too_few_test_positives +8558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FERM F3 subdomain activation,False,no_term_above_threshold +8559,37020,16.283598,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.97998047,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,20.0,735.0534246575343,7.320908339078854e-50,Glycosyltransferase FxP acceptor loop,True,assigned_too_few_test_positives +8560,30398,18.782082,0.68359375,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6411133,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.5844126932728891,0.04035123051516494,0.004873726185201595,,8.279338842975207,12.0,18.0,48.004025764895324,2.040697834722003e-18,Conserved NTPase head loops,True,assigned_and_evaluated +8561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand/loop core scaffold,False,no_term_above_threshold +8562,25167,18.948345,0.68359375,cell outer membrane,go_cc,25167,cell outer membrane,0.68359375,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.8310876020786934,0.6023013645964466,0.005316792202038104,0.6666666666666666,113.28284832451499,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel signature,True,assigned_and_evaluated +8563,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface beta-sandwich interfaces,False,no_term_above_threshold +8564,59229,31.27165,0.9824219,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9824219,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9738332489977035,0.8379042350019278,0.0101905183872397,0.9130434782608695,82.2239068869283,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Motif I SAM-binding loop,True,assigned_and_evaluated +8565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered membrane terminal tails,False,no_term_above_threshold +8566,63774,17.579512,0.9355469,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.9355469,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,19.0,0.0,1.0,C-terminal helices in FAD oxidoreductases,True,assigned_too_few_test_positives +8567,63831,31.147713,0.87597656,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.87597656,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9977787649933363,0.4112433862433863,0.002658396101019052,0.8333333333333334,154.69605379188712,0.0,20.0,0.0,1.0,G-patch/RS RNA-binding patches,True,assigned_and_evaluated +8568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cleft lid-loop,False,no_term_above_threshold +8569,63951,17.407646,0.8261719,Immunoglobulin-like domain superfamily,interpro,85388,Glutaredoxin,0.66259766,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8826117042309213,0.1837193482002225,0.003987594151528578,,46.07272987643358,0.0,15.0,0.0,1.0,ER luminal redox/glycosylation signature,True,assigned_and_evaluated +8570,88009,25.76129,0.69677734,Repeat,keyword,88009,Repeat,0.69677734,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.8078306899886963,0.22090926445083348,0.07266282676118742,0.036585365853658534,3.0401964016190925,7.0,19.0,3.2662649188025825,0.005881200124555397,Hydrophobic/aromatic IDR-linker signal,True,assigned_and_evaluated +8571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic electrostatic interface patches,False,no_term_above_threshold +8572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered tails and linkers,False,no_term_above_threshold +8573,43583,17.607353,0.94433594,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.94433594,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,13.0,14.0,387.14935064935065,3.181492804924155e-33,Serine protease Asp-centered core,True,assigned_and_evaluated +8574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDRs and MOB-like domains,False,no_term_above_threshold +8575,36776,19.244081,0.97558594,SANT/Myb domain,interpro,47529,Immunoglobulin-like fold,0.77490234,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9966681474900045,0.29844599844599845,0.002658396101019052,,112.26543641543641,0.0,17.0,0.0,1.0,Conserved beta-sandwich Trp anchor,True,assigned_and_evaluated +8576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal phosphate-binding loop-strand,False,no_term_above_threshold +8577,49045,17.891365,0.9946289,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96191406,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,15.0,17.0,478.24331550802134,3.750835555630155e-39,Beta-propeller blade loop repeats,True,assigned_too_few_test_positives +8578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TPR repeat scaffolds,False,no_term_above_threshold +8579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal cofactor-binding catalytic domains,False,no_term_above_threshold +8580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxyanion/phosphate-binding active-site region,False,no_term_above_threshold +8581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GlcNAc glycan-degrading domains,False,no_term_above_threshold +8582,36354,23.702415,0.8808594,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.85839844,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,13.0,0.0,1.0,REC α2 helix E/D-A motif,True,assigned_too_few_test_positives +8583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal secretory helices,False,no_term_above_threshold +8584,63951,20.998125,0.9760742,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9135742,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9977263740608937,0.5454311120977787,0.003987594151528578,0.8888888888888888,136.78200222274296,10.0,17.0,94.78696343402227,3.487146599123296e-18,Ig/FN3 strand-entry loops,True,assigned_and_evaluated +8585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SMC/Rad50 coiled-coil stalks,False,no_term_above_threshold +8586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal ligand-anchoring modules and tails,False,no_term_above_threshold +8587,83419,21.371122,0.99121094,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9790039,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,17.0,19.0,325.2750320924262,2.2070817398232315e-41,HxCxxW beta-strand motif,True,assigned_too_few_test_positives +8588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly interface segments,False,no_term_above_threshold +8589,36668,15.614751,0.93603516,AMP-dependent synthetase/ligase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.734375,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,15.0,0.0,1.0,Walker A P-loop motif,True,assigned_too_few_test_positives +8590,37690,28.167757,0.8798828,Ankyrin repeat,interpro,82608,Ankyrin repeat-containing domain,0.8666992,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9185079365079365,0.2557399619786941,0.0031014621178555605,0.14285714285714285,82.45787059798751,13.0,13.0,180.66969696969696,1.3402573090464467e-29,Phospho-rich disordered scaffold linkers,True,assigned_and_evaluated +8591,36104,19.125486,0.9765625,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9765625,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Catalytic N-terminal cap,True,assigned_too_few_test_positives +8592,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal assembly interface segments,False,no_term_above_threshold +8593,25169,16.144276,0.8203125,pilus,go_cc,47529,Immunoglobulin-like fold,0.7446289,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9925399644760213,0.14818506493506492,0.002215330084182543,,66.89073831168831,0.0,18.0,0.0,1.0,Ectodomain beta-strand/loop bias,True,assigned_and_evaluated +8594,85672,16.986893,0.73291016,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.71777344,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7955875731652409,0.04572890210473644,0.01595037660611431,,2.8669481125108374,0.0,14.0,0.0,1.0,TPS TIM-barrel conserved cysteine,True,assigned_and_evaluated +8595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-patatin IQxRLAYV motif,False,no_term_above_threshold +8596,87697,19.756044,0.9165039,Knottin,keyword,87413,Disulfide bond,0.8774414,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9915262074865321,0.5160519583383474,0.017279574656623838,0.8461538461538461,29.864853076144872,0.0,11.0,0.0,1.0,Extracellular cysteine-rich repeats,True,assigned_and_evaluated +8597,36010,16.157665,0.9897461,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9760742,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,16.0,0.0,1.0,Abhydrolase_1 core beta-strand,True,assigned_too_few_test_positives +8598,10369,19.897078,0.7583008,DNA integration,go_bp,10369,DNA integration,0.7583008,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,5.0,18.0,151.93934760448522,3.272141924785821e-10,Secondary-structure junction motifs,True,assigned_too_few_test_positives +8599,88161,52.232708,0.6503906,Transmembrane helix,keyword,88161,Transmembrane helix,0.6503906,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.709320587008654,0.5223506169811113,0.1847585290208241,0.5035971223021583,2.8272070564181493,13.0,14.0,5.039814032121725,6.6239830674169e-09,Cytosolic membrane-interface segments,True,assigned_and_evaluated +8600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand/loop transition motif,False,no_term_above_threshold +8601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet interior hydrophobics,False,no_term_above_threshold +8602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TFIIIC/TAF1 core activation,False,no_term_above_threshold +8603,82029,28.567888,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9951172,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS helical-face signature,True,assigned_too_few_test_positives +8604,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core or TM segments,False,no_term_above_threshold +8605,36535,18.441679,0.9423828,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.93652344,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9471962616822429,0.9004430660168365,0.004430660168365086,0.9,203.23000000000002,11.0,11.0,89.79066265060241,8.231873136338666e-22,Terminal kinase C-lobe helix,True,assigned_and_evaluated +8606,85682,32.00836,0.8730469,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8730469,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9764247311827957,0.7870377645975228,0.011076650420912717,0.92,71.05376938786436,15.0,15.0,102.26586620926243,2.302639508687674e-30,Rossmann-like dinucleotide-binding loop,True,assigned_and_evaluated +8607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtadomain signal-relay linkers,False,no_term_above_threshold +8608,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transposase-derived internal motif,False,no_term_above_threshold +8609,64085,29.03673,0.96191406,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.95996094,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9955297058258028,0.5884905725927505,0.012405848471422242,0.9642857142857143,47.43654365506564,0.0,13.0,0.0,1.0,Repeat-domain surface loops,True,assigned_and_evaluated +8610,36449,20.23314,1.0,EamA domain,interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.78515625,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,13.0,17.0,814.1523109243697,1.3729187257390147e-36,Glycine-rich transporter TM helices,True,assigned_too_few_test_positives +8611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Selective core transporter TM helices,False,no_term_above_threshold +8612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant TF disordered termini,False,no_term_above_threshold +8613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed SLiM loops,False,no_term_above_threshold +8614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/acidic beta-loop onset module,False,no_term_above_threshold +8615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix–loop junctions,False,no_term_above_threshold +8616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribosyl cyclase Pro-Cys disulfide,False,no_term_above_threshold +8617,55054,24.848011,0.9873047,HAD superfamily,interpro,55054,HAD superfamily,0.9873047,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.9958259325044405,0.8192307692307692,0.002215330084182543,0.8,369.8007692307692,19.0,19.0,334.9494382022472,1.6151862494317167e-47,HAD KPD Mg2+-Asp segment,True,assigned_and_evaluated +8618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse TM-boundary loop motifs,False,no_term_above_threshold +8619,64599,19.573307,0.94677734,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.94677734,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,0.0,17.0,0.0,1.0,Acidic gly/ser-rich DG motifs,True,assigned_too_few_test_positives +8620,36104,25.378864,0.99365234,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99365234,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Conserved internal alpha-helix motif,True,assigned_too_few_test_positives +8621,25169,24.008614,0.89697266,pilus,go_cc,25169,pilus,0.89697266,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8973801065719361,0.48877639935016987,0.002215330084182543,0.4,220.6336666666667,9.0,17.0,292.2598039215686,9.507650930809166e-21,Fimbrial receptor-binding domains,True,assigned_and_evaluated +8622,59224,17.954977,0.8779297,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8413086,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9600000000000001,0.06348155106595715,0.0031014621178555605,,20.46826582226647,0.0,11.0,0.0,1.0,Helix-capping serine motif,True,assigned_and_evaluated +8623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad disordered linker activation,False,no_term_above_threshold +8624,84612,16.34099,0.88378906,"Knottin, scorpion toxin-like",gene3d,64317,"Knottin, scorpion toxin-like superfamily",0.8432617,34,gene3d,3.30.30.10,gene3d:gene3d:3.30.30.10,,,,,,,,0.0,12.0,0.0,1.0,N-terminal domain-start transition,True,assigned_too_few_test_positives +8625,47529,33.32912,0.98583984,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.98583984,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9978525211958947,0.7427238882226305,0.007089056269384138,0.9375,104.77048848240482,18.0,18.0,77.32944228274968,4.066396380554961e-34,Ectodomain repeat C-terminal beta-strand,True,assigned_and_evaluated +8626,52236,24.185596,0.99853516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9970703,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR A-helix boundary register,True,assigned_too_few_test_positives +8627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core scaffold segments,False,no_term_above_threshold +8628,49045,21.174484,0.9892578,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7685547,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,13.0,0.0,1.0,β-propeller catalytic ectodomains,True,assigned_too_few_test_positives +8629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine recombinase DNA-binding helix,False,no_term_above_threshold +8630,85672,22.471115,0.60253906,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.60253906,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6479876432037621,0.28085925978685544,0.01595037660611431,0.2777777777777778,17.6083152594148,13.0,13.0,40.01409395973155,3.774017721320684e-21,NTPase C-terminal effector lobe,True,assigned_and_evaluated +8631,38317,19.749794,0.80615234,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7363281,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6366666666666666,0.04859751932351464,0.0031014621178555605,,15.66922873045322,0.0,19.0,0.0,1.0,Conserved helical motif peaks,True,assigned_and_evaluated +8632,59224,28.5154,0.9711914,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9711914,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,17.0,17.0,137.37557603686636,1.8959130288093467e-36,AB hydrolase pre-nucleophile strand,True,assigned_and_evaluated +8633,49061,22.470253,0.9941406,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9941406,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.999559379606486,0.96329947637059,0.012405848471422242,1.0,77.64881850601506,18.0,20.0,88.9865671641791,8.468392540819509e-34,WD-repeat blade strand residues,True,assigned_and_evaluated +8634,82029,34.77626,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,C-terminal TM helix-loop junctions,True,assigned_too_few_test_positives +8635,45553,15.743022,0.78759766,Restriction endonuclease type II-like,interpro,9276,DNA restriction-modification system,0.70654297,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,0.0,17.0,0.0,1.0,C-terminal structured domain activation,True,assigned_too_few_test_positives +8636,38317,18.824091,0.7939453,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7939453,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6119999999999999,0.008543787393032009,0.0031014621178555605,,2.754761163724749,0.0,19.0,0.0,1.0,Charged disordered regulatory tails,True,assigned_and_evaluated +8637,36010,17.377472,0.9868164,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97265625,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,16.0,0.0,1.0,ABH pre-Ser nucleophile elbow,True,assigned_too_few_test_positives +8638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribose/NAD+ catalytic cleft,False,no_term_above_threshold +8639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic alpha-helical interfaces,False,no_term_above_threshold +8640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical interaction motifs and IDRs,False,no_term_above_threshold +8641,36104,18.9823,0.89941406,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.89941406,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,11.0,0.0,1.0,SEC14/CRAL-TRIO lipid-binding domains,True,assigned_too_few_test_positives +8642,37468,18.16845,0.96972656,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.90966797,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,4.0,19.0,28.92117390249818,1.8372583631526476e-05,Short basic disordered loops,True,assigned_too_few_test_positives +8643,49236,18.619171,0.86816406,C-type lectin fold,interpro,49236,C-type lectin fold,0.86816406,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,18.0,18.0,542.0090909090909,9.077238758683182e-49,Surface ligand-recognition loops,True,assigned_and_evaluated +8644,59218,21.253359,0.80029297,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.80029297,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,14.0,16.0,487.5549065420561,1.0498063406239337e-36,Metal-coordinated catalytic domains,True,assigned_too_few_test_positives +8645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal amphipathic tails,False,no_term_above_threshold +8646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme accessory beta-domains,False,no_term_above_threshold +8647,64003,25.89695,0.99902344,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.9863281,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,130.4617067833698,4.534127311811392e-36,C2H2 helix end signature,True,assigned_and_evaluated +8648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding active-site flanks,False,no_term_above_threshold +8649,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical lid interface,False,no_term_above_threshold +8650,36104,17.094126,0.98095703,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.98095703,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Aromatic wedge binding patches,True,assigned_too_few_test_positives +8651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CXXCH-flanking interheme linkers,False,no_term_above_threshold +8652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase-biased P-loop motor signature,False,no_term_above_threshold +8653,72011,19.727758,0.9902344,"AMP-binding enzyme, C-terminal domain superfamily",interpro,37640,EF-hand domain,0.8129883,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,6.0,0.0,1.0,ABC NBD Q-loop/switch helix,True,assigned_too_few_test_positives +8654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory regions,False,no_term_above_threshold +8655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged surface loop motifs,False,no_term_above_threshold +8656,37894,20.304853,0.9550781,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7939453,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Rossmann-like substrate-binding strand-loop-helix patch,True,assigned_too_few_test_positives +8657,37640,24.64349,0.9980469,EF-hand domain,interpro,46081,EF-hand domain pair,0.9916992,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,17.0,19.0,268.0658555937583,5.687667946748188e-40,EF-hand Ca2+-sensor regions,True,assigned_too_few_test_positives +8658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible catalytic loops and flanks,False,no_term_above_threshold +8659,59224,21.308485,0.95703125,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.95703125,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9870476190476191,0.19601769494750768,0.0031014621178555605,0.14285714285714285,63.2017053566464,3.0,14.0,29.43762343647136,0.0002387395427486687,Active-site cap helix,True,assigned_and_evaluated +8660,87697,18.936367,0.8022461,Knottin,keyword,87697,Knottin,0.8022461,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7208388245358488,0.02941343881203771,0.017279574656623838,,1.702208497404336,0.0,13.0,0.0,1.0,Beta-sheet hydrophobic hotspots,True,assigned_and_evaluated +8661,61392,17.69763,0.89746094,Leucine-rich repeat domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.73535156,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.7793650793650795,0.012380530538687361,0.0031014621178555605,,3.991836775116768,2.0,17.0,19.702908129543953,0.007845193848110561,Active-site rim loops,True,assigned_and_evaluated +8662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C terminal domain exit hotspots,False,no_term_above_threshold +8663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic proline-rich Trp-anchored C-terminus,False,no_term_above_threshold +8664,81858,16.436852,0.86279297,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6665039,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,10.0,0.0,1.0,Dominant hydrophobic transmembrane helix core,True,assigned_too_few_test_positives +8665,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved domain-edge hydrophobic loop,False,no_term_above_threshold +8666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed alpha-helical stalks,False,no_term_above_threshold +8667,72011,17.237906,0.9736328,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.94921875,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,Polar C-terminal helix-loop cap,True,assigned_too_few_test_positives +8668,46079,17.728664,0.85791016,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.85791016,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.7861305361305362,0.030081955235676677,0.0057598582188746125,,5.222690228224789,0.0,18.0,0.0,1.0,Aromatic residues in helices,True,assigned_and_evaluated +8669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane disorder with TM hotspots,False,no_term_above_threshold +8670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal HATC dimerization motif,False,no_term_above_threshold +8671,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular adhesive glycan-binding regions,False,no_term_above_threshold +8672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic lid,False,no_term_above_threshold +8673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal kinase juxtadomain segments,False,no_term_above_threshold +8674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical bundle cores,False,no_term_above_threshold +8675,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane interface linkers,False,no_term_above_threshold +8676,88161,23.235441,0.6220703,Transmembrane helix,keyword,88161,Transmembrane helix,0.6220703,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7257142112397039,0.4910256523546426,0.1847585290208241,0.4844124700239808,2.657661624375128,10.0,13.0,4.174993872763559,1.3913292202042656e-05,Transmembrane helix interface signature,True,assigned_and_evaluated +8677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH catalytic core signature,False,no_term_above_threshold +8678,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP DD-transpeptidase active-site loops,False,no_term_above_threshold +8679,43624,21.708965,0.9213867,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.9213867,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.9097640562248996,0.13452413534010937,0.007089056269384138,,18.97631084141418,6.0,16.0,32.92765095729013,3.1022297229781136e-08,C-terminal domain boundary marker,True,assigned_and_evaluated +8680,87856,15.803939,0.71972656,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.71972656,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5310677433826828,0.043662573580606365,0.012405848471422242,0.03571428571428571,3.519515306122449,14.0,14.0,84.68892045454545,2.9630149843605392e-27,Polymerase palm catalytic core,True,assigned_and_evaluated +8681,85762,21.370092,0.93603516,FAD/NAD(P)-binding domain,gene3d,87873,Oxidoreductase,0.6376953,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,12.0,17.0,145.12210953346857,2.4993456050755077e-24,Phosphate-binding cofactor loops,True,assigned_too_few_test_positives +8682,82029,30.763018,0.93603516,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.92822266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,16.0,176.32393533123027,3.987569342785294e-33,SLCO/OATP Kazal-like glyco-disulfide loop,True,assigned_too_few_test_positives +8683,37341,21.863102,0.99560547,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9921875,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9995681780435144,0.9403955726369444,0.011962782454585734,1.0,78.61010397931791,0.0,18.0,0.0,1.0,Propeller-blade loop connectors,True,assigned_and_evaluated +8684,59211,17.999887,0.92529297,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.92529297,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9776164874551971,0.3706652517350789,0.011076650420912717,0.2,33.46365892664292,17.0,17.0,244.34836065573774,1.3495568203358695e-40,Glycosyltransferase donor-binding loop,True,assigned_and_evaluated +8685,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic membrane-interfacial microdomains,False,no_term_above_threshold +8686,38317,20.5736,0.95458984,Pentatricopeptide repeat,interpro,88009,Repeat,0.67578125,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9831746031746031,0.10546164860614779,0.0031014621178555605,,34.003848700582225,0.0,18.0,0.0,1.0,Tandem repeat PPI scaffolds,True,assigned_and_evaluated +8687,36091,20.386526,0.94189453,GNAT domain,interpro,27918,DNA-binding transcription factor activity,0.6845703,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,19.0,0.0,1.0,HTH helix-turn C-cap motif,True,assigned_too_few_test_positives +8688,87326,30.590021,0.66552734,Coiled coil,keyword,87326,Coiled coil,0.66552734,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6602626559973466,0.17242902779535854,0.03943287549844927,0.15730337078651685,4.3727226486980255,13.0,18.0,9.105436902328423,6.046143033298259e-11,Coiled-coil oligomerization segments,True,assigned_and_evaluated +8689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic domain-boundary scaffolds,False,no_term_above_threshold +8690,38873,23.373592,0.98291016,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8964844,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9972468916518651,0.7072100313479623,0.002215330084182543,0.6,319.23460815047025,13.0,13.0,171.32471264367817,2.6588953672088044e-29,ABC NBD pre-Walker A motif,True,assigned_and_evaluated +8691,63774,15.974044,0.89453125,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.89453125,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,18.0,0.0,1.0,Tudor-domain piRNA/germline readers,True,assigned_too_few_test_positives +8692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding loops,False,no_term_above_threshold +8693,38317,15.665961,0.6743164,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.6743164,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.49377777777777776,0.0031014621178555605,0.0031014621178555605,,1.0,0.0,17.0,0.0,1.0,Broad mature-chain activation of LDTs,True,assigned_and_evaluated +8694,87857,25.082867,0.67626953,Nucleus,keyword,87857,Nucleus,0.67626953,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6365415811983001,0.1376206577300646,0.06247230837394772,,2.2029065567145802,18.0,20.0,5.453140243902439,2.419493338193273e-12,Acidic S/T-rich IDRs,True,assigned_and_evaluated +8695,88009,33.848217,0.73583984,Repeat,keyword,88009,Repeat,0.73583984,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.8195684220339575,0.35178250645551473,0.07266282676118742,0.31097560975609756,4.841299494329858,11.0,12.0,8.126778190830235,8.33439908014195e-10,EGF/TB repeat loop motifs,True,assigned_and_evaluated +8696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-linked glycan transferases,False,no_term_above_threshold +8697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved selectivity hotspot motifs,False,no_term_above_threshold +8698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT-like RNA polymerase core,False,no_term_above_threshold +8699,47529,29.905598,0.9711914,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9711914,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9969321731369924,0.7234957865913405,0.007089056269384138,0.75,102.05812439604097,16.0,19.0,65.11953034336815,1.6340624439516e-27,FN3/Ig interaction loop hotspots,True,assigned_and_evaluated +8700,37576,17.90804,0.9921875,"Zinc finger, PHD-type",interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9116211,31,ip,IPR001965,interpro:ip:IPR001965,,,,,,,,0.0,7.0,0.0,1.0,Extended low-complexity regions,True,assigned_too_few_test_positives +8701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal membrane-proximal amphipathic segments,False,no_term_above_threshold +8702,83302,17.99565,0.71240234,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.7055664,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.6734598882862463,0.14248228331685858,0.004873726185201595,0.09090909090909091,29.234773949649988,2.0,13.0,31.629177718832892,0.0030908999581565977,Exposed β-loop binding patches,True,assigned_and_evaluated +8703,48767,16.329844,0.7050781,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.7050781,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,14.0,0.0,1.0,RelA/SpoT central interdomain detector,True,assigned_too_few_test_positives +8704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-strand module,False,no_term_above_threshold +8705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal and domain edge motifs,False,no_term_above_threshold +8706,87276,25.304113,0.6767578,Cell membrane,keyword,88161,Transmembrane helix,0.6738281,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8071721091704965,0.40012432772538004,0.11120957022596367,0.5657370517928287,3.597930707873238,7.0,15.0,3.8292228644829804,0.0018398556591574554,Oxidase subunit 3 loop-helix interfaces,True,assigned_and_evaluated +8707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular adhesion/glycan-processing domains,False,no_term_above_threshold +8708,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like SAM MTase core,False,no_term_above_threshold +8709,85364,27.900467,0.9458008,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9458008,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,18.0,301.1161616161616,2.0260096530472245e-44,Venus flytrap ligand-binding lobe,True,assigned_too_few_test_positives +8710,85672,20.34956,0.7890625,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7753906,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8492545900245135,0.16721035719261315,0.01595037660611431,0.08333333333333333,10.483160449547997,5.0,13.0,15.390036138358287,1.966911690648139e-05,Secondary-structure junction hinges,True,assigned_and_evaluated +8711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and juxtamembrane interfaces,False,no_term_above_threshold +8712,87149,24.847504,0.7182617,Amphibian defense peptide,keyword,87162,Antimicrobial,0.64746094,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.811855091969493,0.21751690102769014,0.012405848471422242,,17.533415914982022,0.0,16.0,0.0,1.0,Central toxin interdomain linkers,True,assigned_and_evaluated +8713,82716,19.827194,0.9008789,Laminin,gene3d,82716,Laminin,0.9008789,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,6.0,14.0,124.03814147018029,1.0069410180737423e-11,Glycosylated disulfide-rich ectodomains,True,assigned_too_few_test_positives +8714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WYL N-terminal hydrophobic patch,False,no_term_above_threshold +8715,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta-strand groove motif,False,no_term_above_threshold +8716,36668,19.245771,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9863281,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,ANL AMP-binding N-lobe segment,True,assigned_too_few_test_positives +8717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-basic nucleic-acid binding hotspots,False,no_term_above_threshold +8718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane trafficking helical scaffolds,False,no_term_above_threshold +8719,63951,20.7472,0.9916992,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.87890625,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9988631870304469,0.7207782957782958,0.003987594151528578,1.0,180.75517928573484,18.0,18.0,161.13783783783785,1.0016010608753668e-39,Immunoglobulin-like domain signature,True,assigned_and_evaluated +8720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site adjacent gating segments,False,no_term_above_threshold +8721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal interaction tails,False,no_term_above_threshold +8722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PxP-rich proline–glutamate IDRs,False,no_term_above_threshold +8723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site capping helices,False,no_term_above_threshold +8724,87326,18.894922,0.64208984,Coiled coil,keyword,87326,Coiled coil,0.64208984,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7020476595215389,0.1017085631954156,0.03943287549844927,,2.579283450921944,4.0,16.0,3.1518820046521463,0.055121996922434385,Amphipathic heptad helices,True,assigned_and_evaluated +8725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic cores and interfaces,False,no_term_above_threshold +8726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD C-terminal helical lobe,False,no_term_above_threshold +8727,85762,24.708483,0.9526367,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.94384766,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,18.0,182.7463601532567,5.063691885171866e-35,FAD-binding β–α junction loop,True,assigned_too_few_test_positives +8728,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD/HKD phosphate-handling segments,False,no_term_above_threshold +8729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PCI scaffold C-terminal activation,False,no_term_above_threshold +8730,85672,15.631284,0.6171875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61376953,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6214542998649257,0.03938940790936261,0.01595037660611431,,2.4694970458730947,14.0,14.0,40.01409395973155,9.778128717856954e-23,Amphipathic oligomerization helices,True,assigned_and_evaluated +8731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C beta-loop/tail module,False,no_term_above_threshold +8732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mur ligase C-terminal subdomain,False,no_term_above_threshold +8733,47531,16.331142,0.9370117,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.9370117,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,0.0,19.0,0.0,1.0,Noncatalytic structural alpha helices,True,assigned_too_few_test_positives +8734,52236,18.52991,0.9902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9863281,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,19.0,176.28917800118273,6.371800952949173e-32,Helical repeat PPI surfaces,True,assigned_too_few_test_positives +8735,82029,28.28383,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,TM helix capping residues,True,assigned_too_few_test_positives +8736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/Cache/PAC ligand-pocket β-strands,False,no_term_above_threshold +8737,45714,23.118015,1.0,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",1.0,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,11.0,16.0,204.9471875,5.793739888908718e-24,N-terminal catalytic-core boundary activation,True,assigned_too_few_test_positives +8738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-transfer and docking domains,False,no_term_above_threshold +8739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +8740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/SerThr-rich disordered cytoplasmic tails,False,no_term_above_threshold +8741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-coil boundary detector,False,no_term_above_threshold +8742,61392,16.206049,0.69140625,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.69140625,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.779968253968254,0.14531416045652457,0.0031014621178555605,,46.85343716433942,10.0,14.0,119.62479935794543,1.2798634072523148e-19,Extracellular ligand-binding ectodomain loops,True,assigned_and_evaluated +8743,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular N-glycosylation context sensor,False,no_term_above_threshold +8744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OMP beta-barrel signature,False,no_term_above_threshold +8745,37446,26.418985,0.89208984,F-box domain,interpro,37446,F-box domain,0.89208984,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9253015873015872,0.7167695966290814,0.0031014621178555605,0.8571428571428571,231.10699708454808,14.0,15.0,217.36822916666665,3.2473728197936137e-32,N-terminal PEST-like IDRs,True,assigned_and_evaluated +8746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HAMP-like coiled-coil linkers,False,no_term_above_threshold +8747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-cap boundary residue detector,False,no_term_above_threshold +8748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar Pro/Gly capping motif,False,no_term_above_threshold +8749,46277,24.84465,0.7841797,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.7841797,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.6279041528373674,0.05146119480135873,0.004873726185201595,,10.558901515151515,12.0,16.0,141.05914826498423,2.1904515859345383e-24,RPA/SSB DBD-C zinc finger,True,assigned_and_evaluated +8750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion binding active site segments,False,no_term_above_threshold +8751,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop boundaries,False,no_term_above_threshold +8752,27932,19.571932,0.65771484,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.64208984,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.5361654274329375,0.09337535387740306,0.01949490474080638,0.06818181818181818,4.789731220484062,7.0,19.0,38.13477704678362,7.168994392933424e-10,Broad ribosomal/RNP protein activation,True,assigned_and_evaluated +8753,39958,21.485233,0.8959961,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8959961,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9823782022804679,0.07750191910533467,0.002658396101019052,,29.15363857012339,0.0,20.0,0.0,1.0,Basic C-terminal RNA-binding tails,True,assigned_and_evaluated +8754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved mid-domain hydrophobic motif,False,no_term_above_threshold +8755,46082,18.23367,0.96972656,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.96972656,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9996190476190476,0.8801587301587301,0.0031014621178555605,1.0,283.78832199546486,14.0,14.0,150.93924050632913,9.770395474452712e-31,Regulatory proline/serine-rich disordered linkers,True,assigned_and_evaluated +8756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Paired C-terminal sphingolipid kinase motifs,False,no_term_above_threshold +8757,55054,17.417284,0.95703125,HAD superfamily,interpro,85388,Glutaredoxin,0.8515625,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8762877442273534,0.03769754393069874,0.002215330084182543,,17.01667133031741,0.0,16.0,0.0,1.0,Short glycine-anchored micromotifs,True,assigned_and_evaluated +8758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/α-solenoid scaffolds,False,no_term_above_threshold +8759,38873,15.691454,0.8618164,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.85839844,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.677930728241563,0.04894824566955714,0.002215330084182543,,22.095238095238095,5.0,6.0,142.7705938697318,8.353626270125798e-11,AAA+ pore/coupling loops,True,assigned_and_evaluated +8760,87465,16.014982,0.9140625,Fimbrium,keyword,88058,Signal,0.7807617,47,keywords,Fimbrium,keyword:keywords:Fimbrium,5.0,2257.0,0.875088809946714,0.08825264771745991,0.002215330084182543,,39.83724517966141,0.0,18.0,0.0,1.0,Bacterial Sec signal peptides,True,assigned_and_evaluated +8761,88233,15.716467,0.828125,Viral tail protein,keyword,88233,Viral tail protein,0.828125,46,keywords,Viral tail protein,keyword:keywords:Viral tail protein,,,,,,,,15.0,18.0,388.1575520833333,2.0792719279981986e-37,Trimeric β-solenoid attachment scaffold,True,assigned_too_few_test_positives +8762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemoreceptor signaling coiled-coils,False,no_term_above_threshold +8763,45553,22.493933,0.97558594,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.9399414,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,6.0,16.0,256.98706896551727,1.4468016527079799e-13,Fold-agnostic nuclease catalytic cores,True,assigned_too_few_test_positives +8764,52270,16.78791,0.9477539,"WD40 repeat, conserved site",interpro,88252,WD repeat,0.8989258,43,ip,IPR019775,interpro:ip:IPR019775,,,,,,,,0.0,20.0,0.0,1.0,Periplasmic beta-barrel strand termini,True,assigned_too_few_test_positives +8765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alternating hydrophobic/charged β-strand edge motifs,False,no_term_above_threshold +8766,88161,42.906204,0.69140625,Transmembrane helix,keyword,88161,Transmembrane helix,0.69140625,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7505245803357314,0.5208616148784118,0.1847585290208241,0.4676258992805755,2.8191478771716434,11.0,11.0,5.4274920345926265,1.6633903518332707e-08,Transmembrane ionizable pocket microenvironment,True,assigned_and_evaluated +8767,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GspF/PilC cytoplasmic N-terminal helices,False,no_term_above_threshold +8768,47529,26.150743,0.953125,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.953125,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9809097501115573,0.23617051395470415,0.007089056269384138,0.0625,33.314803124735455,7.0,17.0,31.841535057602808,2.100879457116611e-09,Filamin TPxxxGxY motif,True,assigned_and_evaluated +8769,36914,24.718393,0.98095703,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8105469,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Nucleotide-sugar donor-binding loop,True,assigned_too_few_test_positives +8770,82029,22.31058,0.98876953,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6459961,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,2.0,16.0,23.509858044164037,0.005566517097461136,Transporter pore-lining residues,True,assigned_too_few_test_positives +8771,81799,18.971146,0.9067383,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6381836,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,3.0,10.0,173.6533980582524,1.1503116648969384e-06,AAA+ P-loop NTPase core,True,assigned_too_few_test_positives +8772,29104,17.256277,0.7783203,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.6044922,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane boundary loops and caps,True,assigned_too_few_test_positives +8773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scaffold coiled-coils with low-complexity,False,no_term_above_threshold +8774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory C-terminal helical subdomain,False,no_term_above_threshold +8775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta-strand motif,False,no_term_above_threshold +8776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Singled-out functional TM helix,False,no_term_above_threshold +8777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic terminal regions,False,no_term_above_threshold +8778,81799,20.158285,0.9790039,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7397461,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,5.0,19.0,152.32754215636177,3.325760020019696e-10,AAA+ helical lid subdomain,True,assigned_too_few_test_positives +8779,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved strand-loop edge motifs,False,no_term_above_threshold +8780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helices and boundary motifs,False,no_term_above_threshold +8781,49116,19.414337,0.91748047,Armadillo-type fold,interpro,43624,Homedomain-like superfamily,0.90478516,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9685612788632326,0.042276926290084185,0.002215330084182543,,19.083804527344004,11.0,20.0,47.87087591240876,1.5653550438259488e-16,Alpha-helical interaction surfaces,True,assigned_and_evaluated +8782,49061,17.388672,0.9067383,WD40/YVTN repeat-like-containing domain superfamily,interpro,87413,Disulfide bond,0.64697266,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9024626674357494,0.062118625868559256,0.012405848471422242,,5.007204949476366,0.0,18.0,0.0,1.0,Gly/Pro-rich beta-cap sensor,True,assigned_and_evaluated +8783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization segments,False,no_term_above_threshold +8784,52236,24.430052,0.96777344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.92089844,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,19.0,164.5365661344372,3.7958279824341706e-29,TPR-like helical adaptor scaffolds,True,assigned_too_few_test_positives +8785,36535,20.68761,0.94384766,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9160156,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9967512238540276,0.872987012987013,0.004430660168365086,0.9,197.03316883116884,13.0,13.0,89.79066265060241,1.1174852366600676e-25,Eukaryotic kinase activation loop,True,assigned_and_evaluated +8786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal interaction/assembly modules,False,no_term_above_threshold +8787,87326,33.758133,0.73291016,Coiled coil,keyword,87326,Coiled coil,0.73291016,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7510313445831086,0.2673524965302693,0.03943287549844927,0.2247191011235955,6.779939153582223,18.0,19.0,11.943973912366028,6.647492796621427e-19,Extended amphipathic helical scaffolds,True,assigned_and_evaluated +8788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IlvD conserved internal motifs,False,no_term_above_threshold +8789,36010,17.636908,0.99316406,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9790039,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,5.0,13.0,195.99276791584487,7.220762060289025e-11,Active-site lid helix,True,assigned_too_few_test_positives +8790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zincin pre-HExxH loop,False,no_term_above_threshold +8791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter TM helix-loop hairpins,False,no_term_above_threshold +8792,81685,22.634262,0.96972656,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96533203,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9566629547141796,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,18.0,18.0,85.66235632183908,6.688146947710768e-35,DFG activation loop entry,True,assigned_and_evaluated +8793,15821,16.07804,0.6669922,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6669922,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,20.0,0.0,1.0,WYL/Sm-like β-sheet binding surface,True,assigned_too_few_test_positives +8794,87856,17.377192,0.76660156,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.76660156,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5219669294366467,0.08294828786632065,0.012405848471422242,0.07142857142857142,6.686224489795918,15.0,15.0,84.68892045454545,3.769157467140119e-29,Polymerase thumb-palm clamp,True,assigned_and_evaluated +8795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Uniform full-chain activation,False,no_term_above_threshold +8796,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic helix-caps near active sites,False,no_term_above_threshold +8797,38873,16.078173,0.97753906,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.92871094,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.997069271758437,0.32416666666666666,0.002215330084182543,,146.32883333333334,8.0,14.0,97.89983579638752,8.43466952263264e-15,AAA+ NBD beta-strand hydrophobes,True,assigned_and_evaluated +8798,59211,28.591627,0.9472656,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9472656,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.775905017921147,0.4723350426465181,0.011076650420912717,0.56,42.64240765012765,12.0,13.0,225.55233291298867,7.362752165866068e-28,Glycosyltransferase N-terminal anchor/stem,True,assigned_and_evaluated +8799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-enriched transmembrane helices,False,no_term_above_threshold +8800,27936,17.97322,0.7597656,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.7597656,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,6.0,15.0,256.43440860215054,1.3669546669742073e-13,Acidic/polar caps and sentinels,True,assigned_too_few_test_positives +8801,87489,18.90102,0.61083984,GPI-anchor,keyword,87489,GPI-anchor,0.61083984,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.4948888888888889,0.0031014621178555605,0.0031014621178555605,,1.0,0.0,18.0,0.0,1.0,Transmembrane helix interaction interfaces,True,assigned_and_evaluated +8802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich IDR linkers,False,no_term_above_threshold +8803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted C-terminal amphipathic helix,False,no_term_above_threshold +8804,49116,16.461416,0.72998047,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.72998047,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9959147424511545,0.39166666666666666,0.002215330084182543,0.2,176.79833333333335,10.0,10.0,87.03795620437957,9.682922147562109e-20,Acidic S/T-rich disordered linkers,True,assigned_and_evaluated +8805,47529,16.11772,0.8769531,Immunoglobulin-like fold,interpro,87413,Disulfide bond,0.6298828,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8937137438643462,0.04013422449615131,0.007089056269384138,,5.661434042988344,0.0,17.0,0.0,1.0,Exposed loops/termini CBX-enriched,True,assigned_and_evaluated +8806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Envelope biogenesis surface motifs,False,no_term_above_threshold +8807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-cap and tail,False,no_term_above_threshold +8808,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-binding modules and linkers,False,no_term_above_threshold +8809,50869,15.673143,0.9980469,"DNA binding HTH domain, AraC-type",interpro,88263,Zinc-finger,0.88964844,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,18.0,0.0,1.0,C2H2 beta-strand aromatic anchor,True,assigned_too_few_test_positives +8810,63960,26.914274,0.796875,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.796875,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,18.0,18.0,193.57467532467533,4.1657852190163465e-41,Flavoenzyme catalytic core helix,True,assigned_too_few_test_positives +8811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core aromatic-rich transmembrane helices,False,no_term_above_threshold +8812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop-helix hairpins,False,no_term_above_threshold +8813,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge linker loops,False,no_term_above_threshold +8814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ligand-binding cap motifs,False,no_term_above_threshold +8815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible Gly/Ser loops and linkers,False,no_term_above_threshold +8816,59229,30.899113,0.97753906,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97753906,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9465182359581177,0.7499308563043497,0.0101905183872397,0.7391304347826086,73.59104098603989,18.0,18.0,106.27629233511585,1.4850343564104726e-36,Motif I SAM-binding loop,True,assigned_and_evaluated +8817,87882,38.814342,0.8964844,Palmitate,keyword,87882,Palmitate,0.8964844,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.998963423663557,0.569047619047619,0.002658396101019052,1.0,214.056746031746,15.0,16.0,62.45216480446927,1.980391321520189e-26,Lipoprotein signal peptide cleavage,True,assigned_and_evaluated +8818,52941,16.433226,0.74316406,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.7182617,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,18.0,245.88961669092672,6.9613297944377155e-40,C-terminal TM exit regions,True,assigned_too_few_test_positives +8819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Large extracytoplasmic hydrophilic loops,False,no_term_above_threshold +8820,88072,16.836184,0.9169922,Spliceosome,keyword,88072,Spliceosome,0.9169922,37,keywords,Spliceosome,keyword:keywords:Spliceosome,,,,,,,,9.0,16.0,142.70984042553192,5.4554457542749904e-18,Acidic serine-rich IDR scaffolds,True,assigned_too_few_test_positives +8821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed low-complexity repeats,False,no_term_above_threshold +8822,87681,15.963706,0.69677734,Iron-sulfur,keyword,87681,Iron-sulfur,0.69677734,120,keywords,Iron-sulfur,keyword:keywords:Iron-sulfur,7.0,2257.0,0.7706984126984128,0.044833312983195886,0.0031014621178555605,,14.455541057581874,13.0,14.0,97.81335184250378,1.8937096924844167e-25,Ferredoxin-like Fe–S domains and linkers,True,assigned_and_evaluated +8823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GA-rich low-charge flexible segments,False,no_term_above_threshold +8824,28622,16.085337,0.8300781,transposase activity,go_mf,88164,Transposition,0.7949219,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.8979573712255773,0.6893319549057254,0.002215330084182543,0.6,311.1644444444445,4.0,15.0,305.7487179487179,1.4413471059419646e-09,Pre-core gating linkers,True,assigned_and_evaluated +8825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA substrate-recognition surfaces,False,no_term_above_threshold +8826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-rich structural scaffolds,False,no_term_above_threshold +8827,72011,18.92895,0.96875,"AMP-binding enzyme, C-terminal domain superfamily",interpro,46932,Zinc finger C2H2-type,0.85595703,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Active-site loop/strand segments,True,assigned_too_few_test_positives +8828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oligomeric alpha-helical scaffolds,False,no_term_above_threshold +8829,81685,16.316792,0.8798828,Transferase(Phosphotransferase) domain 1,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8408203,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9288233110616183,0.07762389192888465,0.005316792202038104,,14.599760340291054,0.0,16.0,0.0,1.0,SDR epimerase RDFxxV/T motif,True,assigned_and_evaluated +8830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helix-loop caps,False,no_term_above_threshold +8831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase motor core,False,no_term_above_threshold +8832,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity linkers,False,no_term_above_threshold +8833,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-capping helix,False,no_term_above_threshold +8834,64085,25.480368,0.9628906,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.953125,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9979330897904248,0.7489069306583575,0.012405848471422242,1.0,60.367247946282596,9.0,19.0,55.70320772345063,4.2583931136741773e-14,Repeat domain hinge loops,True,assigned_and_evaluated +8835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrophobic recognition modules,False,no_term_above_threshold +8836,10369,17.197832,0.78808594,DNA integration,go_bp,88163,Transposable element,0.6699219,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,12.0,17.0,386.1046950890448,1.687083516463014e-29,C-terminal catalytic helix/coil,True,assigned_too_few_test_positives +8837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal extension activation,False,no_term_above_threshold +8838,36876,15.603449,1.0,Cytochrome P450,interpro,64154,Cytochrome P450 superfamily,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9999999999999999,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,17.0,389.6797385620915,6.157114732498076e-44,P450 heme-binding Cys pocket,True,assigned_and_evaluated +8839,82029,23.73874,0.99853516,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6230469,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Transmembrane helix hydrophobic packing,True,assigned_too_few_test_positives +8840,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site gripper loops,False,no_term_above_threshold +8841,80926,24.293308,0.86279297,Homeodomain-like,gene3d,80926,Homeodomain-like,0.86279297,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.9473124914301386,0.33267444703770443,0.0057598582188746125,0.5384615384615384,57.757402074161455,0.0,19.0,0.0,1.0,Glycine-rich helix-capping DNA turn,True,assigned_and_evaluated +8842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad inter-domain linker activation,False,no_term_above_threshold +8843,47529,29.2668,0.9916992,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9916992,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9977130745203034,0.701197431954011,0.007089056269384138,0.875,98.91266274501267,16.0,17.0,72.78065156023499,3.195650738846513e-29,Ig/FNIII beta-sandwich modules,True,assigned_and_evaluated +8844,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase catalytic cores,False,no_term_above_threshold +8845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered leaders and linkers,False,no_term_above_threshold +8846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SH3 interaction modules,False,no_term_above_threshold +8847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase cytosolic loop,False,no_term_above_threshold +8848,88160,19.017227,0.8144531,Transmembrane beta strand,keyword,25167,cell outer membrane,0.67285156,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,17.0,18.0,273.3433117583603,1.238197210134836e-40,N-terminal periplasmic linker,True,assigned_too_few_test_positives +8849,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical CAZyme scaffolds,False,no_term_above_threshold +8850,81858,16.198114,0.81689453,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.81689453,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Membrane helix-entry catalytic motifs,True,assigned_too_few_test_positives +8851,85656,15.992895,0.60839844,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.60839844,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.7126984126984127,0.16775865862516914,0.0031014621178555605,,54.090184645286676,17.0,18.0,133.43299104791996,1.9384258312242024e-35,S9 serine hydrolase domain,True,assigned_and_evaluated +8852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory helices and disordered termini,False,no_term_above_threshold +8853,37341,16.907429,0.88916016,WD40 repeat,interpro,87697,Knottin,0.7109375,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9799701046337818,0.22023182247722511,0.011962782454585734,,18.409749012262854,0.0,10.0,0.0,1.0,ABC NBD pre-signature helix,True,assigned_and_evaluated +8854,55053,16.309175,0.87597656,Chloramphenicol acetyltransferase-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.7084961,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,16.0,0.0,1.0,N-terminal nucleophile/cap motif,True,assigned_too_few_test_positives +8855,64058,17.489782,0.9082031,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7705078,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9747149863066047,0.18907811492338672,0.006202924235711121,,30.482093241577417,0.0,12.0,0.0,1.0,Beta-alpha loop nucleotide-binding motifs,True,assigned_and_evaluated +8856,38873,18.671545,0.97558594,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.87939453,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9984902309058615,0.6935897435897436,0.002215330084182543,0.6,313.08641025641026,13.0,13.0,171.32471264367817,2.6588953672088044e-29,ABC NBD H-loop histidine,True,assigned_and_evaluated +8857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory Ser/Thr-rich loops/propeptides,False,no_term_above_threshold +8858,88134,16.1758,0.86816406,Thiol protease,keyword,88134,Thiol protease,0.86816406,93,keywords,Thiol protease,keyword:keywords:Thiol protease,16.0,2257.0,0.9330377063810799,0.7154266445182644,0.007089056269384138,0.8125,100.91987104235768,11.0,17.0,123.64837858220211,2.193422142649995e-21,Ubiquitin/UBL-binding regulatory IDRs,True,assigned_and_evaluated +8859,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cleft recognition loops,False,no_term_above_threshold +8860,55053,15.983958,0.8378906,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.8378906,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,15.0,0.0,1.0,Catalytic transmembrane and juxtamembrane elements,True,assigned_too_few_test_positives +8861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cytosolic sequence motifs,False,no_term_above_threshold +8862,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse mid-chain hydrophobic hotspot,False,no_term_above_threshold +8863,37071,20.119963,0.90478516,Homeodomain,interpro,87566,Homeobox,0.8959961,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,19.0,0.0,1.0,Helices with flanking disorder,True,assigned_too_few_test_positives +8864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TRAM RNA-binding module,False,no_term_above_threshold +8865,85364,17.346066,0.9897461,Periplasmic binding protein-like II,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9628906,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,Hydrophobic helix-end packing,True,assigned_too_few_test_positives +8866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tails and anchors,False,no_term_above_threshold +8867,38873,15.732543,0.69921875,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.61572266,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7964476021314388,0.37171946536700634,0.002215330084182543,0.4,167.79416666666668,8.0,15.0,91.37318007662836,1.7851204770679064e-14,AAA+ C-terminal regulatory lid,True,assigned_and_evaluated +8868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic alpha/beta pocket scaffolds,False,no_term_above_threshold +8869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SBP aromatic helix motif,False,no_term_above_threshold +8870,63831,22.074568,0.82714844,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.82714844,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.6563749444691248,0.09552226406734603,0.002658396101019052,0.16666666666666666,35.932291666666664,16.0,20.0,196.2831275720165,8.446834551509739e-35,Leucine-rich repeat solenoids,True,assigned_and_evaluated +8871,38890,19.195248,0.9975586,HNH nuclease,interpro,88263,Zinc-finger,0.7270508,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,10.0,19.0,682.162471395881,7.760151477335883e-27,Cys-rich loop microdomains,True,assigned_too_few_test_positives +8872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleoporin alpha-solenoid scaffold,False,no_term_above_threshold +8873,85364,24.72373,0.92285156,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.92285156,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,Mature extracytoplasmic exposed segments,True,assigned_too_few_test_positives +8874,87413,17.661602,0.62060547,Disulfide bond,keyword,88058,Signal,0.6176758,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6405889979080115,0.11610455822007426,0.0717766947275144,,1.6175801722389358,6.0,18.0,3.9424056073530385,0.004794363471541561,Cationic processing-site microdomains,True,assigned_and_evaluated +8875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity IDRs,False,no_term_above_threshold +8876,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic mixed structure regulatory connectors,False,no_term_above_threshold +8877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic helical segments,False,no_term_above_threshold +8878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAP/HeH polyanion-binding helices,False,no_term_above_threshold +8879,87811,16.558826,0.92089844,Motor protein,keyword,58239,P-loop containing nucleoside triphosphate hydrolase,0.7651367,30,keywords,Motor protein,keyword:keywords:Motor protein,,,,,,,,0.0,14.0,0.0,1.0,Phosphate sensing loop-helix module,True,assigned_too_few_test_positives +8880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory N-terminal helix–loop–β,False,no_term_above_threshold +8881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed beta-hairpin motif,False,no_term_above_threshold +8882,85364,27.383375,0.8652344,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8652344,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,PBP domain alpha helices,True,assigned_too_few_test_positives +8883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal scaffolds and TM anchors,False,no_term_above_threshold +8884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Broad activation, C-terminal helix peaks",False,no_term_above_threshold +8885,58239,19.55408,0.61621094,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.61621094,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6564839873703202,0.2815285056342013,0.017722640673460344,0.3,15.885245930409809,18.0,19.0,33.964553596860455,5.74704533271255e-27,Coiled-coil globular head domains,True,assigned_and_evaluated +8886,81685,25.300737,0.98583984,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.89208984,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9996288047512992,0.9621212121212123,0.005316792202038104,1.0,180.95896464646466,11.0,11.0,85.66235632183908,1.3744904994636893e-21,Conserved kinase core scaffold,True,assigned_and_evaluated +8887,46277,21.212925,0.7246094,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.7246094,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.67495750020238,0.15072050973690315,0.004873726185201595,0.2727272727272727,30.92510822510822,0.0,15.0,0.0,1.0,Netrin-like polyanion-binding loops,True,assigned_and_evaluated +8888,86130,15.759979,0.66259766,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,81289,lambda repressor-like DNA-binding domains,0.6201172,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.7097777777777778,0.05805881377494837,0.0031014621178555605,,18.719820384294067,0.0,19.0,0.0,1.0,Non-catalytic flanking helices,True,assigned_and_evaluated +8889,84753,32.3974,0.88427734,3.30.420.40,gene3d,84753,3.30.420.40,0.88427734,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,15.0,15.0,414.03472222222223,2.059324768069639e-39,Actin/Hsp70 N-terminal phosphate loop,True,assigned_too_few_test_positives +8890,64620,16.482174,0.98095703,Histidine kinase/HSP90-like ATPase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6870117,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,HATPase_c C-terminal beta-strand,True,assigned_too_few_test_positives +8891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospholipase mid-domain and TM peaks,False,no_term_above_threshold +8892,46082,16.773054,0.9873047,PH-like domain superfamily,interpro,87697,Knottin,0.6977539,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9992380952380953,0.8922902494331064,0.0031014621178555605,0.8571428571428571,287.69987042436014,16.0,19.0,127.10672884743504,4.140754089769689e-32,PH domain PIP-binding surface,True,assigned_and_evaluated +8893,45290,15.938438,0.8178711,Protein kinase-like domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7597656,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.8069210201563143,0.058520642693342284,0.0057598582188746125,,10.160083889144119,0.0,18.0,0.0,1.0,Active-site adjacent catalytic micro-motif,True,assigned_and_evaluated +8894,36535,21.453203,0.89501953,Protein kinase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6977539,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9451490876724521,0.3268891199628905,0.004430660168365086,0.7,73.77887437562438,0.0,12.0,0.0,1.0,ABC transporter NBD motifs,True,assigned_and_evaluated +8895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TRUD-wide early beta-strand signature,False,no_term_above_threshold +8896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Strand/helix-to-loop junctions,False,no_term_above_threshold +8897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic GH scaffold regions,False,no_term_above_threshold +8898,85656,21.035559,0.78222656,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.7817383,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9184444444444444,0.388414618274103,0.0031014621178555605,0.2857142857142857,125.23597049209293,14.0,14.0,141.281990521327,2.4550488164569493e-30,Serine hydrolase nucleophile elbow,True,assigned_and_evaluated +8899,81858,15.559586,0.98583984,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7167969,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,17.0,17.0,261.4956140350877,4.358104152891723e-41,GPCR 7TM hydrophobic signature,True,assigned_too_few_test_positives +8900,36354,20.83431,0.87060547,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.8359375,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,11.0,11.0,214.4640287769784,5.826731801329522e-26,RGG/RS-rich disordered RNA tails,True,assigned_too_few_test_positives +8901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular non-catalytic motif activation,False,no_term_above_threshold +8902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Contiguous surface interface patches,False,no_term_above_threshold +8903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ca2+-binding regulatory helix-loop,False,no_term_above_threshold +8904,36535,19.694029,0.92578125,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8979492,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9269470404984423,0.14533714034597348,0.004430660168365086,,32.80259257608621,0.0,8.0,0.0,1.0,ABC NBD switch loops,True,assigned_and_evaluated +8905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-sandwich interaction loops,False,no_term_above_threshold +8906,30398,16.20477,0.6508789,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6171875,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.5393831457945438,0.019582175319880237,0.004873726185201595,,4.017906336088155,18.0,20.0,64.8054347826087,2.3294535363803967e-31,RecA-like ATPase C-terminal lid,True,assigned_and_evaluated +8907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly and targeting headpieces,False,no_term_above_threshold +8908,85664,23.6877,0.97021484,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.97021484,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Amphipathic interfacial docking helix,True,assigned_too_few_test_positives +8909,30398,18.977962,0.70751953,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.6123047,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6741277422488465,0.28491964393603736,0.004873726185201595,0.2727272727272727,58.4603305785124,12.0,12.0,72.00603864734299,1.3232849389198435e-22,ABC NBD H-loop N-cap,True,assigned_and_evaluated +8910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aliphatic-rich disordered LCRs,False,no_term_above_threshold +8911,84152,29.026394,0.96972656,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.96972656,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,C-terminal active-site flanks,True,assigned_too_few_test_positives +8912,85364,23.049068,0.7807617,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7807617,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,18.0,284.3874859708193,6.285282157931668e-41,Binding-site helix-loop hinges,True,assigned_too_few_test_positives +8913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SMC/Rad50 coiled-coil stalk,False,no_term_above_threshold +8914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered linkers,False,no_term_above_threshold +8915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic nucleic-acid interfaces,False,no_term_above_threshold +8916,31094,15.872172,0.94873047,phosphopantetheine binding,go_mf,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.91796875,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9925678682688028,0.2550081783063091,0.004430660168365086,,57.555345843733974,0.0,13.0,0.0,1.0,Early β-edge rim motif,True,assigned_and_evaluated +8917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter C-terminal TM helices,False,no_term_above_threshold +8918,85364,21.672134,0.7895508,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7895508,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,16.0,20.0,240.89292929292932,3.186284787002184e-36,Aromatic substrate-recognition loops,True,assigned_too_few_test_positives +8919,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear RNP polyampholyte IDRs,False,no_term_above_threshold +8920,87892,17.67554,0.80371094,Periplasm,keyword,88058,Signal,0.7529297,115,keywords,Periplasm,keyword:keywords:Periplasm,,,,,,,,13.0,18.0,83.28744895766171,3.1586201561165535e-23,Mid-chain periplasmic core activation,True,assigned_too_few_test_positives +8921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ESX-biased Actinobacterial accessory regions,False,no_term_above_threshold +8922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic strand to helix transitions,False,no_term_above_threshold +8923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical polymer-binding interfaces,False,no_term_above_threshold +8924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic serine threonine phospho IDRs,False,no_term_above_threshold +8925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short surface interaction loops,False,no_term_above_threshold +8926,47717,16.462242,0.89404297,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6074219,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,12.0,12.0,273.49082568807336,1.5561062230572482e-29,Helicase RecA2 domain boundary,True,assigned_too_few_test_positives +8927,63951,16.33582,0.8232422,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.73828125,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.7684361407671016,0.12261285387345308,0.003987594151528578,,30.748579021375956,0.0,15.0,0.0,1.0,Glycosylated extracellular ectodomain loops,True,assigned_and_evaluated +8928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered linkers,False,no_term_above_threshold +8929,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory tails and boundary patches,False,no_term_above_threshold +8930,46581,19.070705,0.74902344,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.74902344,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,6.0,16.0,64.99382267441861,5.611857745891967e-10,Glycine/charged interaction patches,True,assigned_too_few_test_positives +8931,36104,21.079704,0.91796875,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.91796875,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Soluble helical/coiled-coil marker,True,assigned_too_few_test_positives +8932,52236,18.787506,0.9916992,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9868164,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,11.0,18.0,136.46088223054517,9.946520512367457e-22,TPR alpha-solenoid PPI scaffolds,True,assigned_too_few_test_positives +8933,64507,36.101437,0.9941406,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9941406,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997034400948992,0.9328843995510663,0.003987594151528578,1.0,233.94667664297296,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin repeat start signature,True,assigned_and_evaluated +8934,87384,15.864645,0.6376953,DNA-binding,keyword,87384,DNA-binding,0.6376953,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.5461917600471817,0.046954760346055543,0.043863535666814356,,1.0704736777883572,2.0,18.0,1.3611168184827522,0.6829295766049691,Weak polar low-complexity signature,True,assigned_and_evaluated +8935,38317,25.870167,0.99316406,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.99316406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9798730158730158,0.07562477951240552,0.0031014621178555605,,24.38358962278561,0.0,18.0,0.0,1.0,HK/ABC helical transmission elements,True,assigned_and_evaluated +8936,64155,20.930014,0.80810547,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.77001953,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,12.0,15.0,221.84558139534883,5.20313982495647e-27,RNase H-like HLH substrate-binding motif,True,assigned_too_few_test_positives +8937,30398,15.99238,0.74560547,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.66308594,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6570266332065086,0.1939804755775142,0.004873726185201595,0.18181818181818182,39.80126667076814,10.0,10.0,72.00603864734299,6.39947883854114e-19,ABC NBD signature motif,True,assigned_and_evaluated +8938,30107,17.054552,0.80126953,nickel cation binding,go_mf,30107,nickel cation binding,0.80126953,31,go,GO:0016151,go_mf:go:GO:0016151,20.0,2257.0,0.974675905230219,0.9504430660168368,0.008861320336730172,0.95,107.25750000000004,3.0,16.0,111.789375,4.7948874281978705e-06,FDTS motif/insert signature,True,assigned_and_evaluated +8939,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory tail,False,no_term_above_threshold +8940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small/polar low-complexity regions,False,no_term_above_threshold +8941,61392,24.26254,0.9995117,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.6870117,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,167.4747191011236,5.14338702087321e-40,LRR core hydrophobic position,True,assigned_and_evaluated +8942,49116,22.734758,0.8925781,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8925781,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9936056838365896,0.1842528735632184,0.002215330084182543,,83.17174712643678,15.0,20.0,65.27846715328467,3.0792553979016777e-25,N-terminal noncatalytic activation,True,assigned_and_evaluated +8943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and coiled-coils,False,no_term_above_threshold +8944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered basic C-terminal tails,False,no_term_above_threshold +8945,87914,17.200743,0.66552734,Phosphoprotein,keyword,24917,nucleus,0.6591797,957,keywords,Phosphoprotein,keyword:keywords:Phosphoprotein,84.0,2257.0,0.7644248679683563,0.14209000666754615,0.03721754541426672,0.011904761904761904,3.8178231553410913,12.0,20.0,3.6558610117526826,2.409089765892504e-05,Proline-directed S/T-rich IDRs,True,assigned_and_evaluated +8946,38317,23.253994,1.0,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7763672,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9993015873015874,0.834065934065934,0.0031014621178555605,1.0,268.92668759811613,18.0,18.0,384.6516129032258,3.0395884794908227e-46,N-terminal targeting IDRs,True,assigned_and_evaluated +8947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH/HDH N-terminal Rossmann subdomain,False,no_term_above_threshold +8948,37894,17.05085,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8886719,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,13.0,709.7738095238095,2.0554498274794366e-37,SDR NAD(P)H-binding loop,True,assigned_too_few_test_positives +8949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Receptor ectodomains, luminal loops, TIR",False,no_term_above_threshold +8950,87149,16.141098,0.6850586,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6850586,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.509637569698135,0.011887847785834151,0.012405848471422242,,0.9582454447367028,0.0,14.0,0.0,1.0,Alpha-helical packing context,True,assigned_and_evaluated +8951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site/interface gating loops,False,no_term_above_threshold +8952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane hairpin boundary signatures,False,no_term_above_threshold +8953,45553,22.646454,0.9770508,Restriction endonuclease type II-like,interpro,45553,Restriction endonuclease type II-like,0.9770508,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,4.0,14.0,195.79967159277504,8.50565017414908e-09,Mg2+-dependent nuclease active site,True,assigned_too_few_test_positives +8954,88160,19.36424,0.8076172,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7114258,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,16.0,235.15564320388347,1.4007539360355413e-29,Outer membrane beta-barrels,True,assigned_too_few_test_positives +8955,87413,26.070057,0.6152344,Disulfide bond,keyword,87413,Disulfide bond,0.6152344,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5649916025811014,0.1334592431793097,0.0717766947275144,0.05555555555555555,1.859367357133963,11.0,13.0,10.00764500328079,2.1779506549767624e-10,Compact extracellular recognition modules,True,assigned_and_evaluated +8956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic/basic histidine-flanking hotspot,False,no_term_above_threshold +8957,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Endosomal PX proteins and GAPs,False,no_term_above_threshold +8958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix–loop–helix hairpins,False,no_term_above_threshold +8959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long compositionally biased IDRs,False,no_term_above_threshold +8960,38873,17.641403,0.70947266,AAA+ ATPase domain,interpro,38873,AAA+ ATPase domain,0.70947266,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.6970248667850798,0.2584720551933667,0.002215330084182543,0.2,116.67428571428573,7.0,8.0,149.9091235632184,4.052542553900822e-15,P-loop NTPase coupling loops,True,assigned_and_evaluated +8961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich low-complexity IDRs,False,no_term_above_threshold +8962,50806,19.29187,0.99853516,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9770508,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,18.0,0.0,1.0,HTH DNA recognition helix,True,assigned_too_few_test_positives +8963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic POTRA-like interaction domains,False,no_term_above_threshold +8964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand capping motifs,False,no_term_above_threshold +8965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar C-terminal periplasmic tail,False,no_term_above_threshold +8966,39971,25.641226,1.0,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,14.0,16.0,579.6486111111111,8.730560303383576e-38,Binuclear metallophosphoesterase catalytic core,True,assigned_too_few_test_positives +8967,47531,15.602562,0.74853516,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.74853516,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,13.0,14.0,234.5862590799032,2.2574422526431795e-30,Nucleotide-metabolism alpha/beta cores,True,assigned_too_few_test_positives +8968,36535,17.282389,0.9790039,Protein kinase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.71972656,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9967734757454383,0.5744774815827447,0.004430660168365086,0.9,129.6595675932255,0.0,11.0,0.0,1.0,ABC NBD N-terminal boundary,True,assigned_and_evaluated +8969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycan-binding catalytic cleft,False,no_term_above_threshold +8970,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral charged recognition patches,False,no_term_above_threshold +8971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helices with charged disorder,False,no_term_above_threshold +8972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MAT C-terminal LITPxRPMSM motif,False,no_term_above_threshold +8973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical coiled-coil stalks,False,no_term_above_threshold +8974,47529,17.452976,0.8852539,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8852539,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9368446006247212,0.054132853732370464,0.007089056269384138,,7.636115679622509,2.0,19.0,8.13994129292102,0.04133969154815049,Short hydrophobic beta-strand edges,True,assigned_and_evaluated +8975,87326,25.603708,0.6958008,Coiled coil,keyword,87326,Coiled coil,0.6958008,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7485177660765372,0.1487693483004407,0.03943287549844927,,3.7727238102707266,2.0,20.0,1.2607528018608587,0.7440908903413428,Helical coiled-coil interaction surfaces,True,assigned_and_evaluated +8976,37097,18.91715,0.84716797,Cro/C1-type helix-turn-helix domain,interpro,37097,Cro/C1-type helix-turn-helix domain,0.84716797,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,11.0,17.0,363.94617092119864,1.2886087431085069e-26,Domain-adjacent charged regulatory linkers,True,assigned_too_few_test_positives +8977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane and low-complexity helices,False,no_term_above_threshold +8978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type IIA GyrA/ParC catalytic core,False,no_term_above_threshold +8979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered regulatory heads,False,no_term_above_threshold +8980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity charged segments,False,no_term_above_threshold +8981,82029,25.738707,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,MFS TM helix glycine hotspots,True,assigned_too_few_test_positives +8982,87697,21.683628,0.90478516,Knottin,keyword,88009,Repeat,0.7138672,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9541166678227092,0.1489975881459243,0.017279574656623838,,8.622757857573106,0.0,18.0,0.0,1.0,Conserved anchors in repeats,True,assigned_and_evaluated +8983,64026,19.792591,0.78125,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.78125,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.73500666370502,0.3413291980505095,0.002658396101019052,0.3333333333333333,128.39666666666665,4.0,19.0,35.65849282296651,8.143603685973816e-06,10-12 TM eukaryotic transporter core,True,assigned_and_evaluated +8984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfotransferase PAPS binding core,False,no_term_above_threshold +8985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NAD-modifying and nuclease domains,False,no_term_above_threshold +8986,38873,17.767462,0.80566406,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6147461,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8980905861456484,0.6004430660168365,0.002215330084182543,0.8,271.04,9.0,9.0,171.32471264367817,1.8650004750458193e-20,ABC NBD signature helix,True,assigned_and_evaluated +8987,88178,16.096516,0.69628906,Ubiquinone,keyword,88178,Ubiquinone,0.69628906,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,7.0,12.0,294.73658192090403,1.8729107743557608e-16,C-terminal TM-juxtamembrane regions,True,assigned_too_few_test_positives +8988,27932,18.502623,0.6230469,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.6064453,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.7352832436429364,0.15681178714267477,0.01949490474080638,0.06818181818181818,8.043731899568568,5.0,14.0,36.96738591269841,3.019550272135683e-07,"Near-global RnpA activation, C-terminal hotspot",True,assigned_and_evaluated +8989,82029,23.652637,0.9921875,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.62353516,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS TM1/TM7 helix motifs,True,assigned_too_few_test_positives +8990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SNARE-like extended amphipathic helices,False,no_term_above_threshold +8991,59224,25.23432,0.8334961,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.8334961,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.841873015873016,0.1472594181902409,0.0031014621178555605,,47.48064383648196,0.0,15.0,0.0,1.0,PTP general-acid helix-loop,True,assigned_and_evaluated +8992,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short aromatic Tyr/Phe motifs,False,no_term_above_threshold +8993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic oligomerization helices,False,no_term_above_threshold +8994,24907,18.137735,0.70654297,extracellular space,go_cc,88058,Signal,0.62841797,241,go,GO:0005615,go_cc:go:GO:0005615,18.0,2257.0,0.6959207979752866,0.08434359424144589,0.007975188303057155,,10.575749566830188,6.0,13.0,17.187623120165284,1.048993231526846e-06,Mature secreted ectodomains,True,assigned_and_evaluated +8995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sandwich core beta-strands,False,no_term_above_threshold +8996,61392,22.348032,0.9941406,Leucine-rich repeat domain superfamily,interpro,49230,Acyl-CoA N-acyltransferase,0.9238281,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.996,0.28746665332799787,0.0031014621178555605,,92.68746236589874,0.0,16.0,0.0,1.0,PbH1 beta-solenoid hydrophobic core,True,assigned_and_evaluated +8997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATPase-flanking acidic helices and linkers,False,no_term_above_threshold +8998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA-like helicase ATPase core,False,no_term_above_threshold +8999,81685,16.725529,0.83447266,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.7685547,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.8115441722345953,0.06607824489993752,0.005316792202038104,,12.428216561596582,0.0,16.0,0.0,1.0,Lipid-linked glycan transferases,True,assigned_and_evaluated +9000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glutamate-biased acidic tract detector,False,no_term_above_threshold +9001,4066,18.67213,0.7416992,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.7416992,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.5939609236234458,0.0684389307340127,0.002215330084182543,,30.893333333333338,0.0,19.0,0.0,1.0,Aromatic-hydrophobic core motifs,True,assigned_and_evaluated +9002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GTPase G-domain acidic motif,False,no_term_above_threshold +9003,82029,33.407337,0.9951172,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Juxtamembrane helix-entry anchor motif,True,assigned_too_few_test_positives +9004,69093,16.21005,0.91064453,"ANL, N-terminal domain",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.80810547,40,ip,IPR042099,interpro:ip:IPR042099,,,,,,,,0.0,16.0,0.0,1.0,DHp H-box K/R–T–(P) motif,True,assigned_too_few_test_positives +9005,88058,16.079786,0.60009766,Signal,keyword,88058,Signal,0.60009766,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.567980099690892,0.1020579855454809,0.09127159946832078,,1.1181789969716038,0.0,20.0,0.0,1.0,Unknown generic feature,True,assigned_and_evaluated +9006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transglutaminase catalytic core helix,False,no_term_above_threshold +9007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil stalks and hinges,False,no_term_above_threshold +9008,69990,16.334703,0.94921875,DNA/RNA polymerase superfamily,interpro,87856,Nucleotidyltransferase,0.7758789,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.8422222222222223,0.40412554798495337,0.0031014621178555605,0.42857142857142855,130.3016231145771,12.0,15.0,210.11806167400883,1.0036457582199667e-26,Polymerase palm DxD motif,True,assigned_and_evaluated +9009,48241,16.74166,0.8017578,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.8017578,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,7.0,19.0,142.633971291866,7.486865741454527e-14,HTH effector-binding core,True,assigned_too_few_test_positives +9010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic ligand-binding sensor,False,no_term_above_threshold +9011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal GluRS anticodon-binding subdomain,False,no_term_above_threshold +9012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/charged low-complexity patches,False,no_term_above_threshold +9013,87852,15.778267,0.70996094,Nucleosome core,keyword,87852,Nucleosome core,0.70996094,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,19.0,0.0,1.0,Disordered low-complexity repeats,True,assigned_too_few_test_positives +9014,50869,25.656097,0.9995117,"DNA binding HTH domain, AraC-type",interpro,88263,Zinc-finger,0.7919922,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,17.0,0.0,1.0,C2H2 helix His2+1 site,True,assigned_too_few_test_positives +9015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like N-terminal glycine loop,False,no_term_above_threshold +9016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved M3 mid-domain activation,False,no_term_above_threshold +9017,36115,22.143929,0.7949219,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7895508,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,16.0,0.0,1.0,PAS/HAMP sensory modules,True,assigned_too_few_test_positives +9018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteolytic boundary activation switches,False,no_term_above_threshold +9019,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface beta-loop binding hotspot,False,no_term_above_threshold +9020,36091,18.311348,0.99902344,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9819336,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,19.0,19.0,377.3481012658228,1.8275710853354973e-48,Hydrophobic GNAT active-site beta-strand,True,assigned_too_few_test_positives +9021,37894,22.8368,0.9790039,Short-chain dehydrogenase/reductase SDR,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8364258,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR NAD(P)-binding loop residue,True,assigned_too_few_test_positives +9022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Start-of-domain marker,False,no_term_above_threshold +9023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short conserved functional motifs,False,no_term_above_threshold +9024,55054,21.762651,0.90527344,HAD superfamily,interpro,55054,HAD superfamily,0.90527344,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.7938721136767318,0.12088613203367303,0.002215330084182543,,54.56800000000001,0.0,13.0,0.0,1.0,Catalytic nucleotide-donor binding loop,True,assigned_and_evaluated +9025,47717,19.485237,0.8911133,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.8911133,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,13.0,13.0,273.49082568807336,6.20501063887732e-32,Helicase flanking regulatory linkers,True,assigned_too_few_test_positives +9026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cytosolic regulatory regions,False,no_term_above_threshold +9027,38873,18.979244,0.9199219,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8696289,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.891474245115453,0.42147481204858256,0.002215330084182543,0.4,190.25373015873018,11.0,18.0,104.69843550447,1.8507498292021915e-20,LGxANLRVR helical motif,True,assigned_and_evaluated +9028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal catalytic activation,False,no_term_above_threshold +9029,34103,17.297794,0.87402344,ubiquitin protein ligase activity,go_mf,46929,"Zinc finger, RING/FYVE/PHD-type",0.8261719,78,go,GO:0061630,go_mf:go:GO:0061630,,,,,,,,16.0,16.0,115.54457364341084,3.592451221393267e-33,Non-catalytic E3 localization/recognition domains,True,assigned_too_few_test_positives +9030,87276,17.254133,0.62060547,Cell membrane,keyword,25079,plasma membrane,0.6176758,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7919558058891056,0.40346747475192396,0.11120957022596367,0.5737051792828686,3.6279923924904076,1.0,14.0,0.5861055404820887,1.0,Alpha-helical hydrophobic micro-motif,True,assigned_and_evaluated +9031,47717,17.971848,0.9975586,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7675781,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,16.0,17.0,257.4031300593632,6.636301916524782e-38,Walker A P-loop motif,True,assigned_too_few_test_positives +9032,49045,16.161722,0.9916992,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9819336,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,13.0,17.0,414.47754010695184,1.4239364698570598e-32,β-rich catalytic core detector,True,assigned_too_few_test_positives +9033,8138,37.654175,0.91308594,translation,go_bp,88022,Ribosomal protein,0.86621094,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.9856861407061724,0.8374982954140828,0.018165706690296855,0.975609756097561,46.103259823160606,8.0,8.0,103.15051903114187,1.7865204112757912e-16,LSU tunnel/PTC interactors,True,assigned_and_evaluated +9034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH C-terminal oligomerization subdomain,False,no_term_above_threshold +9035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His/Met-rich metal-binding segments,False,no_term_above_threshold +9036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic C-terminal tails,False,no_term_above_threshold +9037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal cytoplasmic and first TM,False,no_term_above_threshold +9038,59229,18.805431,0.9091797,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7446289,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9416332567825308,0.21275044365096996,0.0101905183872397,,20.87729353566257,1.0,14.0,7.591163738222561,0.19891529922107729,Conserved YjeF_N motif patch,True,assigned_and_evaluated +9039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GIY-YIG-like beta-alpha phosphate-binding core,False,no_term_above_threshold +9040,45324,15.880843,0.9091797,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9091797,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9999999999999999,1.0,0.002215330084182543,1.0,451.40000000000003,6.0,20.0,164.09449541284403,2.702626978251405e-12,Post-signal N-terminal transition segments,True,assigned_and_evaluated +9041,85664,17.04139,0.9375,Glycogen Phosphorylase B;,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.8261719,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,11.0,0.0,1.0,Beta-strand start N-cap signature,True,assigned_too_few_test_positives +9042,36449,20.07207,0.9980469,EamA domain,interpro,36449,EamA domain,0.9980469,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,17.0,0.0,1.0,TIR/SEFIR BB-loop hotspot,True,assigned_too_few_test_positives +9043,38873,18.530016,0.98535156,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9692383,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9968472468916519,0.36699300699300696,0.002215330084182543,0.4,165.66064335664336,13.0,15.0,148.48141762452107,2.4988105602165728e-27,RecA-like P-loop beta N-caps,True,assigned_and_evaluated +9044,43624,15.882691,0.8198242,Homedomain-like superfamily,interpro,87384,DNA-binding,0.7182617,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.6661646586345381,0.011377699175765118,0.007089056269384138,,1.6049666899813668,10.0,19.0,46.21424695760018,6.753618066088916e-15,General helical structural elements,True,assigned_and_evaluated +9045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic acidic interaction patches,False,no_term_above_threshold +9046,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic beta-strand loop motif,False,no_term_above_threshold +9047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP beta-lactamase pocket loops,False,no_term_above_threshold +9048,85672,26.361488,0.78027344,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7636719,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7103782080144079,0.09133717759912474,0.01595037660611431,,5.726333606700682,0.0,16.0,0.0,1.0,HExxH catalytic glutamate,True,assigned_and_evaluated +9049,50338,21.472157,0.9589844,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.9589844,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,DHp/HPt post-His helix,True,assigned_too_few_test_positives +9050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic scaffold alpha helices,False,no_term_above_threshold +9051,45288,16.03223,0.9995117,CheY-like superfamily,interpro,85664,Glycogen Phosphorylase B;,0.9013672,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,17.0,19.0,413.52794777641776,4.225511880631101e-43,REC output docking surface,True,assigned_too_few_test_positives +9052,64475,17.650284,0.9848633,ACP-like superfamily,interpro,50806,"Homeobox, conserved site",0.9003906,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9941724941724942,0.32328304360076937,0.0057598582188746125,,56.12690995437973,0.0,19.0,0.0,1.0,HTH-adjacent amphipathic helix motif,True,assigned_and_evaluated +9053,87852,17.681896,0.9082031,Nucleosome core,keyword,24789,nucleosome,0.87158203,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,18.0,0.0,1.0,Disordered low-complexity tandem repeats,True,assigned_too_few_test_positives +9054,37312,15.688559,1.0,"DNA-binding HTH domain, TetR-type",interpro,43624,Homedomain-like superfamily,0.75390625,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,18.0,19.0,818.5949656750571,4.3313349653425253e-51,HTH supporting helix,True,assigned_too_few_test_positives +9055,87276,24.746902,0.6098633,Cell membrane,keyword,88161,Transmembrane helix,0.60302734,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6673386215854429,0.27704883870009334,0.11120957022596367,0.3665338645418327,2.49123198783311,14.0,17.0,6.757452113793494,1.5756407874136805e-10,Structured extracytoplasmic luminal domains,True,assigned_and_evaluated +9056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-NB-ARC helical linker,False,no_term_above_threshold +9057,38317,23.322823,0.9526367,Pentatricopeptide repeat,interpro,63831,F-box-like domain superfamily,0.88671875,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.993015873015873,0.2891369929340163,0.0031014621178555605,0.2857142857142857,93.22602757886783,0.0,18.0,0.0,1.0,LRR/solenoid recognition scaffolds,True,assigned_and_evaluated +9058,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP active-site entrance loop,False,no_term_above_threshold +9059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small multi-pass membrane proteins,False,no_term_above_threshold +9060,47529,19.004925,0.7182617,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7182617,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7709867246764837,0.17916150663308875,0.007089056269384138,0.125,25.27297002943008,3.0,18.0,12.88824038045828,0.0026528961134651414,Extracytoplasmic glycan and copper systems,True,assigned_and_evaluated +9061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic POTRA-like interaction modules,False,no_term_above_threshold +9062,88006,16.72377,0.71777344,Receptor,keyword,88161,Transmembrane helix,0.63378906,160,keywords,Receptor,keyword:keywords:Receptor,10.0,2257.0,0.618758344459279,0.019101947201532493,0.004430660168365086,,4.311309483385884,10.0,16.0,36.10767926356589,3.8709579876673916e-14,Single-pass signal-anchor helix,True,assigned_and_evaluated +9063,47717,18.072235,0.99902344,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.67871094,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,11.0,11.0,273.49082568807336,3.968136987320571e-27,RecA-like coupling helices,True,assigned_too_few_test_positives +9064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha helices,False,no_term_above_threshold +9065,25169,18.8247,0.85498047,pilus,go_cc,25169,pilus,0.85498047,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8931616341030196,0.2026147831885537,0.002215330084182543,,91.46031313131314,0.0,16.0,0.0,1.0,Conserved core complexes and enzymes,True,assigned_and_evaluated +9066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-capped anticodon-binding helices,False,no_term_above_threshold +9067,46082,15.783936,0.87841797,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.87841797,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.8741269841269842,0.02409037901900105,0.0031014621178555605,,7.767426492269339,0.0,20.0,0.0,1.0,Conserved central helical motif,True,assigned_and_evaluated +9068,87697,20.953773,0.9248047,Knottin,keyword,87413,Disulfide bond,0.8334961,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9787056946660193,0.28250324470462823,0.017279574656623838,,16.348969828162716,0.0,17.0,0.0,1.0,Disulfide-rich extracellular repeats,True,assigned_and_evaluated +9069,64148,36.272594,0.91308594,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.88916016,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9633719016038755,0.43054236331005497,0.008418254319893664,0.21052631578947367,51.14390073635759,12.0,20.0,53.391940298507464,1.0698564008153224e-18,Pre-recognition helix-loop wedge,True,assigned_and_evaluated +9070,55054,15.718139,0.95751953,HAD superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8017578,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8817051509769094,0.05730814955770665,0.002215330084182543,,25.868898710348784,0.0,14.0,0.0,1.0,SecA LNAK central motif,True,assigned_and_evaluated +9071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +9072,64003,23.60803,0.98828125,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.80322266,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,20.0,20.0,130.4617067833698,3.714698100161221e-42,C2H2 inter-finger linker motif,True,assigned_and_evaluated +9073,37020,16.695498,0.99609375,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98876953,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,11.0,15.0,598.9324200913242,2.0976927243696306e-29,Catalytic beta-strand in glycosyltransferases,True,assigned_too_few_test_positives +9074,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic interhelical metal-binding loops,False,no_term_above_threshold +9075,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBM-like glycan-binding tails,False,no_term_above_threshold +9076,85664,15.804112,0.76171875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.76171875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,Histidine kinase ATP-lid residue,True,assigned_too_few_test_positives +9077,37640,21.9642,0.9238281,EF-hand domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7910156,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,9.0,0.0,1.0,ABC NBD signature-adjacent helix,True,assigned_too_few_test_positives +9078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal Pro–aromatic–Gly motif,False,no_term_above_threshold +9079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small PPI adaptor/scaffold detector,False,no_term_above_threshold +9080,45551,15.63597,0.92578125,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.92578125,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,20.0,0.0,1.0,NAD/ADPr-binding loop,True,assigned_too_few_test_positives +9081,45804,25.13341,0.98339844,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.95996094,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,18.0,18.0,276.02314814814815,9.166178856014388e-44,Intracellular TM helix-loop junction,True,assigned_too_few_test_positives +9082,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular low-complexity metal-binding regions,False,no_term_above_threshold +9083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed glycine-rich loops,False,no_term_above_threshold +9084,88152,15.8484745,0.6894531,Transducer,keyword,88152,Transducer,0.6894531,76,keywords,Transducer,keyword:keywords:Transducer,,,,,,,,12.0,13.0,144.07007652033832,1.606239082366345e-25,GPCR 7TM helical core,True,assigned_too_few_test_positives +9085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP aminotransferase beta strand motif,False,no_term_above_threshold +9086,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand/coil boundary loops,False,no_term_above_threshold +9087,87317,15.762832,0.74560547,Cleavage on pair of basic residues,keyword,88058,Signal,0.69628906,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.8495649263721553,0.08820044989845587,0.007089056269384138,,12.44177596380093,0.0,19.0,0.0,1.0,SRP/Sec and lipoprotein signal peptides,True,assigned_and_evaluated +9088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-boundary/hinge glycine marker,False,no_term_above_threshold +9089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible helix-cap loops and linkers,False,no_term_above_threshold +9090,33780,18.726225,0.77197266,"4 iron, 4 sulfur cluster binding",go_mf,87681,Iron-sulfur,0.76123047,94,go,GO:0051539,go_mf:go:GO:0051539,,,,,,,,11.0,13.0,121.85637309550353,3.363580311098055e-22,Fe-S electron-transfer cores,True,assigned_too_few_test_positives +9091,87697,21.022554,0.88720703,Knottin,keyword,87697,Knottin,0.88720703,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9239208342003653,0.1017123238606794,0.017279574656623838,,5.886274742398805,0.0,19.0,0.0,1.0,Conserved structural junction pivots,True,assigned_and_evaluated +9092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted low-complexity disordered tails,False,no_term_above_threshold +9093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MobA-like N-terminal helix,False,no_term_above_threshold +9094,59224,35.28511,0.9790039,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9790039,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9995555555555555,0.9047619047619047,0.0031014621178555605,1.0,291.7210884353741,18.0,18.0,137.37557603686636,1.6332112516921354e-38,ABH Asp–His linker helix,True,assigned_and_evaluated +9095,58239,20.812246,0.7651367,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7651367,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8600699142986017,0.10925642653649545,0.017722640673460344,,6.164793867321756,1.0,16.0,2.2407170775706553,0.5681614770682746,Short amphipathic alpha helices,True,assigned_and_evaluated +9096,88058,22.761766,0.640625,Signal,keyword,88058,Signal,0.640625,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.62503846099227,0.10995392687196769,0.09127159946832078,,1.204689383252578,4.0,19.0,1.5168325647956749,0.4167641580369206,Intrinsically disordered low-complexity regions,True,assigned_and_evaluated +9097,85791,17.97817,0.72998047,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.72998047,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,13.0,0.0,1.0,Gly/Pro-rich β→α active-site scaffold,True,assigned_too_few_test_positives +9098,85762,19.967197,0.75927734,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.75927734,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,18.0,205.58965517241379,1.4365296813653038e-41,Oxidoreductase C-terminal helical cap,True,assigned_too_few_test_positives +9099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature N-terminal beta-strand,False,no_term_above_threshold +9100,36914,19.92137,0.9609375,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8413086,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,5.0,10.0,368.0308641975309,2.2463210804124676e-12,C-terminal GT basic-aromatic motif,True,assigned_too_few_test_positives +9101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,aaRS tRNA-binding/editing interfaces,False,no_term_above_threshold +9102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site adjacent metallohydrolase segments,False,no_term_above_threshold +9103,64475,20.836689,0.99121094,ACP-like superfamily,interpro,64475,ACP-like superfamily,0.99121094,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9991087344028521,0.7212586558740405,0.0057598582188746125,1.0,125.22159894674687,0.0,17.0,0.0,1.0,Amphipathic docking hotspots,True,assigned_and_evaluated +9104,50338,17.257244,0.8105469,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8105469,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane helices and P-loop cores,True,assigned_too_few_test_positives +9105,36104,24.42041,0.9584961,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9584961,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,C-terminal active-site buttress,True,assigned_too_few_test_positives +9106,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal charge-rich IDRs,False,no_term_above_threshold +9107,85364,22.076527,0.99365234,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.99365234,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,19.0,206.02684742158428,3.6533632046702945e-28,Pocket-rim beta-loop segments,True,assigned_too_few_test_positives +9108,15821,17.003202,0.68896484,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.68896484,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,18.0,0.0,1.0,Mature secreted domain core,True,assigned_too_few_test_positives +9109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metalloprotease catalytic helix,False,no_term_above_threshold +9110,82029,26.670923,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,Transmembrane helix packing/kink detector,True,assigned_too_few_test_positives +9111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site beta loops,False,no_term_above_threshold +9112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hotdog-fold acyl-binding beta-strands,False,no_term_above_threshold +9113,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteasome N-terminal helix motif,False,no_term_above_threshold +9114,36914,22.958681,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9785156,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Glycosyltransferase gating finger loop,True,assigned_too_few_test_positives +9115,61392,25.361801,0.9916992,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.9916992,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9988571428571428,0.6475417439703154,0.0031014621178555605,1.0,208.78595944871455,19.0,19.0,167.4747191011236,3.9106228067767924e-42,Solenoid C-terminal cap extension,True,assigned_and_evaluated +9116,72011,16.713537,0.9169922,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.8720703,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Periplasmic/extracellular TM loops,True,assigned_too_few_test_positives +9117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coils and acidic tails,False,no_term_above_threshold +9118,85762,22.844675,0.9501953,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9399414,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,13.0,15.0,178.17770114942527,2.3366880447792684e-28,Active-site capping helix,True,assigned_too_few_test_positives +9119,87489,22.324232,0.8911133,GPI-anchor,keyword,88161,Transmembrane helix,0.72558594,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8286349206349207,0.05919112069580454,0.0031014621178555605,,19.084908487204405,0.0,18.0,0.0,1.0,Transmembrane alpha-helical segments,True,assigned_and_evaluated +9120,64475,16.037884,0.9707031,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.94140625,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9920128890717126,0.2963239983006594,0.0057598582188746125,,51.44640493573756,0.0,17.0,0.0,1.0,Extracytoplasmic amphipathic helices,True,assigned_and_evaluated +9121,86130,16.539488,0.79541016,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,86130,Zn(2)-C6 fungal-type DNA-binding domain,0.79541016,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.5596825396825397,0.0060597566452367385,0.0031014621178555605,,1.953838678328474,0.0,14.0,0.0,1.0,Amphipathic coiled-coil oligomerization helices,True,assigned_and_evaluated +9122,87770,16.097551,0.67626953,Metalloprotease,keyword,87770,Metalloprotease,0.67626953,78,keywords,Metalloprotease,keyword:keywords:Metalloprotease,,,,,,,,10.0,17.0,110.63462609018372,7.423254226796463e-19,Metalloprotease zinc-adjacent motifs,True,assigned_too_few_test_positives +9123,37282,16.969995,0.99902344,Leucine-rich repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.92822266,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,11.0,11.0,223.29962546816478,3.734666712743484e-26,Conserved LRR beta-strand motif,True,assigned_too_few_test_positives +9124,64058,38.288147,0.90625,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.90527344,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.986784281255971,0.3943792933379807,0.006202924235711121,0.2857142857142857,63.57957607598732,18.0,18.0,113.99808795411089,4.371993551442556e-37,N-terminal Rossmann NAD(P)-binding loop,True,assigned_and_evaluated +9125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA-like helicase ATPase core,False,no_term_above_threshold +9126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical active-site subdomain,False,no_term_above_threshold +9127,88252,15.9302845,0.8676758,WD repeat,keyword,88252,WD repeat,0.8676758,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.9555774530539,0.12137907718390162,0.012405848471422242,,9.784020614430927,0.0,13.0,0.0,1.0,PPTase CoA-binding loop,True,assigned_and_evaluated +9128,37020,15.746184,0.99853516,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,18.0,816.7260273972603,1.0011499841245636e-51,Glycosyltransferase donor-binding loops,True,assigned_too_few_test_positives +9129,50806,18.754156,0.9868164,"Homeobox, conserved site",interpro,37071,Homeodomain,0.9638672,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,PAS domain helix start motif,True,assigned_too_few_test_positives +9130,81858,17.00497,0.9580078,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.70214844,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane helices,True,assigned_too_few_test_positives +9131,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-entry scaffold,False,no_term_above_threshold +9132,87276,42.599346,0.7246094,Cell membrane,keyword,88161,Transmembrane helix,0.69140625,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7808447168454795,0.5282792105608519,0.11120957022596367,0.6095617529880478,4.750303498947581,12.0,19.0,5.182406884262679,4.5586607474626246e-07,Hydrophobic membrane anchor helices,True,assigned_and_evaluated +9133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transcription factor activation IDRs,False,no_term_above_threshold +9134,85672,16.141193,0.68652344,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.68652344,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7024926209415178,0.046556656245219,0.01595037660611431,,2.9188436984849804,0.0,18.0,0.0,1.0,Helix-terminus capping residues,True,assigned_and_evaluated +9135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible active site loops,False,no_term_above_threshold +9136,87276,33.590435,0.66259766,Cell membrane,keyword,88161,Transmembrane helix,0.63964844,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7540317295126573,0.4824502576518034,0.11120957022596367,0.5258964143426295,4.338208093705658,18.0,19.0,7.77361032639402,1.3726751580475258e-15,Multi-pass transporter TM helices,True,assigned_and_evaluated +9137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidase signature catalytic domain,False,no_term_above_threshold +9138,36535,19.78203,0.96191406,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9506836,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9964842011570983,0.9013636363636363,0.004430660168365086,0.9,203.43777272727272,17.0,17.0,89.79066265060241,2.357720211227094e-33,Kinase N-lobe ATP pocket,True,assigned_and_evaluated +9139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interaction scaffolds,False,no_term_above_threshold +9140,50338,16.823782,0.80810547,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.80810547,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,19.0,0.0,1.0,TM helix N-termini and cores,True,assigned_too_few_test_positives +9141,36104,16.479996,0.9013672,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9013672,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,13.0,0.0,1.0,Cyclin-domain N-terminal activation,True,assigned_too_few_test_positives +9142,88240,17.836946,0.6352539,Virulence,keyword,88240,Virulence,0.6352539,306,keywords,Virulence,keyword:keywords:Virulence,20.0,2257.0,0.7836052749217703,0.15293481104459752,0.008861320336730172,,17.25869342638283,18.0,19.0,33.923755334281644,5.868554258102262e-27,Domain-spanning effector/toxin activation,True,assigned_and_evaluated +9143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane amphipathic helices,False,no_term_above_threshold +9144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA-like helicase ATPase segments,False,no_term_above_threshold +9145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix–loop boundary/linker signal,False,no_term_above_threshold +9146,37640,26.068392,0.98876953,EF-hand domain,interpro,46081,EF-hand domain pair,0.9819336,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,5.0,16.0,93.62594221105527,3.4160406133377107e-09,Acidic divalent cation-binding motifs,True,assigned_too_few_test_positives +9147,31094,16.366068,0.9868164,phosphopantetheine binding,go_mf,35372,ABC-type transporter activity,0.9506836,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9997774810858924,0.9497222222222222,0.004430660168365086,1.0,214.35230555555557,0.0,15.0,0.0,1.0,TM helix-loop junctions,True,assigned_and_evaluated +9148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity disordered segments,False,no_term_above_threshold +9149,50338,17.268448,0.9868164,"GPCR, rhodopsin-like, 7TM",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9272461,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,19.0,0.0,1.0,Glycine-rich helix-end hinges,True,assigned_too_few_test_positives +9150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-capping turns with Leu anchor,False,no_term_above_threshold +9151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity acidic tails,False,no_term_above_threshold +9152,30856,16.022625,0.85498047,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.8144531,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7868561278863232,0.008007520530249349,0.002215330084182543,,3.614594767354556,1.0,16.0,8.37373595505618,0.18200205763873273,Transmembrane helix boundary anchors,True,assigned_and_evaluated +9153,87276,40.247387,0.67529297,Cell membrane,keyword,88161,Transmembrane helix,0.65722656,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7935387065893951,0.49900258546818277,0.11120957022596367,0.6334661354581673,4.487047152994775,8.0,20.0,3.2821910266996976,0.00273028688048807,C-terminal TM helix C-cap,True,assigned_and_evaluated +9154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-strand/loop repeats,False,no_term_above_threshold +9155,50806,18.426394,0.96777344,"Homeobox, conserved site",interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9458008,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,Major-groove recognition helices,True,assigned_too_few_test_positives +9156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pocket lining residues,False,no_term_above_threshold +9157,31094,17.825777,0.99853516,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.95751953,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9996439697374276,0.8813455988455987,0.004430660168365086,1.0,198.91970165945165,11.0,11.0,709.7738095238095,9.193019285517015e-32,Carrier and A-domain linkers,True,assigned_and_evaluated +9158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sm/LSm-Hfq N-termini,False,no_term_above_threshold +9159,45324,15.768419,0.9926758,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.8520508,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9986678507992895,0.46928571428571425,0.002215330084182543,1.0,211.83557142857143,5.0,18.0,151.93934760448522,3.272141924785821e-10,Extracellular beta-solenoid repeats,True,assigned_and_evaluated +9160,27733,17.439718,0.7661133,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.7661133,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8039877778210268,0.1297370521339384,0.0101905183872397,,12.731153333317346,6.0,17.0,18.95739268680445,8.28064640788374e-07,Disordered transcriptional activation regions,True,assigned_and_evaluated +9161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-lobe substrate-binding activation,False,no_term_above_threshold +9162,38654,18.163263,0.81933594,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.81933594,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,13.0,0.0,1.0,Glycine-rich aspartyl protease flap,True,assigned_too_few_test_positives +9163,37894,25.382874,1.0,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8359375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,15.0,15.0,709.7738095238095,6.148192482588648e-43,Rossmann beta1-loop-alpha1 segment,True,assigned_too_few_test_positives +9164,64146,41.448936,0.92626953,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.92626953,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8165351595454319,0.5466495546406592,0.007975188303057155,0.5555555555555556,68.54378026799822,14.0,18.0,51.98642252117588,2.0401021403406839e-22,Gly–Pro helix N-cap motif,True,assigned_and_evaluated +9165,64058,22.696167,0.7871094,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7871094,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8685593274313738,0.28931830828954963,0.006202924235711121,0.21428571428571427,46.64224441496525,15.0,16.0,106.87320745697896,6.820886659830516e-30,C-terminal ligand-binding subdomain,True,assigned_and_evaluated +9166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic coupling modules,False,no_term_above_threshold +9167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BBE-like flavoprotein oxidases,False,no_term_above_threshold +9168,36914,20.801386,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,15.0,19.0,581.1013645224172,7.936822618251904e-40,Acidic donor-binding loop,True,assigned_too_few_test_positives +9169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP1-binding regulator/hijacker signature,False,no_term_above_threshold +9170,45714,19.966112,0.83691406,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,86137,Helix-loop-helix DNA-binding domain,0.8286133,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,11.0,0.0,1.0,Alpha/beta catalytic core neighborhoods,True,assigned_too_few_test_positives +9171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane helices,False,no_term_above_threshold +9172,45288,22.077003,0.9838867,CheY-like superfamily,interpro,55054,HAD superfamily,0.98095703,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,15.0,15.0,462.17829457364337,3.960299025280445e-40,REC D+3 and HK H-box,True,assigned_too_few_test_positives +9173,36091,29.27453,0.9995117,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9995117,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,5.0,18.0,104.81891701828411,2.0994382611402028e-09,Conserved donor-binding loop,True,assigned_too_few_test_positives +9174,36668,20.680353,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9863281,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,AMP-binding helix-loop-beta motif,True,assigned_too_few_test_positives +9175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal binding-domain signal,False,no_term_above_threshold +9176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-adjacent accessory extensions,False,no_term_above_threshold +9177,63951,18.859354,0.9716797,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9692383,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9909549228944247,0.49175502880386107,0.003987594151528578,0.8888888888888888,123.32123333447939,7.0,16.0,70.49780405405406,7.937035189263898e-12,Ig/FN3 beta-sandwich hydrophobic cores,True,assigned_and_evaluated +9178,49116,17.785948,0.8432617,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8432617,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8793072824156305,0.1320142399409516,0.002215330084182543,,59.591227909345555,1.0,20.0,4.351897810218978,0.32552345429018376,Phospho-regulated IDR scaffolds,True,assigned_and_evaluated +9179,88160,16.464582,0.8666992,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.8666992,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Outer membrane beta barrel turns,True,assigned_too_few_test_positives +9180,85682,22.495287,0.9086914,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.9086914,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9781810035842293,0.31371147496007723,0.011076650420912717,0.36,28.32187195939577,1.0,15.0,6.817724413950828,0.21862323143570717,Phosphate-adjacent helix N-caps,True,assigned_and_evaluated +9181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteolytically processed Ntn hydrolases,False,no_term_above_threshold +9182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory interaction module,False,no_term_above_threshold +9183,36091,20.702095,0.8989258,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.86816406,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,7.0,17.0,155.37862993298583,3.5103647786953726e-14,N-terminal catalytic accessory motif,True,assigned_too_few_test_positives +9184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-rich regulatory IDRs,False,no_term_above_threshold +9185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic scaffolds and motifs,False,no_term_above_threshold +9186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site phosphate-binding loop,False,no_term_above_threshold +9187,85364,30.71616,0.96191406,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.96191406,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,17.0,301.1161616161616,4.0879330105973736e-42,N-terminal periplasmic binding patch,True,assigned_too_few_test_positives +9188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand entry loop motif,False,no_term_above_threshold +9189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CNBD and cytosolic helices,False,no_term_above_threshold +9190,49045,18.834934,0.99560547,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8339844,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,17.0,0.0,1.0,Beta-propeller blade-edge motifs,True,assigned_too_few_test_positives +9191,28025,22.498613,0.8515625,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.640625,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9127424848215608,0.21734121416498464,0.002658396101019052,,81.75652006172838,1.0,10.0,27.100454545454546,0.06014426523955632,Switch-II/Walker-B helical lid,True,assigned_and_evaluated +9192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single residue secondary structure detector,False,no_term_above_threshold +9193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SP/TP-rich low-complexity IDRs,False,no_term_above_threshold +9194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +9195,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad mid-protein plateau activation,False,no_term_above_threshold +9196,36535,15.732989,0.8198242,Protein kinase domain,interpro,85664,Glycogen Phosphorylase B;,0.81396484,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8586337338673787,0.036328403981897565,0.004430660168365086,,8.19932077871428,0.0,17.0,0.0,1.0,Histidine kinase CA domain,True,assigned_and_evaluated +9197,45551,19.257126,0.8779297,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8779297,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,8.0,18.0,151.41841269841268,4.778760487715901e-16,F-actin capping beta TSTVIL,True,assigned_too_few_test_positives +9198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered tracts and conserved peaks,False,no_term_above_threshold +9199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Nudix diphosphate-binding core,False,no_term_above_threshold +9200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic C-terminal transferase loops,False,no_term_above_threshold +9201,38654,16.59243,0.99853516,B3 DNA binding domain,interpro,46277,"Nucleic acid-binding, OB-fold",0.9399414,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,17.0,0.0,1.0,Exposed basic beta-edge loops,True,assigned_too_few_test_positives +9202,63831,29.537592,0.84716797,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.84716797,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9120761143195617,0.4465851592177532,0.002658396101019052,0.3333333333333333,167.99045072574484,0.0,12.0,0.0,1.0,NLR/TIR signalosome cores,True,assigned_and_evaluated +9203,50338,22.53768,0.92089844,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.92089844,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Fe-S/siroheme binding motifs,True,assigned_too_few_test_positives +9204,8138,20.791203,0.6723633,translation,go_bp,88022,Ribosomal protein,0.6357422,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.4891696750902527,0.018165706690296855,0.018165706690296855,,1.0,5.0,16.0,32.23453719723183,6.546924395829588e-07,Ribosomal uS7 RNA-binding core,True,assigned_and_evaluated +9205,72011,16.526457,0.953125,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.953125,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Sensory-module edge segments,True,assigned_too_few_test_positives +9206,46078,16.02452,0.91845703,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.89746094,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,0.0,17.0,0.0,1.0,Aromatic helix N-cap pocket rims,True,assigned_too_few_test_positives +9207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short β-strand edge motif,False,no_term_above_threshold +9208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphoregulated S/T-P microtubule IDRs,False,no_term_above_threshold +9209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartyl protease gating flap,False,no_term_above_threshold +9210,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal secondary structure initiators,False,no_term_above_threshold +9211,6543,18.371838,0.9082031,NADH:ubiquinone reductase (H+-translocating),ec,87930,Plastid,0.6591797,41,ec,7.1.1.2,ec:ec:7.1.1.2,,,,,,,,10.0,15.0,451.67424242424244,2.6349235349044108e-25,Bioenergetic transmembrane helix bundles,True,assigned_too_few_test_positives +9212,36876,16.106133,0.91503906,Cytochrome P450,interpro,36876,Cytochrome P450,0.91503906,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9429369315935152,0.6678932084669789,0.003987594151528578,0.8888888888888888,167.49277461221905,0.0,11.0,0.0,1.0,Gly/Trp flexible loops and tails,True,assigned_and_evaluated +9213,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich coiled-coil termini,False,no_term_above_threshold +9214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +9215,63831,16.593634,0.9316406,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9316406,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9609062638827188,0.035938648849726515,0.002658396101019052,,13.518921742305457,0.0,14.0,0.0,1.0,Complex I NuoD core motif,True,assigned_and_evaluated +9216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical interface scaffolds,False,no_term_above_threshold +9217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide hydrolase terminal helices/tails,False,no_term_above_threshold +9218,87432,16.088234,0.6538086,Endoplasmic reticulum,keyword,88161,Transmembrane helix,0.6113281,210,keywords,Endoplasmic reticulum,keyword:keywords:Endoplasmic reticulum,37.0,2257.0,0.5911736060384709,0.09533437019304741,0.01639344262295082,0.08108108108108109,5.815396581775892,12.0,19.0,18.79010400252127,1.8362291627554279e-13,Juxtamembrane boundary helix,True,assigned_and_evaluated +9219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular CUB-like modules,False,no_term_above_threshold +9220,36668,16.43966,0.99072266,AMP-dependent synthetase/ligase domain,interpro,85664,Glycogen Phosphorylase B;,0.9814453,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,19.0,0.0,1.0,Rossmann-like glycosyltransferase loop-beta motif,True,assigned_too_few_test_positives +9221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IMPase/BPNT C-terminal strand-turn-helix,False,no_term_above_threshold +9222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear helical gene expression scaffolds,False,no_term_above_threshold +9223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent scaffold patches,False,no_term_above_threshold +9224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosidic bond-cleaving active site,False,no_term_above_threshold +9225,36449,19.734535,0.93310547,EamA domain,interpro,37071,Homeodomain,0.7841797,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,10.0,0.0,1.0,HTH DNA-binding motif,True,assigned_too_few_test_positives +9226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hemerythrin-like helices avoiding ligands,False,no_term_above_threshold +9227,24983,16.09344,0.6640625,mitochondrial inner membrane,go_cc,24983,mitochondrial inner membrane,0.6640625,179,go,GO:0005743,go_cc:go:GO:0005743,20.0,2257.0,0.6798614215467143,0.18476187668744515,0.008861320336730172,0.2,20.850377784178185,16.0,17.0,56.45259794058468,1.7557395315514075e-27,N-terminal organellar targeting signals,True,assigned_and_evaluated +9228,45714,21.115705,0.95751953,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.95751953,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,17.0,0.0,1.0,DHp coiled-coil hydrophobic heptad,True,assigned_too_few_test_positives +9229,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+ ATPase nucleotide-binding core,False,no_term_above_threshold +9230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap residues,False,no_term_above_threshold +9231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal module detector,False,no_term_above_threshold +9232,37071,16.95068,0.8383789,Homeodomain,interpro,27733,RNA polymerase II cis-regulatory region sequence-specific DNA binding,0.7807617,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,9.0,19.0,97.72154434529229,2.7674137688893324e-16,Disordered TF effector regions,True,assigned_too_few_test_positives +9233,88157,16.228785,0.7285156,Translocase,keyword,88157,Translocase,0.7285156,79,keywords,Translocase,keyword:keywords:Translocase,,,,,,,,1.0,14.0,13.308258928571428,0.1184839571015206,Cytosolic juxtamembrane capping segments,True,assigned_too_few_test_positives +9234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity disordered regions,False,no_term_above_threshold +9235,37020,17.621233,0.9921875,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.93896484,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,12.0,0.0,1.0,Response regulator REC switch,True,assigned_too_few_test_positives +9236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transpeptidase active-site loop detector,False,no_term_above_threshold +9237,88058,16.570946,0.60302734,Signal,keyword,88058,Signal,0.60302734,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5853135813455903,0.10434150117799662,0.09127159946832078,,1.143197903683196,6.0,20.0,2.1614864048338367,0.08048950337413811,Glycine detector in disordered regions,True,assigned_and_evaluated +9238,64154,16.163137,0.9711914,Cytochrome P450 superfamily,interpro,46284,FMN-binding split barrel,0.8540039,36,ip,IPR036396,interpro:ip:IPR036396,9.0,2257.0,0.9693801897983392,0.07290496073169506,0.003987594151528578,,18.28294404127064,0.0,14.0,0.0,1.0,N-terminal flavin-entry loops,True,assigned_and_evaluated +9239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical scaffolds,False,no_term_above_threshold +9240,36499,21.953674,0.99853516,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.99853516,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,11.0,19.0,442.5310391363023,2.2767460059615126e-27,Disordered interaction tails and amphipathic helices,True,assigned_too_few_test_positives +9241,37430,16.880953,0.9741211,"Signal transduction response regulator, receiver domain",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.83935547,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,5.0,15.0,161.57452574525743,2.134871029076768e-10,Sensory-effector coupling helices,True,assigned_too_few_test_positives +9242,37640,15.58942,0.96777344,EF-hand domain,interpro,46081,EF-hand domain pair,0.9628906,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,11.0,0.0,1.0,Glycine-centered beta-turn repeats,True,assigned_too_few_test_positives +9243,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated helical and IDR tethers,False,no_term_above_threshold +9244,88150,16.115988,0.6435547,Transcription regulation,keyword,87384,DNA-binding,0.63916016,1201,keywords,Transcription regulation,keyword:keywords:Transcription regulation,122.0,2257.0,0.5613007256113948,0.0610165836044684,0.05405405405405406,,1.1288067966826654,9.0,17.0,6.331807186264677,4.912172104084898e-06,Disordered segments and helix motifs,True,assigned_and_evaluated +9245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic N-terminal pre-TM region,False,no_term_above_threshold +9246,81289,22.722124,0.9604492,lambda repressor-like DNA-binding domains,gene3d,87384,DNA-binding,0.6381836,61,gene3d,1.10.260.40,gene3d:gene3d:1.10.260.40,,,,,,,,6.0,18.0,152.87435897435896,3.798204081104919e-12,Cyanase catalytic helix motif,True,assigned_too_few_test_positives +9247,64599,24.905277,0.97998047,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.97998047,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,10.0,10.0,662.4555555555555,1.2723648930030595e-28,Post-J-domain linker and helix,True,assigned_too_few_test_positives +9248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet strand-turn motif,False,no_term_above_threshold +9249,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic ligand binding hotspots,False,no_term_above_threshold +9250,88058,49.493187,0.67871094,Signal,keyword,88058,Signal,0.67871094,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7407788291763905,0.38433518827442115,0.09127159946832078,0.44660194174757284,4.210895727841595,17.0,18.0,6.804679422625042,9.227806822550483e-14,Signal peptide cleavage region,True,assigned_and_evaluated +9251,45289,15.566509,0.97509766,Dimeric alpha-beta barrel,interpro,63774,RNA-binding domain superfamily,0.9350586,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,0.0,14.0,0.0,1.0,Metal-NTP active-site beta-strand,True,assigned_too_few_test_positives +9252,85672,17.63555,0.7138672,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7084961,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.823002651458302,0.1318526368264915,0.01595037660611431,0.027777777777777776,8.266427814371982,1.0,13.0,3.0780072276716575,0.43998048794038674,Groove-lining helix-cap junctions,True,assigned_and_evaluated +9253,85664,15.865933,0.6948242,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.6948242,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Leloir-type glycosyltransferase catalytic domain,True,assigned_too_few_test_positives +9254,37894,16.86081,0.99658203,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.95947266,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,19.0,261.4956140350877,1.0046472944288676e-15,Alpha1 hydrophobe at glycine-loop,True,assigned_too_few_test_positives +9255,47717,18.076973,0.828125,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.828125,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,15.0,255.25810397553516,3.4181598419221845e-33,SF2 helicase C-terminal accessory,True,assigned_too_few_test_positives +9256,36104,23.852457,0.99072266,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99072266,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Secreted disulfide-rich signaling proteins,True,assigned_too_few_test_positives +9257,59224,29.061916,0.9770508,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9770508,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Hydrophobic AB-hydrolase core beta-strand,True,assigned_and_evaluated +9258,88147,16.46039,0.7397461,Toxin-antitoxin system,keyword,88147,Toxin-antitoxin system,0.7397461,120,keywords,Toxin-antitoxin system,keyword:keywords:Toxin-antitoxin system,10.0,2257.0,0.8447930574098798,0.7013291980505094,0.004430660168365086,0.7,158.29,18.0,18.0,236.59126984126982,1.243423145389655e-42,Short amphipathic interaction motifs,True,assigned_and_evaluated +9259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cytosolic loop helices,False,no_term_above_threshold +9260,50763,16.183655,0.9116211,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.84521484,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,11.0,0.0,1.0,SDR/MDR catalytic tyrosine,True,assigned_too_few_test_positives +9261,88058,20.418356,0.6171875,Signal,keyword,88058,Signal,0.6171875,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.590980956483458,0.09971110397402286,0.09127159946832078,,1.0924658333464543,4.0,20.0,1.4409909365558913,0.4670478563492871,Low-complexity disorder and signal/propeptides,True,assigned_and_evaluated +9262,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity acidic linkers,False,no_term_above_threshold +9263,82029,23.070372,0.9902344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6850586,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,11.0,19.0,108.88776357297029,1.55123998140076e-20,Transporter transmembrane helices,True,assigned_too_few_test_positives +9264,59224,30.810942,0.7553711,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.7553711,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.783142857142857,0.40242809914941063,0.0031014621178555605,0.42857142857142855,129.75431711145998,9.0,9.0,137.37557603686636,1.3579489286899373e-19,Serine hydrolase catalytic core,True,assigned_and_evaluated +9265,85656,16.110456,0.88916016,alpha/beta hydrolase,gene3d,88153,Transferase,0.66015625,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.952952380952381,0.11672160486728864,0.0031014621178555605,,37.63438031221006,0.0,17.0,0.0,1.0,Noncatalytic substrate cleft caps,True,assigned_and_evaluated +9266,49045,19.808622,0.99853516,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8701172,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,19.0,19.0,542.0090909090909,4.3313349653425253e-51,Beta-propeller blade signature,True,assigned_too_few_test_positives +9267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF/Palm catalytic loop-beta motif,False,no_term_above_threshold +9268,87149,25.194052,0.74658203,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.74658203,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8456306479523169,0.3322048166781567,0.012405848471422242,0.14285714285714285,26.778081115807133,0.0,18.0,0.0,1.0,Mature secreted amphipathic motif,True,assigned_and_evaluated +9269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping motif,False,no_term_above_threshold +9270,87149,20.930964,0.67089844,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.67089844,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7262064987502403,0.10691017455966897,0.012405848471422242,,8.617723713613318,0.0,15.0,0.0,1.0,Amphipathic helix polar face,True,assigned_and_evaluated +9271,46929,24.748674,0.98535156,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.77734375,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9969804618117228,0.3940476190476191,0.002215330084182543,0.4,177.87309523809526,5.0,17.0,25.267418206475675,2.228560517665702e-06,Zinc-finger Cys/His ligands,True,assigned_and_evaluated +9272,58239,16.428911,0.62353516,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.62353516,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6438035633739286,0.05756541913414877,0.017722640673460344,,3.2481287746443446,0.0,11.0,0.0,1.0,Alpha-helical enzyme cores,True,assigned_and_evaluated +9273,45290,33.99618,0.9716797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9716797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9611442479089538,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,15.0,15.0,73.42487684729065,3.1139070649328504e-28,Kinase N-lobe β-strand motif,True,assigned_and_evaluated +9274,36091,20.970123,0.7915039,GNAT domain,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7783203,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,Second TM helix-loop core,True,assigned_too_few_test_positives +9275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed functional interfaces,False,no_term_above_threshold +9276,81685,25.483376,0.97021484,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96728516,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9572197475872308,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,16.0,16.0,85.66235632183908,4.040725274098586e-31,Kinase activation loop linker,True,assigned_and_evaluated +9277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal extension activation,False,no_term_above_threshold +9278,64058,17.45265,0.82177734,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7402344,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9035093306158843,0.04756697705028992,0.006202924235711121,,7.668476228750311,4.0,17.0,26.82307951861433,2.3697348678410604e-05,Phosphate-binding beta-alpha loops,True,assigned_and_evaluated +9279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal noncatalytic segments,False,no_term_above_threshold +9280,87239,16.092184,0.77001953,CF(1),keyword,87239,CF(1),0.77001953,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9962449709432275,0.5110816251134934,0.008861320336730172,1.0,57.67556139405774,0.0,13.0,0.0,1.0,PBP/beta-lactamase KTG loop,True,assigned_and_evaluated +9281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical interaction scaffolds,False,no_term_above_threshold +9282,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed outer-membrane beta-barrel loops,False,no_term_above_threshold +9283,87697,18.32022,0.67578125,Knottin,keyword,87697,Knottin,0.67578125,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8270097801206909,0.15886971419683116,0.017279574656623838,,9.19407551133969,0.0,16.0,0.0,1.0,Conserved N-terminal regulatory motif,True,assigned_and_evaluated +9284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic C-terminal caps,False,no_term_above_threshold +9285,64058,30.401583,0.78759766,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7871094,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6680784663397237,0.2956542608181952,0.006202924235711121,0.2857142857142857,47.66369047619047,17.0,17.0,113.99808795411089,4.31985177778818e-35,Rossmann active-site lining segment,True,assigned_and_evaluated +9286,55053,17.27993,0.9824219,Chloramphenicol acetyltransferase-like domain superfamily,interpro,87566,Homeobox,0.85058594,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,19.0,0.0,1.0,Short amphipathic helix motif,True,assigned_too_few_test_positives +9287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible gly/ser-rich loop hinges,False,no_term_above_threshold +9288,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC ATPase NBD H-loop switch,False,no_term_above_threshold +9289,36354,18.556797,0.99658203,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.99609375,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,14.0,0.0,1.0,Hydrophobic beta-strand nucleotide-binding patches,True,assigned_too_few_test_positives +9290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-ATPase regulatory linker,False,no_term_above_threshold +9291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic metal binding beta strands,False,no_term_above_threshold +9292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Caspase-like C-terminal lobe,False,no_term_above_threshold +9293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PSS/PTDSS lumenal-loop activation peak,False,no_term_above_threshold +9294,85672,21.338682,0.7841797,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7729492,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8479101005553055,0.12414240074506189,0.01595037660611431,0.08333333333333333,7.783038846711241,0.0,15.0,0.0,1.0,Rossmann cofactor binding lid helix,True,assigned_and_evaluated +9295,50763,15.580649,0.98535156,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.9707031,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,15.0,0.0,1.0,Compact surface binding motifs,True,assigned_too_few_test_positives +9296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helices in IDRs,False,no_term_above_threshold +9297,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble amphipathic helical interfaces,False,no_term_above_threshold +9298,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane amphipathic helices,False,no_term_above_threshold +9299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal beta-strands,False,no_term_above_threshold +9300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical bundles and disordered linkers,False,no_term_above_threshold +9301,87586,18.336777,0.73046875,Host membrane,keyword,88161,Transmembrane helix,0.6928711,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7805149744338934,0.0860390824514814,0.01639344262295082,,5.2483840295403645,6.0,17.0,22.79816455292843,2.841625974922701e-07,Juxtamembrane TM exit motif,True,assigned_and_evaluated +9302,85762,27.30436,0.9067383,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.90234375,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,FAD-binding core beta-strand motif,True,assigned_too_few_test_positives +9303,64148,22.233494,0.7182617,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7026367,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8035252339965195,0.3130094334035358,0.008418254319893664,0.5789473684210527,37.18222585219897,5.0,19.0,23.417517674783973,3.438563078258042e-06,Conserved short-motif peaks,True,assigned_and_evaluated +9304,45289,16.818525,1.0,Dimeric alpha-beta barrel,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.7758789,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,16.0,17.0,850.2103386809268,3.4125728124381696e-46,Hydrophobic aromatic beta-strand motif,True,assigned_too_few_test_positives +9305,72011,16.980621,0.9824219,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.92822266,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,PAS-family β-strand hydrophobic signature,True,assigned_too_few_test_positives +9306,63831,27.623121,0.9970703,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9970703,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9991855471642234,0.6218253968253968,0.002658396101019052,1.0,233.90998677248677,16.0,20.0,196.2831275720165,8.446834551509739e-35,SCF F-box helix-loop core,True,assigned_and_evaluated +9307,47529,32.366898,0.98095703,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.98095703,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9970018964747881,0.6461311029978792,0.007089056269384138,0.875,91.14486871663834,15.0,18.0,64.4412019022914,1.0108141398209011e-25,Ig/FN3 ligand-binding loops,True,assigned_and_evaluated +9308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent aromatic/basic motif,False,no_term_above_threshold +9309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-sensing and HEPN surfaces,False,no_term_above_threshold +9310,59237,17.527798,0.98535156,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.98535156,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,0.0,17.0,0.0,1.0,Beta-edge loop binding motif,True,assigned_too_few_test_positives +9311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase catalytic core,False,no_term_above_threshold +9312,30398,15.62973,0.6411133,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.60595703,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.629847000728568,0.12520228214538726,0.004873726185201595,0.09090909090909091,25.68923189110355,16.0,20.0,57.604830917874395,2.42360630910485e-26,P-loop NTPase active site,True,assigned_and_evaluated +9313,63831,16.55338,0.8935547,F-box-like domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.82958984,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8648378498445135,0.010710222924213454,0.002658396101019052,,4.028828856658294,0.0,14.0,0.0,1.0,Helix N-cap/coiled-coil residues,True,assigned_and_evaluated +9314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting helices and loops,False,no_term_above_threshold +9315,59229,19.942335,0.91845703,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.86376953,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.953573235763497,0.11106226241451732,0.0101905183872397,,10.898588098676765,0.0,16.0,0.0,1.0,Beta-strand core enrichment,True,assigned_and_evaluated +9316,36354,22.272194,0.98095703,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9765625,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,19.0,0.0,1.0,Soluble amphipathic regulatory helices,True,assigned_too_few_test_positives +9317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Distal noncatalytic C-terminal segments,False,no_term_above_threshold +9318,31094,16.511541,0.9790039,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8378906,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9972852692478861,0.4371977940360293,0.004430660168365086,1.0,98.67554211393183,0.0,14.0,0.0,1.0,Solvent-exposed surface docking patches,True,assigned_and_evaluated +9319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich strand–turn–helix motif,False,no_term_above_threshold +9320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Boundary-flanking charged/proline motifs,False,no_term_above_threshold +9321,64596,32.404583,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,15.0,16.0,576.2338917525774,7.295861706637928e-41,MBL/MPE dinuclear hydrolase scaffold,True,assigned_too_few_test_positives +9322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-binding β-sheet loops,False,no_term_above_threshold +9323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short low-complexity peptide cores,False,no_term_above_threshold +9324,25169,18.856697,0.86865234,pilus,go_cc,25169,pilus,0.86865234,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9987566607460036,0.6222222222222222,0.002215330084182543,1.0,280.87111111111113,0.0,13.0,0.0,1.0,Deuterolysin propeptide motif,True,assigned_and_evaluated +9325,45288,18.3515,1.0,CheY-like superfamily,interpro,85664,Glycogen Phosphorylase B;,0.8310547,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,18.0,18.0,462.17829457364337,1.3033289657798122e-47,REC output helix and linker,True,assigned_too_few_test_positives +9326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic–aromatic pocket‑rim loops,False,no_term_above_threshold +9327,72011,20.723064,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.92285156,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,16.0,17.0,555.582993593477,3.3943739850444213e-43,ATP/PPi-binding A-motif loop,True,assigned_too_few_test_positives +9328,41979,21.481304,0.91845703,Immunoglobulin-like domain,interpro,63951,Immunoglobulin-like domain superfamily,0.8930664,53,ip,IPR007110,interpro:ip:IPR007110,,,,,,,,14.0,15.0,172.2794633642931,8.30534431187282e-31,Terminal anchoring/processing modules,True,assigned_too_few_test_positives +9329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site helix-capping hotspots,False,no_term_above_threshold +9330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal soluble domains,False,no_term_above_threshold +9331,87857,18.95875,0.61865234,Nucleus,keyword,87857,Nucleus,0.61865234,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6604559653568219,0.2230643333252515,0.06247230837394772,0.1773049645390071,3.57061134975243,12.0,16.0,4.5442835365853655,7.428708413124339e-07,Ser/Thr/Pro-rich regulatory IDRs,True,assigned_and_evaluated +9332,87108,15.825433,0.89941406,ANK repeat,keyword,88009,Repeat,0.6699219,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8637307236061684,0.02665127559228783,0.003987594151528578,,6.68354766797707,0.0,13.0,0.0,1.0,Hydrophobic aliphatic core packing,True,assigned_and_evaluated +9333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional beta-strand cap loops,False,no_term_above_threshold +9334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-residue functional microswitches,False,no_term_above_threshold +9335,87276,26.798811,0.61376953,Cell membrane,keyword,88159,Transmembrane,0.6044922,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7291194146643734,0.3983704199902444,0.11120957022596367,0.50199203187251,3.582159513617457,16.0,19.0,6.9098758456835725,3.4349742150003185e-12,TM helix C-terminal interfacial caps,True,assigned_and_evaluated +9336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich disordered regulatory regions,False,no_term_above_threshold +9337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PDZ carboxylate-binding loop mimicry,False,no_term_above_threshold +9338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface loops with cysteine hotspots,False,no_term_above_threshold +9339,38317,22.659477,0.97509766,Pentatricopeptide repeat,interpro,88154,Transit peptide,0.87890625,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.911873015873016,0.2127678236525835,0.0031014621178555605,0.2857142857142857,68.60242542626871,0.0,18.0,0.0,1.0,Chloroplast transit peptide activation,True,assigned_and_evaluated +9340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structural glycine positions,False,no_term_above_threshold +9341,59224,15.826101,0.9008789,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8046875,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9280952380952381,0.026684697407159508,0.0031014621178555605,,8.603908863994144,0.0,17.0,0.0,1.0,APRT conserved motif detector,True,assigned_and_evaluated +9342,85672,19.544582,0.7548828,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.7548828,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7875018760318175,0.1065602595908734,0.01595037660611431,0.027777777777777776,6.680736274905591,4.0,17.0,9.41508093170154,0.0012587916594561115,Helix-end patches near active sites,True,assigned_and_evaluated +9343,85364,16.76723,0.9951172,Periplasmic binding protein-like II,gene3d,37446,F-box domain,0.8183594,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,Internal hydrophobic hinge helices,True,assigned_too_few_test_positives +9344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix interface activation,False,no_term_above_threshold +9345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,acidic disordered assembly tails,False,no_term_above_threshold +9346,50869,17.8437,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.6694336,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,20.0,20.0,917.2461538461538,5.886799965512069e-58,HTH DNA-binding motifs,True,assigned_too_few_test_positives +9347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site alpha helices,False,no_term_above_threshold +9348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro-rich low-complexity IDRs,False,no_term_above_threshold +9349,64475,15.611416,0.8251953,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.80810547,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.8415946798299739,0.25849314903756787,0.0057598582188746125,0.07692307692307693,44.87838749059928,1.0,14.0,38.023596938775505,0.04344145960883729,Rossmann N-terminal amphipathic helix,True,assigned_and_evaluated +9350,46284,15.614252,0.9638672,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9638672,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,8.0,14.0,681.3828571428571,1.102190610972512e-21,Glycine-rich active-site cap,True,assigned_too_few_test_positives +9351,38873,17.60699,0.7963867,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.640625,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.897424511545293,0.6647287803025508,0.002215330084182543,0.8,300.05857142857144,10.0,10.0,171.32471264367817,1.12424031081604e-22,ABC NBD pre-Walker A microelement,True,assigned_and_evaluated +9352,85364,24.473005,0.9765625,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9765625,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,14.0,19.0,221.87506645401382,5.674299009632219e-31,Ligand-cleft hinge loops,True,assigned_too_few_test_positives +9353,87697,24.883923,0.90478516,Knottin,keyword,87697,Knottin,0.90478516,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.871112806640309,0.0596589395610009,0.017279574656623838,,3.452569912543052,0.0,17.0,0.0,1.0,Short structured segment detector,True,assigned_and_evaluated +9354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure boundary motif,False,no_term_above_threshold +9355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial transmembrane helix motif,False,no_term_above_threshold +9356,87697,17.00966,0.85009766,Knottin,keyword,88058,Signal,0.7109375,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9799542207116599,0.2838855553325368,0.017279574656623838,,16.428966625270142,0.0,18.0,0.0,1.0,Mature extracellular domains,True,assigned_and_evaluated +9357,37690,33.893925,0.99365234,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9873047,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9956190476190476,0.4584467120181406,0.0031014621178555605,0.7142857142857143,147.81631843213475,0.0,14.0,0.0,1.0,REC α5 output face,True,assigned_and_evaluated +9358,69819,17.441833,0.86816406,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8618164,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,Phosphate-binding loop-helix module,True,assigned_too_few_test_positives +9359,59224,15.661257,0.76220703,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.76220703,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9014285714285715,0.2177938952374136,0.0031014621178555605,0.14285714285714285,70.22297450726322,6.0,16.0,51.51584101382488,2.221118695060156e-09,Noncatalytic amphipathic alpha-helices,True,assigned_and_evaluated +9360,50338,18.59819,0.7895508,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.7895508,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,DHp C-terminal helix-loop,True,assigned_too_few_test_positives +9361,39971,17.893623,0.99902344,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98535156,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,16.0,16.0,662.4555555555555,3.831366179140002e-45,Metal-coordinating phosphodiesterase neighborhoods,True,assigned_too_few_test_positives +9362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IQ calmodulin-binding motif,False,no_term_above_threshold +9363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminal tail activation,False,no_term_above_threshold +9364,87882,16.26926,0.66552734,Palmitate,keyword,87882,Palmitate,0.66552734,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8188953057900191,0.1286639098114508,0.002658396101019052,,48.39907407407407,2.0,19.0,7.012172890326374,0.053991397200025014,Mature soluble exported domain,True,assigned_and_evaluated +9365,87277,16.08511,0.6508789,Cell outer membrane,keyword,87277,Cell outer membrane,0.6508789,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.709968253968254,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,13.0,16.0,119.0222665847666,9.873938461068826e-26,Post-cleavage periplasmic/IMS N-terminus,True,assigned_and_evaluated +9366,25167,15.744834,0.6386719,cell outer membrane,go_cc,25167,cell outer membrane,0.6386719,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7465478841870824,0.3451488645106051,0.005316792202038104,0.25,64.91674893336965,20.0,20.0,136.43249427917618,1.5446348002941576e-42,C-terminal outer-membrane beta-signal,True,assigned_and_evaluated +9367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic lipid-enzyme cytosolic loops,False,no_term_above_threshold +9368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical membrane anchors,False,no_term_above_threshold +9369,52236,23.234562,0.93603516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8911133,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,10.0,18.0,124.05534748231378,2.9584673239211273e-19,N-terminal TPR/SEL1 leaders,True,assigned_too_few_test_positives +9370,36668,15.701245,0.97216797,AMP-dependent synthetase/ligase domain,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.71972656,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,14.0,14.0,532.3303571428571,2.0509194733270867e-38,Adenylation SBD2 beta-strand motif,True,assigned_too_few_test_positives +9371,46274,17.044123,0.6977539,Ribonuclease H-like superfamily,interpro,46274,Ribonuclease H-like superfamily,0.6977539,72,ip,IPR012337,interpro:ip:IPR012337,38.0,2257.0,0.5565985152154835,0.056150864840282,0.016836508639787327,0.02631578947368421,3.3350658406451705,13.0,14.0,225.05023228803714,3.876331592419311e-30,RNase H-like nuclease fold core,True,assigned_and_evaluated +9372,47529,20.191097,0.95654297,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.95654297,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9780650379294957,0.45722314629369,0.007089056269384138,0.6875,64.49704007405364,9.0,20.0,34.798249027237354,3.1277705730455488e-12,Functional beta-fold surface loops,True,assigned_and_evaluated +9373,-1,,,,,-1,,,0,,,,,,,,,,,,,,,K/E-rich helical interaction surfaces,False,no_term_above_threshold +9374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly arms,False,no_term_above_threshold +9375,85656,23.971638,0.99072266,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7661133,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9984761904761905,0.889400921658986,0.0031014621178555605,0.8571428571428571,286.7682685977616,19.0,19.0,141.281990521327,8.965631807545709e-41,AB-hydrolase nucleophile elbow,True,assigned_and_evaluated +9376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix-loop-helix junctions,False,no_term_above_threshold +9377,25884,19.814758,0.8520508,host cell membrane,go_cc,88159,Transmembrane,0.7919922,259,go,GO:0033644,go_cc:go:GO:0033644,24.0,2257.0,0.8917002537692192,0.31626444112932084,0.010633584404076208,0.20833333333333334,29.74203515120321,1.0,20.0,6.683968609865471,0.22227518644121014,Signal and transmembrane helices,True,assigned_and_evaluated +9378,85669,16.79998,0.9345703,3.40.50.2300,gene3d,85388,Glutaredoxin,0.7734375,62,gene3d,3.40.50.2300,gene3d:gene3d:3.40.50.2300,5.0,2257.0,0.8793072824156306,0.42393200950578,0.002215330084182543,0.4,191.3629090909091,16.0,17.0,239.80291603821018,2.0288315103653354e-37,Loop-to-helix N-cap motifs,True,assigned_and_evaluated +9379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine recombinase catalytic core,False,no_term_above_threshold +9380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich low-complexity repeats,False,no_term_above_threshold +9381,87586,18.150795,0.7109375,Host membrane,keyword,88161,Transmembrane helix,0.703125,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.8151631361090821,0.09341117800864276,0.01639344262295082,,5.698081858527209,0.0,16.0,0.0,1.0,Juxtamembrane interhelical loops,True,assigned_and_evaluated +9382,37894,22.34677,0.8779297,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8671875,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Rossmann NAD(P)-binding loop-helix,True,assigned_too_few_test_positives +9383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-output linker helix,False,no_term_above_threshold +9384,48880,21.104443,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48883,Pyridoxal phosphate-dependent transferase,1.0,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,PLP pre-lysine gating loop,True,assigned_too_few_test_positives +9385,87326,23.483383,0.609375,Coiled coil,keyword,87326,Coiled coil,0.609375,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.592872838840748,0.18862764861579706,0.03943287549844927,0.20224719101123595,4.783512392425326,16.0,18.0,11.20669157209652,7.469626005007722e-16,Long coiled-coil scaffolds,True,assigned_and_evaluated +9386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered polar TF tails,False,no_term_above_threshold +9387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helices and processing motifs,False,no_term_above_threshold +9388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp beta-sheet scaffold,False,no_term_above_threshold +9389,64026,17.499773,0.83203125,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.6616211,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9224788982674368,0.018456497219672376,0.002658396101019052,,6.942719037466759,0.0,17.0,0.0,1.0,Transmembrane helix hydrophobic core,True,assigned_and_evaluated +9390,36449,19.078623,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,13.0,19.0,728.452067669173,1.4258692583530252e-35,Transmembrane helix loop junctions,True,assigned_too_few_test_positives +9391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphosugar isomerization catalytic core,False,no_term_above_threshold +9392,37020,16.721539,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,14.0,14.0,816.7260273972603,4.5038068696446367e-41,ALG2 GT-B loop motif,True,assigned_too_few_test_positives +9393,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal RecA-like lobe,False,no_term_above_threshold +9394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Di-glycine β-edge/loop motif,False,no_term_above_threshold +9395,88058,21.822308,0.63427734,Signal,keyword,88058,Signal,0.63427734,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6376548498719545,0.11222347876620434,0.09127159946832078,,1.229555298909336,3.0,20.0,1.0807432024169183,0.8334769282943363,Short terminal targeting segment,True,assigned_and_evaluated +9396,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant-biased S/T/P-rich IDRs,False,no_term_above_threshold +9397,45290,17.148811,0.84814453,Protein kinase-like domain superfamily,interpro,87855,Nucleotide-binding,0.7270508,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.906108597285068,0.04392423145046251,0.0057598582188746125,,7.625922337207221,0.0,15.0,0.0,1.0,Beta sheet core hydrophobes,True,assigned_and_evaluated +9398,39971,20.115477,0.8149414,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.78564453,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,15.0,17.0,584.5196078431372,1.741555167543374e-40,Metallophosphoesterase catalytic domain,True,assigned_too_few_test_positives +9399,38317,16.69345,0.96777344,Pentatricopeptide repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.79785156,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9071428571428573,0.01776578860651539,0.0031014621178555605,,5.728197840700748,0.0,14.0,0.0,1.0,Kinase catalytic fold hydrophobic core,True,assigned_and_evaluated +9400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global low-complexity/disorder activation,False,no_term_above_threshold +9401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-binding beta-sheet cores,False,no_term_above_threshold +9402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal hydrophobic motif,False,no_term_above_threshold +9403,63960,24.77882,0.9189453,FAD/NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.80371094,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,N-terminal FAD-binding helix,True,assigned_too_few_test_positives +9404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity tails,False,no_term_above_threshold +9405,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic RNA/DNA-binding surfaces,False,no_term_above_threshold +9406,37894,30.007185,0.99658203,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9277344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,2.0,18.0,78.8637566137566,0.0005299721974853307,SDR Rossmann glycine loop,True,assigned_too_few_test_positives +9407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phe-anchored hydrophobic motifs,False,no_term_above_threshold +9408,32555,18.020916,0.8730469,"proton-transporting ATP synthase activity, rotational mechanism",go_mf,87109,ATP synthesis,0.796875,70,go,GO:0046933,go_mf:go:GO:0046933,23.0,2257.0,0.9992020551944261,0.9721467391304348,0.0101905183872397,0.9565217391304348,95.39718218336483,14.0,15.0,335.21847389558235,7.283149953202633e-35,Elongated coiled-coil peripheral stalks,True,assigned_and_evaluated +9409,47717,18.255184,0.9980469,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.76220703,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,17.0,17.0,273.49082568807336,2.0529456742038635e-41,Helicase motif Ia loop,True,assigned_too_few_test_positives +9410,88009,16.909414,0.6166992,Repeat,keyword,88009,Repeat,0.6166992,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6254675864962185,0.15484792394743052,0.07266282676118742,0.042682926829268296,2.1310473435936017,12.0,20.0,5.319345724907063,4.309452283718713e-07,Hydrophobic residues in disordered repeats,True,assigned_and_evaluated +9411,37341,19.22798,0.9970703,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9970703,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9988540109616343,0.8803571737624198,0.011962782454585734,1.0,73.5913385622882,19.0,20.0,138.1462195121951,8.70422654690493e-40,WD propeller boundary loops,True,assigned_and_evaluated +9412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histone-reader and DNA-binding domains,False,no_term_above_threshold +9413,85672,17.368141,0.7373047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7348633,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.864719345640102,0.12801426477985195,0.01595037660611431,0.027777777777777776,8.02578321133683,10.0,13.0,30.780072276716574,5.6325263107026746e-14,P-loop-adjacent amphipathic helices,True,assigned_and_evaluated +9414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral docking interface segments,False,no_term_above_threshold +9415,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic mechanotransmission and gating residues,False,no_term_above_threshold +9416,87317,18.619469,0.7739258,Cleavage on pair of basic residues,keyword,88058,Signal,0.6689453,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.8680973895582329,0.07116254818468888,0.007089056269384138,,10.038366953302676,2.0,17.0,9.935177470421596,0.028598620581562203,Secretory acidic PTM-rich IDRs,True,assigned_and_evaluated +9417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GRAM/PH/TLDc interaction modules,False,no_term_above_threshold +9418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH16 catalytic glutamate dyad,False,no_term_above_threshold +9419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cys/His metal-binding microdomains,False,no_term_above_threshold +9420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Schlafen/SAMD9 strand-helix motif,False,no_term_above_threshold +9421,63951,21.04892,0.9838867,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.87597656,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9983689205219454,0.6531223406223408,0.003987594151528578,1.0,163.78856919829147,15.0,15.0,161.13783783783785,2.7075535945833885e-33,Glycosylated extracellular linkers and stalk,True,assigned_and_evaluated +9422,55054,18.164257,0.9951172,HAD superfamily,interpro,55054,HAD superfamily,0.9951172,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.9951154529307282,0.5589247311827956,0.002215330084182543,0.6,252.29862365591396,0.0,8.0,0.0,1.0,Basic amphipathic phosphate-binding segments,True,assigned_and_evaluated +9423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ectodomains flanking secretory entry,False,no_term_above_threshold +9424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and disordered ectodomains,False,no_term_above_threshold +9425,50869,19.878798,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.66748047,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,19.0,19.0,917.2461538461538,1.6344645258281847e-55,Pre-HTH helix-loop motif,True,assigned_too_few_test_positives +9426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-adjacent structured segments,False,no_term_above_threshold +9427,82029,16.422203,0.7104492,MFS general substrate transporter like domains,gene3d,82029,MFS general substrate transporter like domains,0.7104492,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,11.0,0.0,1.0,ABC TMD helix-loop junction,True,assigned_too_few_test_positives +9428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal S/T-rich disordered motifs,False,no_term_above_threshold +9429,29104,15.831859,0.7939453,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.62841797,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,9.0,14.0,275.73946557040085,8.24670299296037e-21,Transmembrane helix hydrophobic cores,True,assigned_too_few_test_positives +9430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich hinge loops,False,no_term_above_threshold +9431,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic flexible anion-binding loops,False,no_term_above_threshold +9432,46274,20.636545,0.90966797,Ribonuclease H-like superfamily,interpro,46274,Ribonuclease H-like superfamily,0.90966797,72,ip,IPR012337,interpro:ip:IPR012337,38.0,2257.0,0.5546417305092385,0.10145771083655865,0.016836508639787327,0.07894736842105263,6.026054035739813,1.0,15.0,16.157452574525742,0.09858605764092679,Surface helix loop interfacial patches,True,assigned_and_evaluated +9433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil apex and stalks,False,no_term_above_threshold +9434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic β-strand–turn motifs,False,no_term_above_threshold +9435,72011,22.187744,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9609375,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,10.0,15.0,393.53795379537956,1.0960119385856007e-24,ANL adenylate-binding segment,True,assigned_too_few_test_positives +9436,82029,24.862043,0.99365234,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.98828125,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,18.0,188.0788643533123,6.824310871704072e-41,Hydrophobic MFS transmembrane helices,True,assigned_too_few_test_positives +9437,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclase/PDE active-site rim helix,False,no_term_above_threshold +9438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter C-terminal cytosolic tails,False,no_term_above_threshold +9439,84879,17.270708,0.99902344,"Histidine kinase-like ATPase, C-terminal domain",gene3d,64620,Histidine kinase/HSP90-like ATPase superfamily,0.99853516,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,17.0,17.0,327.5879120879121,1.027565445798913e-42,Bergerat F-helix adenine pocket,True,assigned_too_few_test_positives +9440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Whole-protein ciliary/axonemal signature,False,no_term_above_threshold +9441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic alpha-helix structural marker,False,no_term_above_threshold +9442,85762,22.517479,0.8959961,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.89208984,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,Redox-core beta-loop-beta motif,True,assigned_too_few_test_positives +9443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartyl protease DTG/DSG motif,False,no_term_above_threshold +9444,64507,15.849972,0.8666992,Ankyrin repeat-containing domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.80615234,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9084865559509687,0.03020523093765038,0.003987594151528578,,7.574800691808546,0.0,19.0,0.0,1.0,CATCHR LxxLPxxLxx helical motif,True,assigned_and_evaluated +9445,4066,17.397015,0.7631836,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.7631836,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.5955595026642984,0.0684389307340127,0.002215330084182543,,30.893333333333338,0.0,16.0,0.0,1.0,Interface-gating helices and rims,True,assigned_and_evaluated +9446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic surface interaction helix,False,no_term_above_threshold +9447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-portal helices and loops,False,no_term_above_threshold +9448,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C catalytic lumenal loop,False,no_term_above_threshold +9449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-centered Claisen condensation site,False,no_term_above_threshold +9450,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial coiled-coil oligomerization domains,False,no_term_above_threshold +9451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic sensory-domain activation,False,no_term_above_threshold +9452,47717,18.571892,0.9477539,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9477539,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,11.0,248.62802335279397,1.1046647748237842e-23,SF2 helicase RecA1 inter-motif,True,assigned_too_few_test_positives +9453,61392,23.539549,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,167.4747191011236,5.14338702087321e-40,LRR Asn ladder position,True,assigned_and_evaluated +9454,59224,44.323387,0.92578125,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.92578125,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.927142857142857,0.8218716374454078,0.0031014621178555605,0.8571428571428571,264.9948979591836,15.0,16.0,128.78960253456222,4.286832372759693e-31,alpha/beta-hydrolase catalytic His module,True,assigned_and_evaluated +9455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core beta-strands,False,no_term_above_threshold +9456,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered regulatory tails,False,no_term_above_threshold +9457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAM-like N-terminal helix detector,False,no_term_above_threshold +9458,37446,21.210056,0.7363281,F-box domain,interpro,37446,F-box domain,0.7363281,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.636063492063492,0.1688819967508492,0.0031014621178555605,0.2857142857142857,54.45238095238095,16.0,19.0,196.12171052631575,4.154510798891246e-35,C-terminal F-box hydrophobic patch,True,assigned_and_evaluated +9459,47717,15.940322,0.8027344,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6870117,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,12.0,0.0,1.0,Walker B/switch region motif,True,assigned_too_few_test_positives +9460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal-tail activation bias,False,no_term_above_threshold +9461,45804,20.195301,0.9746094,Major facilitator superfamily,interpro,87276,Cell membrane,0.6274414,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,16.0,0.0,1.0,Multi-pass flippase transporters,True,assigned_too_few_test_positives +9462,38873,21.301575,0.97753906,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.87353516,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9978685612788633,0.7088235294117646,0.002215330084182543,0.6,319.96294117647057,9.0,9.0,171.32471264367817,1.8650004750458193e-20,ABC NBD post-Walker A loop,True,assigned_and_evaluated +9463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-enriched helix–coil boundary segments,False,no_term_above_threshold +9464,87326,44.387157,0.8017578,Coiled coil,keyword,87326,Coiled coil,0.8017578,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8246014552842157,0.3943635070415821,0.03943287549844927,0.3258426966292135,10.000881296548885,19.0,19.0,12.607528018608585,3.1804487015974775e-21,Coiled-coil heptad-face preference,True,assigned_and_evaluated +9465,81799,21.954054,0.80371094,1.10.8.60,gene3d,81799,1.10.8.60,0.80371094,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,11.0,11.0,578.8446601941747,9.253800446894493e-31,Accessory regulatory helical modules,True,assigned_too_few_test_positives +9466,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding loops,False,no_term_above_threshold +9467,52236,21.376814,0.9970703,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9824219,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,19.0,188.04178986792823,8.014915469768169e-35,TPR/SEL1 repeat hydrophobic core,True,assigned_too_few_test_positives +9468,87276,44.813824,0.7817383,Cell membrane,keyword,88161,Transmembrane helix,0.76416016,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.9005473618983688,0.7508982059669471,0.11120957022596367,0.8047808764940239,6.752100601065337,15.0,17.0,7.240127264778744,4.465057938108189e-12,Transmembrane helices and basic flanks,True,assigned_and_evaluated +9469,36104,19.155155,0.9003906,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9003906,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +9470,47529,25.93083,0.90966797,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.90966797,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9902387327086122,0.29951436550200883,0.007089056269384138,,42.25024518362712,2.0,17.0,9.097581445029373,0.03365380503958057,Edge beta-strand interactions,True,assigned_and_evaluated +9471,85364,23.361727,0.8286133,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8286133,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,SBP N-terminal beta-alpha-beta motif,True,assigned_too_few_test_positives +9472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arp2/3 conserved alpha-helices,False,no_term_above_threshold +9473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic acidic linker/hinge regions,False,no_term_above_threshold +9474,59224,17.716862,0.92822266,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8286133,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9382857142857143,0.03848794185618298,0.0031014621178555605,,12.409612109914999,4.0,17.0,32.32366494985091,1.1472213482897399e-05,Beta-strand N-cap motif,True,assigned_and_evaluated +9475,87930,16.398586,0.6430664,Plastid,keyword,88161,Transmembrane helix,0.6098633,424,keywords,Plastid,keyword:keywords:Plastid,33.0,2257.0,0.40466944626117285,0.012804791596909263,0.014621178555604785,,0.8757701404310365,0.0,17.0,0.0,1.0,Basic N-terminal tails,True,assigned_and_evaluated +9476,45714,21.89231,0.94677734,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8847656,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,Histidine kinase DHp coiled-coil,True,assigned_too_few_test_positives +9477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal interaction/targeting platforms,False,no_term_above_threshold +9478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase coupling surface,False,no_term_above_threshold +9479,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix-loop interface hotspots,False,no_term_above_threshold +9480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature secretory catalytic cores,False,no_term_above_threshold +9481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transit peptides and disordered termini,False,no_term_above_threshold +9482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular flexible loop regions,False,no_term_above_threshold +9483,88022,16.102417,0.734375,Ribosomal protein,keyword,87149,Amphibian defense peptide,0.7290039,279,keywords,Ribosomal protein,keyword:keywords:Ribosomal protein,50.0,2257.0,0.8698504757589487,0.15691614824271094,0.022153300841825433,,7.083194931675972,1.0,12.0,7.505161127895266,0.20104608265424836,Well-folded cores in energy/translation assemblies,True,assigned_and_evaluated +9484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS N-cap coupling helices,False,no_term_above_threshold +9485,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly adapter,False,no_term_above_threshold +9486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane helices,False,no_term_above_threshold +9487,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand edge DNA-recognition patches,False,no_term_above_threshold +9488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DSBH non-heme Fe(II) oxygenase fold,False,no_term_above_threshold +9489,72011,17.146439,0.9824219,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.94091797,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,β-solenoid acyltransferase loops,True,assigned_too_few_test_positives +9490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered RNA/ribosome tails,False,no_term_above_threshold +9491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Permease transmembrane helix terminus signal,False,no_term_above_threshold +9492,36535,22.195051,0.953125,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9291992,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9482866043613707,0.9004430660168364,0.004430660168365086,0.9,203.23,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Activation segment APE region,True,assigned_and_evaluated +9493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad mixed-structure activation,False,no_term_above_threshold +9494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Clan SB peptidase core,False,no_term_above_threshold +9495,87276,33.37159,0.6386719,Cell membrane,keyword,88161,Transmembrane helix,0.60839844,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7579333712011376,0.5504315251547006,0.11120957022596367,0.549800796812749,4.9494978178253355,12.0,16.0,6.154108175061933,2.4137614889979377e-08,Internal transmembrane helix bundles,True,assigned_and_evaluated +9496,36886,17.055676,0.6875,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.6875,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.7469430858159182,0.12271382250890447,0.003544528134692069,,34.620637175324674,0.0,14.0,0.0,1.0,Flavoprotein C-terminal helix GGDEF Phe,True,assigned_and_evaluated +9497,58239,16.893904,0.72753906,P-loop containing nucleoside triphosphate hydrolase,interpro,87855,Nucleotide-binding,0.69873047,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8371222372575552,0.05913796617068392,0.017722640673460344,,3.3368597411808403,0.0,15.0,0.0,1.0,CLE C-termini and TM helix-ends,True,assigned_and_evaluated +9498,36091,15.715608,0.95166016,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.92871094,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,13.0,0.0,1.0,OmpR/PhoB XGADDY motif,True,assigned_too_few_test_positives +9499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small‑polar interrupted TM helices,False,no_term_above_threshold +9500,47529,16.052237,0.7236328,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7236328,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7616577420794288,0.07193483121288938,0.007089056269384138,,10.147307127968208,1.0,18.0,4.296080126819426,0.3291696656304877,Exposed β‑rich surface domains,True,assigned_and_evaluated +9501,82029,23.960245,0.9995117,MFS general substrate transporter like domains,gene3d,87276,Cell membrane,0.6098633,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Transmembrane boundary anchor residues,True,assigned_too_few_test_positives +9502,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-late motif hotspots and IDRs,False,no_term_above_threshold +9503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal alpha/beta catalytic helices,False,no_term_above_threshold +9504,59211,25.153358,0.88916016,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.88916016,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9552688172043011,0.6155676755143817,0.011076650420912717,0.72,55.57344974543838,11.0,14.0,191.98799765807965,4.5573835704420735e-24,GT-A DxD catalytic core,True,assigned_and_evaluated +9505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase H-like nuclease motif,False,no_term_above_threshold +9506,37341,25.608362,0.99658203,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99658203,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999003487792726,0.9925755248335892,0.011962782454585734,1.0,82.971961464793,19.0,20.0,138.1462195121951,8.70422654690493e-40,WD40 beta-strand blade anchors,True,assigned_and_evaluated +9507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral signal-peptide Thr motif,False,no_term_above_threshold +9508,81685,26.9661,0.9707031,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9316406,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9576837416481069,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,14.0,14.0,85.66235632183908,2.52616524771724e-27,Kinase C-lobe core helix,True,assigned_and_evaluated +9509,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic MoRF helices,False,no_term_above_threshold +9510,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal amphipathic assembly motif,False,no_term_above_threshold +9511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure junction signal,False,no_term_above_threshold +9512,29104,16.506742,0.79052734,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.640625,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,18.0,0.0,1.0,TM boundary glycine motifs,True,assigned_too_few_test_positives +9513,49116,15.946084,0.6972656,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.6972656,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.6948934280639432,0.11799586471717619,0.002215330084182543,,53.263333333333335,7.0,14.0,43.518978102189784,1.7294128985256685e-10,Charged low-complexity nuclear IDRs,True,assigned_and_evaluated +9514,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta-strand head domains,False,no_term_above_threshold +9515,52910,15.636311,0.875,"Polyketide synthase, phosphopantetheine-binding domain",interpro,87913,Phosphopantetheine,0.77734375,30,ip,IPR020806,interpro:ip:IPR020806,10.0,2257.0,0.8950600801068092,0.3211615755444107,0.004430660168365086,0.6,72.4861676003735,0.0,19.0,0.0,1.0,BON domain membrane-binding,True,assigned_and_evaluated +9516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed receptor-binding loops,False,no_term_above_threshold +9517,72011,16.553354,0.9580078,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.67041016,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,11.0,0.0,1.0,ABC NBD pre-P-loop beta-strand,True,assigned_too_few_test_positives +9518,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal periplasmic sensor loop,False,no_term_above_threshold +9519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IF-2 C2 β-strand motif,False,no_term_above_threshold +9520,59224,33.687374,0.9765625,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9765625,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Nucleophile-adjacent loop-helix motif,True,assigned_and_evaluated +9521,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic helical stalks,False,no_term_above_threshold +9522,85672,16.790936,0.60058594,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.60058594,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6024063234779129,0.08309667486400302,0.01595037660611431,0.05555555555555555,5.2096998657793,19.0,20.0,38.01338926174497,2.3117235620488766e-29,NTP-binding enzymes with S/T-rich tails,True,assigned_and_evaluated +9523,64317,16.347301,0.8745117,"Knottin, scorpion toxin-like superfamily",interpro,45290,Protein kinase-like domain superfamily,0.8334961,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,15.0,0.0,1.0,Generic β-sheet strand motif,True,assigned_too_few_test_positives +9524,87326,23.095219,0.64990234,Coiled coil,keyword,87326,Coiled coil,0.64990234,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6600968116422737,0.1437024097785503,0.03943287549844927,0.056179775280898875,3.6442285266313266,9.0,20.0,5.673387608373863,1.7242167518932853e-05,A/S-rich helical/disordered stalks,True,assigned_and_evaluated +9525,38654,18.95581,0.98779297,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9873047,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,16.0,0.0,1.0,Charged coiled-coil scaffolding helices,True,assigned_too_few_test_positives +9526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic alpha-helices,False,no_term_above_threshold +9527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-protein structured interaction module,False,no_term_above_threshold +9528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered β-turns,False,no_term_above_threshold +9529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Ser-rich anion-binding loops,False,no_term_above_threshold +9530,59224,17.00243,0.9296875,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7631836,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9670793650793651,0.06542008059865204,0.0031014621178555605,,21.093303130165378,2.0,14.0,19.625082290980906,0.007817957570269696,Pantothenate synthetase RPGHFDGV motif,True,assigned_and_evaluated +9531,61392,20.258028,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9996190476190476,0.9095238095238095,0.0031014621178555605,1.0,293.256462585034,18.0,18.0,167.4747191011236,5.14338702087321e-40,LRR beta-strand N-cap register,True,assigned_and_evaluated +9532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chitinase-like catalytic helical segment,False,no_term_above_threshold +9533,36914,25.302204,0.9970703,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.98876953,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,11.0,0.0,1.0,Luminal GT catalytic activation,True,assigned_too_few_test_positives +9534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular cysteine-rich ectodomains,False,no_term_above_threshold +9535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Molybdo-flavo hydroxylase PGG loop,False,no_term_above_threshold +9536,85682,18.597124,0.68896484,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.68896484,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8742741935483871,0.11842174558314872,0.011076650420912717,,10.691115191246666,0.0,16.0,0.0,1.0,Phosphate positioning SIS helix,True,assigned_and_evaluated +9537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-hydrophobic presequence detector,False,no_term_above_threshold +9538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular C-terminal accessory modules,False,no_term_above_threshold +9539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical scaffold subdomain marker,False,no_term_above_threshold +9540,36914,16.201694,0.9995117,Glycosyltransferase 2-like,interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.7861328,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,18.0,695.1694101508916,2.0253100882060637e-47,Aromatic-rich glycosyltransferase donor loop,True,assigned_too_few_test_positives +9541,87852,16.434593,0.9765625,Nucleosome core,keyword,87857,Nucleus,0.6723633,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,18.0,0.0,1.0,Charged disordered low-complexity tracts,True,assigned_too_few_test_positives +9542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CDK-phosphoregulated polybasic IDRs,False,no_term_above_threshold +9543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma factor interaction helices,False,no_term_above_threshold +9544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteolytic activation transition segments,False,no_term_above_threshold +9545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenol-donor GT-C TM helix,False,no_term_above_threshold +9546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FtsK acidic glycine rich tail,False,no_term_above_threshold +9547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal membrane-entry segment,False,no_term_above_threshold +9548,85672,33.93414,0.9472656,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9423828,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9653997198459152,0.23288617983108786,0.01595037660611431,,14.600669663299037,2.0,14.0,5.716299137104506,0.07687261802588533,Generic β-sheet signal,True,assigned_and_evaluated +9549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β–α nucleating module,False,no_term_above_threshold +9550,88161,61.61414,0.6972656,Transmembrane helix,keyword,88161,Transmembrane helix,0.6972656,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6621859034511521,0.39860547399154783,0.1847585290208241,0.3932853717026379,2.1574401793739173,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,N-terminal-biased hydrophobic TM helices,True,assigned_and_evaluated +9551,36091,18.675161,0.9785156,GNAT domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77001953,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,19.0,0.0,1.0,Hydrolase post-nucleophile helix,True,assigned_too_few_test_positives +9552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Herpesvirus Assemblin YG[D/S/A] motif,False,no_term_above_threshold +9553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Cytosolic tails, ALMT FAxWEP",False,no_term_above_threshold +9554,87277,19.285166,0.8569336,Cell outer membrane,keyword,88058,Signal,0.8461914,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.9073650793650794,0.083089196569371,0.0031014621178555605,,26.79033095101005,5.0,20.0,36.622235872235876,4.033056940996747e-07,Sec signal peptide h-region,True,assigned_and_evaluated +9555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inter-domain interface/hinge segment,False,no_term_above_threshold +9556,2772,16.989283,0.9794922,2.4.-.-,ec,63774,RNA-binding domain superfamily,0.8745117,46,ec,2.4.-.-,ec:ec:2.4.-.-,,,,,,,,3.0,16.0,136.328506097561,2.6528135968493932e-06,Hydrophobic beta-strand caps,True,assigned_too_few_test_positives +9557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal regulatory tails,False,no_term_above_threshold +9558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Clp N-terminal R-repeats,False,no_term_above_threshold +9559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-tail cap,False,no_term_above_threshold +9560,37291,20.66638,0.8540039,DnaJ domain,interpro,64599,Chaperone J-domain superfamily,0.85058594,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,0.0,17.0,0.0,1.0,Polar enzyme core loops,True,assigned_too_few_test_positives +9561,64026,19.261333,0.9501953,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.8432617,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9430253220790761,0.03155683946326623,0.002658396101019052,,11.870631111431978,0.0,13.0,0.0,1.0,Juxtamembrane helix-loop junctions,True,assigned_and_evaluated +9562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane TM boundary interfaces,False,no_term_above_threshold +9563,82029,16.365107,0.8647461,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.72265625,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix boundary motif,True,assigned_too_few_test_positives +9564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-hairpin ligand-recognition loops,False,no_term_above_threshold +9565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta group-transfer catalytic core,False,no_term_above_threshold +9566,82029,22.705551,0.9946289,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6230469,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,18.0,156.7323869610936,1.8278507282603615e-31,TM–loop helix-capping signature,True,assigned_too_few_test_positives +9567,45290,25.064306,0.9667969,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9667969,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9561737282325518,0.8605829261566965,0.0057598582188746125,0.8461538461538461,149.41043571812799,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase alphaC helix motif,True,assigned_and_evaluated +9568,49045,15.802402,0.96972656,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.93652344,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,10.0,19.0,285.267942583732,7.698460440975105e-23,C-terminal repeat capping segment,True,assigned_too_few_test_positives +9569,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma-54 EBP pre-HTH linker,False,no_term_above_threshold +9570,82029,30.45686,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,20.0,169.27097791798107,9.692152584541787e-39,Transporter cytosolic helix–loop junctions,True,assigned_too_few_test_positives +9571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix anchor motifs,False,no_term_above_threshold +9572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-loop-α phosphate-binding module,False,no_term_above_threshold +9573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered α/β core scaffolds,False,no_term_above_threshold +9574,38654,18.271744,0.9946289,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9941406,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,18.0,0.0,1.0,N-terminal interaction/targeting segments,True,assigned_too_few_test_positives +9575,46277,15.660599,0.91845703,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.91845703,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9592204322836558,0.10004240039183744,0.004873726185201595,,20.52688160767065,1.0,17.0,11.063462609018371,0.14078347170214411,Short hydrophobic β-strands,True,assigned_and_evaluated +9576,66234,16.525099,0.94433594,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.94433594,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,5.0,18.0,65.7197971781305,2.131678035724756e-08,Catalytic cysteine loop-helix motif,True,assigned_too_few_test_positives +9577,87413,52.209522,0.890625,Disulfide bond,keyword,87413,Disulfide bond,0.890625,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9315448304310675,0.6888673135576169,0.0717766947275144,0.7654320987654321,9.5973674487626,15.0,17.0,10.43577954887569,2.1080634181482354e-14,Disulfide-bonded extracellular cysteines,True,assigned_and_evaluated +9578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop capping motif,False,no_term_above_threshold +9579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane re-entrant TM motifs,False,no_term_above_threshold +9580,49061,16.543358,0.69921875,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.69921875,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8985852079728257,0.25244993400831617,0.012405848471422242,,20.34926789488463,0.0,15.0,0.0,1.0,Beta-propeller strand-loop hinges,True,assigned_and_evaluated +9581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal low-complexity segments,False,no_term_above_threshold +9582,47529,33.517773,0.97216797,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.97216797,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9662260151717982,0.72373728394631,0.007089056269384138,0.9375,102.09219061667635,17.0,17.0,77.32944228274968,2.872750145145074e-32,Proline-marked Ig/FN3 boundaries,True,assigned_and_evaluated +9583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HhH-GPD DNA N-glycosylase core,False,no_term_above_threshold +9584,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal secretion and sorting signals,False,no_term_above_threshold +9585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal fiber-interaction site,False,no_term_above_threshold +9586,27918,15.776825,0.6269531,DNA-binding transcription factor activity,go_mf,88150,Transcription regulation,0.6010742,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.6744718459834739,0.12112403165758219,0.00930438635356668,,13.01794949767443,11.0,12.0,33.92463273329195,1.5284631568396657e-16,NAC pre-core regulatory IDRs,True,assigned_and_evaluated +9587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass TM helix cores,False,no_term_above_threshold +9588,8103,17.69482,0.7241211,regulation of transcription by RNA polymerase II,go_bp,88150,Transcription regulation,0.61279297,264,go,GO:0006357,go_bp:go:GO:0006357,25.0,2257.0,0.807078853046595,0.2512292195409937,0.011076650420912717,0.08,22.68097394016091,4.0,18.0,8.063975113275173,0.0022571027143076113,S/T/P-rich nuclear regulatory IDRs,True,assigned_and_evaluated +9589,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix–loop pocket lid,False,no_term_above_threshold +9590,88164,18.605331,0.80615234,Transposition,keyword,88163,Transposable element,0.6748047,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8978241563055063,0.45377639935016983,0.002215330084182543,0.8,204.83466666666666,5.0,14.0,259.6733449477352,1.8589105316365466e-11,Integrase/Transposase Zn-finger and DDE-start,True,assigned_and_evaluated +9591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-helix boundaries and regulatory IDRs,False,no_term_above_threshold +9592,82716,18.662964,0.8535156,Laminin,gene3d,82716,Laminin,0.8535156,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,0.0,14.0,0.0,1.0,CCP/Sushi and related CRDs,True,assigned_too_few_test_positives +9593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic lid subdomain,False,no_term_above_threshold +9594,85672,17.833927,0.74316406,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7392578,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7654209815398468,0.07075931695857754,0.01595037660611431,,4.436216065986375,0.0,15.0,0.0,1.0,Sugar-nucleotide epimerase motif sensor,True,assigned_and_evaluated +9595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent pocket scaffolds,False,no_term_above_threshold +9596,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-flanking binding loops,False,no_term_above_threshold +9597,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic-aromatic binding loop motif,False,no_term_above_threshold +9598,47531,15.717747,0.9511719,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.9511719,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,1.0,16.0,15.789459745762713,0.10070383771167274,Catalytic metal-binding alpha-beta loops,True,assigned_too_few_test_positives +9599,37430,18.805065,0.96533203,"Signal transduction response regulator, receiver domain",interpro,37430,"Signal transduction response regulator, receiver domain",0.96533203,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,REC α4–β5 switch surface,True,assigned_too_few_test_positives +9600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed C-terminal regulatory tails,False,no_term_above_threshold +9601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ntn nucleophile autoprocessing signature,False,no_term_above_threshold +9602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail anchor detector,False,no_term_above_threshold +9603,63831,19.213171,0.6743164,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.6743164,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5780023693173404,0.023048663417515877,0.002658396101019052,,8.670138888888888,0.0,13.0,0.0,1.0,N-terminal domain-start marker,True,assigned_and_evaluated +9604,27013,18.684555,0.8730469,side of membrane,go_cc,87489,GPI-anchor,0.8730469,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.9647193839774916,0.04563334980902989,0.002658396101019052,,17.16574508649674,0.0,20.0,0.0,1.0,Small-residue repeat turn detector,True,assigned_and_evaluated +9605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich surface loops,False,no_term_above_threshold +9606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended soluble domains and tails,False,no_term_above_threshold +9607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CuB-binding HxxxH loop,False,no_term_above_threshold +9608,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble helical scaffolds and linkers,False,no_term_above_threshold +9609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Kinase ATP-binding P-loop,False,no_term_above_threshold +9610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly module,False,no_term_above_threshold +9611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-flanking disordered soluble segments,False,no_term_above_threshold +9612,45289,22.816887,1.0,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,1.0,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,16.0,16.0,903.3484848484848,2.5754498304135963e-47,β-sheet edge strand-cap motif,True,assigned_too_few_test_positives +9613,72011,17.786726,0.9580078,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9580078,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane helix termination motifs,True,assigned_too_few_test_positives +9614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal extramembrane stalk/tether,False,no_term_above_threshold +9615,82029,18.270912,0.93408203,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.92529297,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,NP/HP helix N-cap motifs,True,assigned_too_few_test_positives +9616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HKD-type PLD phosphodiesterase,False,no_term_above_threshold +9617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-palm loop activation,False,no_term_above_threshold +9618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nitrilase post-cysteine aromatic-glutamate motif,False,no_term_above_threshold +9619,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NACHT/AAA+ linker hotspots,False,no_term_above_threshold +9620,82029,18.396524,0.9746094,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.89746094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,17.0,11.063462609018371,0.14078347170214411,Transmembrane helix exit signature,True,assigned_too_few_test_positives +9621,64594,19.309126,0.9941406,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,88150,Transcription regulation,0.62939453,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9981102712316585,0.5521561771561772,0.003544528134692069,1.0,155.7770614801865,20.0,20.0,236.59126984126982,5.270626982754627e-47,Transcription factor activation IDRs,True,assigned_and_evaluated +9622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like NAD(P)-binding subdomain,False,no_term_above_threshold +9623,36776,21.027514,0.98828125,SANT/Myb domain,interpro,87384,DNA-binding,0.6723633,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9791203909373611,0.06683370323822635,0.002658396101019052,,25.14061136811281,0.0,18.0,0.0,1.0,Basic helix-cap nucleic-acid-binding patch,True,assigned_and_evaluated +9624,49061,25.932089,0.99853516,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99853516,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,1.0,1.0,0.012405848471422242,1.0,80.60714285714286,18.0,18.0,98.87396351575455,5.3190513750556736e-36,WD40 propeller loop residues,True,assigned_and_evaluated +9625,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature solvent-exposed protein regions,False,no_term_above_threshold +9626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA/nucleotide phosphate processing enzymes,False,no_term_above_threshold +9627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short Pro/Gly-rich strand-turn patches,False,no_term_above_threshold +9628,31094,17.30928,0.9926758,phosphopantetheine binding,go_mf,69093,"ANL, N-terminal domain",0.92089844,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9985313751668892,0.6859523809523809,0.004430660168365086,1.0,154.81945238095238,10.0,11.0,645.2489177489177,6.580567677100469e-28,Adenylation module linkers and tails,True,assigned_and_evaluated +9629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic sensor domains,False,no_term_above_threshold +9630,88153,16.480652,0.6567383,Transferase,keyword,88153,Transferase,0.6567383,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.7236697298189623,0.190278253060544,0.052724856003544526,0.025210084033613446,3.608890900484435,12.0,17.0,8.008641629820339,1.8140714767352e-09,Helical catalytic scaffold residues,True,assigned_and_evaluated +9631,30398,21.006529,0.7216797,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.65234375,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6771634420788474,0.09765663956073356,0.004873726185201595,0.09090909090909091,20.03736686259779,15.0,20.0,54.00452898550724,5.200371441495272e-24,ASCE P-loop ATPase switch,True,assigned_and_evaluated +9632,87857,18.125748,0.6298828,Nucleus,keyword,87857,Nucleus,0.6298828,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6570774510986874,0.14258301045591504,0.06247230837394772,0.04964539007092199,2.2823393943191506,13.0,17.0,4.633387135341941,1.6176219961476968e-07,Disordered acidic/mixed-charge interaction modules,True,assigned_and_evaluated +9633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipase C-terminal catalytic region,False,no_term_above_threshold +9634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral capsid structural proteins,False,no_term_above_threshold +9635,36914,23.602982,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,14.0,17.0,606.1684822076978,9.853077018652515e-38,Leloir glycosyltransferase donor-binding helix-loop,True,assigned_too_few_test_positives +9636,63960,28.907593,0.81152344,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.81152344,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,18.0,18.0,193.57467532467533,4.1657852190163465e-41,N-terminal FAD-binding subdomain,True,assigned_too_few_test_positives +9637,63774,16.403597,0.99902344,RNA-binding domain superfamily,interpro,88263,Zinc-finger,0.72265625,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,20.0,20.0,182.88650306748465,6.28875101506772e-45,Low-complexity RNA-domain boundaries,True,assigned_too_few_test_positives +9638,38873,24.00957,0.984375,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.83447266,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9984902309058614,0.6935897435897436,0.002215330084182543,0.6,313.08641025641026,10.0,10.0,171.32471264367817,1.12424031081604e-22,Conserved ABC NBD D-loop β-strand,True,assigned_and_evaluated +9639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylation machinery lumenal loops,False,no_term_above_threshold +9640,87326,21.866875,0.61376953,Coiled coil,keyword,87326,Coiled coil,0.61376953,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6531987229984659,0.24347554756483689,0.03943287549844927,0.30337078651685395,6.174430459031875,17.0,18.0,11.907109795352552,7.798097521564164e-18,Pro/Ser/Thr-rich disordered scaffolds,True,assigned_and_evaluated +9641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended C-terminal catalytic/IDR/TM regions,False,no_term_above_threshold +9642,37020,19.966396,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.87890625,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,9.0,0.0,1.0,"Small-residue beta-turns, coiled-coil heptads",True,assigned_too_few_test_positives +9643,45317,19.332514,0.9370117,"Six-bladed beta-propeller, TolB-like",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7241211,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,7.0,18.0,297.255698005698,3.7433154085055503e-16,WD40/YWTD beta-propeller signature,True,assigned_too_few_test_positives +9644,47529,28.639727,0.9916992,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9916992,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9978246318607764,0.7472939923888067,0.007089056269384138,0.875,105.41515880134604,17.0,18.0,73.03336215593025,4.719214826677225e-31,Extracellular Ig-like beta strands,True,assigned_and_evaluated +9645,38873,18.662773,0.93652344,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.79296875,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9944049733570159,0.5450861195542047,0.002215330084182543,0.4,246.05187436676803,15.0,15.0,171.32471264367817,1.0841831409947753e-33,ABC NBD switch helix,True,assigned_and_evaluated +9646,25167,18.388653,0.6479492,cell outer membrane,go_cc,25167,cell outer membrane,0.6479492,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.6648478099480326,0.21882230591246982,0.005316792202038104,0.3333333333333333,41.156828703703695,20.0,20.0,136.43249427917618,1.5446348002941576e-42,C-terminal OMBB beta-barrel signature,True,assigned_and_evaluated +9647,46082,19.342596,0.92333984,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.92333984,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9975238095238095,0.38948155019583597,0.0031014621178555605,1.0,125.57997982742883,4.0,17.0,35.51511541325391,7.960268818249041e-06,PH-like beta-hairpin motif,True,assigned_and_evaluated +9648,81858,16.107298,0.9301758,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.63964844,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,4.0,17.0,61.52837977296181,9.231908383957477e-07,Extracellular glycosylated loops,True,assigned_too_few_test_positives +9649,87149,22.991089,0.77490234,Amphibian defense peptide,keyword,87760,Membrane,0.62402344,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.80048708581683,0.06372921522780063,0.012405848471422242,,5.137029956040929,0.0,18.0,0.0,1.0,Low-complexity N-terminal IDRs,True,assigned_and_evaluated +9650,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP peptidoglycan β-lactam signature,False,no_term_above_threshold +9651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAAAR-patterned chemotaxis coiled-coils,False,no_term_above_threshold +9652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trimeric viral fiber appendages,False,no_term_above_threshold +9653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered targeting tails,False,no_term_above_threshold +9654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tailspike ICA/S74 domain,False,no_term_above_threshold +9655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycan-binding surfaces,False,no_term_above_threshold +9656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early-domain binding patch,False,no_term_above_threshold +9657,28622,18.05846,0.8466797,transposase activity,go_mf,88164,Transposition,0.796875,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.9993783303730017,0.7544444444444445,0.002215330084182543,1.0,340.55622222222223,2.0,17.0,134.8891402714932,0.00018327563975654876,Amphipathic helical/loop motifs,True,assigned_and_evaluated +9658,37312,16.44186,0.9458008,"DNA-binding HTH domain, TetR-type",interpro,43624,Homedomain-like superfamily,0.65527344,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,19.0,0.0,1.0,Conserved functional residue hotspots,True,assigned_too_few_test_positives +9659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal extramembrane regions,False,no_term_above_threshold +9660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane loop signature,False,no_term_above_threshold +9661,81858,18.389883,0.9189453,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6176758,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Cytoplasmic TM helix ends,True,assigned_too_few_test_positives +9662,37341,16.168709,0.9511719,WD40 repeat,interpro,88009,Repeat,0.6738281,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9964291645905996,0.586466268308215,0.011962782454585734,1.0,49.024235835986715,0.0,18.0,0.0,1.0,ARM/HEAT helical repeat scaffold,True,assigned_and_evaluated +9663,36115,22.889715,0.88378906,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8671875,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,13.0,0.0,1.0,Termini activation in oxygenases,True,assigned_too_few_test_positives +9664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short core amphipathic helix,False,no_term_above_threshold +9665,85672,19.583427,0.7783203,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.76416016,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.884192555905748,0.1186927591530863,0.01595037660611431,,7.441376594680994,3.0,17.0,7.061310698776156,0.013923289052854022,Active site helix caps,True,assigned_and_evaluated +9666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix caps and anchors,False,no_term_above_threshold +9667,63774,16.682205,0.9995117,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.99902344,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,16.0,16.0,182.88650306748465,2.5097298588801855e-36,RRM strand-helix junction loops,True,assigned_too_few_test_positives +9668,36776,18.260336,0.9707031,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.8330078,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9934103361468977,0.1892410951621478,0.002658396101019052,,71.1861919634946,0.0,17.0,0.0,1.0,Basic helix-entry linkers,True,assigned_and_evaluated +9669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enolate-carbanion catalysis cores,False,no_term_above_threshold +9670,36104,15.838199,0.8745117,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.86621094,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Long amphipathic coiled-coil scaffolds,True,assigned_too_few_test_positives +9671,38654,18.691126,0.88183594,B3 DNA binding domain,interpro,83267,DNA-binding pseudobarrel domain,0.8754883,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,16.0,0.0,1.0,Pre-JmjC N-terminal linker,True,assigned_too_few_test_positives +9672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured C-terminal output segments,False,no_term_above_threshold +9673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical solenoid scaffolds,False,no_term_above_threshold +9674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active-site pocket,False,no_term_above_threshold +9675,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helix-loop cap,False,no_term_above_threshold +9676,52236,21.225666,0.99072266,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9863281,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,18.0,186.08302122347067,1.3855153806489415e-32,Alpha-solenoid repeat boundary signature,True,assigned_too_few_test_positives +9677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich polyanion-binding surfaces,False,no_term_above_threshold +9678,88161,34.692932,0.68359375,Transmembrane helix,keyword,88161,Transmembrane helix,0.68359375,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7506933583567929,0.56171872118017,0.1847585290208241,0.4940047961630695,3.0402857402965076,11.0,11.0,5.4274920345926265,1.6633903518332707e-08,N-terminal signal-anchor motif,True,assigned_and_evaluated +9679,64620,17.71777,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7636719,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,15.0,15.0,324.0271739130435,8.124483338465097e-38,Bergerat-fold ATP-pocket β-strand,True,assigned_too_few_test_positives +9680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ssDNA-binding OB-folds and analogs,False,no_term_above_threshold +9681,43626,17.211319,0.9140625,Putative DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6611328,26,ip,IPR009061,interpro:ip:IPR009061,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,10.0,19.0,498.0868838763575,2.2997475247584296e-25,Helix N-cap DNA-binding patches,True,assigned_and_evaluated +9682,45324,23.683067,0.9814453,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9814453,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9994671403197158,0.6861904761904761,0.002215330084182543,1.0,309.74638095238095,9.0,17.0,289.57852131678356,1.0345399949928525e-20,Extracellular beta-solenoid domains,True,assigned_and_evaluated +9683,46079,34.649654,0.9819336,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9819336,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9944124502948032,0.6369559550555026,0.0057598582188746125,0.6923076923076923,110.58535312002073,14.0,19.0,68.64259868421053,7.594773959810474e-24,Alpha-solenoid loop-to-helix transitions,True,assigned_and_evaluated +9684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-proximal helical segments,False,no_term_above_threshold +9685,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Raptor FRNFLLAERIM helical motif,False,no_term_above_threshold +9686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Autoinhibitory N-terminal propeptides,False,no_term_above_threshold +9687,85672,23.026714,0.7988281,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7817383,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8398744309370154,0.07173843976628574,0.01595037660611431,,4.497601626458526,0.0,19.0,0.0,1.0,Helix-to-strand loops,True,assigned_and_evaluated +9688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic SP/TP-rich regulatory IDRs,False,no_term_above_threshold +9689,25169,18.541933,0.7270508,pilus,go_cc,25169,pilus,0.7270508,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8968472468916519,0.27425258982636036,0.002215330084182543,0.2,123.79761904761908,2.0,18.0,61.33847736625514,0.0008672906665695163,Outer-membrane β-barrels and appendages,True,assigned_and_evaluated +9690,47531,17.694714,0.7675781,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.7675781,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,1.0,16.0,15.789459745762713,0.10070383771167274,Active-site pocket-lining segments,True,assigned_too_few_test_positives +9691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended solvent-exposed region activation,False,no_term_above_threshold +9692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MTAP/fluorinase loop-beta-strand motif,False,no_term_above_threshold +9693,82029,35.919956,0.9902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.97802734,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS helix-end gating motifs,True,assigned_too_few_test_positives +9694,50806,18.21657,0.99609375,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.98291016,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,HTH DNA-binding helix residues,True,assigned_too_few_test_positives +9695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal maturation anchor,False,no_term_above_threshold +9696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich low-complexity repeats,False,no_term_above_threshold +9697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal nucleic acid-binding activation,False,no_term_above_threshold +9698,36104,16.855614,0.82373047,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.82373047,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Broad domain-spanning activation,True,assigned_too_few_test_positives +9699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic cofactor pocket scaffold,False,no_term_above_threshold +9700,82764,20.579935,0.9863281,Kelch-type beta propeller,gene3d,63831,F-box-like domain superfamily,0.9223633,38,gene3d,2.120.10.80,gene3d:gene3d:2.120.10.80,,,,,,,,10.0,19.0,287.8850796716562,7.013969803443412e-23,Post-F-box linker motif,True,assigned_too_few_test_positives +9701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible disordered linkers and SLiMs,False,no_term_above_threshold +9702,33778,18.794973,0.7944336,"2 iron, 2 sulfur cluster binding",go_mf,33778,"2 iron, 2 sulfur cluster binding",0.7944336,27,go,GO:0051537,go_mf:go:GO:0051537,,,,,,,,15.0,15.0,346.6337209302326,2.949183672588319e-38,Non-ligating Fe–S domain scaffold,True,assigned_too_few_test_positives +9703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide rich glycosylated ectodomains,False,no_term_above_threshold +9704,85649,18.674896,0.6308594,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.62939453,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7140632906465298,0.2625084684874741,0.0101905183872397,0.13043478260869565,25.760070146792565,11.0,11.0,110.61410018552876,8.372133250060158e-23,THUMP and MTase RNA interfaces,True,assigned_and_evaluated +9705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early IDR and signal-peptide activation,False,no_term_above_threshold +9706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed amphipathic alpha helix,False,no_term_above_threshold +9707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Assembly interfaces and regulatory linkers,False,no_term_above_threshold +9708,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory targeting signatures,False,no_term_above_threshold +9709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic scaffold and effector C-termini,False,no_term_above_threshold +9710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic/GP helix-cap linkers,False,no_term_above_threshold +9711,37071,24.48875,0.99560547,Homeodomain,interpro,43624,Homedomain-like superfamily,0.9814453,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,1.0,18.0,11.461168781237983,0.1362677695581536,HTH recognition helix cue,True,assigned_too_few_test_positives +9712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional transmembrane helix,False,no_term_above_threshold +9713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short active-site loop/helix motifs,False,no_term_above_threshold +9714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed C-terminal extensions,False,no_term_above_threshold +9715,38873,18.57484,0.92578125,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8930664,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8905417406749556,0.18249434806811857,0.002215330084182543,0.2,82.37794871794873,3.0,15.0,34.26494252873564,0.00015551355235484857,NTPase pre-Walker A segment,True,assigned_and_evaluated +9716,28225,17.950125,0.74072266,metalloendopeptidase activity,go_mf,28225,metalloendopeptidase activity,0.74072266,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,0.0,17.0,0.0,1.0,His-box intramembrane catalytic core,True,assigned_too_few_test_positives +9717,45551,15.876706,0.95703125,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.95703125,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,14.0,0.0,1.0,Helix-capping hinge loops,True,assigned_too_few_test_positives +9718,37894,15.8223,0.90234375,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.84716797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,1.0,17.0,41.75140056022409,0.039689626711981424,Rossmann glycine-rich binding loop,True,assigned_too_few_test_positives +9719,63831,20.74614,0.9448242,F-box-like domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8173828,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9609432844661632,0.036061529019208616,0.002658396101019052,,13.565145166058974,0.0,5.0,0.0,1.0,Structural helix packing anchors,True,assigned_and_evaluated +9720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Group III ADH C-terminal helix,False,no_term_above_threshold +9721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved enzyme active-site neighborhood,False,no_term_above_threshold +9722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed interaction patches,False,no_term_above_threshold +9723,87601,15.652574,0.6118164,Hydrolase,keyword,87601,Hydrolase,0.6118164,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.7219486039619405,0.13377623818333287,0.05316792202038104,0.016666666666666666,2.516108079831519,2.0,14.0,1.5976900608301845,0.5623016096261498,Acidic pocket-capping loops,True,assigned_and_evaluated +9724,49116,25.93028,0.97265625,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97265625,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9994671403197158,0.6861904761904762,0.002215330084182543,1.0,309.746380952381,17.0,17.0,87.03795620437957,3.968138690208192e-33,Acidic HEAT/ARM turns,True,assigned_and_evaluated +9725,30856,15.755547,0.72265625,transmembrane transporter activity,go_mf,30856,transmembrane transporter activity,0.72265625,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.680817051509769,0.012124652595964073,0.002215330084182543,,5.473068181818183,1.0,20.0,6.698988764044944,0.22185448440282132,Transporter C-terminal TM hairpin,True,assigned_and_evaluated +9726,36668,17.873512,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.99902344,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,15.0,15.0,532.3303571428571,4.765377825901055e-41,ANL hydrophobic helix pair,True,assigned_too_few_test_positives +9727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Contiguous ligand-binding patches,False,no_term_above_threshold +9728,87326,22.44813,0.625,Coiled coil,keyword,87326,Coiled coil,0.625,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.646935507276421,0.19446382828112282,0.03943287549844927,0.14606741573033707,4.93151528573589,9.0,18.0,6.303764009304293,5.847544268178684e-06,Amphipathic helical scaffolds,True,assigned_and_evaluated +9729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GARS C-terminal motif,False,no_term_above_threshold +9730,36104,18.693266,0.9033203,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9033203,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,9.0,0.0,1.0,Disordered regulatory tails/linkers,True,assigned_too_few_test_positives +9731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter soluble regulatory domains,False,no_term_above_threshold +9732,37020,16.042473,0.9868164,"Glycosyl transferase, family 1",interpro,85656,alpha/beta hydrolase,0.8105469,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,13.0,0.0,1.0,Kinase C-lobe N-cap motif,True,assigned_too_few_test_positives +9733,46284,24.374949,0.92089844,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.92089844,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,18.0,0.0,1.0,Short beta-strand segments,True,assigned_too_few_test_positives +9734,37020,16.601158,0.9267578,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.78027344,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,14.0,0.0,1.0,NTP-dependent nucleotidyltransferase cores,True,assigned_too_few_test_positives +9735,45714,22.97495,0.99365234,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.99365234,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,17.0,0.0,1.0,Histidine kinase ATP-lid helix,True,assigned_too_few_test_positives +9736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop phosphate-binding segment,False,no_term_above_threshold +9737,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial TM hairpins in transporters,False,no_term_above_threshold +9738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic N-terminal/TM segments,False,no_term_above_threshold +9739,85364,28.119186,0.91796875,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.91796875,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,19.0,190.1786283891547,1.9468739952274682e-25,Ligand binding cleft loops,True,assigned_too_few_test_positives +9740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domain core activation,False,no_term_above_threshold +9741,49116,23.226088,0.91503906,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.91503906,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9982238010657193,0.5315262515262515,0.002215330084182543,0.2,239.93094993894996,10.0,13.0,66.9522740033689,2.5480460661927984e-17,Phospho-regulated disordered tails,True,assigned_and_evaluated +9742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-strand microenvironment,False,no_term_above_threshold +9743,85649,20.437408,0.6611328,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6586914,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7095091666342298,0.09867957949120268,0.0101905183872397,,9.683470039636715,12.0,13.0,102.10532324818038,9.896673303892203e-24,SAM-dependent methyltransferase domains,True,assigned_and_evaluated +9744,81349,17.799267,0.96728516,1.10.287.1490,gene3d,87326,Coiled coil,0.64746094,31,gene3d,1.10.287.1490,gene3d:gene3d:1.10.287.1490,,,,,,,,4.0,16.0,89.79066265060241,2.019743521741569e-07,N-terminal coiled-coil initiation segment,True,assigned_too_few_test_positives +9745,88058,82.243774,0.8725586,Signal,keyword,88058,Signal,0.8725586,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9185064827481738,0.6924416297972866,0.09127159946832078,0.8689320388349514,7.586605623555708,18.0,20.0,6.484459214501511,1.1690409353618823e-13,Cleavable N-terminal signal peptides,True,assigned_and_evaluated +9746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking aromatic GP loops,False,no_term_above_threshold +9747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic E/Q/S-rich assembly regions,False,no_term_above_threshold +9748,31094,15.779463,0.9638672,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.81933594,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9902091677792612,0.18765529287268418,0.004430660168365086,,42.35379960136482,0.0,19.0,0.0,1.0,Secondary structure capping segments,True,assigned_and_evaluated +9749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-binding CAZyme surfaces,False,no_term_above_threshold +9750,85672,17.927364,0.72998047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7158203,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8309445194857171,0.10323608754789136,0.01595037660611431,,6.472329155433078,1.0,18.0,2.223005219985086,0.5707478730186062,Catalytic β–α junction loops,True,assigned_and_evaluated +9751,39971,17.292807,0.7397461,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,39971,"Calcineurin-like phosphoesterase domain, ApaH type",0.7397461,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,N-terminal metallo-hydrolase scaffold,True,assigned_too_few_test_positives +9752,46082,15.606453,0.98339844,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.98339844,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9992380952380953,0.8468537414965986,0.0031014621178555605,0.8571428571428571,273.04984207968903,13.0,14.0,140.15786618444847,1.7917555348233707e-27,PH helix–tail membrane patch,True,assigned_and_evaluated +9753,87326,27.608555,0.6489258,Coiled coil,keyword,87326,Coiled coil,0.6489258,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7088317301712344,0.2110066771609732,0.03943287549844927,0.056179775280898875,5.351034498340636,10.0,18.0,7.004182232560326,4.5957150021109826e-07,Eukaryotic complex assembly interfaces,True,assigned_and_evaluated +9754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-assisted phosphate catalysis,False,no_term_above_threshold +9755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral capsid scaffolding/protease,False,no_term_above_threshold +9756,64148,22.439869,0.7270508,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.72314453,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8816142232256243,0.31781733977155324,0.008418254319893664,0.15789473684210525,37.75335451917872,5.0,17.0,26.172519754170327,1.8795292639463689e-06,Long low-complexity IDRs,True,assigned_and_evaluated +9757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electropositive binding surfaces,False,no_term_above_threshold +9758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coupling helices and loops,False,no_term_above_threshold +9759,38317,16.277521,0.91845703,Pentatricopeptide repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.87109375,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9205396825396825,0.020627248133977583,0.0031014621178555605,,6.650814148341058,0.0,16.0,0.0,1.0,Active-site flanking helix caps,True,assigned_and_evaluated +9760,36535,19.455051,0.9746094,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8696289,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9963061860258122,0.8468001443001442,0.004430660168365086,0.9,191.12279256854256,13.0,13.0,89.79066265060241,1.1174852366600676e-25,Kinase C-lobe helical subdomain,True,assigned_and_evaluated +9761,38873,21.800777,0.9560547,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.91796875,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9961811722912967,0.32824016563146996,0.002215330084182543,0.6,148.16761076604556,0.0,20.0,0.0,1.0,ATPase-like N-terminal β1–loop–α1 motif,True,assigned_and_evaluated +9762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid amphipathic hairpins,False,no_term_above_threshold +9763,27733,16.644314,0.78125,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.6381836,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.9246136779416916,0.49813944338533594,0.0101905183872397,0.34782608695652173,48.8826401617697,9.0,11.0,43.94668304668305,3.185571514309334e-14,Transcriptional regulatory IDRs,True,assigned_and_evaluated +9764,36091,25.487247,0.9995117,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,19.0,19.0,377.3481012658228,1.8275710853354973e-48,GNAT N-terminal entry element,True,assigned_too_few_test_positives +9765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Molybdopterin oxidoreductase redox core,False,no_term_above_threshold +9766,87601,16.317963,0.61865234,Hydrolase,keyword,87601,Hydrolase,0.61865234,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.7377086257994072,0.16704174029796,0.05316792202038104,,3.141776732104131,8.0,14.0,6.390760243320738,1.394717944232203e-05,Catalytic phosphate binding residues,True,assigned_and_evaluated +9767,36914,22.564178,0.9428711,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.81884766,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Glycosyltransferase donor-binding loops,True,assigned_too_few_test_positives +9768,64003,22.065456,0.9970703,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.9145508,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,18.0,18.0,130.4617067833698,4.066539644609368e-38,C2H2 zinc finger knuckle,True,assigned_and_evaluated +9769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,dsRNA/small-RNA processing proteins,False,no_term_above_threshold +9770,36876,16.962318,1.0,Cytochrome P450,interpro,36876,Cytochrome P450,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,17.0,389.6797385620915,6.157114732498076e-44,P450 heme-binding Cys pocket,True,assigned_and_evaluated +9771,38873,17.40723,0.97509766,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9550781,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9957371225577264,0.40622549019607845,0.002215330084182543,0.2,183.37018627450982,13.0,16.0,139.20132902298852,1.2854920152060996e-26,AAA+ core beta-strand,True,assigned_and_evaluated +9772,88263,17.656082,0.62109375,Zinc-finger,keyword,29166,zinc ion binding,0.6044922,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.6077910398953565,0.19299278142795281,0.014621178555604785,0.18181818181818182,13.199536596451198,15.0,16.0,24.429496284965033,2.2325370481198183e-20,Acidic STP-rich chromatin IDRs,True,assigned_and_evaluated +9773,48767,17.748468,0.9736328,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9736328,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,19.0,0.0,1.0,Beta-sandwich interaction modules,True,assigned_too_few_test_positives +9774,87109,15.892471,0.74658203,ATP synthesis,keyword,87109,ATP synthesis,0.74658203,92,keywords,ATP synthesis,keyword:keywords:ATP synthesis,24.0,2257.0,0.948350500074638,0.3010227502040278,0.010633584404076208,,28.308681133770445,1.0,17.0,16.942597328786587,0.09436736101439583,N-terminal signal-anchor transmembrane helix,True,assigned_and_evaluated +9775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic beta-alpha junction motif,False,no_term_above_threshold +9776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal IDR tails,False,no_term_above_threshold +9777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic c-type cytochromes,False,no_term_above_threshold +9778,64148,28.723139,0.97021484,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.92871094,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9808922440148629,0.5381727670396563,0.008418254319893664,0.47368421052631576,63.92925974781602,13.0,19.0,60.885545954438335,2.785726983014201e-21,Helix C-cap hinge residues,True,assigned_and_evaluated +9779,36499,17.15921,0.8310547,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.8310547,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,16.0,0.0,1.0,Long C-terminal acidic IDRs,True,assigned_too_few_test_positives +9780,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-edge/loop binding segment,False,no_term_above_threshold +9781,88153,16.006638,0.60302734,Transferase,keyword,88153,Transferase,0.60302734,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.6424896431912336,0.14295481622539874,0.052724856003544526,,2.7113363043758403,0.0,18.0,0.0,1.0,P450 K-helix meander motif,True,assigned_and_evaluated +9782,64058,18.770075,0.8041992,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7285156,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9363257117381059,0.245098460230284,0.006202924235711121,0.35714285714285715,39.5133731956965,0.0,11.0,0.0,1.0,Helix-capping ligand-binding loops,True,assigned_and_evaluated +9783,28622,18.411545,0.91015625,transposase activity,go_mf,46274,Ribonuclease H-like superfamily,0.87402344,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.8954262877442274,0.4537763993501698,0.002215330084182543,0.8,204.83466666666666,2.0,13.0,176.39349112426035,0.00010614855579193059,Catalytic beta–loop–alpha junctions,True,assigned_and_evaluated +9784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site helical segments,False,no_term_above_threshold +9785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fe–S-adjacent disordered tails,False,no_term_above_threshold +9786,25169,24.94434,0.8857422,pilus,go_cc,25169,pilus,0.8857422,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8980905861456484,0.8004430660168365,0.002215330084182543,0.8,361.32,17.0,19.0,493.93615984405454,2.0314946367539277e-44,Chaperone-usher pilin Ig-like beta-strands,True,assigned_and_evaluated +9787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended C-terminal binding interface,False,no_term_above_threshold +9788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered non-catalytic activation,False,no_term_above_threshold +9789,36091,22.553888,0.99853516,GNAT domain,interpro,59224,Alpha/Beta hydrolase fold,0.91259766,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,Glycine-rich ATP-lid loop,True,assigned_too_few_test_positives +9790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short GxG-like structural motifs,False,no_term_above_threshold +9791,87239,17.5718,0.7988281,CF(1),keyword,87239,CF(1),0.7988281,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9951050514081359,0.46510351121285787,0.008861320336730172,0.85,52.486931240371014,0.0,12.0,0.0,1.0,Broad disorder-biased activation,True,assigned_and_evaluated +9792,43624,28.86529,0.9682617,Homedomain-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.95996094,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.981997434181169,0.17697215604281094,0.007089056269384138,,24.96413476178902,0.0,17.0,0.0,1.0,Nucleic acid-contacting loop residues,True,assigned_and_evaluated +9793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered low-complexity segments,False,no_term_above_threshold +9794,28225,16.679424,0.82373047,metalloendopeptidase activity,go_mf,28225,metalloendopeptidase activity,0.82373047,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,9.0,20.0,136.88494897959185,1.4939071469024417e-17,Post-HExxH S1' loop,True,assigned_too_few_test_positives +9795,49230,31.41432,0.9057617,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.9057617,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,9.0,12.0,210.92334905660377,4.3426746871524776e-20,N-terminal acyltransferase substrate interface,True,assigned_too_few_test_positives +9796,64016,47.809242,0.94873047,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.94873047,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9973333333333333,0.6737708719851576,0.0031014621178555605,0.5714285714285714,217.24297972435724,12.0,16.0,166.2295539033457,3.032460172604699e-25,Redox-adjacent α–loop–β segment,True,assigned_and_evaluated +9797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal membrane-interacting low-complexity segments,False,no_term_above_threshold +9798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved noncatalytic surface segment,False,no_term_above_threshold +9799,55053,22.416632,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,14.0,512.614417989418,7.55716403384954e-35,Acyl-thioester transfer interface,True,assigned_too_few_test_positives +9800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic Gly/Pro β/helix segment,False,no_term_above_threshold +9801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-BED mid-region peaks,False,no_term_above_threshold +9802,88134,17.856283,0.90478516,Thiol protease,keyword,88134,Thiol protease,0.90478516,93,keywords,Thiol protease,keyword:keywords:Thiol protease,16.0,2257.0,0.9670208612226685,0.8158859054486466,0.007089056269384138,0.9375,115.09090553734971,9.0,17.0,101.1668552036199,1.480101047683135e-16,Cysteine adjacent oxyanion helix,True,assigned_and_evaluated +9803,25229,16.137617,0.9589844,cytochrome b6f complex,go_cc,25079,plasma membrane,0.6020508,25,go,GO:0009512,go_cc:go:GO:0009512,5.0,2257.0,0.9759325044404972,0.0500877398438374,0.002215330084182543,,22.609605765508206,0.0,15.0,0.0,1.0,Re-entrant loops and helix breaks,True,assigned_and_evaluated +9804,63831,28.267149,0.9970703,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9970703,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9997778764993337,0.9444444444444444,0.002658396101019052,1.0,355.2685185185185,7.0,18.0,95.4154092363969,1.1596742360142641e-12,Hydrophobic aromatic interfacial helix,True,assigned_and_evaluated +9805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic CBS/RCK modules,False,no_term_above_threshold +9806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal-peptide N-terminus,False,no_term_above_threshold +9807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended hydrophobic helical segments,False,no_term_above_threshold +9808,87970,16.702229,0.7714844,Protein phosphatase,keyword,87970,Protein phosphatase,0.7714844,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,14.0,0.0,1.0,Subtilase domain-start motif,True,assigned_too_few_test_positives +9809,37282,21.823421,0.9975586,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.9902344,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,5.0,15.0,74.43320848938825,1.0178257816032659e-08,Solenoid repeat register detector,True,assigned_too_few_test_positives +9810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible charge-rich assembly scaffolds,False,no_term_above_threshold +9811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded catalytic/interaction domain cores,False,no_term_above_threshold +9812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic beta/coil edge patches,False,no_term_above_threshold +9813,63831,15.75034,0.640625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.640625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.49378054198134164,0.002658396101019052,0.002658396101019052,,1.0,0.0,17.0,0.0,1.0,Redox cofactor binding regions,True,assigned_and_evaluated +9814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylation machinery transmembrane regions,False,no_term_above_threshold +9815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UvrC GIY-YIG nuclease core,False,no_term_above_threshold +9816,88160,18.8711,0.74560547,Transmembrane beta strand,keyword,25167,cell outer membrane,0.63916016,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,17.0,221.32295830953737,5.721118510676694e-29,Outer-membrane beta-barrel domains,True,assigned_too_few_test_positives +9817,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal alpha-helical bundle detector,False,no_term_above_threshold +9818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early TM helices and caps,False,no_term_above_threshold +9819,63960,32.82059,0.9057617,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9057617,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,16.0,16.0,193.57467532467533,1.0288461071936617e-36,Flavin active site loop,True,assigned_too_few_test_positives +9820,87149,23.000994,0.7636719,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.7636719,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8685989873742228,0.14706796756385113,0.012405848471422242,,11.854728671129,0.0,12.0,0.0,1.0,Juxtamembrane/TM anchoring helices,True,assigned_and_evaluated +9821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical terpene cyclases and hydrolases,False,no_term_above_threshold +9822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HhH dsNA-binding helix,False,no_term_above_threshold +9823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core metabolic catalytic domains,False,no_term_above_threshold +9824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor/anion-binding scaffold,False,no_term_above_threshold +9825,64317,17.259909,0.89404297,"Knottin, scorpion toxin-like superfamily",interpro,64317,"Knottin, scorpion toxin-like superfamily",0.89404297,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,15.0,0.0,1.0,Charged beta-loop binding patch,True,assigned_too_few_test_positives +9826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Trp/Gly-anchored segments,False,no_term_above_threshold +9827,87856,16.235573,0.7729492,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7729492,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5601326667948472,0.026430943760720145,0.012405848471422242,,2.1305228595694774,8.0,18.0,37.6395202020202,3.07228856902525e-11,Nucleotide-engaging catalytic helices,True,assigned_and_evaluated +9828,87276,29.315516,0.6088867,Cell membrane,keyword,88161,Transmembrane helix,0.60009766,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6554370752284977,0.33742464654751547,0.11120957022596367,0.3426294820717131,3.0341331763256667,5.0,17.0,2.413375754926248,0.07791124742571386,C-terminal TM helix-tail signature,True,assigned_and_evaluated +9829,45290,23.376093,0.96728516,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.96728516,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9559851912793089,0.9235199890937594,0.0057598582188746125,0.9230769230769231,160.33727810650885,16.0,16.0,73.42487684729065,4.583656533651311e-30,Protein kinase activation loop,True,assigned_and_evaluated +9830,87108,21.915379,0.96875,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.96533203,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9626828786081455,0.05535310241567162,0.003987594151528578,,13.881328016907874,0.0,18.0,0.0,1.0,SAM-dependent MTase core helix,True,assigned_and_evaluated +9831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PPDK-family ATP-binding subdomain,False,no_term_above_threshold +9832,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HisKA DHp dimerization helices,False,no_term_above_threshold +9833,36104,27.45444,0.9814453,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9814453,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Disordered linker motif hotspots,True,assigned_too_few_test_positives +9834,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single hydrophobic transmembrane helix,False,no_term_above_threshold +9835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal oligomerization helix activation,False,no_term_above_threshold +9836,37341,28.472698,0.9941406,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99072266,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9990034877927255,0.8907494643100631,0.011962782454585734,1.0,74.4600570721412,8.0,16.0,72.70853658536585,1.298105126843334e-13,Asp-centered beta-propeller turns,True,assigned_and_evaluated +9837,59229,24.873743,0.8051758,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8051758,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.750554668950216,0.22063840710238086,0.0101905183872397,0.34782608695652173,21.65134281869885,0.0,15.0,0.0,1.0,Phosphate-binding catalytic loops,True,assigned_and_evaluated +9838,87697,26.434538,0.94091797,Knottin,keyword,87413,Disulfide bond,0.6640625,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9933816559154702,0.5335812594342819,0.017279574656623838,1.0,30.879305193414723,0.0,18.0,0.0,1.0,Extracellular cysteine-rich domains,True,assigned_and_evaluated +9839,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-repeat register hotspots,False,no_term_above_threshold +9840,46284,21.814354,0.9165039,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9165039,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,20.0,0.0,1.0,Signal transduction sensory domains,True,assigned_too_few_test_positives +9841,28025,19.914215,0.92578125,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.71484375,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9090404264771212,0.1301196613513266,0.002658396101019052,,48.94667927832402,1.0,13.0,20.846503496503498,0.07747911132020913,Pre-P-loop N-terminal leader,True,assigned_and_evaluated +9842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Linear-motif-rich adaptor IDRs,False,no_term_above_threshold +9843,85672,35.520107,0.7426758,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7200335184351394,0.3986042067375376,0.01595037660611431,0.4444444444444444,24.9902692946284,14.0,17.0,32.952783260955385,5.732262127139585e-20,Post-Walker-B helicase-nuclease element,True,assigned_and_evaluated +9844,38873,16.899044,0.9790039,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9658203,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9936944937833038,0.4877962577962578,0.002215330084182543,0.4,220.19123076923077,15.0,15.0,171.32471264367817,1.0841831409947753e-33,AAA+ ATPase motor core,True,assigned_and_evaluated +9845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal substrate-recognition lid,False,no_term_above_threshold +9846,45288,15.746109,0.9995117,CheY-like superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8901367,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,17.0,17.0,462.17829457364337,3.827449248759242e-45,REC alpha1 hydrophobic hotspot,True,assigned_too_few_test_positives +9847,38317,19.529217,0.71240234,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.71240234,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.5567619047619048,0.005405648848271799,0.0031014621178555605,,1.7429356357927785,0.0,19.0,0.0,1.0,Tyrosine recombinase core-binding HTH,True,assigned_and_evaluated +9848,63951,18.154432,0.67822266,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.6381836,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.6078489521550021,0.04013849915489259,0.003987594151528578,,10.065843621399177,8.0,19.0,67.8475106685633,3.253879641080134e-13,P/S/T-rich mucin-like linkers,True,assigned_and_evaluated +9849,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHp H-box helix,False,no_term_above_threshold +9850,85364,23.50423,0.78759766,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.78759766,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,18.0,200.74410774410774,7.313713037197334e-26,SBP Venus flytrap hinge motif,True,assigned_too_few_test_positives +9851,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cupredoxin copper-binding motif,False,no_term_above_threshold +9852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminus activation; hydrophobic helices secondary,False,no_term_above_threshold +9853,49121,15.655747,0.7739258,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.7739258,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,8.0,18.0,434.3970856102004,8.340419219713666e-20,OmpR/PhoB DBD with proline-rich linker,True,assigned_too_few_test_positives +9854,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic interface segments,False,no_term_above_threshold +9855,85672,16.18409,0.62353516,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6196289,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6368752814047726,0.10869725110566937,0.01595037660611431,0.1111111111111111,6.814713770708216,7.0,7.0,40.01409395973155,1.2993239531220957e-11,P-loop N-terminal regulatory regions,True,assigned_and_evaluated +9856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter pore-forming TM bundle,False,no_term_above_threshold +9857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse targeting and disorder signal,False,no_term_above_threshold +9858,45714,19.929972,0.7529297,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.7529297,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,14.0,0.0,1.0,HAMP coiled-coil signaling helices,True,assigned_too_few_test_positives +9859,37020,17.34921,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.97998047,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,12.0,15.0,653.3808219178082,8.823989595471275e-33,Glycosyltransferase donor-binding loop,True,assigned_too_few_test_positives +9860,55053,18.63669,0.96728516,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.96728516,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,19.0,0.0,1.0,Mixed-charge helix-start motifs,True,assigned_too_few_test_positives +9861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FHA phosphothreonine-binding hairpin,False,no_term_above_threshold +9862,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-inserting pore/fusion segments,False,no_term_above_threshold +9863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prion-like low-complexity IDRs,False,no_term_above_threshold +9864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic amphipathic gating helix,False,no_term_above_threshold +9865,85682,16.041857,0.82373047,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.82373047,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9657616487455197,0.6761289471465942,0.011076650420912717,0.76,61.04092134839452,3.0,17.0,18.04691756634043,0.0010117939322836975,Buried hydrophobic core helix,True,assigned_and_evaluated +9866,25014,17.37034,0.77734375,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.6113281,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.6432236080750933,0.055743434031099645,0.015507310589277802,,3.5946551602340544,12.0,20.0,22.109147095179235,3.6291636166427776e-14,Cytosolic disordered endomembrane tails,True,assigned_and_evaluated +9867,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP/beta-lactamase catalytic core,False,no_term_above_threshold +9868,36886,23.89548,0.9995117,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9995117,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9996665184526456,0.9085317460317461,0.003544528134692069,1.0,256.31951884920636,19.0,19.0,233.80784313725488,9.641649479262281e-45,Low-complexity TF activation IDRs,True,assigned_and_evaluated +9869,36535,19.70091,0.95654297,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.89501953,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9477303070761014,0.8525462406200109,0.004430660168365086,0.9,192.4196865079365,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase alphaF helix and linker,True,assigned_and_evaluated +9870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme catalytic and glycan-binding surfaces,False,no_term_above_threshold +9871,47531,17.754139,0.7861328,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.7861328,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,6.0,14.0,108.27058111380146,2.2679788897737096e-11,Flavin oxidoreductase C-terminal motif,True,assigned_too_few_test_positives +9872,38873,15.640401,0.70458984,AAA+ ATPase domain,interpro,38873,AAA+ ATPase domain,0.70458984,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7946714031971581,0.35821946536700633,0.002215330084182543,0.4,161.70026666666666,7.0,7.0,171.32471264367817,5.187219663614024e-16,ABC ATPase NBD core activation,True,assigned_and_evaluated +9873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro-aromatic C-terminal FAD motif,False,no_term_above_threshold +9874,63951,17.905592,0.86816406,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.82128906,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9369810201660735,0.21479297248121204,0.003987594151528578,,53.865304321121734,0.0,20.0,0.0,1.0,Extracellular solvent-exposed regions,True,assigned_and_evaluated +9875,45290,31.127386,0.97509766,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97509766,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9608185931715344,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Protein kinase activation segment,True,assigned_and_evaluated +9876,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helices,False,no_term_above_threshold +9877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic peptidoglycan glycosyltransferases,False,no_term_above_threshold +9878,61392,26.575365,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,167.4747191011236,5.14338702087321e-40,LRR β-strand core hydrophobics,True,assigned_and_evaluated +9879,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early N-terminal polar disorder,False,no_term_above_threshold +9880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FERM and juxtamembrane adaptor motif,False,no_term_above_threshold +9881,37446,18.378521,0.9584961,F-box domain,interpro,37446,F-box domain,0.9584961,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9398095238095239,0.026659729917851288,0.0031014621178555605,,8.595858632084337,0.0,11.0,0.0,1.0,Alpha-helical hydrophobic patches,True,assigned_and_evaluated +9882,83267,20.610308,0.8300781,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.8300781,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,17.0,0.0,1.0,Long luminal ectodomain loops,True,assigned_too_few_test_positives +9883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic interface hotspot,False,no_term_above_threshold +9884,39971,29.05431,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,16.0,17.0,623.4875816993464,5.26194117401153e-44,Di-metal phosphoesterase catalytic core,True,assigned_too_few_test_positives +9885,55053,15.924864,0.8359375,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.8359375,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,13.0,0.0,1.0,Terminal amphipathic capping helix,True,assigned_too_few_test_positives +9886,36104,16.329895,0.8457031,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8457031,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Noncatalytic assembly interfaces,True,assigned_too_few_test_positives +9887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic RNA/protein-binding regions,False,no_term_above_threshold +9888,38873,20.975063,0.8613281,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6689453,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9961811722912965,0.5614285714285714,0.002215330084182543,0.4,253.42885714285714,12.0,12.0,171.32471264367817,4.232415391986194e-27,ABC Walker B catalytic motif,True,assigned_and_evaluated +9889,87276,38.30864,0.6748047,Cell membrane,keyword,88161,Transmembrane helix,0.6689453,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6947106886511779,0.3659248966433505,0.11120957022596367,0.42231075697211157,3.2904083335619205,12.0,16.0,6.154108175061933,2.4137614889979377e-08,C-terminal transmembrane helix,True,assigned_and_evaluated +9890,87326,26.139122,0.6152344,Coiled coil,keyword,87326,Coiled coil,0.6152344,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6402706372569344,0.19550813856965127,0.03943287549844927,0.25842696629213485,4.957998525300033,19.0,20.0,11.977151617678155,5.677614873654298e-20,Long coiled-coil stalks,True,assigned_and_evaluated +9891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,aaRS tRNA-binding core activation,False,no_term_above_threshold +9892,85672,19.985409,0.7788086,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7729492,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8785457001350743,0.09131720174050151,0.01595037660611431,,5.725081231341997,5.0,16.0,12.504404362416107,6.198876160465875e-05,Pro-Gly capping linker loops,True,assigned_and_evaluated +9893,63960,36.872524,0.92822266,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.92822266,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,15.0,15.0,193.57467532467533,1.7387176222033654e-34,Aromatic-lined substrate channel wall,True,assigned_too_few_test_positives +9894,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal ATP-binding helical subdomain,False,no_term_above_threshold +9895,36115,20.622032,0.9116211,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9116211,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,17.0,0.0,1.0,HD/HxH phosphohydrolase active site,True,assigned_too_few_test_positives +9896,64058,20.010632,0.92529297,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7861328,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9554486975351889,0.08846118950108126,0.006202924235711121,,14.261207478852885,0.0,16.0,0.0,1.0,Beta-strand scaffold near cofactors,True,assigned_and_evaluated +9897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glyoxalase/VOC beta-strand core,False,no_term_above_threshold +9898,36104,22.01653,0.98095703,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.98095703,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Secreted prodomains and ectodomains,True,assigned_too_few_test_positives +9899,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arrestin regulatory IDR motifs,False,no_term_above_threshold +9900,63960,21.000536,0.72509766,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.72509766,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,16.0,0.0,1.0,ATP-grasp and Rossmann caps,True,assigned_too_few_test_positives +9901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclase catalytic beta-strand motif,False,no_term_above_threshold +9902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge beta-edge loops,False,no_term_above_threshold +9903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended assembly interface regions,False,no_term_above_threshold +9904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular/periplasmic loop signal,False,no_term_above_threshold +9905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed strand–loop junctions,False,no_term_above_threshold +9906,49236,17.222187,0.7836914,C-type lectin fold,interpro,49236,C-type lectin fold,0.7836914,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.6902309058614564,0.02716253138384286,0.002215330084182543,,12.261166666666668,0.0,19.0,0.0,1.0,ADP-ribosyltransferase catalytic core,True,assigned_and_evaluated +9907,38654,17.879679,0.90283203,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.8964844,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,JmjC/DSBH 2OG oxygenase fold,True,assigned_too_few_test_positives +9908,50806,17.254246,0.72802734,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.72802734,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,Amphipathic coiled-coil stalks,True,assigned_too_few_test_positives +9909,58239,16.229738,0.69970703,P-loop containing nucleoside triphosphate hydrolase,interpro,29033,ATP binding,0.6616211,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7657532701849346,0.053967137284027494,0.017722640673460344,,3.0450957212512515,1.0,16.0,2.2407170775706553,0.5681614770682746,Structured functional core strands,True,assigned_and_evaluated +9910,87149,21.799185,0.67529297,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.67529297,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6667227456258411,0.04005098809823242,0.012405848471422242,,3.2283957192039487,0.0,17.0,0.0,1.0,Glycine-zipper membrane insertion segments,True,assigned_and_evaluated +9911,85672,33.83117,0.94873047,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.94384766,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9513544949722347,0.5022058604833077,0.01595037660611431,0.3888888888888889,31.485517419745154,15.0,15.0,40.01409395973155,2.5589408230636405e-24,AAA+ Walker B beta-strand start,True,assigned_and_evaluated +9912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal domain start segment,False,no_term_above_threshold +9913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial loop–helix boundary motif,False,no_term_above_threshold +9914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conformational-control hinges and anchors,False,no_term_above_threshold +9915,85682,16.612114,0.71484375,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.71484375,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.913584229390681,0.1796290866934487,0.011076650420912717,0.04,16.21691394668455,0.0,11.0,0.0,1.0,Nucleophile-adjacent pre-catalytic loop,True,assigned_and_evaluated +9916,87413,17.56263,0.63671875,Disulfide bond,keyword,88058,Signal,0.6152344,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5444238192050445,0.07183693288021051,0.0717766947275144,,1.0008392438928093,7.0,17.0,4.870030456141989,0.0005015653316458726,Mature-chain structural residue marker,True,assigned_and_evaluated +9917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich tandem repeats,False,no_term_above_threshold +9918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta loop helix transition motifs,False,no_term_above_threshold +9919,50806,23.81419,0.96875,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.83740234,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,Helix/strand-capping hinge loops,True,assigned_too_few_test_positives +9920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase motor-domain interior,False,no_term_above_threshold +9921,48880,21.525957,0.99902344,"Pyridoxal phosphate-dependent transferase, major domain",interpro,69093,"ANL, N-terminal domain",0.95410156,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,N-terminal helix-loop-strand activation,True,assigned_too_few_test_positives +9922,88058,49.18421,0.70166016,Signal,keyword,88058,Signal,0.70166016,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.7595726451221995,0.24054551697571439,0.09127159946832078,,2.635491416573725,9.0,16.0,4.052787009063444,0.00015713841113682958,N-terminal Sec targeting helices,True,assigned_and_evaluated +9923,47529,25.155237,0.9316406,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9316406,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9487672913877733,0.2715534484424418,0.007089056269384138,0.4375,38.30600832091194,3.0,16.0,14.499270428015565,0.0018658908624807312,Long extracellular interaction regions,True,assigned_and_evaluated +9924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme terminal accessory stems,False,no_term_above_threshold +9925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBMs and propeller rim loops,False,no_term_above_threshold +9926,64026,17.596045,0.92041016,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.88183594,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9330667851325337,0.023261584567367686,0.002658396101019052,,8.750232728091477,0.0,16.0,0.0,1.0,Transmembrane helix boundary sensor,True,assigned_and_evaluated +9927,37341,24.974195,0.9790039,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97802734,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9980568011958146,0.739075855648304,0.011962782454585734,1.0,61.78126689623045,0.0,16.0,0.0,1.0,Beta-propeller rim loops,True,assigned_and_evaluated +9928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity region activation,False,no_term_above_threshold +9929,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket loop motif,False,no_term_above_threshold +9930,63831,21.440214,0.77685547,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.77685547,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.6555604916333481,0.17824285230264014,0.002658396101019052,0.16666666666666666,67.04901960784314,10.0,19.0,129.13363656053716,2.3961694245329775e-19,Noncatalytic regulatory interaction segments,True,assigned_and_evaluated +9931,85656,19.333902,0.93408203,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.82910156,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9584126984126984,0.04134971036981727,0.0031014621178555605,,13.332328043525369,0.0,15.0,0.0,1.0,Cofactor flanking beta strand anchor,True,assigned_and_evaluated +9932,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory alpha-helical bundle marker,False,no_term_above_threshold +9933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal accessory tails,False,no_term_above_threshold +9934,36091,23.664034,0.98876953,GNAT domain,interpro,85712,3.40.630.30,0.9667969,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,17.0,19.0,337.6272485009993,1.1707364615487879e-41,Acyltransferase N-terminal β–loop–α motif,True,assigned_too_few_test_positives +9935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal alpha-helical interaction region,False,no_term_above_threshold +9936,85649,17.95113,0.6484375,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.6484375,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6903974154373127,0.34085378062569793,0.0101905183872397,0.30434782608695654,33.44812969009566,12.0,15.0,88.491280148423,3.2292720064853302e-22,N-terminal SAM-binding Rossmann motif,True,assigned_and_evaluated +9937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory glycan region,False,no_term_above_threshold +9938,38317,16.417448,0.8886719,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8886719,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6659682539682539,0.008711706510990158,0.0031014621178555605,,2.808903085043541,0.0,15.0,0.0,1.0,C-terminal structural anchors,True,assigned_and_evaluated +9939,12207,18.55064,0.87597656,transposition,go_bp,88164,Transposition,0.81689453,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,0.0,17.0,0.0,1.0,Polymerase palm Mg2+-chelating scaffold,True,assigned_too_few_test_positives +9940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann phosphate-binding loop,False,no_term_above_threshold +9941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase N-domain,False,no_term_above_threshold +9942,36535,21.270546,0.95166016,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9404297,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9483088562527815,0.9004430660168364,0.004430660168365086,0.9,203.23,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase helix C-cap motif,True,assigned_and_evaluated +9943,46079,34.65019,0.9980469,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9980469,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.998868778280543,0.8898513251454425,0.0057598582188746125,0.9230769230769231,154.49188006563566,18.0,18.0,93.1578125,1.5142894056751304e-35,TPR interhelical loop residues,True,assigned_and_evaluated +9944,36449,15.791507,0.9995117,EamA domain,interpro,64026,MFS transporter superfamily,0.77001953,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,15.0,18.0,887.2172619047619,5.568290194733991e-43,Transmembrane helix exit motif,True,assigned_too_few_test_positives +9945,36449,17.993214,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,14.0,19.0,784.4868421052631,6.146287500115658e-39,Conserved transporter gating helix,True,assigned_too_few_test_positives +9946,88058,22.291286,0.6357422,Signal,keyword,88058,Signal,0.6357422,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.649031019677827,0.11669993962500239,0.09127159946832078,,1.2786007948234486,4.0,20.0,1.4409909365558913,0.4670478563492871,Disordered N-termini and coils,True,assigned_and_evaluated +9947,64016,27.027565,0.7519531,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.7421875,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7107936507936509,0.3946294069244889,0.0031014621178555605,0.42857142857142855,127.23979591836735,0.0,18.0,0.0,1.0,Heme c axial-ligation loop,True,assigned_and_evaluated +9948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic alpha-solenoid scaffolds,False,no_term_above_threshold +9949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,T2SS signal-anchor helix,False,no_term_above_threshold +9950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SusC C-terminal beta-barrel,False,no_term_above_threshold +9951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase DHp helix,False,no_term_above_threshold +9952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered helical assembly scaffold,False,no_term_above_threshold +9953,63951,18.467178,0.7314453,Immunoglobulin-like domain superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.7314453,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9394523527085804,0.29718017309877115,0.003987594151528578,0.2222222222222222,74.52618340932517,0.0,11.0,0.0,1.0,Cupredoxin-like extracellular copper sites,True,assigned_and_evaluated +9954,87384,18.738577,0.66259766,DNA-binding,keyword,87384,DNA-binding,0.66259766,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.6473001563363009,0.0622675896873434,0.043863535666814356,,1.4195752517609501,4.0,20.0,2.4500102732689544,0.1221991961861518,"Coiled-coils, collagen, sigma54 HTH",True,assigned_and_evaluated +9955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic alpha/beta active-site barrels,False,no_term_above_threshold +9956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical scaffolds with charged tails,False,no_term_above_threshold +9957,64016,40.084988,0.8691406,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.8691406,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.997968253968254,0.7971428571428572,0.0031014621178555605,0.7142857142857143,257.0216326530612,12.0,16.0,166.2295539033457,3.032460172604699e-25,N-terminal redox-domain boundary detector,True,assigned_and_evaluated +9958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helix-loop interfaces,False,no_term_above_threshold +9959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VOC metalloenzyme fold detector,False,no_term_above_threshold +9960,47529,21.34242,0.95166016,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.95166016,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.981997434181169,0.2232146057531935,0.007089056269384138,,31.48721032405986,3.0,16.0,14.499270428015565,0.0018658908624807312,Short coil/turn junctions,True,assigned_and_evaluated +9961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTPase–effector coupling segment,False,no_term_above_threshold +9962,87384,16.963205,0.63671875,DNA-binding,keyword,87384,DNA-binding,0.63671875,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.5175948549442525,0.041556680444294745,0.043863535666814356,,0.9474083612401337,2.0,20.0,1.2250051366344772,0.7675321987297693,S/T/P-rich disordered regulatory tails,True,assigned_and_evaluated +9963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-beta junction edge strand,False,no_term_above_threshold +9964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repetitive modules and transmembrane helices,False,no_term_above_threshold +9965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered polybasic C-terminal tails,False,no_term_above_threshold +9966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmannoid mid-domain beta-alpha motif,False,no_term_above_threshold +9967,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domain cores and propellers,False,no_term_above_threshold +9968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal regulatory tails,False,no_term_above_threshold +9969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site rim substrate-binding subdomains,False,no_term_above_threshold +9970,64003,16.521364,0.70947266,Zinc finger C2H2 superfamily,interpro,84427,Classic Zinc Finger,0.7011719,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.826067615658363,0.22373642045773193,0.003987594151528578,0.1111111111111111,56.10812233034456,0.0,16.0,0.0,1.0,S/T-rich beta-solenoid loop motif,True,assigned_and_evaluated +9971,64148,20.883003,0.6958008,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6772461,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.591987676967217,0.07895368256023994,0.008418254319893664,0.05263157894736842,9.378866396761135,17.0,17.0,88.9865671641791,2.741613493532558e-33,N-terminal pre-HTH support helix,True,assigned_and_evaluated +9972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic recognition modules,False,no_term_above_threshold +9973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH20/GH84 sugar-binding loop motif,False,no_term_above_threshold +9974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Contiguous bioactive effector segments,False,no_term_above_threshold +9975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory beta-strand/loop patches,False,no_term_above_threshold +9976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS N-terminal helix motif,False,no_term_above_threshold +9977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAL c-di-GMP phosphodiesterase domain,False,no_term_above_threshold +9978,82029,30.583807,0.9897461,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.97753906,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS central-cavity TM2/TM8 helices,True,assigned_too_few_test_positives +9979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosidase substrate-binding cleft,False,no_term_above_threshold +9980,58239,30.229797,0.87402344,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.87402344,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.9235227785295443,0.2941314850892672,0.017722640673460344,0.025,16.5963690461619,13.0,13.0,35.851473241130485,1.5607041751034244e-20,Phosphate-binding loop-adjacent coils,True,assigned_and_evaluated +9981,46079,37.23295,0.9902344,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9902344,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9997257644316467,0.9671597633136091,0.0057598582188746125,1.0,167.91381429221659,18.0,18.0,93.1578125,1.5142894056751304e-35,TPR/SEL1 helical repeat scaffold,True,assigned_and_evaluated +9982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic regulatory tails,False,no_term_above_threshold +9983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C catalytic helix/loop,False,no_term_above_threshold +9984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich coiled-coil tails,False,no_term_above_threshold +9985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Base-flipping DNA recognition surfaces,False,no_term_above_threshold +9986,59229,16.30257,0.81152344,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,88153,Transferase,0.6279297,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.866169086450508,0.09921354090156526,0.0101905183872397,,9.735867904992729,0.0,18.0,0.0,1.0,Helix C-cap alpha-beta connector,True,assigned_and_evaluated +9987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered chromatin regulatory linkers,False,no_term_above_threshold +9988,88161,43.359413,0.64160156,Transmembrane helix,keyword,88161,Transmembrane helix,0.64160156,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7224168491293922,0.4842532300825221,0.1847585290208241,0.539568345323741,2.6210060918375357,15.0,17.0,4.78896355993467,1.8200329607237112e-09,Extracytoplasmic assembly linker motif,True,assigned_and_evaluated +9989,84152,20.355892,0.98583984,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.98583984,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,1.0,17.0,33.08601553829079,0.0496339637689314,Active-site β–α gating loops,True,assigned_too_few_test_positives +9990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta strands,False,no_term_above_threshold +9991,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix-to-coil caps,False,no_term_above_threshold +9992,86130,16.898926,0.9355469,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.88183594,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9315555555555555,0.02353232308211864,0.0031014621178555605,,7.58749331376311,0.0,18.0,0.0,1.0,Hydrophobic beta-sheet core,True,assigned_and_evaluated +9993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C membrane glycosyltransferases,False,no_term_above_threshold +9994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid PPI scaffolds,False,no_term_above_threshold +9995,37446,15.763604,0.8774414,F-box domain,interpro,88153,Transferase,0.66552734,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.8093968253968254,0.008657510730181027,0.0031014621178555605,,2.791428816859797,0.0,19.0,0.0,1.0,Catalytic-domain alpha-helix signal,True,assigned_and_evaluated +9996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded functional domain cores,False,no_term_above_threshold +9997,87326,26.387867,0.7133789,Coiled coil,keyword,87326,Coiled coil,0.7133789,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7434232347941458,0.22412434148851237,0.03943287549844927,0.14606741573033707,5.683692570107556,9.0,17.0,6.674573656910428,3.1772786071036616e-06,Short charged helix-adjacent motif,True,assigned_and_evaluated +9998,88058,52.83358,0.828125,Signal,keyword,88058,Signal,0.828125,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8350981997888787,0.32248732056702545,0.09127159946832078,0.019417475728155338,3.5332712743678467,8.0,20.0,2.8819818731117826,0.0062651088960540115,Weak N+3 positional cue,True,assigned_and_evaluated +9999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand-rich assembly interfaces,False,no_term_above_threshold +10000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic low-complexity tails,False,no_term_above_threshold +10001,36535,21.257895,0.953125,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9526367,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9484868713840676,0.8668319549057254,0.004430660168365086,0.9,195.64397222222223,15.0,15.0,89.79066265060241,1.585928718533337e-29,Kinase αF G…Y/T motif,True,assigned_and_evaluated +10002,46933,16.020306,0.95458984,"Zinc finger, NHR/GATA-type",interpro,88261,Zinc,0.7055664,49,ip,IPR013088,interpro:ip:IPR013088,,,,,,,,0.0,16.0,0.0,1.0,ZZ-type zinc finger domain,True,assigned_too_few_test_positives +10003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic pore-lining segments,False,no_term_above_threshold +10004,29034,19.817556,0.77001953,GTP binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.71191406,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.7436298614215466,0.4603523773400823,0.008861320336730172,0.45,51.95076578282829,14.0,14.0,129.6108695652174,8.124058898433896e-30,GTPase Switch I effector interface,True,assigned_and_evaluated +10005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-gating surface loops,False,no_term_above_threshold +10006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme core alpha-helices,False,no_term_above_threshold +10007,38873,17.909504,0.94140625,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8774414,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9929840142095915,0.4820551378446115,0.002215330084182543,0.4,217.59968922305765,10.0,11.0,155.74973876698013,1.1974008580911447e-21,AAA+ Sensor-II helix,True,assigned_and_evaluated +10008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like acidic IDRs,False,no_term_above_threshold +10009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain core pocket activation,False,no_term_above_threshold +10010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic PRR signaling domains,False,no_term_above_threshold +10011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal RWD-like cap domains,False,no_term_above_threshold +10012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine rich TBDR loops,False,no_term_above_threshold +10013,50806,28.87189,0.95751953,"Homeobox, conserved site",interpro,37071,Homeodomain,0.8798828,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,18.0,0.0,1.0,Transferase transmembrane anchor helix,True,assigned_too_few_test_positives +10014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal glycan-assembly anchors,False,no_term_above_threshold +10015,82029,27.000923,0.9995117,MFS general substrate transporter like domains,gene3d,88162,Transport,0.60546875,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,MFS TM5/TM11 glycine hinges,True,assigned_too_few_test_positives +10016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic globular domain detector,False,no_term_above_threshold +10017,88058,33.311043,0.6176758,Signal,keyword,88058,Signal,0.6176758,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6284194780665837,0.21971791370938937,0.09127159946832078,0.12135922330097088,2.407297724476174,11.0,17.0,4.662029500622001,3.828854493272791e-06,Conserved catalytic domain loop motif,True,assigned_and_evaluated +10018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic α-helical segments,False,no_term_above_threshold +10019,85649,20.540354,0.95996094,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.95751953,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9230761745358296,0.6497370936261408,0.0101905183872397,0.6521739130434783,63.75898349192173,13.0,13.0,110.61410018552876,7.552885156667182e-27,Class I SAM MTase helices,True,assigned_and_evaluated +10020,29034,16.490925,0.64746094,GTP binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.63720703,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.6214573088958426,0.08426503787159526,0.008861320336730172,,9.509309523809526,10.0,12.0,108.0090579710145,1.1368825609785532e-19,P-loop NTPase switch loops,True,assigned_and_evaluated +10021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leucine-rich amphipathic interface helix,False,no_term_above_threshold +10022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site flanking helix,False,no_term_above_threshold +10023,64507,34.297832,0.9951172,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9951172,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9998517200474496,0.9722222222222223,0.003987594151528578,1.0,243.81172839506178,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat C-terminal turn motif,True,assigned_and_evaluated +10024,64058,19.753162,0.6513672,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.63916016,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6391631106298962,0.2758592315969365,0.006202924235711121,0.2857142857142857,44.47244897959183,11.0,16.0,78.37368546845124,2.287171325061513e-19,Rossmann-like NAD(P) cofactor-binding subdomain,True,assigned_and_evaluated +10025,85656,16.721123,0.8979492,alpha/beta hydrolase,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.77978516,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9657460317460317,0.07944115243965318,0.0031014621178555605,,25.614097293756746,0.0,16.0,0.0,1.0,Sparse noncatalytic loop/turn residues,True,assigned_and_evaluated +10026,27936,21.652454,0.8354492,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.8354492,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,8.0,8.0,641.0860215053764,7.251916484533769e-23,PPIase catalytic loop detector,True,assigned_too_few_test_positives +10027,84152,16.860453,0.8930664,Metal-dependent hydrolases,gene3d,47531,Aldolase-type TIM barrel,0.85302734,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,13.0,0.0,1.0,Glycine-rich beta-alpha gating loops,True,assigned_too_few_test_positives +10028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse noncontiguous disordered activations,False,no_term_above_threshold +10029,82029,30.658752,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS TM-adjacent short helices,True,assigned_too_few_test_positives +10030,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic C-terminal appendages,False,no_term_above_threshold +10031,39971,26.841198,0.9614258,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9550781,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,4.0,14.0,189.27301587301588,9.743175680265408e-09,Noncatalytic phosphoesterase interfaces,True,assigned_too_few_test_positives +10032,47529,18.338118,0.74658203,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.74658203,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6739736724676484,0.06886934537852432,0.007089056269384138,,9.714882032458087,2.0,18.0,8.592160253638852,0.03740996961272103,Lumenal and adaptin C-terminal peak,True,assigned_and_evaluated +10033,64596,33.053303,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,13.0,13.0,614.6494845360825,1.4173313179671264e-36,Pre-active-site rim segment,True,assigned_too_few_test_positives +10034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic mature domain activation,False,no_term_above_threshold +10035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenosine cofactor-binding cores,False,no_term_above_threshold +10036,45290,17.57446,0.8701172,Protein kinase-like domain superfamily,interpro,43624,Homedomain-like superfamily,0.8354492,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9573906485671191,0.24773817613866075,0.0057598582188746125,0.07692307692307693,43.011158734227486,0.0,12.0,0.0,1.0,Recognition/catalytic helical residues,True,assigned_and_evaluated +10037,37446,16.728043,0.9199219,F-box domain,interpro,37446,F-box domain,0.9199219,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9436190476190476,0.030375544202188333,0.0031014621178555605,,9.79394332347701,0.0,16.0,0.0,1.0,Alpha-helix capping residues,True,assigned_and_evaluated +10038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular/periplasmic vestibule domains,False,no_term_above_threshold +10039,82029,23.330254,0.99072266,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6147461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,11.0,17.0,121.69808869920209,2.6128261465249547e-21,Transmembrane helix core signature,True,assigned_too_few_test_positives +10040,87276,33.230736,0.62841797,Cell membrane,keyword,88161,Transmembrane helix,0.60595703,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.722735180911449,0.4883707489233504,0.11120957022596367,0.4820717131474104,4.391445339920326,3.0,14.0,1.7583166214462662,0.37555500907425426,Juxtamembrane N-terminal amphipathic helix,True,assigned_and_evaluated +10041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured assembly interface domains,False,no_term_above_threshold +10042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic nucleotide-pocket scaffolds,False,no_term_above_threshold +10043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme sugar-binding cleft loops,False,no_term_above_threshold +10044,87489,18.617275,0.7558594,GPI-anchor,keyword,87489,GPI-anchor,0.7558594,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.7570793650793651,0.02438055650691285,0.0031014621178555605,,7.860988005157472,0.0,17.0,0.0,1.0,S/T/G/P-rich disordered linkers,True,assigned_and_evaluated +10045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix core/cap detector,False,no_term_above_threshold +10046,85656,24.151144,0.9501953,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.94628906,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9842857142857143,0.09771932619414164,0.0031014621178555605,,31.507502745739668,0.0,17.0,0.0,1.0,Sugar-nucleotide binding helix/loop,True,assigned_and_evaluated +10047,49236,18.998203,0.9614258,C-type lectin fold,interpro,49236,C-type lectin fold,0.9614258,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,16.0,16.0,542.0090909090909,9.368724934240899e-44,Disulfide-stabilized extracellular recognition modules,True,assigned_and_evaluated +10048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic hydrophobic transmembrane helices,False,no_term_above_threshold +10049,36104,17.967955,0.9916992,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9916992,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,C-terminal assembly interface helices,True,assigned_too_few_test_positives +10050,87108,27.650827,0.9838867,ANK repeat,keyword,88009,Repeat,0.6635742,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9946866350336101,0.2711076686566883,0.003987594151528578,,67.98777868423839,0.0,19.0,0.0,1.0,HEAT/ARM concave register detector,True,assigned_and_evaluated +10051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β-loop-α pocket cap,False,no_term_above_threshold +10052,6543,16.476437,0.77441406,NADH:ubiquinone reductase (H+-translocating),ec,88161,Transmembrane helix,0.609375,41,ec,7.1.1.2,ec:ec:7.1.1.2,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix end interface,True,assigned_too_few_test_positives +10053,82029,18.254333,0.96435547,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.88378906,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,12.0,0.0,1.0,Aromatic rich transmembrane helices,True,assigned_too_few_test_positives +10054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble extracytoplasmic scaffold domains,False,no_term_above_threshold +10055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic β-strand register motif,False,no_term_above_threshold +10056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-rich anchoring loop,False,no_term_above_threshold +10057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil signaling linkers,False,no_term_above_threshold +10058,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic transmembrane helix cores,False,no_term_above_threshold +10059,39958,19.94457,0.8769531,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8769531,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9986672589960017,0.5021825396825397,0.002658396101019052,1.0,188.904332010582,0.0,10.0,0.0,1.0,Coiled-coil heptad stripe,True,assigned_and_evaluated +10060,82107,17.866697,0.72265625,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.7216797,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,13.0,0.0,1.0,NLR/STAND effector-core signature,True,assigned_too_few_test_positives +10061,38878,17.281338,0.9975586,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.84033203,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,14.0,14.0,223.29962546816478,4.209778812622797e-33,Ig-like module and linker detector,True,assigned_too_few_test_positives +10062,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed low-complexity loops,False,no_term_above_threshold +10063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge fold nucleators,False,no_term_above_threshold +10064,47529,27.037762,0.94873047,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.94873047,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9807842481035253,0.31250984594925124,0.007089056269384138,0.1875,44.083420144216255,6.0,19.0,24.419823878763054,2.1182407366418683e-07,Immunoglobulin-like beta-strand motif,True,assigned_and_evaluated +10065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal lid/propeptide activation,False,no_term_above_threshold +10066,36104,15.882643,0.97265625,Rho GTPase-activating protein domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.91503906,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Helical oligomerization interfaces,True,assigned_too_few_test_positives +10067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long acidic cytosolic linkers,False,no_term_above_threshold +10068,58239,34.803905,0.7685547,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7685547,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7603743797925124,0.2318763890409217,0.017722640673460344,0.1,13.083625251634007,15.0,16.0,33.61075616355983,1.95430617609731e-22,Targeting peptides and active sites,True,assigned_and_evaluated +10069,63831,29.384775,0.9609375,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9609375,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9992595883311121,0.7402777777777777,0.002658396101019052,1.0,278.46782407407403,15.0,18.0,204.46159122085052,3.395286961101903e-33,E3 ligase substrate receptors,True,assigned_and_evaluated +10070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β–α helix N-cap pocket rims,False,no_term_above_threshold +10071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered DNA-contact segments,False,no_term_above_threshold +10072,85649,29.99172,0.9790039,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9760742,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.904013078509984,0.6709233115076183,0.0101905183872397,0.782608695652174,65.8379962640302,15.0,15.0,110.61410018552876,7.1622047874657735e-31,SAM-binding motif III strand-turn,True,assigned_and_evaluated +10073,37894,17.13348,0.9819336,Short-chain dehydrogenase/reductase SDR,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96240234,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,1.0,19.0,37.356516290726816,0.044180464377624094,Rossmann adenosine binding pocket,True,assigned_too_few_test_positives +10074,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Global activation, binding-adjacent loops",False,no_term_above_threshold +10075,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix caps and hinges,False,no_term_above_threshold +10076,82029,26.071234,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,Membrane transporter helix interfaces,True,assigned_too_few_test_positives +10077,87852,17.057987,0.9135742,Nucleosome core,keyword,87857,Nucleus,0.6542969,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,20.0,0.0,1.0,RS/SR phospho-regulated IDRs,True,assigned_too_few_test_positives +10078,50806,25.149904,0.98046875,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9169922,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,11.0,0.0,1.0,HTH C-terminal cap/tail,True,assigned_too_few_test_positives +10079,49230,16.220964,0.7783203,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.7783203,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,16.0,0.0,1.0,Strand-loop docking patches,True,assigned_too_few_test_positives +10080,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-loop-α phosphate-binding cradle,False,no_term_above_threshold +10081,72011,15.869776,0.9550781,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8510742,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Rossmann helix–loop–β junction,True,assigned_too_few_test_positives +10082,87326,16.42316,0.6166992,Coiled coil,keyword,24917,nucleus,0.6123047,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6580937227911606,0.1693121831767168,0.03943287549844927,0.1348314606741573,4.293680869998313,11.0,19.0,7.299095168668129,6.365830407590611e-08,Charge-rich alpha-helical scaffolds,True,assigned_and_evaluated +10083,48767,17.543783,0.9995117,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9995117,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,2.0,20.0,93.15781249999999,0.0003839531918790741,Structured-to-coil boundary segments,True,assigned_too_few_test_positives +10084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic aromatic interface helix,False,no_term_above_threshold +10085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM luminal ectodomains,False,no_term_above_threshold +10086,49045,17.719416,0.99853516,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8955078,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,18.0,18.0,542.0090909090909,9.077238758683182e-49,Beta-propeller GH loop motifs,True,assigned_too_few_test_positives +10087,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane beta-barrel turns,False,no_term_above_threshold +10088,36409,20.994291,0.96484375,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.96484375,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,16.0,0.0,1.0,Aromatic hydrophobics at helix termini,True,assigned_too_few_test_positives +10089,48880,18.322842,0.93847656,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.93847656,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,9.0,9.0,484.7235772357723,1.4957023623077688e-24,N-terminal PLP active-site gate,True,assigned_too_few_test_positives +10090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA-like P-loop NTPase core,False,no_term_above_threshold +10091,29679,15.881833,0.7753906,FMN binding,go_mf,29679,FMN binding,0.7753906,25,go,GO:0010181,go_mf:go:GO:0010181,,,,,,,,6.0,13.0,259.5979680696662,1.05535586842818e-13,N-terminal β1-α1 phosphate loop,True,assigned_too_few_test_positives +10092,6543,22.589682,0.87158203,NADH:ubiquinone reductase (H+-translocating),ec,29104,NADH dehydrogenase (ubiquinone) activity,0.87109375,41,ec,7.1.1.2,ec:ec:7.1.1.2,,,,,,,,0.0,11.0,0.0,1.0,Energy-transducing TM helices and loops,True,assigned_too_few_test_positives +10093,37314,16.46266,0.72509766,"Helicase, C-terminal domain-like",interpro,37314,"Helicase, C-terminal domain-like",0.72509766,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,0.0,17.0,0.0,1.0,GT-C oligosaccharyltransferases,True,assigned_too_few_test_positives +10094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet pocket edges,False,no_term_above_threshold +10095,46581,23.533722,0.73291016,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.73291016,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,0.0,20.0,0.0,1.0,Solvent-exposed beta-strand motif,True,assigned_too_few_test_positives +10096,36535,18.53986,0.9682617,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.95996094,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9475967957276369,0.8904430660168365,0.004430660168365086,0.9,200.973,17.0,17.0,89.79066265060241,2.357720211227094e-33,Kinase APE/P+1 helix-coil junction,True,assigned_and_evaluated +10097,37314,16.56462,0.9970703,"Helicase, C-terminal domain-like",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.66796875,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,13.0,14.0,294.480623100304,1.1620666043554925e-31,RecA2 strand-helix coupling motif,True,assigned_too_few_test_positives +10098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic/mixed-charge IDRs,False,no_term_above_threshold +10099,85664,22.680346,0.98095703,Glycogen Phosphorylase B;,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.89697266,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,Glycosyltransferase proline-anchored strand-loop motif,True,assigned_too_few_test_positives +10100,59237,19.980284,0.8496094,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.8496094,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,0.0,18.0,0.0,1.0,LysM cell-wall binding modules,True,assigned_too_few_test_positives +10101,72011,18.005415,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9472656,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,14.0,15.0,550.9531353135314,6.322218750987037e-38,ANL C-terminal acceptor-docking helix,True,assigned_too_few_test_positives +10102,87149,23.311962,0.7426758,Amphibian defense peptide,keyword,87162,Antimicrobial,0.68115234,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7952797538934819,0.10722328108936788,0.012405848471422242,,8.642962336382261,0.0,20.0,0.0,1.0,Glycine-rich membrane insertion segments,True,assigned_and_evaluated +10103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic N-terminal cap,False,no_term_above_threshold +10104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal low-complexity linkers,False,no_term_above_threshold +10105,85762,29.828821,0.80371094,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.78759766,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,14.0,14.0,205.58965517241379,1.3323113268805393e-32,Flavin cofactor binding pocket,True,assigned_too_few_test_positives +10106,49045,19.402554,0.99902344,Kelch-type beta propeller,interpro,49045,Kelch-type beta propeller,0.99902344,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,18.0,19.0,513.4822966507177,1.1421535230573433e-47,Beta-propeller blade loops,True,assigned_too_few_test_positives +10107,39971,17.016685,0.98095703,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9794922,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,PAS/PAC β-strands and junction,True,assigned_too_few_test_positives +10108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge helical scaffolds,False,no_term_above_threshold +10109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,uL22 GxxGRWP Arg motif,False,no_term_above_threshold +10110,87914,16.109352,0.6533203,Phosphoprotein,keyword,87857,Nucleus,0.6503906,957,keywords,Phosphoprotein,keyword:keywords:Phosphoprotein,84.0,2257.0,0.677179891745009,0.09774192312857487,0.03721754541426672,0.023809523809523808,2.62623238691897,12.0,14.0,5.222658588218118,4.954522278463337e-08,Compositionally biased disordered tails,True,assigned_and_evaluated +10111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured catalytic binding cores,False,no_term_above_threshold +10112,59218,15.744461,0.6875,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.6875,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,9.0,17.0,294.9912039582188,8.738953048769942e-21,Active-site peripheral loops,True,assigned_too_few_test_positives +10113,88160,16.517805,0.84472656,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.84472656,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,10.0,15.0,192.9482200647249,1.5566637929229431e-21,Outer-membrane beta-barrel strands,True,assigned_too_few_test_positives +10114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich low-complexity IDRs,False,no_term_above_threshold +10115,69819,19.250696,0.8574219,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8261719,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,0.0,17.0,0.0,1.0,Active-site N-terminal helical cap,True,assigned_too_few_test_positives +10116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity C-termini,False,no_term_above_threshold +10117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse low-complexity/disorder signature,False,no_term_above_threshold +10118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic loop-helix junction motif,False,no_term_above_threshold +10119,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich helix-capping loops,False,no_term_above_threshold +10120,50869,19.898594,0.94433594,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.94433594,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,3.0,19.0,144.82834008097163,2.2708705518560316e-06,Cytosolic nucleotide-binding catalytic cores,True,assigned_too_few_test_positives +10121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-proximal basic-acidic loop,False,no_term_above_threshold +10122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidase/deaminase active sites,False,no_term_above_threshold +10123,47529,32.849598,0.9584961,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9584961,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9934460062472111,0.48146780621457563,0.007089056269384138,0.4375,67.91705241414358,16.0,20.0,61.86355382619975,7.825300483517161e-27,PKD His-x-Tyr motif,True,assigned_and_evaluated +10124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain core activation,False,no_term_above_threshold +10125,30398,17.116476,0.6855469,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.6303711,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6764348741196471,0.23247856649495993,0.004873726185201595,0.18181818181818182,47.7003749617386,11.0,11.0,72.00603864734299,9.221343737889677e-21,ABC NBD D-loop coupling,True,assigned_and_evaluated +10126,29034,18.771297,0.7607422,GTP binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.71435547,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.7134108180599017,0.19967288535936079,0.008861320336730172,0.45,22.533085112803867,0.0,12.0,0.0,1.0,Nucleotide-pocket β-strand/loop,True,assigned_and_evaluated +10127,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP transpeptidase catalytic motif,False,no_term_above_threshold +10128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal effector-binding oligomerization domains,False,no_term_above_threshold +10129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal periplasmic OmpA-like PG-binding,False,no_term_above_threshold +10130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16 metalloprotease mid-region,False,no_term_above_threshold +10131,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved aromatic packing hotspots,False,no_term_above_threshold +10132,49236,16.92447,0.80615234,C-type lectin fold,interpro,49236,C-type lectin fold,0.80615234,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.7929840142095915,0.07832202946957045,0.002215330084182543,,35.354564102564105,2.0,14.0,77.42987012987012,0.0005420595021031187,Papain-like cysteine protease core,True,assigned_and_evaluated +10133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic N-terminal membrane-proximal domains,False,no_term_above_threshold +10134,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic nucleic-acid compaction segments,False,no_term_above_threshold +10135,38873,17.025316,0.9873047,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95410156,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9986678507992895,0.7655555555555555,0.002215330084182543,0.8,345.5717777777778,15.0,19.0,135.25635208711435,3.33799764294332e-30,Walker A P-loop glycine detector,True,assigned_and_evaluated +10136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-binding beta-hairpins,False,no_term_above_threshold +10137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion groove-lining segments,False,no_term_above_threshold +10138,37894,22.726517,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8378906,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,8.0,709.7738095238095,3.1343957826349425e-23,Rossmann β1–α1 NAD(P)+-binding loop,True,assigned_too_few_test_positives +10139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed loops and IDRs,False,no_term_above_threshold +10140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M24 aminopeptidase-like fold,False,no_term_above_threshold +10141,37071,22.808548,0.95410156,Homeodomain,interpro,80926,Homeodomain-like,0.9160156,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,6.0,19.0,65.14769623019485,6.582408576042793e-10,N-terminal dimerization/acidic regions,True,assigned_too_few_test_positives +10142,87601,16.109562,0.6381836,Hydrolase,keyword,87601,Hydrolase,0.6381836,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.5971962252378723,0.07365885400928837,0.05316792202038104,,1.3854002791580322,1.0,10.0,1.1183830425811292,0.9405729282480451,Transsulfuration N-terminal P[IVL][Y/F] motif,True,assigned_and_evaluated +10143,50806,24.874575,0.9975586,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9111328,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,18.0,0.0,1.0,HTH recognition helix turn,True,assigned_too_few_test_positives +10144,85664,17.081173,0.98046875,Glycogen Phosphorylase B;,gene3d,88153,Transferase,0.6303711,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Glycosyltransferase catalytic core motif,True,assigned_too_few_test_positives +10145,85672,28.599522,0.9067383,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.89501953,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9097503626994848,0.16173365967306577,0.01595037660611431,,10.139801941169708,14.0,14.0,40.01409395973155,9.778128717856954e-23,RecA-like ATPase H-loop histidine,True,assigned_and_evaluated +10146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-strand-rich cores,False,no_term_above_threshold +10147,55053,15.731915,0.7919922,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.7919922,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,16.0,0.0,1.0,GST-like H-site recognition,True,assigned_too_few_test_positives +10148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic allosteric tails and helices,False,no_term_above_threshold +10149,36668,22.866789,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.99853516,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,18.0,18.0,532.3303571428571,1.2239400872533205e-48,ANL N-terminal Tyr-centered motif,True,assigned_too_few_test_positives +10150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface helix-edge hydrophobic motifs,False,no_term_above_threshold +10151,29034,20.121855,0.68652344,GTP binding,go_mf,29034,GTP binding,0.68652344,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.6700379973178363,0.185417499052986,0.008861320336730172,0.25,20.92436476812947,11.0,11.0,129.6108695652174,1.4750276155839657e-23,GTPase-adjacent helical effector regions,True,assigned_and_evaluated +10152,64026,18.95092,0.88916016,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.71972656,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.843699096697764,0.014337588711085654,0.002658396101019052,,5.39332295348672,0.0,16.0,0.0,1.0,Transmembrane helix exit motif,True,assigned_and_evaluated +10153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleoside hydrolase catalytic helix activation,False,no_term_above_threshold +10154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal hydrophobic motif detector,False,no_term_above_threshold +10155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil segments,False,no_term_above_threshold +10156,87489,17.09562,0.80859375,GPI-anchor,keyword,87522,Glycoprotein,0.6923828,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9067619047619049,0.05687860927729265,0.0031014621178555605,,18.339288734121357,2.0,18.0,16.35692729766804,0.011242642248779309,Extracellular juxtamembrane stalk,True,assigned_and_evaluated +10157,52236,17.574577,0.8354492,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.73828125,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,19.0,164.5365661344372,3.7958279824341706e-29,Alpha-helical PPI scaffolds,True,assigned_too_few_test_positives +10158,82029,32.683475,1.0,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99121094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS TM3/TM9 hydrophobic gate,True,assigned_too_few_test_positives +10159,49116,26.205097,0.9814453,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9814453,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9994671403197157,0.6861904761904762,0.002215330084182543,1.0,309.746380952381,20.0,20.0,87.03795620437957,8.990576307619231e-39,HEAT/ARM alpha-solenoid repeats,True,assigned_and_evaluated +10160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,G-patch acidic low-complexity tails,False,no_term_above_threshold +10161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse intradomain activation,False,no_term_above_threshold +10162,82716,16.733992,0.83251953,Laminin,gene3d,82716,Laminin,0.83251953,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,0.0,11.0,0.0,1.0,Disulfide-stabilized extracellular ectodomains,True,assigned_too_few_test_positives +10163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical domain–IDR junctions,False,no_term_above_threshold +10164,87326,25.729471,0.64160156,Coiled coil,keyword,87326,Coiled coil,0.64160156,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6469640117749492,0.22867853048445969,0.03943287549844927,0.1797752808988764,5.799184756218264,9.0,19.0,5.971986956183014,1.026054543559621e-05,Amphipathic N-terminal assembly helix,True,assigned_and_evaluated +10165,64148,27.783806,0.8051758,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7861328,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9640891773670099,0.44621738216182816,0.008418254319893664,0.21052631578947367,53.0059279757498,2.0,17.0,10.46900790166813,0.025941455582506812,Macromolecular assembly interaction regions,True,assigned_and_evaluated +10166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic sugar-binding catalytic cores,False,no_term_above_threshold +10167,64026,18.18678,0.8598633,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.7084961,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.8632459647564047,0.019877147601967078,0.002658396101019052,,7.477120356273282,0.0,19.0,0.0,1.0,Hydrophobic transmembrane helix cores,True,assigned_and_evaluated +10168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic helical rod scaffolds,False,no_term_above_threshold +10169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PurL synthetase ATP/Mg region,False,no_term_above_threshold +10170,37341,24.050907,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9941406,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,19.0,19.0,145.4170731707317,5.254240088122417e-41,WD beta-propeller strand hotspots,True,assigned_and_evaluated +10171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+-linked C-terminal HTH DNA-binding domains,False,no_term_above_threshold +10172,58239,29.119307,0.86035156,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.86035156,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8412832656743348,0.10595220202934394,0.017722640673460344,,5.9783529995057325,10.0,11.0,32.59224840102771,6.941692638995478e-15,Conserved NTPase cores and scaffolds,True,assigned_and_evaluated +10173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic β-sandwich after TM,False,no_term_above_threshold +10174,64058,23.347216,0.65966797,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.64941406,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6389083497866377,0.1716075309166644,0.006202924235711121,0.14285714285714285,27.665585519922253,14.0,14.0,113.99808795411089,4.8145062114693447e-29,C-terminal SDR substrate pocket,True,assigned_and_evaluated +10175,46932,16.577887,0.87939453,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.87939453,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.8840231419670672,0.11025624968649708,0.004430660168365086,0.1,24.884835554242393,0.0,12.0,0.0,1.0,Conserved acidic domain core residues,True,assigned_and_evaluated +10176,47128,15.948077,0.9560547,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9560547,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,10.0,12.0,214.1558908045977,1.1945958781431035e-22,Aromatic-acidic edge loops,True,assigned_too_few_test_positives +10177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P/S/T-rich mucin-like linkers,False,no_term_above_threshold +10178,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SM fold C-terminal hotspot,False,no_term_above_threshold +10179,87697,16.982122,0.7734375,Knottin,keyword,87697,Knottin,0.7734375,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8340269589142447,0.04925371595724366,0.017279574656623838,,2.8504009465512548,0.0,17.0,0.0,1.0,Histidine-centered catalytic motifs,True,assigned_and_evaluated +10180,64596,26.289118,0.9863281,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9863281,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,16.0,16.0,614.6494845360825,1.2591841130090904e-44,MBL-fold binuclear metallophosphoesterases,True,assigned_too_few_test_positives +10181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic leader helix,False,no_term_above_threshold +10182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal charged SLiMs,False,no_term_above_threshold +10183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SP/TP-rich cell-cycle IDRs,False,no_term_above_threshold +10184,38317,16.822136,0.67041016,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.67041016,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.49755555555555553,0.0031014621178555605,0.0031014621178555605,,1.0,0.0,16.0,0.0,1.0,Pore-lining lateral-gate TM helices,True,assigned_and_evaluated +10185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble-domain block detector,False,no_term_above_threshold +10186,86130,25.152998,0.9477539,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,64146,Winged helix-like DNA-binding domain superfamily,0.9116211,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.8984126984126984,0.03862614949638901,0.0031014621178555605,,12.454174201907142,0.0,18.0,0.0,1.0,wHTH beta-hairpin wing,True,assigned_and_evaluated +10187,58239,16.121521,0.7216797,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7216797,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8412719891745601,0.08494204584358414,0.017722640673460344,,4.792854936724235,1.0,12.0,2.987622770094207,0.45155246811732924,Solvent-exposed amphipathic interface helices,True,assigned_and_evaluated +10188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic low-complexity tracts,False,no_term_above_threshold +10189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich beta-to-alpha phosphate-gripper loops,False,no_term_above_threshold +10190,87390,15.660506,0.7578125,Defensin,keyword,87390,Defensin,0.7578125,37,keywords,Defensin,keyword:keywords:Defensin,,,,,,,,0.0,19.0,0.0,1.0,Conserved noncatalytic subdomain motifs,True,assigned_too_few_test_positives +10191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-helical N-terminal thiol/docking loop,False,no_term_above_threshold +10192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-bundle channels,False,no_term_above_threshold +10193,59229,35.956463,0.9819336,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9819336,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8629675761939978,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,14.0,14.0,106.27629233511585,1.2612068461381496e-28,Motif I SAM-binding beta-strand,True,assigned_and_evaluated +10194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic beta-strand residues,False,no_term_above_threshold +10195,63774,24.85735,0.99121094,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9848633,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,13.0,13.0,182.88650306748465,1.1408790049918726e-29,Nuclear N-terminal disordered scaffolds,True,assigned_too_few_test_positives +10196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear interdomain hydrophobic stretches,False,no_term_above_threshold +10197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged catalytic channel segments,False,no_term_above_threshold +10198,82029,18.26082,0.86035156,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6772461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane helix–loop junctions,True,assigned_too_few_test_positives +10199,52236,17.612038,0.9921875,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9873047,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,18.0,173.67748647523928,1.0369554419320324e-29,TPR/alpha-solenoid caps and linkers,True,assigned_too_few_test_positives +10200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix and tail,False,no_term_above_threshold +10201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic phosphate binding hotspots,False,no_term_above_threshold +10202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical regions,False,no_term_above_threshold +10203,85672,22.92498,0.64208984,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.64208984,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5935952273750562,0.15122691076099187,0.01595037660611431,0.1111111111111111,9.481087155209963,13.0,13.0,40.01409395973155,3.774017721320684e-21,ASCE P-loop helicase motor core,True,assigned_and_evaluated +10204,4066,19.533834,0.8979492,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.8979492,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.8934280639431618,0.43746434261258116,0.002215330084182543,0.6,197.47140425531916,12.0,20.0,430.9951807228916,1.0701690889352076e-29,Nucleotide-processing catalytic cores,True,assigned_and_evaluated +10205,37894,25.946156,0.9550781,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9550781,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,8.0,0.0,1.0,ABC NBD helix N-cap,True,assigned_too_few_test_positives +10206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chorismate-utilizing enzyme fold signature,False,no_term_above_threshold +10207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1 and Moco-binding motif,False,no_term_above_threshold +10208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage N-terminal assembly β-strand motif,False,no_term_above_threshold +10209,46079,17.449732,0.734375,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.734375,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.7246332099273276,0.020078865355247888,0.0057598582188746125,,3.4859999312918832,0.0,18.0,0.0,1.0,Amphipathic helical docking modules,True,assigned_and_evaluated +10210,82107,28.917938,0.8901367,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.87939453,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,15.0,0.0,1.0,Noncatalytic helix-coil boundary segments,True,assigned_too_few_test_positives +10211,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site lid/hinge loops,False,no_term_above_threshold +10212,45324,20.541422,0.91796875,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.91796875,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.49489342806394315,0.002215330084182543,0.002215330084182543,,1.0,16.0,16.0,546.9816513761467,8.086221761424609e-44,PbH1 glycine loop motif,True,assigned_and_evaluated +10213,45324,20.751072,0.96240234,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.96240234,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.999822380106572,0.9266666666666665,0.002215330084182543,1.0,418.2973333333333,11.0,18.0,334.26656472986747,4.493775647701214e-26,Surface passenger beta-strand activation,True,assigned_and_evaluated +10214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gag-like basic helical patch,False,no_term_above_threshold +10215,39958,17.729969,0.99902344,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.99902344,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.998037909077447,0.4103174603174603,0.002658396101019052,1.0,154.34775132275132,1.0,19.0,24.904344193817874,0.0652305142409498,Arg/Lys-rich disordered repeats,True,assigned_and_evaluated +10216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic targeting segments,False,no_term_above_threshold +10217,64594,19.37081,0.7939453,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,64594,Zn(2)-C6 fungal-type DNA-binding domain superfamily,0.7939453,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.7374388617163183,0.03697738778349916,0.003544528134692069,,10.4322455284197,0.0,19.0,0.0,1.0,Low-complexity coiled-coil interaction regions,True,assigned_and_evaluated +10218,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity assembly interfaces,False,no_term_above_threshold +10219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Residue-level functional hotspots,False,no_term_above_threshold +10220,64026,19.918694,0.94384766,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.80078125,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9466533392566266,0.027830271746805066,0.002658396101019052,,10.468820555423171,0.0,16.0,0.0,1.0,Multipass membrane alpha-helices,True,assigned_and_evaluated +10221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ER lumenal acceptor-recognition domains,False,no_term_above_threshold +10222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic membrane and interface segments,False,no_term_above_threshold +10223,87697,23.836397,0.8676758,Knottin,keyword,87697,Knottin,0.8676758,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9782779588911239,0.31148232813769167,0.017279574656623838,,18.026041400173593,0.0,18.0,0.0,1.0,Structured interface scaffold signal,True,assigned_and_evaluated +10224,87882,37.019936,0.9140625,Palmitate,keyword,88058,Signal,0.6738281,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9988153413297793,0.5382936507936509,0.002658396101019052,1.0,202.48812830687834,15.0,17.0,58.7785080512652,1.6101838264944757e-25,Sec signal peptide cleavage site,True,assigned_and_evaluated +10225,37020,20.341333,0.9970703,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9711914,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,18.0,725.9786910197869,1.266441663928211e-44,GT acidic donor-binding motif,True,assigned_too_few_test_positives +10226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic catalytic scaffold helices,False,no_term_above_threshold +10227,84879,15.727051,0.8095703,"Histidine kinase-like ATPase, C-terminal domain",gene3d,88152,Transducer,0.6748047,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,19.0,19.0,327.5879120879121,2.280800775428487e-47,Histidine kinase DHp helix,True,assigned_too_few_test_positives +10228,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cas10 and FBP catalytic hotspots,False,no_term_above_threshold +10229,30856,18.855387,0.80126953,transmembrane transporter activity,go_mf,87276,Cell membrane,0.6303711,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7448490230905861,0.008609409913569649,0.002215330084182543,,3.8862876349853397,4.0,19.0,28.206268480189234,2.0255407829647747e-05,TM helix starts and kinks,True,assigned_and_evaluated +10230,55054,23.978088,1.0,HAD superfamily,interpro,55054,HAD superfamily,1.0,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8966696269982238,0.7147287803025508,0.002215330084182543,0.8,322.6285714285715,17.0,17.0,334.9494382022472,7.26757959387553e-43,Substrate-positioning cap helix-loop,True,assigned_and_evaluated +10231,87970,19.549828,0.7739258,Protein phosphatase,keyword,87970,Protein phosphatase,0.7739258,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,0.0,15.0,0.0,1.0,FabD-like acyltransferase domain,True,assigned_too_few_test_positives +10232,38873,22.142685,0.98535156,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.89746094,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9990230905861457,0.7388888888888889,0.002215330084182543,1.0,333.5344444444445,13.0,13.0,171.32471264367817,2.6588953672088044e-29,ABC P-loop H1 helix,True,assigned_and_evaluated +10233,38654,26.229616,0.99902344,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99853516,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,Serine protease specificity loops,True,assigned_too_few_test_positives +10234,37430,19.02379,1.0,"Signal transduction response regulator, receiver domain",interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9350586,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,Conserved active-site carboxylate,True,assigned_too_few_test_positives +10235,87326,18.014294,0.61865234,Coiled coil,keyword,87326,Coiled coil,0.61865234,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6296306853517974,0.08677320131683808,0.03943287549844927,0.011235955056179775,2.2005293862034105,8.0,17.0,5.932954361698158,3.653268771697357e-05,Coiled-coil oligomerization helices,True,assigned_and_evaluated +10236,87317,17.03606,0.71875,Cleavage on pair of basic residues,keyword,88058,Signal,0.6176758,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.6860218652387327,0.028453694726951664,0.007089056269384138,,4.013749312420619,0.0,17.0,0.0,1.0,Mature secreted/periplasmic catalytic cores,True,assigned_and_evaluated +10237,87413,57.913383,0.89697266,Disulfide bond,keyword,87413,Disulfide bond,0.89697266,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9379386546450985,0.5946106817089545,0.0717766947275144,0.8888888888888888,8.284174744550064,19.0,20.0,11.23585598095616,1.882914874701622e-19,Cysteine-rich ectodomains and propeptides,True,assigned_and_evaluated +10238,63960,17.605698,0.7504883,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.7504883,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,12.0,0.0,1.0,Walker A-alpha1 module,True,assigned_too_few_test_positives +10239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain boundary linker,False,no_term_above_threshold +10240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar loop hotspots; S/T-rich disorder,False,no_term_above_threshold +10241,87873,17.465008,0.6274414,Oxidoreductase,keyword,87873,Oxidoreductase,0.6274414,537,keywords,Oxidoreductase,keyword:keywords:Oxidoreductase,48.0,2257.0,0.6762769729892862,0.10753219171820975,0.021267168808152416,,5.056253264749987,0.0,15.0,0.0,1.0,Catalytic pocket rim loops,True,assigned_and_evaluated +10242,87276,28.421358,0.61865234,Cell membrane,keyword,87276,Cell membrane,0.61865234,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6970075828292016,0.2748002341204282,0.11120957022596367,0.43824701195219123,2.4710124637840893,7.0,15.0,3.8292228644829804,0.0018398556591574554,Glycosylation machinery transmembrane helices,True,assigned_and_evaluated +10243,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic core packing helix,False,no_term_above_threshold +10244,82029,17.448322,0.9160156,MFS general substrate transporter like domains,gene3d,88162,Transport,0.60498047,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,20.0,0.0,1.0,Outer-membrane β-barrel domain,True,assigned_too_few_test_positives +10245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal histidine phosphatase elements,False,no_term_above_threshold +10246,37894,21.900433,0.8959961,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8959961,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,C-terminal RNA-kinase/IDR activation,True,assigned_too_few_test_positives +10247,36914,25.136633,0.97998047,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.97998047,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,17.0,692.7639796659404,9.231629051889402e-45,Glycosyltransferase DXD catalytic core,True,assigned_too_few_test_positives +10248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic multi-pass transmembrane helices,False,no_term_above_threshold +10249,38878,16.499027,0.9819336,Immunoglobulin subtype,interpro,87413,Disulfide bond,0.61572266,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,16.0,19.0,188.04178986792823,8.014915469768169e-35,Single-pass or GPI-anchored IgSF,True,assigned_too_few_test_positives +10250,36535,22.467445,0.8046875,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.7993164,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.7484423676012462,0.397669875538728,0.004430660168365086,0.4,89.75409090909092,0.0,10.0,0.0,1.0,Amphipathic coiled-coil oligomerization,True,assigned_and_evaluated +10251,36535,18.09951,0.96191406,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.95410156,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9474632843791722,0.8904430660168365,0.004430660168365086,0.9,200.973,17.0,17.0,89.79066265060241,2.357720211227094e-33,APE motif activation hotspot,True,assigned_and_evaluated +10252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPT16 SGGxYDL motif,False,no_term_above_threshold +10253,85364,20.572418,0.99316406,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.99316406,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,Helix-to-beta junction loops,True,assigned_too_few_test_positives +10254,64146,23.425718,0.6713867,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6713867,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.6465932211800903,0.08736939569690942,0.007975188303057155,0.05555555555555555,10.955151449329144,1.0,14.0,4.77426329276105,0.30087148670307323,N-terminal partner-binding modules,True,assigned_and_evaluated +10255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-interface aromatic-Gly segments,False,no_term_above_threshold +10256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha helix capping,False,no_term_above_threshold +10257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pilin D-region amphipathic linker,False,no_term_above_threshold +10258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal nucleotide-catalytic motifs,False,no_term_above_threshold +10259,36104,19.919088,0.99853516,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99853516,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic alpha-helical packing segments,True,assigned_too_few_test_positives +10260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal secretory leader/propeptide,False,no_term_above_threshold +10261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-ATP-binding flexible tails,False,no_term_above_threshold +10262,50338,17.518759,0.8066406,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8066406,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,7.0,0.0,1.0,LspA TM1 periplasmic loop,True,assigned_too_few_test_positives +10263,64058,16.185776,0.7006836,NAD(P)-binding domain superfamily,interpro,87873,Oxidoreductase,0.6328125,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8394688236418063,0.11900585096596547,0.006202924235711121,,19.18544325929886,4.0,14.0,32.57088227260311,1.0272716541580718e-05,Fungal enzyme and transporter cores,True,assigned_and_evaluated +10264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible linker/hinge loops,False,no_term_above_threshold +10265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal effector modules,False,no_term_above_threshold +10266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic Cache/dCache sensor domains,False,no_term_above_threshold +10267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered tails/linkers,False,no_term_above_threshold +10268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase/tRNase domain-wide activation,False,no_term_above_threshold +10269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C1 cofactor-binding catalytic subdomain,False,no_term_above_threshold +10270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site adjacent beta-alpha module,False,no_term_above_threshold +10271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface helix-coil interaction modules,False,no_term_above_threshold +10272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure capping motifs,False,no_term_above_threshold +10273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop junctions,False,no_term_above_threshold +10274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal IDR activation signature,False,no_term_above_threshold +10275,30398,17.27503,0.68066406,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6640625,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.663725410831377,0.0178952121751557,0.004873726185201595,,3.671772170847856,5.0,8.0,45.00377415458937,5.492924269893663e-08,P-loop NTPase nucleotide-binding module,True,assigned_and_evaluated +10276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal β-rich nucleic-acid lobe,False,no_term_above_threshold +10277,45290,16.88316,0.6816406,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.6816406,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.5347593582887701,0.08223986912511504,0.0057598582188746125,0.07692307692307693,14.27810650887574,14.0,17.0,60.46754563894523,1.282211861994168e-23,Mid-domain non-catalytic patches,True,assigned_and_evaluated +10278,87277,16.27692,0.74658203,Cell outer membrane,keyword,88058,Signal,0.60058594,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.9197777777777778,0.1633261208353752,0.0031014621178555605,,52.661007817920265,4.0,20.0,29.2977886977887,1.77668342032528e-05,N-terminal Sec lipoprotein signal peptides,True,assigned_and_evaluated +10279,37020,18.518969,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.97998047,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,18.0,19.0,773.7404470079307,1.0307916309183318e-50,Glycosyltransferase NDP-sugar binding motif,True,assigned_too_few_test_positives +10280,64154,19.574783,0.96972656,Cytochrome P450 superfamily,interpro,64154,Cytochrome P450 superfamily,0.96972656,36,ip,IPR036396,interpro:ip:IPR036396,9.0,2257.0,0.9997528667457493,0.9361111111111111,0.003987594151528578,1.0,234.75586419753088,11.0,11.0,379.75159235668787,1.036047218458191e-28,P450 SRS-1 lid loop,True,assigned_and_evaluated +10281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic accessory modules,False,no_term_above_threshold +10282,36010,19.435797,0.99609375,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9091797,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,12.0,12.0,509.58119658119665,8.111562053042622e-33,ABH cap/lid subdomain,True,assigned_too_few_test_positives +10283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PDZ/PDZ-like groove recognition,False,no_term_above_threshold +10284,45714,18.722754,0.84277344,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.84277344,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase phosphotransfer helix,True,assigned_too_few_test_positives +10285,45324,15.990412,0.97558594,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.97558594,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9944937833037301,0.1836930226636109,0.002215330084182543,,82.91903043035397,16.0,16.0,546.9816513761467,8.086221761424609e-44,beta-helix/beta-solenoid repeat detector,True,assigned_and_evaluated +10286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA Pol III LYTPK/MPKF motif,False,no_term_above_threshold +10287,36668,20.926027,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.98583984,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,11.0,11.0,532.3303571428571,2.3868640396304885e-30,Adenylation domain internal loop,True,assigned_too_few_test_positives +10288,36499,16.35923,0.9604492,"Zinc finger, GATA-type",interpro,82608,Ankyrin repeat-containing domain,0.8925781,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,14.0,0.0,1.0,Coil-to-beta glycine N-caps,True,assigned_too_few_test_positives +10289,58239,21.25748,0.7421875,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7421875,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7493290482634191,0.058227361930744764,0.017722640673460344,,3.2854788969422737,0.0,16.0,0.0,1.0,Ser/Thr phosphate-binding loops,True,assigned_and_evaluated +10290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered phospho-rich regulatory tails,False,no_term_above_threshold +10291,28622,18.36756,0.7397461,transposase activity,go_mf,88164,Transposition,0.71435547,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.8980461811722913,0.64377639935017,0.002215330084182543,0.8,290.6006666666667,1.0,14.0,81.89697802197801,0.020654056711970042,KDEFY motif upstream DDE Tnp4,True,assigned_and_evaluated +10292,72011,16.63929,0.96972656,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.96972656,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,12.0,0.0,1.0,Two-metal acidic palm motif,True,assigned_too_few_test_positives +10293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular cupredoxin-like copper domains,False,no_term_above_threshold +10294,87852,19.953306,0.9892578,Nucleosome core,keyword,24789,nucleosome,0.98046875,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,12.0,19.0,396.3722991689751,2.3756088095863463e-29,Polybasic nucleic acid condensers,True,assigned_too_few_test_positives +10295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane aromatic anchors,False,no_term_above_threshold +10296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transit peptides,False,no_term_above_threshold +10297,64058,17.79166,0.83740234,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.83251953,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9511018406470926,0.07613889556079746,0.006202924235711121,,12.274677662908562,1.0,15.0,7.599872530274059,0.1987215180798853,Surface cationic amphipathic helices,True,assigned_and_evaluated +10298,46284,22.359446,0.93408203,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.93408203,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,18.0,0.0,1.0,PAS-family sensory domains,True,assigned_too_few_test_positives +10299,85649,42.190956,0.9765625,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9707031,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8886866996224358,0.708225123785792,0.0101905183872397,0.782608695652174,69.49843932106663,17.0,17.0,110.61410018552876,7.110790058883305e-35,SAM MTase active-site lid,True,assigned_and_evaluated +10300,87525,16.109251,0.86083984,Glycosyltransferase,keyword,87525,Glycosyltransferase,0.86083984,112,keywords,Glycosyltransferase,keyword:keywords:Glycosyltransferase,7.0,2257.0,0.8302857142857143,0.34272286672755053,0.0031014621178555605,0.5714285714285714,110.5036443148688,17.0,18.0,89.2372776897341,1.6463844284682493e-32,EG[FL]P phosphate-binding N-cap,True,assigned_and_evaluated +10301,50869,19.354061,0.87597656,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.87597656,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,12.0,0.0,1.0,Tryptophan-centered motifs in alpha/beta domains,True,assigned_too_few_test_positives +10302,87857,19.667475,0.6538086,Nucleus,keyword,24917,nucleus,0.64941406,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6769094638619635,0.13482839198856758,0.06247230837394772,0.0070921985815602835,2.158210501547497,11.0,16.0,4.165593241869918,8.954506678607137e-06,Amphipathic dimerization interface helix,True,assigned_and_evaluated +10303,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet lipid-transfer domains,False,no_term_above_threshold +10304,59224,16.811092,0.9111328,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8017578,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.949968253968254,0.04521426561307443,0.0031014621178555605,,14.578371069815569,0.0,19.0,0.0,1.0,Post-beta-strand catalytic rim residues,True,assigned_and_evaluated +10305,87276,30.461031,0.6044922,Cell membrane,keyword,87276,Cell membrane,0.6044922,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6723246594876725,0.34334048448599247,0.11120957022596367,0.3705179282868526,3.087328579621056,14.0,19.0,6.046141364973126,2.0637448112889375e-09,Catalytic extracellular loop motifs,True,assigned_and_evaluated +10306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic N-terminal leader,False,no_term_above_threshold +10307,88263,20.123716,0.7651367,Zinc-finger,keyword,88263,Zinc-finger,0.7651367,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8741620340091563,0.09448948150710675,0.014621178555604785,,6.462507871561816,4.0,17.0,6.131324557795145,0.005951082834709425,Amphipathic interaction helices and caps,True,assigned_and_evaluated +10308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic TM–loop caps,False,no_term_above_threshold +10309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended non-propeller core regions,False,no_term_above_threshold +10310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Pro-rich C-terminal IDRs,False,no_term_above_threshold +10311,64016,17.74984,0.68408203,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.6801758,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8480000000000001,0.3816433529548283,0.0031014621178555605,0.2857142857142857,123.05272108843536,12.0,16.0,166.2295539033457,3.032460172604699e-25,GST C-terminal helical module,True,assigned_and_evaluated +10312,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HAMP–DHp signaling linker,False,no_term_above_threshold +10313,36914,24.267246,0.9785156,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8857422,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,1.0,16.0,46.00385802469136,0.036199068281376375,Glycosyltransferase catalytic core motif,True,assigned_too_few_test_positives +10314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered propeptides and linkers,False,no_term_above_threshold +10315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ala/Ser/Thr-rich Secretin domain,False,no_term_above_threshold +10316,37468,20.270332,0.97753906,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.92041016,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,18.0,0.0,1.0,Cys/His knuckle loops,True,assigned_too_few_test_positives +10317,85649,48.165806,0.9633789,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9580078,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8904966719862987,0.7579209212504683,0.0101905183872397,0.782608695652174,74.37510953314377,17.0,17.0,110.61410018552876,7.110790058883305e-35,Rossmann-like MTase catalytic helix,True,assigned_and_evaluated +10318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic/disulfide structural stabilizers,False,no_term_above_threshold +10319,36535,28.19066,0.96484375,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.95166016,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9493769470404984,0.852546240620011,0.004430660168365086,0.9,192.41968650793652,0.0,14.0,0.0,1.0,Conserved alpha-glycosidase C-terminal subdomain,True,assigned_and_evaluated +10320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Focal mid/C-terminal non-DBD hotspots,False,no_term_above_threshold +10321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic aromatic binding loops,False,no_term_above_threshold +10322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered terminal/linker regions,False,no_term_above_threshold +10323,25169,22.573572,0.8955078,pilus,go_cc,25169,pilus,0.8955078,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8980017761989343,0.5171097326835031,0.002215330084182543,0.8,233.42333333333332,10.0,17.0,324.7331154684096,1.375076471504845e-23,Small polar beta-loop interfaces,True,assigned_and_evaluated +10324,50779,17.781668,0.91015625,Myb domain,interpro,43624,Homedomain-like superfamily,0.73095703,33,ip,IPR017930,interpro:ip:IPR017930,5.0,2257.0,0.9952486678507992,0.510846394984326,0.002215330084182543,0.4,230.5960626959248,0.0,19.0,0.0,1.0,Major-groove DNA recognition helices,True,assigned_and_evaluated +10325,38654,21.072193,0.9536133,B3 DNA binding domain,interpro,46277,"Nucleic acid-binding, OB-fold",0.93115234,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,ssDNA-binding OB-fold domain,True,assigned_too_few_test_positives +10326,50869,18.645935,0.98876953,"DNA binding HTH domain, AraC-type",interpro,80926,Homeodomain-like,0.8334961,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,19.0,0.0,1.0,Polar N-caps preceding nucleic-acid helices,True,assigned_too_few_test_positives +10327,38317,18.823246,0.87402344,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8666992,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6730158730158731,0.0092561694621992,0.0031014621178555605,,2.9844534965976566,0.0,18.0,0.0,1.0,Alpha-helical PPI scaffolds,True,assigned_and_evaluated +10328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic surface β-strand/loop motifs,False,no_term_above_threshold +10329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metzincin metalloprotease catalytic domain,False,no_term_above_threshold +10330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein soluble domains,False,no_term_above_threshold +10331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic beta-sheet ligand scaffolds,False,no_term_above_threshold +10332,49061,23.842041,0.97802734,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97802734,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9942158559251426,0.47911674822518846,0.012405848471422242,1.0,38.620232169437514,6.0,20.0,29.662189054726365,7.119845702315219e-08,Beta-propeller blade hydrophobes,True,assigned_and_evaluated +10333,46079,36.711273,0.9682617,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9682617,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9560880296174414,0.4384542558674913,0.0057598582188746125,0.38461538461538464,76.12240426868676,13.0,20.0,60.552578125000004,4.307798636346686e-21,Long amphipathic helical bundles,True,assigned_and_evaluated +10334,8305,15.882077,0.7636719,fatty acid biosynthetic process,go_bp,8305,fatty acid biosynthetic process,0.7636719,31,go,GO:0006633,go_bp:go:GO:0006633,9.0,2257.0,0.9955516014234874,0.31012718218600577,0.003987594151528578,,77.77300557709056,0.0,14.0,0.0,1.0,GHMP kinase catalytic core,True,assigned_and_evaluated +10335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical domain cores,False,no_term_above_threshold +10336,63831,15.764856,0.8730469,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8730469,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7755812231600772,0.006493205318293187,0.002658396101019052,,2.4425274005646203,0.0,14.0,0.0,1.0,Exposed non-membrane helical faces,True,assigned_and_evaluated +10337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand N-cap triads,False,no_term_above_threshold +10338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic coiled-coil stalks,False,no_term_above_threshold +10339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-alpha loops,False,no_term_above_threshold +10340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic substrate-gating loops,False,no_term_above_threshold +10341,46932,16.213146,0.8989258,Zinc finger C2H2-type,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.79052734,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9530485091232754,0.07430048135423528,0.004430660168365086,,16.769618641650904,0.0,15.0,0.0,1.0,Boundary and processing residues,True,assigned_and_evaluated +10342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,T9SS CTD cleavage motif,False,no_term_above_threshold +10343,87149,19.75069,0.7602539,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.7602539,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.5890133307697237,0.014624366477023403,0.012405848471422242,,1.1788283978086365,0.0,13.0,0.0,1.0,C-terminal alpha-helix motif,True,assigned_and_evaluated +10344,64594,16.768208,0.9604492,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,29166,zinc ion binding,0.8515625,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9911349488661627,0.169983752015002,0.003544528134692069,,47.95666603723244,0.0,18.0,0.0,1.0,Short Cys/His zinc-binding motifs,True,assigned_and_evaluated +10345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory engagement/coupling regions,False,no_term_above_threshold +10346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic beta-sandwich adaptors,False,no_term_above_threshold +10347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel strands,False,no_term_above_threshold +10348,38317,18.437153,0.93603516,Pentatricopeptide repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.83984375,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.901904761904762,0.017316710575563124,0.0031014621178555605,,5.583402252720853,0.0,14.0,0.0,1.0,Hydrophobic alpha-helix packing signal,True,assigned_and_evaluated +10349,87586,17.439917,0.6850586,Host membrane,keyword,88161,Transmembrane helix,0.62597656,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.8027087898709521,0.16160716982939088,0.01639344262295082,,9.858037359592844,0.0,20.0,0.0,1.0,Type I cytosolic tails,True,assigned_and_evaluated +10350,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible boundary hotspot residues,False,no_term_above_threshold +10351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved WEWT beta-loop motif,False,no_term_above_threshold +10352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cupin/VOC metallo-beta-barrel core,False,no_term_above_threshold +10353,50338,17.769453,0.99902344,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.96972656,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,15.0,17.0,346.0971362229102,5.10145670369755e-37,GPCR TM2–ICL1 helical signature,True,assigned_too_few_test_positives +10354,46082,16.49736,0.86621094,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.86621094,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.7055873015873015,0.11752317981826178,0.0031014621178555605,,37.89283097854526,18.0,18.0,150.93924050632913,3.153793419099765e-39,FERM/PTB/PH beta-sandwich and acidic LC,True,assigned_and_evaluated +10355,84152,19.50677,0.9667969,Metal-dependent hydrolases,gene3d,47531,Aldolase-type TIM barrel,0.95751953,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,12.0,0.0,1.0,alpha/beta helix-loop-beta scaffolds,True,assigned_too_few_test_positives +10356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-residue motif anchors,False,no_term_above_threshold +10357,42974,15.808301,0.90283203,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8076172,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.8560634920634921,0.6627908939384348,0.0031014621178555605,0.7142857142857143,213.70272108843534,3.0,9.0,44.360863095238095,6.310438029607536e-05,C-terminal mixed-charge disordered tails,True,assigned_and_evaluated +10358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic stalk/linker regions,False,no_term_above_threshold +10359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PNPLA catalytic cleft region,False,no_term_above_threshold +10360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,L7Ae-like RNA-binding patch,False,no_term_above_threshold +10361,49116,21.988276,0.89501953,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.89501953,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9984014209591474,0.6264425770308124,0.002215330084182543,0.8,282.7761792717087,17.0,20.0,73.98226277372262,3.6634970709041876e-30,HEAT/ARM alpha-solenoid scaffolds,True,assigned_and_evaluated +10362,36535,20.18757,0.95703125,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.94970703,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9481308411214953,0.8904430660168365,0.004430660168365086,0.9,200.973,19.0,19.0,89.79066265060241,3.7420828801112705e-37,Kinase activation-segment N-cap junction,True,assigned_and_evaluated +10363,87276,28.035173,0.6098633,Cell membrane,keyword,25079,plasma membrane,0.60839844,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.5997853054382669,0.24117627264870123,0.11120957022596367,0.199203187250996,2.1686647305502733,7.0,15.0,3.8292228644829804,0.0018398556591574554,Transmembrane helix interfaces,True,assigned_and_evaluated +10364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted glycoprotein loop motifs,False,no_term_above_threshold +10365,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-rich regulatory IDRs,False,no_term_above_threshold +10366,63831,26.652178,0.9980469,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9980469,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9997038353324449,0.9333333333333333,0.002658396101019052,1.0,351.08888888888885,19.0,19.0,245.3539094650206,4.042342321216249e-45,CRL scaffold-recruiting helix,True,assigned_and_evaluated +10367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical scaffold cores,False,no_term_above_threshold +10368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad low-complexity disordered regions,False,no_term_above_threshold +10369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix–coil boundary and capping,False,no_term_above_threshold +10370,85664,23.395027,0.96972656,Glycogen Phosphorylase B;,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.7216797,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,C-terminal glycosyltransferase active-site helix,True,assigned_too_few_test_positives +10371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA/RNA-binding regulatory domains,False,no_term_above_threshold +10372,37894,15.86478,0.8041992,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8041992,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,HATPase_c F-box/ATP-lid helix,True,assigned_too_few_test_positives +10373,47717,16.766653,0.95751953,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.80029297,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,14.0,0.0,1.0,ABC NBD Walker B activation,True,assigned_too_few_test_positives +10374,37282,18.48953,0.99902344,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.9975586,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,LRR C-terminal cap,True,assigned_too_few_test_positives +10375,48255,16.807076,0.74902344,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.74902344,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,18.0,18.0,340.69142857142856,2.558082930606347e-45,Adenylate/phosphate-handling active-site loop,True,assigned_too_few_test_positives +10376,64026,16.993196,0.90527344,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.86621094,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.928883459203317,0.020140443355993794,0.002658396101019052,,7.576163442412999,0.0,13.0,0.0,1.0,Transmembrane helix N-cap detector,True,assigned_and_evaluated +10377,82029,15.720895,0.70214844,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.69628906,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,18.0,10.448825797406238,0.1483822125694642,Multi-pass transmembrane helices,True,assigned_too_few_test_positives +10378,36914,22.19249,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Glycosyltransferase pyrophosphate-binding helix,True,assigned_too_few_test_positives +10379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter pore-lining helices,False,no_term_above_threshold +10380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed acidic low-complexity segments,False,no_term_above_threshold +10381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active-site rim,False,no_term_above_threshold +10382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Subtilase C-terminal catalytic lobe,False,no_term_above_threshold +10383,27735,17.603676,0.82177734,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,88150,Transcription regulation,0.6591797,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.9235337723683757,0.15719697346635797,0.011519716437749225,,13.645906504368075,12.0,16.0,33.92697268588771,5.296630287563682e-17,C-terminal activation tail,True,assigned_and_evaluated +10384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered kinase C-terminal tails,False,no_term_above_threshold +10385,87601,16.074377,0.60058594,Hydrolase,keyword,87601,Hydrolase,0.60058594,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.5921521603493994,0.11085863600399301,0.05316792202038104,0.025,2.0850661788417684,14.0,15.0,10.438241730757206,6.454384133786855e-14,Catalytic short-loop motifs,True,assigned_and_evaluated +10386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid core flanks,False,no_term_above_threshold +10387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-dependent intramembrane metalloprotease loop motif,False,no_term_above_threshold +10388,52941,18.580114,0.9980469,Major facilitator superfamily domain,interpro,37446,F-box domain,0.92626953,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,18.0,19.0,246.65088485405653,3.6509504432924326e-42,Transporter TM boundary/kink motif,True,assigned_too_few_test_positives +10389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transducing transmembrane helices,False,no_term_above_threshold +10390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor TM1/ECL1,False,no_term_above_threshold +10391,87276,30.938244,0.61279297,Cell membrane,keyword,88161,Transmembrane helix,0.609375,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6904287138584247,0.36146290326018915,0.11120957022596367,0.4262948207171315,3.2502859468456053,6.0,19.0,2.5912034421313397,0.03644461949851102,TM1 N-cap signal-anchor,True,assigned_and_evaluated +10392,64475,15.896469,0.8671875,ACP-like superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7993164,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9148155765802826,0.45274947673360233,0.0057598582188746125,0.5384615384615384,78.60427453751849,0.0,17.0,0.0,1.0,SAM-dependent methyltransferase motif I,True,assigned_and_evaluated +10393,87108,15.558398,0.9145508,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.90771484,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8810300514037168,0.02503280596834217,0.003987594151528578,,6.277671452283142,0.0,15.0,0.0,1.0,Small-residue structural scaffolding,True,assigned_and_evaluated +10394,82029,15.596118,0.93066406,MFS general substrate transporter like domains,gene3d,37446,F-box domain,0.92822266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,19.0,0.0,1.0,Leucine-rich amphipathic interface helices,True,assigned_too_few_test_positives +10395,87601,19.050194,0.6118164,Hydrolase,keyword,87601,Hydrolase,0.6118164,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.645903525191078,0.08831759225985823,0.05316792202038104,,1.6611067144208336,13.0,16.0,9.086862220971675,2.1423722288530458e-11,Retroviral aspartyl protease β-strand,True,assigned_and_evaluated +10396,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge hydrophilin IDRs,False,no_term_above_threshold +10397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal accessory interaction module,False,no_term_above_threshold +10398,46081,16.730812,0.7348633,EF-hand domain pair,interpro,46081,EF-hand domain pair,0.7348633,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.6058248110271232,0.01419685763948059,0.003544528134692069,,4.005288461538462,0.0,16.0,0.0,1.0,Acidic SP/TP-rich IDR-helix modules,True,assigned_and_evaluated +10399,87413,19.552444,0.6040039,Disulfide bond,keyword,87413,Disulfide bond,0.6040039,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5469769291964995,0.11337034702602306,0.0717766947275144,,1.5794868718378645,9.0,15.0,7.096330093235469,1.3186734634707885e-06,Extracellular adhesion repeat motifs,True,assigned_and_evaluated +10400,49061,28.900059,0.9873047,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9873047,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9992950073703775,0.8777466434305694,0.012405848471422242,1.0,70.75264907938553,11.0,19.0,57.24282098280527,1.7848532300770983e-17,β-strand N-cap motifs,True,assigned_and_evaluated +10401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,5'-nucleotidase C-terminal substrate-binding/dimerization region,False,no_term_above_threshold +10402,52941,24.575037,0.9746094,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.95458984,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,13.0,15.0,225.63988355167396,1.0871819880391026e-29,Transporter cytosolic C-terminal tails,True,assigned_too_few_test_positives +10403,82107,18.602955,0.9399414,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.93603516,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,11.0,0.0,1.0,Charged/polar helix detector,True,assigned_too_few_test_positives +10404,46933,15.62771,0.80566406,"Zinc finger, NHR/GATA-type",interpro,46933,"Zinc finger, NHR/GATA-type",0.80566406,49,ip,IPR013088,interpro:ip:IPR013088,,,,,,,,15.0,16.0,414.0347222222222,1.0846953858115788e-38,LBD-peaked nuclear receptor activation,True,assigned_too_few_test_positives +10405,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Partner docking motifs,False,no_term_above_threshold +10406,83302,16.46091,0.96191406,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9614258,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9852667368250627,0.35626961825143866,0.004873726185201595,0.36363636363636365,73.10004803577246,13.0,15.0,178.17770114942527,2.3366880447792684e-28,β-strand hydrophobic anchor detector,True,assigned_and_evaluated +10407,85672,19.85417,0.76220703,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.75439453,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8672144679573767,0.12493419586130194,0.01595037660611431,,7.832680001637736,3.0,19.0,6.3180148357470856,0.019055663302813962,Acidic S/G/P active-site loops,True,assigned_and_evaluated +10408,55054,20.945518,0.8754883,HAD superfamily,interpro,55054,HAD superfamily,0.8754883,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.7898756660746004,0.22912533469148033,0.002215330084182543,0.2,103.42717607973422,10.0,18.0,186.08302122347067,4.983711401579139e-21,HAD N-terminal cap segment,True,assigned_and_evaluated +10409,83419,15.985585,0.9580078,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.93359375,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,1.0,17.0,21.38486370157819,0.07560237020184968,Capsid jelly-roll beta-strand motif,True,assigned_too_few_test_positives +10410,31094,19.118347,0.97802734,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.7446289,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9461059190031151,0.5643896749634454,0.004430660168365086,0.7,127.38274963924964,0.0,14.0,0.0,1.0,SDR/Rossmann active-site gating loop,True,assigned_and_evaluated +10411,64596,20.875202,0.9277344,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6816406,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,0.0,15.0,0.0,1.0,GTPase Switch II DxxG loop,True,assigned_too_few_test_positives +10412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide sensing tandem CBS domains,False,no_term_above_threshold +10413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting leaders,False,no_term_above_threshold +10414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic metal-binding catalytic motifs,False,no_term_above_threshold +10415,55054,25.008427,0.99658203,HAD superfamily,interpro,55054,HAD superfamily,0.99658203,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.7944049733570161,0.3270399781875192,0.002215330084182543,0.2,147.62584615384617,18.0,18.0,334.9494382022472,3.408992422977286e-45,Metal-dependent acidic phosphatase signature,True,assigned_and_evaluated +10416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich glycan-binding modules,False,no_term_above_threshold +10417,36115,18.73315,0.8564453,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8334961,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,13.0,0.0,1.0,Motif-adjacent hinge residues,True,assigned_too_few_test_positives +10418,85762,24.206888,0.9165039,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9091797,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,17.0,193.49614604462474,6.046250551273022e-36,N-terminal flavin-binding alpha/beta motif,True,assigned_too_few_test_positives +10419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel loops,False,no_term_above_threshold +10420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-rich low complexity IDRs,False,no_term_above_threshold +10421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,YidC core N-tail activation,False,no_term_above_threshold +10422,88161,43.970005,0.6225586,Transmembrane helix,keyword,88159,Transmembrane,0.6201172,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5984145292461683,0.318560194196239,0.1847585290208241,0.23741007194244604,1.7241975019206508,18.0,19.0,5.141834559087751,2.044185969474243e-12,Cytosolic juxtamembrane linker,True,assigned_and_evaluated +10423,50806,25.061308,0.85058594,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.6972656,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,10.0,0.0,1.0,HTH recognition helix,True,assigned_too_few_test_positives +10424,88009,17.649065,0.6425781,Repeat,keyword,88009,Repeat,0.6425781,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7901862188712666,0.202968819346624,0.07266282676118742,0.006097560975609756,2.7932964955203072,9.0,19.0,4.199483467031891,0.00017105467656777505,S/T-rich low-complexity IDRs,True,assigned_and_evaluated +10425,58239,43.896847,0.76660156,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.76660156,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7468538565629228,0.3827058462452293,0.017722640673460344,0.5,21.594177374387066,11.0,11.0,35.851473241130485,1.888900285303928e-17,P-loop NTPase switch module,True,assigned_and_evaluated +10426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-coordinating acidic loops,False,no_term_above_threshold +10427,59224,27.41245,0.9609375,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9609375,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,137.37557603686636,1.6332112516921354e-38,AB-hydrolase β-strand N-cap,True,assigned_and_evaluated +10428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature Sec-exported extracellular regions,False,no_term_above_threshold +10429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core helix-start activations,False,no_term_above_threshold +10430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed noncatalytic peripheral regions,False,no_term_above_threshold +10431,87882,17.916937,0.6777344,Palmitate,keyword,87882,Palmitate,0.6777344,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8138605064415815,0.04166774478711675,0.002658396101019052,,15.674016664087084,6.0,17.0,23.51140322050608,2.3731609505725215e-07,Post-cleavage secreted N-terminus,True,assigned_and_evaluated +10432,39971,20.4236,0.97753906,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9379883,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,8.0,17.0,311.7437908496732,1.1792394411663088e-18,Catalytic metal-binding loops,True,assigned_too_few_test_positives +10433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C/PPM catalytic domain signature,False,no_term_above_threshold +10434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity regulatory IDRs,False,no_term_above_threshold +10435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat boundary capping helices,False,no_term_above_threshold +10436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic disordered N-termini with SLiMs,False,no_term_above_threshold +10437,27013,16.187086,0.7055664,side of membrane,go_cc,87489,GPI-anchor,0.6982422,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.4911150599733452,0.002658396101019052,0.002658396101019052,,1.0,3.0,13.0,37.592055485498115,0.00011485434933217534,Secreted disulfide-core and linker hotspots,True,assigned_and_evaluated +10438,88026,17.073095,0.6855469,S-adenosyl-L-methionine,keyword,88026,S-adenosyl-L-methionine,0.6855469,166,keywords,S-adenosyl-L-methionine,keyword:keywords:S-adenosyl-L-methionine,7.0,2257.0,0.7734920634920636,0.04897032432914632,0.0031014621178555605,,15.789431715840463,14.0,14.0,78.44868421052632,8.581184286113777e-27,Radical SAM core strand-turn,True,assigned_and_evaluated +10439,88161,21.974247,0.61621094,Transmembrane helix,keyword,88161,Transmembrane helix,0.61621094,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6422120998853091,0.2668455584962679,0.1847585290208241,0.002398081534772182,1.4442935863934692,3.0,17.0,0.9577927119869342,0.9751706915332781,Ubiquitous structural anchor signal,True,assigned_and_evaluated +10440,82716,16.453728,0.8857422,Laminin,gene3d,87522,Glycoprotein,0.6035156,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,0.0,11.0,0.0,1.0,Extracellular ectodomain signature,True,assigned_too_few_test_positives +10441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent loops and helices,False,no_term_above_threshold +10442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PPIase foldase core activation,False,no_term_above_threshold +10443,45290,35.99799,0.9760742,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9760742,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9613327848621966,0.9176028293304457,0.0057598582188746125,0.9230769230769231,159.30996813837044,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase N-lobe MEY motif,True,assigned_and_evaluated +10444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aqueous-exposed helices and loops,False,no_term_above_threshold +10445,37894,21.87711,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7714844,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR Rossmann helix-loop-β motif,True,assigned_too_few_test_positives +10446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site strand/loop junctions,False,no_term_above_threshold +10447,47529,28.066994,0.9790039,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9790039,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9972389558232931,0.7134322917075866,0.007089056269384138,0.9375,100.63854264900144,12.0,12.0,77.32944228274968,5.687429589869195e-23,Short Ig-like turn motif,True,assigned_and_evaluated +10448,45288,21.165201,1.0,CheY-like superfamily,interpro,85669,3.40.50.2300,0.8564453,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,18.0,18.0,462.17829457364337,1.3033289657798122e-47,Central hydrophobic beta-strand,True,assigned_too_few_test_positives +10449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-LSGGQ NBD helix,False,no_term_above_threshold +10450,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic/Gly-rich α/β core scaffold,False,no_term_above_threshold +10451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding pores and tunnels,False,no_term_above_threshold +10452,58239,31.531387,0.8808594,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8808594,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8035915651781688,0.0749709683414011,0.017722640673460344,,4.2302368886635575,5.0,6.0,29.87622770094207,1.9359859233313678e-07,Charged helical catalytic surfaces,True,assigned_and_evaluated +10453,37894,20.33784,0.99902344,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7597656,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,14.0,14.0,709.7738095238095,3.3915309155506114e-40,SDR YxxxK active-site helix,True,assigned_too_few_test_positives +10454,88160,16.59856,0.79003906,Transmembrane beta strand,keyword,25167,cell outer membrane,0.65625,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,9.0,15.0,173.6533980582524,7.288205501245289e-19,Outer-membrane beta-barrel linkers,True,assigned_too_few_test_positives +10455,27733,18.534054,0.8232422,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,87384,DNA-binding,0.6142578,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8518450040870343,0.21411510589027183,0.0101905183872397,0.08695652173913043,21.011208434536673,9.0,17.0,28.436089030206677,1.198605348333034e-11,Disordered terminal activation domains,True,assigned_and_evaluated +10456,85364,25.566124,0.98828125,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.98828125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,Pocket-flanking helical scaffold,True,assigned_too_few_test_positives +10457,59224,21.62024,0.9243164,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9243164,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9921904761904763,0.216288280545193,0.0031014621178555605,,69.73752131292866,6.0,17.0,48.48549742477636,3.402198909610093e-09,N-terminal amphipathic helix-loop cap,True,assigned_and_evaluated +10458,37894,18.94988,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8613281,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,Rossmann helix-loop-β capping turn,True,assigned_too_few_test_positives +10459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory extensions,False,no_term_above_threshold +10460,46929,17.097492,0.72509766,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.65771484,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.5915630550621669,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,14.0,15.0,80.1819404418828,3.456789292836565e-26,E3 ligase zinc-finger modules,True,assigned_and_evaluated +10461,87882,41.976257,0.89501953,Palmitate,keyword,87882,Palmitate,0.89501953,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9985191766622241,0.4794973544973545,0.002658396101019052,1.0,180.37092151675483,18.0,20.0,59.954078212290504,9.18530610399521e-31,Bacterial signal peptide cleavage site,True,assigned_and_evaluated +10462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted surface virulence proteins,False,no_term_above_threshold +10463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ParB/Srx N-terminal CTP-binding motif,False,no_term_above_threshold +10464,85672,17.556051,0.62939453,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.62890625,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5871354244834659,0.04624349435515106,0.01595037660611431,,2.8992101877659984,9.0,13.0,27.702065049044915,5.283466418340588e-12,ABC importer NBD2 motif,True,assigned_and_evaluated +10465,59224,18.252151,0.94921875,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.94921875,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9855238095238095,0.2605141342367547,0.0031014621178555605,0.14285714285714285,83.9972001389079,6.0,17.0,48.48549742477636,3.402198909610093e-09,Catalytic/binding site hotspots,True,assigned_and_evaluated +10466,83302,17.0688,0.6977539,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.6923828,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.7636808872338703,0.10876120356553988,0.004873726185201595,,22.31582149522032,10.0,16.0,128.4935344827586,1.273980298135306e-19,Prokaryotic C-terminal interdomain linkers,True,assigned_and_evaluated +10467,36354,21.05528,0.9453125,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9267578,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,14.0,14.0,214.4640287769784,7.361633030119702e-33,RRM/KH-flanking low-complexity IDRs,True,assigned_too_few_test_positives +10468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic nuclear mixed charge IDRs,False,no_term_above_threshold +10469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved SLiM-docking surfaces,False,no_term_above_threshold +10470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intrinsically disordered regulatory regions,False,no_term_above_threshold +10471,37312,18.16001,0.9975586,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",0.9975586,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,15.0,0.0,1.0,CA-domain β–α hinge,True,assigned_too_few_test_positives +10472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electrostatic nucleoprotein interface patches,False,no_term_above_threshold +10473,88163,18.345932,0.71533203,Transposable element,keyword,88163,Transposable element,0.71533203,122,keywords,Transposable element,keyword:keywords:Transposable element,11.0,2257.0,0.783635554116409,0.04292962014751515,0.004873726185201595,,8.808377515721972,4.0,14.0,73.74273345701917,4.1693226736573504e-07,Trp-centered retroelement Pol motifs,True,assigned_and_evaluated +10474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal N-terminal regulatory tails,False,no_term_above_threshold +10475,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leucine-rich membrane-proximal hydrophobic segment,False,no_term_above_threshold +10476,58239,21.137577,0.6010742,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6010742,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.5661479476770409,0.11738131774317298,0.017722640673460344,0.1,6.623240853658536,15.0,18.0,29.87622770094207,9.071905315818365e-21,RecF/OLD central/dimerization region,True,assigned_and_evaluated +10477,87991,18.564285,0.83984375,Pyrrolidone carboxylic acid,keyword,87991,Pyrrolidone carboxylic acid,0.83984375,223,keywords,Pyrrolidone carboxylic acid,keyword:keywords:Pyrrolidone carboxylic acid,11.0,2257.0,0.833684125313689,0.02261139570656044,0.004873726185201595,,4.639447282700629,0.0,18.0,0.0,1.0,Helical glutamine interface signal,True,assigned_and_evaluated +10478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helix-loop modules,False,no_term_above_threshold +10479,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed linker loops,False,no_term_above_threshold +10480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tandem CBS regulatory domains,False,no_term_above_threshold +10481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal GIY-YIG flanking activation,False,no_term_above_threshold +10482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal CoA groove scaffold,False,no_term_above_threshold +10483,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/aliphatic low-complexity stretches,False,no_term_above_threshold +10484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix caps and TM boundaries,False,no_term_above_threshold +10485,50806,15.969265,0.90478516,"Homeobox, conserved site",interpro,87566,Homeobox,0.8754883,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,Phosphate and metal-binding catalytic loop,True,assigned_too_few_test_positives +10486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-flanking lid loops,False,no_term_above_threshold +10487,27733,19.45726,0.8847656,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.6894531,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.9538067805846405,0.17864572833989287,0.0101905183872397,,17.530582994049485,6.0,20.0,16.11378378378378,2.4394936272431996e-06,Nuclear regulatory low-complexity IDRs,True,assigned_and_evaluated +10488,48767,17.369223,0.9995117,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.8979492,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,5.0,20.0,232.89453124999997,3.9827033559169014e-11,Short interfacial binding/catalytic hotspot,True,assigned_too_few_test_positives +10489,88058,20.615839,0.625,Signal,keyword,88058,Signal,0.625,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.628671545492845,0.11027392176820465,0.09127159946832078,,1.2081953467516402,4.0,19.0,1.5168325647956749,0.4167641580369206,S/T/P-rich disordered regulatory regions,True,assigned_and_evaluated +10490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity terminal tails,False,no_term_above_threshold +10491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane beta-barrel loops,False,no_term_above_threshold +10492,84152,27.674719,0.95410156,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.95410156,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,Metalloenzyme active site helix,True,assigned_too_few_test_positives +10493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-centered hydrophobic peaks,False,no_term_above_threshold +10494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Edge-of-domain interaction segments,False,no_term_above_threshold +10495,27932,15.912128,0.80908203,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.7519531,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9444398800476522,0.4170054940729082,0.01949490474080638,0.38636363636363635,21.39048636642168,6.0,14.0,44.36086309523809,4.5508450031218226e-09,Amphipathic helical interface patches,True,assigned_and_evaluated +10496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal glycine-rich cofactor-binding core,False,no_term_above_threshold +10497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane transporter loop–helix junctions,False,no_term_above_threshold +10498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-centered catalytic loop-strand,False,no_term_above_threshold +10499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved macromolecular interface detector,False,no_term_above_threshold +10500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix/coiled-coil boundary detector,False,no_term_above_threshold +10501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane anchor helices,False,no_term_above_threshold +10502,88161,34.967995,0.68115234,Transmembrane helix,keyword,88161,Transmembrane helix,0.68115234,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6712119434886873,0.35040557373036724,0.1847585290208241,0.05995203836930456,1.8965596640514122,15.0,15.0,5.4274920345926265,2.044231257442523e-11,Transmembrane anchoring site detector,True,assigned_and_evaluated +10503,52236,17.351803,0.9902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98876953,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,12.0,18.0,148.8664169787765,2.7173132368291117e-24,Alpha-helix C-cap sites,True,assigned_too_few_test_positives +10504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil interfaces,False,no_term_above_threshold +10505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible noncatalytic gating segments,False,no_term_above_threshold +10506,64085,18.76168,0.83251953,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.81152344,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.6283246811510607,0.17077858724349285,0.012405848471422242,0.25,13.765973978877263,2.0,19.0,12.378490605211251,0.01909127601498699,Scaffold interdomain interface region,True,assigned_and_evaluated +10507,81858,18.55473,0.96972656,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6977539,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,16.0,0.0,1.0,Aromatic capped periplasmic TM exits,True,assigned_too_few_test_positives +10508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-solenoid repeats,False,no_term_above_threshold +10509,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic regulatory tails and stalks,False,no_term_above_threshold +10510,63831,16.642036,0.93066406,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.93066406,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9019694950392418,0.019723540022825288,0.002658396101019052,,7.419338305252778,0.0,17.0,0.0,1.0,N-terminal leucine-rich amphipathic helix,True,assigned_and_evaluated +10511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helix-to-beta motif,False,no_term_above_threshold +10512,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface β-hairpin capping patches,False,no_term_above_threshold +10513,88263,16.356041,0.69970703,Zinc-finger,keyword,88263,Zinc-finger,0.69970703,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8859889361238282,0.1631906355815293,0.014621178555604785,0.12121212121212122,11.161250439621565,0.0,19.0,0.0,1.0,Eukaryotic repeat interaction scaffolds,True,assigned_and_evaluated +10514,88161,38.902637,0.65527344,Transmembrane helix,keyword,88161,Transmembrane helix,0.65527344,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7098164946303827,0.46187328256253807,0.1847585290208241,0.48201438848920863,2.4998752967473585,12.0,12.0,5.4274920345926265,3.120225285939947e-09,Voltage-sensing S4 helices,True,assigned_and_evaluated +10515,88153,20.027012,0.6713867,Transferase,keyword,88153,Transferase,0.6713867,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8388327267296066,0.27307846987358064,0.052724856003544526,0.008403361344537815,5.179311819366988,3.0,12.0,2.83639391056137,0.13408225019838335,Alpha/beta core helical packing,True,assigned_and_evaluated +10516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic C-terminal capping helix,False,no_term_above_threshold +10517,87326,20.485613,0.62841797,Coiled coil,keyword,87326,Coiled coil,0.62841797,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6782386292964053,0.13085882199767046,0.03943287549844927,0.056179775280898875,3.3185209129072164,12.0,18.0,8.40501867907239,1.4878219757400116e-09,Charged coiled-coil scaffolds,True,assigned_and_evaluated +10518,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Cytochrome b5 heme-binding, acidic loops",False,no_term_above_threshold +10519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inter-TM loop-helix caps,False,no_term_above_threshold +10520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged N-terminal helix/coil linker,False,no_term_above_threshold +10521,64620,16.136984,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7993164,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,14.0,14.0,324.0271739130435,2.279682820657023e-35,HATPase_c G2-box glycine loop,True,assigned_too_few_test_positives +10522,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic ligand-binding N-terminal patches,False,no_term_above_threshold +10523,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc peptidase catalytic pocket,False,no_term_above_threshold +10524,36104,18.081928,0.83203125,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.83203125,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Acidic PEST-like disordered linkers,True,assigned_too_few_test_positives +10525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction surfaces,False,no_term_above_threshold +10526,85649,22.249332,0.7104492,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.70996094,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7544470826359425,0.23178041272620142,0.0101905183872397,0.21739130434782608,22.744712674914634,19.0,19.0,110.61410018552876,7.972136883844738e-39,C-terminal target recognition domain,True,assigned_and_evaluated +10527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thiolase-fold ketoacyl synthase,False,no_term_above_threshold +10528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix capping motifs,False,no_term_above_threshold +10529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-rich disordered C-terminal tails,False,no_term_above_threshold +10530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal amphipathic basic segment,False,no_term_above_threshold +10531,84991,20.36605,0.9995117,3.30.70.20,gene3d,50754,"4Fe-4S ferredoxin-type, iron-sulphur binding domain",0.97998047,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,8.0,9.0,616.2377260981912,3.3225198090563074e-22,Fe–S non-ligating regions,True,assigned_too_few_test_positives +10532,36535,25.50236,0.95751953,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9501953,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9472630173564752,0.4617228972966678,0.004430660168365086,0.9,104.21085791985793,0.0,18.0,0.0,1.0,HATPase_c N-box helix hydrophobics,True,assigned_and_evaluated +10533,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C juxtamembrane boundary motif,False,no_term_above_threshold +10534,64016,24.360113,0.7290039,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.72558594,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.49422222222222223,0.0031014621178555605,0.0031014621178555605,,1.0,0.0,17.0,0.0,1.0,Post-Cys redox capping loops,True,assigned_and_evaluated +10535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small polar beta-barrel strands,False,no_term_above_threshold +10536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane and juxtamembrane helices,False,no_term_above_threshold +10537,37341,21.881397,0.9970703,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9941406,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9978408902175718,0.8036340089259488,0.011962782454585734,1.0,67.17785030169875,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 blade boundary loops,True,assigned_and_evaluated +10538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-access cap/lid subdomains,False,no_term_above_threshold +10539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helices and loops,False,no_term_above_threshold +10540,85649,21.604012,0.9555664,Vaccinia Virus protein VP39,gene3d,88153,Transferase,0.68603516,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9364952707173719,0.5431929074772831,0.0101905183872397,0.7391304347826086,53.303756181575125,11.0,11.0,110.61410018552876,8.372133250060158e-23,Recurring amphipathic beta-strand motif,True,assigned_and_evaluated +10541,37894,17.98604,1.0,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.94970703,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,16.0,16.0,709.7738095238095,1.3714649252219745e-45,SDR Rossmann N-cap glycine motif,True,assigned_too_few_test_positives +10542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic C-terminal stability lobe,False,no_term_above_threshold +10543,50806,16.459362,0.96728516,"Homeobox, conserved site",interpro,87384,DNA-binding,0.60302734,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,16.0,16.0,285.26794258373207,2.273102860205199e-39,Transcription factor disordered flanks,True,assigned_too_few_test_positives +10544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short acidic loop caps,False,no_term_above_threshold +10545,55054,28.841915,1.0,HAD superfamily,interpro,55054,HAD superfamily,1.0,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8934724689165187,0.43710973268350317,0.002215330084182543,0.6,197.31133333333335,13.0,15.0,290.28951310861424,4.040725274098586e-31,Active site proximal specificity helix,True,assigned_and_evaluated +10546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered regulatory tails,False,no_term_above_threshold +10547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic DE-rich disordered segments,False,no_term_above_threshold +10548,88161,85.77795,0.8886719,Transmembrane helix,keyword,88161,Transmembrane helix,0.8886719,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.9324927014909812,0.8165484347520822,0.1847585290208241,0.9256594724220624,4.419543926224099,19.0,19.0,5.4274920345926265,2.5090631899926267e-14,Alpha-helical transmembrane segments,True,assigned_and_evaluated +10549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intein/HINT and LAGLIDADG domains,False,no_term_above_threshold +10550,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical scaffolds,False,no_term_above_threshold +10551,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat-rich beta-turn motifs,False,no_term_above_threshold +10552,88164,17.977684,0.7841797,Transposition,keyword,46274,Ribonuclease H-like superfamily,0.7290039,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8982238010657194,0.7604430660168366,0.002215330084182543,0.8,343.26400000000007,2.0,15.0,96.94471544715446,0.000350293891878199,Contiguous structured hydrophobic-aromatic mid/C-terminal segments,True,assigned_and_evaluated +10553,87882,21.140215,0.8671875,Palmitate,keyword,88058,Signal,0.85302734,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9357322671405301,0.0409494788785281,0.002658396101019052,,15.403828971472986,5.0,18.0,18.504345127250154,1.031309184113659e-05,Membrane-targeting signal helices,True,assigned_and_evaluated +10554,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal FnIII/PKD beta-strand activation,False,no_term_above_threshold +10555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue helix-boundary/cleavage motifs,False,no_term_above_threshold +10556,85682,16.712677,0.8671875,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7729492,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9705465949820788,0.1695984000336251,0.011076650420912717,,15.311343555035675,0.0,20.0,0.0,1.0,Helix termini and linkers,True,assigned_and_evaluated +10557,85364,26.838976,0.9394531,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9394531,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,18.0,301.1161616161616,2.0260096530472245e-44,Extracytoplasmic oxyanion-binding loops,True,assigned_too_few_test_positives +10558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"THAP C-terminus, SLiM-rich tails",False,no_term_above_threshold +10559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic and lumenal glycoprotein domains,False,no_term_above_threshold +10560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure capping linkers,False,no_term_above_threshold +10561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted beta-propeller segments,False,no_term_above_threshold +10562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural alpha helices,False,no_term_above_threshold +10563,36535,18.958036,0.92626953,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8857422,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9185135736537605,0.16372254894661328,0.004430660168365086,,36.95217929725062,0.0,17.0,0.0,1.0,Active site connector loop,True,assigned_and_evaluated +10564,25169,23.053436,0.89746094,pilus,go_cc,25169,pilus,0.89746094,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8976021314387211,0.8004430660168367,0.002215330084182543,0.8,361.3200000000001,18.0,19.0,522.9912280701753,8.320203081731553e-48,Surface-exposed interaction patch,True,assigned_and_evaluated +10565,42054,18.146141,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,17.0,17.0,677.5113636363636,6.533334885052963e-48,Radical SAM C-terminal catalytic surface,True,assigned_too_few_test_positives +10566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic residues in DNA-binding helices,False,no_term_above_threshold +10567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cys-rich ectodomain stalks,False,no_term_above_threshold +10568,37468,21.291119,0.99609375,"Zinc finger, RING-type",interpro,88263,Zinc-finger,0.86816406,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,15.0,18.0,114.47964669738863,1.9694884733107572e-29,E3 RING zinc finger,True,assigned_too_few_test_positives +10569,36876,16.284973,0.93652344,Cytochrome P450,interpro,36876,Cytochrome P450,0.93652344,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9916963226571768,0.214891462167004,0.003987594151528578,,53.89000334565867,0.0,18.0,0.0,1.0,Short interfacial TM helices,True,assigned_and_evaluated +10570,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-active-site scaffold signal,False,no_term_above_threshold +10571,88263,21.487333,0.78222656,Zinc-finger,keyword,88263,Zinc-finger,0.78222656,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9224983649444082,0.09989036971565224,0.014621178555604785,,6.831895892370518,4.0,17.0,6.131324557795145,0.005951082834709425,Beta-sandwich anion-binding interface,True,assigned_and_evaluated +10572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-binding catalytic core,False,no_term_above_threshold +10573,38654,22.743052,0.9873047,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9868164,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,18.0,0.0,1.0,Conserved SET/PR catalytic core,True,assigned_too_few_test_positives +10574,87326,38.632385,0.75,Coiled coil,keyword,87326,Coiled coil,0.75,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.769714747709275,0.4140179249220098,0.03943287549844927,0.4157303370786517,10.499308500550294,14.0,14.0,12.607528018608585,9.085680317979921e-16,Coiled-coil oligomerization interfaces,True,assigned_and_evaluated +10575,37894,17.315935,0.95996094,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.81152344,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,12.0,12.0,709.7738095238095,1.3370599170917052e-34,SDR YXXXK catalytic helix,True,assigned_too_few_test_positives +10576,38873,18.76268,0.80371094,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7265625,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.6925399644760213,0.09847205519336667,0.002215330084182543,,44.45028571428572,7.0,19.0,63.11963097398669,2.2171377393875897e-11,Basic N-terminal assembly tail,True,assigned_and_evaluated +10577,45324,15.853273,0.7714844,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.7714844,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9985790408525755,0.4553968253968254,0.002215330084182543,1.0,205.566126984127,9.0,17.0,289.57852131678356,1.0345399949928525e-20,Surface beta-solenoid repeats,True,assigned_and_evaluated +10578,48255,16.507801,0.9423828,Rossmann-like alpha/beta/alpha sandwich fold,interpro,87525,Glycosyltransferase,0.7841797,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,3.0,15.0,68.13828571428571,2.054633119852229e-05,N-terminal core beta-strand scaffold,True,assigned_too_few_test_positives +10579,52236,22.90022,0.9946289,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.94140625,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR inter-repeat linker residues,True,assigned_too_few_test_positives +10580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-loop surface patches,False,no_term_above_threshold +10581,37894,19.120247,0.9794922,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9794922,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,13.0,709.7738095238095,2.0554498274794366e-37,SDR active site helix,True,assigned_too_few_test_positives +10582,81685,16.470266,0.9580078,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9267578,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9353934669636227,0.22475446222605394,0.005316792202038104,,42.27256843701698,1.0,15.0,5.710823754789272,0.25652536366738904,Beta-sheet entry points,True,assigned_and_evaluated +10583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IAPP motif and signal-peptide detector,False,no_term_above_threshold +10584,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecG Wedge domain segment,False,no_term_above_threshold +10585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Charged peripheral stalks, ion-binding carboxylates",False,no_term_above_threshold +10586,49061,32.042343,0.9291992,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9291992,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.700273985771967,0.14042902991844786,0.012405848471422242,,11.319582875926315,7.0,19.0,36.42724971633062,9.833284897922131e-10,Beta-propeller/solenoid interaction loops,True,assigned_and_evaluated +10587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich catalytic hinges,False,no_term_above_threshold +10588,87384,16.222332,0.640625,DNA-binding,keyword,87384,DNA-binding,0.640625,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.5921213993503149,0.05105920072801094,0.043863535666814356,,1.1640466266981888,8.0,18.0,5.444467273931009,7.473215523729393e-05,Short structured functional hotspots,True,assigned_and_evaluated +10589,82029,30.443304,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9951172,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS periplasmic TM3/TM9 termini,True,assigned_too_few_test_positives +10590,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated low-complexity IDRs,False,no_term_above_threshold +10591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta/coil-rich segments,False,no_term_above_threshold +10592,46284,16.18086,0.9736328,FMN-binding split barrel,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.97216797,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,15.0,0.0,1.0,Edge coil-to-beta transitions,True,assigned_too_few_test_positives +10593,37446,16.116598,0.87939453,F-box domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7890625,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.8466031746031746,0.010970375935615732,0.0031014621178555605,,3.537162640954958,0.0,16.0,0.0,1.0,Alpha-helix C-cap motif,True,assigned_and_evaluated +10594,88009,24.298712,0.6254883,Repeat,keyword,88009,Repeat,0.6254883,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7166877396198711,0.2697901075149727,0.07266282676118742,0.32926829268292684,3.712904101593252,14.0,19.0,6.532529837605165,7.391597730719461e-10,Hydrophobic secondary-structure segments,True,assigned_and_evaluated +10595,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered flanking linkers,False,no_term_above_threshold +10596,85649,42.21168,0.92578125,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.91845703,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9107858783231482,0.742902468728731,0.0101905183872397,0.782608695652174,72.90134225742372,17.0,17.0,110.61410018552876,7.110790058883305e-35,Rossmann-like MTase catalytic lobe,True,assigned_and_evaluated +10597,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear regulatory interaction domains,False,no_term_above_threshold +10598,43626,16.829994,0.8754883,Putative DNA-binding domain superfamily,interpro,43626,Putative DNA-binding domain superfamily,0.8754883,26,ip,IPR009061,interpro:ip:IPR009061,5.0,2257.0,0.9988454706927176,0.5392857142857144,0.002215330084182543,1.0,243.43357142857147,12.0,19.0,597.7042606516289,1.3241668655890508e-31,Tail/loop interaction patch,True,assigned_and_evaluated +10599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal functional domain core,False,no_term_above_threshold +10600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta-strand preference,False,no_term_above_threshold +10601,36272,15.571103,0.9794922,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9794922,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,2.0,9.0,308.1188630490956,3.384655682073914e-05,Nucleotide catalytic core activation,True,assigned_too_few_test_positives +10602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical scaffolds,False,no_term_above_threshold +10603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-peptide-flanking disordered linker,False,no_term_above_threshold +10604,87882,23.563105,0.7783203,Palmitate,keyword,88058,Signal,0.69140625,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.8163038649489116,0.07985802147067873,0.002658396101019052,,30.039925743220316,0.0,19.0,0.0,1.0,Signal peptidase I cleavage site,True,assigned_and_evaluated +10605,85656,22.337656,0.6738281,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.6738281,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.7831428571428573,0.42990062662193806,0.0031014621178555605,0.42857142857142855,138.61224489795916,10.0,10.0,141.281990521327,7.760530161277081e-22,S10 carboxypeptidase ectodomain activation,True,assigned_and_evaluated +10606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular calcium-binding cysteine-rich repeats,False,no_term_above_threshold +10607,49061,16.447021,0.8144531,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8144531,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.929164263282702,0.11193187414135637,0.012405848471422242,,9.022508569180047,0.0,16.0,0.0,1.0,Acidic beta-alpha N-cap loop,True,assigned_and_evaluated +10608,63951,16.856792,0.7949219,Immunoglobulin-like domain superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.7949219,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8788058521154606,0.2630386091861502,0.003987594151528578,0.2222222222222222,65.96423788146011,0.0,17.0,0.0,1.0,Motif-rich cytosolic IDRs,True,assigned_and_evaluated +10609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal basic nucleic-acid-binding surfaces,False,no_term_above_threshold +10610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity SLiM-rich IDRs,False,no_term_above_threshold +10611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SGNH cap O-acetylation loop,False,no_term_above_threshold +10612,83419,17.798952,0.92089844,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.8666992,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,2.0,16.0,45.44283536585366,0.001549786756693017,Beta-strand glycan/receptor interfaces,True,assigned_too_few_test_positives +10613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PA/EIIA-like β-sandwich module,False,no_term_above_threshold +10614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal nucleic-acid tails/motifs,False,no_term_above_threshold +10615,81858,18.693678,0.9580078,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.72802734,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Generic transmembrane alpha-helices,True,assigned_too_few_test_positives +10616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAP10 O-glucosyltransferase catalytic core,False,no_term_above_threshold +10617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic glycan-binding groove,False,no_term_above_threshold +10618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-catalytic N-terminal interaction domain,False,no_term_above_threshold +10619,64058,21.477543,0.7001953,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.68896484,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7107668301382079,0.2822452391883443,0.006202924235711121,0.21428571428571427,45.501964632006654,18.0,18.0,113.99808795411089,4.371993551442556e-37,C-terminal helix-loop active-site interface,True,assigned_and_evaluated +10620,45290,19.164417,0.72558594,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.72558594,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.723124914301385,0.17977391247451646,0.0057598582188746125,0.07692307692307693,31.211516958075663,17.0,17.0,73.42487684729065,6.829036441178294e-32,C-lobe scaffold helix activation,True,assigned_and_evaluated +10621,25167,18.649292,0.6738281,cell outer membrane,go_cc,25167,cell outer membrane,0.6738281,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.8315515961395694,0.6684389307340127,0.005316792202038104,0.6666666666666666,125.72222222222221,12.0,17.0,96.3052900794185,3.409132180565012e-22,Outer-membrane β-barrel initiation,True,assigned_and_evaluated +10622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix assembly motifs,False,no_term_above_threshold +10623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broadly activated small nuclear regulators,False,no_term_above_threshold +10624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity N-termini,False,no_term_above_threshold +10625,39971,15.801208,0.73828125,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.72509766,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,14.0,0.0,1.0,Phosphoesterase beta-sheet scaffold,True,assigned_too_few_test_positives +10626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand aliphatic packing signal,False,no_term_above_threshold +10627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical oligomerization interfaces,False,no_term_above_threshold +10628,59211,19.18274,0.9946289,Nucleotide-diphospho-sugar transferases,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9091797,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9914695340501792,0.5908339226765372,0.011076650420912717,0.76,53.34048653923778,19.0,19.0,244.34836065573774,4.317107890414195e-45,Glycosyltransferase donor-positioning loop motif,True,assigned_and_evaluated +10629,59224,33.465595,0.9663086,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9663086,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,18.0,18.0,137.37557603686636,1.6332112516921354e-38,Gly-rich hydrolase elbow,True,assigned_and_evaluated +10630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracytoplasmic and membrane domains,False,no_term_above_threshold +10631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic aromatic β–α N-cap loops,False,no_term_above_threshold +10632,49116,15.856108,0.85498047,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.85498047,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9400532859680285,0.021848063472222207,0.002215330084182543,,9.862215851361105,0.0,14.0,0.0,1.0,Helix to coil boundary signal,True,assigned_and_evaluated +10633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane and juxtamembrane helices,False,no_term_above_threshold +10634,52236,24.80748,0.98095703,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.83154297,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,17.0,210.16435338180213,1.624802082425761e-36,TPR/SLR helix register hotspots,True,assigned_too_few_test_positives +10635,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent receptor plug β-strand,False,no_term_above_threshold +10636,36535,16.304844,0.8852539,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8520508,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8947930574098799,0.5700906774882185,0.004430660168365086,0.4,128.66946590909092,9.0,9.0,89.79066265060241,6.179545544344957e-18,Kinase C-terminal regulatory tails,True,assigned_and_evaluated +10637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-dependent phosphoryl transfer,False,no_term_above_threshold +10638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ART/NADase NAD+-entry subdomain,False,no_term_above_threshold +10639,37446,18.11575,0.93603516,F-box domain,interpro,37446,F-box domain,0.93603516,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9303809523809523,0.028950152547595594,0.0031014621178555605,,9.334356328560466,0.0,18.0,0.0,1.0,Helix-capping interhelical turns,True,assigned_and_evaluated +10640,46079,35.928257,0.99853516,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99853516,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9994858083093376,0.923447065754758,0.0057598582188746125,1.0,160.32461749296067,17.0,17.0,93.1578125,1.2704632402379146e-33,TPR repeat register marker,True,assigned_and_evaluated +10641,88263,41.887684,0.9609375,Zinc-finger,keyword,29166,zinc ion binding,0.9199219,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9742410616960976,0.21012006950503104,0.014621178555604785,,14.370939299177426,6.0,18.0,8.686043123543122,7.280569894021822e-05,Archaeal AlaRS N-terminal motif,True,assigned_and_evaluated +10642,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble domain structural cores,False,no_term_above_threshold +10643,82029,31.29655,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,Transporter TM hydrophobic micro-motifs,True,assigned_too_few_test_positives +10644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal NTR/C345C domain,False,no_term_above_threshold +10645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix interfaces and kinks,False,no_term_above_threshold +10646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site glycine-rich loops,False,no_term_above_threshold +10647,37341,25.047928,0.98046875,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9794922,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9963295133698721,0.6604162565095169,0.011962782454585734,1.0,55.20590707192517,2.0,16.0,18.177134146341462,0.009134184335081091,Terminal beta-propeller blade signature,True,assigned_and_evaluated +10648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar/proline-rich low-complexity IDRs,False,no_term_above_threshold +10649,36876,17.336996,0.93310547,Cytochrome P450,interpro,36876,Cytochrome P450,0.93310547,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9947360616844602,0.29697108728548893,0.003987594151528578,,74.4737493337054,0.0,17.0,0.0,1.0,PBP/beta-lactamase catalytic fold,True,assigned_and_evaluated +10650,83419,17.900751,0.9472656,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9042969,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,0.0,20.0,0.0,1.0,Gram-negative outer-membrane beta-barrel motifs,True,assigned_too_few_test_positives +10651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic ligand-binding domains,False,no_term_above_threshold +10652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTP/PPi-binding catalytic lobe,False,no_term_above_threshold +10653,31094,16.942673,0.9584961,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8149414,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9481308411214953,0.5903331320911132,0.004430660168365086,0.8,133.23818791296424,5.0,15.0,236.59126984126982,3.1325478949648654e-11,Acidic-aromatic active-site motifs,True,assigned_and_evaluated +10654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core hydrophobic packing,False,no_term_above_threshold +10655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich alpha/beta core domains,False,no_term_above_threshold +10656,36776,16.146889,0.97998047,SANT/Myb domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9506836,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9863023841255738,0.0974580957793299,0.002658396101019052,,36.66048702899126,0.0,19.0,0.0,1.0,Pre-HTH pre-recognition helix,True,assigned_and_evaluated +10657,36668,16.190481,0.91308594,AMP-dependent synthetase/ligase domain,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.671875,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,16.0,0.0,1.0,Basic cytosolic regulatory linkers,True,assigned_too_few_test_positives +10658,64016,20.773607,0.69921875,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.6953125,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9255873015873016,0.5272828928566633,0.0031014621178555605,0.8571428571428571,170.01106988249845,14.0,15.0,206.8634448574969,6.533515411716639e-32,GST N-terminal G-site,True,assigned_and_evaluated +10659,37446,21.456121,0.97021484,F-box domain,interpro,63831,F-box-like domain superfamily,0.9692383,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.8317460317460318,0.009956125480872824,0.0031014621178555605,,3.2101393157614235,0.0,14.0,0.0,1.0,Membrane and coiled-coil helix packing,True,assigned_and_evaluated +10660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short conserved catalytic motifs,False,no_term_above_threshold +10661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acyltransferase internal helix motif,False,no_term_above_threshold +10662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PST-rich low-complexity IDRs,False,no_term_above_threshold +10663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured nontransmembrane catalytic cores,False,no_term_above_threshold +10664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-enzyme substrate-binding loops,False,no_term_above_threshold +10665,61392,28.781296,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,14.0,14.0,167.4747191011236,2.3187224721210777e-31,LRR beta-strand loop junctions,True,assigned_and_evaluated +10666,38873,18.104422,0.98828125,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95947266,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9988010657193606,0.6109090909090908,0.002215330084182543,0.8,275.7643636363636,12.0,20.0,102.79482758620689,4.29014189517768e-22,Pre-P-loop beta1 strand,True,assigned_and_evaluated +10667,36668,16.908236,0.9692383,AMP-dependent synthetase/ligase domain,interpro,48241,RmlC-like jelly roll fold,0.9550781,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,19.0,0.0,1.0,Structured domains and anion-binding residues,True,assigned_too_few_test_positives +10668,85364,27.716972,0.9873047,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9873047,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,Venus flytrap ligand-binding domains,True,assigned_too_few_test_positives +10669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane beta-barrel detector,False,no_term_above_threshold +10670,87913,15.641749,0.76708984,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.76708984,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8099324883765365,0.12426693659431169,0.006202924235711121,,20.03360542095439,0.0,15.0,0.0,1.0,N-terminal GATase module,True,assigned_and_evaluated +10671,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptide extracytoplasmic domains,False,no_term_above_threshold +10672,81540,15.603344,1.0,"Tetracycline Repressor, domain 2",gene3d,81540,"Tetracycline Repressor, domain 2",1.0,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,20.0,20.0,828.0694444444445,2.4307463492151184e-57,Helical hydrophobic ligand-binding pocket,True,assigned_too_few_test_positives +10673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic juxtamembrane donor-binding helices,False,no_term_above_threshold +10674,37007,20.117306,0.98046875,Metallo-beta-lactamase,interpro,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.97216797,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,14.0,16.0,724.5607638888889,3.352702967241692e-39,Metallo-beta-lactamase HxHxD motif,True,assigned_too_few_test_positives +10675,36914,23.114405,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9326172,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,14.0,14.0,736.0617283950618,1.9996289063569166e-40,Glycosyltransferase donor-binding core,True,assigned_too_few_test_positives +10676,81858,16.071615,0.7426758,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.7426758,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,12.0,0.0,1.0,Aromatic anchored TM packing helices,True,assigned_too_few_test_positives +10677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal amphipathic helix-tail,False,no_term_above_threshold +10678,39177,16.504345,0.99609375,Fibronectin type III,interpro,47529,Immunoglobulin-like fold,0.95654297,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,15.0,16.0,273.9935661764706,5.4350614151811805e-36,Hydrophobic Ig/FN3 beta-strands,True,assigned_too_few_test_positives +10679,-1,,,,,-1,,,0,,,,,,,,,,,,,,,T-fold pterin biosynthesis enzymes,False,no_term_above_threshold +10680,36886,20.6767,1.0,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.8027344,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9996665184526455,0.875545634920635,0.003544528134692069,1.0,247.01331225198416,19.0,19.0,233.80784313725488,9.641649479262281e-45,Zn2Cys6 DBD with basic tail,True,assigned_and_evaluated +10681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and signal peptides,False,no_term_above_threshold +10682,64155,18.04077,0.79785156,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.76123047,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,13.0,14.0,257.4993355481728,6.684006324971496e-31,DEDD exonuclease C-terminal extensions,True,assigned_too_few_test_positives +10683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long noncatalytic recognition interfaces,False,no_term_above_threshold +10684,64016,40.637707,0.98535156,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.97802734,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9991111111111111,0.7306122448979591,0.0031014621178555605,1.0,235.5702623906705,17.0,17.0,221.63940520446096,6.597242864343111e-40,Thioredoxin-like redox modules,True,assigned_and_evaluated +10685,88164,15.613253,0.7026367,Transposition,keyword,88164,Transposition,0.7026367,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.8988898756660746,0.7604430660168364,0.002215330084182543,0.8,343.264,2.0,18.0,80.78726287262872,0.0005061710321082204,Diffuse mid-sequence catalytic activation,True,assigned_and_evaluated +10686,85388,16.019276,0.8598633,Glutaredoxin,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.82666016,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.8531847487772344,0.017652487141102534,0.003544528134692069,,4.980207934683553,0.0,16.0,0.0,1.0,CheY-like receiver domain and mimics,True,assigned_and_evaluated +10687,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long charged helical stalks,False,no_term_above_threshold +10688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long charged interaction surfaces,False,no_term_above_threshold +10689,25169,22.735912,0.7290039,pilus,go_cc,25169,pilus,0.7290039,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8983570159857904,0.34472878030255083,0.002215330084182543,0.8,155.61057142857146,1.0,17.0,32.473311546840954,0.05052623496021244,Residue-level polar/acidic micro-hotspots,True,assigned_and_evaluated +10690,88161,46.942493,0.62402344,Transmembrane helix,keyword,88161,Transmembrane helix,0.62402344,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6467827911583777,0.38422979672160007,0.1847585290208241,0.36930455635491605,2.0796322570759025,17.0,17.0,5.4274920345926265,7.1365032769983e-13,N-terminal signal-anchor helix,True,assigned_and_evaluated +10691,87326,24.762873,0.62158203,Coiled coil,keyword,87326,Coiled coil,0.62158203,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6578371823044072,0.233919612831488,0.03943287549844927,0.24719101123595505,5.932096248996275,10.0,19.0,6.635541062425571,8.943846718676625e-07,Extended charged coiled-coil scaffolds,True,assigned_and_evaluated +10692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD ATPase core,False,no_term_above_threshold +10693,87913,17.813782,0.99365234,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.99365234,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.9915610470670657,0.38039076998491156,0.006202924235711121,0.9285714285714286,61.32442627542467,0.0,20.0,0.0,1.0,Transglutaminase-like Cys hydrophobic motif,True,assigned_and_evaluated +10694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +10695,88161,43.878925,0.62158203,Transmembrane helix,keyword,88161,Transmembrane helix,0.62158203,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5944459649671568,0.31837515698328367,0.1847585290208241,0.2278177458033573,1.7231959935522092,17.0,19.0,4.856177083582876,7.984635688589255e-11,N-terminal signal-anchor helix,True,assigned_and_evaluated +10696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered polar low-complexity tracts,False,no_term_above_threshold +10697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP23 substrate-binding xxGGF patch,False,no_term_above_threshold +10698,84991,17.690863,0.9350586,3.30.70.20,gene3d,50754,"4Fe-4S ferredoxin-type, iron-sulphur binding domain",0.9189453,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,0.0,9.0,0.0,1.0,Hexapeptide-repeat beta-helix rungs,True,assigned_too_few_test_positives +10699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helix detector,False,no_term_above_threshold +10700,27932,32.723324,0.77001953,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.74853516,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.5601302222404798,0.133503175306454,0.01949490474080638,0.13636363636363635,6.848106060606062,9.0,9.0,103.50868055555556,1.7211418071419026e-18,Basic glycine-rich rRNA-binding segments,True,assigned_and_evaluated +10701,88022,16.388514,0.66308594,Ribosomal protein,keyword,88022,Ribosomal protein,0.66308594,279,keywords,Ribosomal protein,keyword:keywords:Ribosomal protein,50.0,2257.0,0.5211735387403715,0.026502202066413277,0.022153300841825433,,1.1963094012778952,0.0,16.0,0.0,1.0,Periplasmic gate β-strand junctions,True,assigned_and_evaluated +10702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured alpha/beta catalytic pockets,False,no_term_above_threshold +10703,36535,24.46904,0.9501953,Protein kinase domain,interpro,36354,RNA recognition motif domain,0.890625,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8965287049399199,0.737433751081292,0.004430660168365086,0.8,166.43879761904762,6.0,17.0,31.690822111977322,4.1451873667301796e-08,Kinase glycine-rich loop analogs,True,assigned_and_evaluated +10704,87857,19.225237,0.6557617,Nucleus,keyword,87857,Nucleus,0.6557617,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.8516017777420264,0.2052127309122473,0.06247230837394772,,3.2848591040350508,7.0,19.0,2.232279632006846,0.044616680956969974,N-terminal PEST-like IDRs,True,assigned_and_evaluated +10705,38317,22.084944,0.7324219,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7324219,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6338730158730158,0.015905806274658735,0.0031014621178555605,,5.128486394557823,0.0,16.0,0.0,1.0,Effector-binding core helices,True,assigned_and_evaluated +10706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged proline-rich IDR tails,False,no_term_above_threshold +10707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TyrRS anticodon-binding domain,False,no_term_above_threshold +10708,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered low-complexity regions,False,no_term_above_threshold +10709,36535,20.399857,0.91064453,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8803711,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8927903871829106,0.2000994894823246,0.004430660168365086,,45.162454776160665,1.0,17.0,5.281803685329553,0.2747445817987687,PAC β-strand capping motif,True,assigned_and_evaluated +10710,64058,20.202421,0.9350586,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.92333984,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.991959110884657,0.5144878284867265,0.006202924235711121,0.6428571428571429,82.94278777818154,13.0,18.0,82.33195241130231,3.6669188501821225e-23,TMADH-like dual-loop signature,True,assigned_and_evaluated +10711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helical assembly motifs,False,no_term_above_threshold +10712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature N-terminal hydrophobic beta-strand,False,no_term_above_threshold +10713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topo IA active-site motif,False,no_term_above_threshold +10714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide-rich luminal ectodomains,False,no_term_above_threshold +10715,87857,27.722628,0.7216797,Nucleus,keyword,87857,Nucleus,0.7216797,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.731904168174932,0.21415182520851178,0.06247230837394772,0.03546099290780142,3.427948010607171,19.0,19.0,6.059044715447154,3.151619808492605e-15,Mixed-charge low-complexity IDRs,True,assigned_and_evaluated +10716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topoisomerase B C-terminal motif,False,no_term_above_threshold +10717,36776,17.474459,0.9916992,SANT/Myb domain,interpro,80926,Homeodomain-like,0.89160156,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9926699244780097,0.16390674069702205,0.002658396101019052,,61.656252292196456,1.0,18.0,17.712715389185977,0.0904919722408984,HTH recognition helix,True,assigned_and_evaluated +10718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site glycine-rich loops,False,no_term_above_threshold +10719,69990,15.712659,0.93652344,DNA/RNA polymerase superfamily,interpro,87856,Nucleotidyltransferase,0.77978516,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.8469206349206351,0.1491617557809949,0.0031014621178555605,,48.09401182824364,5.0,16.0,82.0773678414097,6.581175712676194e-09,Helical nucleotidyltransferase interaction scaffolds,True,assigned_and_evaluated +10720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD-oxidoreductase helical scaffold,False,no_term_above_threshold +10721,36010,16.483053,0.99560547,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97265625,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,17.0,19.0,455.9410706252812,7.976975571869202e-44,Oxyanion-stabilizing glycine loops,True,assigned_too_few_test_positives +10722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial periplasmic coiled-coil stalks,False,no_term_above_threshold +10723,46933,17.19233,0.70751953,"Zinc finger, NHR/GATA-type",interpro,46933,"Zinc finger, NHR/GATA-type",0.70751953,49,ip,IPR013088,interpro:ip:IPR013088,,,,,,,,0.0,18.0,0.0,1.0,Internal helical assembly interfaces,True,assigned_too_few_test_positives +10724,59229,29.89221,0.75146484,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.75146484,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7768771164999415,0.3644005614426141,0.0101905183872397,0.4782608695652174,35.75878552939044,12.0,13.0,98.10119292472234,1.5893007827992264e-23,Class I SAM methyltransferase module,True,assigned_and_evaluated +10725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic tails/linkers,False,no_term_above_threshold +10726,85656,33.97108,0.9760742,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.97558594,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9992380952380953,0.8626373626373625,0.0031014621178555605,1.0,278.1389324960753,17.0,17.0,141.281990521327,1.2016016738676925e-36,Alpha/beta hydrolase His-loop,True,assigned_and_evaluated +10727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxyanion-loop activation signature,False,no_term_above_threshold +10728,45317,20.66114,0.8852539,"Six-bladed beta-propeller, TolB-like",interpro,45317,"Six-bladed beta-propeller, TolB-like",0.8852539,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,11.0,16.0,525.505608974359,1.3855834520117531e-28,Beta-propeller blade catalytic loops,True,assigned_too_few_test_positives +10729,38873,20.92739,0.9873047,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.95751953,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9980461811722914,0.7158333333333333,0.002215330084182543,0.6,323.1271666666667,16.0,16.0,171.32471264367817,7.059051418617812e-36,ABC NBD P-loop helix,True,assigned_and_evaluated +10730,85649,36.85087,0.8251953,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8173828,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8014869020279476,0.5764351948599988,0.0101905183872397,0.6086956521739131,56.565836295609444,20.0,20.0,110.61410018552876,8.965631807545709e-41,C-terminal SAM lid helix,True,assigned_and_evaluated +10731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short motifs in structured/disordered regions,False,no_term_above_threshold +10732,82029,25.082104,0.9995117,MFS general substrate transporter like domains,gene3d,88162,Transport,0.6191406,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,20.0,169.27097791798107,9.692152584541787e-39,Transmembrane helix core residues,True,assigned_too_few_test_positives +10733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic acidic groove-lining loops,False,no_term_above_threshold +10734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long protein interior segments,False,no_term_above_threshold +10735,64016,30.94522,0.8383789,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.83691406,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7821904761904762,0.34259903932035074,0.0031014621178555605,0.42857142857142855,110.46371882086166,9.0,9.0,221.63940520446096,1.8301109131092664e-21,N-terminal targeting signals,True,assigned_and_evaluated +10736,85364,16.658838,0.75341797,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.75341797,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Aromatic glycine-rich binding clefts,True,assigned_too_few_test_positives +10737,64058,21.06485,0.6738281,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.66748047,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.5695178651041334,0.14817393505918097,0.006202924235711121,0.14285714285714285,23.887755102040817,13.0,13.0,113.99808795411089,5.118200968948955e-27,C-terminal amphipathic helical cap,True,assigned_and_evaluated +10738,39958,18.123604,0.9770508,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.9770508,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,1.0,1.0,0.002658396101019052,1.0,376.16666666666663,17.0,18.0,446.89462081128744,3.4883256896771764e-44,Acidic IDR activation domains,True,assigned_and_evaluated +10739,8305,16.426134,0.76660156,fatty acid biosynthetic process,go_bp,8305,fatty acid biosynthetic process,0.76660156,31,go,GO:0006633,go_bp:go:GO:0006633,9.0,2257.0,0.9999011466982998,0.9765432098765432,0.003987594151528578,1.0,244.89533607681756,13.0,15.0,243.73364779874214,3.9741504984627736e-30,Active-site helical lid,True,assigned_and_evaluated +10740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short small-residue motifs,False,no_term_above_threshold +10741,37071,17.97702,0.97998047,Homeodomain,interpro,87384,DNA-binding,0.6665039,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,15.0,15.0,206.30103806228374,6.806087802396642e-35,Upstream disordered linker activation,True,assigned_too_few_test_positives +10742,85664,17.228031,0.9350586,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7890625,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,13.0,0.0,1.0,Flavodoxin-like N-terminal lid activation,True,assigned_too_few_test_positives +10743,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase interdomain coupling hinge,False,no_term_above_threshold +10744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB/TolA periplasmic proline-rich linker,False,no_term_above_threshold +10745,59224,33.229244,0.9814453,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9814453,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Hydrolase core beta-strand scaffold,True,assigned_and_evaluated +10746,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type II periplasmic juxtamembrane linker,False,no_term_above_threshold +10747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Termini and proteolytic cleavage sites,False,no_term_above_threshold +10748,88009,21.39763,0.65283203,Repeat,keyword,88009,Repeat,0.65283203,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7137147052311421,0.1832971253543907,0.07266282676118742,,2.5225708044198765,6.0,19.0,2.799655644687928,0.02568930739739356,Disordered alanine-rich tandem repeats,True,assigned_and_evaluated +10749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature domain boundary detector,False,no_term_above_threshold +10750,36115,17.584137,0.9975586,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9970703,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,16.0,19.0,311.8457012095456,2.4909173293642985e-38,C-terminal helical assembly modules,True,assigned_too_few_test_positives +10751,46078,24.242432,0.9267578,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9135742,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,6.0,20.0,39.224342105263155,1.3837665853052419e-08,Alpha-solenoid amphipathic helices,True,assigned_too_few_test_positives +10752,87413,19.06391,0.640625,Disulfide bond,keyword,87413,Disulfide bond,0.640625,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5701523321252835,0.09010924627891578,0.0717766947275144,,1.2554109188364995,0.0,20.0,0.0,1.0,Short solvent-exposed connector loops,True,assigned_and_evaluated +10753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic juxtamembrane stalks and linkers,False,no_term_above_threshold +10754,63774,16.827026,0.93066406,RNA-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.92041016,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,16.0,0.0,1.0,Active-site-adjacent scaffold helices,True,assigned_too_few_test_positives +10755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal catalytic-core stabilizer,False,no_term_above_threshold +10756,27936,16.836096,0.80029297,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.80029297,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,10.0,13.0,493.14309346567416,4.635942348593012e-26,PPIase catalytic pocket loops,True,assigned_too_few_test_positives +10757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Near-global C-terminal core peaks,False,no_term_above_threshold +10758,87317,17.368622,0.6010742,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.6010742,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.559711066488175,0.025647368680155568,0.007089056269384138,,3.617881944444445,1.0,12.0,7.037417374881964,0.21292932409858378,Secreted histidine metal enzymes,True,assigned_and_evaluated +10759,88161,22.26113,0.61865234,Transmembrane helix,keyword,88161,Transmembrane helix,0.61865234,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6925907100406631,0.3529795683276026,0.1847585290208241,0.1223021582733813,1.910491332650837,4.0,20.0,1.0854984069185254,0.8023243128614754,Hydrophobic transmembrane helix detector,True,assigned_and_evaluated +10760,87149,25.49087,0.7548828,Amphibian defense peptide,keyword,87162,Antimicrobial,0.67333984,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8751201691982311,0.22602153686991322,0.012405848471422242,,18.218950311264077,0.0,19.0,0.0,1.0,Membrane-proximal amphipathic hydrophobic segments,True,assigned_and_evaluated +10761,88263,23.15093,0.77490234,Zinc-finger,keyword,88263,Zinc-finger,0.77490234,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8690116088947025,0.16669346219587178,0.014621178555604785,,11.400822550790382,2.0,20.0,2.6058129370629373,0.28173901303733356,SH3 tryptophan ligand groove,True,assigned_and_evaluated +10762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion/metal-binding micro-sites,False,no_term_above_threshold +10763,64016,15.856831,0.61621094,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.61621094,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7098412698412698,0.11092977322485519,0.0031014621178555605,,35.76692830978545,0.0,11.0,0.0,1.0,ABC NBD Q-loop/coupling interface,True,assigned_and_evaluated +10764,36091,17.1286,0.96435547,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.94091797,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,17.0,0.0,1.0,Beta-strand active-site scaffolds,True,assigned_too_few_test_positives +10765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-wall glycan enzyme active site,False,no_term_above_threshold +10766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity IDRs,False,no_term_above_threshold +10767,36914,22.673368,0.9580078,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8647461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,12.0,15.0,588.8493827160494,3.2777973775872965e-32,DolP-GT2 C-terminal cytosolic helix,True,assigned_too_few_test_positives +10768,59218,16.611635,0.9848633,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.9848633,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,9.0,16.0,313.4281542056075,4.144006632736602e-21,Catalytic cleft-capping beta-hairpins,True,assigned_too_few_test_positives +10769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged noncatalytic flanking tails,False,no_term_above_threshold +10770,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-binding enzyme catalytic cores,False,no_term_above_threshold +10771,64620,18.841248,0.98291016,Histidine kinase/HSP90-like ATPase superfamily,interpro,38873,AAA+ ATPase domain,0.7949219,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,19.0,19.0,324.0271739130435,2.7035397615707734e-47,Histidine kinase CA-terminal helix,True,assigned_too_few_test_positives +10772,87162,17.071896,0.6904297,Antimicrobial,keyword,87413,Disulfide bond,0.67578125,669,keywords,Antimicrobial,keyword:keywords:Antimicrobial,56.0,2257.0,0.8604733238138508,0.12316262188265256,0.024811696942844484,,4.963893528377622,0.0,15.0,0.0,1.0,Post-signal bioactive peptide region,True,assigned_and_evaluated +10773,36104,16.532179,0.9770508,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9770508,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,12.0,0.0,1.0,Coil between secondary elements,True,assigned_too_few_test_positives +10774,37312,19.356302,0.9975586,"DNA-binding HTH domain, TetR-type",interpro,64026,MFS transporter superfamily,0.84375,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,9.0,0.0,1.0,ABC NBD coupling loops,True,assigned_too_few_test_positives +10775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent helix/loop patch,False,no_term_above_threshold +10776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal active-site lid,False,no_term_above_threshold +10777,87856,16.616556,0.7480469,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7480469,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.7039832083573672,0.3644604547122111,0.012405848471422242,0.42857142857142855,29.378115938766445,15.0,15.0,84.68892045454545,3.769157467140119e-29,RT/RdRp pre-catalytic region,True,assigned_and_evaluated +10778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cationic low-complexity loops,False,no_term_above_threshold +10779,88164,17.421577,0.9511719,Transposition,keyword,27904,DNA binding,0.60009766,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.9943161634103019,0.35774891774891776,0.002215330084182543,0.2,161.4878614718615,3.0,19.0,114.80295250320924,4.54597246245042e-06,Terminal intrinsically disordered tails,True,assigned_and_evaluated +10780,87413,31.373753,0.64697266,Disulfide bond,keyword,88058,Signal,0.6147461,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6910898965791568,0.21216910547548729,0.0717766947275144,,2.9559609324578693,13.0,20.0,7.687690934338425,1.0108047947283481e-09,Post-signal interaction hotspot,True,assigned_and_evaluated +10781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +10782,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lysine residues and KK/KR motifs,False,no_term_above_threshold +10783,86130,24.34747,0.98095703,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.97509766,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9994920634920634,0.8441043083900226,0.0031014621178555605,1.0,272.16334629089727,18.0,18.0,240.4072580645161,9.531793462767385e-43,Fungal Zn2-Cys6 regulatory domain,True,assigned_and_evaluated +10784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thg1 catalytic core helices,False,no_term_above_threshold +10785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal structural core module,False,no_term_above_threshold +10786,45324,19.225405,0.99609375,Pectin lyase fold/virulence factor,interpro,64507,Ankyrin repeat-containing domain superfamily,0.84814453,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9991119005328597,0.5628571428571428,0.002215330084182543,1.0,254.0737142857143,14.0,17.0,450.4554776038855,7.269594227689697e-36,Glycan-proximal ectodomain loop turns,True,assigned_and_evaluated +10787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PGAM5 catalytic alpha-helix,False,no_term_above_threshold +10788,82029,21.457579,0.9995117,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6738281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS pore-lining TM residues,True,assigned_too_few_test_positives +10789,47531,17.59895,0.7998047,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.7998047,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,16.0,16.0,252.6313559322034,1.5475192822972477e-38,TIM-barrel mouth β1–α1 module,True,assigned_too_few_test_positives +10790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal low-complexity polar IDRs,False,no_term_above_threshold +10791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-Loop Boundary Motifs,False,no_term_above_threshold +10792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic transmembrane helices,False,no_term_above_threshold +10793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved CoA-transferase C-terminal subdomain,False,no_term_above_threshold +10794,72011,16.492435,0.97509766,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.71777344,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,10.0,0.0,1.0,ABC NBD Walker A P-loop,True,assigned_too_few_test_positives +10795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulatory SLiM-rich IDRs,False,no_term_above_threshold +10796,69819,23.584558,0.9560547,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.94873047,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,15.0,18.0,349.88849765258215,1.0140217305442317e-36,ASKHA ATP-binding loop,True,assigned_too_few_test_positives +10797,37690,30.015715,0.9995117,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9995117,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9995555555555555,0.8121315192743763,0.0031014621178555605,1.0,261.85440557175247,17.0,17.0,180.66969696969696,1.989737557278833e-38,ANK repeat helix-loop motif,True,assigned_and_evaluated +10798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Envelope biosynthesis TM helices,False,no_term_above_threshold +10799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Strand-edge active-site rim loops,False,no_term_above_threshold +10800,29034,16.081512,0.6479492,GTP binding,go_mf,29034,GTP binding,0.6479492,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.719132767098793,0.3777769519916532,0.008861320336730172,0.35,42.632129032258064,12.0,12.0,129.6108695652174,1.192992154739222e-25,P-loop Switch I module,True,assigned_and_evaluated +10801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal tail activation,False,no_term_above_threshold +10802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interaction helix,False,no_term_above_threshold +10803,45714,18.884842,0.77734375,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.77734375,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,HAMP-like helical hinge linkers,True,assigned_too_few_test_positives +10804,47529,21.430063,0.8105469,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8105469,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8556587460954932,0.2231103096994445,0.007089056269384138,0.125,31.47249806197789,14.0,18.0,60.14512177547197,2.7100217262699095e-23,TG/GG-centered beta-strand motif,True,assigned_and_evaluated +10805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic regulatory segments,False,no_term_above_threshold +10806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered tails,False,no_term_above_threshold +10807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic pocket junction loops,False,no_term_above_threshold +10808,47717,16.983076,0.9838867,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9838867,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,14.0,273.49082568807336,2.439567240558689e-34,Helicase C-terminal regulatory tails,True,assigned_too_few_test_positives +10809,50338,21.975624,0.9223633,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.86572266,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane helix-loop junctions,True,assigned_too_few_test_positives +10810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar/charged low-complexity regions,False,no_term_above_threshold +10811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flagellar-T3SS switch hydrophobic motif,False,no_term_above_threshold +10812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal interaction scaffold subdomain,False,no_term_above_threshold +10813,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sliding-clamp ring fold,False,no_term_above_threshold +10814,87489,36.07644,0.8701172,GPI-anchor,keyword,87489,GPI-anchor,0.8701172,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8536507936507937,0.3376826688302098,0.0031014621178555605,0.42857142857142855,108.87854050711194,3.0,18.0,24.53539094650206,0.00042351631250505035,C-terminal hydrophobic anchoring signal,True,assigned_and_evaluated +10815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices in lipid metabolism,False,no_term_above_threshold +10816,88038,18.577425,0.60595703,Secreted,keyword,88038,Secreted,0.60595703,3652,keywords,Secreted,keyword:keywords:Secreted,297.0,2257.0,0.4681852538995396,0.12251690352329456,0.13159060700044306,,0.9310459638117031,5.0,16.0,2.508963439267439,0.06634533782111933,Terminal low-complexity interaction tails,True,assigned_and_evaluated +10817,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Calmodulin/centrin-binding IQ helices,False,no_term_above_threshold +10818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MnmE folate-binding subdomain,False,no_term_above_threshold +10819,37430,25.735634,1.0,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,1.0,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,REC upstream helix motif,True,assigned_too_few_test_positives +10820,81739,15.942672,0.8544922,"DNA helicase RuvA subunit, C-terminal domain",gene3d,81739,"DNA helicase RuvA subunit, C-terminal domain",0.8544922,27,gene3d,1.10.8.10,gene3d:gene3d:1.10.8.10,6.0,2257.0,0.9632015400562712,0.03850888062364081,0.002658396101019052,,14.48575726125955,0.0,19.0,0.0,1.0,Short helical activation segments,True,assigned_and_evaluated +10821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular β-propeller detector,False,no_term_above_threshold +10822,39958,25.047998,0.92041016,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.92041016,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.7469643121575597,0.1551170768383883,0.002658396101019052,,58.34987373737373,0.0,17.0,0.0,1.0,Amphipathic domain-boundary hinge helices,True,assigned_and_evaluated +10823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,W2/MA3 helical bundle,False,no_term_above_threshold +10824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ZU5-UPA supramodule marker,False,no_term_above_threshold +10825,38878,15.7819805,0.96777344,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.8925781,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,1.0,18.0,12.405534748231377,0.12651119400753863,Proline-rich interdomain hinges,True,assigned_too_few_test_positives +10826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic low-complexity IDRs,False,no_term_above_threshold +10827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HhH/H2TH NA-binding modules,False,no_term_above_threshold +10828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory disordered and coiled-coil regions,False,no_term_above_threshold +10829,85388,36.9015,0.8227539,Glutaredoxin,gene3d,85388,Glutaredoxin,0.8227539,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.7466096042685638,0.32677226406734605,0.003544528134692069,0.375,92.19062500000001,11.0,11.0,216.80363636363634,5.165684909670471e-26,Thioredoxin-fold beta-alpha motif,True,assigned_and_evaluated +10830,47529,31.169483,0.9682617,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9682617,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9647757697456492,0.6806229877892505,0.007089056269384138,0.875,96.01038021502114,18.0,19.0,73.25947163628916,7.086927814754248e-33,PKD DGxx(S/T)DD motif,True,assigned_and_evaluated +10831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity proline-rich linkers,False,no_term_above_threshold +10832,35372,17.860596,0.96875,ABC-type transporter activity,go_mf,50338,"GPCR, rhodopsin-like, 7TM",0.7553711,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,14.0,0.0,1.0,TM helix N-terminal interface signal,True,assigned_too_few_test_positives +10833,82597,23.213528,0.95458984,Tetratricopeptide repeat domain,gene3d,88009,Repeat,0.6928711,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9393253805018511,0.1362979304628293,0.0057598582188746125,,23.663417619585054,0.0,18.0,0.0,1.0,Ordered secondary structure marker,True,assigned_and_evaluated +10834,36104,23.513878,0.9980469,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9980469,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Amphipathic surface helices,True,assigned_too_few_test_positives +10835,50763,16.296394,0.984375,"Zinc finger, RING-type, conserved site",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.9472656,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,17.0,0.0,1.0,His/Cys coordination/catalytic motifs; disordered tails,True,assigned_too_few_test_positives +10836,46277,22.000116,0.7895508,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.7895508,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.7579940095523354,0.16495933211389885,0.004873726185201595,0.18181818181818182,33.84665568918816,6.0,16.0,70.52957413249212,3.4430525096726335e-10,OB/S1 barrels with acidic tails,True,assigned_and_evaluated +10837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pocket lining residues,False,no_term_above_threshold +10838,37291,16.371284,0.81152344,DnaJ domain,interpro,81330,DnaJ domain,0.8066406,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,6.0,9.0,467.61568627450976,1.3881326931141941e-15,Noncatalytic client-binding adaptor modules,True,assigned_too_few_test_positives +10839,35372,24.48923,0.91748047,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.91748047,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,17.0,0.0,1.0,Aromatic α-glucan-binding loops,True,assigned_too_few_test_positives +10840,85682,20.282799,0.89746094,NAD(P)-binding Rossmann-like Domain,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.8618164,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9734498207885305,0.18054075015005572,0.011076650420912717,,16.29921892354703,0.0,19.0,0.0,1.0,Hydrophobic beta-strand core signal,True,assigned_and_evaluated +10841,37630,20.762342,0.79785156,"von Willebrand factor, type A",interpro,64214,von Willebrand factor A-like domain superfamily,0.7973633,33,ip,IPR002035,interpro:ip:IPR002035,,,,,,,,7.0,20.0,234.46460674157302,2.3302350467596784e-15,Solvent-exposed interaction surfaces,True,assigned_too_few_test_positives +10842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic-domain strand motif,False,no_term_above_threshold +10843,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic helical nucleic-acid engagement surface,False,no_term_above_threshold +10844,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic multiheme cytochrome c domains,False,no_term_above_threshold +10845,87149,19.50026,0.64453125,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.64453125,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6784112029737871,0.12058402144757503,0.012405848471422242,,9.719933443113458,0.0,18.0,0.0,1.0,Secretion/cleavage boundary motifs,True,assigned_and_evaluated +10846,59224,18.085215,0.9350586,Alpha/Beta hydrolase fold,interpro,88261,Zinc,0.7241211,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9622857142857142,0.09642465311663491,0.0031014621178555605,,31.090063154892142,2.0,20.0,13.737557603686636,0.015711742271564955,Histidine active-site metal-binding motif,True,assigned_and_evaluated +10847,37314,17.640047,0.8569336,"Helicase, C-terminal domain-like",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.83691406,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,5.0,5.0,317.1329787234043,6.577292784472141e-13,SF2 RecA2 helicase core,True,assigned_too_few_test_positives +10848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich N-terminal beta-strand motif,False,no_term_above_threshold +10849,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ATP-binding hinge,False,no_term_above_threshold +10850,64026,18.278658,0.83935547,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.65527344,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7759144084110765,0.012736692256302626,0.002658396101019052,,4.791119070412504,0.0,12.0,0.0,1.0,Small-residue TM helix packing,True,assigned_and_evaluated +10851,59211,22.266758,0.9951172,Nucleotide-diphospho-sugar transferases,interpro,64016,Thioredoxin-like superfamily,0.8925781,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9994444444444445,0.9765818181818181,0.011076650420912717,0.96,88.16580654545453,19.0,19.0,244.34836065573774,4.317107890414195e-45,Glycosyltransferase loop-to-beta motif,True,assigned_and_evaluated +10852,38654,20.408773,0.99121094,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99072266,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,19.0,0.0,1.0,Basic-aromatic recognition helix,True,assigned_too_few_test_positives +10853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged IDRs and antiporter Asp,False,no_term_above_threshold +10854,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ordered noncatalytic scaffold residues,False,no_term_above_threshold +10855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,dsRBD alpha1-loop-beta1 hotspot,False,no_term_above_threshold +10856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short domain-boundary linkers,False,no_term_above_threshold +10857,83267,21.229328,0.8286133,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.8286133,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,15.0,0.0,1.0,Ubiquitin-like β-grasp and processing signals,True,assigned_too_few_test_positives +10858,35372,15.713412,0.9946289,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9946289,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,16.0,17.0,660.1633217993079,2.0308627383694374e-44,Transmembrane helix loop hinges,True,assigned_too_few_test_positives +10859,86130,19.022587,0.87158203,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.8696289,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.8927301587301587,0.03346317809004666,0.0031014621178555605,,10.789484707033616,0.0,16.0,0.0,1.0,Nonheme diiron active-site helices,True,assigned_and_evaluated +10860,87276,29.825758,0.61083984,Cell membrane,keyword,25079,plasma membrane,0.60839844,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7041455315328914,0.47261923869344447,0.11120957022596367,0.4342629482071713,4.249807257892845,12.0,13.0,7.57428698469161,2.5740335039473363e-10,Transmembrane helix-loop junctions,True,assigned_and_evaluated +10861,63951,21.640158,0.96777344,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9658203,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9968366943455912,0.47039442039442037,0.003987594151528578,0.8888888888888888,117.96446742557853,0.0,19.0,0.0,1.0,C-terminal beta-sandwich edge strands,True,assigned_and_evaluated +10862,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase cores and cystine-knot peptides,False,no_term_above_threshold +10863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs and signal anchors,False,no_term_above_threshold +10864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C lumenal catalytic motifs,False,no_term_above_threshold +10865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphotransacetylase DAAxV motif,False,no_term_above_threshold +10866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal structured domain core,False,no_term_above_threshold +10867,50869,16.721031,0.9628906,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.9628906,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,19.0,19.0,917.2461538461538,1.6344645258281847e-55,TF N-terminal regulatory domains,True,assigned_too_few_test_positives +10868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site-flanking loop caps,False,no_term_above_threshold +10869,36876,15.64874,0.99560547,Cytochrome P450,interpro,87809,Monooxygenase,0.7871094,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9981217872676947,0.6283950617283951,0.003987594151528578,0.8888888888888888,157.58751714677643,0.0,16.0,0.0,1.0,Active-site glycine-rich helix,True,assigned_and_evaluated +10870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical membrane association modules,False,no_term_above_threshold +10871,45288,18.584465,0.9838867,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9838867,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,18.0,18.0,462.17829457364337,1.3033289657798122e-47,Two-component catalytic β-α N-cap,True,assigned_too_few_test_positives +10872,25167,17.901907,0.68066406,cell outer membrane,go_cc,25167,cell outer membrane,0.68066406,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7854862657757982,0.18727587139472385,0.005316792202038104,,35.22347014482431,18.0,20.0,122.78924485125857,2.7850633119044632e-36,Outer membrane β-barrel strands,True,assigned_and_evaluated +10873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short early anchoring segment,False,no_term_above_threshold +10874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich basic binding loops,False,no_term_above_threshold +10875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic flexible beta/alpha loops,False,no_term_above_threshold +10876,59229,17.724325,0.64501953,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.64501953,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7370674555291736,0.396221177671641,0.0101905183872397,0.4782608695652174,38.881356434995375,14.0,14.0,106.27629233511585,1.2612068461381496e-28,SAM-dependent nucleic-acid MTase domain,True,assigned_and_evaluated +10877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic low-complexity disordered tails,False,no_term_above_threshold +10878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass TM helix-helix interface motifs,False,no_term_above_threshold +10879,37894,15.782072,0.96435547,Short-chain dehydrogenase/reductase SDR,interpro,38317,Pentatricopeptide repeat,0.89501953,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Response regulator output helix,True,assigned_too_few_test_positives +10880,8138,18.824425,0.74902344,translation,go_bp,8138,translation,0.74902344,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.6474641190455226,0.05650066578753279,0.018165706690296855,,3.1102927483527196,6.0,12.0,51.575259515570934,1.4704320500592295e-09,Charged α/β interaction scaffold,True,assigned_and_evaluated +10881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial extracellular surface segments,False,no_term_above_threshold +10882,49116,15.893181,0.7373047,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.7373047,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.7836589698046182,0.034127890275431255,0.002215330084182543,,15.40532967032967,0.0,14.0,0.0,1.0,Noncatalytic terminal/linker recognition segments,True,assigned_and_evaluated +10883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundary signatures,False,no_term_above_threshold +10884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,A1 aspartyl protease N-lobe flap,False,no_term_above_threshold +10885,38317,29.26771,0.99853516,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.99853516,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9961904761904762,0.2995829100871118,0.0031014621178555605,,96.59408972380162,0.0,12.0,0.0,1.0,ABC NBD beta-alpha N-cap,True,assigned_and_evaluated +10886,43643,19.150969,0.92578125,Phosphopantetheine binding ACP domain,interpro,43643,Phosphopantetheine binding ACP domain,0.92578125,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,0.9589675030851501,0.4926117891066123,0.0057598582188746125,0.9230769230769231,85.52498523181723,0.0,17.0,0.0,1.0,PAS cap-loop hinge motif,True,assigned_and_evaluated +10887,87697,17.006674,0.80322266,Knottin,keyword,87413,Disulfide bond,0.6074219,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.853812628609743,0.05474970354690635,0.017279574656623838,,3.1684636129581443,0.0,18.0,0.0,1.0,Phosphoinositide-binding PH loops,True,assigned_and_evaluated +10888,83032,15.661706,0.8828125,SH3 Domains,gene3d,83032,SH3 Domains,0.8828125,34,gene3d,2.30.30.40,gene3d:gene3d:2.30.30.40,6.0,2257.0,0.9997038353324449,0.8734126984126983,0.002658396101019052,1.0,328.5487433862433,10.0,17.0,172.7644161112721,8.4797651257297e-21,SH3-like beta-barrel ligand-binding motif,True,assigned_and_evaluated +10889,37894,16.909931,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.82958984,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,7.0,709.7738095238095,2.2341786607428882e-20,SDR catalytic helical core,True,assigned_too_few_test_positives +10890,88058,76.541985,0.8486328,Signal,keyword,88058,Signal,0.8486328,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8535263404543368,0.5599835628993648,0.09127159946832078,0.7378640776699029,6.1353538906012925,18.0,18.0,7.204954682779456,8.53289450276625e-16,Post-signal peptide N-terminus,True,assigned_and_evaluated +10891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal CBMs and linkers,False,no_term_above_threshold +10892,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small globular PPI domain,False,no_term_above_threshold +10893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-binding loops at catalytic clefts,False,no_term_above_threshold +10894,87108,18.512321,0.96875,ANK repeat,keyword,88009,Repeat,0.68603516,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9904112297350731,0.39857678888385895,0.003987594151528578,0.5555555555555556,99.95420139009663,10.0,17.0,99.63402406417113,2.1161497182443236e-18,Helical hydrophobic packing signal,True,assigned_and_evaluated +10895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Poly-acidic IDRs with His hotspots,False,no_term_above_threshold +10896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase catalytic YGS motif,False,no_term_above_threshold +10897,85672,23.44334,0.6328125,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.62646484,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5948709290109561,0.16229692018626446,0.01595037660611431,0.19444444444444445,10.175115246122191,11.0,12.0,36.679586129753915,6.526843028237956e-17,P-loop NTPase switch-coupling region,True,assigned_and_evaluated +10898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coil-to-beta edge loops,False,no_term_above_threshold +10899,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leucine-rich repeat solenoid,False,no_term_above_threshold +10900,52940,18.397856,0.9399414,"AMP-binding, conserved site",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9301758,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,14.0,0.0,1.0,Glycosyltransferase donor-binding core,True,assigned_too_few_test_positives +10901,36409,16.054512,0.7216797,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.7216797,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,12.0,0.0,1.0,Pro/Thr-rich cytosolic low-complexity IDRs,True,assigned_too_few_test_positives +10902,64155,21.146385,0.7519531,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.73339844,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,11.0,12.0,254.19806201550387,3.9156673376904766e-26,Noncatalytic RNase H-like scaffold,True,assigned_too_few_test_positives +10903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure boundary capping motifs,False,no_term_above_threshold +10904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ntn hydrolase propeptides,False,no_term_above_threshold +10905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Subtilisin-like catalytic core,False,no_term_above_threshold +10906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular coiled-coil attachment elements,False,no_term_above_threshold +10907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Reader domain N-terminal boundary,False,no_term_above_threshold +10908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T-Pro-rich phospho-regulatory linkers,False,no_term_above_threshold +10909,64026,17.385645,0.9082031,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.8383789,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9428031985784096,0.02569446654341636,0.002658396101019052,,9.66540183141512,0.0,18.0,0.0,1.0,Transmembrane helix entry junctions,True,assigned_and_evaluated +10910,37894,18.955282,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7680664,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,13.0,709.7738095238095,2.0554498274794366e-37,Rossmann-like cofactor-binding loop,True,assigned_too_few_test_positives +10911,45551,20.96939,0.90185547,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.90185547,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,13.0,0.0,1.0,Glycine-anchored H/R micro-loops,True,assigned_too_few_test_positives +10912,50806,22.632536,0.96972656,"Homeobox, conserved site",interpro,87384,DNA-binding,0.65771484,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,HTH recognition-helix base contacts,True,assigned_too_few_test_positives +10913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM-tail module,False,no_term_above_threshold +10914,83267,16.16086,0.9584961,DNA-binding pseudobarrel domain,gene3d,48767,DNA-binding pseudobarrel domain superfamily,0.9580078,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,16.0,0.0,1.0,TLDc beta-rich domain,True,assigned_too_few_test_positives +10915,49061,30.981552,0.9814453,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9814453,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9944241492020766,0.49058291004588245,0.012405848471422242,1.0,39.54448671334131,15.0,18.0,82.39496959646213,2.6044875936204233e-27,Beta-propeller loop-strand turns,True,assigned_and_evaluated +10916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphorylation-regulated disordered SLiM hubs,False,no_term_above_threshold +10917,87489,16.906103,0.80810547,GPI-anchor,keyword,87522,Glycoprotein,0.61865234,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8327619047619048,0.05700975327432199,0.0031014621178555605,,18.38157330573496,0.0,20.0,0.0,1.0,N-terminal soluble pre-TM region,True,assigned_and_evaluated +10918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic hydrophobic helical surfaces,False,no_term_above_threshold +10919,85672,31.426752,0.9038086,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8779297,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9415240882485367,0.1688122350710764,0.01595037660611431,,10.583589293206096,4.0,17.0,9.41508093170154,0.0012587916594561115,Aliphatic beta-strand core segments,True,assigned_and_evaluated +10920,36668,15.599353,0.9135742,AMP-dependent synthetase/ligase domain,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6982422,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,15.0,0.0,1.0,Adenylate-binding pocket motif,True,assigned_too_few_test_positives +10921,45551,19.934128,0.79345703,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.79345703,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,13.0,0.0,1.0,Catalytic TM helix-loop caps,True,assigned_too_few_test_positives +10922,25014,17.714058,0.78808594,endoplasmic reticulum membrane,go_cc,88159,Transmembrane,0.62158203,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.7134049119197633,0.0733554033957486,0.015507310589277802,,4.73037558469156,5.0,20.0,9.212144622991348,0.0002924656912312886,Terminal single-pass membrane anchors,True,assigned_and_evaluated +10923,37430,21.692398,0.9584961,"Signal transduction response regulator, receiver domain",interpro,6678,phosphorelay signal transduction system,0.9140625,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,0.0,6.0,0.0,1.0,ABC NBD A-loop helix,True,assigned_too_few_test_positives +10924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KS3 glycine-rich loop,False,no_term_above_threshold +10925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase cores and helical hinges,False,no_term_above_threshold +10926,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coupling transmembrane helix motif,False,no_term_above_threshold +10927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil scaffolds,False,no_term_above_threshold +10928,36091,28.934055,0.9794922,GNAT domain,interpro,85712,3.40.630.30,0.94433594,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,19.0,0.0,1.0,Histidine kinase CA-domain motifs,True,assigned_too_few_test_positives +10929,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-rich low-complexity linkers,False,no_term_above_threshold +10930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho rich acidic disordered regions,False,no_term_above_threshold +10931,87991,16.343956,0.83984375,Pyrrolidone carboxylic acid,keyword,87991,Pyrrolidone carboxylic acid,0.83984375,223,keywords,Pyrrolidone carboxylic acid,keyword:keywords:Pyrrolidone carboxylic acid,11.0,2257.0,0.8584554359264956,0.29449899656626655,0.004873726185201595,0.36363636363636365,60.425839568187605,0.0,19.0,0.0,1.0,Polar/proline-rich IDR tails,True,assigned_and_evaluated +10932,38317,19.791138,0.96972656,Pentatricopeptide repeat,interpro,88009,Repeat,0.7006836,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9351111111111111,0.036920309183841295,0.0031014621178555605,,11.904162546847115,0.0,16.0,0.0,1.0,Globular hydrophobic core packing,True,assigned_and_evaluated +10933,87601,15.798726,0.6201172,Hydrolase,keyword,87601,Hydrolase,0.6201172,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6146856964592107,0.08590131928214897,0.05316792202038104,,1.615660646831752,3.0,17.0,1.9736171339666988,0.30069602547205365,Beta-alpha loop active sites,True,assigned_and_evaluated +10934,87276,43.90553,0.70458984,Cell membrane,keyword,88161,Transmembrane helix,0.6796875,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7241174881729314,0.3884279471426427,0.11120957022596367,0.4900398406374502,3.4927564808802574,6.0,16.0,3.0770540875309664,0.015047065051605038,Aromatic-basic transmembrane helix,True,assigned_and_evaluated +10935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extracellular ectodomains,False,no_term_above_threshold +10936,37894,17.20516,0.7651367,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7651367,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,12.0,532.3303571428571,8.985243640725844e-24,Conserved anion-binding hotspots,True,assigned_too_few_test_positives +10937,85682,16.10737,0.81396484,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.81396484,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.940600358422939,0.13586410111334424,0.011076650420912717,0.08,12.265811048512717,0.0,12.0,0.0,1.0,Buried hydrophobic pocket lining,True,assigned_and_evaluated +10938,46932,42.392433,0.9819336,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.9819336,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.99942145082332,0.8803646353646354,0.004430660168365086,1.0,198.69829820179822,19.0,20.0,102.79482758620689,2.0560352118215612e-37,C2H2 finger terminal histidine,True,assigned_and_evaluated +10939,36449,19.200129,0.97802734,EamA domain,interpro,50338,"GPCR, rhodopsin-like, 7TM",0.88378906,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,16.0,0.0,1.0,Aromatic TM glycolipid cavity,True,assigned_too_few_test_positives +10940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tails/linkers,False,no_term_above_threshold +10941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic alpha-helical interaction motifs,False,no_term_above_threshold +10942,36535,16.113934,0.9716797,Protein kinase domain,interpro,87855,Nucleotide-binding,0.71435547,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.985491766800178,0.8929850746268656,0.004430660168365086,0.9,201.54673134328357,15.0,15.0,89.79066265060241,1.585928718533337e-29,Protein kinase catalytic motifs,True,assigned_and_evaluated +10943,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site acidic–aromatic loops,False,no_term_above_threshold +10944,85664,24.417944,0.9399414,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9399414,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,2.0,14.0,47.31825396825397,0.0014204419154572835,GT-A/GT-B catalytic core,True,assigned_too_few_test_positives +10945,36409,18.323212,0.99072266,"Zinc finger, CCCH-type",interpro,29166,zinc ion binding,0.66552734,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,15.0,0.0,1.0,Zinc-knuckle RNA-binding motif,True,assigned_too_few_test_positives +10946,85762,27.42856,0.96728516,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.95654297,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,15.0,16.0,192.74030172413794,1.0564145132955471e-33,Flavoprotein Rossmann glycine loop,True,assigned_too_few_test_positives +10947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Condensing-enzyme gating segment,False,no_term_above_threshold +10948,58239,21.777315,0.64501953,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.64501953,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.679488046910239,0.1842522272352303,0.017722640673460344,0.225,10.39643192174787,13.0,18.0,25.892730674149796,1.0733544545911611e-16,Extended charged low-complexity regions,True,assigned_and_evaluated +10949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LβH acyltransferase/γ-CA fold,False,no_term_above_threshold +10950,25079,17.500048,0.61816406,plasma membrane,go_cc,25079,plasma membrane,0.61816406,2373,go,GO:0005886,go_cc:go:GO:0005886,276.0,2257.0,0.8147153392006672,0.41114052792708244,0.12228622064687639,0.5688405797101449,3.362116563519656,2.0,17.0,0.7440580560218147,1.0,Short surface-exposed interface/targeting segments,True,assigned_and_evaluated +10951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AEP/PrimPol catalytic core signature,False,no_term_above_threshold +10952,37446,15.988039,0.72802734,F-box domain,interpro,63831,F-box-like domain superfamily,0.7260742,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.7072380952380952,0.1660579783530603,0.0031014621178555605,0.42857142857142855,53.54183673469387,4.0,19.0,49.03042763157894,2.343367731214874e-06,Broad structured core activation,True,assigned_and_evaluated +10953,50338,15.750186,0.8232422,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8232422,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Proline-rich beta-turn junctions,True,assigned_too_few_test_positives +10954,81858,16.844934,0.74609375,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.74609375,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Histidine kinase juxta-His helix,True,assigned_too_few_test_positives +10955,38873,20.02729,0.94873047,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.86083984,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9924511545293073,0.2067929292929293,0.002215330084182543,,93.3463282828283,3.0,19.0,27.051270417422867,0.0003226356642609048,P-loop ATPase switch (Walker-B/Sensor),True,assigned_and_evaluated +10956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix cores,False,no_term_above_threshold +10957,46932,20.557554,0.95654297,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.95654297,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9622162883845126,0.17612568280805338,0.004430660168365086,0.2,39.75156660977765,3.0,17.0,19.095014412298493,0.000861708451175254,Ser/Thr helix N-cap recognition,True,assigned_and_evaluated +10958,87857,19.446045,0.6040039,Nucleus,keyword,87857,Nucleus,0.6040039,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6313900172947755,0.16173451767070268,0.06247230837394772,0.06382978723404255,2.5888993360480566,14.0,19.0,4.464559264013692,1.1029384919944783e-07,Acidic N-terminal activation IDRs,True,assigned_and_evaluated +10959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr kinase catalytic subregion detector,False,no_term_above_threshold +10960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse beta-strand core signal,False,no_term_above_threshold +10961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass TM helix scaffold,False,no_term_above_threshold +10962,87566,17.431818,0.6621094,Homeobox,keyword,87566,Homeobox,0.6621094,80,keywords,Homeobox,keyword:keywords:Homeobox,,,,,,,,1.0,20.0,10.003523489932887,0.15448870881870588,Homeodomain ILV helical patch,True,assigned_too_few_test_positives +10963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and termini,False,no_term_above_threshold +10964,64148,22.260315,0.6723633,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6723633,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6820469404073185,0.2988840436640264,0.008418254319893664,0.3684210526315789,35.504278239458294,11.0,19.0,51.518538884524745,5.637256102475075e-17,IclR effector pocket region,True,assigned_and_evaluated +10965,38873,20.08069,0.76904297,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63183594,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7963587921847247,0.1170766082241492,0.002215330084182543,,52.84838095238095,9.0,13.0,118.60941644562334,1.2241497189578972e-17,Clamp-loader-biased AAA+ activation,True,assigned_and_evaluated +10966,36668,19.17335,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.98535156,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,12.0,12.0,532.3303571428571,4.767704854105715e-33,AMP-binding ANL loop motifs,True,assigned_too_few_test_positives +10967,58239,17.024355,0.6196289,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6196289,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6533998646820026,0.15558599725312997,0.017722640673460344,0.1,8.77893989500786,13.0,13.0,35.851473241130485,1.5607041751034244e-20,ASCE P-loop ATPase core,True,assigned_and_evaluated +10968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycosidase/ectoenzyme domains,False,no_term_above_threshold +10969,63831,18.432344,0.91064453,F-box-like domain superfamily,interpro,87326,Coiled coil,0.71777344,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9338071968014215,0.02162399711132286,0.002658396101019052,,8.134226913375949,0.0,12.0,0.0,1.0,Leucine zipper coiled-coil,True,assigned_and_evaluated +10970,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic peptidoglycan-binding tethers,False,no_term_above_threshold +10971,64620,16.275995,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9609375,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,17.0,324.0271739130435,1.225281491287518e-42,CA domain terminal β-strand,True,assigned_too_few_test_positives +10972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich coiled-coil scaffolds,False,no_term_above_threshold +10973,48767,16.078371,0.99316406,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99316406,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,18.0,0.0,1.0,PDZ beta-sandwich GLGF loop,True,assigned_too_few_test_positives +10974,37071,16.545954,0.85302734,Homeodomain,interpro,88148,Transcription,0.6118164,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,11.0,0.0,1.0,Plant-biased TF DBD–IDR junction,True,assigned_too_few_test_positives +10975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent structural elements,False,no_term_above_threshold +10976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil stalk helices,False,no_term_above_threshold +10977,88154,16.423504,0.81396484,Transit peptide,keyword,88058,Signal,0.7753906,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.7873096730855351,0.02465811942063989,0.010633584404076208,,2.318890647182676,5.0,19.0,7.683514614155368,0.0006516564944058285,Early N-terminal disordered patch,True,assigned_and_evaluated +10978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WYL WCX C-terminal extension,False,no_term_above_threshold +10979,81349,15.876247,0.98291016,1.10.287.1490,gene3d,87326,Coiled coil,0.6845703,31,gene3d,1.10.287.1490,gene3d:gene3d:1.10.287.1490,,,,,,,,7.0,17.0,147.8905031892275,4.966368586501301e-14,Coiled-coil heptad stripe,True,assigned_too_few_test_positives +10980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regulatory interaction segments,False,no_term_above_threshold +10981,64148,28.720264,0.9790039,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.91796875,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9862776915479046,0.6210100318272063,0.008418254319893664,0.631578947368421,73.76945483336867,16.0,19.0,74.93605655930871,1.7622190057414677e-28,Beta-strand wing DNA contacts,True,assigned_and_evaluated +10982,47529,18.62317,0.6772461,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6772461,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7465696117804552,0.3220770372922012,0.007089056269384138,0.25,45.43299207303114,3.0,17.0,13.646372167544062,0.0022382898514324294,Extracellular N-terminal accessory regions,True,assigned_and_evaluated +10983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal docking interface,False,no_term_above_threshold +10984,45290,31.599373,0.9746094,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9746094,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9573392293980529,0.8565224704833376,0.0057598582188746125,0.8461538461538461,148.70547814468407,17.0,17.0,73.42487684729065,6.829036441178294e-32,Kinase ATP-binding P-loop,True,assigned_and_evaluated +10985,85672,16.15294,0.72216797,P-loop containing nucleotide triphosphate hydrolases,gene3d,87601,Hydrolase,0.6508789,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7835497023362848,0.0666309556324287,0.01595037660611431,,4.177390746177544,0.0,16.0,0.0,1.0,His-centered glycine-rich loop,True,assigned_and_evaluated +10986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-metal enzyme entry motif,False,no_term_above_threshold +10987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carboxylate-activating beta-alpha motif,False,no_term_above_threshold +10988,52236,20.526428,0.98779297,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9838867,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,13.0,17.0,170.75853712271422,1.692590356210517e-27,TPR linker and terminal helices,True,assigned_too_few_test_positives +10989,47529,15.626799,0.71240234,Immunoglobulin-like fold,interpro,87522,Glycoprotein,0.61572266,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6619812583668004,0.06135523572598271,0.007089056269384138,,8.654922939596437,0.0,20.0,0.0,1.0,Luminal/extracellular membrane ectodomains,True,assigned_and_evaluated +10990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity disordered tails,False,no_term_above_threshold +10991,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemoreceptor coiled-coil stalks,False,no_term_above_threshold +10992,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane termini gating motifs,False,no_term_above_threshold +10993,81858,17.719742,0.78466797,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.60839844,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Extracytoplasmic interfacial aromatic segment,True,assigned_too_few_test_positives +10994,88263,16.21307,0.62646484,Zinc-finger,keyword,88263,Zinc-finger,0.62646484,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.5715404948768259,0.16547593596773924,0.014621178555604785,0.15151515151515152,11.317551135732954,18.0,19.0,24.686648877438348,1.6629861725893146e-24,Zinc-finger-like interaction modules,True,assigned_and_evaluated +10995,47128,16.611233,0.96777344,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47529,Immunoglobulin-like fold,0.88378906,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,1.0,16.0,16.061691810344826,0.09912541672979941,β-strand–rich extracellular interfaces,True,assigned_too_few_test_positives +10996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel gating loops,False,no_term_above_threshold +10997,12385,15.92684,0.95996094,mitochondrial translation,go_bp,87785,Mitochondrion,0.6933594,35,go,GO:0032543,go_bp:go:GO:0032543,,,,,,,,8.0,20.0,92.07876447876447,3.153381470263097e-14,Mature organellar soluble regions,True,assigned_too_few_test_positives +10998,31094,16.23267,0.9243164,phosphopantetheine binding,go_mf,85682,NAD(P)-binding Rossmann-like Domain,0.78222656,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.944570538495772,0.27526500333877385,0.004430660168365086,,62.12731125356126,0.0,16.0,0.0,1.0,N-terminal Rossmann dinucleotide loop,True,assigned_and_evaluated +10999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PQQ cytochrome c interdomain linker,False,no_term_above_threshold +11000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix boundaries and kinks,False,no_term_above_threshold +11001,38317,23.875853,0.98876953,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.98876953,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9995555555555555,0.8631519274376416,0.0031014621178555605,1.0,278.3048428895367,9.0,19.0,182.20339558573852,9.718840480628349e-19,Post-transit PPR helical solenoid,True,assigned_and_evaluated +11002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent outer membrane barrels,False,no_term_above_threshold +11003,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal glycan-binding edge regions,False,no_term_above_threshold +11004,37020,18.951454,0.9555664,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.8310547,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,18.0,0.0,1.0,Active-site lids and loops,True,assigned_too_few_test_positives +11005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting and processing signals,False,no_term_above_threshold +11006,47529,20.010141,0.9404297,Immunoglobulin-like fold,interpro,87413,Disulfide bond,0.6411133,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9732820169567157,0.49202167766363564,0.007089056269384138,0.4375,69.4058079054266,13.0,17.0,59.13427939269093,1.570587248850288e-21,FN3/Ig beta-strand surfaces,True,assigned_and_evaluated +11007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor helix,False,no_term_above_threshold +11008,49045,18.0563,0.99658203,Kelch-type beta propeller,interpro,49045,Kelch-type beta propeller,0.99658203,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,1.0,18.0,30.11161616161616,0.05429308621243027,W-rich beta-repeat edge motifs,True,assigned_too_few_test_positives +11009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix-turn oligomerization motif,False,no_term_above_threshold +11010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix boundary/capping signal,False,no_term_above_threshold +11011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular pocket-adjacent segments,False,no_term_above_threshold +11012,36914,20.57168,0.9970703,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,2.0,15.0,98.14156378600823,0.0003421755722056874,Post-DxD donor-binding helix-loop-beta,True,assigned_too_few_test_positives +11013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core binding face segment,False,no_term_above_threshold +11014,85364,15.7565155,0.68896484,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.68896484,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,16.0,19.0,253.57150451887293,6.842393173280208e-37,C-terminal extracytoplasmic polar segments,True,assigned_too_few_test_positives +11015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C/PPM beta-alpha active-site motif,False,no_term_above_threshold +11016,47529,28.496992,0.97998047,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.97998047,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9985776439089692,0.7856597276634042,0.007089056269384138,1.0,110.82712533351895,15.0,18.0,64.4412019022914,1.0108141398209011e-25,Extracellular beta-strand cores,True,assigned_and_evaluated +11017,85672,24.966385,0.6142578,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61376953,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5937890839961979,0.12179953177220937,0.01595037660611431,0.16666666666666666,7.636153978052127,12.0,12.0,40.01409395973155,1.4584552891973136e-19,P-loop inter-Walker catalytic segment,True,assigned_and_evaluated +11018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase RNA-binding signature,False,no_term_above_threshold +11019,52270,16.527672,0.9892578,"WD40 repeat, conserved site",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.8486328,43,ip,IPR019775,interpro:ip:IPR019775,,,,,,,,0.0,18.0,0.0,1.0,GT-A DxD metal-binding loop,True,assigned_too_few_test_positives +11020,59224,32.866035,0.9897461,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9897461,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,20.0,20.0,137.37557603686636,1.3818410501239142e-42,AB hydrolase oxyanion hole motif,True,assigned_and_evaluated +11021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-residue peaks in helices/coils,False,no_term_above_threshold +11022,64148,15.737656,0.7866211,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7866211,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.7590188608249847,0.024986817233490423,0.008418254319893664,,2.9681708682098886,0.0,13.0,0.0,1.0,Conserved loop motif activations,True,assigned_and_evaluated +11023,88058,20.355322,0.6225586,Signal,keyword,88058,Signal,0.6225586,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.651283058702125,0.11629435239893585,0.09127159946832078,,1.2741570551669816,4.0,20.0,1.4409909365558913,0.4670478563492871,Low-complexity disordered regions,True,assigned_and_evaluated +11024,37446,32.5533,0.99609375,F-box domain,interpro,63831,F-box-like domain superfamily,0.99560547,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9993015873015872,0.7596165739022882,0.0031014621178555605,1.0,244.92208675678063,17.0,20.0,197.96035156249997,2.368875867757361e-37,N-terminal CRL adaptor module,True,assigned_and_evaluated +11025,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered basic N-terminal tails,False,no_term_above_threshold +11026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved functional domain cores,False,no_term_above_threshold +11027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory scaffolds and interface residues,False,no_term_above_threshold +11028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical core residues,False,no_term_above_threshold +11029,88162,17.353804,0.6323242,Transport,keyword,88162,Transport,0.6323242,1387,keywords,Transport,keyword:keywords:Transport,141.0,2257.0,0.6770049873305714,0.11268693336409717,0.06247230837394772,0.0070921985815602835,1.80379013193452,3.0,18.0,1.892009393247017,0.3274567248355397,Juxtamembrane helix-capping interface motifs,True,assigned_and_evaluated +11030,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipoyl/biotin carrier domains,False,no_term_above_threshold +11031,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic cofactor-binding helix caps,False,no_term_above_threshold +11032,64016,21.665854,0.8808594,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.8754883,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9058095238095238,0.07234689432535435,0.0031014621178555605,,23.326705784617822,0.0,18.0,0.0,1.0,Helix-loop-beta junction motif,True,assigned_and_evaluated +11033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic transmembrane core segments,False,no_term_above_threshold +11034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich C-terminal IDRs,False,no_term_above_threshold +11035,45804,16.876888,0.8203125,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.7988281,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,16.0,0.0,1.0,Loop-to-TM helix transition,True,assigned_too_few_test_positives +11036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Boundary linker and hinge elements,False,no_term_above_threshold +11037,59224,15.709505,0.8984375,Alpha/Beta hydrolase fold,interpro,88153,Transferase,0.67041016,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9363809523809523,0.08395415391859384,0.0031014621178555605,,27.069217913466616,2.0,15.0,18.316743471582182,0.008969944093529176,N-terminal domain-start scaffold,True,assigned_and_evaluated +11038,4066,16.790342,0.7529297,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.7529297,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.49489342806394315,0.002215330084182543,0.002215330084182543,,1.0,0.0,20.0,0.0,1.0,Solvent exposed interface hotspots,True,assigned_and_evaluated +11039,25167,16.844006,0.6123047,cell outer membrane,go_cc,25167,cell outer membrane,0.6123047,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7047141796585004,0.22203421065586726,0.005316792202038104,0.16666666666666666,41.76093445419103,6.0,16.0,51.162185354691076,2.3138184498252656e-09,Outer-membrane beta-barrel porins,True,assigned_and_evaluated +11040,46079,43.55249,0.9760742,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9760742,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.8778966131907308,0.3027965090200829,0.0057598582188746125,0.07692307692307693,52.57013237371747,15.0,18.0,77.63151041666667,6.318363781606449e-27,TPR/HEAT repeat-start recognition,True,assigned_and_evaluated +11041,55053,21.51779,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,11.0,11.0,552.0462962962963,1.580946100244615e-30,Acyl-thioester catalytic strand,True,assigned_too_few_test_positives +11042,52236,20.114477,0.9707031,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9663086,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,7.0,17.0,91.94690460453843,1.379150761454391e-12,Helix-start N-capping motif,True,assigned_too_few_test_positives +11043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase H-like phosphate-binding loops,False,no_term_above_threshold +11044,25169,18.039495,0.8955078,pilus,go_cc,25169,pilus,0.8955078,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9784635879218473,0.05453034547011271,0.002215330084182543,,24.614997945208877,0.0,16.0,0.0,1.0,Short acidic loop/turn motif,True,assigned_and_evaluated +11045,64085,17.082678,0.8300781,WD40-repeat-containing domain superfamily,interpro,64085,WD40-repeat-containing domain superfamily,0.8300781,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9683794783054542,0.30850806978056594,0.012405848471422242,,24.867954053383475,3.0,19.0,18.56773590781688,0.000949257543208473,Eukaryotic assembly scaffolds,True,assigned_and_evaluated +11046,52940,16.209297,0.95654297,"AMP-binding, conserved site",interpro,36668,AMP-dependent synthetase/ligase domain,0.89453125,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,12.0,0.0,1.0,Small-residue beta-helix coil connectors,True,assigned_too_few_test_positives +11047,6543,18.889088,0.75341797,NADH:ubiquinone reductase (H+-translocating),ec,6543,NADH:ubiquinone reductase (H+-translocating),0.75341797,41,ec,7.1.1.2,ec:ec:7.1.1.2,,,,,,,,0.0,5.0,0.0,1.0,Transmembrane helix–loop interfaces,True,assigned_too_few_test_positives +11048,59224,17.087086,0.9033203,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9033203,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9780634920634921,0.07430275309200852,0.0031014621178555605,,23.957330532666177,0.0,16.0,0.0,1.0,Pocket-lining beta-strand termini,True,assigned_and_evaluated +11049,64585,23.681194,0.9394531,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.91064453,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,16.0,0.0,1.0,Surface beta-strand loop connectors,True,assigned_too_few_test_positives +11050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich low-complexity regions,False,no_term_above_threshold +11051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundaries and kinks,False,no_term_above_threshold +11052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBS Bateman domain boundaries,False,no_term_above_threshold +11053,45290,32.679054,0.97216797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97216797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9605614973262033,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,15.0,16.0,68.83582204433498,4.67155893575084e-27,Kinase pre-catalytic loop helix,True,assigned_and_evaluated +11054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GspF/PilC C-terminal cytosolic domain,False,no_term_above_threshold +11055,47531,16.891373,0.75097656,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.75097656,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,11.0,16.0,173.68405720338984,3.602748518584917e-23,Active-site lid loops,True,assigned_too_few_test_positives +11056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal soluble regulatory domains,False,no_term_above_threshold +11057,36115,16.90065,0.7651367,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.76220703,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,14.0,0.0,1.0,Helix boundary caps and kinks,True,assigned_too_few_test_positives +11058,28025,18.152792,0.82470703,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.69384766,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.995409447652895,0.2534642401021711,0.002658396101019052,,95.34479831843336,0.0,12.0,0.0,1.0,Post–Walker A Q-loop linker,True,assigned_and_evaluated +11059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core beta-loop scaffold,False,no_term_above_threshold +11060,31094,17.542088,0.9921875,phosphopantetheine binding,go_mf,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.97021484,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9968847352024922,0.5325575201036231,0.004430660168365086,0.2,120.19823228738774,11.0,13.0,600.5778388278388,6.412544739037915e-30,Flexible thioester gating loops,True,assigned_and_evaluated +11061,87149,17.096203,0.7294922,Amphibian defense peptide,keyword,87158,Antibiotic,0.70703125,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6558434275459848,0.027713563358335642,0.012405848471422242,,2.233911160705841,0.0,19.0,0.0,1.0,Helical MoRF/SLiM motifs,True,assigned_and_evaluated +11062,82029,28.502806,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9902344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS helix-packing hotspots,True,assigned_too_few_test_positives +11063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic CAZyme glycan-binding surfaces,False,no_term_above_threshold +11064,45714,16.815838,0.9057617,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8666992,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,18.0,0.0,1.0,DHp helix H+7 site,True,assigned_too_few_test_positives +11065,82107,15.867151,0.93115234,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.9086914,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,16.0,0.0,1.0,Conserved tryptophan domain anchors,True,assigned_too_few_test_positives +11066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic/luminal TM1–TM2 sensor domain,False,no_term_above_threshold +11067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved turn/edge residues,False,no_term_above_threshold +11068,64058,17.960999,0.9008789,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7866211,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9757340296796382,0.2138844147052602,0.006202924235711121,,34.48122314212659,0.0,17.0,0.0,1.0,Active-site helical residues,True,assigned_and_evaluated +11069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP enzyme C-terminal SWW motif,False,no_term_above_threshold +11070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-polar loop micro-motif,False,no_term_above_threshold +11071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA transposase catalytic cores,False,no_term_above_threshold +11072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal functional module,False,no_term_above_threshold +11073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site rim beta-alpha transitions,False,no_term_above_threshold +11074,36977,16.661322,0.9560547,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8413086,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,15.0,0.0,1.0,ABC permease late TM helix,True,assigned_too_few_test_positives +11075,87149,20.084173,0.6870117,Amphibian defense peptide,keyword,88058,Signal,0.6381836,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6509325129782734,0.021970143572082986,0.012405848471422242,,1.770950501506832,0.0,19.0,0.0,1.0,Solvent exposed polar helices,True,assigned_and_evaluated +11076,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavoprotein FAD-binding scaffold,False,no_term_above_threshold +11077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular juxtadomain stalks,False,no_term_above_threshold +11078,81685,26.296818,0.9711914,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9658203,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9576466221232368,0.9171097326835032,0.005316792202038104,0.9166666666666666,172.49305555555554,15.0,15.0,85.66235632183908,3.186653641792077e-29,Kinase alphaC helix activation,True,assigned_and_evaluated +11079,47529,22.684868,0.84716797,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.84716797,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9495760821062026,0.2166132705352775,0.007089056269384138,,30.556009474882586,5.0,16.0,24.165450713359274,2.652498278688765e-06,Polar windows in beta-rich proteins,True,assigned_and_evaluated +11080,36010,20.098137,0.9921875,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9848633,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,8.0,17.0,239.80291603821018,1.0187647380592857e-17,AB hydrolase H-G-x-D motif,True,assigned_too_few_test_positives +11081,85712,29.241556,0.99121094,3.40.630.30,gene3d,85712,3.40.630.30,0.99121094,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,18.0,19.0,268.96691729323305,8.290426350539573e-43,Helix–loop–β connector motif,True,assigned_too_few_test_positives +11082,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His-rich pseudouridine synthase motif,False,no_term_above_threshold +11083,37894,20.066755,0.84033203,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.84033203,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,13.0,0.0,1.0,Active-site-adjacent helical segment,True,assigned_too_few_test_positives +11084,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T/P-rich regulatory IDRs,False,no_term_above_threshold +11085,47531,16.044142,0.7480469,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.7480469,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,0.0,15.0,0.0,1.0,Active-site proximal segment,True,assigned_too_few_test_positives +11086,38317,29.328033,0.99609375,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.99609375,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9973333333333333,0.37684240362811794,0.0031014621178555605,0.7142857142857143,121.50475785552317,0.0,17.0,0.0,1.0,Small-residue stabilizing hotspots,True,assigned_and_evaluated +11087,48767,21.646217,0.97265625,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.97265625,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,17.0,0.0,1.0,Nucleic acid/mark recognition cores,True,assigned_too_few_test_positives +11088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly/attachment segment,False,no_term_above_threshold +11089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding loop and helix,False,no_term_above_threshold +11090,36104,21.933723,0.9711914,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9711914,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Molybdopterin VRNHG motif,True,assigned_too_few_test_positives +11091,88009,22.522078,0.6489258,Repeat,keyword,88009,Repeat,0.6489258,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.761442030927715,0.2164145004193103,0.07266282676118742,0.03048780487804878,2.9783385819901422,7.0,15.0,4.137268897149938,0.001155126861283036,Coiled coil hydrophobic hotspots,True,assigned_and_evaluated +11092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure boundary residues,False,no_term_above_threshold +11093,50338,19.513945,0.9238281,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.90771484,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,GPCR TM6 transmembrane helices,True,assigned_too_few_test_positives +11094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix caps and kinks,False,no_term_above_threshold +11095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural landmark residue detector,False,no_term_above_threshold +11096,50338,16.826258,0.8564453,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8564453,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,Phosphohistidine helix N-cap,True,assigned_too_few_test_positives +11097,81858,18.11038,0.94921875,Rhodopsin 7-helix transmembrane proteins,gene3d,88006,Receptor,0.73779297,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,16.0,16.0,261.4956140350877,9.006051383641506e-39,Class A GPCR 7TM core,True,assigned_too_few_test_positives +11098,85672,40.608376,0.94189453,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.94091797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.886981589874431,0.5011718911714652,0.01595037660611431,0.5555555555555556,31.420693288166586,16.0,17.0,37.66032372680616,1.0625257265577e-24,AAA+ Sensor-1 loop hinge,True,assigned_and_evaluated +11099,88161,64.22466,0.76416016,Transmembrane helix,keyword,88161,Transmembrane helix,0.76416016,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8086493848399542,0.6405579617518089,0.1847585290208241,0.7122302158273381,3.4670007666039155,14.0,14.0,5.4274920345926265,1.0920821671226735e-10,Juxtamembrane loop-helix caps,True,assigned_and_evaluated +11100,87162,15.762816,0.67529297,Antimicrobial,keyword,24917,nucleus,0.6303711,669,keywords,Antimicrobial,keyword:keywords:Antimicrobial,56.0,2257.0,0.6861653793730123,0.03858037174855926,0.024811696942844484,,1.5549267685088972,0.0,15.0,0.0,1.0,Amphipathic interface helices,True,assigned_and_evaluated +11101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic short catalytic-core segments,False,no_term_above_threshold +11102,52236,17.046736,0.99121094,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.93310547,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,20.0,189.80468164794004,4.837972073931822e-37,TPR/SEL1 alpha-solenoid repeats,True,assigned_too_few_test_positives +11103,85672,24.668518,0.70947266,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.703125,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7778465656110862,0.29674896547379015,0.01595037660611431,0.3055555555555556,18.6045115298429,13.0,13.0,40.01409395973155,3.774017721320684e-21,Phosphate-binding β–loop–α motif,True,assigned_and_evaluated +11104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered S/T-rich surface linkers,False,no_term_above_threshold +11105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane transporter helix signature,False,no_term_above_threshold +11106,37312,16.676016,0.98291016,"DNA-binding HTH domain, TetR-type",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8833008,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,13.0,0.0,1.0,Post-Walker A hydrophobic cap,True,assigned_too_few_test_positives +11107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RND periplasmic beta-strand motif,False,no_term_above_threshold +11108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Subtilisin-like catalytic connector loops,False,no_term_above_threshold +11109,37071,19.496826,0.8339844,Homeodomain,interpro,37071,Homeodomain,0.8339844,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,17.0,0.0,1.0,Amphipathic docking helices,True,assigned_too_few_test_positives +11110,25169,19.96974,0.7607422,pilus,go_cc,87465,Fimbrium,0.7368164,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9949378330373001,0.22182611701667962,0.002215330084182543,,100.13230922132918,0.0,17.0,0.0,1.0,Extracellular cadherin repeat motifs,True,assigned_and_evaluated +11111,88277,20.535128,0.8720703,rRNA-binding,keyword,88022,Ribosomal protein,0.8305664,96,keywords,rRNA-binding,keyword:keywords:rRNA-binding,19.0,2257.0,0.9400075255162035,0.4867301767330216,0.008418254319893664,0.7894736842105263,57.81842152033841,13.0,16.0,148.59528374233128,5.515477835120171e-27,Polyelectrolyte terminal IDRs,True,assigned_and_evaluated +11112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain/tail marker,False,no_term_above_threshold +11113,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic pockets and helical scaffolds,False,no_term_above_threshold +11114,47529,20.730703,0.7524414,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.7524414,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7041359883980365,0.10739702878827719,0.007089056269384138,0.125,15.14969337344635,1.0,18.0,4.296080126819426,0.3291696656304877,Membrane-proximal ectodomain stalk,True,assigned_and_evaluated +11115,36914,15.732753,0.7988281,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.7988281,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,14.0,0.0,1.0,Non-core helicase accessory regions,True,assigned_too_few_test_positives +11116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich receptor-binding head,False,no_term_above_threshold +11117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structured-domain activation peak,False,no_term_above_threshold +11118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane coupling segments,False,no_term_above_threshold +11119,36354,20.188478,0.9926758,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.97509766,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,17.0,0.0,1.0,Catalytic strand-loop caps,True,assigned_too_few_test_positives +11120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domain core detector,False,no_term_above_threshold +11121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and polymerase core,False,no_term_above_threshold +11122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tryptophan-centric aromatic hotspots,False,no_term_above_threshold +11123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-associated active-site loops,False,no_term_above_threshold +11124,85682,27.602236,0.7158203,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7158203,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.5773745519713261,0.11930438635356669,0.011076650420912717,0.12,10.7708,16.0,16.0,102.26586620926243,2.472580145272991e-32,Rossmann oxidoreductase C-terminal catalytic lobe,True,assigned_and_evaluated +11125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β–α junction binding loops,False,no_term_above_threshold +11126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Icosahedral capsid jelly-roll core,False,no_term_above_threshold +11127,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM N-cap interface segments,False,no_term_above_threshold +11128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid binding processivity interfaces,False,no_term_above_threshold +11129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic helix-capping linkers,False,no_term_above_threshold +11130,47529,28.18487,0.98876953,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.98876953,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9971552878179384,0.7613720657067431,0.007089056269384138,0.75,107.40104701875745,16.0,16.0,77.32944228274968,2.0259079421166962e-30,Ig/FN3 surface loops,True,assigned_and_evaluated +11131,85672,16.2897,0.7182617,P-loop containing nucleotide triphosphate hydrolases,gene3d,88153,Transferase,0.64453125,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7741695432487867,0.12088777508145347,0.01595037660611431,0.027777777777777776,7.578991898856681,0.0,15.0,0.0,1.0,Acidic helical metal-phosphate motif,True,assigned_and_evaluated +11132,84152,16.987831,0.7963867,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.7963867,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,14.0,0.0,1.0,GH groove-lining segments,True,assigned_too_few_test_positives +11133,59224,19.378626,0.88671875,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.88671875,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9537142857142857,0.04042502953211788,0.0031014621178555605,,13.03418452199858,0.0,15.0,0.0,1.0,Active site beta strand scaffold,True,assigned_and_evaluated +11134,63960,27.258194,0.90771484,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.90771484,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,5.0,0.0,1.0,ABC NBD post-signature helix,True,assigned_too_few_test_positives +11135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered basic RNA-binding arms,False,no_term_above_threshold +11136,36354,22.747185,1.0,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.99316406,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,16.0,16.0,214.4640287769784,2.0510380114444836e-37,Canonical RRM RNA-binding surface,True,assigned_too_few_test_positives +11137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleoporin central coiled-coil domains,False,no_term_above_threshold +11138,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-His β-strand [ILV]P[VL]D motif,False,no_term_above_threshold +11139,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-loop interaction arm,False,no_term_above_threshold +11140,10369,18.241604,0.7475586,DNA integration,go_bp,10369,DNA integration,0.7475586,42,go,GO:0015074,go_bp:go:GO:0015074,,,,,,,,10.0,15.0,364.6544342507645,2.4078983450098327e-24,Integrase HHCC zinc finger,True,assigned_too_few_test_positives +11141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic helix capping loops,False,no_term_above_threshold +11142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exocyst/CATCHR helical rod scaffolds,False,no_term_above_threshold +11143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal interaction domains,False,no_term_above_threshold +11144,36449,17.352507,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,12.0,18.0,709.7738095238095,1.0879119006706701e-32,C-terminal TM helix exits,True,assigned_too_few_test_positives +11145,81858,18.069729,0.8935547,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6567383,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane catalytic channel helices,True,assigned_too_few_test_positives +11146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta-strand core residues,False,no_term_above_threshold +11147,64148,27.559008,0.69433594,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.69433594,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5494332345609332,0.11279528018095748,0.008418254319893664,0.10526315789473684,13.398891966759003,15.0,16.0,83.42490671641791,2.688797228425055e-28,LG-centered LysR wing motif,True,assigned_and_evaluated +11148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase accessory CTDs and tails,False,no_term_above_threshold +11149,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycan-binding rim/lid,False,no_term_above_threshold +11150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory helix-tail,False,no_term_above_threshold +11151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS N-cap coupling helices,False,no_term_above_threshold +11152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary transporter TM helix boundaries,False,no_term_above_threshold +11153,87239,17.209166,0.7988281,CF(1),keyword,85656,alpha/beta hydrolase,0.734375,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.998278945015646,0.6791454791338691,0.008861320336730172,1.0,76.64156732025714,0.0,8.0,0.0,1.0,Extracellular hydrolase cap/linker domain,True,assigned_and_evaluated +11154,87882,15.855209,0.7451172,Palmitate,keyword,88058,Signal,0.6826172,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9762327854286984,0.11848114547763516,0.002658396101019052,,44.568657557170425,1.0,15.0,4.441042830540037,0.32044335030267734,Solvent-exposed acidic flexible loops,True,assigned_and_evaluated +11155,81858,20.575804,0.81103516,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.81103516,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Multi-pass transmembrane alpha-helices,True,assigned_too_few_test_positives +11156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,QG(D/T)xxGDPFW signature motif,False,no_term_above_threshold +11157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helical scaffold,False,no_term_above_threshold +11158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TM anchors and loops,False,no_term_above_threshold +11159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine residue identity detector,False,no_term_above_threshold +11160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded domain core segment,False,no_term_above_threshold +11161,63831,15.783024,0.8798828,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8798828,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7579964460239894,0.005979080308719175,0.002658396101019052,,2.2491307094631963,0.0,10.0,0.0,1.0,Amphipathic helix packing hydrophobes,True,assigned_and_evaluated +11162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structural register anchors,False,no_term_above_threshold +11163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tudor domain boundary activation,False,no_term_above_threshold +11164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interface helix,False,no_term_above_threshold +11165,36668,18.677645,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,18.0,18.0,532.3303571428571,1.2239400872533205e-48,ANL domain helix start hotspots,True,assigned_too_few_test_positives +11166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acyltransferase substrate-gating segment,False,no_term_above_threshold +11167,64381,16.175852,0.9301758,Helix-loop-helix DNA-binding domain superfamily,interpro,87326,Coiled coil,0.71484375,41,ip,IPR036638,interpro:ip:IPR036638,,,,,,,,0.0,20.0,0.0,1.0,Coiled-coil oligomerization helices,True,assigned_too_few_test_positives +11168,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His/Tyr-rich low-complexity regions,False,no_term_above_threshold +11169,81799,16.027409,0.9243164,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7524414,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,8.0,13.0,356.2120985810306,1.9637013912713936e-19,AAA+ pre-P-loop helix,True,assigned_too_few_test_positives +11170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal cytosolic domains,False,no_term_above_threshold +11171,87274,20.365784,0.74316406,Cell inner membrane,keyword,88161,Transmembrane helix,0.6923828,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.9203204429920117,0.6268673050305226,0.0358883473637572,0.691358024691358,17.46715441301098,14.0,17.0,32.112260993344364,8.207229570805238e-20,Juxtamembrane coupling helices,True,assigned_and_evaluated +11172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic accessory segments,False,no_term_above_threshold +11173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly interface cap,False,no_term_above_threshold +11174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic acidic DE-motif detector,False,no_term_above_threshold +11175,36091,20.952646,0.9716797,GNAT domain,interpro,85712,3.40.630.30,0.93603516,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,Hydrophobic beta-strand face,True,assigned_too_few_test_positives +11176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ComE3 central domain signature,False,no_term_above_threshold +11177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical catalytic cores,False,no_term_above_threshold +11178,85672,18.424116,0.6088867,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.60839844,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5802441342738507,0.10513269339843972,0.01595037660611431,0.05555555555555555,6.591235805563291,14.0,14.0,40.01409395973155,9.778128717856954e-23,Helicase/AAA+ P-loop ATPase cores,True,assigned_and_evaluated +11179,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved internal beta/alpha motif,False,no_term_above_threshold +11180,82029,24.749506,1.0,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9946289,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS transmembrane helix-capping hinges,True,assigned_too_few_test_positives +11181,81858,17.27807,0.9609375,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7583008,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane helix signature,True,assigned_too_few_test_positives +11182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble catalytic/binding domains,False,no_term_above_threshold +11183,31094,19.378504,0.96435547,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8203125,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9971740097908323,0.4624465148378191,0.004430660168365086,0.8,104.37417839889578,4.0,17.0,167.00560224089637,1.7293005245140824e-08,Subfamily-specific domain-wide detector,True,assigned_and_evaluated +11184,85672,23.423128,0.8208008,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8144531,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.888551203161739,0.09462039424659972,0.01595037660611431,,5.932173050404877,1.0,14.0,2.858149568552253,0.4670478563492871,PHx(D/E)S loop micro-motif,True,assigned_and_evaluated +11185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured core segment activation,False,no_term_above_threshold +11186,36091,17.140968,0.9863281,GNAT domain,interpro,47529,Immunoglobulin-like fold,0.9550781,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic Ig-like beta-strands,True,assigned_too_few_test_positives +11187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic tails and loops,False,no_term_above_threshold +11188,85649,45.828754,0.9555664,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9536133,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8891148651278657,0.5955195743637784,0.0101905183872397,0.782608695652174,58.43859475387165,14.0,15.0,103.23982683982683,1.0300586552902711e-27,Methyltransferase SAM-binding core,True,assigned_and_evaluated +11189,37430,19.272247,1.0,"Signal transduction response regulator, receiver domain",interpro,85669,3.40.50.2300,0.85253906,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,Two-component phosphorelay cores,True,assigned_too_few_test_positives +11190,87384,16.370512,0.6333008,DNA-binding,keyword,87384,DNA-binding,0.6333008,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.4988719446550772,0.040300480125301845,0.043863535666814356,,0.9187695317455178,2.0,20.0,1.2250051366344772,0.7675321987297693,Disordered S/T-rich interaction segments,True,assigned_and_evaluated +11191,87149,23.609507,0.7529297,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.7529297,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.8595782862270076,0.29239686371598167,0.012405848471422242,0.10714285714285714,23.569275764534666,0.0,17.0,0.0,1.0,Disordered low-complexity targeting regions,True,assigned_and_evaluated +11192,88252,17.063478,0.90625,WD repeat,keyword,49061,WD40/YVTN repeat-like-containing domain superfamily,0.90283203,115,keywords,WD repeat,keyword:keywords:WD repeat,28.0,2257.0,0.8903015445747613,0.05237150225776792,0.012405848471422242,,4.221517164135078,0.0,15.0,0.0,1.0,Hydrophobic beta-strand segments,True,assigned_and_evaluated +11193,59229,26.093311,0.7685547,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7685547,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7465065587170605,0.2947317217944355,0.0101905183872397,0.391304347826087,28.92215200391482,11.0,15.0,77.9359477124183,1.5712756810227858e-19,N-terminal helical interaction module,True,assigned_and_evaluated +11194,47717,18.475435,0.9765625,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.70996094,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,13.0,15.0,237.02538226299694,5.697816754768172e-30,SF2 helicase interdomain hinge,True,assigned_too_few_test_positives +11195,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal scaffold,False,no_term_above_threshold +11196,47529,19.75063,0.8496094,Immunoglobulin-like fold,interpro,88058,Signal,0.6040039,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7713213966979027,0.05823692792257997,0.007089056269384138,,8.215046645078937,0.0,18.0,0.0,1.0,Surface-exposed strand-edge residues,True,assigned_and_evaluated +11197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminal cap activation,False,no_term_above_threshold +11198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDR signal,False,no_term_above_threshold +11199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge nuclear linker IDRs,False,no_term_above_threshold +11200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic nucleic acid interface,False,no_term_above_threshold +11201,85364,28.3396,0.9736328,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9736328,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,11.0,16.0,207.01736111111111,5.180645293831427e-24,Ligand-binding cleft β-strands,True,assigned_too_few_test_positives +11202,64475,15.902411,0.8857422,ACP-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6245117,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9211915535444948,0.8026612799626671,0.0057598582188746125,0.7692307692307693,139.35434683659537,0.0,16.0,0.0,1.0,Winged-helix GY hinge motif,True,assigned_and_evaluated +11203,37020,16.579744,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,18.0,725.9786910197869,1.266441663928211e-44,Glycosyltransferase EAM-P loop,True,assigned_too_few_test_positives +11204,36010,19.925064,0.9873047,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9423828,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,1.0,17.0,29.975364504776273,0.05452746967168221,AB-hydrolase N-terminal cap/lid,True,assigned_too_few_test_positives +11205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-binding motifs with disordered flanks,False,no_term_above_threshold +11206,36115,16.16011,0.7885742,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7836914,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,20.0,0.0,1.0,P-loop helical coupling module,True,assigned_too_few_test_positives +11207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-strand-loop signature,False,no_term_above_threshold +11208,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core packing residues,False,no_term_above_threshold +11209,50869,17.179907,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.6777344,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,19.0,19.0,917.2461538461538,1.6344645258281847e-55,Sequence-specific DNA recognition helix,True,assigned_too_few_test_positives +11210,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory carbohydrate-binding surfaces,False,no_term_above_threshold +11211,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal amphipathic interface segments,False,no_term_above_threshold +11212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEPS/PPDK conserved motif,False,no_term_above_threshold +11213,87857,22.738531,0.6303711,Nucleus,keyword,87857,Nucleus,0.6303711,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6352796659024789,0.26338683864008633,0.06247230837394772,0.24113475177304963,4.216057410004786,18.0,19.0,5.7401476251604615,2.930157346962097e-13,Nuclear phospho-regulated Ser/Thr-rich IDRs,True,assigned_and_evaluated +11214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,OB/Sm nucleic-acid binding barrels,False,no_term_above_threshold +11215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical scaffolds with disordered tails,False,no_term_above_threshold +11216,87239,16.632643,0.7597656,CF(1),keyword,87239,CF(1),0.7597656,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9995529727313366,0.8724409180001285,0.008861320336730172,1.0,98.4549575963145,2.0,18.0,89.52102102102101,0.00041316515230091684,PRD and cell-wall-binding repeats,True,assigned_and_evaluated +11217,46079,23.92672,0.86816406,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.86816406,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9383655560126147,0.11329649536453594,0.0057598582188746125,,19.67001461828905,0.0,20.0,0.0,1.0,Acidic amphipathic PPI helices,True,assigned_and_evaluated +11218,52236,23.725416,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9897461,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,15.0,223.29962546816478,2.087522942442783e-35,TPR helical register marker,True,assigned_too_few_test_positives +11219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core alpha/beta structural blocks,False,no_term_above_threshold +11220,59211,19.53097,0.7294922,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7294922,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9386379928315411,0.8432339599552715,0.011076650420912717,0.88,76.1271619047619,15.0,15.0,244.34836065573774,5.455051084820287e-36,NTase Rossmann NTP-binding segment,True,assigned_and_evaluated +11221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal helical scaffold block,False,no_term_above_threshold +11222,37071,18.041775,0.97509766,Homeodomain,interpro,87384,DNA-binding,0.63671875,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,14.0,15.0,192.54763552479815,1.7802095629629327e-31,N-terminal transcriptional regulatory IDRs,True,assigned_too_few_test_positives +11223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal lipase membrane lid,False,no_term_above_threshold +11224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interfacial loops and caps,False,no_term_above_threshold +11225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma/HTH promoter-recognition helices,False,no_term_above_threshold +11226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N/Q-rich low-complexity IDRs,False,no_term_above_threshold +11227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ribosomal uL4 N-terminus,False,no_term_above_threshold +11228,87326,23.666035,0.6689453,Coiled coil,keyword,87326,Coiled coil,0.6689453,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6278789543513412,0.08765760498766166,0.03943287549844927,0.011235955056179775,2.2229574658107008,1.0,19.0,0.6635541062425571,1.0,Histidine kinase helical core,True,assigned_and_evaluated +11229,12207,18.998331,0.9238281,transposition,go_bp,88164,Transposition,0.9238281,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,1.0,14.0,92.57919254658385,0.018316933981073206,Helical polyanion-binding patch,True,assigned_too_few_test_positives +11230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix N-terminal entry,False,no_term_above_threshold +11231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-solenoid repeat architecture,False,no_term_above_threshold +11232,38873,20.63497,0.8461914,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.69384766,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9994671403197158,0.7961904761904761,0.002215330084182543,1.0,359.40038095238094,11.0,11.0,171.32471264367817,6.880872708632078e-25,ABC NBD Q-loop beta-strand,True,assigned_and_evaluated +11233,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial beta-loop scaffolds,False,no_term_above_threshold +11234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic His-rich active-site loop,False,no_term_above_threshold +11235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lectin-like extracellular binding domains,False,no_term_above_threshold +11236,30398,15.989604,0.8300781,ATP hydrolysis activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.82421875,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6940824091313851,0.010479534446809557,0.004873726185201595,,2.1502099314953793,8.0,11.0,52.36802810715854,4.750539111493361e-13,P-loop NTPase catalytic switches,True,assigned_and_evaluated +11237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed loop/strand microenvironments,False,no_term_above_threshold +11238,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical solenoid catalytic interface,False,no_term_above_threshold +11239,81858,19.65626,0.9394531,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6459961,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,Aromatic-basic TM helix anchors,True,assigned_too_few_test_positives +11240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-export N-terminal domain transition,False,no_term_above_threshold +11241,84152,17.785343,0.97998047,Metal-dependent hydrolases,gene3d,47531,Aldolase-type TIM barrel,0.96240234,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,18.0,0.0,1.0,Catalytic pocket scaffold residues,True,assigned_too_few_test_positives +11242,82029,27.121845,0.99853516,MFS general substrate transporter like domains,gene3d,88162,Transport,0.6088867,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,MFS TM5/TM11 helix-kink hinges,True,assigned_too_few_test_positives +11243,87276,39.1633,0.6689453,Cell membrane,keyword,88161,Transmembrane helix,0.6430664,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7166031785122718,0.4700469265571976,0.11120957022596367,0.4581673306772908,4.226676945177669,5.0,18.0,2.2792993240970123,0.09689827921044603,Pre-TM1 signal-anchor,True,assigned_and_evaluated +11244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal IDRs with secretion signals,False,no_term_above_threshold +11245,87857,21.2357,0.64697266,Nucleus,keyword,87857,Nucleus,0.64697266,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6063645443698132,0.11121353087168563,0.06247230837394772,,1.7802052423928687,14.0,20.0,4.241331300813008,3.083494805344978e-07,Disordered KR-rich NLS-like motifs,True,assigned_and_evaluated +11246,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic loop–TM junction hotspot,False,no_term_above_threshold +11247,36535,23.264305,0.9682617,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9560547,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9491544281263908,0.8904430660168364,0.004430660168365086,0.9,200.97299999999998,15.0,15.0,89.79066265060241,1.585928718533337e-29,Kinase N-lobe β3���αC segment,True,assigned_and_evaluated +11248,47529,28.16482,0.9765625,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9765625,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.998340584560464,0.761069057965511,0.007089056269384138,1.0,107.35830398925991,12.0,15.0,61.86355382619975,2.3099486149522623e-20,Short beta-strand loop clusters,True,assigned_and_evaluated +11249,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization segments,False,no_term_above_threshold +11250,45553,16.942461,0.8564453,Restriction endonuclease type II-like,interpro,45553,Restriction endonuclease type II-like,0.8564453,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,4.0,18.0,152.28863346104725,2.552616296332662e-08,Nucleic acid interaction helices,True,assigned_too_few_test_positives +11251,88161,63.764473,0.7265625,Transmembrane helix,keyword,88161,Transmembrane helix,0.7265625,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7889121311646337,0.6251704739940777,0.1847585290208241,0.657074340527578,3.3837164503708235,19.0,19.0,5.4274920345926265,2.5090631899926267e-14,TM1-TM2 helix-loop junction,True,assigned_and_evaluated +11252,87697,16.097849,0.8330078,Knottin,keyword,87413,Disulfide bond,0.6777344,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9172735890499641,0.09577252675810861,0.017279574656623838,,5.542528022898747,0.0,16.0,0.0,1.0,GH81 hydrophobic beta-strand motif,True,assigned_and_evaluated +11253,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long acidic low-complexity IDRs,False,no_term_above_threshold +11254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal head,False,no_term_above_threshold +11255,81799,18.188538,0.8227539,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.60791016,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,5.0,6.0,482.3705501618123,1.8813078624289315e-13,AAA+ P-loop flanking motifs,True,assigned_too_few_test_positives +11256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent alpha-helix,False,no_term_above_threshold +11257,63831,19.719269,0.9267578,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9267578,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7607359691988745,0.007513069411093553,0.002658396101019052,,2.826166276806358,0.0,16.0,0.0,1.0,Phosphate-binding amphipathic helix,True,assigned_and_evaluated +11258,46932,27.341085,0.86083984,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.86083984,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.8943035157988428,0.636698489013078,0.004430660168365086,0.6,143.70284897025172,13.0,17.0,82.74506245329347,2.0573815815323336e-23,C-terminal disordered regulatory tails,True,assigned_and_evaluated +11259,61392,19.737146,0.99365234,Leucine-rich repeat domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.77783203,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9863174603174603,0.2359280226586423,0.0031014621178555605,0.14285714285714285,76.06993530579366,9.0,16.0,94.20452949438203,2.305806436273608e-16,Conserved hydrophobic beta-strands,True,assigned_and_evaluated +11260,63831,18.40492,0.88378906,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.88378906,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9686805864060418,0.04549013518170386,0.002658396101019052,,17.1118725175176,0.0,17.0,0.0,1.0,Inter-repeat linker turns,True,assigned_and_evaluated +11261,81799,17.476059,0.8701172,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.60595703,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,0.0,20.0,0.0,1.0,P-loop NTPase transducer helices,True,assigned_too_few_test_positives +11262,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor N-cap beta-loop-helix junctions,False,no_term_above_threshold +11263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal zinc-binding loop,False,no_term_above_threshold +11264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenine-nucleotide binding lid,False,no_term_above_threshold +11265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent phospho/sulfate catalysis,False,no_term_above_threshold +11266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helical stalks,False,no_term_above_threshold +11267,87882,18.809635,0.6489258,Palmitate,keyword,87882,Palmitate,0.6489258,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.6571893973049014,0.027210860558574104,0.002658396101019052,,10.235818713450291,1.0,18.0,3.700869025450031,0.37504415834733396,Signal peptides and sortase anchors,True,assigned_and_evaluated +11268,87276,32.06076,0.6386719,Cell membrane,keyword,88161,Transmembrane helix,0.625,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7380537669858949,0.5070878561196418,0.11120957022596367,0.5099601593625498,4.559750164390564,17.0,19.0,7.341743086038797,8.654145245761993e-14,Kinked transmembrane helices,True,assigned_and_evaluated +11269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTPase and protease catalytic cores,False,no_term_above_threshold +11270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane disordered linker,False,no_term_above_threshold +11271,87149,23.063248,0.6933594,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6933594,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7361404858040119,0.06662210167630375,0.012405848471422242,,5.370217267264913,0.0,20.0,0.0,1.0,Short glycine/alanine-rich membrane helices,True,assigned_and_evaluated +11272,36914,23.594221,0.9604492,Glycosyltransferase 2-like,interpro,81685,Transferase(Phosphotransferase) domain 1,0.91259766,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,13.0,0.0,1.0,Protein kinase activation loop,True,assigned_too_few_test_positives +11273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane regions,False,no_term_above_threshold +11274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular assembly and N-terminal maturation,False,no_term_above_threshold +11275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site lid/cofactor segment,False,no_term_above_threshold +11276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metalloprotease C-terminal cap,False,no_term_above_threshold +11277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix cap hairpin,False,no_term_above_threshold +11278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure transition hinges,False,no_term_above_threshold +11279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrolase subdomain activation,False,no_term_above_threshold +11280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant IDRs flanking structured domains,False,no_term_above_threshold +11281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory input/sensor interfaces,False,no_term_above_threshold +11282,83419,19.227613,0.9902344,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9785156,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,16.0,19.0,306.1412066752246,3.3556839336594273e-38,Aromatic beta-strand binding patches,True,assigned_too_few_test_positives +11283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-start lid/hairpin loops,False,no_term_above_threshold +11284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P/S/T-rich low-complexity regions,False,no_term_above_threshold +11285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic coiled-coil hairpins,False,no_term_above_threshold +11286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Subtilisin acidic catalytic leg,False,no_term_above_threshold +11287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Heptad-repeat coiled-coils,False,no_term_above_threshold +11288,37020,16.127274,0.98291016,"Glycosyl transferase, family 1",interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9736328,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,14.0,0.0,1.0,SAM pocket flanking beta strand,True,assigned_too_few_test_positives +11289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-solenoid junction linker motif,False,no_term_above_threshold +11290,87413,16.75402,0.62890625,Disulfide bond,keyword,87413,Disulfide bond,0.62890625,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5631382774978637,0.07462787839635926,0.0717766947275144,,1.0397229724727337,6.0,12.0,5.913608411029558,0.0003874671981213149,Conserved TAFA/SELENOT motif residues,True,assigned_and_evaluated +11291,81858,18.676836,0.98046875,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.60009766,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,11.0,19.0,151.39219759926132,4.056012985964278e-22,GPCR ECL3–TM7 activation hotspot,True,assigned_too_few_test_positives +11292,43583,18.515512,0.9941406,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9941406,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,17.0,18.0,393.7672882672882,3.009625101645989e-43,Chymotrypsin-like active-site loop,True,assigned_and_evaluated +11293,64620,17.849966,0.96533203,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8432617,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,19.0,19.0,324.0271739130435,2.7035397615707734e-47,CA domain ATP-lid helix,True,assigned_too_few_test_positives +11294,87326,25.908997,0.64697266,Coiled coil,keyword,87326,Coiled coil,0.64697266,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6380913387785564,0.2615853501499861,0.03943287549844927,0.2696629213483146,6.633686913354142,19.0,19.0,12.607528018608585,3.1804487015974775e-21,Charge-rich SAH-like helices,True,assigned_and_evaluated +11295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leu/Met-rich midchain motif detector,False,no_term_above_threshold +11296,49236,19.615011,0.90625,C-type lectin fold,interpro,63831,F-box-like domain superfamily,0.7001953,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9993783303730017,0.81,0.002215330084182543,1.0,365.63400000000007,4.0,15.0,144.53575757575757,2.9502595028801198e-08,Trp-Glu exosite helix,True,assigned_and_evaluated +11297,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-catalytic cyclase tails/linkers,False,no_term_above_threshold +11298,58239,16.337936,0.72021484,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.72021484,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8525372124492558,0.07873347140759616,0.017722640673460344,,4.442536124173614,12.0,13.0,33.093667607197375,6.685098697812748e-18,Noncatalytic nucleotide-binding helical scaffold,True,assigned_and_evaluated +11299,37020,17.709805,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,13.0,17.0,624.5551974214343,5.471029150974689e-35,Glycosyltransferase donor-binding beta-strand,True,assigned_too_few_test_positives +11300,88161,35.88435,0.66845703,Transmembrane helix,keyword,88161,Transmembrane helix,0.66845703,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.699420680846627,0.47277897970561034,0.1847585290208241,0.4052757793764988,2.5589020556248503,19.0,19.0,5.4274920345926265,2.5090631899926267e-14,Aromatic-anchored transmembrane helices,True,assigned_and_evaluated +11301,82029,23.477184,0.77246094,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.7714844,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,18.0,188.0788643533123,6.824310871704072e-41,MFS TM11-12 periplasmic loop,True,assigned_too_few_test_positives +11302,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity IDRs and propeptides,False,no_term_above_threshold +11303,37894,17.865705,0.84765625,Short-chain dehydrogenase/reductase SDR,interpro,38317,Pentatricopeptide repeat,0.75146484,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Extracellular repeat consensus residues,True,assigned_too_few_test_positives +11304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate binding cores and switches,False,no_term_above_threshold +11305,82029,32.26325,1.0,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS Motif A N-caps,True,assigned_too_few_test_positives +11306,26421,16.177319,0.7006836,proton-transporting ATP synthase complex,go_cc,26421,proton-transporting ATP synthase complex,0.7006836,80,go,GO:0045259,go_cc:go:GO:0045259,23.0,2257.0,0.9482211669456231,0.13210672787930636,0.0101905183872397,,12.963690644504105,0.0,14.0,0.0,1.0,Transmembrane helix entry motifs,True,assigned_and_evaluated +11307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-nucleophile segment,False,no_term_above_threshold +11308,4066,24.861458,0.9277344,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.9277344,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7929840142095915,0.30543158657912756,0.002215330084182543,0.2,137.87181818181818,0.0,15.0,0.0,1.0,Metal-dependent nuclease cores,True,assigned_and_evaluated +11309,38890,23.60489,0.92041016,HNH nuclease,interpro,38890,HNH nuclease,0.92041016,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,9.0,19.0,613.9462242562929,1.1210716336282209e-23,Charged HNH catalytic helix,True,assigned_too_few_test_positives +11310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGRxSAR FMN-binding loop,False,no_term_above_threshold +11311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic packing alpha-helix,False,no_term_above_threshold +11312,55053,20.705238,0.98535156,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,10.0,10.0,552.0462962962963,8.365098670586762e-28,NRPS C-domain beta-strand motif,True,assigned_too_few_test_positives +11313,85649,35.63363,0.9667969,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96484375,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9082168852905688,0.732216428588564,0.0101905183872397,0.6956521739130435,71.85271649236472,12.0,13.0,102.10532324818038,9.896673303892203e-24,SAM Rossmann-like catalytic core,True,assigned_and_evaluated +11314,50338,16.873964,0.9814453,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6435547,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,10.0,0.0,1.0,Transmembrane helical transporters,True,assigned_too_few_test_positives +11315,47529,18.030563,0.88720703,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.88720703,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8661730254350735,0.060453809348096035,0.007089056269384138,,8.527765481165797,0.0,20.0,0.0,1.0,Beta-strand edge turns,True,assigned_and_evaluated +11316,85675,17.836174,0.9326172,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.91308594,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,19.0,20.0,519.6325688073395,3.950730690425156e-50,Pro/Thr-rich disordered linkers,True,assigned_too_few_test_positives +11317,85364,17.774736,0.70947266,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.70947266,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,20.0,255.94873737373737,3.1365718675403606e-39,Periplasmic solute binding domains,True,assigned_too_few_test_positives +11318,85672,22.299105,0.62060547,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61376953,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5253139226574616,0.0474716519798487,0.01595037660611431,0.027777777777777776,2.9762088477366255,12.0,12.0,40.01409395973155,1.4584552891973136e-19,SF1/SF2 helicase ATPase core,True,assigned_and_evaluated +11319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Frizzled CRD helical segment,False,no_term_above_threshold +11320,87882,32.0991,0.8955078,Palmitate,keyword,88058,Signal,0.68115234,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9991855471642233,0.7577380952380952,0.002658396101019052,1.0,285.0358134920635,20.0,20.0,66.61564245810055,1.5919415596255537e-36,Bacterial signal peptide h-region,True,assigned_and_evaluated +11321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β-hairpin scaffold,False,no_term_above_threshold +11322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Y-complex nucleoporin helical scaffold,False,no_term_above_threshold +11323,46929,19.596004,0.8051758,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.7001953,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.6838809946714033,0.023307220028531504,0.002215330084182543,,10.52087912087912,16.0,18.0,76.36375280179314,5.128989272994484e-29,Non-catalytic chromatin interaction regions,True,assigned_and_evaluated +11324,43583,15.977896,0.9082031,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9082031,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,0.9961547802153323,0.5231556008038222,0.004873726185201595,0.5454545454545454,107.3420173649297,3.0,16.0,78.1743881118881,1.3858813684611982e-05,Extracytoplasmic beta-sandwich loop edges,True,assigned_and_evaluated +11325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan processing juxtamembrane loops,False,no_term_above_threshold +11326,85682,19.261671,0.6875,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6875,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8566577060931899,0.5166061983161435,0.011076650420912717,0.72,46.63920758398143,10.0,10.0,102.26586620926243,1.9453282264469492e-20,Rossmann pre-cofactor-loop region,True,assigned_and_evaluated +11327,48255,18.715342,0.80371094,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.80371094,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,6.0,13.0,157.2421978021978,2.1765586109107786e-12,C-terminal regulatory segments,True,assigned_too_few_test_positives +11328,85762,35.506027,0.9682617,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9580078,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,11.0,14.0,161.5347290640394,3.053136486659107e-23,FAD-binding loop-helix motif,True,assigned_too_few_test_positives +11329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional core transmembrane helices,False,no_term_above_threshold +11330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-tail motif,False,no_term_above_threshold +11331,48883,21.014154,0.96240234,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.96240234,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,6.0,12.0,240.4072580645161,1.4779718747578026e-13,C-terminal active-site gating segments,True,assigned_too_few_test_positives +11332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor and disordered loops,False,no_term_above_threshold +11333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal nucleotide-binding scaffold,False,no_term_above_threshold +11334,55053,16.048182,0.79589844,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.79589844,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,15.0,0.0,1.0,Diffuse whole-chain mid-peak,True,assigned_too_few_test_positives +11335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic carbohydrate cleft scaffolds,False,no_term_above_threshold +11336,59224,22.414663,0.7036133,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.7036133,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.8494603174603175,0.11711018575772673,0.0031014621178555605,,37.75966989359846,12.0,12.0,137.37557603686636,5.966399334974262e-26,Lipid-enzyme active-site lid,True,assigned_and_evaluated +11337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed beta/alpha-to-coil hinges,False,no_term_above_threshold +11338,37894,18.757399,0.83447266,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.83447266,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,11.0,0.0,1.0,C-terminal acetyltransferase binding tails,True,assigned_too_few_test_positives +11339,38873,17.965572,0.72998047,AAA+ ATPase domain,interpro,30398,ATP hydrolysis activity,0.6401367,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7980461811722913,0.5208861320336731,0.002215330084182543,0.6,235.12800000000004,8.0,8.0,171.32471264367817,3.093783670371934e-18,ABC NBD C-terminal tail activation,True,assigned_and_evaluated +11340,59224,21.48495,0.72216797,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.72216797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7726031746031745,0.05658584616430049,0.0031014621178555605,,18.244893541832315,11.0,16.0,94.44570852534562,2.962253532649377e-20,Hydrolase-flanking regulatory IDRs,True,assigned_and_evaluated +11341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved ADAR dsRBM/editase signatures,False,no_term_above_threshold +11342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Gly/Pro catalytic motifs,False,no_term_above_threshold +11343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small hydrophobics in alpha-helices,False,no_term_above_threshold +11344,87968,16.097523,0.6933594,Protein biosynthesis,keyword,87968,Protein biosynthesis,0.6933594,81,keywords,Protein biosynthesis,keyword:keywords:Protein biosynthesis,7.0,2257.0,0.8503492063492064,0.16038377724560396,0.0031014621178555605,,51.7123121776183,10.0,11.0,167.80467210807768,5.676693489804425e-22,Basic terminal interaction helices,True,assigned_and_evaluated +11345,31094,17.1657,0.96484375,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.82128906,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9987538940809969,0.7144715956558062,0.004430660168365086,1.0,161.25623913951546,9.0,17.0,375.7626050420168,9.22141500893519e-22,Ketosynthase β-strand core activation,True,assigned_and_evaluated +11346,37446,26.626078,0.90527344,F-box domain,interpro,63831,F-box-like domain superfamily,0.90478516,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9948571428571429,0.372510636361568,0.0031014621178555605,0.14285714285714285,120.10807232400842,17.0,20.0,197.96035156249997,2.368875867757361e-37,LRR loop-to-helix N-cap,True,assigned_and_evaluated +11347,38878,18.055399,0.97558594,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.7734375,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,0.0,14.0,0.0,1.0,Periodic ectodomain acidic/polar patches,True,assigned_too_few_test_positives +11348,38873,16.610416,0.7832031,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7807617,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.5953818827708702,0.04177226406734604,0.002215330084182543,,18.856000000000005,3.0,16.0,32.12338362068966,0.00019002477331739746,P-loop NTPase ATP-binding site,True,assigned_and_evaluated +11349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal secretory signal activation,False,no_term_above_threshold +11350,82029,21.36201,0.99560547,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7426758,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,18.0,156.7323869610936,1.8278507282603615e-31,Transmembrane helix capping hinges,True,assigned_too_few_test_positives +11351,59224,17.78012,0.95751953,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77978516,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9821904761904761,0.10478163925168535,0.0031014621178555605,,33.78459425586483,1.0,15.0,9.158371735791091,0.16775931673620395,Conserved cofactor-binding loop motifs,True,assigned_and_evaluated +11352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Winged-helix/HTH DNA-binding modules,False,no_term_above_threshold +11353,87586,18.771013,0.6928711,Host membrane,keyword,88161,Transmembrane helix,0.63720703,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7769600681762845,0.1660815579709387,0.01639344262295082,,10.13097503622726,3.0,19.0,10.199178878941666,0.005153824635592767,Acidic low-complexity linkers,True,assigned_and_evaluated +11354,36977,18.065691,0.96777344,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.8769531,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,2.0,16.0,38.815755208333336,0.0021032556583340353,Kinase N-lobe HDx-Gx motif,True,assigned_too_few_test_positives +11355,25169,16.209103,0.7651367,pilus,go_cc,25169,pilus,0.7651367,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.6873001776198935,0.027908718747677284,0.002215330084182543,,12.597995642701527,3.0,18.0,92.00771604938271,8.716043774821798e-06,Exposed N-terminal nucleic-acid interfaces,True,assigned_and_evaluated +11356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NuoF beta-alpha junction motif,False,no_term_above_threshold +11357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAS10/UTP3 LxxKESPEL motif,False,no_term_above_threshold +11358,88058,21.991892,0.63671875,Signal,keyword,88058,Signal,0.63671875,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6299235987181246,0.11352367443732006,0.09127159946832078,,1.2438006466263658,5.0,19.0,1.8960407059945936,0.1813522347006305,S/G/P/R-rich low-complexity tracts,True,assigned_and_evaluated +11359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trimeric spike shaft interfaces,False,no_term_above_threshold +11360,29104,19.449406,0.7109375,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.6953125,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,12.0,12.0,428.9280575539568,6.72820626905281e-32,Antiporter-like core TM helix activation,True,assigned_too_few_test_positives +11361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long intrinsically disordered linkers,False,no_term_above_threshold +11362,85656,33.629444,0.80322266,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.8022461,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8522222222222223,0.4560143371618781,0.0031014621178555605,0.42857142857142855,147.03205128205127,13.0,13.0,141.281990521327,3.1965736954515104e-28,ABH serine hydrolase domain,True,assigned_and_evaluated +11363,84991,15.656878,0.97998047,3.30.70.20,gene3d,37071,Homeodomain,0.94873047,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,0.0,17.0,0.0,1.0,Conserved hydrophobic SAM-binding residue,True,assigned_too_few_test_positives +11364,87274,21.487707,0.76953125,Cell inner membrane,keyword,88161,Transmembrane helix,0.75390625,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.9465323166303558,0.7053633057056433,0.0358883473637572,0.7037037037037037,19.654382481205396,10.0,18.0,21.663033209795802,9.417895312861324e-12,Pore-lining and anchor helices,True,assigned_and_evaluated +11365,52236,24.859549,0.9970703,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.95654297,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,16.0,223.29962546816478,1.0796101345399494e-37,TPR/SEL1 small-residue helix packing,True,assigned_too_few_test_positives +11366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic beta-strand motif,False,no_term_above_threshold +11367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding loops,False,no_term_above_threshold +11368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase/serpin catalytic core grooves,False,no_term_above_threshold +11369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL/HATPase_c ATPase core,False,no_term_above_threshold +11370,87108,17.133202,0.93310547,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.9248047,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9387850929221035,0.03552590972871479,0.003987594151528578,,8.909108695301033,0.0,15.0,0.0,1.0,Glycine secondary-structure hinges,True,assigned_and_evaluated +11371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KS3 ketosynthase LTxARE motif,False,no_term_above_threshold +11372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NiFe hydrogenase catalytic core,False,no_term_above_threshold +11373,48255,19.015135,0.87109375,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.87109375,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,14.0,14.0,340.69142857142856,1.1186263779464597e-35,PP-loop adenylation site,True,assigned_too_few_test_positives +11374,38873,15.934128,0.9868164,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.93408203,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9980461811722913,0.41631701631701634,0.002215330084182543,0.6,187.9255011655012,12.0,17.0,120.93509127789048,2.2316418537937037e-23,Walker B catalytic carboxylates,True,assigned_and_evaluated +11375,50338,15.920088,0.8354492,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.78466797,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Transporter TM helix N-cap,True,assigned_too_few_test_positives +11376,36535,17.446056,0.97021484,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.953125,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9988429016466399,0.9277777777777777,0.004430660168365086,0.9,209.39944444444444,12.0,12.0,89.79066265060241,9.608590434204234e-24,APE/P+1 activation segment,True,assigned_and_evaluated +11377,63831,21.42398,0.93115234,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.93115234,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8753887161261661,0.013590865903263106,0.002658396101019052,,5.112430723944138,0.0,16.0,0.0,1.0,Charged helical surfaces in oxidoreductases,True,assigned_and_evaluated +11378,55054,28.173883,0.98583984,HAD superfamily,interpro,55054,HAD superfamily,0.98583984,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8967584369449378,0.43710973268350317,0.002215330084182543,0.6,197.31133333333335,15.0,15.0,334.9494382022472,4.957857297918448e-38,ISN1 substrate-binding helix motif,True,assigned_and_evaluated +11379,37468,26.86898,0.99658203,"Zinc finger, RING-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.99658203,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,16.0,18.0,122.11162314388119,3.0732423888066364e-32,RING E3 ligase domain,True,assigned_too_few_test_positives +11380,50763,17.830805,0.9038086,"Zinc finger, RING-type, conserved site",interpro,87465,Fimbrium,0.8701172,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,19.0,0.0,1.0,Pro-Gly beta-turn linkers,True,assigned_too_few_test_positives +11381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single hydrophobic TM helix,False,no_term_above_threshold +11382,45551,22.100132,0.9975586,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9975586,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,15.0,19.0,268.9669172932331,1.073930796546143e-34,Post-BTB helical linker,True,assigned_too_few_test_positives +11383,85664,22.753616,0.9707031,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9707031,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,N-terminal membrane-anchoring motif,True,assigned_too_few_test_positives +11384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic N-terminal amphipathic segments,False,no_term_above_threshold +11385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking switch loops,False,no_term_above_threshold +11386,49236,20.457926,0.92529297,C-type lectin fold,interpro,49236,C-type lectin fold,0.92529297,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,3.0,15.0,108.40181818181819,5.1898590483991615e-06,Aromatic loop-tip binding site,True,assigned_and_evaluated +11387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge flexible surface loops,False,no_term_above_threshold +11388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane modules,False,no_term_above_threshold +11389,82716,17.295486,0.9863281,Laminin,gene3d,87413,Disulfide bond,0.7338867,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,18.0,18.0,289.42233009708735,4.0738218914291243e-44,Extracellular cysteine-rich repeat modules,True,assigned_too_few_test_positives +11390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil/alpha-solenoid scaffolds,False,no_term_above_threshold +11391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MBL substrate entry helix,False,no_term_above_threshold +11392,38317,18.76886,0.94921875,Pentatricopeptide repeat,interpro,88154,Transit peptide,0.94384766,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.906888888888889,0.09030509778606594,0.0031014621178555605,,29.116943671878687,0.0,18.0,0.0,1.0,N-terminal presequence cleavage signal,True,assigned_and_evaluated +11393,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue coil/turn micro-motifs,False,no_term_above_threshold +11394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal non-domain extensions,False,no_term_above_threshold +11395,87326,18.92425,0.67529297,Coiled coil,keyword,87326,Coiled coil,0.67529297,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7193343422198267,0.10803312774803027,0.03943287549844927,0.02247191011235955,2.7396715654753296,4.0,18.0,2.80167289302413,0.08112775501689559,Spire KIND/WH2 with charged LCRs,True,assigned_and_evaluated +11396,39958,26.75061,0.92041016,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.92041016,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.998223011994669,0.4362433862433863,0.002658396101019052,1.0,164.10022045855382,0.0,13.0,0.0,1.0,Nucleotidyl cyclase/PDE catalytic motifs,True,assigned_and_evaluated +11397,85672,38.404953,0.9658203,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.96533203,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.926509580269148,0.6405907283504845,0.01595037660611431,0.75,40.16147983019565,14.0,14.0,40.01409395973155,9.778128717856954e-23,P-loop NTPase sensor motifs,True,assigned_and_evaluated +11398,36914,27.172314,0.99853516,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.85498047,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,18.0,0.0,1.0,GHKL ATP-binding acidic residue,True,assigned_too_few_test_positives +11399,84753,20.420773,0.77001953,3.30.420.40,gene3d,84753,3.30.420.40,0.77001953,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,15.0,16.0,388.1575520833333,2.8896605394056896e-38,Sugar kinase catalytic cores,True,assigned_too_few_test_positives +11400,36354,19.618383,0.9995117,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9921875,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,19.0,19.0,214.4640287769784,4.784892647572837e-44,RRM beta-strand aromatic hotspot,True,assigned_too_few_test_positives +11401,87601,18.062784,0.6347656,Hydrolase,keyword,88058,Signal,0.6035156,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6251286850725316,0.14293894517930703,0.05316792202038104,,2.6884433272474664,8.0,18.0,4.970591300360574,0.00014283300917095136,Active-site motif edge detector,True,assigned_and_evaluated +11402,45290,32.77512,0.9707031,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9707031,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9602187028657617,0.8807849463587168,0.0057598582188746125,0.8461538461538461,152.91781722550954,17.0,17.0,73.42487684729065,6.829036441178294e-32,Juxta-kinase regulatory segment,True,assigned_and_evaluated +11403,45290,29.93363,0.9736328,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9736328,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.959841628959276,0.9235199890937597,0.0057598582188746125,0.9230769230769231,160.33727810650888,17.0,17.0,73.42487684729065,6.829036441178294e-32,Ser/Thr kinase N-lobe motif,True,assigned_and_evaluated +11404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal disordered segment,False,no_term_above_threshold +11405,31094,15.943591,0.9506836,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.80810547,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9989541611036938,0.6652669552669552,0.004430660168365086,1.0,150.1507518037518,0.0,17.0,0.0,1.0,Conserved AAA+/P-loop hotspots,True,assigned_and_evaluated +11406,88023,15.7144,0.7084961,Ribosome biogenesis,keyword,88023,Ribosome biogenesis,0.7084961,90,keywords,Ribosome biogenesis,keyword:keywords:Ribosome biogenesis,34.0,2257.0,0.9693313222724987,0.8681089694935303,0.015064244572441293,0.9411764705882353,57.62711600432053,5.0,14.0,56.78190476190476,3.6577071263274175e-08,"Diffuse ribosome-associated activation, internal peaks",True,assigned_and_evaluated +11407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad structured domain activation,False,no_term_above_threshold +11408,58239,21.979073,0.6298828,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6298828,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6214817320703654,0.17027249998561475,0.017722640673460344,0.2,9.607625811688314,15.0,16.0,33.61075616355983,1.95430617609731e-22,P-loop motor ATPase core,True,assigned_and_evaluated +11409,88161,32.668808,0.6640625,Transmembrane helix,keyword,88161,Transmembrane helix,0.6640625,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6857268532999687,0.379406633340887,0.1847585290208241,0.2685851318944844,2.053527029857031,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,GPCR-enriched transmembrane helix residue detector,True,assigned_and_evaluated +11410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional-site proximal hinge loops,False,no_term_above_threshold +11411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic alpha-helices,False,no_term_above_threshold +11412,88164,17.711643,0.99072266,Transposition,keyword,88163,Transposable element,0.7807617,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.9992007104795737,0.8714285714285714,0.002215330084182543,0.8,393.3628571428572,2.0,18.0,80.78726287262872,0.0005061710321082204,Acidic catalytic/metal-binding motifs,True,assigned_and_evaluated +11413,88160,15.58232,0.82666016,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6933594,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Outer membrane beta-barrel pores,True,assigned_too_few_test_positives +11414,47529,27.375126,0.92626953,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.92626953,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.92793395805444,0.33457777779695036,0.007089056269384138,0.375,47.19637778048231,5.0,17.0,22.743953612573435,3.7029494264875065e-06,Contiguous beta-strand segments,True,assigned_and_evaluated +11415,31094,16.764416,0.9658203,phosphopantetheine binding,go_mf,85682,NAD(P)-binding Rossmann-like Domain,0.78466797,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9472185135736537,0.4495303676041381,0.004430660168365086,0.7,101.45900396825398,0.0,15.0,0.0,1.0,KGxPGE GP-rich SDR loop,True,assigned_and_evaluated +11416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter coupling helix,False,no_term_above_threshold +11417,45324,23.513634,0.98046875,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.98046875,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,13.0,19.0,374.25060357315306,1.357157101892521e-31,G8-like extracellular beta domain,True,assigned_and_evaluated +11418,39971,16.618135,0.75683594,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,39971,"Calcineurin-like phosphoesterase domain, ApaH type",0.75683594,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,Catalytic β–loop–α module,True,assigned_too_few_test_positives +11419,47128,28.317394,0.93652344,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.93652344,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,11.0,13.0,217.45059681697612,5.701679593821027e-25,GH16 fold-wide activation,True,assigned_too_few_test_positives +11420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter NBD motifs,False,no_term_above_threshold +11421,80926,16.001001,0.84716797,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.8461914,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.9276189496777733,0.11896143944947081,0.0057598582188746125,,20.65353606441966,1.0,17.0,5.611388235294117,0.26043635940455007,Hydrophobic/aromatic core packing,True,assigned_and_evaluated +11422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protease zymogen propeptides,False,no_term_above_threshold +11423,87413,52.185047,0.87841797,Disulfide bond,keyword,87413,Disulfide bond,0.87841797,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.8967662571083415,0.5180520372495008,0.0717766947275144,0.7592592592592593,7.217552148593353,15.0,18.0,9.856014018382597,1.1446711897836568e-13,Mature secreted extracellular segments,True,assigned_and_evaluated +11424,36914,18.605804,0.96191406,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8823242,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Nucleotide-sugar glycosyltransferase core,True,assigned_too_few_test_positives +11425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-proximal disordered linkers,False,no_term_above_threshold +11426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical GEF scaffold activation,False,no_term_above_threshold +11427,47529,25.055948,0.8979492,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8979492,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9938364569388666,0.3730434368700921,0.007089056269384138,,52.62243981348737,2.0,18.0,8.592160253638852,0.03740996961272103,Short domain-boundary docking motif,True,assigned_and_evaluated +11428,52940,16.153732,0.97753906,"AMP-binding, conserved site",interpro,36668,AMP-dependent synthetase/ligase domain,0.95410156,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,15.0,0.0,1.0,C-terminal ICA/S74 autoprotease modules,True,assigned_too_few_test_positives +11429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,G/S-rich disordered low-complexity,False,no_term_above_threshold +11430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal GH catalytic motif,False,no_term_above_threshold +11431,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature secreted protein domains,False,no_term_above_threshold +11432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic helix module,False,no_term_above_threshold +11433,52236,19.581333,0.9995117,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99609375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,15.0,208.41298377028713,5.90677576167075e-32,TPR helical register hotspots,True,assigned_too_few_test_positives +11434,37282,17.788998,0.9995117,Leucine-rich repeat,interpro,88009,Repeat,0.6401367,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,12.0,12.0,223.29962546816478,1.7581155688013136e-28,LRR coil-helix junctions,True,assigned_too_few_test_positives +11435,36535,17.440891,0.9609375,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.95166016,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9970627503337783,0.4394862155388471,0.004430660168365086,0.7,99.1920388471178,0.0,17.0,0.0,1.0,HATPase_c β-strand hotspot,True,assigned_and_evaluated +11436,37430,29.243465,0.9995117,"Signal transduction response regulator, receiver domain",interpro,37430,"Signal transduction response regulator, receiver domain",0.9995117,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,Phosphorelay transmitters and linkers,True,assigned_too_few_test_positives +11437,-1,,,,,-1,,,0,,,,,,,,,,,,,,,D/N-centered conserved motif,False,no_term_above_threshold +11438,25169,17.146208,0.8984375,pilus,go_cc,47529,Immunoglobulin-like fold,0.8613281,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9928952042628774,0.16164535379369138,0.002215330084182543,,72.9667127024723,0.0,17.0,0.0,1.0,Proline dipeptide turn motifs,True,assigned_and_evaluated +11439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization helices,False,no_term_above_threshold +11440,81858,15.8801985,0.88134766,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.71484375,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Catalytic/gating TM helix subsegments,True,assigned_too_few_test_positives +11441,47128,16.316984,0.84472656,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.84472656,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,0.0,20.0,0.0,1.0,Outer-membrane beta-barrel strands,True,assigned_too_few_test_positives +11442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-punctuated low-complexity IDRs,False,no_term_above_threshold +11443,52236,19.392893,0.99072266,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9819336,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,17.0,210.16435338180213,1.624802082425761e-36,Alpha-solenoid repeat boundaries,True,assigned_too_few_test_positives +11444,88161,85.58612,0.8901367,Transmembrane helix,keyword,88161,Transmembrane helix,0.8901367,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.9152760400375353,0.7508050817756364,0.1847585290208241,0.8992805755395683,4.063709998963097,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Hydrophobic membrane helices,True,assigned_and_evaluated +11445,88164,16.762074,0.75390625,Transposition,keyword,88163,Transposable element,0.69384766,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.6846358792184724,0.014426911148222624,0.002215330084182543,,6.512307692307693,1.0,17.0,42.76972740315638,0.038794528664871326,Recognition-linker spacer segment,True,assigned_and_evaluated +11446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site helical regions,False,no_term_above_threshold +11447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,YjeF_N NAD(P)HX repair fold,False,no_term_above_threshold +11448,63951,15.745338,0.96533203,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.95996094,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9873467773823645,0.47035384985982337,0.003987594151528578,0.6666666666666666,117.95429323706904,0.0,16.0,0.0,1.0,VIT domain signature,True,assigned_and_evaluated +11449,87882,39.01126,0.8935547,Palmitate,keyword,88058,Signal,0.6035156,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9990374648304456,0.7342592592592592,0.002658396101019052,1.0,276.2038580246913,19.0,20.0,63.284860335195525,1.7158666977028273e-33,Bacterial lipoprotein signal peptide,True,assigned_and_evaluated +11450,87326,32.97346,0.6772461,Coiled coil,keyword,87326,Coiled coil,0.6772461,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6656474149011153,0.29609943400830596,0.03943287549844927,0.2696629213483146,7.5089485680533326,16.0,16.0,12.607528018608585,5.942502901527074e-18,Extended coiled-coil scaffolds,True,assigned_and_evaluated +11451,36914,18.51504,0.84521484,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.81591797,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,8.0,16.0,368.0308641975309,2.6439420128383796e-19,UDP-sugar donor-gating loop,True,assigned_too_few_test_positives +11452,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regulatory tail activation,False,no_term_above_threshold +11453,59229,41.47879,0.97802734,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97802734,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8658090381845782,0.7393733719464295,0.0101905183872397,0.7391304347826086,72.55503045578658,15.0,15.0,106.27629233511585,1.2978692612531535e-30,Conserved methyltransferase SAM-binding loop,True,assigned_and_evaluated +11454,63960,20.638065,0.7050781,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.7050781,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,10.0,10.0,193.57467532467533,3.3236287975242214e-23,Oxidoreductase C-terminal helical tail,True,assigned_too_few_test_positives +11455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-P-loop helical clamp,False,no_term_above_threshold +11456,85649,30.11453,0.72509766,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7246094,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7691604063679888,0.09014143750295296,0.0101905183872397,,8.845618454094122,15.0,15.0,110.61410018552876,7.1622047874657735e-31,SAM-dependent RNA methyltransferase domain,True,assigned_and_evaluated +11457,46082,17.943653,0.9638672,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9638672,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9994920634920634,0.8676870748299319,0.0031014621178555605,1.0,279.7671039844509,16.0,16.0,150.93924050632913,5.241814974793697e-35,Membrane-proximal disordered regulatory linkers,True,assigned_and_evaluated +11458,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretin N-terminal periplasmic domains,False,no_term_above_threshold +11459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse replication-module activation,False,no_term_above_threshold +11460,37894,20.995226,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9995117,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR YXXXK-adjacent hydrophobic helix,True,assigned_too_few_test_positives +11461,47717,17.05788,0.97265625,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6323242,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,17.0,20.0,232.46720183486238,1.5910281491579475e-38,SF2 helicase C-terminal domain,True,assigned_too_few_test_positives +11462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hsp90 middle-domain KLLRY-ESS motif,False,no_term_above_threshold +11463,63831,20.31119,0.6777344,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.6777344,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.48978231896934693,0.002658396101019052,0.002658396101019052,,1.0,0.0,13.0,0.0,1.0,Basic glycine-rich polyanion-binding accessory modules,True,assigned_and_evaluated +11464,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solcar matrix-linker activation,False,no_term_above_threshold +11465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic juxtamembrane amphipathic helix,False,no_term_above_threshold +11466,88022,16.468597,0.7319336,Ribosomal protein,keyword,88022,Ribosomal protein,0.7319336,279,keywords,Ribosomal protein,keyword:keywords:Ribosomal protein,50.0,2257.0,0.8886859990937924,0.234510458110237,0.022153300841825433,0.28,10.585802079096098,3.0,14.0,19.29898575744497,0.0008056038319776139,uL5/RPL11 central helix motifs,True,assigned_and_evaluated +11467,85791,17.295849,0.93847656,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8544922,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,15.0,0.0,1.0,FAD-pocket β-strand/loop motif,True,assigned_too_few_test_positives +11468,85664,19.188278,0.98046875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98046875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Conserved C-terminal GT donor-pocket motif,True,assigned_too_few_test_positives +11469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LDLa and cysteine-rich ectodomains,False,no_term_above_threshold +11470,88058,21.833282,0.62890625,Signal,keyword,88058,Signal,0.62890625,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.623569842795132,0.10875552046172618,0.09127159946832078,,1.1915592703015339,7.0,20.0,2.5217341389728096,0.024798531661208274,Low-complexity disordered regions,True,assigned_and_evaluated +11471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small residue-rich low-complexity tracts,False,no_term_above_threshold +11472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long hydrophilic charged segments,False,no_term_above_threshold +11473,36091,18.05525,1.0,GNAT domain,interpro,85712,3.40.630.30,0.9975586,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,14.0,14.0,377.3481012658228,2.6485674118201105e-36,GNAT acetyl-CoA beta-sheet signature,True,assigned_too_few_test_positives +11474,25169,22.587513,0.89990234,pilus,go_cc,25169,pilus,0.89990234,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9955595026642984,0.22223919870978692,0.002215330084182543,,100.31877429759783,0.0,15.0,0.0,1.0,Extracellular β-sandwich strand hotspots,True,assigned_and_evaluated +11475,87697,17.857515,0.87402344,Knottin,keyword,88058,Signal,0.81396484,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9696770016878223,0.21446865759615164,0.017279574656623838,,12.411686158833698,0.0,20.0,0.0,1.0,Secreted protein C-terminus activation,True,assigned_and_evaluated +11476,8138,19.589024,0.6855469,translation,go_bp,8138,translation,0.6855469,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.7123580170819758,0.1499965125242204,0.018165706690296855,0.024390243902439025,8.257125091882083,1.0,14.0,7.367894216510133,0.20432986821030585,NusG/Spt5 NGN Spt4 interface,True,assigned_and_evaluated +11477,72011,17.95364,0.99072266,"AMP-binding enzyme, C-terminal domain superfamily",interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7739258,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,1.0,12.0,49.192244224422446,0.033930166355642694,SAM-binding methyltransferase core,True,assigned_too_few_test_positives +11478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global activation with N-terminal peak,False,no_term_above_threshold +11479,88161,22.739359,0.60498047,Transmembrane helix,keyword,88161,Transmembrane helix,0.60498047,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7108878114899386,0.5011438132147197,0.1847585290208241,0.44364508393285373,2.712425866728111,15.0,15.0,5.4274920345926265,2.044231257442523e-11,Transmembrane helix functional hotspots,True,assigned_and_evaluated +11480,85682,33.95811,0.81884766,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.81884766,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9729480286738351,0.5972371654964546,0.011076650420912717,0.52,53.91857130101992,19.0,19.0,102.26586620926243,3.3577842358066196e-38,Internal Rossmann NAD(P)-binding helix,True,assigned_and_evaluated +11481,87162,15.760192,0.64208984,Antimicrobial,keyword,88058,Signal,0.6152344,669,keywords,Antimicrobial,keyword:keywords:Antimicrobial,56.0,2257.0,0.7037507301875772,0.07701276001111795,0.024811696942844484,,3.103889274019522,3.0,18.0,8.984478601567208,0.007267364731515678,Post-signal membrane-active segments,True,assigned_and_evaluated +11482,52940,15.630934,0.9458008,"AMP-binding, conserved site",interpro,36499,"Zinc finger, GATA-type",0.89208984,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,11.0,0.0,1.0,ABC ATPase signature C-loop,True,assigned_too_few_test_positives +11483,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic anchors and linkers,False,no_term_above_threshold +11484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface beta-loop-beta interaction edge,False,no_term_above_threshold +11485,85672,24.194347,0.8286133,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.81591797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8392803541948072,0.21894620919053273,0.01595037660611431,0.1388888888888889,13.726710948417567,10.0,17.0,23.53770232925385,3.3472669082009384e-12,Noncatalytic helix-coil capping residues,True,assigned_and_evaluated +11486,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine protease catalytic cleft,False,no_term_above_threshold +11487,64507,30.73956,0.9995117,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9995117,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,19.0,19.0,165.15512465373962,5.007107605336941e-42,Ankyrin-repeat alanine register,True,assigned_and_evaluated +11488,87697,18.942324,0.83984375,Knottin,keyword,87413,Disulfide bond,0.7163086,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9892256826431758,0.4162541915952168,0.017279574656623838,0.9487179487179487,24.089377190523187,0.0,15.0,0.0,1.0,Disulfide-stabilized extracellular beta-strand repeats,True,assigned_and_evaluated +11489,85649,33.4958,0.77441406,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.77197266,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7577459032345958,0.3737555155968475,0.0101905183872397,0.43478260869565216,36.676791247916725,11.0,13.0,93.59654631083201,6.095396807171656e-21,Class I SAM-binding loop,True,assigned_and_evaluated +11490,37071,17.406086,0.78027344,Homeodomain,interpro,37071,Homeodomain,0.78027344,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,18.0,0.0,1.0,Acidic metal-binding catalytic helix,True,assigned_too_few_test_positives +11491,87413,17.285412,0.6088867,Disulfide bond,keyword,87413,Disulfide bond,0.6088867,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5743657738884469,0.08751892480001597,0.0717766947275144,,1.2193223041582473,2.0,18.0,1.3141352024510127,0.7113633164717458,Loop-to-beta transition signal,True,assigned_and_evaluated +11492,85364,16.269163,0.98095703,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.98095703,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,20.0,180.669696969697,4.776386852304328e-25,Hydrophobic core packing residues,True,assigned_too_few_test_positives +11493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enolase-superfamily C-terminal active-site loop,False,no_term_above_threshold +11494,87326,36.53625,0.68310547,Coiled coil,keyword,87326,Coiled coil,0.68310547,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6558055889547659,0.18369334152392003,0.03943287549844927,0.1348314606741573,4.658380582241433,16.0,20.0,10.08602241488687,1.9708165814388455e-14,Heptad-repeat coiled-coil scaffolds,True,assigned_and_evaluated +11495,85672,18.166819,0.6010742,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.6010742,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6209915453499425,0.17226905026085354,0.01595037660611431,0.16666666666666666,10.80031240107629,13.0,13.0,40.01409395973155,3.774017721320684e-21,SF2 helicase ATPase core,True,assigned_and_evaluated +11496,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich disordered regions,False,no_term_above_threshold +11497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site glycine loop-helix,False,no_term_above_threshold +11498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature exported catalytic domains,False,no_term_above_threshold +11499,55053,23.435078,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,12.0,12.0,552.0462962962963,3.0471251534694055e-33,NRPS Condensation catalytic motif,True,assigned_too_few_test_positives +11500,88161,81.60532,0.8383789,Transmembrane helix,keyword,88161,Transmembrane helix,0.8383789,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8663212907934522,0.7278297646412841,0.1847585290208241,0.8009592326139089,3.9393567836819625,13.0,13.0,5.4274920345926265,5.833912717653736e-10,Hydrophobic TM helix core,True,assigned_and_evaluated +11501,85672,15.619793,0.6855469,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.67529297,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7372117164440442,0.04549848348213178,0.01595037660611431,,2.852502144976984,0.0,16.0,0.0,1.0,N-terminal helix-start ATP-binding patch,True,assigned_and_evaluated +11502,36091,27.326797,0.9995117,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,17.0,17.0,377.3481012658228,1.0362764569171756e-43,GNAT active-site beta strand,True,assigned_too_few_test_positives +11503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface amphipathic alpha-helices,False,no_term_above_threshold +11504,88058,29.461906,0.6821289,Signal,keyword,88058,Signal,0.6821289,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.677034172295778,0.13058408882083067,0.09127159946832078,,1.4307198469350233,0.0,19.0,0.0,1.0,Initiator methionine at M1,True,assigned_and_evaluated +11505,64003,25.194532,0.98339844,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.98095703,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,11.0,11.0,130.4617067833698,1.3724628209314255e-23,C2H2 inter-finger linker peaks,True,assigned_and_evaluated +11506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal histone-fold modules,False,no_term_above_threshold +11507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured domain core activation,False,no_term_above_threshold +11508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic macromolecule-binding scaffolds,False,no_term_above_threshold +11509,39971,20.494764,0.83154297,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.8251953,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,15.0,0.0,1.0,Metallohydrolase N-terminal rim segment,True,assigned_too_few_test_positives +11510,85712,15.7086115,0.9863281,3.40.630.30,gene3d,85712,3.40.630.30,0.9863281,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,13.0,16.0,230.67648809523808,1.798862684010233e-29,Pocket lining beta strands,True,assigned_too_few_test_positives +11511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding helix-loop motifs,False,no_term_above_threshold +11512,36115,17.118576,0.76904297,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.75683594,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,17.0,0.0,1.0,T9SS CTD and beta-turns,True,assigned_too_few_test_positives +11513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-linked GT-C glycosyltransferases,False,no_term_above_threshold +11514,36914,20.094307,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.94628906,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Glycosyltransferase active-site beta-strand,True,assigned_too_few_test_positives +11515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic-rich low-complexity IDRs,False,no_term_above_threshold +11516,36876,15.705455,1.0,Cytochrome P450,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8496094,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,15.0,15.0,389.6797385620915,5.164997713117673e-39,P450 E–F–G roof,True,assigned_and_evaluated +11517,37314,17.118132,0.9975586,"Helicase, C-terminal domain-like",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6386719,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,14.0,14.0,317.1329787234043,3.0968442738517224e-35,Hel2 motif V-VI coupling,True,assigned_too_few_test_positives +11518,47717,17.035141,0.9511719,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.62890625,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,15.0,255.25810397553516,3.4181598419221845e-33,SF2 helicase ATPase core,True,assigned_too_few_test_positives +11519,52941,24.313723,0.99853516,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9863281,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,19.0,19.0,260.353711790393,1.5255431321768337e-45,Positive-inside helix-end anchors,True,assigned_too_few_test_positives +11520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet loop hotspots,False,no_term_above_threshold +11521,47529,17.79631,0.71240234,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.71240234,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8257892681838465,0.16489436309518454,0.007089056269384138,0.0625,23.26041109411447,0.0,14.0,0.0,1.0,Soluble-domain functional surfaces,True,assigned_and_evaluated +11522,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine-rich beta-strand coil motif,False,no_term_above_threshold +11523,45288,16.792109,0.98339844,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.98339844,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,13.0,13.0,462.17829457364337,6.281107742864664e-35,REC beta5-alpha5 output face,True,assigned_too_few_test_positives +11524,81858,15.978704,0.8911133,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6948242,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,13.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +11525,38317,16.909807,0.7290039,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7290039,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6252063492063492,0.009564210760449481,0.0031014621178555605,,3.083774812333497,0.0,10.0,0.0,1.0,Transporter TM2–TM3 hairpin,True,assigned_and_evaluated +11526,87384,17.464209,0.6513672,DNA-binding,keyword,87384,DNA-binding,0.6513672,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.5444786137557222,0.04392968089018806,0.043863535666814356,,1.0015079774662066,2.0,20.0,1.2250051366344772,0.7675321987297693,Glycine amidation motif detector,True,assigned_and_evaluated +11527,39971,19.51642,0.9902344,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.95703125,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,PAC beta-strand Asp hotspot,True,assigned_too_few_test_positives +11528,36010,18.637812,0.9736328,Alpha/beta hydrolase fold-1,interpro,85388,Glutaredoxin,0.94091797,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,16.0,0.0,1.0,Trx-fold post-CXXC helix,True,assigned_too_few_test_positives +11529,84152,24.711374,0.9975586,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9975586,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,18.0,18.0,562.4622641509434,5.407112538669923e-49,Active site scaffold helices,True,assigned_too_few_test_positives +11530,82597,38.721584,0.9765625,Tetratricopeptide repeat domain,gene3d,82597,Tetratricopeptide repeat domain,0.9765625,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9962978198272315,0.6138122403911876,0.0057598582188746125,0.5384615384615384,106.56724819714695,19.0,19.0,97.41993464052287,8.24821872222538e-38,TPR boundary coil turns,True,assigned_and_evaluated +11531,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane prenyl/lipid-binding core,False,no_term_above_threshold +11532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-sequence strand–turn–strand,False,no_term_above_threshold +11533,46277,30.19378,0.9902344,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9902344,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9972476321541326,0.5043145052714431,0.004873726185201595,1.0,103.47616712705883,5.0,18.0,52.244128987031196,6.615990709495391e-08,Small beta-barrel strand detector,True,assigned_and_evaluated +11534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclic nucleotide-sensing domains,False,no_term_above_threshold +11535,49236,17.719118,0.8540039,C-type lectin fold,interpro,49236,C-type lectin fold,0.8540039,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.6946269982238009,0.10847205519336667,0.002215330084182543,,48.964285714285715,0.0,20.0,0.0,1.0,Gram-positive cell wall binding modules,True,assigned_and_evaluated +11536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal core-engaging module,False,no_term_above_threshold +11537,45317,17.213398,0.8774414,"Six-bladed beta-propeller, TolB-like",interpro,45317,"Six-bladed beta-propeller, TolB-like",0.8774414,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,7.0,18.0,297.255698005698,3.7433154085055503e-16,S9 serine peptidase loop/linker signature,True,assigned_too_few_test_positives +11538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic C-terminal PPI helices,False,no_term_above_threshold +11539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal domain-surface segments,False,no_term_above_threshold +11540,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-centered sensory hinge motif,False,no_term_above_threshold +11541,37071,16.637896,0.82958984,Homeodomain,interpro,80926,Homeodomain-like,0.70458984,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,12.0,0.0,1.0,Transcription factor C-terminal IDRs,True,assigned_too_few_test_positives +11542,63774,16.931751,0.9819336,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.9819336,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,7.0,15.0,85.34703476482618,1.8711351254267013e-12,RRM beta-sheet hydrophobic anchors,True,assigned_too_few_test_positives +11543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDR low-complexity boundary detector,False,no_term_above_threshold +11544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic transmembrane alpha-helices,False,no_term_above_threshold +11545,38873,15.58676,0.9760742,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9482422,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9957371225577264,0.33904761904761904,0.002215330084182543,0.2,153.04609523809523,12.0,17.0,120.93509127789048,2.2316418537937037e-23,Walker B DE motif,True,assigned_and_evaluated +11546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory inserts and appendages,False,no_term_above_threshold +11547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic amphipathic beta-strand motif,False,no_term_above_threshold +11548,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal amphipathic helices,False,no_term_above_threshold +11549,55054,22.358013,0.8286133,HAD superfamily,interpro,55054,HAD superfamily,0.8286133,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.7988454706927176,0.600886132033673,0.002215330084182543,0.6,271.24,1.0,11.0,30.44994892747702,0.053759342247007035,βα motif near phosphate pocket,True,assigned_and_evaluated +11550,36535,17.24168,0.94970703,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.9326172,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9476858032932798,0.9004430660168364,0.004430660168365086,0.9,203.23,13.0,13.0,89.79066265060241,1.1174852366600676e-25,Kinase C-lobe helix-loop junction,True,assigned_and_evaluated +11551,37430,16.418653,0.921875,"Signal transduction response regulator, receiver domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.75146484,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,0.0,10.0,0.0,1.0,ABC ATPase H-loop/switch,True,assigned_too_few_test_positives +11552,49045,20.298426,0.9472656,Kelch-type beta propeller,interpro,49045,Kelch-type beta propeller,0.9472656,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,16.0,0.0,1.0,RCC1-like propeller blade tips,True,assigned_too_few_test_positives +11553,36010,17.053684,0.953125,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.91015625,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,9.0,16.0,286.6394230769231,9.458468972978633e-21,Hydrolase N-terminal cap/signal peptide,True,assigned_too_few_test_positives +11554,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid binding and assembly tracks,False,no_term_above_threshold +11555,64058,29.738876,0.9272461,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9067383,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9925800904400993,0.5617367926471966,0.006202924235711121,0.5714285714285714,90.55999578605162,0.0,15.0,0.0,1.0,Phosphate-binding N-cap helix,True,assigned_and_evaluated +11556,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet rim loops,False,no_term_above_threshold +11557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand boundary capping residues,False,no_term_above_threshold +11558,64148,18.682327,0.84716797,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7939453,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.7744579276609755,0.03356787101308987,0.008418254319893664,,3.9875097303444127,0.0,20.0,0.0,1.0,Helix C-cap loop motifs,True,assigned_and_evaluated +11559,64058,16.328293,0.84521484,NAD(P)-binding domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7260742,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9545411120310807,0.08046053534962751,0.006202924235711121,,12.971387734579235,0.0,20.0,0.0,1.0,Amphipathic helical interface hotspots,True,assigned_and_evaluated +11560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity linkers,False,no_term_above_threshold +11561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop boundary signature,False,no_term_above_threshold +11562,85672,19.253462,0.74072266,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73828125,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7418642753514432,0.04718019158371686,0.01595037660611431,,2.9579359001235823,2.0,15.0,5.335212527964206,0.08698176689532991,Internal hydrophobic/aromatic micro-motifs,True,assigned_and_evaluated +11563,42054,16.57814,0.99902344,Radical SAM,interpro,42054,Radical SAM,0.99902344,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,13.0,15.0,587.1765151515152,3.430579151480721e-35,Radical SAM C-terminal accessory helix,True,assigned_too_few_test_positives +11564,36914,16.579903,0.82373047,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7114258,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,10.0,15.0,490.7078189300411,1.114942661660452e-25,Nucleotide-sugar glycosyltransferase core,True,assigned_too_few_test_positives +11565,59224,20.321138,0.95996094,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8574219,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9853968253968254,0.13977697766849456,0.0031014621178555605,,45.06809122825603,0.0,16.0,0.0,1.0,Helices flanking cofactor-binding pockets,True,assigned_and_evaluated +11566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix–loop interface module,False,no_term_above_threshold +11567,46929,17.332706,0.8486328,"Zinc finger, RING/FYVE/PHD-type",interpro,88261,Zinc,0.77001953,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.7576376554174069,0.02677639444963485,0.002215330084182543,,12.086864454565172,2.0,18.0,9.545469100224143,0.03087493598853573,Extended helical and transmembrane scaffolds,True,assigned_and_evaluated +11568,59229,20.590336,0.9326172,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9326172,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9605017321240902,0.46216472244578527,0.0101905183872397,0.30434782608695654,45.35242515478858,1.0,16.0,6.642268270944741,0.22367543091129083,Helical hydrophobic core packing,True,assigned_and_evaluated +11569,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PP2C/PPM loop-beta submotif,False,no_term_above_threshold +11570,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane proximal envelope linkers,False,no_term_above_threshold +11571,37894,17.107086,0.7265625,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7265625,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,18.0,0.0,1.0,Soluble extramembrane regions,True,assigned_too_few_test_positives +11572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-gating transmembrane helices,False,no_term_above_threshold +11573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active-site substructure,False,no_term_above_threshold +11574,64507,26.070755,0.8979492,Ankyrin repeat-containing domain superfamily,interpro,82597,Tetratricopeptide repeat domain,0.85498047,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9805753262158956,0.13000079666540482,0.003987594151528578,,32.60131089709097,0.0,18.0,0.0,1.0,Membrane-tethering amphipathic coiled-coils,True,assigned_and_evaluated +11575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich beta-edge loops,False,no_term_above_threshold +11576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long C-terminal appendages,False,no_term_above_threshold +11577,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-ligand catalytic core scaffold,False,no_term_above_threshold +11578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly interface segments,False,no_term_above_threshold +11579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed low-complexity surfaces,False,no_term_above_threshold +11580,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic scaffold C-terminal tails,False,no_term_above_threshold +11581,32555,18.331387,0.81396484,"proton-transporting ATP synthase activity, rotational mechanism",go_mf,87109,ATP synthesis,0.74072266,70,go,GO:0046933,go_mf:go:GO:0046933,23.0,2257.0,0.9758281110116384,0.6773709071004244,0.0101905183872397,0.9565217391304348,66.47070162285468,0.0,14.0,0.0,1.0,Amphipathic coiled-coil helices,True,assigned_and_evaluated +11582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Viral maturation protease, disulfide cysteines",False,no_term_above_threshold +11583,81799,16.586998,0.9790039,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6635742,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,10.0,10.0,578.8446601941747,5.132121727340274e-28,AAA+ lid/neck linker helix,True,assigned_too_few_test_positives +11584,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity cytosolic juxtamembrane tails,False,no_term_above_threshold +11585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topoisomerase II transducer motif,False,no_term_above_threshold +11586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal GATase interface core,False,no_term_above_threshold +11587,58239,25.718454,0.63378906,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63378906,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6727334235453316,0.2803653544953438,0.017722640673460344,0.35,15.819615127399773,10.0,10.0,35.851473241130485,6.616398228015838e-16,P-loop NTPase catalytic core,True,assigned_and_evaluated +11588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic scaffolds,False,no_term_above_threshold +11589,87601,21.36686,0.6503906,Hydrolase,keyword,87601,Hydrolase,0.6503906,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6165106847605678,0.09093366872712294,0.05316792202038104,,1.7103107526426373,1.0,12.0,0.9319858688176076,1.0,Catalytic beta-alpha/N-cap loops,True,assigned_and_evaluated +11590,48255,21.45851,0.79345703,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.79345703,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,11.0,16.0,234.22535714285715,1.3023373443007147e-24,Phosphate-binding beta–alpha loop,True,assigned_too_few_test_positives +11591,45290,25.505789,0.96728516,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.96728516,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9582819141642671,0.8978789634527337,0.0057598582188746125,0.9230769230769231,155.88560157790923,16.0,16.0,73.42487684729065,4.583656533651311e-30,Protein kinase alpha C helix,True,assigned_and_evaluated +11592,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-loop capping coordinators,False,no_term_above_threshold +11593,87697,23.359758,0.8876953,Knottin,keyword,88058,Signal,0.66064453,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9662782363413562,0.19449846780690563,0.017279574656623838,,11.25597543179964,0.0,16.0,0.0,1.0,Metal-binding beta-edge hairpins,True,assigned_and_evaluated +11594,38317,25.91008,1.0,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7792969,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,11.0,11.0,384.6516129032258,8.972063948750959e-29,PPR/TPR repeat boundary detector,True,assigned_and_evaluated +11595,36104,21.704803,0.9584961,Rho GTPase-activating protein domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6098633,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,NTPase switch/lid coupling region,True,assigned_too_few_test_positives +11596,45553,16.210678,0.9692383,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.9326172,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,2.0,17.0,80.62339418526031,0.0005067489527351329,Conserved catalytic scaffold helix,True,assigned_too_few_test_positives +11597,81685,22.784956,0.9667969,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9472656,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9571455085374906,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,17.0,17.0,85.66235632183908,5.1673760881485446e-33,Protein kinase activation loop,True,assigned_and_evaluated +11598,64620,18.079472,0.9667969,Histidine kinase/HSP90-like ATPase superfamily,interpro,85712,3.40.630.30,0.8886719,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,20.0,20.0,324.0271739130435,1.8873655770401856e-49,GHKL ATP-lid glycine loop,True,assigned_too_few_test_positives +11599,50869,24.339338,0.99902344,"DNA binding HTH domain, AraC-type",interpro,88263,Zinc-finger,0.79003906,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,14.0,0.0,1.0,C2H2 DNA recognition helix,True,assigned_too_few_test_positives +11600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible charged C-terminal tails,False,no_term_above_threshold +11601,85672,22.665867,0.63378906,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6323242,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6210540797438592,0.1407546695798062,0.01595037660611431,0.16666666666666666,8.824535812267294,10.0,13.0,30.780072276716574,5.6325263107026746e-14,Sensor-2 arginine-finger switch helix,True,assigned_and_evaluated +11602,82029,26.512817,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,MFS transmembrane functional hotspots,True,assigned_too_few_test_positives +11603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity detector,False,no_term_above_threshold +11604,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regional activation patches,False,no_term_above_threshold +11605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal partner-binding modules,False,no_term_above_threshold +11606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity tails,False,no_term_above_threshold +11607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature catalytic enzyme cores,False,no_term_above_threshold +11608,49236,21.35923,0.9057617,C-type lectin fold,interpro,49236,C-type lectin fold,0.9057617,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,1.0,15.0,36.13393939393939,0.045616660485468793,Disulfide-stabilized extracellular recognition modules,True,assigned_and_evaluated +11609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand core recognition,False,no_term_above_threshold +11610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity sensory regions,False,no_term_above_threshold +11611,45324,17.332352,0.9736328,Pectin lyase fold/virulence factor,interpro,85712,3.40.630.30,0.90185547,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9801065719360569,0.05927567770097388,0.002215330084182543,,26.757040914219612,16.0,16.0,546.9816513761467,8.086221761424609e-44,Beta-helix strand N-cap signal,True,assigned_and_evaluated +11612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-nucleation/hinge segments,False,no_term_above_threshold +11613,87149,24.195799,0.74609375,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.74609375,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.843683906940973,0.20714765303189334,0.012405848471422242,,16.697580460463687,0.0,20.0,0.0,1.0,Mature secreted peptide cores,True,assigned_and_evaluated +11614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HINT/intein autoprocessing domains,False,no_term_above_threshold +11615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-catalytic RT/RdRp fingers/palm,False,no_term_above_threshold +11616,37071,16.776815,0.9584961,Homeodomain,interpro,87384,DNA-binding,0.6640625,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,11.0,0.0,1.0,Eukaryotic TF DNA-binding cores,True,assigned_too_few_test_positives +11617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular charged repeat scaffolds,False,no_term_above_threshold +11618,87857,17.99427,0.6230469,Nucleus,keyword,87857,Nucleus,0.6230469,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6127310997600183,0.11288746653929728,0.06247230837394772,0.014184397163120567,1.8070000849588224,13.0,17.0,4.633387135341941,1.6176219961476968e-07,Phospho-regulated low-complexity IDRs,True,assigned_and_evaluated +11619,48883,19.63425,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,13.0,13.0,480.8145161290322,3.7255170365673266e-35,C-terminal PLP active-site cap,True,assigned_too_few_test_positives +11620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GST C-terminal H-site bundle,False,no_term_above_threshold +11621,37894,22.10146,0.9140625,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.79248047,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,NAD(P)H oxidoreductase C-terminal lid loop,True,assigned_too_few_test_positives +11622,63951,20.29543,0.94677734,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9399414,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9945630684064848,0.26757000367737566,0.003987594151528578,,67.1006109222041,0.0,18.0,0.0,1.0,Proline-rich glycosylation-prone loops,True,assigned_and_evaluated +11623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTPase catalytic loop hotspots,False,no_term_above_threshold +11624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta-strands,False,no_term_above_threshold +11625,36104,17.643034,0.99902344,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99902344,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Peptidoglycan catalytic helix-loop,True,assigned_too_few_test_positives +11626,59218,15.759814,0.71240234,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.71240234,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,0.0,10.0,0.0,1.0,CE4/NodB catalytic loop motif,True,assigned_too_few_test_positives +11627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic heme/copper redox domains,False,no_term_above_threshold +11628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Charged disorder, catalytic motifs",False,no_term_above_threshold +11629,64168,17.234503,0.78125,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.78125,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.7930728241563056,0.19612422727176826,0.002215330084182543,0.4,88.5304761904762,0.0,11.0,0.0,1.0,Charged C-terminal enzyme segments,True,assigned_and_evaluated +11630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane anchors,False,no_term_above_threshold +11631,82029,21.34825,0.9848633,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.74658203,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,4.0,15.0,50.15436382754994,1.964335637020634e-06,Multi-pass transmembrane helix signal,True,assigned_too_few_test_positives +11632,64026,15.795973,0.7963867,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.6147461,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.865430179179624,0.029669210656573814,0.002658396101019052,,11.160568075314515,0.0,17.0,0.0,1.0,Membrane-interface helix caps,True,assigned_and_evaluated +11633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Assembly scaffold interaction modules,False,no_term_above_threshold +11634,45553,22.840609,0.9765625,Restriction endonuclease type II-like,interpro,45553,Restriction endonuclease type II-like,0.9765625,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,4.0,17.0,161.24678837052062,1.9919493236924667e-08,Nuclease catalytic core signature,True,assigned_too_few_test_positives +11635,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface attachment fiber modules,False,no_term_above_threshold +11636,58239,28.613573,0.6582031,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6582031,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.631309201623816,0.18280439645114996,0.017722640673460344,0.225,10.314738069756137,17.0,17.0,35.851473241130485,1.1097904818074523e-26,Kinase phosphate-lid helix,True,assigned_and_evaluated +11637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-wall enzyme catalytic core,False,no_term_above_threshold +11638,36951,16.578918,0.93310547,SET domain,interpro,87409,Dioxygenase,0.85839844,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,14.0,0.0,1.0,Fe/2OG oxygenase active site,True,assigned_too_few_test_positives +11639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL and S1 phosphate caps,False,no_term_above_threshold +11640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-PDZ strand-helix linker,False,no_term_above_threshold +11641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar acidic low-complexity tracts,False,no_term_above_threshold +11642,69819,18.250692,0.9243164,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.9111328,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,ASKHA C-terminal helix hotspot,True,assigned_too_few_test_positives +11643,87149,18.985012,0.7265625,Amphibian defense peptide,keyword,87760,Membrane,0.6489258,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.707219765429725,0.03636473472135088,0.012405848471422242,,2.931257366646033,0.0,19.0,0.0,1.0,Aromatic/cysteine interfacial anchors,True,assigned_and_evaluated +11644,49230,31.08297,0.8852539,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.8852539,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,9.0,14.0,180.79144204851752,3.834220323902381e-19,Acyltransferase cofactor binding region,True,assigned_too_few_test_positives +11645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HK97-like capsid oligomerization regions,False,no_term_above_threshold +11646,69990,15.847919,0.92089844,DNA/RNA polymerase superfamily,interpro,69990,DNA/RNA polymerase superfamily,0.92089844,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.7779047619047619,0.2673155926083326,0.0031014621178555605,0.42857142857142855,86.19018464528666,13.0,13.0,262.647577092511,1.0427198703452427e-31,Polymerase palm pre-catalytic helix,True,assigned_and_evaluated +11647,37020,16.921017,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,18.0,771.3523592085236,3.565291332168778e-48,Glycosyltransferase glycine-rich donor loop,True,assigned_too_few_test_positives +11648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +11649,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal substrate-gating segment,False,no_term_above_threshold +11650,66234,17.082912,0.87109375,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.87109375,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,1.0,16.0,14.786954365079364,0.10716723326986072,Trp/Tyr-rich precatalytic loop,True,assigned_too_few_test_positives +11651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-Pro-rich acidic IDRs,False,no_term_above_threshold +11652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent cyclase/hydrolase cores,False,no_term_above_threshold +11653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TRM9/ALKBH8 RYYHVF arginine hotspot,False,no_term_above_threshold +11654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal-peptide mature N-terminus,False,no_term_above_threshold +11655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate/Nucleotide Transfer Enzymes,False,no_term_above_threshold +11656,36914,22.666227,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,14.0,18.0,572.4924554183814,4.208106336650563e-37,xxYP-like glycosyltransferase motif,True,assigned_too_few_test_positives +11657,81858,18.513136,0.8071289,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8071289,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,18.0,18.0,261.4956140350877,2.4311406675922474e-43,Disordered cytoplasmic regulatory tails,True,assigned_too_few_test_positives +11658,85656,19.585464,0.66748047,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.66503906,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.926952380952381,0.5600802542254532,0.0031014621178555605,0.7142857142857143,180.58587625526397,15.0,15.0,141.281990521327,1.9050930748244927e-32,N-terminal amphipathic lid helix,True,assigned_and_evaluated +11659,38317,17.501009,0.84716797,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.84716797,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9175873015873016,0.01977046974821988,0.0031014621178555605,,6.374564317390324,0.0,15.0,0.0,1.0,Histidine kinase DHp helix,True,assigned_and_evaluated +11660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic helical patches,False,no_term_above_threshold +11661,64058,17.790012,0.87597656,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.87060547,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9773103623972995,0.1592867769157618,0.006202924235711121,0.07142857142857142,25.67930396420531,0.0,17.0,0.0,1.0,Glycine-rich anion-binding loops,True,assigned_and_evaluated +11662,64026,20.505507,0.95410156,MFS transporter superfamily,interpro,88161,Transmembrane helix,0.8173828,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9520953650229527,0.033375768301007004,0.002658396101019052,,12.5548515092288,1.0,15.0,11.29185606060606,0.13823380023093623,Transmembrane helical bundle packing,True,assigned_and_evaluated +11663,85762,29.96611,0.92822266,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.92041016,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,15.0,15.0,205.58965517241379,7.110790058883305e-35,Flavoenzyme catalytic-loop signature,True,assigned_too_few_test_positives +11664,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB box motif activation,False,no_term_above_threshold +11665,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/localization segments,False,no_term_above_threshold +11666,48767,16.90679,0.87402344,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.87402344,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,17.0,0.0,1.0,Acidic C-terminal active-site neighborhoods,True,assigned_too_few_test_positives +11667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-protein functional core,False,no_term_above_threshold +11668,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured beta-surface interaction patches,False,no_term_above_threshold +11669,46929,19.742966,0.93652344,"Zinc finger, RING/FYVE/PHD-type",interpro,87413,Disulfide bond,0.80859375,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9649644760213145,0.03636880388258221,0.002215330084182543,,16.41687807259761,0.0,16.0,0.0,1.0,Disordered N-terminal regulatory motifs,True,assigned_and_evaluated +11670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global secondary structure activation,False,no_term_above_threshold +11671,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ribosome biogenesis structured cores,False,no_term_above_threshold +11672,86130,16.137794,0.88134766,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.8808594,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9256190476190477,0.8371777598943875,0.0031014621178555605,0.8571428571428571,269.93002915451893,18.0,19.0,227.75424448217314,1.4801340031053627e-41,Gal4-type C-terminal activation,True,assigned_and_evaluated +11673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic segments and catalytic cores,False,no_term_above_threshold +11674,36977,15.921144,0.9628906,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.84375,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase DHp coiled-coil,True,assigned_too_few_test_positives +11675,58239,21.537334,0.60302734,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.60302734,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6072733423545331,0.07938014067509044,0.017722640673460344,,4.4790244375919785,7.0,12.0,20.91335939065945,1.8254996024967553e-08,SF1/SF2 helicase ATPase core,True,assigned_and_evaluated +11676,87857,24.610594,0.6972656,Nucleus,keyword,24917,nucleus,0.69433594,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7740601831369236,0.1906281560265931,0.06247230837394772,,3.051402469163267,3.0,20.0,0.9088567073170731,1.0,Disordered Ser/Thr phosphorylation sites,True,assigned_and_evaluated +11677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SF1/SF2 helicase ATPase loops,False,no_term_above_threshold +11678,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PNP-family catalytic domain,False,no_term_above_threshold +11679,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity regulatory IDRs,False,no_term_above_threshold +11680,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"DNA-recognition helices, phosphate-binding motifs",False,no_term_above_threshold +11681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CheB interdomain linker microenvironment,False,no_term_above_threshold +11682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed aromatic binding loops,False,no_term_above_threshold +11683,37894,18.815578,0.9995117,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8300781,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR pre-Tyr-helix catalytic loop,True,assigned_too_few_test_positives +11684,86130,23.476263,0.83154297,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,86130,Zn(2)-C6 fungal-type DNA-binding domain,0.83154297,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.7645079365079365,0.026466611261784928,0.0031014621178555605,,8.533591659692654,0.0,12.0,0.0,1.0,Basic N-terminal nucleic-acid segments,True,assigned_and_evaluated +11685,37341,26.54911,0.9995117,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9819336,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 blade N-cap motif,True,assigned_and_evaluated +11686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding-surface rim patch,False,no_term_above_threshold +11687,49236,17.398754,0.99902344,C-type lectin fold,interpro,49236,C-type lectin fold,0.99902344,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,6.0,17.0,191.29732620320857,9.252841120234038e-13,CTLD/SCP helix-coil micro-patch,True,assigned_and_evaluated +11688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain entry motifs,False,no_term_above_threshold +11689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping motifs,False,no_term_above_threshold +11690,52236,21.16484,0.9824219,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.96777344,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,18.0,186.08302122347067,1.3855153806489415e-32,Helix–coil boundary linkers,True,assigned_too_few_test_positives +11691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral mixed-charge interface segment,False,no_term_above_threshold +11692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease TM helices,False,no_term_above_threshold +11693,87108,18.530842,0.9003906,ANK repeat,keyword,87413,Disulfide bond,0.8881836,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8768040727560301,0.016666983248831833,0.003987594151528578,,4.179709021401495,0.0,19.0,0.0,1.0,Disulfide-rich ectodomain repeats,True,assigned_and_evaluated +11694,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted catalytic motif plus linkers,False,no_term_above_threshold +11695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved NTPase coupling domains,False,no_term_above_threshold +11696,38317,17.783098,0.97802734,Pentatricopeptide repeat,interpro,88009,Repeat,0.6933594,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9806349206349206,0.2855228202392068,0.0031014621178555605,0.14285714285714285,92.06071503998425,2.0,13.0,59.1771712158809,0.0009128347695835454,Tandem repeat binding scaffolds,True,assigned_and_evaluated +11697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant TNL/ANK immune activator,False,no_term_above_threshold +11698,35372,15.617311,0.9160156,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9160156,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,16.0,19.0,590.6724458204334,8.290426350539573e-43,ABC type-2 TM helix,True,assigned_too_few_test_positives +11699,87277,22.150364,0.88623047,Cell outer membrane,keyword,88058,Signal,0.78759766,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.8393650793650794,0.0860624998781081,0.0031014621178555605,,27.749008889269998,13.0,20.0,95.21781326781328,1.2414545626337994e-23,Gram-negative Sec signal peptide,True,assigned_and_evaluated +11700,45804,18.418919,0.95166016,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.9394531,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,17.0,0.0,1.0,Helical small-residue glycosyltransferase hinge,True,assigned_too_few_test_positives +11701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal metal-binding scaffold,False,no_term_above_threshold +11702,85656,28.184013,0.7084961,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.7084961,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8554285714285715,0.5461242272717682,0.0031014621178555605,0.42857142857142855,176.0860544217687,18.0,18.0,141.281990521327,9.999057839062593e-39,Hydrolase active-site capping loops,True,assigned_and_evaluated +11703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phe-rich low-complexity IDRs,False,no_term_above_threshold +11704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal disordered region detector,False,no_term_above_threshold +11705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic helical linkers,False,no_term_above_threshold +11706,87276,37.802517,0.6743164,Cell membrane,keyword,88161,Transmembrane helix,0.6660156,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.774929196474322,0.5444214055958395,0.11120957022596367,0.5896414342629482,4.895454631194461,16.0,19.0,6.9098758456835725,3.4349742150003185e-12,Extracellular interhelical redox loops,True,assigned_and_evaluated +11707,36876,16.626083,0.9980469,Cytochrome P450,interpro,39958,Basic-leucine zipper domain,0.9291992,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,17.0,389.6797385620915,6.157114732498076e-44,P450 heme-thiolate motif,True,assigned_and_evaluated +11708,36091,24.635965,0.9892578,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9760742,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,Acyltransferase N-terminal helix,True,assigned_too_few_test_positives +11709,36272,16.717918,0.9555664,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.9555664,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,17.0,0.0,1.0,Alpha-helical tracts and caps,True,assigned_too_few_test_positives +11710,85364,27.930538,0.96533203,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.96533203,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,18.0,284.3874859708193,6.285282157931668e-41,VFT LBD coupling patch,True,assigned_too_few_test_positives +11711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core residues,False,no_term_above_threshold +11712,82608,31.700743,0.9921875,Ankyrin repeat-containing domain,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.98876953,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.9988883948421521,0.6826704545454546,0.003544528134692069,1.0,192.5984019886364,11.0,11.0,170.34571428571428,7.327299794477209e-25,Ankyrin/ARM repeat PPI scaffold,True,assigned_and_evaluated +11713,81685,22.6198,0.9770508,Transferase(Phosphotransferase) domain 1,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.9770508,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9557720861172976,0.9171097326835032,0.005316792202038104,0.9166666666666666,172.49305555555554,12.0,12.0,85.66235632183908,1.67612287920582e-23,Kinase C-lobe alphaF N-cap,True,assigned_and_evaluated +11714,87326,38.36723,0.73876953,Coiled coil,keyword,87326,Coiled coil,0.73876953,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7761127119698163,0.26934157743214193,0.03943287549844927,0.20224719101123595,6.830381351284768,12.0,20.0,7.564516811165151,8.54613056014215e-09,Coiled-coil heptad-register detector,True,assigned_and_evaluated +11715,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TonB-dependent receptor gating module,False,no_term_above_threshold +11716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic flanking interface helices,False,no_term_above_threshold +11717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal phospho-regulated IDR scaffolds,False,no_term_above_threshold +11718,64016,50.078255,0.95654297,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.95654297,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9995555555555555,0.8444444444444444,0.0031014621178555605,1.0,272.2730158730159,10.0,10.0,221.63940520446096,8.628605611931638e-24,Thioredoxin-fold redox modules,True,assigned_and_evaluated +11719,59224,24.904318,0.9692383,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.91503906,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9989206349206349,0.7036546786546787,0.0031014621178555605,1.0,226.87837281765854,19.0,19.0,137.37557603686636,1.4828928465544412e-40,AB-hydrolase post-elbow helix,True,assigned_and_evaluated +11720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal structured assembly subdomain,False,no_term_above_threshold +11721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ambiguous/noncanonical residue detector,False,no_term_above_threshold +11722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAL-domain c-di-GMP PDE signature,False,no_term_above_threshold +11723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended noncatalytic scaffold regions,False,no_term_above_threshold +11724,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended basic interaction lobes,False,no_term_above_threshold +11725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix boundaries,False,no_term_above_threshold +11726,38654,15.939723,0.8105469,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.8105469,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,19.0,0.0,1.0,Nuclease catalytic cores,True,assigned_too_few_test_positives +11727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FMN-binding PW-aromatic motif,False,no_term_above_threshold +11728,85664,16.02645,0.9663086,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.94677734,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,16.0,0.0,1.0,INAT loop and substrate Tyr,True,assigned_too_few_test_positives +11729,37468,27.920662,0.9951172,"Zinc finger, RING-type",interpro,88263,Zinc-finger,0.76171875,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,20.0,20.0,137.37557603686636,1.3818410501239142e-42,Pre-RING N-terminal flanking segment,True,assigned_too_few_test_positives +11730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic coiled-coil stalks,False,no_term_above_threshold +11731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic PG-binding and redox,False,no_term_above_threshold +11732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH18/GH13 catalytic core loops,False,no_term_above_threshold +11733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor helix,False,no_term_above_threshold +11734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metallopeptidase catalytic core,False,no_term_above_threshold +11735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal mature region caps,False,no_term_above_threshold +11736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic transmembrane helix bundles,False,no_term_above_threshold +11737,38317,17.67584,0.9453125,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8798828,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9048888888888889,0.06375525927089022,0.0031014621178555605,,20.556517167771318,0.0,20.0,0.0,1.0,Helix initiation and capping,True,assigned_and_evaluated +11738,42974,16.8225,0.97558594,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.91845703,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9181904761904762,0.1359055338322455,0.0031014621178555605,,43.819827122768295,0.0,15.0,0.0,1.0,PAS N-cap loop motif,True,assigned_and_evaluated +11739,38317,15.649062,0.7524414,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7524414,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8325079365079365,0.03394883291268301,0.0031014621178555605,,10.946073697703651,0.0,18.0,0.0,1.0,Extracellular alpha-helical cores,True,assigned_and_evaluated +11740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16 metalloprotease fold,False,no_term_above_threshold +11741,87697,21.574892,0.8413086,Knottin,keyword,87697,Knottin,0.8413086,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8540207162840164,0.0549455554275458,0.017279574656623838,,3.1797979128197658,0.0,18.0,0.0,1.0,Trp-centered beta-strand anchors,True,assigned_and_evaluated +11742,85664,15.587622,0.90771484,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8144531,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,16.0,0.0,1.0,Hydrophobic His-Pro surface segment,True,assigned_too_few_test_positives +11743,69093,16.832977,0.9863281,"ANL, N-terminal domain",interpro,69093,"ANL, N-terminal domain",0.9863281,40,ip,IPR042099,interpro:ip:IPR042099,,,,,,,,17.0,17.0,522.9912280701755,4.702038889110484e-46,ANL ATP P-loop motif,True,assigned_too_few_test_positives +11744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting and regulatory segments,False,no_term_above_threshold +11745,81858,16.60719,0.9555664,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7285156,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Cytosolic juxtamembrane amphipathic helices,True,assigned_too_few_test_positives +11746,36914,17.587147,0.82373047,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7036133,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,3.0,11.0,200.74410774410774,7.681253900153669e-07,Membrane-adjacent catalytic domains,True,assigned_too_few_test_positives +11747,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compositionally biased disordered tails,False,no_term_above_threshold +11748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/disordered segments,False,no_term_above_threshold +11749,63951,23.724745,0.9824219,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.8154297,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9976275207591934,0.6789486838506447,0.003987594151528578,0.4444444444444444,170.2652421612117,15.0,15.0,161.13783783783785,2.7075535945833885e-33,Ig-like and MHC-like glycoproteins,True,assigned_and_evaluated +11750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted hydrolase catalytic surfaces,False,no_term_above_threshold +11751,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anaerobic corrinoid/Fe-S redox cores,False,no_term_above_threshold +11752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAPS dependent sulfotransferase domain,False,no_term_above_threshold +11753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic N-terminal regulatory tails,False,no_term_above_threshold +11754,38317,16.30431,0.77246094,Pentatricopeptide repeat,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.7685547,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6920000000000001,0.01959459767915333,0.0031014621178555605,,6.317858137407009,5.0,18.0,106.84767025089606,1.908117126563214e-09,Smr nuclease and disordered flanks,True,assigned_and_evaluated +11755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse N-terminal HIT/sugar signature,False,no_term_above_threshold +11756,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Buried hydrophobic beta strands,False,no_term_above_threshold +11757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic membrane-interacting helices,False,no_term_above_threshold +11758,45290,20.739378,0.95751953,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.95751953,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9853969559851913,0.3298058339896254,0.0057598582188746125,,57.2593667165065,1.0,16.0,4.5890548029556655,0.31136742210639545,Hydrophobic-acidic active-site motifs,True,assigned_and_evaluated +11759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular and periplasmic domains,False,no_term_above_threshold +11760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemoreceptor coiled-coil stalks,False,no_term_above_threshold +11761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ntn acylase alpha subunit,False,no_term_above_threshold +11762,49061,34.899082,0.9897461,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9897461,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9985259245016984,0.7769001751582694,0.012405848471422242,1.0,62.62370340472193,5.0,19.0,26.019464083093304,2.06835749000972e-06,Beta-strand repeat linker loops,True,assigned_and_evaluated +11763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic envelope linker helices,False,no_term_above_threshold +11764,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent DNA-processing catalytic modules,False,no_term_above_threshold +11765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic ligand-binding alpha/beta core,False,no_term_above_threshold +11766,49061,16.022577,0.7402344,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.7402344,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9892488623982568,0.3600542201739986,0.012405848471422242,0.6428571428571429,29.02294196188267,3.0,17.0,17.44834650278022,0.0011141074669768613,Beta-propeller and EF-hand loops,True,assigned_and_evaluated +11767,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic helical assembly scaffolds,False,no_term_above_threshold +11768,49116,16.588713,0.8310547,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8310547,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9770426287744227,0.06961017740429505,0.002215330084182543,,31.42203408029879,0.0,19.0,0.0,1.0,Coil-to-helix N-caps,True,assigned_and_evaluated +11769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDR helical docking motifs,False,no_term_above_threshold +11770,50806,20.07212,0.8486328,"Homeobox, conserved site",interpro,37071,Homeodomain,0.7861328,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,18.0,0.0,1.0,Post-His DHp/HPt helix,True,assigned_too_few_test_positives +11771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembranous catalytic domains,False,no_term_above_threshold +11772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal membrane-proximal extracytoplasmic interface,False,no_term_above_threshold +11773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich binding domains,False,no_term_above_threshold +11774,85649,32.68301,0.97021484,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.96435547,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8844245066365654,0.6545468108590785,0.0101905183872397,0.6521739130434783,64.23096313517131,17.0,17.0,110.61410018552876,7.110790058883305e-35,SAM pocket helix-beta junctions,True,assigned_and_evaluated +11775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal tail hotspots,False,no_term_above_threshold +11776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated disordered N-termini,False,no_term_above_threshold +11777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Global activation, C-terminal maxima",False,no_term_above_threshold +11778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal functional modules,False,no_term_above_threshold +11779,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-start hydrophobic α-helix,False,no_term_above_threshold +11780,30856,16.166166,0.7836914,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.6689453,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7448934280639432,0.01031476239670932,0.002215330084182543,,4.656083745874588,0.0,13.0,0.0,1.0,Transmembrane helix packing cores,True,assigned_and_evaluated +11781,38654,23.933893,0.99609375,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.98339844,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,16.0,0.0,1.0,Nucleotide and phosphate-binding alpha/beta cores,True,assigned_too_few_test_positives +11782,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pepsin-like aspartyl protease boundary signal,False,no_term_above_threshold +11783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich regulatory IDRs,False,no_term_above_threshold +11784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-rich DNA-binding catalytic domains,False,no_term_above_threshold +11785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and acyltransferase helix,False,no_term_above_threshold +11786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered regulatory N-termini and tails,False,no_term_above_threshold +11787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UDG substrate-recognition loop,False,no_term_above_threshold +11788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial enzyme N-termini,False,no_term_above_threshold +11789,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine-rich proline-directed IDRs,False,no_term_above_threshold +11790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic charge-flanked motifs,False,no_term_above_threshold +11791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter helix–loop TM boundaries,False,no_term_above_threshold +11792,24983,19.36478,0.69384766,mitochondrial inner membrane,go_cc,24983,mitochondrial inner membrane,0.69384766,179,go,GO:0005743,go_cc:go:GO:0005743,20.0,2257.0,0.7335493965131874,0.34800249261590904,0.008861320336730172,0.35,39.27208129170534,11.0,14.0,47.127838459327386,2.2311740237660033e-17,Mitochondrial carrier TM helices,True,assigned_and_evaluated +11793,64596,29.512417,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,13.0,14.0,570.7459499263623,1.805261603841075e-35,MBL/PDEase early beta-hairpin scaffold,True,assigned_too_few_test_positives +11794,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine recombinase catalytic domain,False,no_term_above_threshold +11795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BY-kinase cytoplasmic linker,False,no_term_above_threshold +11796,58239,33.618225,0.89453125,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.89453125,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8158942264321155,0.054987142266606504,0.017722640673460344,,3.1026495023932723,8.0,8.0,35.851473241130485,7.989762205581624e-13,P-loop NTPase helical transducers,True,assigned_and_evaluated +11797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,2OG oxygenase N-terminal cap,False,no_term_above_threshold +11798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical packing faces,False,no_term_above_threshold +11799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc metalloprotease mature N-terminus,False,no_term_above_threshold +11800,64620,16.03308,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8613281,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,16.0,16.0,324.0271739130435,3.056549823728774e-40,Histidine kinase D-box helix,True,assigned_too_few_test_positives +11801,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity Ser/Thr/Pro-rich IDRs,False,no_term_above_threshold +11802,36668,18.575058,1.0,AMP-dependent synthetase/ligase domain,interpro,63774,RNA-binding domain superfamily,0.7495117,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,13.0,13.0,532.3303571428571,9.561000563003835e-36,ANL adenylation active site loops,True,assigned_too_few_test_positives +11803,45714,16.566883,0.7470703,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.7470703,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,19.0,0.0,1.0,DHp alpha2 phosphatase determinant,True,assigned_too_few_test_positives +11804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical scaffold signature,False,no_term_above_threshold +11805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved surface functional patches,False,no_term_above_threshold +11806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil scaffolds,False,no_term_above_threshold +11807,82029,22.852802,0.9916992,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6152344,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,Transporter TM helix cores,True,assigned_too_few_test_positives +11808,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Gly-anchored pre-β loop,False,no_term_above_threshold +11809,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed β-edge loops and linkers,False,no_term_above_threshold +11810,27733,21.080122,0.8491211,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,87384,DNA-binding,0.6123047,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8321591218714725,0.25810254626737894,0.0101905183872397,0.13043478260869565,25.32771508371627,11.0,17.0,34.75521992580816,2.3323201669255416e-15,Low-complexity regulatory IDRs,True,assigned_and_evaluated +11811,88160,21.436628,0.8383789,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6972656,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,19.0,19.0,289.42233009708735,2.1602333461059206e-46,Outer-membrane β-barrel detector,True,assigned_too_few_test_positives +11812,87326,22.756737,0.65234375,Coiled coil,keyword,87326,Coiled coil,0.65234375,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6531728098179858,0.10879348952121609,0.03943287549844927,0.06741573033707865,2.7589539983076934,5.0,14.0,4.502688578074495,0.00589136043292304,Amphipathic coiled‑coil interfaces,True,assigned_and_evaluated +11813,85712,18.599962,0.7236328,3.40.630.30,gene3d,85712,3.40.630.30,0.7236328,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,10.0,15.0,189.27301587301585,1.8905573807742557e-21,Acyltransferase donor-binding lid,True,assigned_too_few_test_positives +11814,64148,17.306393,0.7011719,Winged helix DNA-binding domain superfamily,interpro,27918,DNA-binding transcription factor activity,0.64990234,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.699390903532289,0.0404322905076899,0.008418254319893664,,4.802930509255584,8.0,17.0,41.87603160667252,1.1753720322182537e-11,Bacterial N-terminal activation,True,assigned_and_evaluated +11815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD helical N-cap,False,no_term_above_threshold +11816,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-transmembrane C-terminal activation,False,no_term_above_threshold +11817,52940,16.729488,0.9995117,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.9482422,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,13.0,14.0,564.9220116618076,2.077278695314146e-35,AMP-binding ATP-lid loop,True,assigned_too_few_test_positives +11818,36115,15.825448,0.83691406,BTB/POZ domain,interpro,37468,"Zinc finger, RING-type",0.7939453,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,17.0,0.0,1.0,Terminal sorting/anchoring signals,True,assigned_too_few_test_positives +11819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural helix/alpha/beta scaffolds,False,no_term_above_threshold +11820,46277,17.928938,0.9614258,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9614258,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9362300655711163,0.16366476996601495,0.004873726185201595,,33.58103507393598,0.0,13.0,0.0,1.0,Generic beta-strand core signal,True,assigned_and_evaluated +11821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical packing and capping detector,False,no_term_above_threshold +11822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar beta-edge loop motif,False,no_term_above_threshold +11823,59224,17.36935,0.9121094,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9121094,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9695873015873016,0.052185217203910825,0.0031014621178555605,,16.826005032746675,0.0,17.0,0.0,1.0,LacI/GalR effector-binding residues,True,assigned_and_evaluated +11824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine biased beta strand boundary,False,no_term_above_threshold +11825,88058,39.239025,0.6855469,Signal,keyword,88058,Signal,0.6855469,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6789773399667698,0.24596988389682015,0.09127159946832078,0.12135922330097088,2.6949224658015685,11.0,15.0,5.283633434038268,5.65380393494368e-07,Extracytoplasmic alpha-helical segments,True,assigned_and_evaluated +11826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic N-terminal nucleic acid binders,False,no_term_above_threshold +11827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclic nucleotide catalytic domains,False,no_term_above_threshold +11828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GCS/NTP catalytic motif,False,no_term_above_threshold +11829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent loop motifs,False,no_term_above_threshold +11830,38873,20.097029,0.9868164,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9477539,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9994671403197157,0.8444444444444443,0.002215330084182543,1.0,381.1822222222222,9.0,9.0,171.32471264367817,1.8650004750458193e-20,Pre-Walker A beta-strand activation,True,assigned_and_evaluated +11831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CENP-V/GFA domain-wide activation,False,no_term_above_threshold +11832,-1,,,,,-1,,,0,,,,,,,,,,,,,,,General secondary-structure propensity,False,no_term_above_threshold +11833,37894,23.099714,1.0,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8769531,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,8.0,709.7738095238095,3.1343957826349425e-23,SDR Rossmann cofactor-binding loop,True,assigned_too_few_test_positives +11834,59224,18.64793,0.90283203,Alpha/Beta hydrolase fold,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.859375,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9506984126984127,0.07679898181943053,0.0031014621178555605,,24.762185995207812,5.0,19.0,36.151467378122724,4.174136536270081e-07,Capping/hinge helices,True,assigned_and_evaluated +11835,37640,17.277464,0.9746094,EF-hand domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9584961,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,18.0,0.0,1.0,HTH beta-strand N-cap residue,True,assigned_too_few_test_positives +11836,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal IDR and flanking elements,False,no_term_above_threshold +11837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Gly-rich disordered linkers,False,no_term_above_threshold +11838,81799,18.971502,0.92285156,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73779297,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,5.0,9.0,321.5803667745415,3.815160537588821e-12,AAA+ Walker-B coupling helix,True,assigned_too_few_test_positives +11839,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral non-catalytic enzyme regions,False,no_term_above_threshold +11840,82029,35.34355,0.99365234,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9819336,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,20.0,169.27097791798107,9.692152584541787e-39,MFS transmembrane helix marker,True,assigned_too_few_test_positives +11841,63960,21.773932,0.70654297,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.70654297,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,15.0,17.0,170.80118411000763,2.0700474577799798e-32,C-terminal β-sandwich cap,True,assigned_too_few_test_positives +11842,64168,16.122065,0.8144531,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.8144531,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.6800177619893427,0.01281988128032319,0.002215330084182543,,5.786894409937888,0.0,16.0,0.0,1.0,Phosphate-gripper active-site loops,True,assigned_and_evaluated +11843,49061,28.500715,0.9746094,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9746094,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9934147279369352,0.4501264724198484,0.012405848471422242,1.0,36.28340886612849,2.0,18.0,10.98599594619495,0.02379117681115596,Extracellular Gly-Pro beta-turn repeats,True,assigned_and_evaluated +11844,85364,18.905266,0.71728516,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.71728516,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,10.0,13.0,231.62781662781666,1.0287810030681268e-22,Membrane-insertion helices and juxtamembrane regions,True,assigned_too_few_test_positives +11845,47529,16.674706,0.87646484,Immunoglobulin-like fold,interpro,87413,Disulfide bond,0.66748047,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9121904283801874,0.09743411221978536,0.007089056269384138,,13.744299455003473,3.0,20.0,11.599416342412452,0.0036188049688884822,Edge beta-strand motif,True,assigned_and_evaluated +11846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MacB periplasmic GxGFGD motif,False,no_term_above_threshold +11847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxidoreductase–PARP catalytic motif,False,no_term_above_threshold +11848,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic low-complexity N-terminal leader,False,no_term_above_threshold +11849,31094,15.825557,0.9658203,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.82128906,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9986203827325323,0.7171031746031746,0.004430660168365086,0.9,161.8501865079365,8.0,15.0,378.54603174603176,1.8015575005659658e-19,FabD/AT acyltransferase fold,True,assigned_and_evaluated +11850,85656,25.331747,0.9941406,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.99316406,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9993968253968254,0.8500927643784786,0.0031014621178555605,1.0,274.094195600318,18.0,18.0,141.281990521327,9.999057839062593e-39,Alpha/beta-hydrolase active-site loops,True,assigned_and_evaluated +11851,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helix cores,False,no_term_above_threshold +11852,50806,17.088142,0.97753906,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.8486328,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,PDZ-PBM glycine-loop docking,True,assigned_too_few_test_positives +11853,64003,21.312927,0.97216797,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.80322266,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9960211546065639,0.6846995596995598,0.003987594151528578,0.5555555555555556,171.7074340268785,13.0,14.0,121.14301344170053,1.1855690738493202e-26,Tandem C2H2 zinc fingers,True,assigned_and_evaluated +11854,36499,24.567102,0.9638672,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.9638672,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,16.0,0.0,1.0,Modular delivery/binding/pore ectodomains,True,assigned_too_few_test_positives +11855,88058,81.96793,0.90234375,Signal,keyword,88058,Signal,0.90234375,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9296081002399967,0.6835370176919653,0.09127159946832078,0.8932038834951457,7.489043926848377,12.0,18.0,4.803303121852971,8.061376574365849e-07,Signal peptide/anchor boundary,True,assigned_and_evaluated +11856,36668,20.47752,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9868164,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,15.0,15.0,532.3303571428571,4.765377825901055e-41,Adenylation core helical motif,True,assigned_too_few_test_positives +11857,82029,33.056988,0.9941406,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,12.0,17.0,132.76155130822045,7.333085228743763e-24,MFS symmetric helix-loop gates,True,assigned_too_few_test_positives +11858,37071,20.294199,0.99072266,Homeodomain,interpro,87384,DNA-binding,0.64208984,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,3.0,17.0,36.40606554040301,0.00013337445434367893,DBD-adjacent disordered regulatory segments,True,assigned_too_few_test_positives +11859,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrophobic oligomerization interface,False,no_term_above_threshold +11860,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral domain boundary linkers,False,no_term_above_threshold +11861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs with helical SLiMs,False,no_term_above_threshold +11862,49236,21.994701,0.96191406,C-type lectin fold,interpro,49236,C-type lectin fold,0.96191406,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,13.0,13.0,542.0090909090909,7.54613259578455e-36,Extracellular disulfide rich recognition domains,True,assigned_and_evaluated +11863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,R3H domain with acidic IDRs,False,no_term_above_threshold +11864,87326,42.699844,0.7993164,Coiled coil,keyword,87326,Coiled coil,0.7993164,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8296052904349268,0.316892180380816,0.03943287549844927,0.550561797752809,8.036243271005638,18.0,20.0,11.346775216747726,6.031390779229954e-18,Coiled-coil dimerization interface,True,assigned_and_evaluated +11865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-proximal acidic catalytic loops,False,no_term_above_threshold +11866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil interfaces and catalytic sites,False,no_term_above_threshold +11867,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged flexible active-site interfaces,False,no_term_above_threshold +11868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha helix,False,no_term_above_threshold +11869,85672,20.16672,0.6123047,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.6123047,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6045199859922957,0.15155278761836138,0.01595037660611431,0.16666666666666666,9.501517823740047,17.0,17.0,40.01409395973155,1.7557395315514075e-27,P-loop helicase motor core,True,assigned_and_evaluated +11870,85656,16.72642,0.86572266,alpha/beta hydrolase,gene3d,64317,"Knottin, scorpion toxin-like superfamily",0.84521484,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9232380952380953,0.022221502558580002,0.0031014621178555605,,7.164847324959295,0.0,18.0,0.0,1.0,Thr/Asp-rich active-site loops,True,assigned_and_evaluated +11871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-to-C-terminal leucine-rich hydrophobic motifs,False,no_term_above_threshold +11872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cation channel pore-domain helices,False,no_term_above_threshold +11873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Ser-rich domain-flanking IDRs,False,no_term_above_threshold +11874,52941,20.975992,0.99902344,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9897461,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,19.0,19.0,260.353711790393,1.5255431321768337e-45,MFS/SLC interface gating residues,True,assigned_too_few_test_positives +11875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-zipper TM helix starts,False,no_term_above_threshold +11876,64596,33.27566,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,13.0,13.0,614.6494845360825,1.4173313179671264e-36,MBL fold HxH catalytic core,True,assigned_too_few_test_positives +11877,39177,16.116997,0.9433594,Fibronectin type III,interpro,47529,Immunoglobulin-like fold,0.81103516,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,0.0,7.0,0.0,1.0,Polar beta-sheet ligand interfaces,True,assigned_too_few_test_positives +11878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane extracellular SEA domains,False,no_term_above_threshold +11879,82716,15.8569145,0.98339844,Laminin,gene3d,87413,Disulfide bond,0.7792969,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,16.0,16.0,289.42233009708735,1.7947129330365298e-39,Extracellular beta-strand entry motifs,True,assigned_too_few_test_positives +11880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Moco-binding β-sheet edge motifs,False,no_term_above_threshold +11881,37690,27.240582,0.9970703,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9970703,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9994285714285716,0.7253968253968255,0.0031014621178555605,1.0,233.8886621315193,17.0,17.0,180.66969696969696,1.989737557278833e-38,Ankyrin-repeat helix-start N-cap,True,assigned_and_evaluated +11882,45324,23.034184,0.9638672,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9638672,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9908525754884547,0.12207504250982512,0.002215330084182543,,55.104674188935064,13.0,15.0,474.0507645259939,6.098943990571642e-34,Glycan-binding beta-strand cap,True,assigned_and_evaluated +11883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-acidic polysaccharide-binding groove,False,no_term_above_threshold +11884,88161,19.0618,0.6010742,Transmembrane helix,keyword,88161,Transmembrane helix,0.6010742,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5904480763215515,0.2154727939028505,0.1847585290208241,,1.1662400379825746,1.0,14.0,0.3876780024709019,1.0,uS13 C-terminal Ala motif,True,assigned_and_evaluated +11885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenosyl/phosphate-binding loop signature,False,no_term_above_threshold +11886,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular ligand-sensing ectodomains,False,no_term_above_threshold +11887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved motif residue peaks,False,no_term_above_threshold +11888,50806,15.903669,0.9794922,"Homeobox, conserved site",interpro,87384,DNA-binding,0.70947266,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,3.0,17.0,50.341401632423306,5.1483807459325424e-05,HTH recognition helix residues,True,assigned_too_few_test_positives +11889,64148,34.971,0.87597656,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.87597656,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8331216781901133,0.40338644122996004,0.008418254319893664,0.3157894736842105,47.91806304505368,19.0,19.0,88.9865671641791,4.383349844353145e-37,Post-HTH basic linker helix,True,assigned_and_evaluated +11890,69819,28.334885,0.9135742,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.88671875,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,17.0,17.0,419.86619718309856,1.776833158726609e-44,Sugar-kinase small-subdomain loop-helix,True,assigned_too_few_test_positives +11891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical surface patch,False,no_term_above_threshold +11892,87697,18.0629,0.8461914,Knottin,keyword,87413,Disulfide bond,0.6699219,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9106899262444799,0.08428128427264793,0.017279574656623838,,4.877509194958112,0.0,18.0,0.0,1.0,Beta strand-to-loop junctions,True,assigned_and_evaluated +11893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Dynamin-like helical stalk/paddle,False,no_term_above_threshold +11894,87882,19.934599,0.7392578,Palmitate,keyword,88058,Signal,0.68603516,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.7123870872204946,0.039067038169997806,0.002658396101019052,,14.695717524947508,9.0,16.0,37.471298882681566,8.573881334319926e-13,N-terminal low-complexity tether,True,assigned_and_evaluated +11895,85364,16.4184,0.99072266,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.99072266,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,18.0,200.74410774410774,7.313713037197334e-26,Clamshell LBD ligand edges,True,assigned_too_few_test_positives +11896,72011,19.957312,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.94873047,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,15.0,17.0,520.8590564938847,1.0067571000336976e-39,ANL adenylation ATP-binding subdomain,True,assigned_too_few_test_positives +11897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-start beta-loop scaffold,False,no_term_above_threshold +11898,45551,23.025824,0.98779297,SKP1/BTB/POZ domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.71484375,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,15.0,0.0,1.0,AAA+ helix-loop-helix switch,True,assigned_too_few_test_positives +11899,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SET-domain substrate-recognition elements,False,no_term_above_threshold +11900,87856,16.147661,0.7294922,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7294922,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5314522848170223,0.05616257358060636,0.012405848471422242,0.03571428571428571,4.527104591836734,14.0,14.0,84.68892045454545,2.9630149843605392e-27,Polymerase right-hand helical core,True,assigned_and_evaluated +11901,58239,30.313168,0.66503906,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.66503906,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6459291835814165,0.18521522595241413,0.017722640673460344,0.275,10.450769124364967,17.0,17.0,35.851473241130485,1.1097904818074523e-26,Pre-P-loop Walker A region,True,assigned_and_evaluated +11902,87326,17.499031,0.62646484,Coiled coil,keyword,87326,Coiled coil,0.62646484,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.664307703470293,0.07704987282228871,0.03943287549844927,,1.9539501456169173,3.0,16.0,2.36391150348911,0.20600485057357215,Hydrophobic alpha-helical packing,True,assigned_and_evaluated +11903,87198,15.977204,0.7885742,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.7885742,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,10.0,17.0,427.69727403156384,7.9292749536536815e-25,C-terminal amphipathic helical tails,True,assigned_too_few_test_positives +11904,59211,20.743189,0.9897461,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,1.0,1.0,0.011076650420912717,1.0,90.28,18.0,18.0,244.34836065573774,7.288942336525665e-43,Glycosyltransferase donor-binding helix,True,assigned_and_evaluated +11905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet cofactor-binding core,False,no_term_above_threshold +11906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal domain start,False,no_term_above_threshold +11907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine turns and disordered linkers,False,no_term_above_threshold +11908,46078,20.83884,0.9814453,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9814453,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,17.0,19.0,116.98487996306555,6.291394647743322e-34,HEAT repeat A-helix/turn peaks,True,assigned_too_few_test_positives +11909,36010,19.139694,0.9848633,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9042969,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,2.0,11.0,92.65112665112666,0.0003747861076824365,AB-hydrolase N-terminal lid,True,assigned_too_few_test_positives +11910,36104,16.372526,0.97558594,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.97558594,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Short amphipathic interaction helix,True,assigned_too_few_test_positives +11911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short Lys/Arg-rich patches,False,no_term_above_threshold +11912,25884,16.649446,0.7392578,host cell membrane,go_cc,88161,Transmembrane helix,0.64160156,259,go,GO:0033644,go_cc:go:GO:0033644,24.0,2257.0,0.7931221077772803,0.045774963449043554,0.010633584404076208,,4.304753854353804,1.0,18.0,7.426631788739411,0.20265546670574075,Single-pass signal-anchor helix,True,assigned_and_evaluated +11913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Low-complexity IDRs, TruA Asp",False,no_term_above_threshold +11914,36104,15.57634,0.8486328,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8486328,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Mobile C-terminal cap/hinge segments,True,assigned_too_few_test_positives +11915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered small-residue tandem repeats,False,no_term_above_threshold +11916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking micro-motifs,False,no_term_above_threshold +11917,46932,19.775518,0.9428711,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.9428711,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9578549176680018,0.11546957114412364,0.004430660168365086,,26.061482207228707,1.0,16.0,6.762817604355717,0.22017336667883902,Aromatic strand-helix anchor,True,assigned_and_evaluated +11918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small/polar surface-loop motif,False,no_term_above_threshold +11919,47529,21.698883,0.84277344,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.84277344,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8525351405622491,0.27220615883126126,0.007089056269384138,0.375,38.39808128013479,7.0,19.0,28.489794525223566,5.283737104858649e-09,Short extracellular exposed loops,True,assigned_and_evaluated +11920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane TM-helix boundary motif,False,no_term_above_threshold +11921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular FAS1-domain modules,False,no_term_above_threshold +11922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-beta junction loops,False,no_term_above_threshold +11923,64475,15.807778,0.87353516,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.8515625,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9213972302207597,0.675014994624074,0.0057598582188746125,0.8461538461538461,117.19298791281038,0.0,18.0,0.0,1.0,PPK N-terminal ATP-binding hotspot,True,assigned_and_evaluated +11924,85672,18.782013,0.7363281,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7294922,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7630884486467557,0.05055247261119905,0.01595037660611431,,3.1693591856521186,4.0,20.0,8.002818791946309,0.002389417577974755,Charged surface capping motifs,True,assigned_and_evaluated +11925,63951,18.737669,0.8857422,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.86572266,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8749011466982997,0.11818806732073339,0.003987594151528578,,29.63894088254392,0.0,15.0,0.0,1.0,Interdomain PxH linker block,True,assigned_and_evaluated +11926,36091,15.612529,0.9951172,GNAT domain,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96875,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,9.0,18.0,188.6740506329114,6.170006583561942e-19,Small-residue beta-strand hotspots,True,assigned_too_few_test_positives +11927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal tail to first helix,False,no_term_above_threshold +11928,47529,27.276442,0.95654297,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.95654297,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9948683623382418,0.4918513805154453,0.007089056269384138,0.5,69.38178536396,4.0,16.0,19.33236057068742,8.208016083738368e-05,CLCA extracellular DGxYSR motif,True,assigned_and_evaluated +11929,43583,18.199371,0.9501953,"Peptidase S1, PA clan",interpro,85364,Periplasmic binding protein-like II,0.71484375,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,10.0,10.0,416.9300699300699,1.4595016026239996e-26,Chymotrypsin-like catalytic core,True,assigned_and_evaluated +11930,45288,15.707194,0.9746094,CheY-like superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.9248047,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,11.0,19.0,267.57690738474093,7.0385908079098475e-25,HATPase_c C-terminal loop,True,assigned_too_few_test_positives +11931,27735,25.127111,0.8666992,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,87384,DNA-binding,0.6357422,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.890356170051374,0.26385428177076525,0.011519716437749225,,22.904581306023736,2.0,18.0,5.026218175687068,0.09707461405856672,TF N-terminal regulatory IDR,True,assigned_and_evaluated +11932,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil scaffolds,False,no_term_above_threshold +11933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved C-terminal beta-strand,False,no_term_above_threshold +11934,87735,16.539959,0.6171875,Lipoprotein,keyword,87735,Lipoprotein,0.6171875,423,keywords,Lipoprotein,keyword:keywords:Lipoprotein,20.0,2257.0,0.6000670540902995,0.01668745264301015,0.008861320336730172,,1.8831790307636955,11.0,20.0,19.849606537530267,2.1016626823406254e-12,Post-signal peptide N-terminal module,True,assigned_and_evaluated +11935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic accessory/catalytic C-termini,False,no_term_above_threshold +11936,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical scaffold activation,False,no_term_above_threshold +11937,36668,16.586245,0.96777344,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.93066406,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,17.0,0.0,1.0,TFIIB B-reader linker,True,assigned_too_few_test_positives +11938,36104,22.464993,0.8769531,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8769531,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,20.0,0.0,1.0,Active-site cleft loops,True,assigned_too_few_test_positives +11939,85656,16.780558,0.91845703,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7861328,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9496825396825397,0.05733721467987654,0.0031014621178555605,,18.487156218925907,0.0,19.0,0.0,1.0,Helix-strand capping turns,True,assigned_and_evaluated +11940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic mid-domain binding patches,False,no_term_above_threshold +11941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAM/dcSAM transferase modules,False,no_term_above_threshold +11942,36104,18.340721,0.9511719,Rho GTPase-activating protein domain,interpro,25169,pilus,0.8027344,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Polar beta-loop adhesion sites,True,assigned_too_few_test_positives +11943,45290,16.706608,0.9013672,Protein kinase-like domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.76904297,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9564993829699712,0.17383713202757434,0.0057598582188746125,,30.180800537402714,0.0,14.0,0.0,1.0,Active-site proximal loops,True,assigned_and_evaluated +11944,50869,16.218384,0.984375,"DNA binding HTH domain, AraC-type",interpro,46932,Zinc finger C2H2-type,0.9741211,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,1.0,18.0,50.95811965811965,0.032777848966225605,Histidine kinase N-box asparagine,True,assigned_too_few_test_positives +11945,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtacatalytic substrate-recognition segment,False,no_term_above_threshold +11946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,eIF5B/IF2 C-terminal domain IV,False,no_term_above_threshold +11947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Propeptide N-glycosylation sequon,False,no_term_above_threshold +11948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear DNA/RNA-binding domains,False,no_term_above_threshold +11949,36876,16.572363,0.9995117,Cytochrome P450,interpro,36876,Cytochrome P450,0.9995117,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,389.6797385620915,6.157114732498076e-44,Cytochrome P450 K-helix/meander module,True,assigned_and_evaluated +11950,81858,19.512741,0.9453125,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6791992,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Membrane-entry TM helices,True,assigned_too_few_test_positives +11951,87413,15.9727545,0.60546875,Disulfide bond,keyword,87413,Disulfide bond,0.60546875,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.5553139456082972,0.09477146006420101,0.0717766947275144,0.006172839506172839,1.3203653417586523,3.0,15.0,2.3654433644118233,0.20499428397143085,Surface beta-edge micro-motifs,True,assigned_and_evaluated +11952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular helix→β loop transitions,False,no_term_above_threshold +11953,29034,16.019032,0.66748047,GTP binding,go_mf,29034,GTP binding,0.66748047,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.6184175234689316,0.23831265691921427,0.008861320336730172,0.25,26.893583333333332,15.0,18.0,108.0090579710145,4.665834253692246e-29,Helical scaffolds flanking GTPases,True,assigned_and_evaluated +11954,81858,15.768825,0.6513672,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.6513672,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,GT-C TM-loop catalytic junctions,True,assigned_too_few_test_positives +11955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IPPT adenosine prenyltransferase core,False,no_term_above_threshold +11956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed edge beta-strand motif,False,no_term_above_threshold +11957,25014,15.760861,0.8017578,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.72265625,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.7078693583644078,0.1018009151006836,0.015507310589277802,,6.564704725206941,2.0,18.0,4.094286499107265,0.13752497001024308,Transmembrane and pore helices,True,assigned_and_evaluated +11958,36010,20.225054,0.9560547,Alpha/beta hydrolase fold-1,interpro,36010,Alpha/beta hydrolase fold-1,0.9560547,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,14.0,0.0,1.0,Cyclic nucleotide hydrophobic pocket framework,True,assigned_too_few_test_positives +11959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PafA SQR(A/S)D catalytic motif,False,no_term_above_threshold +11960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta/alpha catalytic core,False,no_term_above_threshold +11961,49116,22.053009,0.97216797,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.97216797,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.999911190053286,0.9666666666666666,0.002215330084182543,1.0,436.3533333333333,16.0,17.0,81.91807642765136,4.9264532747787625e-30,HEAT/ARM alpha-solenoid repeats,True,assigned_and_evaluated +11962,39958,16.156164,0.90771484,Basic-leucine zipper domain,interpro,87681,Iron-sulfur,0.8364258,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9859691988745742,0.09517483898138894,0.002658396101019052,,35.8016019301658,0.0,15.0,0.0,1.0,Fe-S flanking helix-loop scaffold,True,assigned_and_evaluated +11963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic Pro/His-rich low-complexity,False,no_term_above_threshold +11964,37640,23.675316,0.9975586,EF-hand domain,interpro,46081,EF-hand domain pair,0.9916992,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,13.0,17.0,229.1081879988176,3.64402535006339e-29,Ca2+-signaling disordered regions,True,assigned_too_few_test_positives +11965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-A glycosyltransferase catalytic domains,False,no_term_above_threshold +11966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble low‑Cys polar stretches,False,no_term_above_threshold +11967,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic Gly/Pro-rich catalytic loop,False,no_term_above_threshold +11968,64168,24.179068,0.7866211,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.7866211,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.8989342806394316,0.4537763993501698,0.002215330084182543,0.8,204.83466666666666,10.0,10.0,334.9494382022472,1.3456627591790083e-25,P-type ATPase catalytic headpiece,True,assigned_and_evaluated +11969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sparse motif hotspot detector,False,no_term_above_threshold +11970,64155,17.770683,0.7602539,Ribonuclease H superfamily,interpro,64155,Ribonuclease H superfamily,0.7602539,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,15.0,17.0,244.68262653898768,9.378114214926556e-35,DEDD exonucleases peripheral activation,True,assigned_too_few_test_positives +11971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended intermembrane lipid-transfer proteins,False,no_term_above_threshold +11972,87601,15.641161,0.6176758,Hydrolase,keyword,87601,Hydrolase,0.6176758,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6352226641709562,0.11826495440178005,0.05316792202038104,0.008333333333333333,2.224366684040146,8.0,15.0,5.964709560432689,2.7337276937054956e-05,Conserved RTEL1 loop motifs,True,assigned_and_evaluated +11973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane disordered tails,False,no_term_above_threshold +11974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial TM–loop boundary motifs,False,no_term_above_threshold +11975,87601,19.022707,0.6347656,Hydrolase,keyword,87601,Hydrolase,0.6347656,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6297165028856653,0.08785064213354976,0.05316792202038104,,1.6523241607951817,4.0,17.0,2.631489511955598,0.09707461405856672,Catalytic headgroup-binding pocket,True,assigned_and_evaluated +11976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro hinge/cleavage motifs,False,no_term_above_threshold +11977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD monooxygenase C-terminal cap,False,no_term_above_threshold +11978,27932,18.353357,0.6074219,structural constituent of ribosome,go_mf,27932,structural constituent of ribosome,0.6074219,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.5101569239617137,0.04701786361622427,0.01949490474080638,0.022727272727272728,2.4118026859504136,0.0,14.0,0.0,1.0,Pseudouridine synthase catalytic core,True,assigned_and_evaluated +11979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase DHp H-box helix,False,no_term_above_threshold +11980,82029,20.766605,0.9707031,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.67578125,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,19.0,9.898887597542751,0.15603218450951648,Small-residue membrane helix hotspots,True,assigned_too_few_test_positives +11981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal basic-aromatic signal patches,False,no_term_above_threshold +11982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosidase-like alpha/beta core,False,no_term_above_threshold +11983,37894,23.613413,0.86328125,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.86328125,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,AAA+ C-terminal collar helices,True,assigned_too_few_test_positives +11984,36886,27.176851,0.99560547,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.99560547,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9358048021342819,0.5558272651510356,0.003544528134692069,0.75,156.81276718073593,18.0,18.0,233.80784313725488,1.5159322438572416e-42,Acidic transcriptional activation IDRs,True,assigned_and_evaluated +11985,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal TM helices and tails,False,no_term_above_threshold +11986,37071,23.364952,0.984375,Homeodomain,interpro,87384,DNA-binding,0.6123047,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,14.0,14.0,206.30103806228374,1.2714014319586377e-32,Homeobox N-terminal activation IDRs,True,assigned_too_few_test_positives +11987,36535,22.642857,0.9941406,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.953125,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9987093902981753,0.6436435786435787,0.004430660168365086,0.9,145.2703556998557,0.0,16.0,0.0,1.0,GHKL N-box ATP-lid residue,True,assigned_and_evaluated +11988,85762,30.322807,0.9121094,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.90625,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,Flavoenzyme helical lid subdomain,True,assigned_too_few_test_positives +11989,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-processing/binding pockets,False,no_term_above_threshold +11990,46081,16.909597,0.9868164,EF-hand domain pair,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.85839844,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.997887950200089,0.4646825396825397,0.003544528134692069,1.0,131.09856150793652,0.0,11.0,0.0,1.0,Paired hydrophobic anchor motif,True,assigned_and_evaluated +11991,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM/juxtamembrane module,False,no_term_above_threshold +11992,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HTH-OST repeats and linkers,False,no_term_above_threshold +11993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter TM hairpins and boundaries,False,no_term_above_threshold +11994,37894,15.956608,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,85712,3.40.630.30,0.8984375,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,9.0,709.7738095238095,4.424699527134814e-26,Rossmann YXXXK active-site helix,True,assigned_too_few_test_positives +11995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mobile beta-alpha gating loop,False,no_term_above_threshold +11996,83419,16.483036,0.8779297,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.86621094,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,15.0,18.0,302.9522357723577,8.93547183013231e-36,Extracellular glycan-binding and ECM domains,True,assigned_too_few_test_positives +11997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal transmembrane helix exit,False,no_term_above_threshold +11998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase DxD acidic patch,False,no_term_above_threshold +11999,52236,17.639172,0.9682617,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.93359375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,10.0,18.0,124.05534748231378,2.9584673239211273e-19,Membrane tail-anchors and basic tails,True,assigned_too_few_test_positives +12000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M28 PG(I/A)ND(N/D)GSG motif,False,no_term_above_threshold +12001,59211,17.319798,0.7114258,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7114258,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.8986111111111112,0.8022153300841827,0.011076650420912717,0.8,72.424,17.0,17.0,244.34836065573774,1.3495568203358695e-40,Nucleotidylyltransferase beta1-alpha1 P-loop,True,assigned_and_evaluated +12002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical rod scaffolds,False,no_term_above_threshold +12003,25167,15.834014,0.6464844,cell outer membrane,go_cc,25167,cell outer membrane,0.6464844,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7029324424647365,0.33520022754995427,0.005316792202038104,0.3333333333333333,63.04557613168723,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane β-barrel LxPE motif,True,assigned_and_evaluated +12004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Pro/His helical motifs,False,no_term_above_threshold +12005,85791,16.186514,0.74853516,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.74853516,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,15.0,0.0,1.0,N-lobe basic substrate cap,True,assigned_too_few_test_positives +12006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zn/Mn-dependent C–N hydrolase fold,False,no_term_above_threshold +12007,38317,25.715593,0.9848633,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9848633,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9658412698412698,0.0467624666484376,0.0031014621178555605,,15.077555317931951,0.0,7.0,0.0,1.0,ABC NBD coupling helix,True,assigned_and_evaluated +12008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad structured-core interface activation,False,no_term_above_threshold +12009,88058,38.15317,0.7368164,Signal,keyword,88058,Signal,0.7368164,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6967096325259287,0.13516709460285958,0.09127159946832078,,1.4809326821293887,3.0,19.0,1.137624423596756,0.7800416838874774,Hydrophobic and leader-like segments,True,assigned_and_evaluated +12010,45317,16.187098,0.9946289,"Six-bladed beta-propeller, TolB-like",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97753906,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,6.0,17.0,269.77828054298647,1.1438674649106808e-13,β-strand initiation motifs,True,assigned_too_few_test_positives +12011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal and internal disordered linkers,False,no_term_above_threshold +12012,39958,18.033833,0.80126953,Basic-leucine zipper domain,interpro,38317,Pentatricopeptide repeat,0.70410156,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.8151192062786908,0.03906613179903863,0.002658396101019052,,14.69537657840503,0.0,10.0,0.0,1.0,Coiled-coil oligomerization stalks,True,assigned_and_evaluated +12013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted disordered low-complexity repeats,False,no_term_above_threshold +12014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical connector stalks,False,no_term_above_threshold +12015,59229,40.844875,0.9897461,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9897461,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.866295589895294,0.7417888308836277,0.0101905183872397,0.7391304347826086,72.79206049149337,17.0,17.0,106.27629233511585,1.3819031749869367e-34,SAM MTase cofactor loop,True,assigned_and_evaluated +12016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular N-linked glycoproteins,False,no_term_above_threshold +12017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic C-terminal toxin effectors,False,no_term_above_threshold +12018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ion transporter transmembrane helices,False,no_term_above_threshold +12019,37314,16.317806,0.99658203,"Helicase, C-terminal domain-like",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9770508,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,13.0,18.0,229.04048463356975,6.020944094959232e-29,Helicase C-terminal helical scaffold,True,assigned_too_few_test_positives +12020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich catalytic lid loops,False,no_term_above_threshold +12021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity S/T/P/G IDRs,False,no_term_above_threshold +12022,88160,16.208115,0.88427734,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7734375,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,19.0,243.7240674501788,1.2901271652930656e-36,Outer membrane beta-barrel strands,True,assigned_too_few_test_positives +12023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycine-rich active-site loops,False,no_term_above_threshold +12024,82029,17.189032,0.9350586,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8515625,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,Small-residue TM packing motifs,True,assigned_too_few_test_positives +12025,49061,35.52392,0.97998047,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97998047,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9936871114529258,0.4845186126299748,0.012405848471422242,0.9642857142857143,39.05566102520904,5.0,17.0,29.080577504633695,1.1255976555802215e-06,Beta-propeller blade motif detector,True,assigned_and_evaluated +12026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich SP/TP SH3 IDRs,False,no_term_above_threshold +12027,29104,20.440134,0.80908203,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.8041992,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,14.0,14.0,428.9280575539568,4.390925531224764e-37,Selected lipid-exposed TM helices,True,assigned_too_few_test_positives +12028,88161,37.850895,0.61816406,Transmembrane helix,keyword,88161,Transmembrane helix,0.61816406,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5981115107913669,0.3491475327803757,0.1847585290208241,0.22302158273381295,1.8897505551206426,15.0,15.0,5.4274920345926265,2.044231257442523e-11,Juxtamembrane TM-loop interfaces,True,assigned_and_evaluated +12029,87326,29.745472,0.671875,Coiled coil,keyword,87326,Coiled coil,0.671875,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.71914776732037,0.21525738162599828,0.03943287549844927,0.12359550561797752,5.4588304531446985,12.0,18.0,8.40501867907239,1.4878219757400116e-09,N-terminal globular core domains,True,assigned_and_evaluated +12030,37894,23.475882,0.8442383,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8442383,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,13.0,382.1858974358974,3.550068508452943e-17,Amphipathic terminal helical extensions,True,assigned_too_few_test_positives +12031,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed extracytoplasmic loops,False,no_term_above_threshold +12032,81799,18.465252,0.890625,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,10.0,16.0,361.7779126213592,3.5419734069741575e-24,AAA+ P-loop alpha1 module,True,assigned_too_few_test_positives +12033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic signal-anchor helices,False,no_term_above_threshold +12034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical interface regions,False,no_term_above_threshold +12035,59224,37.665268,0.91015625,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.91015625,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9986666666666666,0.8222789115646256,0.0031014621178555605,0.8571428571428571,265.12621477162287,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Hydrolase N-terminal targeting segments,True,assigned_and_evaluated +12036,85669,20.493206,0.96972656,3.40.50.2300,gene3d,85669,3.40.50.2300,0.96972656,62,gene3d,3.40.50.2300,gene3d:gene3d:3.40.50.2300,5.0,2257.0,0.8908081705150978,0.5021097326835032,0.002215330084182543,0.4,226.65233333333336,16.0,17.0,239.80291603821018,2.0288315103653354e-37,Clamshell ligand-binding β-strands,True,assigned_and_evaluated +12037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich low-complexity regions,False,no_term_above_threshold +12038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TrpRS Rossmann-core window,False,no_term_above_threshold +12039,46078,18.309856,0.85058594,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.8173828,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,0.0,15.0,0.0,1.0,Active-site pocket loops,True,assigned_too_few_test_positives +12040,88161,47.016075,0.6152344,Transmembrane helix,keyword,88161,Transmembrane helix,0.6152344,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6031181576477949,0.3433537514423645,0.1847585290208241,0.2446043165467626,1.8583918873031577,18.0,18.0,5.4274920345926265,1.3381271936351714e-13,Transmembrane helix N-cap,True,assigned_and_evaluated +12041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic glycan-binding groove,False,no_term_above_threshold +12042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disorder and structural patches,False,no_term_above_threshold +12043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like C-terminal strand-helix motif,False,no_term_above_threshold +12044,59229,26.250046,0.9584961,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9584961,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8772430033863998,0.6600320140595893,0.0101905183872397,0.7391304347826086,64.76922851010839,10.0,11.0,96.61481121374169,1.4079593487523914e-19,Rossmann glycine-rich cofactor loop,True,assigned_and_evaluated +12045,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide phosphate-binding subdomain,False,no_term_above_threshold +12046,61392,24.333782,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.6113281,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9995555555555555,0.7545918367346939,0.0031014621178555605,1.0,243.30196793002915,11.0,17.0,108.36599471249174,9.376806664187162e-21,Solenoid repeat scaffold signature,True,assigned_and_evaluated +12047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic interaction surfaces,False,no_term_above_threshold +12048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic secondary-structure context marker,False,no_term_above_threshold +12049,88178,15.662031,0.63916016,Ubiquinone,keyword,6543,NADH:ubiquinone reductase (H+-translocating),0.63427734,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,0.0,17.0,0.0,1.0,Membrane glycosyltransferase TM helices,True,assigned_too_few_test_positives +12050,45553,19.911842,0.9736328,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.9379883,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,11.0,18.0,418.79374201788,3.427950356257294e-27,Nuclease C-terminal interaction modules,True,assigned_too_few_test_positives +12051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-flanking recognition loops,False,no_term_above_threshold +12052,87732,16.709597,0.7705078,Lipid transport,keyword,87732,Lipid transport,0.7705078,44,keywords,Lipid transport,keyword:keywords:Lipid transport,,,,,,,,2.0,19.0,26.258973794318432,0.0045321240346264495,Membrane-facing extracellular ectodomains,True,assigned_too_few_test_positives +12053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical nucleic acid-binding regions,False,no_term_above_threshold +12054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization interfaces,False,no_term_above_threshold +12055,64148,34.822792,0.984375,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.93603516,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9925215182728941,0.4873986344925089,0.008418254319893664,0.3684210526315789,57.897827265768036,17.0,18.0,84.04286898839138,4.532633736703075e-32,Winged-helix β-hairpin wing,True,assigned_and_evaluated +12056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-flanking extramembrane regions,False,no_term_above_threshold +12057,36535,22.89625,0.9614258,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8930664,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9481753449043168,0.8904430660168364,0.004430660168365086,0.9,200.97299999999998,12.0,12.0,89.79066265060241,9.608590434204234e-24,Kinase αC helix motif,True,assigned_and_evaluated +12058,-1,,,,,-1,,,0,,,,,,,,,,,,,,,First ordered N-terminal module,False,no_term_above_threshold +12059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane ion transport helices,False,no_term_above_threshold +12060,37282,17.875431,0.8984375,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.85253906,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,0.0,15.0,0.0,1.0,Exposed solenoid-repeat interaction surfaces,True,assigned_too_few_test_positives +12061,36449,17.869177,1.0,EamA domain,interpro,64026,MFS transporter superfamily,0.76123047,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,11.0,19.0,616.3825187969925,4.743915465033225e-29,Alpha-helical transmembrane segments,True,assigned_too_few_test_positives +12062,85672,17.033743,0.60058594,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.60058594,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5627470108559708,0.06595319874008398,0.01595037660611431,,4.134899154343599,15.0,17.0,35.30655349388078,3.0965937321674366e-22,Accessory nucleic acid-binding domains,True,assigned_and_evaluated +12063,49116,16.51639,0.80322266,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.80322266,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9942273534635879,0.2420221934927817,0.002215330084182543,,109.24881814264167,0.0,17.0,0.0,1.0,Small GTPase regulatory regions,True,assigned_and_evaluated +12064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory beta-strand segments,False,no_term_above_threshold +12065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged IDRs and exposed helices,False,no_term_above_threshold +12066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hairpins and coiled-coils,False,no_term_above_threshold +12067,28025,19.39908,0.9404297,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6948242,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9139641640752258,0.5047720703458408,0.002658396101019052,0.6666666666666666,189.87842712842712,16.0,16.0,271.00454545454545,5.155285316227781e-39,TRAFAC GTPase Switch II/interswitch,True,assigned_and_evaluated +12068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M3 post-HEXXH SILMEHF subregion,False,no_term_above_threshold +12069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH C-terminal catalytic helix,False,no_term_above_threshold +12070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal/proton-coordinating regions,False,no_term_above_threshold +12071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asp-box beta-propeller active-site motif,False,no_term_above_threshold +12072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal PIxRLINAxL helix,False,no_term_above_threshold +12073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature surface-exposed segments,False,no_term_above_threshold +12074,36668,17.173431,0.98583984,AMP-dependent synthetase/ligase domain,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.89160156,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,17.0,17.0,532.3303571428571,3.538165212749175e-46,ANL A10 adenylation loop,True,assigned_too_few_test_positives +12075,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic N-terminal scaffolds,False,no_term_above_threshold +12076,36010,18.51461,0.9067383,Alpha/beta hydrolase fold-1,interpro,85656,alpha/beta hydrolase,0.68310547,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,14.0,14.0,509.58119658119665,3.846657256761731e-38,AB-hydrolase lid/cap gate,True,assigned_too_few_test_positives +12077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAST-rich Rossmann helix-starts,False,no_term_above_threshold +12078,85364,30.640755,0.88964844,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.88964844,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,Extracytoplasmic ligand-binding loops,True,assigned_too_few_test_positives +12079,64058,30.277927,0.99072266,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.96484375,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.999044646837781,0.9467252017085905,0.006202924235711121,0.9285714285714286,152.6256271611635,13.0,14.0,105.85536738596012,6.816532097432767e-26,SDR Rossmann cofactor binding helix,True,assigned_and_evaluated +12080,36010,16.907804,0.9140625,Alpha/beta hydrolase fold-1,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8144531,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,17.0,0.0,1.0,PAS/PAS-like sensory domains,True,assigned_too_few_test_positives +12081,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic terminal regulatory/accessory modules,False,no_term_above_threshold +12082,37894,22.046827,0.9765625,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.92578125,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Rossmann NAD(P) cofactor helix,True,assigned_too_few_test_positives +12083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter transmembrane helix bundle,False,no_term_above_threshold +12084,36091,22.11864,0.9892578,GNAT domain,interpro,85712,3.40.630.30,0.98291016,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,19.0,357.48767488341105,5.778092987514223e-45,GNAT active-site helix-loop,True,assigned_too_few_test_positives +12085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic N-terminal PIN/PINc submotif,False,no_term_above_threshold +12086,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Loop hotspots within domains,False,no_term_above_threshold +12087,49230,30.56212,0.9213867,Acyl-CoA N-acyltransferase,interpro,49230,Acyl-CoA N-acyltransferase,0.9213867,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,15.0,18.0,234.35927672955975,4.336838746236214e-34,Acyltransferase donor-binding cleft,True,assigned_too_few_test_positives +12088,4066,19.77577,0.8105469,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.8105469,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.7931616341030197,0.19612422727176826,0.002215330084182543,0.4,88.5304761904762,2.0,18.0,79.81392235609103,0.0005176719304714234,Charge-rich C-terminal interaction surfaces,True,assigned_and_evaluated +12089,36449,19.628832,0.9995117,EamA domain,interpro,36449,EamA domain,0.9995117,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,13.0,18.0,768.921626984127,4.6836628481461014e-36,Juxtamembrane helix–loop interface signature,True,assigned_too_few_test_positives +12090,81349,16.208836,0.9873047,1.10.287.1490,gene3d,87326,Coiled coil,0.65625,31,gene3d,1.10.287.1490,gene3d:gene3d:1.10.287.1490,,,,,,,,10.0,19.0,189.03297400126823,5.13055779678576e-21,Coiled-coil heptad register,True,assigned_too_few_test_positives +12091,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease/toxin domain marker,False,no_term_above_threshold +12092,61392,24.007147,0.82910156,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.82910156,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.8532063492063493,0.304807700661124,0.0031014621178555605,0.14285714285714285,98.27871148459384,11.0,11.0,167.4747191011236,8.831826373930315e-25,Innate immune LRR/TIR interfaces,True,assigned_and_evaluated +12093,29104,16.153185,0.6958008,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.6958008,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,12.0,12.0,428.9280575539568,6.72820626905281e-32,TM helix-loop-helix hairpins,True,assigned_too_few_test_positives +12094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-caps and coiled-coils,False,no_term_above_threshold +12095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal substrate-binding cleft,False,no_term_above_threshold +12096,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site entrance elements,False,no_term_above_threshold +12097,36115,23.867052,0.93603516,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9135742,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,11.0,0.0,1.0,D/E-centered beta-alpha junction motif,True,assigned_too_few_test_positives +12098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-centered hydrophobic microdomain,False,no_term_above_threshold +12099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical scaffolds,False,no_term_above_threshold +12100,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature catalytic and regulatory domains,False,no_term_above_threshold +12101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SecA Arg-Asp-rich motif,False,no_term_above_threshold +12102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transcription factor DNA-binding domains,False,no_term_above_threshold +12103,85672,17.885149,0.6147461,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61376953,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6035319425684126,0.08333637992826949,0.01595037660611431,0.1111111111111111,5.224728041614007,14.0,18.0,31.122073079791203,2.483170696855038e-19,Upstream primase DNA-binding subdomain,True,assigned_and_evaluated +12104,72011,17.218704,0.953125,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.88427734,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,16.0,0.0,1.0,Aromatic Gly/Pro gating loops,True,assigned_too_few_test_positives +12105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfatase C-terminal hydrophilic appendages,False,no_term_above_threshold +12106,-1,,,,,-1,,,0,,,,,,,,,,,,,,,bZIP IDR transactivation domains,False,no_term_above_threshold +12107,82029,22.496103,0.99902344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69921875,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,Transmembrane helix exit caps,True,assigned_too_few_test_positives +12108,87317,19.113298,0.70751953,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.70751953,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.6107624944221329,0.03410780555860024,0.007089056269384138,,4.811332321610046,3.0,18.0,14.074834749763928,0.0020692165904108834,Extracellular disordered PTM-rich regions,True,assigned_and_evaluated +12109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich low-complexity IDRs,False,no_term_above_threshold +12110,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1 signal-anchor interface motifs,False,no_term_above_threshold +12111,87326,40.580814,0.8046875,Coiled coil,keyword,87326,Coiled coil,0.8046875,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8366951366142876,0.38101979843343237,0.03943287549844927,0.38202247191011235,9.662490843418617,18.0,19.0,11.943973912366028,6.647492796621427e-19,Coiled-coil heptad register,True,assigned_and_evaluated +12112,81858,18.361929,0.94091797,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6567383,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,5.0,14.0,93.39129072681705,3.1206033936448607e-09,Extracellular helix-loop-helix junctions,True,assigned_too_few_test_positives +12113,64058,20.400898,0.9316406,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8330078,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9791096108528119,0.6356664708680612,0.006202924235711121,0.5714285714285714,102.47851605351529,2.0,15.0,15.199745060548118,0.012797213476436363,FAD/NAD Rossmann loops,True,assigned_and_evaluated +12114,84152,20.119608,0.8100586,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8100586,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,7.0,13.0,302.8642960812772,1.874114646300197e-16,Pol III alpha conserved segment,True,assigned_too_few_test_positives +12115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MRH glycoprotein quality-control lectins,False,no_term_above_threshold +12116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short β-strands flanking functional sites,False,no_term_above_threshold +12117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended IDRs and alpha-solenoids,False,no_term_above_threshold +12118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Thr-rich β-hairpin loop,False,no_term_above_threshold +12119,36876,15.830029,0.89404297,Cytochrome P450,interpro,36876,Cytochrome P450,0.89404297,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9957493080268881,0.6846139099762287,0.003987594151528578,0.6666666666666666,171.68595497959427,0.0,13.0,0.0,1.0,CENP-V/GFA C-terminal motif,True,assigned_and_evaluated +12120,37020,16.712524,0.9980469,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98046875,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,18.0,771.3523592085236,3.565291332168778e-48,Glycosyltransferase donor-binding helix,True,assigned_too_few_test_positives +12121,36886,29.513723,0.9926758,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9926758,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9299688750555802,0.16297229048659806,0.003544528134692069,,45.97855745353148,0.0,13.0,0.0,1.0,Gly/Ala-rich β-solenoid repeats,True,assigned_and_evaluated +12122,87586,18.72499,0.69873047,Host membrane,keyword,88161,Transmembrane helix,0.6508789,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7869978086194301,0.2061237556880627,0.01639344262295082,,12.573549096971824,4.0,19.0,13.59890517192222,0.0003325917773671762,C-terminal anchor TM detector,True,assigned_and_evaluated +12123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity activation domains,False,no_term_above_threshold +12124,2772,16.149899,0.9140625,2.4.-.-,ec,85664,Glycogen Phosphorylase B;,0.86621094,46,ec,2.4.-.-,ec:ec:2.4.-.-,,,,,,,,0.0,17.0,0.0,1.0,REC alpha2 helix motif,True,assigned_too_few_test_positives +12125,64146,30.018417,0.84228516,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.84228516,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8015731229219393,0.2825043163518689,0.007975188303057155,0.2777777777777778,35.42290233367601,15.0,18.0,55.69973841554559,8.80269689830672e-25,Short amphipathic helix caps,True,assigned_and_evaluated +12126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal disordered low-complexity tails,False,no_term_above_threshold +12127,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-adjacent interaction alpha-helices,False,no_term_above_threshold +12128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-handling membrane acyltransferases,False,no_term_above_threshold +12129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-binding catalytic hydrophobe activation,False,no_term_above_threshold +12130,37894,16.003883,0.72558594,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.72558594,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Helix-start beta-alpha motif,True,assigned_too_few_test_positives +12131,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2/GRAM/MNNL membrane-docking domains,False,no_term_above_threshold +12132,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NACHT WHD hydrophobic helices,False,no_term_above_threshold +12133,88160,15.758487,0.74072266,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6508789,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,20.0,20.0,289.42233009708735,1.3081407774040853e-48,Extracellular transmembrane loop segments,True,assigned_too_few_test_positives +12134,33778,16.774248,0.78808594,"2 iron, 2 sulfur cluster binding",go_mf,87681,Iron-sulfur,0.68603516,27,go,GO:0051537,go_mf:go:GO:0051537,,,,,,,,12.0,12.0,346.6337209302326,8.844732296002852e-31,N-terminal Fe–S redox module,True,assigned_too_few_test_positives +12135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-adjacent scaffold loops,False,no_term_above_threshold +12136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD-fold flank-biased activation,False,no_term_above_threshold +12137,87108,27.29138,0.84716797,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.84033203,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.7711546065638594,0.13695744925253123,0.003987594151528578,,34.345884773662554,0.0,14.0,0.0,1.0,LRR N-terminal capping segments,True,assigned_and_evaluated +12138,27918,16.663399,0.6147461,DNA-binding transcription factor activity,go_mf,27918,DNA-binding transcription factor activity,0.6147461,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.5871667092597326,0.04569713187980167,0.00930438635356668,,4.911353650129161,1.0,13.0,2.8468223272692548,0.46890757045586634,DHp dimerization coiled-coil helix,True,assigned_and_evaluated +12139,88161,62.43794,0.6948242,Transmembrane helix,keyword,88161,Transmembrane helix,0.6948242,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7720160827859452,0.6109289909336844,0.1847585290208241,0.6354916067146283,3.306634850209414,18.0,19.0,5.141834559087751,2.044185969474243e-12,Short charged cytosolic PPI motifs,True,assigned_and_evaluated +12140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cleft-lining hinge segments,False,no_term_above_threshold +12141,37576,22.860727,0.9824219,"Zinc finger, PHD-type",interpro,37576,"Zinc finger, PHD-type",0.9824219,31,ip,IPR001965,interpro:ip:IPR001965,,,,,,,,0.0,15.0,0.0,1.0,Acidic beta-alpha catalytic loop,True,assigned_too_few_test_positives +12142,87489,26.334631,0.95410156,GPI-anchor,keyword,88058,Signal,0.61865234,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9239047619047619,0.554014494588265,0.0031014621178555605,0.8571428571428571,178.6301020408163,17.0,18.0,139.03388203017832,9.649068030568467e-36,C-terminal GPI anchor signal,True,assigned_and_evaluated +12143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small/polar terminal segments,False,no_term_above_threshold +12144,59211,19.287182,0.71533203,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.71533203,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.8989695340501793,0.8022153300841826,0.011076650420912717,0.8,72.42399999999999,17.0,17.0,244.34836065573774,1.3495568203358695e-40,MobA-like NTase core module,True,assigned_and_evaluated +12145,63774,23.606834,0.9946289,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9741211,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,16.0,16.0,182.88650306748465,2.5097298588801855e-36,RNA-protein low-complexity termini,True,assigned_too_few_test_positives +12146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic/cleavage-fusion linear segments,False,no_term_above_threshold +12147,87149,23.43464,0.68652344,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.68652344,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7680253797346663,0.1368243762663889,0.012405848471422242,,11.029022044044277,0.0,19.0,0.0,1.0,Amphipathic membrane-active helices,True,assigned_and_evaluated +12148,87326,21.356012,0.6142578,Coiled coil,keyword,87326,Coiled coil,0.6142578,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6066612421742195,0.10384005827689474,0.03943287549844927,0.011235955056179775,2.6333372082129376,11.0,18.0,7.704600455816358,2.9116703408912692e-08,Heptad-repeat coiled-coils,True,assigned_and_evaluated +12149,82029,27.731815,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9946289,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Aromatic TM helix C-terminal caps,True,assigned_too_few_test_positives +12150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Two-component sensor kinase linker hotspot,False,no_term_above_threshold +12151,87970,16.207838,0.82958984,Protein phosphatase,keyword,87970,Protein phosphatase,0.82958984,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,1.0,13.0,22.15570419918246,0.07308382171924163,Asparagine synthetase ATP-binding lobe,True,assigned_too_few_test_positives +12152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal glycine-rich catalytic loops,False,no_term_above_threshold +12153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended cytosolic helical scaffolds,False,no_term_above_threshold +12154,81799,20.026031,0.8901367,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6118164,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,7.0,9.0,450.2125134843581,3.3312555812926716e-18,Post‑Walker A coupling loop,True,assigned_too_few_test_positives +12155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage viral structural C-terminal helix,False,no_term_above_threshold +12156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Roadblock/longin adaptor activation,False,no_term_above_threshold +12157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site phosphate-binding loops,False,no_term_above_threshold +12158,69093,16.6822,0.73095703,"ANL, N-terminal domain",interpro,69093,"ANL, N-terminal domain",0.73095703,40,ip,IPR042099,interpro:ip:IPR042099,,,,,,,,0.0,16.0,0.0,1.0,Active-site pyrophosphate-binding loops,True,assigned_too_few_test_positives +12159,36535,18.998302,0.9165039,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8886719,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9421450823319982,0.22346794142374457,0.004430660168365086,,50.43671437933915,0.0,15.0,0.0,1.0,Histidine kinase CA-domain helix,True,assigned_and_evaluated +12160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Activated C-terminal capping segments,False,no_term_above_threshold +12161,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylated extracytoplasmic ectodomains,False,no_term_above_threshold +12162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-strand surface clusters,False,no_term_above_threshold +12163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral binding helices and linkers,False,no_term_above_threshold +12164,85682,38.872105,0.8725586,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8725586,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9564157706093189,0.7399171417927529,0.011076650420912717,0.84,66.79971956104973,16.0,16.0,102.26586620926243,2.472580145272991e-32,Rossmann NAD(P)-binding β-loop-α motif,True,assigned_and_evaluated +12165,87586,18.88716,0.71972656,Host membrane,keyword,88161,Transmembrane helix,0.7109375,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.8779461894326758,0.14794866318358935,0.01639344262295082,,9.02486845419895,0.0,18.0,0.0,1.0,Membrane-proximal cytoplasmic gating segments,True,assigned_and_evaluated +12166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nontransmembrane extracytosolic domains,False,no_term_above_threshold +12167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PheRS β B5 Mg2+ motif,False,no_term_above_threshold +12168,8138,15.788578,0.6064453,translation,go_bp,27932,structural constituent of ribosome,0.6044922,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.6658503566082593,0.24956957741904134,0.018165706690296855,0.3170731707317073,13.738500883775032,0.0,9.0,0.0,1.0,Basic nucleic acid-binding patches,True,assigned_and_evaluated +12169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P-rich disordered repeats,False,no_term_above_threshold +12170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH13 RG[IV]DNxxYY motif,False,no_term_above_threshold +12171,38873,21.144066,0.9863281,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9482422,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9992007104795737,0.7933333333333332,0.002215330084182543,0.8,358.11066666666665,17.0,17.0,171.32471264367817,4.863559959424677e-38,P-loop Walker A S/T,True,assigned_and_evaluated +12172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NadD active-site Lys loop,False,no_term_above_threshold +12173,36104,32.062855,0.9819336,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9819336,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,C-family polymerase helical core,True,assigned_too_few_test_positives +12174,64596,35.22985,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,1.0,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,12.0,12.0,614.6494845360825,8.092433897031415e-34,Metallo-β-lactamase fold domain,True,assigned_too_few_test_positives +12175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal β-rich recognition modules,False,no_term_above_threshold +12176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UMP kinase TRxNA helix,False,no_term_above_threshold +12177,47529,23.66683,0.9033203,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9033203,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.946731369924141,0.3005799493592831,0.007089056269384138,0.0625,42.40055910649387,10.0,16.0,48.33090142671855,2.1698167408791997e-15,GH3 C-terminal acidic motif,True,assigned_and_evaluated +12178,-1,,,,,-1,,,0,,,,,,,,,,,,,,,START-like termini and linkers,False,no_term_above_threshold +12179,64475,16.03152,0.85498047,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.83447266,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.8824386397915809,0.621866993588305,0.0057598582188746125,0.6923076923076923,107.96567727144648,0.0,12.0,0.0,1.0,Post-signal PBP clamshell hinge,True,assigned_and_evaluated +12180,64058,25.469315,0.9604492,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.94433594,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9816572192853958,0.1809320522351656,0.006202924235711121,,29.168831563912054,6.0,13.0,52.614502132666566,1.4878219757400116e-09,Post-motif I Ala patch,True,assigned_and_evaluated +12181,87108,15.748842,0.86816406,ANK repeat,keyword,88009,Repeat,0.73046875,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8727016607354685,0.030740119788491796,0.003987594151528578,,7.708938929180666,0.0,19.0,0.0,1.0,Cysteine-rich repeat microdomains,True,assigned_and_evaluated +12182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ApbE FAD-adjacent internal helix,False,no_term_above_threshold +12183,50338,17.139853,0.84228516,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.7988281,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,Terminal stop-transfer anchor-cap,True,assigned_too_few_test_positives +12184,49116,19.987999,0.87646484,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.87646484,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9923623445825932,0.1700174825174825,0.002215330084182543,,76.7458916083916,18.0,19.0,82.45701114099116,8.733515581581327e-34,Acidic S/T-rich IDR linkers,True,assigned_and_evaluated +12185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHp helix +2 hydrophobic face,False,no_term_above_threshold +12186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-centered interface helices,False,no_term_above_threshold +12187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Allosteric connector helices,False,no_term_above_threshold +12188,45324,18.842653,0.93359375,Pectin lyase fold/virulence factor,interpro,49236,C-type lectin fold,0.8964844,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.49156305506216696,0.002215330084182543,0.002215330084182543,,1.0,15.0,15.0,546.9816513761467,3.1549135532889026e-41,Short extracellular xAPhp motif,True,assigned_and_evaluated +12189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NAT active-site beta-strand signature,False,no_term_above_threshold +12190,63960,31.636528,0.86865234,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.86865234,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,16.0,16.0,193.57467532467533,1.0288461071936617e-36,N-terminal glycine-rich FAD-binding loop,True,assigned_too_few_test_positives +12191,64148,33.631866,0.8959961,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8339844,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9405954564695924,0.5560079790568757,0.008418254319893664,0.3684210526315789,66.04789519638781,15.0,16.0,83.42490671641791,2.688797228425055e-28,Post-HTH linker helix,True,assigned_and_evaluated +12192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase-flanking charged IDRs,False,no_term_above_threshold +12193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil charged tail boundary,False,no_term_above_threshold +12194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Palmitoylation-enriched cytosolic segments,False,no_term_above_threshold +12195,25169,17.591484,0.8935547,pilus,go_cc,47529,Immunoglobulin-like fold,0.8364258,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9841030195381884,0.08701612135734979,0.002215330084182543,,39.279077180707695,0.0,16.0,0.0,1.0,Core hydrophobic beta strands,True,assigned_and_evaluated +12196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-SLiM disordered regulatory regions,False,no_term_above_threshold +12197,82029,21.804941,0.98583984,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.64160156,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,6.0,16.0,70.52957413249212,3.4430525096726335e-10,TM1 helix-start hydrophobic patches,True,assigned_too_few_test_positives +12198,86130,19.486084,0.94189453,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.93896484,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9267301587301586,0.6762934061528909,0.0031014621178555605,0.8571428571428571,218.05631681243926,19.0,19.0,240.4072580645161,5.760697025477574e-45,Gal4-like helical regulatory core,True,assigned_and_evaluated +12199,84152,27.655704,0.9848633,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9848633,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,Metal-dependent hydrolase metallocenter,True,assigned_too_few_test_positives +12200,15821,17.074238,0.6870117,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6870117,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,11.0,0.0,1.0,Extracytoplasmic copper redox domains,True,assigned_too_few_test_positives +12201,38317,18.40737,0.91259766,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.91259766,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.656031746031746,0.008141702549927845,0.0031014621178555605,,2.6251175221695924,0.0,15.0,0.0,1.0,NuoG/NDUFS1 glycine-rich loop,True,assigned_and_evaluated +12202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase terminal interaction scaffolds,False,no_term_above_threshold +12203,58239,24.843014,0.6582031,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6582031,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.5918583671628327,0.10660914166196385,0.017722640673460344,0.15,6.0154208182763105,15.0,16.0,33.61075616355983,1.95430617609731e-22,ATPase-core selective activation,True,assigned_and_evaluated +12204,64475,16.691519,0.9941406,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.96240234,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,1.0,1.0,0.0057598582188746125,1.0,173.6153846153846,6.0,19.0,168.10432330827066,2.240702768637898e-12,Laminin coiled-coil and EGF repeats,True,assigned_and_evaluated +12205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-to-C-terminal soluble segments,False,no_term_above_threshold +12206,86130,24.615463,0.91308594,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9116211,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9997460317460318,0.9325396825396823,0.0031014621178555605,1.0,300.67743764172326,17.0,18.0,227.0512992831541,2.6614781294915923e-39,Fungal Zn2Cys6 TF hydrophobic peaks,True,assigned_and_evaluated +12207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible phosphate-binding patches,False,no_term_above_threshold +12208,88009,23.091581,0.65283203,Repeat,keyword,88058,Signal,0.60302734,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7385302926130074,0.21268971708767292,0.07266282676118742,0.018292682926829267,2.9270773869931572,12.0,19.0,5.599311289375856,1.9359993500844814e-07,Modular domain entry motifs,True,assigned_and_evaluated +12209,64507,37.4955,0.9941406,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9941406,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9986160537761961,0.8821895424836601,0.003987594151528578,0.8888888888888888,221.23353304284677,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat capping residues,True,assigned_and_evaluated +12210,63774,20.533289,0.98291016,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.97998047,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,17.0,0.0,1.0,C-terminal acidic PG/SP motifs,True,assigned_too_few_test_positives +12211,69990,16.768438,0.9199219,DNA/RNA polymerase superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6298828,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.6302222222222222,0.12126294913180158,0.0031014621178555605,0.2857142857142857,39.09863945578231,0.0,15.0,0.0,1.0,GGDEF/palm-domain catalytic loops,True,assigned_and_evaluated +12212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global long-protein activation excluding transmembranes,False,no_term_above_threshold +12213,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Assembly scaffolds and low-complexity linkers,False,no_term_above_threshold +12214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Photolyase/Cryptochrome C-terminal DNA-binding motif,False,no_term_above_threshold +12215,45290,23.719082,0.7397461,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7397461,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6891197038255862,0.24173616106316712,0.0057598582188746125,0.23076923076923078,41.96911657842832,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Hydrophobic C-terminal kinase segment,True,assigned_and_evaluated +12216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteasome beta conserved motif,False,no_term_above_threshold +12217,31094,16.357643,0.9951172,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.82373047,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9969292389853138,0.517967032967033,0.004430660168365086,0.9,116.90515934065934,0.0,17.0,0.0,1.0,SDR C-terminal strand-helix junction,True,assigned_and_evaluated +12218,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aminotransferase N-terminal interface segment,False,no_term_above_threshold +12219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease TM boundary motif,False,no_term_above_threshold +12220,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic transmembrane helices,False,no_term_above_threshold +12221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme surfaces and regulators,False,no_term_above_threshold +12222,50763,18.83203,0.97314453,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.94433594,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,17.0,0.0,1.0,Helical effectors and catalytic flanks,True,assigned_too_few_test_positives +12223,48880,20.045444,0.92041016,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.92041016,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,11.0,11.0,484.7235772357723,6.820886659830516e-30,Conserved N-terminal sugar aminotransferase segment,True,assigned_too_few_test_positives +12224,36091,25.546667,0.9892578,GNAT domain,interpro,85712,3.40.630.30,0.97558594,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,20.0,20.0,377.3481012658228,1.1067828780026621e-50,GNAT N-terminal gating loop,True,assigned_too_few_test_positives +12225,31094,16.258732,0.97558594,phosphopantetheine binding,go_mf,50338,"GPCR, rhodopsin-like, 7TM",0.86816406,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9964396973742768,0.37565956918898097,0.004430660168365086,0.9,84.78636476595301,0.0,17.0,0.0,1.0,Multi-pass transporter TM helix,True,assigned_and_evaluated +12226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat scaffolds and translocation tails,False,no_term_above_threshold +12227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tryptophan residue detector,False,no_term_above_threshold +12228,36091,25.6503,0.9995117,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.99121094,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,15.0,15.0,377.3481012658228,8.377022726305081e-39,Acyltransferase donor-binding loop,True,assigned_too_few_test_positives +12229,47529,17.115963,0.8833008,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8833008,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9467592592592593,0.07508200670136264,0.007089056269384138,,10.591255570310969,0.0,19.0,0.0,1.0,VIT beta-sandwich domain,True,assigned_and_evaluated +12230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary motif detector,False,no_term_above_threshold +12231,36449,17.556562,0.8564453,EamA domain,interpro,36449,EamA domain,0.8564453,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,17.0,0.0,1.0,Helix-capping functional motifs,True,assigned_too_few_test_positives +12232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural helix–coil segment,False,no_term_above_threshold +12233,88058,87.31157,0.93115234,Signal,keyword,88058,Signal,0.93115234,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9349808050063194,0.7048973197278906,0.09127159946832078,0.9029126213592233,7.723074032164316,18.0,18.0,7.204954682779456,8.53289450276625e-16,Basic signal peptide n-region,True,assigned_and_evaluated +12234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical packing flanking cofactors,False,no_term_above_threshold +12235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane coiled-coil arms,False,no_term_above_threshold +12236,88058,78.08154,0.8828125,Signal,keyword,88058,Signal,0.8828125,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.904851055369628,0.6329073643453537,0.09127159946832078,0.8349514563106796,6.93432971518186,17.0,18.0,6.804679422625042,9.227806822550483e-14,Targeting peptide cleavage site,True,assigned_and_evaluated +12237,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Neutral ceramidase N-terminal catalytic motif,False,no_term_above_threshold +12238,50338,18.091137,0.9785156,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9404297,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,14.0,14.0,392.24342105263156,1.5430365532165164e-36,Intrinsically disordered GPCR tails,True,assigned_too_few_test_positives +12239,38317,20.997677,0.8691406,Pentatricopeptide repeat,interpro,25079,plasma membrane,0.60009766,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6622857142857143,0.00892668457745572,0.0031014621178555605,,2.878218155902508,0.0,18.0,0.0,1.0,Transmembrane boundary interfacial helices,True,assigned_and_evaluated +12240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIM-barrel active-site enrichment,False,no_term_above_threshold +12241,36115,16.744852,0.97216797,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.96240234,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,19.0,0.0,1.0,RhoGAP/DH catalytic-core sensor,True,assigned_too_few_test_positives +12242,87914,16.222559,0.6567383,Phosphoprotein,keyword,24917,nucleus,0.6425781,957,keywords,Phosphoprotein,keyword:keywords:Phosphoprotein,84.0,2257.0,0.803124931518857,0.16474628361250593,0.03721754541426672,0.011904761904761904,4.426575739445546,16.0,20.0,4.874481349003577,1.4074263690109374e-09,Disordered SLiM signaling platforms,True,assigned_and_evaluated +12243,72011,17.363146,0.9404297,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.90527344,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,N-terminal transmembrane helices,True,assigned_too_few_test_positives +12244,64507,34.572094,0.9970703,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9970703,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin repeat turn glycine,True,assigned_and_evaluated +12245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil oligomerization helices,False,no_term_above_threshold +12246,36449,17.051435,0.99365234,EamA domain,interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8666992,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,16.0,0.0,1.0,Membrane glycosylation transmembrane helices,True,assigned_too_few_test_positives +12247,87149,22.540108,0.6826172,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6826172,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7326475677754277,0.05865649915749818,0.012405848471422242,,4.728132807088335,0.0,18.0,0.0,1.0,Basic-flanked interfacial amphipathic helices,True,assigned_and_evaluated +12248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed effector-binding surface,False,no_term_above_threshold +12249,82029,24.260715,0.9995117,MFS general substrate transporter like domains,gene3d,37446,F-box domain,0.88720703,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,MFS cytoplasmic gating helices,True,assigned_too_few_test_positives +12250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered PP1 and PKA scaffolds,False,no_term_above_threshold +12251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix–loop junctions,False,no_term_above_threshold +12252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich repeat capping motifs,False,no_term_above_threshold +12253,47717,15.572498,0.87890625,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6220703,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,11.0,12.0,250.6999235474006,4.5557975492680533e-26,Motor ATPase C-terminal extensions,True,assigned_too_few_test_positives +12254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF/EAL regulatory helix,False,no_term_above_threshold +12255,83419,19.543074,0.9824219,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.97216797,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,15.0,18.0,302.9522357723577,8.93547183013231e-36,Glycan-binding beta-strand patches,True,assigned_too_few_test_positives +12256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-edge at disorder boundary,False,no_term_above_threshold +12257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-loop binding belts,False,no_term_above_threshold +12258,87276,37.789604,0.6640625,Cell membrane,keyword,88161,Transmembrane helix,0.6347656,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7729361715649863,0.4998211610433273,0.11120957022596367,0.5856573705179283,4.494407810656533,11.0,18.0,5.014458513013427,2.3363666647259754e-06,N-terminal transmembrane helix,True,assigned_and_evaluated +12259,85649,18.416279,0.6821289,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6791992,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7104725390214471,0.1238717832574514,0.0101905183872397,,12.155591948350773,4.0,12.0,36.87136672850958,5.843159578153444e-06,Nucleotide cofactor-binding α/β core,True,assigned_and_evaluated +12260,88161,26.37687,0.6401367,Transmembrane helix,keyword,88161,Transmembrane helix,0.6401367,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.692771217808362,0.3613704829637789,0.1847585290208241,0.1486810551558753,1.955906906592923,6.0,20.0,1.6282476103777879,0.2346416128217339,TM hydrophobics and conserved motifs,True,assigned_and_evaluated +12261,58239,19.031918,0.64160156,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.64160156,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6888249887235002,0.25473703562402844,0.017722640673460344,0.225,14.373537235085806,12.0,18.0,23.900982160753657,7.904675492183971e-15,Noncatalytic switch/transducer regions,True,assigned_and_evaluated +12262,36354,17.902147,0.8642578,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.85839844,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,18.0,0.0,1.0,N-terminal noncatalytic regions,True,assigned_too_few_test_positives +12263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-TM amphipathic elements and linkers,False,no_term_above_threshold +12264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane helix tail,False,no_term_above_threshold +12265,58239,15.749416,0.7128906,P-loop containing nucleoside triphosphate hydrolase,interpro,87601,Hydrolase,0.63964844,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8257949932341003,0.07589918352225947,0.017722640673460344,,4.282611430243491,1.0,15.0,2.3900982160753657,0.5403976437680915,Active-site loop residues,True,assigned_and_evaluated +12266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich strand-capping loop,False,no_term_above_threshold +12267,85364,17.964197,0.75634766,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.75634766,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,19.0,206.02684742158428,3.6533632046702945e-28,C-terminal helical bundle activation,True,assigned_too_few_test_positives +12268,85664,19.497877,0.97314453,Glycogen Phosphorylase B;,gene3d,85712,3.40.630.30,0.90966797,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Glycosyltransferase donor-binding pocket,True,assigned_too_few_test_positives +12269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop-helix junction,False,no_term_above_threshold +12270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Small-protein whole-domain activation, C-terminal Arg/Lys",False,no_term_above_threshold +12271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural helical packing segments,False,no_term_above_threshold +12272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal amphipathic packing helix,False,no_term_above_threshold +12273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic regulatory appendages,False,no_term_above_threshold +12274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Strand-edge hinge micro-motif,False,no_term_above_threshold +12275,87697,20.214886,0.87353516,Knottin,keyword,87413,Disulfide bond,0.7314453,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9785843101893598,0.26870424226879336,0.017279574656623838,,15.550396789760681,0.0,18.0,0.0,1.0,Extracellular Cys-rich ectodomains,True,assigned_and_evaluated +12276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble amphipathic alpha-helices,False,no_term_above_threshold +12277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-rich coil capping motifs,False,no_term_above_threshold +12278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KS/thiolase active-site gating loop,False,no_term_above_threshold +12279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible terminal tails and linkers,False,no_term_above_threshold +12280,36104,24.00574,0.99560547,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.99560547,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Peptidoglycan catalytic cleft helix,True,assigned_too_few_test_positives +12281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Perimembrane helix-loop-helix junctions,False,no_term_above_threshold +12282,31094,16.624043,0.94921875,phosphopantetheine binding,go_mf,88147,Toxin-antitoxin system,0.7495117,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9797952825990209,0.10289903951820192,0.004430660168365086,,23.224313219258175,0.0,17.0,0.0,1.0,Interface-binding SLiM segments,True,assigned_and_evaluated +12283,64003,25.333984,0.99902344,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.98535156,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,130.4617067833698,4.066539644609368e-38,C2H2 ZF helix C-terminus,True,assigned_and_evaluated +12284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal helical linkers,False,no_term_above_threshold +12285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C transmembrane donor core,False,no_term_above_threshold +12286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop Walker A NTPase core,False,no_term_above_threshold +12287,37020,18.075617,0.9975586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,17.0,768.6833199033038,1.7917833648140597e-45,GT-B donor-adjacent hydrophobic loop,True,assigned_too_few_test_positives +12288,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protease catalytic loops,False,no_term_above_threshold +12289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prenyltransferase pre-DDXXD gating helix,False,no_term_above_threshold +12290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical-boundary basic tails and linkers,False,no_term_above_threshold +12291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA polymerase-exonuclease core,False,no_term_above_threshold +12292,64016,46.522835,0.98535156,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.98535156,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9987619047619047,0.7537414965986395,0.0031014621178555605,0.7142857142857143,243.02779397473276,14.0,14.0,221.63940520446096,4.672734293621056e-33,Noncatalytic beta-to-alpha interface helix,True,assigned_and_evaluated +12293,82029,27.907766,0.99902344,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.98583984,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,18.0,188.0788643533123,6.824310871704072e-41,Transporter TM-loop gating motifs,True,assigned_too_few_test_positives +12294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Envelope enzyme catalytic cores,False,no_term_above_threshold +12295,45324,19.096579,0.93066406,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.93066406,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9840586145648312,0.07343582996528407,0.002215330084182543,,33.14893364632923,14.0,16.0,478.60894495412845,1.374908525618535e-36,Extracellular N-terminal stem,True,assigned_and_evaluated +12296,85364,17.606298,0.70410156,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.70410156,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,4.0,19.0,63.39287612971823,8.528991916005691e-07,TRAP/ABC SBP binding hotspot,True,assigned_too_few_test_positives +12297,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory-pathway anion-processing alpha/beta cores,False,no_term_above_threshold +12298,85364,17.52996,0.84375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.84375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,SBP C-terminal aromatic clamp,True,assigned_too_few_test_positives +12299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-lactamase-like N-terminal core activation,False,no_term_above_threshold +12300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP PP/PYR active-site loops,False,no_term_above_threshold +12301,85364,18.270391,0.93359375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.93359375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,2.0,11.0,54.7483930211203,0.0010476912067103779,Post-signal N-terminal ectodomain,True,assigned_too_few_test_positives +12302,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended acidic interaction surfaces,False,no_term_above_threshold +12303,39958,19.693432,0.96972656,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.96972656,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9790833703539168,0.06652986174623973,0.002658396101019052,,25.02631632687718,0.0,14.0,0.0,1.0,SDR YXXXK catalytic helix,True,assigned_and_evaluated +12304,85672,19.48944,0.61279297,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6088867,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.5774926209415178,0.06508331782274837,0.01595037660611431,0.027777777777777776,4.080362453498419,10.0,10.0,40.01409395973155,2.2135838633896868e-16,N-terminal accessory targeting segments,True,assigned_and_evaluated +12305,81858,20.7152,0.94921875,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6479492,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Multi-pass transmembrane helices,True,assigned_too_few_test_positives +12306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic terminal helices/tails,False,no_term_above_threshold +12307,31094,16.687826,0.9941406,phosphopantetheine binding,go_mf,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9978415665331553,0.6356927620546545,0.004430660168365086,0.7,143.47585639573555,13.0,14.0,659.0756802721089,2.5820292060120413e-36,Acyl-handling amphipathic helices,True,assigned_and_evaluated +12308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal and accessory activation,False,no_term_above_threshold +12309,6543,15.629253,0.73535156,NADH:ubiquinone reductase (H+-translocating),ec,88161,Transmembrane helix,0.6088867,41,ec,7.1.1.2,ec:ec:7.1.1.2,,,,,,,,0.0,13.0,0.0,1.0,Interhelical membrane-interface segments,True,assigned_too_few_test_positives +12310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL ATPase switch/hinge linker,False,no_term_above_threshold +12311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic β-strands,False,no_term_above_threshold +12312,85672,36.201595,0.9633789,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9614258,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9495847716243935,0.3821097328286757,0.01595037660611431,0.6388888888888888,23.95615741650892,14.0,17.0,32.952783260955385,5.732262127139585e-20,Pre-loop beta-strand start preference,True,assigned_and_evaluated +12313,85649,33.009617,0.95996094,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9506836,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8849597135183527,0.5486937382239158,0.0101905183872397,0.7391304347826086,53.843555094407726,0.0,14.0,0.0,1.0,HATPase_c C-terminal beta-strand,True,assigned_and_evaluated +12314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral secondary structure linkers,False,no_term_above_threshold +12315,87162,20.288776,0.6904297,Antimicrobial,keyword,88058,Signal,0.60791016,669,keywords,Antimicrobial,keyword:keywords:Antimicrobial,56.0,2257.0,0.7859414551827092,0.17974160163595165,0.024811696942844484,,7.244228480220409,0.0,13.0,0.0,1.0,Mature secretory lumenal domains,True,assigned_and_evaluated +12316,36354,17.904846,0.7675781,RNA recognition motif domain,interpro,36354,RNA recognition motif domain,0.7675781,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,19.0,0.0,1.0,Sensory domain output edge,True,assigned_too_few_test_positives +12317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-rich signal-proximal ectodomain,False,no_term_above_threshold +12318,25014,15.892437,0.6933594,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.68847656,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.5697569756975698,0.023480986897181623,0.015507310589277802,,1.514188212198255,1.0,20.0,1.8424289245982697,0.6593733904478983,Late transmembrane alpha helices,True,assigned_and_evaluated +12319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal pre-motor scaffolds,False,no_term_above_threshold +12320,48880,20.352669,1.0,"Pyridoxal phosphate-dependent transferase, major domain",interpro,87986,Pyridoxal phosphate,0.8222656,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,18.0,18.0,484.7235772357723,5.774267819403017e-48,PLP phosphate binding loop helix,True,assigned_too_few_test_positives +12321,59224,16.0967,0.89746094,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77197266,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9326031746031745,0.028677647570864318,0.0031014621178555605,,9.246492938205824,0.0,15.0,0.0,1.0,Hydrophobic alpha-helical segments,True,assigned_and_evaluated +12322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic extracellular glycan-binding regions,False,no_term_above_threshold +12323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-strand segments,False,no_term_above_threshold +12324,88161,63.58312,0.7324219,Transmembrane helix,keyword,88159,Transmembrane,0.7285156,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.8019888437076426,0.6194245624248755,0.1847585290208241,0.6834532374100719,3.352616876242072,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Positive-inside juxtamembrane segment,True,assigned_and_evaluated +12325,52236,22.595385,0.99902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99658203,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,15.0,223.29962546816478,2.087522942442783e-35,TPR interhelical A–B turn,True,assigned_too_few_test_positives +12326,83419,21.946764,0.96875,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.96240234,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,16.0,18.0,323.14905149051486,5.839985987475487e-39,Beta-sheet edge recognition loop,True,assigned_too_few_test_positives +12327,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal catalytic pocket surface,False,no_term_above_threshold +12328,27735,16.429653,0.7993164,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,87857,Nucleus,0.67333984,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.893062786608282,0.059503074068239424,0.011519716437749225,,5.165324545077553,0.0,20.0,0.0,1.0,Phosphorylation-prone S/T-rich IDRs,True,assigned_and_evaluated +12329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,His/Cys-flanking amphipathic helices,False,no_term_above_threshold +12330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small mitochondrial assembly factors,False,no_term_above_threshold +12331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-targeting regulatory IDRs,False,no_term_above_threshold +12332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic MoRF hotspots in IDRs,False,no_term_above_threshold +12333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,E2 catalytic core/transducer,False,no_term_above_threshold +12334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered Q/K/E patches,False,no_term_above_threshold +12335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-pocket beta strands,False,no_term_above_threshold +12336,36091,27.104572,0.98876953,GNAT domain,interpro,85712,3.40.630.30,0.95751953,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,Kinase activation loop motif,True,assigned_too_few_test_positives +12337,87489,21.41084,0.9536133,GPI-anchor,keyword,88058,Signal,0.66503906,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.9907301587301588,0.6303915183094514,0.0031014621178555605,0.8571428571428571,203.25623668920454,15.0,20.0,110.40925925925927,1.2272172356604381e-28,C-terminal GPI anchor signal,True,assigned_and_evaluated +12338,50338,25.055656,0.94140625,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.87060547,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,GT-C TM-lumen interface,True,assigned_too_few_test_positives +12339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal boundary detector,False,no_term_above_threshold +12340,82029,30.886164,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,14.0,18.0,146.28356116368735,1.1361961835000335e-28,TM6/TM12 cytosolic exit motif,True,assigned_too_few_test_positives +12341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix C-terminus regulatory linkers,False,no_term_above_threshold +12342,64155,16.771713,0.84716797,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.8408203,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,13.0,13.0,277.30697674418604,5.166024449502295e-32,RNase H-like nuclease core,True,assigned_too_few_test_positives +12343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helix-capping junction motifs,False,no_term_above_threshold +12344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +12345,69819,20.08969,0.92333984,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8959961,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,17.0,17.0,419.86619718309856,1.776833158726609e-44,Glycine-rich phosphate-binding loops,True,assigned_too_few_test_positives +12346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic N-terminal translocation regions,False,no_term_above_threshold +12347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site capping motifs,False,no_term_above_threshold +12348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positively charged phosphate-binding surfaces,False,no_term_above_threshold +12349,59211,22.420189,0.99316406,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.99316406,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,1.0,1.0,0.011076650420912717,1.0,90.28,19.0,19.0,244.34836065573774,4.317107890414195e-45,Donor NDP-sugar pocket helix,True,assigned_and_evaluated +12350,36272,16.433022,0.95166016,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.95166016,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,13.0,0.0,1.0,Substrate/cofactor-binding hotspots,True,assigned_too_few_test_positives +12351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PKS DH hotdog motif,False,no_term_above_threshold +12352,81685,23.090063,0.96240234,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.85839844,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9569784706755753,0.8910680660168366,0.005316792202038104,0.9166666666666666,167.59505208333334,19.0,19.0,85.66235632183908,8.858414841848649e-37,APE-like activation-segment anchor,True,assigned_and_evaluated +12353,82029,31.96665,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99072266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,16.0,188.0788643533123,1.615494529537867e-36,Glycine-rich MFS core helices,True,assigned_too_few_test_positives +12354,49236,23.186562,0.9580078,C-type lectin fold,interpro,49236,C-type lectin fold,0.9580078,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.8966696269982237,0.4013954469692175,0.002215330084182543,0.8,181.18990476190478,0.0,13.0,0.0,1.0,Metzincin prodomain activation segment,True,assigned_and_evaluated +12355,85649,19.093983,0.93310547,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.93310547,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9293429605698493,0.4020512968877192,0.0101905183872397,0.4782608695652174,39.45346856850357,1.0,13.0,8.508776937348365,0.17965685453583757,Catalytic beta-strand micro-motifs,True,assigned_and_evaluated +12356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribosyltransferase/NADase fold,False,no_term_above_threshold +12357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular C-terminal accessory segments,False,no_term_above_threshold +12358,36104,20.754332,0.84814453,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.84814453,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Glycan-assembly loop-helix junction,True,assigned_too_few_test_positives +12359,15821,17.231276,0.62841797,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.62841797,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,13.0,0.0,1.0,Transporter core TM helix pairs,True,assigned_too_few_test_positives +12360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic phosphate-binding N-caps,False,no_term_above_threshold +12361,50338,16.897558,0.99853516,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.95166016,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,17.0,17.0,392.24342105263156,5.553476033233558e-44,GPCR ECL2 disulfide motif,True,assigned_too_few_test_positives +12362,43583,17.213087,0.93652344,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.93652344,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,15.0,16.0,390.87194055944053,2.606245505866116e-38,Clan PA S1 specificity loop,True,assigned_and_evaluated +12363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic α-helical interaction faces,False,no_term_above_threshold +12364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic acidic flexible segments,False,no_term_above_threshold +12365,58239,36.16735,0.8198242,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8198242,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.9428337843933243,0.6979574254377593,0.017722640673460344,0.725,39.382247730325574,14.0,16.0,31.370039085989173,4.842200373606209e-20,Switch I-like regulatory loop,True,assigned_and_evaluated +12366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted beta-strand repeat motifs,False,no_term_above_threshold +12367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fe-ADH C-terminal helix-loop,False,no_term_above_threshold +12368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosidic and HKD catalytic cores,False,no_term_above_threshold +12369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Keratinization cysteine-rich repeats,False,no_term_above_threshold +12370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-lining amphipathic helices,False,no_term_above_threshold +12371,59224,28.573832,0.98535156,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.98535156,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,18.0,18.0,137.37557603686636,1.6332112516921354e-38,AB-hydrolase helix-beta loops,True,assigned_and_evaluated +12372,64148,17.855263,0.6347656,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6347656,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5464347866986501,0.11279528018095748,0.008418254319893664,0.10526315789473684,13.398891966759003,19.0,19.0,88.9865671641791,4.383349844353145e-37,GntR-like C-terminal effector/dimerization domain,True,assigned_and_evaluated +12373,81858,18.893244,0.9707031,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.65771484,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,8.0,14.0,149.42606516290726,2.851605007346443e-16,Hydrophobic GPCR TM6 helix,True,assigned_too_few_test_positives +12374,55053,19.036594,0.92529297,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.92529297,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,10.0,11.0,501.86026936026934,8.78399456430145e-27,Cap/hinge and S/T-IDR hotspots,True,assigned_too_few_test_positives +12375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand lipid-handling architectures,False,no_term_above_threshold +12376,63951,24.013885,0.9848633,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.8803711,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9984677738236457,0.5538029871363206,0.003987594151528578,1.0,138.88148244074173,17.0,17.0,161.13783783783785,1.3433661058868306e-37,Extracellular Ig-like ectodomains,True,assigned_and_evaluated +12377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDRs and terminal MoRFs,False,no_term_above_threshold +12378,45324,19.963295,0.97753906,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.97753906,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9966252220248668,0.2675396825396825,0.002215330084182543,,120.7674126984127,15.0,15.0,546.9816513761467,3.1549135532889026e-41,PbH1 beta-helix repeats,True,assigned_and_evaluated +12379,81858,19.085627,0.8276367,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8276367,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane boundary gating elements,True,assigned_too_few_test_positives +12380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted disordered low-complexity tails,False,no_term_above_threshold +12381,81858,17.57666,0.9501953,Rhodopsin 7-helix transmembrane proteins,gene3d,88006,Receptor,0.7451172,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,14.0,14.0,261.4956140350877,4.609747592190934e-34,Class A GPCR cytoplasmic interface,True,assigned_too_few_test_positives +12382,85672,31.448061,0.76464844,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.75,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7793849117014359,0.32875328752355865,0.01595037660611431,0.25,20.61100472057422,16.0,16.0,40.01409395973155,6.696154575406941e-26,Helicase ATPase motor core,True,assigned_and_evaluated +12383,38890,23.149235,0.99853516,HNH nuclease,interpro,38890,HNH nuclease,0.99853516,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,11.0,19.0,750.3787185354691,4.513599968631909e-30,Histidine-centered nuclease catalytic patch,True,assigned_too_few_test_positives +12384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helices with catalytic residues,False,no_term_above_threshold +12385,88058,20.274721,0.60791016,Signal,keyword,88058,Signal,0.60791016,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6101759501640214,0.10608098981115985,0.09127159946832078,,1.1622562815717854,2.0,20.0,0.7204954682779456,1.0,Aromatic F/Y cluster motif,True,assigned_and_evaluated +12386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant TBL O-acetyltransferases,False,no_term_above_threshold +12387,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic low-complexity N-termini,False,no_term_above_threshold +12388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-cap detector,False,no_term_above_threshold +12389,38873,16.004278,0.68408203,AAA+ ATPase domain,interpro,38873,AAA+ ATPase domain,0.68408203,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.6976021314387212,0.40132919805050954,0.002215330084182543,0.4,181.16000000000003,8.0,8.0,171.32471264367817,3.093783670371934e-18,ABC NBD Q-loop coupling helix,True,assigned_and_evaluated +12390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial secretion coiled-coil helices,False,no_term_above_threshold +12391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymorphic toxin scaffold activation,False,no_term_above_threshold +12392,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal output helix and tail,False,no_term_above_threshold +12393,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-rich active domain cores,False,no_term_above_threshold +12394,87913,23.50638,1.0,Phosphopantetheine,keyword,87913,Phosphopantetheine,1.0,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.9640468759951595,0.929014494588265,0.006202924235711121,0.9285714285714286,149.7704081632653,14.0,14.0,480.8145161290322,8.741512687097007e-38,Carrier domain entry linker,True,assigned_and_evaluated +12395,45317,17.302494,0.95703125,"Six-bladed beta-propeller, TolB-like",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.67871094,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,8.0,18.0,339.7207977207977,6.489387124029568e-19,WD40/YWTD/Asp-box beta-propellers,True,assigned_too_few_test_positives +12396,36354,17.60186,0.94433594,RNA recognition motif domain,interpro,64058,NAD(P)-binding domain superfamily,0.90722656,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,10.0,0.0,1.0,Acidic/polar helix N-cap motif,True,assigned_too_few_test_positives +12397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended polynucleotide-binding surfaces,False,no_term_above_threshold +12398,38317,26.185955,0.99121094,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.99121094,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9739682539682539,0.06013904789913907,0.0031014621178555605,,19.39054730119384,0.0,12.0,0.0,1.0,SDR dual helical motif,True,assigned_and_evaluated +12399,36535,22.131546,0.9584961,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.95166016,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9489541611036938,0.8822612478350184,0.004430660168365086,0.9,199.12636363636366,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase APE activation segment,True,assigned_and_evaluated +12400,45324,18.908842,0.9296875,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9296875,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9963587921847247,0.25348290598290596,0.002215330084182543,,114.42218376068375,14.0,15.0,510.5162079510703,1.865407917563931e-37,Extracellular beta-helix CAZymes,True,assigned_and_evaluated +12401,36104,16.511768,0.9995117,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9995117,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Amphipathic alpha-helical oligomerization segments,True,assigned_too_few_test_positives +12402,63831,17.887323,0.8754883,F-box-like domain superfamily,interpro,43624,Homedomain-like superfamily,0.8623047,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.7105730786317193,0.005436245636236015,0.002658396101019052,,2.0449344001641143,0.0,14.0,0.0,1.0,Solvent-exposed polar alpha helices,True,assigned_and_evaluated +12403,64148,34.43672,0.8540039,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7963867,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9120102535158271,0.34029909145707843,0.008418254319893664,0.10526315789473684,40.42394996940137,14.0,15.0,83.05412935323383,2.1124960830088156e-26,Coiled-coil dimerization helices,True,assigned_and_evaluated +12404,87198,16.672033,0.81591797,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.81591797,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,10.0,17.0,427.69727403156384,7.9292749536536815e-25,Disordered N-terminal export signals,True,assigned_too_few_test_positives +12405,38317,19.796549,0.77246094,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.77246094,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6327619047619046,0.016872101883811483,0.0031014621178555605,,5.440047707394645,0.0,17.0,0.0,1.0,ABC NBD2 mid-domain activation,True,assigned_and_evaluated +12406,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-loop-alpha phosphate-binding module,False,no_term_above_threshold +12407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-binding β-sandwich domains,False,no_term_above_threshold +12408,64596,15.710154,0.9082031,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,59224,Alpha/Beta hydrolase fold,0.7792969,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,0.0,16.0,0.0,1.0,Catalytic Ser/Cys nucleophile elbow,True,assigned_too_few_test_positives +12409,59224,15.646434,0.89941406,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8027344,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9471111111111112,0.04321325922263688,0.0031014621178555605,,13.933189437927348,0.0,17.0,0.0,1.0,Charged surface alpha-helices,True,assigned_and_evaluated +12410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved mid-domain surface hotspot,False,no_term_above_threshold +12411,55053,18.271784,0.9394531,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9394531,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,19.0,0.0,1.0,Tyrosine recombinase/topoisomerase catalytic domain,True,assigned_too_few_test_positives +12412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble hydrophobic ligand binding domains,False,no_term_above_threshold +12413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand start motifs,False,no_term_above_threshold +12414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal DNA entry module,False,no_term_above_threshold +12415,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended non-transmembrane interaction domains,False,no_term_above_threshold +12416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adaptor domains and linkers,False,no_term_above_threshold +12417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic C-terminal domains and tails,False,no_term_above_threshold +12418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-tunable interaction hubs,False,no_term_above_threshold +12419,49061,30.725653,0.96435547,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96435547,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.6944738191373454,0.1298590345019919,0.012405848471422242,,10.467565745392704,10.0,20.0,49.43698175787728,4.108984195041572e-15,Beta-propeller blade strands,True,assigned_and_evaluated +12420,25167,18.525023,0.6640625,cell outer membrane,go_cc,25167,cell outer membrane,0.6640625,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7893281365998517,0.48045607082492325,0.005316792202038104,0.5833333333333334,90.36577932098764,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel signature,True,assigned_and_evaluated +12421,58239,23.362732,0.6850586,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6850586,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6721583220568336,0.1601651800737648,0.017722640673460344,0.05,9.03732028566218,11.0,17.0,23.19801209720208,1.8388180308421842e-13,Broad non-core activation,True,assigned_and_evaluated +12422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protein mature-chain activation,False,no_term_above_threshold +12423,45290,16.26232,0.6850586,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.6850586,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6090429178664474,0.23519989093759586,0.0057598582188746125,0.23076923076923078,40.83431952662722,2.0,11.0,13.3499776085983,0.016017785146138896,Nucleotide-handling catalytic cores,True,assigned_and_evaluated +12424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant transcriptional regulatory IDRs,False,no_term_above_threshold +12425,29034,18.122793,0.66064453,GTP binding,go_mf,29034,GTP binding,0.66064453,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.6668305766651766,0.1828966103556267,0.008861320336730172,0.15,20.639882478632476,12.0,12.0,129.6108695652174,1.192992154739222e-25,NTPase C-terminal effector domains,True,assigned_and_evaluated +12426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-spanning scaffolding segments,False,no_term_above_threshold +12427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel loops,False,no_term_above_threshold +12428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic oligomerization helices,False,no_term_above_threshold +12429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"uL15 Gly-rich tails, FGGY TYGTG",False,no_term_above_threshold +12430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured binding/catalytic core domains,False,no_term_above_threshold +12431,39971,17.842407,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98583984,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,17.0,17.0,662.4555555555555,9.487459772151499e-48,Binuclear metallo-phosphoesterase active site,True,assigned_too_few_test_positives +12432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core helical scaffold detector,False,no_term_above_threshold +12433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase palm subdomain motif,False,no_term_above_threshold +12434,49121,16.787172,0.9692383,"Signal transduction response regulator, C-terminal effector",interpro,43624,Homedomain-like superfamily,0.77734375,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,19.0,20.0,928.5237704918034,6.484249024027352e-55,HTH/homeobox pre-DBD linker,True,assigned_too_few_test_positives +12435,63892,19.315845,0.9423828,Fibronectin type III superfamily,interpro,47529,Immunoglobulin-like fold,0.7128906,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,16.0,18.0,257.2642934196332,2.1827294665727175e-37,FN3/Ig-like beta-sandwiches,True,assigned_too_few_test_positives +12436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved motif residue peaks,False,no_term_above_threshold +12437,49236,22.149788,0.88427734,C-type lectin fold,interpro,49236,C-type lectin fold,0.88427734,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.7936056838365897,0.07968730162431628,0.002215330084182543,,35.97084795321637,4.0,12.0,180.66969696969696,1.0868860362617809e-08,Jelly-roll β-sandwich cores,True,assigned_and_evaluated +12438,59229,16.662203,0.6308594,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6308594,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.6337433342415633,0.02690341938889762,0.0101905183872397,,2.640044241771388,16.0,17.0,100.02474572716787,2.1086661383518e-31,Rossmann-like RNA MTase domain,True,assigned_and_evaluated +12439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-binding surface loops,False,no_term_above_threshold +12440,50338,20.939058,0.86035156,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.82128906,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Juxtamembrane helix boundary hotspots,True,assigned_too_few_test_positives +12441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity interaction tracts,False,no_term_above_threshold +12442,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ntn alpha-chain scaffold recognition,False,no_term_above_threshold +12443,36091,17.90492,0.9995117,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9892578,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,17.0,17.0,377.3481012658228,1.0362764569171756e-43,GNAT catalytic Tyr motif,True,assigned_too_few_test_positives +12444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NB-ARC/NACHT P-loop NTPase,False,no_term_above_threshold +12445,87326,19.84322,0.64941406,Coiled coil,keyword,87326,Coiled coil,0.64941406,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6408614577718811,0.06988622759714196,0.03943287549844927,,1.772283322323027,2.0,14.0,1.8010754312297979,0.4791914308832892,Amphipathic helical bundles,True,assigned_and_evaluated +12446,43643,17.48368,1.0,Phosphopantetheine binding ACP domain,interpro,87913,Phosphopantetheine,1.0,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,1.0,1.0,0.0057598582188746125,1.0,173.6153846153846,15.0,15.0,527.6194690265487,5.435829659838727e-41,Glycine-rich Ppant/ATP loops,True,assigned_and_evaluated +12447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad intradomain activation segment,False,no_term_above_threshold +12448,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic micro-motifs,False,no_term_above_threshold +12449,45324,22.604712,0.98095703,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.98095703,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.4900088809946714,0.002215330084182543,0.002215330084182543,,1.0,15.0,16.0,512.7952981651376,4.266976294111953e-40,Extracellular β-helix/β-solenoid passengers,True,assigned_and_evaluated +12450,50338,17.309616,0.9760742,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9589844,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,16.0,16.0,392.24342105263156,1.485323444055259e-41,GPCR helix 8 proximal C-tail,True,assigned_too_few_test_positives +12451,39971,20.910048,0.7988281,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.7871094,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,11.0,18.0,404.833950617284,5.062832088999384e-27,Nucleotidase/apyrase YPxxV motif,True,assigned_too_few_test_positives +12452,64507,40.312607,0.9951172,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9951172,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9987643337287465,0.8339970296110648,0.003987594151528578,0.7777777777777778,209.14792175913038,17.0,17.0,165.15512465373962,8.860288009731091e-38,Ankyrin helix periodic hotspot,True,assigned_and_evaluated +12453,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LXG N-terminal secretion domain,False,no_term_above_threshold +12454,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding catalytic alpha/beta cores,False,no_term_above_threshold +12455,37690,15.906835,0.9145508,Ankyrin repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8647461,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9649841269841269,0.07532782296236565,0.0031014621178555605,,24.287842346579897,1.0,17.0,10.627629233511586,0.14615989449547315,Cytosolic α-helix cap/turn marker,True,assigned_and_evaluated +12456,85656,22.746737,0.85009766,alpha/beta hydrolase,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.7734375,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.8232698412698413,0.03956837872132009,0.0031014621178555605,,12.757975824859919,0.0,13.0,0.0,1.0,Buried α/β β‑strand cores,True,assigned_and_evaluated +12457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intracellular coupling helices,False,no_term_above_threshold +12458,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue low-complexity segments,False,no_term_above_threshold +12459,25169,18.397758,0.78222656,pilus,go_cc,25169,pilus,0.78222656,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7950266429840143,0.2575527987003397,0.002215330084182543,0.2,116.25933333333334,3.0,18.0,92.00771604938271,8.716043774821798e-06,Targeting motifs and hinge/nucleophile hotspots,True,assigned_and_evaluated +12460,83267,20.624817,0.9970703,DNA-binding pseudobarrel domain,gene3d,48767,DNA-binding pseudobarrel domain superfamily,0.99658203,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,18.0,0.0,1.0,Beta-strand hydrophobic core detector,True,assigned_too_few_test_positives +12461,36104,17.17901,0.8198242,Rho GTPase-activating protein domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6557617,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,ASCE P-loop ATPase motors,True,assigned_too_few_test_positives +12462,45290,15.818033,0.8701172,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.8701172,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.895533388180447,0.05266458343341261,0.0057598582188746125,,9.143381908400944,1.0,17.0,4.319110402781803,0.3278983179026701,Mixed-charge loop micro-motifs,True,assigned_and_evaluated +12463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/PAC sensory domains,False,no_term_above_threshold +12464,81685,15.729942,0.67871094,Transferase(Phosphotransferase) domain 1,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.67871094,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.6617297698589458,0.059123426360649114,0.005316792202038104,,11.120131107998754,0.0,13.0,0.0,1.0,Glycoside hydrolase catalytic cleft,True,assigned_and_evaluated +12465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic TonB-box hinge motif,False,no_term_above_threshold +12466,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IWxFGP A-site contact motif,False,no_term_above_threshold +12467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Subunit assembly interface belts,False,no_term_above_threshold +12468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HSP90 M-domain motif hotspot,False,no_term_above_threshold +12469,35372,18.667168,0.9501953,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9501953,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,4.0,17.0,165.04083044982698,1.8134947656264574e-08,Conserved TM helix packing motifs,True,assigned_too_few_test_positives +12470,29166,15.99083,0.6879883,zinc ion binding,go_mf,29166,zinc ion binding,0.6879883,702,go,GO:0008270,go_mf:go:GO:0008270,49.0,2257.0,0.8704479074238392,0.1381610982611751,0.021710234824988923,,6.3638693627647385,6.0,17.0,6.321029102539184,0.0003938648237102703,Aminergic GPCR TM5-TM6 motif,True,assigned_and_evaluated +12471,48883,18.685568,0.9819336,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9819336,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,PLP phosphate binding loop,True,assigned_too_few_test_positives +12472,49116,21.898184,0.8847656,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8847656,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9960035523978685,0.319830743968675,0.002215330084182543,0.2,144.3715978274599,13.0,20.0,56.574671532846715,1.0349183084028314e-20,Alpha-solenoid HEAT/ARM scaffolds,True,assigned_and_evaluated +12473,84991,15.833723,0.9995117,3.30.70.20,gene3d,87697,Knottin,0.89453125,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,19.0,20.0,658.6040697674418,6.986558341404003e-52,Fe–S cluster-binding cysteine motifs,True,assigned_too_few_test_positives +12474,48880,18.18107,0.9995117,"Pyridoxal phosphate-dependent transferase, major domain",interpro,69093,"ANL, N-terminal domain",0.953125,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,Active-site substrate-gating loop,True,assigned_too_few_test_positives +12475,82029,23.867819,0.9995117,MFS general substrate transporter like domains,gene3d,25079,plasma membrane,0.61328125,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,16.0,188.0788643533123,1.615494529537867e-36,MFS/SLC transmembrane helix scaffold,True,assigned_too_few_test_positives +12476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme alpha/beta core hydrophobics,False,no_term_above_threshold +12477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter cytoplasmic linker,False,no_term_above_threshold +12478,87913,15.864169,0.8041992,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.8041992,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8529074581236865,0.22502412983635023,0.006202924235711121,,36.27710436004589,0.0,18.0,0.0,1.0,Membrane-proximal beta-edge loops,True,assigned_and_evaluated +12479,37468,25.474281,0.99365234,"Zinc finger, RING-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.9819336,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,17.0,18.0,129.74359959037378,3.115927601669942e-35,RING E3 flanking activation,True,assigned_too_few_test_positives +12480,85364,23.112488,0.9785156,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9785156,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,N-terminal starter β-strands,True,assigned_too_few_test_positives +12481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact structured-domain patch,False,no_term_above_threshold +12482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible N-terminal capping loops,False,no_term_above_threshold +12483,36449,15.747511,1.0,EamA domain,interpro,87276,Cell membrane,0.6191406,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,12.0,17.0,751.5252100840337,3.7418058845448926e-33,Extracytoplasmic helix-entry anchors,True,assigned_too_few_test_positives +12484,87326,33.108295,0.66308594,Coiled coil,keyword,87326,Coiled coil,0.66308594,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6340307433973217,0.2291704995445835,0.03943287549844927,0.21348314606741572,5.811660870473314,14.0,16.0,11.031587016282513,8.974902762585022e-14,Coiled-coil dimerization stalks,True,assigned_and_evaluated +12485,36104,16.980455,0.99609375,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.98876953,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,20.0,0.0,1.0,Surface-exposed interaction segments,True,assigned_too_few_test_positives +12486,87697,20.117352,0.8725586,Knottin,keyword,87413,Disulfide bond,0.6977539,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9140771311645973,0.08603808802129781,0.017279574656623838,,4.979178581129978,0.0,17.0,0.0,1.0,Extracellular disulfide-bonded repeats,True,assigned_and_evaluated +12487,87317,21.158993,0.8457031,Cleavage on pair of basic residues,keyword,88058,Signal,0.64501953,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9581938866577421,0.5909046348000316,0.007089056269384138,0.5625,83.35448504647947,16.0,16.0,84.44900849858357,5.042374073638017e-31,Signal-proximal disordered propeptides,True,assigned_and_evaluated +12488,82597,40.324577,0.99121094,Tetratricopeptide repeat domain,gene3d,46079,Tetratricopeptide-like helical domain superfamily,0.99072266,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9988173591114768,0.8257239982239981,0.0057598582188746125,1.0,143.3583895378126,17.0,18.0,92.00771604938271,9.895180931147039e-33,TPR-like α-solenoid repeats,True,assigned_and_evaluated +12489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory disordered protein tails,False,no_term_above_threshold +12490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich transmembrane helices,False,no_term_above_threshold +12491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymeric structural assembly cores,False,no_term_above_threshold +12492,63951,19.14099,0.9707031,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9692383,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9952303281929616,0.3541369522552318,0.003987594151528578,0.1111111111111111,88.80967791556202,7.0,20.0,56.39824324324324,5.1744340826680994e-11,Solvent-exposed ectodomain loops,True,assigned_and_evaluated +12493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-binding extracellular domains,False,no_term_above_threshold +12494,85682,18.324293,0.6142578,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6142578,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.5370878136200717,0.029677697874419186,0.011076650420912717,,2.679302564102564,9.0,15.0,61.359519725557455,8.502129427582305e-15,Acidic glycine-rich anion-binding cores,True,assigned_and_evaluated +12495,85649,31.710676,0.7548828,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7529297,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6060682729360476,0.22536649265088324,0.0101905183872397,0.21739130434782608,22.115311909262758,15.0,18.0,92.17841682127396,4.9085152159456985e-28,Rossmann-like SAM MTase core,True,assigned_and_evaluated +12496,85762,27.81184,0.7705078,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.7705078,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,14.0,15.0,191.88367816091954,1.8657785697872937e-31,Flavin amine oxidase substrate lobe,True,assigned_too_few_test_positives +12497,37640,16.577322,0.6923828,EF-hand domain,interpro,37640,EF-hand domain,0.6923828,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,18.0,0.0,1.0,WD/YWTD/FG-GAP propellers,True,assigned_too_few_test_positives +12498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature prepilin-type filament body,False,no_term_above_threshold +12499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic polyprenol-binding transmembrane helices,False,no_term_above_threshold +12500,85364,25.480833,0.97509766,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.97509766,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,N-terminal lipoprotein leader/linker,True,assigned_too_few_test_positives +12501,46079,26.279732,0.96191406,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.96191406,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9814548196901138,0.14832088119436204,0.0057598582188746125,,25.750786835051933,0.0,19.0,0.0,1.0,Charged helix-capping loop,True,assigned_and_evaluated +12502,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cationic tails and helix-turns,False,no_term_above_threshold +12503,45288,19.5161,0.9995117,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9995117,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,17.0,17.0,462.17829457364337,3.827449248759242e-45,REC domain C-terminal linker,True,assigned_too_few_test_positives +12504,72011,22.620665,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.92089844,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,12.0,12.0,590.3069306930694,1.332339058103845e-33,ANL adenylation active-site loops,True,assigned_too_few_test_positives +12505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal prosegment marker,False,no_term_above_threshold +12506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal glycosyltransferase acceptor loops,False,no_term_above_threshold +12507,85672,19.032423,0.7675781,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.76171875,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8067687227975385,0.049312568275594854,0.01595037660611431,,3.0916240721671553,0.0,18.0,0.0,1.0,Acidic glycine-rich interface loops,True,assigned_and_evaluated +12508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface amphipathic loops,False,no_term_above_threshold +12509,85364,16.967133,0.7871094,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7871094,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,11.0,19.0,174.33040935672517,8.48342799084619e-23,C-terminal helix-capping segment,True,assigned_too_few_test_positives +12510,85672,16.147675,0.72509766,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.71484375,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7970008504677575,0.04031540188489446,0.01595037660611431,,2.5275517237279663,0.0,16.0,0.0,1.0,Active-site boundary microenvironments,True,assigned_and_evaluated +12511,45553,16.207321,0.8491211,Restriction endonuclease type II-like,interpro,45553,Restriction endonuclease type II-like,0.8491211,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,2.0,18.0,76.14431673052363,0.0005676923219839566,Basic nucleic acid binding helix,True,assigned_too_few_test_positives +12512,45804,25.424046,0.92285156,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.8745117,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,17.0,17.0,276.02314814814815,1.7512156980327852e-41,MFS TM7–TM8 gate detector,True,assigned_too_few_test_positives +12513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TMTC TM-to-TPR junction motif,False,no_term_above_threshold +12514,64507,32.938313,0.9980469,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9980469,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997528667457493,0.9436868686868687,0.003987594151528578,1.0,236.65569584736252,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat H1 hydrophobic core,True,assigned_and_evaluated +12515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted alpha-helical subdomain,False,no_term_above_threshold +12516,82107,17.976774,0.7885742,1.20.1280.50,gene3d,37446,F-box domain,0.77441406,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,17.0,0.0,1.0,Proline–aspartate helix–strand pivot,True,assigned_too_few_test_positives +12517,36914,17.001846,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9897461,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,18.0,695.1694101508916,2.0253100882060637e-47,Glycosyltransferase loop–β donor-site motif,True,assigned_too_few_test_positives +12518,50338,17.28329,0.7368164,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.7368164,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,12.0,0.0,1.0,6-TM cation channel pore detector,True,assigned_too_few_test_positives +12519,88164,18.332731,0.85498047,Transposition,keyword,88164,Transposition,0.85498047,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.5872113676731794,0.0684389307340127,0.002215330084182543,,30.893333333333338,5.0,15.0,242.36178861788616,2.7730017925442578e-11,DDE recombinase core helix,True,assigned_and_evaluated +12520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface β-edge interaction motif,False,no_term_above_threshold +12521,47128,17.154562,0.90527344,Concanavalin A-like lectin/glucanase domain superfamily,interpro,25169,pilus,0.87841797,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,9.0,20.0,115.64418103448276,6.863656579876728e-17,Ectodomain beta-edge repeats,True,assigned_too_few_test_positives +12522,45290,21.866741,0.77441406,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.77441406,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6465446318387494,0.045978936142870575,0.0057598582188746125,,7.982650682650683,0.0,17.0,0.0,1.0,Metal phosphate-binding beta hairpin,True,assigned_and_evaluated +12523,49061,26.943665,0.98291016,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98291016,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9958181119015573,0.5721487857199729,0.012405848471422242,1.0,46.11927890607067,9.0,19.0,46.835035349567946,1.9804885127840417e-13,Hydrophobic beta-propeller blade core,True,assigned_and_evaluated +12524,25169,19.886786,0.8544922,pilus,go_cc,25169,pilus,0.8544922,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8955595026642984,0.34472878030255083,0.002215330084182543,0.8,155.61057142857146,2.0,18.0,61.33847736625514,0.0008672906665695163,Focal adhesin beta-strand activation,True,assigned_and_evaluated +12525,37430,17.179676,0.98291016,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,0.98291016,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,19.0,19.0,484.7235772357723,2.572132453150849e-50,REC D+5 site,True,assigned_too_few_test_positives +12526,72011,19.718168,0.99121094,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9819336,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,2.0,17.0,69.44787419918462,0.0006784606596860959,Active-site ATP/substrate-binding motif,True,assigned_too_few_test_positives +12527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix–loop junctions,False,no_term_above_threshold +12528,47128,23.138042,0.94384766,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.94384766,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,11.0,13.0,217.45059681697612,5.701679593821027e-25,Beta-sandwich glycan-binding faces,True,assigned_too_few_test_positives +12529,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed hydrophobic helical patches,False,no_term_above_threshold +12530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity membrane loops,False,no_term_above_threshold +12531,63960,15.962764,0.71728516,FAD/NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6723633,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,NAD(P) Rossmann β–loop–α motif,True,assigned_too_few_test_positives +12532,69819,16.69296,0.68115234,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.6713867,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,0.0,16.0,0.0,1.0,Phosphate-binding helix-loop motif,True,assigned_too_few_test_positives +12533,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif III coupling loop,False,no_term_above_threshold +12534,37312,17.709742,1.0,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",1.0,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,18.0,19.0,818.5949656750571,4.3313349653425253e-51,TetR post-HTH hinge helix,True,assigned_too_few_test_positives +12535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical hairpin block,False,no_term_above_threshold +12536,87413,26.764744,0.60302734,Disulfide bond,keyword,87413,Disulfide bond,0.60302734,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.570980288164059,0.16055814792306156,0.0717766947275144,0.13580246913580246,2.23691197445895,8.0,15.0,6.307848971764861,1.8122001659189266e-05,Mature secreted domain activation,True,assigned_and_evaluated +12537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich cofactor-binding loop,False,no_term_above_threshold +12538,37020,17.910143,0.98291016,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9682617,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,4.0,17.0,192.17082997582594,9.858057841790817e-09,Glycosyltransferase donor-binding region,True,assigned_too_few_test_positives +12539,50869,16.80603,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.75927734,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,20.0,20.0,917.2461538461538,5.886799965512069e-58,HTH/homeodomain amphipathic helix,True,assigned_too_few_test_positives +12540,3751,16.10479,0.9135742,DNA-directed DNA polymerase,ec,46274,Ribonuclease H-like superfamily,0.7626953,26,ec,2.7.7.7,ec:ec:2.7.7.7,,,,,,,,9.0,13.0,396.88535502958575,2.0623311340529742e-22,DEDD(h/y) 3'-5' exonuclease core,True,assigned_too_few_test_positives +12541,36091,19.352396,0.9824219,GNAT domain,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9716797,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,Post-motif I SAM-pocket helix,True,assigned_too_few_test_positives +12542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA repair linker/nuclease regions,False,no_term_above_threshold +12543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical oligomerization segments,False,no_term_above_threshold +12544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann N-terminal beta-alpha element,False,no_term_above_threshold +12545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic phosphorylation-dense IDR linkers,False,no_term_above_threshold +12546,50806,18.35996,0.99609375,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9667969,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,HTH DNA-binding turn,True,assigned_too_few_test_positives +12547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic domains of multipass proteins,False,no_term_above_threshold +12548,85364,23.396372,0.99609375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.99609375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Pocket-flanking helices/loops,True,assigned_too_few_test_positives +12549,81799,23.046398,0.9604492,1.10.8.60,gene3d,81799,1.10.8.60,0.9604492,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,8.0,10.0,463.0757281553398,7.181259955666263e-21,AAA+ C-terminal docking region,True,assigned_too_few_test_positives +12550,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal basic amphipathic engagement,False,no_term_above_threshold +12551,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAH-fold Gx[SC]K motif detector,False,no_term_above_threshold +12552,43583,18.38781,0.9848633,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9848633,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,18.0,18.0,416.9300699300699,7.421898268411123e-47,Trypsin-like zymogen activation segments,True,assigned_and_evaluated +12553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ZU5-UPA module detector,False,no_term_above_threshold +12554,88147,15.572535,0.7705078,Toxin-antitoxin system,keyword,88147,Toxin-antitoxin system,0.7705078,120,keywords,Toxin-antitoxin system,keyword:keywords:Toxin-antitoxin system,10.0,2257.0,0.837716955941255,0.6578768170981285,0.004430660168365086,0.7,148.4827976190476,17.0,18.0,223.44731040564372,3.4889395789442207e-39,Short charge-rich interface SLiMs,True,assigned_and_evaluated +12555,46078,20.574245,0.98876953,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9824219,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,19.0,19.0,130.74780701754386,3.676010515894859e-40,Alpha-solenoid repeat register,True,assigned_too_few_test_positives +12556,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-biased amphipathic alpha-helix,False,no_term_above_threshold +12557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TRUD-domain pseudouridine synthases,False,no_term_above_threshold +12558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted glycosylated ectodomains with autoproteolysis,False,no_term_above_threshold +12559,49116,26.094082,0.98876953,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.98876953,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,19.0,19.0,87.03795620437957,6.605101239071875e-37,HEAT-repeat hydrophobic helix cores,True,assigned_and_evaluated +12560,38654,21.193674,0.9375,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.92871094,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,14.0,0.0,1.0,Cupredoxin N-terminal strand-loop,True,assigned_too_few_test_positives +12561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helices and IMS tails,False,no_term_above_threshold +12562,36535,17.617228,0.96435547,Protein kinase domain,interpro,64507,Ankyrin repeat-containing domain superfamily,0.8803711,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9416332888295504,0.8793319549057254,0.004430660168365086,0.9,198.46522222222222,17.0,17.0,89.79066265060241,2.357720211227094e-33,HRD-adjacent kinase helix peaks,True,assigned_and_evaluated +12563,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminus-biased HIT-like detector,False,no_term_above_threshold +12564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inter-domain acidic disordered linkers,False,no_term_above_threshold +12565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic interaction domains,False,no_term_above_threshold +12566,37341,20.715424,0.9921875,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99121094,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9967779438631457,0.7190921695008656,0.011962782454585734,1.0,60.110778761609396,6.0,19.0,45.92118100128369,5.234161671571501e-09,Glycine-centered repeat loop turns,True,assigned_and_evaluated +12567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic leader helix,False,no_term_above_threshold +12568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Ser-rich disordered regulatory linkers,False,no_term_above_threshold +12569,50338,16.19726,0.98095703,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.67285156,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic transmembrane helices,True,assigned_too_few_test_positives +12570,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse chain-wide activation,False,no_term_above_threshold +12571,38873,18.423698,0.98876953,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9511719,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9992895204262876,0.8433333333333333,0.002215330084182543,0.8,380.68066666666664,17.0,19.0,153.29053236539625,6.675551642670075e-36,β1 P-loop hydrophobic anchor,True,assigned_and_evaluated +12572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic leader helices,False,no_term_above_threshold +12573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal CNH scaffold domain,False,no_term_above_threshold +12574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-hairpin motif,False,no_term_above_threshold +12575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping residues,False,no_term_above_threshold +12576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S46 dipeptidase C-terminal helices,False,no_term_above_threshold +12577,45272,31.203049,0.97314453,"Lambda repressor-like, DNA-binding domain superfamily",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.97314453,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,14.0,17.0,366.4152765583845,1.3929845037599367e-34,Basic HTH initiator helix,True,assigned_too_few_test_positives +12578,47717,16.90764,0.9604492,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6328125,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,16.0,0.0,1.0,HELICc V–VI coupling region,True,assigned_too_few_test_positives +12579,87326,32.490993,0.66064453,Coiled coil,keyword,87326,Coiled coil,0.66064453,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6464949832082589,0.2506009166944578,0.03943287549844927,0.2808988764044944,6.355126617745968,19.0,19.0,12.607528018608585,3.1804487015974775e-21,Long coiled-coil scaffolding stalks,True,assigned_and_evaluated +12580,48241,25.222363,0.9848633,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9848633,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,18.0,18.0,387.14935064935065,2.6960306916448084e-46,Acidic glycine-rich binding loops,True,assigned_too_few_test_positives +12581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic low-complexity repeats,False,no_term_above_threshold +12582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine-corner β-hairpin motif,False,no_term_above_threshold +12583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gram-negative export coiled-coils,False,no_term_above_threshold +12584,87276,28.328995,0.6020508,Cell membrane,keyword,87276,Cell membrane,0.6020508,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6839809257486504,0.4285596789750381,0.11120957022596367,0.40239043824701193,3.8536222926161794,9.0,16.0,4.615581131296449,5.556094384754105e-05,Cytosolic TM helix starts,True,assigned_and_evaluated +12585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical PPI signature,False,no_term_above_threshold +12586,45290,20.154625,0.8515625,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.8515625,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7818970245440834,0.05510468729882925,0.0057598582188746125,,9.56702147949674,0.0,18.0,0.0,1.0,Metal-coordinating ATP-binding beta-strand,True,assigned_and_evaluated +12587,36886,24.409605,0.98583984,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.7558594,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9946087149844376,0.3052014405845051,0.003544528134692069,,86.1049564249035,16.0,20.0,187.0462745098039,1.8263155298582936e-34,Fungal TF disordered activation regions,True,assigned_and_evaluated +12588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site β–α loop–helix rim,False,no_term_above_threshold +12589,36104,17.18004,0.9248047,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9248047,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Surface amphipathic helix modules,True,assigned_too_few_test_positives +12590,72011,17.824219,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.94677734,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,12.0,12.0,590.3069306930694,1.332339058103845e-33,Adenylation C-lobe acceptor linker,True,assigned_too_few_test_positives +12591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motor protein C-terminal extensions,False,no_term_above_threshold +12592,-1,,,,,-1,,,0,,,,,,,,,,,,,,,T3SS N-terminal export signal,False,no_term_above_threshold +12593,50763,17.379576,0.8701172,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.796875,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,18.0,0.0,1.0,Phospho-rich disordered terminal tails,True,assigned_too_few_test_positives +12594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-pocket capping loops,False,no_term_above_threshold +12595,37312,15.594526,0.9873047,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",0.9873047,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,10.0,0.0,1.0,Charged helix-loop capping linker,True,assigned_too_few_test_positives +12596,87601,16.507452,0.60302734,Hydrolase,keyword,87601,Hydrolase,0.60302734,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.7169396350023398,0.13490030879921067,0.05316792202038104,,2.537249974665154,12.0,15.0,8.947064340649034,1.9093572446981282e-10,Catalytic beta-edge micro-motif,True,assigned_and_evaluated +12597,61392,22.126781,0.9975586,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.9975586,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9991746031746032,0.704421768707483,0.0031014621178555605,1.0,227.12570456754128,16.0,20.0,133.97977528089888,3.782270337128945e-32,LRR convex-side helices/loops,True,assigned_and_evaluated +12598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Penicillin-binding transpeptidase domain,False,no_term_above_threshold +12599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphodiester processing domain flanks,False,no_term_above_threshold +12600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PE-domain disordered-linker detector,False,no_term_above_threshold +12601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-cap motif,False,no_term_above_threshold +12602,52941,19.059845,0.9477539,Major facilitator superfamily domain,interpro,25079,plasma membrane,0.60058594,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,18.0,18.0,260.353711790393,2.623430428618387e-43,Flexible inter-TM linker loops,True,assigned_too_few_test_positives +12603,85669,15.73365,0.68408203,3.40.50.2300,gene3d,85669,3.40.50.2300,0.68408203,62,gene3d,3.40.50.2300,gene3d:gene3d:3.40.50.2300,5.0,2257.0,0.6978685612788632,0.40132919805050954,0.002215330084182543,0.4,181.16000000000003,14.0,14.0,254.79059829059833,6.647788023886972e-34,Extracytosolic ligand-binding ectodomains,True,assigned_and_evaluated +12604,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid/protein docking patches,False,no_term_above_threshold +12605,28622,18.936256,0.92285156,transposase activity,go_mf,88163,Transposable element,0.72265625,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.9933392539964475,0.1921282051282051,0.002215330084182543,,86.72667179487179,4.0,14.0,327.58791208791206,1.0598009066778387e-09,Mobile-element DBD C-terminal linkers,True,assigned_and_evaluated +12606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal structured core activation,False,no_term_above_threshold +12607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flanking disordered regulatory regions,False,no_term_above_threshold +12608,87276,28.970095,0.6088867,Cell membrane,keyword,25079,plasma membrane,0.6064453,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7147412344639389,0.45314891777487254,0.11120957022596367,0.4581673306772908,4.074729511625049,12.0,13.0,7.57428698469161,2.5740335039473363e-10,TM helix N-terminal caps,True,assigned_and_evaluated +12609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclin-like helical PPI surfaces,False,no_term_above_threshold +12610,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Opp/Dpp NBD C-tail motif,False,no_term_above_threshold +12611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory helical fold signal,False,no_term_above_threshold +12612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mycobacterial Type VII low-complexity tracts,False,no_term_above_threshold +12613,49230,16.090202,0.89697266,Acyl-CoA N-acyltransferase,interpro,64058,NAD(P)-binding domain superfamily,0.8574219,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,14.0,0.0,1.0,Soluble alpha-helix residues,True,assigned_too_few_test_positives +12614,55054,28.67127,0.9213867,HAD superfamily,interpro,55054,HAD superfamily,0.9213867,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.9993783303730017,0.7544444444444445,0.002215330084182543,1.0,340.55622222222223,10.0,10.0,334.9494382022472,1.3456627591790083e-25,P-type ATPase cytosolic beta-loops,True,assigned_and_evaluated +12615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge interaction hotspots,False,no_term_above_threshold +12616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fimbrial adhesin beta-sandwich core,False,no_term_above_threshold +12617,27936,16.819418,0.7998047,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.7998047,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,11.0,12.0,587.6621863799284,3.309190682405428e-30,PPIase-associated chaperone surfaces,True,assigned_too_few_test_positives +12618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic alpha-helical interaction modules,False,no_term_above_threshold +12619,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helical bundles,False,no_term_above_threshold +12620,88058,20.087881,0.62402344,Signal,keyword,88058,Signal,0.62402344,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6102729902060563,0.10849771930130883,0.09127159946832078,,1.188734720694437,6.0,19.0,2.275248847193512,0.06387835227892309,Disordered low-complexity regions,True,assigned_and_evaluated +12621,85682,24.64384,0.85546875,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.85546875,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9693906810035843,0.5135218934850199,0.011076650420912717,0.8,46.36075654382759,4.0,13.0,31.46642037208075,1.1321664776935652e-05,Rossmann-adjacent cofactor-binding loop,True,assigned_and_evaluated +12622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD oxidoreductase C-terminal cap,False,no_term_above_threshold +12623,59237,17.368187,0.94384766,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.94384766,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,9.0,12.0,235.34605263157897,1.6120975797084907e-20,Pro/Ser/Thr-rich disordered N-termini,True,assigned_too_few_test_positives +12624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline/acidic disordered linkers/tails,False,no_term_above_threshold +12625,87277,18.751617,0.7871094,Cell outer membrane,keyword,88058,Signal,0.74072266,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.8965396825396825,0.09257846800445524,0.0031014621178555605,,29.84994318372221,6.0,19.0,46.25966636492952,5.0112336615228205e-09,Cleaved Sec signal peptide,True,assigned_and_evaluated +12626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-cleavage N-terminal segment,False,no_term_above_threshold +12627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic membrane anchor,False,no_term_above_threshold +12628,85682,18.046993,0.7734375,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.7734375,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9057437275985661,0.11719624185578424,0.011076650420912717,,10.5804767147402,0.0,15.0,0.0,1.0,Pocket-adjacent amphipathic alpha-helices,True,assigned_and_evaluated +12629,36104,19.351906,0.85498047,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.85498047,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Function-critical transmembrane helices,True,assigned_too_few_test_positives +12630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic regulatory domains,False,no_term_above_threshold +12631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered tail detector,False,no_term_above_threshold +12632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +12633,64058,17.279972,0.6352539,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.63378906,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7792497293166041,0.45456315800578084,0.006202924235711121,0.42857142857142855,73.28207482993196,17.0,17.0,113.99808795411089,4.31985177778818e-35,Rossmann oxidoreductase catalytic loop,True,assigned_and_evaluated +12634,85388,17.490767,0.9267578,Glutaredoxin,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8730469,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.8764450867052024,0.028134150114412646,0.003544528134692069,,7.937347101028668,0.0,15.0,0.0,1.0,Beta strand cofactor pocket micromotifs,True,assigned_and_evaluated +12635,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EVH1/Ku-like binding domains,False,no_term_above_threshold +12636,84879,16.205133,0.8779297,"Histidine kinase-like ATPase, C-terminal domain",gene3d,30398,ATP hydrolysis activity,0.6435547,30,gene3d,3.30.565.10,gene3d:gene3d:3.30.565.10,,,,,,,,17.0,17.0,327.5879120879121,1.027565445798913e-42,C-terminal CA helix motif,True,assigned_too_few_test_positives +12637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transmission coiled-coils,False,no_term_above_threshold +12638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosidase TIM-barrel groove helices,False,no_term_above_threshold +12639,45804,16.781305,0.79003906,Major facilitator superfamily,interpro,45804,Major facilitator superfamily,0.79003906,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,15.0,0.0,1.0,Channel-lining transmembrane helices,True,assigned_too_few_test_positives +12640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Redox cofactor-binding catalytic cores,False,no_term_above_threshold +12641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular helical polar faces,False,no_term_above_threshold +12642,37468,19.443964,0.97802734,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.91796875,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,1.0,20.0,6.868778801843318,0.21703747417951927,Cys/His-rich metal-binding microdomains,True,assigned_too_few_test_positives +12643,64058,27.766853,0.7363281,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.72558594,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8481306923125916,0.334008095964767,0.006202924235711121,0.2857142857142857,53.846876613748506,11.0,11.0,113.99808795411089,6.026093628127617e-23,Rossmann-like NAD(P)-dependent dehydrogenases,True,assigned_and_evaluated +12644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand/metal-binding loop-helix N-caps,False,no_term_above_threshold +12645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Recombinase/integrase N-terminal DNA-binding module,False,no_term_above_threshold +12646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CaMKII hub-domain beta-strand motif,False,no_term_above_threshold +12647,38317,15.741548,0.9770508,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.80908203,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9488888888888887,0.03226091558749277,0.0031014621178555605,,10.401840925853026,0.0,14.0,0.0,1.0,Helix caps and interhelical linkers,True,assigned_and_evaluated +12648,87882,16.217764,0.64697266,Palmitate,keyword,87317,Cleavage on pair of basic residues,0.640625,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.73163779061158,0.09566541738672886,0.002658396101019052,,35.98614117364117,3.0,17.0,11.75570161025304,0.003405638455738345,Post-cleavage N-terminal activation,True,assigned_and_evaluated +12649,83302,19.768023,0.95214844,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.94873047,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9401967133489841,0.21072859486304693,0.004873726185201595,,43.23767623689972,3.0,12.0,51.397413793103446,4.494756659776325e-05,Secondary-structure junction loops,True,assigned_and_evaluated +12650,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical interaction scaffolds,False,no_term_above_threshold +12651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DJ-1/GATase scaffold signal,False,no_term_above_threshold +12652,36886,23.985859,0.9003906,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9003906,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9351378390395733,0.5143319549057255,0.003544528134692069,0.625,145.1059027777778,20.0,20.0,233.80784313725488,6.513624004794376e-47,C-terminal low-complexity/alpha-solenoid marker,True,assigned_and_evaluated +12653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity LysM linkers,False,no_term_above_threshold +12654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical interaction scaffolds,False,no_term_above_threshold +12655,85656,17.297712,0.93408203,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.93359375,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9787301587301588,0.09121405722631769,0.0031014621178555605,,29.410018165685575,1.0,16.0,8.830124407582938,0.17346236752523847,Active-site pocket-rim loops,True,assigned_and_evaluated +12656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PilZ effectors and catalytic helices,False,no_term_above_threshold +12657,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural alpha helix recognition,False,no_term_above_threshold +12658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic acidic loop motif,False,no_term_above_threshold +12659,69819,21.198488,0.7553711,"ATPase, nucleotide binding domain",interpro,69819,"ATPase, nucleotide binding domain",0.7553711,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,16.0,16.0,419.86619718309856,5.004309649898154e-42,Phosphate-binding catalytic core,True,assigned_too_few_test_positives +12660,87149,18.952133,0.7133789,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.7133789,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.6980228161251043,0.026214300491040458,0.012405848471422242,,2.113059864581368,1.0,10.0,15.170737913486006,0.10472231415759618,Core amphipathic alpha-helices,True,assigned_and_evaluated +12661,50338,16.260296,0.8022461,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8017578,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,ABC transporter coupling helix,True,assigned_too_few_test_positives +12662,87832,16.998327,0.7871094,Neuropeptide,keyword,8705,neuropeptide signaling pathway,0.78271484,474,keywords,Neuropeptide,keyword:keywords:Neuropeptide,49.0,2257.0,0.8036176427092576,0.40741730552007704,0.021710234824988923,0.5306122448979592,18.76613997058804,2.0,20.0,9.77393442622951,0.029689988733316203,Sparse short-stretch disordered activations,True,assigned_and_evaluated +12663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix–strand–helix micro-motif,False,no_term_above_threshold +12664,85682,16.937119,0.80908203,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.80908203,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9620430107526882,0.1520314872088167,0.011076650420912717,,13.725402665211972,0.0,17.0,0.0,1.0,Edge beta-strand loop microsegments,True,assigned_and_evaluated +12665,-1,,,,,-1,,,0,,,,,,,,,,,,,,,URO-D internal scaffold helix,False,no_term_above_threshold +12666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity terminal tails,False,no_term_above_threshold +12667,85364,18.366167,0.6953125,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.6953125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,13.0,20.0,195.72550505050506,1.0237613573715068e-27,Periplasmic SBP early beta-strand patch,True,assigned_too_few_test_positives +12668,64003,21.69074,0.9970703,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.8378906,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0000000000000002,1.0,0.003987594151528578,1.0,250.7777777777778,19.0,19.0,130.4617067833698,3.819237356487831e-40,C2H2 zinc-finger linkers,True,assigned_and_evaluated +12669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking loops,False,no_term_above_threshold +12670,36104,19.533684,0.97802734,Rho GTPase-activating protein domain,interpro,25169,pilus,0.8432617,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Beta-strand N-glycosylation hotspot,True,assigned_too_few_test_positives +12671,36104,25.593704,0.9819336,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9819336,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,C-terminal active-site alpha/beta cores,True,assigned_too_few_test_positives +12672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved mid-chain interface segments,False,no_term_above_threshold +12673,36104,24.931004,0.9760742,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9760742,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Active-site-adjacent surface patches,True,assigned_too_few_test_positives +12674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long ordered alpha-helical scaffolds,False,no_term_above_threshold +12675,87852,17.442556,0.89990234,Nucleosome core,keyword,87852,Nucleosome core,0.89990234,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,19.0,0.0,1.0,RG/RGG-rich disordered tails,True,assigned_too_few_test_positives +12676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNR large-subunit GLG motif,False,no_term_above_threshold +12677,82029,25.956167,0.9995117,MFS general substrate transporter like domains,gene3d,88162,Transport,0.62060547,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Paired MFS helix–loop caps,True,assigned_too_few_test_positives +12678,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal IHELxxV/I hotspot,False,no_term_above_threshold +12679,59224,32.76901,0.9736328,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9736328,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9998730158730158,0.9617346938775511,0.0031014621178555605,1.0,310.09074344023327,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Pro/Gly-enriched beta-edge loops,True,assigned_and_evaluated +12680,64475,20.468632,0.99072266,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.95947266,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9923556835321541,0.2684529860159151,0.0057598582188746125,,46.60756841830157,0.0,12.0,0.0,1.0,Active-site phosphate-binding loops,True,assigned_and_evaluated +12681,38317,22.150114,0.8540039,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8540039,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8918412698412699,0.032128861135866264,0.0031014621178555605,,10.359262797664309,0.0,13.0,0.0,1.0,Basic disordered RNA-binding tails,True,assigned_and_evaluated +12682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNAP second subunit motifs,False,no_term_above_threshold +12683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal regulatory tails,False,no_term_above_threshold +12684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix boundary preference,False,no_term_above_threshold +12685,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribosyltransferase catalytic core,False,no_term_above_threshold +12686,48241,15.770957,0.70410156,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.70410156,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,0.0,17.0,0.0,1.0,FHA phosphothreonine binding domain,True,assigned_too_few_test_positives +12687,36977,16.358852,0.9609375,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9082031,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,4.0,18.0,69.00578703703704,5.992741255510842e-07,Conserved kinase C-lobe helix residue,True,assigned_too_few_test_positives +12688,8305,15.995748,0.73535156,fatty acid biosynthetic process,go_bp,8305,fatty acid biosynthetic process,0.73535156,31,go,GO:0006633,go_bp:go:GO:0006633,9.0,2257.0,0.9345591142744167,0.17798282326708562,0.003987594151528578,0.1111111111111111,44.634136901534696,0.0,17.0,0.0,1.0,Transporter TM helix signature,True,assigned_and_evaluated +12689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved alpha-helix packing signal,False,no_term_above_threshold +12690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain activation,False,no_term_above_threshold +12691,85656,19.947416,0.94189453,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7817383,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9798095238095237,0.08858020283212098,0.0031014621178555605,,28.560788256013865,0.0,15.0,0.0,1.0,Catalytic-adjacent hinge loops,True,assigned_and_evaluated +12692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Cys-rich cofactor-binding loops,False,no_term_above_threshold +12693,43624,20.360184,0.8911133,Homedomain-like superfamily,interpro,29166,zinc ion binding,0.7558594,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8882195448460508,0.07599427621358934,0.007089056269384138,,10.719942588379446,4.0,16.0,21.951767304860088,5.0343468510264895e-05,Short amphipathic helical hinges,True,assigned_and_evaluated +12694,25169,23.273323,0.88378906,pilus,go_cc,25169,pilus,0.88378906,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,12.0,18.0,368.03086419753083,4.383686256206937e-29,Beta-edge strand–turn motifs,True,assigned_and_evaluated +12695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HAMP domain coupling modules,False,no_term_above_threshold +12696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polysaccharide deacetylases and hydrolases,False,no_term_above_threshold +12697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor hairpin,False,no_term_above_threshold +12698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,α/β catalytic barrel core,False,no_term_above_threshold +12699,37894,29.22192,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.98046875,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,9.0,709.7738095238095,4.424699527134814e-26,SDR substrate pocket helix,True,assigned_too_few_test_positives +12700,45288,15.56465,0.98339844,CheY-like superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7133789,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,14.0,14.0,462.17829457364337,1.5319912053906924e-37,REC phosphoacceptor pocket,True,assigned_too_few_test_positives +12701,88158,16.236485,0.7470703,Translocation,keyword,87149,Amphibian defense peptide,0.71240234,68,keywords,Translocation,keyword:keywords:Translocation,18.0,2257.0,0.4566770879857079,0.007975188303057155,0.007975188303057155,,1.0,0.0,10.0,0.0,1.0,SRP54 M-domain signal-binding helices,True,assigned_and_evaluated +12702,86130,17.342371,0.7636719,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,86130,Zn(2)-C6 fungal-type DNA-binding domain,0.7636719,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.7053968253968255,0.03690945737545388,0.0031014621178555605,,11.900663613771345,0.0,16.0,0.0,1.0,Conserved amphipathic helical cores,True,assigned_and_evaluated +12703,87326,20.32949,0.6508789,Coiled coil,keyword,87326,Coiled coil,0.6508789,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7062222728968863,0.13240366201320514,0.03943287549844927,,3.357697361391056,12.0,18.0,8.40501867907239,1.4878219757400116e-09,Soluble α-helical scaffolds,True,assigned_and_evaluated +12704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic-Pro-aromatic active-site loops,False,no_term_above_threshold +12705,47531,21.157495,0.95410156,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.95410156,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,13.0,13.0,252.6313559322034,1.7372122270136458e-31,Nucleotide/sugar-phosphate alpha/beta enzymes,True,assigned_too_few_test_positives +12706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,2H/HIT RNA phosphoesterases,False,no_term_above_threshold +12707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rhamnogalacturonate lyase β-strand motif,False,no_term_above_threshold +12708,49121,16.811314,0.8100586,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.8100586,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,1.0,18.0,54.29963570127505,0.030816156185325745,PAS sensory caps and linkers,True,assigned_too_few_test_positives +12709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrophobic interface block,False,no_term_above_threshold +12710,55054,28.481796,0.9692383,HAD superfamily,interpro,55054,HAD superfamily,0.9692383,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.7961811722912966,0.3627908939384349,0.002215330084182543,0.4,163.76380952380953,15.0,15.0,334.9494382022472,4.957857297918448e-38,Asp-dependent hydrolase cap helix,True,assigned_and_evaluated +12711,30107,17.95268,0.8310547,nickel cation binding,go_mf,30107,nickel cation binding,0.8310547,31,go,GO:0016151,go_mf:go:GO:0016151,20.0,2257.0,0.9227313366115333,0.8113159705372821,0.008861320336730172,0.85,91.55700727513229,0.0,14.0,0.0,1.0,Conserved catalytic cofactor-binding cores,True,assigned_and_evaluated +12712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix bundle core,False,no_term_above_threshold +12713,64146,27.79562,0.7558594,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7558594,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.7539328073048484,0.13958703911604228,0.007975188303057155,0.05555555555555555,17.502663738050416,2.0,20.0,6.683968609865471,0.0589465065467063,AAA+ N-terminal helix motif,True,assigned_and_evaluated +12714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helix detector,False,no_term_above_threshold +12715,59211,19.489325,0.9716797,Nucleotide-diphospho-sugar transferases,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.93847656,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9705734767025089,0.3476978503316154,0.011076650420912717,0.8,31.390161927938234,0.0,15.0,0.0,1.0,APE-like EEP catalytic motifs,True,assigned_and_evaluated +12716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nonpolar microenvironment detector,False,no_term_above_threshold +12717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MFP periplasmic YT...APxxG motif,False,no_term_above_threshold +12718,50806,20.990843,0.9379883,"Homeobox, conserved site",interpro,37071,Homeodomain,0.87939453,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,17.0,0.0,1.0,Low-complexity loops and helix caps,True,assigned_too_few_test_positives +12719,46078,19.581757,0.98583984,Armadillo-like helical,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9609375,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,18.0,18.0,130.74780701754386,3.9193799829466193e-38,HEAT/ARM alpha-solenoid helices,True,assigned_too_few_test_positives +12720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic alpha/beta core activation,False,no_term_above_threshold +12721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory flanks of catalytic cores,False,no_term_above_threshold +12722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix aromatic anchors,False,no_term_above_threshold +12723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal nuclease/phosphodiesterase domains,False,no_term_above_threshold +12724,39958,21.486938,0.8227539,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.8227539,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9955575299866726,0.27234126984126983,0.002658396101019052,,102.44570767195766,0.0,13.0,0.0,1.0,PAPS-dependent sulfotransferase catalytic domain,True,assigned_and_evaluated +12725,85669,17.03422,0.9760742,3.40.50.2300,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.87158203,62,gene3d,3.40.50.2300,gene3d:gene3d:3.40.50.2300,5.0,2257.0,0.8832149200710481,0.6099668755406461,0.002215330084182543,0.6,275.3390476190477,16.0,16.0,254.79059829059833,1.347899219907049e-38,Active-site-proximal acidic motifs,True,assigned_and_evaluated +12726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic assembly interface motifs,False,no_term_above_threshold +12727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AMT/Rh C-terminal helix-tail signature,False,no_term_above_threshold +12728,87108,17.046824,0.64746094,ANK repeat,keyword,87108,ANK repeat,0.64746094,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.6033264136022143,0.01434028714978404,0.003987594151528578,,3.5962253441180643,0.0,16.0,0.0,1.0,Ty1/copia reverse transcriptase domain,True,assigned_and_evaluated +12729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity regulatory helical tails,False,no_term_above_threshold +12730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cleft loops,False,no_term_above_threshold +12731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-solenoid spike shaft repeats,False,no_term_above_threshold +12732,38873,19.516798,0.93115234,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.85058594,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8905861456483126,0.12007110899249271,0.002215330084182543,,54.20009859921121,1.0,16.0,10.707794540229886,0.14516458382097489,NTPase-adjacent basic amphipathic segment,True,assigned_and_evaluated +12733,85649,35.822296,0.86376953,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.85791016,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8031898330154529,0.5290756170976078,0.0101905183872397,0.6086956521739131,51.91842033866524,8.0,18.0,49.16182230467944,3.74439164513407e-12,AOR–Cas12 loop/β-strand motif,True,assigned_and_evaluated +12734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical membrane anchors,False,no_term_above_threshold +12735,87276,29.54157,0.6269531,Cell membrane,keyword,88161,Transmembrane helix,0.6142578,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6864247893768892,0.41570462799511376,0.11120957022596367,0.4063745019920319,3.738029264481959,17.0,19.0,7.341743086038797,8.654145245761993e-14,Transmembrane alpha-helix motif,True,assigned_and_evaluated +12736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical nucleic-acid interfaces,False,no_term_above_threshold +12737,48241,24.72698,0.9848633,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9848633,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,17.0,18.0,365.6410533910534,9.425704243737979e-43,Ligand-facing beta hairpin motif,True,assigned_too_few_test_positives +12738,64058,24.0728,0.98535156,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.97265625,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9944748742118337,0.4019244377383165,0.006202924235711121,0.21428571428571427,64.79596114109859,4.0,16.0,28.49952198852772,1.829373085018963e-05,REC/Rossmann N-terminal hydrophobe,True,assigned_and_evaluated +12739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interface motifs,False,no_term_above_threshold +12740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic polar-aromatic loops,False,no_term_above_threshold +12741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LRAT/PLAAT global activation,False,no_term_above_threshold +12742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-rich tails and F420 motif,False,no_term_above_threshold +12743,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged linear motifs,False,no_term_above_threshold +12744,50806,16.556948,0.7739258,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.7739258,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,12.0,0.0,1.0,Extended polyanion-binding interfaces,True,assigned_too_few_test_positives +12745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase active-site clefts,False,no_term_above_threshold +12746,37341,28.490322,0.9951172,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9819336,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9998339146321209,0.9839976681196276,0.011962782454585734,1.0,82.25491618318517,0.0,17.0,0.0,1.0,Acidic/Gly beta-strand starts,True,assigned_and_evaluated +12747,49045,18.175894,0.9980469,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.77685547,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,14.0,18.0,421.5626262626263,3.5774602549207543e-35,Beta-propeller loop-to-strand junctions,True,assigned_too_few_test_positives +12748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed beta-strand edges,False,no_term_above_threshold +12749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal DNA-binding helical hairpins,False,no_term_above_threshold +12750,27735,15.876812,0.70214844,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.70214844,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.6750163776161087,0.13771352577066953,0.011519716437749225,0.15384615384615385,11.954593371707736,12.0,20.0,27.141578148710167,3.2541897466837145e-15,Fungal N-terminal activation IDRs,True,assigned_and_evaluated +12751,88058,24.18204,0.6479492,Signal,keyword,88058,Signal,0.6479492,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6357897876006494,0.11169746155827305,0.09127159946832078,,1.2237920909564188,4.0,20.0,1.4409909365558913,0.4670478563492871,Ser/Pro-biased low complexity regions,True,assigned_and_evaluated +12752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pilin TM C-terminal boundary,False,no_term_above_threshold +12753,37690,23.557787,0.9682617,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9589844,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9791746031746033,0.08510951393128373,0.0031014621178555605,,27.44173899184391,0.0,11.0,0.0,1.0,Dinucleotide-binding and phosphotransfer motifs,True,assigned_and_evaluated +12754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA strand-separation wedge-core,False,no_term_above_threshold +12755,45317,18.241959,0.95751953,"Six-bladed beta-propeller, TolB-like",interpro,87697,Knottin,0.7553711,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,13.0,13.0,764.3717948717948,7.661200220716665e-38,Gly/Pro-rich beta-loop signature,True,assigned_too_few_test_positives +12756,46274,18.347734,0.88427734,Ribonuclease H-like superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.69091797,72,ip,IPR012337,interpro:ip:IPR012337,38.0,2257.0,0.8847453808021631,0.2333380629412171,0.016836508639787327,0.05263157894736842,13.859052843640184,9.0,14.0,155.80400696864112,1.4719088678951593e-18,Catalytic strand-helix junction,True,assigned_and_evaluated +12757,88263,19.710659,0.6303711,Zinc-finger,keyword,88263,Zinc-finger,0.6303711,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.5989072378460867,0.0537763193401158,0.014621178555604785,0.030303030303030304,3.677974325777011,18.0,20.0,23.452316433566434,1.5541247365923982e-23,Charged IDR/helical scaffolds,True,assigned_and_evaluated +12758,37690,18.140354,0.9501953,Ankyrin repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9448242,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9603809523809523,0.04366755640560127,0.0031014621178555605,,14.07966782963458,0.0,18.0,0.0,1.0,Hydrophobic helix packing interfaces,True,assigned_and_evaluated +12759,49061,18.328712,0.70703125,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.70703125,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8941229250785105,0.1787509032469274,0.012405848471422242,,14.408599593868399,0.0,20.0,0.0,1.0,Beta-propeller and jellyroll scaffolds,True,assigned_and_evaluated +12760,36104,21.615131,0.9375,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9375,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Acidic aromatic glycan binding clefts,True,assigned_too_few_test_positives +12761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-dependent catalytic cores,False,no_term_above_threshold +12762,64155,23.774998,0.9848633,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9604492,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,2.0,18.0,30.811886304909557,0.003317090402528919,Internal basic DNA-binding segments,True,assigned_too_few_test_positives +12763,63774,15.642798,0.9584961,RNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.8286133,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,19.0,0.0,1.0,Exposed beta-sheet binding patches,True,assigned_too_few_test_positives +12764,47531,17.448225,0.8774414,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.8774414,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,1.0,17.0,14.860667996011966,0.10666156880124364,N-terminal active-site wall,True,assigned_too_few_test_positives +12765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural alpha helices,False,no_term_above_threshold +12766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PASTA repeats in bacterial STPKs,False,no_term_above_threshold +12767,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage adsorption fibers and depolymerases,False,no_term_above_threshold +12768,85675,16.555159,0.8847656,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.87060547,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,13.0,15.0,474.0507645259939,6.098943990571642e-34,VWA domain interaction surfaces,True,assigned_too_few_test_positives +12769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RadA C-terminal beta/alpha block,False,no_term_above_threshold +12770,50869,19.244415,0.8339844,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.8339844,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,17.0,0.0,1.0,Cas10 domain-wide activation,True,assigned_too_few_test_positives +12771,36535,16.23397,0.9394531,Protein kinase domain,interpro,37446,F-box domain,0.9301758,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.947196261682243,0.9004430660168364,0.004430660168365086,0.9,203.23,18.0,18.0,89.79066265060241,2.921620089201569e-35,Kinase C-lobe helix-loop cap,True,assigned_and_evaluated +12772,36449,17.876766,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,13.0,18.0,768.921626984127,4.6836628481461014e-36,Membrane-interface helix caps,True,assigned_too_few_test_positives +12773,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UvrC linker peaks near GIY-YIG,False,no_term_above_threshold +12774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered signaling scaffold linkers,False,no_term_above_threshold +12775,81685,19.698923,0.96533203,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96240234,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9949146250927988,0.9233780760626398,0.005316792202038104,0.9166666666666666,173.67202647278148,19.0,19.0,85.66235632183908,8.858414841848649e-37,Kinase ATP pocket β-strands,True,assigned_and_evaluated +12776,39958,22.435932,0.9785156,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.9785156,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9977417444098919,0.3807590557590558,0.002658396101019052,,143.22886480803146,2.0,20.0,47.31825396825397,0.0014475794605876284,Domain core recognition hotspots,True,assigned_and_evaluated +12777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M18 PRLDN/WDNR helix-cap motif,False,no_term_above_threshold +12778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP-dependent enzyme fold,False,no_term_above_threshold +12779,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic regulatory interaction regions,False,no_term_above_threshold +12780,64317,15.8216095,0.90527344,"Knottin, scorpion toxin-like superfamily",interpro,64317,"Knottin, scorpion toxin-like superfamily",0.90527344,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,17.0,0.0,1.0,Short aromatic acidic loop motif,True,assigned_too_few_test_positives +12781,43583,16.100409,0.9638672,"Peptidase S1, PA clan",interpro,36354,RNA recognition motif domain,0.80078125,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,0.9817453250222619,0.23359487841907364,0.004873726185201595,0.18181818181818182,47.9294218719863,8.0,9.0,370.6045066045066,2.1172081681009995e-20,Gly/Ser-rich beta-turn loops,True,assigned_and_evaluated +12782,45317,20.624985,0.8955078,"Six-bladed beta-propeller, TolB-like",interpro,45317,"Six-bladed beta-propeller, TolB-like",0.8955078,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,8.0,16.0,382.1858974358974,1.9346524532341778e-19,Ca2+-stabilized beta-propeller repeats,True,assigned_too_few_test_positives +12783,64016,37.377216,0.8984375,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.8984375,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8520634920634921,0.25258681230578184,0.0031014621178555605,0.5714285714285714,81.44120505344995,12.0,13.0,204.59022018873318,2.3752269866491593e-27,Disulfide redox and proteostasis,True,assigned_and_evaluated +12784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHHC-biased membrane/cysteine signature,False,no_term_above_threshold +12785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane low-complexity linkers,False,no_term_above_threshold +12786,80926,18.213491,0.79589844,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.7758789,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.9155868641162759,0.140028630942441,0.0057598582188746125,,24.311124618237642,1.0,19.0,5.020715789473684,0.2873479223675574,Aromatic helical binding face,True,assigned_and_evaluated +12787,88058,23.996859,0.6147461,Signal,keyword,88058,Signal,0.6147461,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6272774824499534,0.16947636134818705,0.09127159946832078,0.019417475728155338,1.856835667780865,17.0,18.0,6.804679422625042,9.227806822550483e-14,N-terminal signal and transit peptides,True,assigned_and_evaluated +12788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,beta-strand i/i+2 face detector,False,no_term_above_threshold +12789,64058,21.789944,0.7270508,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7236328,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8549455448697535,0.6220876629541734,0.006202924235711121,0.6428571428571429,100.28941823482639,17.0,17.0,113.99808795411089,4.31985177778818e-35,MDR C-terminal helix–strand motif,True,assigned_and_evaluated +12790,84753,21.518305,0.6982422,3.30.420.40,gene3d,84753,3.30.420.40,0.6982422,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,13.0,17.0,316.6147875816993,5.142619432509102e-31,ASKHA NTP-binding domain,True,assigned_too_few_test_positives +12791,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease catalytic and nucleic-acid-binding surfaces,False,no_term_above_threshold +12792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic targeting segments,False,no_term_above_threshold +12793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase core,False,no_term_above_threshold +12794,87326,21.31238,0.6118164,Coiled coil,keyword,87326,Coiled coil,0.6118164,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.5662625938057133,0.06505348469332099,0.03943287549844927,,1.64972713430141,11.0,19.0,7.299095168668129,6.365830407590611e-08,Charge-enriched helical scaffolds,True,assigned_and_evaluated +12795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alternating amphipathic β-strands,False,no_term_above_threshold +12796,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact folded domain cores,False,no_term_above_threshold +12797,37071,25.67388,1.0,Homeodomain,interpro,80926,Homeodomain-like,0.84765625,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,14.0,14.0,206.30103806228374,1.2714014319586377e-32,Homeobox-flanking disordered activation tails,True,assigned_too_few_test_positives +12798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed polar segments,False,no_term_above_threshold +12799,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and arms,False,no_term_above_threshold +12800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic helix-packing signal,False,no_term_above_threshold +12801,37468,16.301043,0.8623047,"Zinc finger, RING-type",interpro,87384,DNA-binding,0.6176758,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,19.0,0.0,1.0,DHp/HTH structural alpha helices,True,assigned_too_few_test_positives +12802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic coiled-coil heptad faces,False,no_term_above_threshold +12803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor-effector coupling helices,False,no_term_above_threshold +12804,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-rich LU/CRD domains,False,no_term_above_threshold +12805,81858,17.401487,0.75439453,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.75439453,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,N-terminal TM1 boundary transition,True,assigned_too_few_test_positives +12806,25169,16.810081,0.7006836,pilus,go_cc,25169,pilus,0.7006836,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8983126110124334,0.54377639935017,0.002215330084182543,0.8,245.46066666666675,0.0,19.0,0.0,1.0,C-terminal TPR capping helix,True,assigned_and_evaluated +12807,46581,18.55328,0.9916992,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9916992,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,12.0,19.0,109.46328029375765,1.5150446587225661e-22,RNA-binding helices and FG repeats,True,assigned_too_few_test_positives +12808,64058,18.298937,0.9121094,NAD(P)-binding domain superfamily,interpro,88153,Transferase,0.6738281,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9780109547162601,0.2098428568949313,0.006202924235711121,,33.82966628656142,0.0,12.0,0.0,1.0,Active-site beta-strand anchors,True,assigned_and_evaluated +12809,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PARP and disordered-region activation,False,no_term_above_threshold +12810,87149,17.732588,0.6953125,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6953125,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.678515349612254,0.021437135782761144,0.012405848471422242,,1.7279862664889964,0.0,11.0,0.0,1.0,Helix-loop boundary interfaces,True,assigned_and_evaluated +12811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble α/β core scaffold,False,no_term_above_threshold +12812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HIGH/HxH catalytic N-termini,False,no_term_above_threshold +12813,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal propeptides and linkers,False,no_term_above_threshold +12814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha-helices,False,no_term_above_threshold +12815,47529,28.63825,0.9785156,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9785156,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9920236501561803,0.6352326392056895,0.007089056269384138,0.5,89.60750416795258,18.0,18.0,77.32944228274968,4.066396380554961e-34,Ig-like aromatic β-strand anchor,True,assigned_and_evaluated +12816,72011,20.372545,0.98876953,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.94091797,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,13.0,0.0,1.0,N-terminal targeting/accessory segments,True,assigned_too_few_test_positives +12817,27918,18.498661,0.63183594,DNA-binding transcription factor activity,go_mf,27918,DNA-binding transcription factor activity,0.63183594,363,go,GO:0003700,go_mf:go:GO:0003700,21.0,2257.0,0.631005622284692,0.10687925740310801,0.00930438635356668,0.14285714285714285,11.486975426610229,7.0,7.0,37.008690254500316,2.2320107305632787e-11,Plant TF N-terminal IDR activation,True,assigned_and_evaluated +12818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting and disorder,False,no_term_above_threshold +12819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory ectodomains and cytosolic N-termini,False,no_term_above_threshold +12820,36914,15.687442,0.98339844,Glycosyltransferase 2-like,interpro,45288,CheY-like superfamily,0.97998047,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,15.0,0.0,1.0,REC α4 helical output face,True,assigned_too_few_test_positives +12821,58239,23.569952,0.6533203,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6533203,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6685160126296797,0.2587575249695666,0.017722640673460344,0.225,14.600393346407797,17.0,17.0,35.851473241130485,1.1097904818074523e-26,Noncatalytic helical coupling inserts,True,assigned_and_evaluated +12822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved LeuRS catalytic helices,False,no_term_above_threshold +12823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic P/T-rich low-complexity linkers,False,no_term_above_threshold +12824,64026,18.166595,0.7285156,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.7285156,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7398563601362358,0.03353190767257398,0.002658396101019052,,12.61358593616658,18.0,18.0,169.3778409090909,4.210587660281294e-40,"Small-residue i,i+4 helix motifs",True,assigned_and_evaluated +12825,50338,17.55543,0.9277344,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6254883,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane helix packing residues,True,assigned_too_few_test_positives +12826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved binding interfaces,False,no_term_above_threshold +12827,50869,17.084038,0.98876953,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.98876953,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,8.0,0.0,1.0,Acyltransferase Motif II EGTR loop,True,assigned_too_few_test_positives +12828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered linkers and domain-edge anchors,False,no_term_above_threshold +12829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prion-like low-complexity IDRs,False,no_term_above_threshold +12830,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site wall alpha-helix,False,no_term_above_threshold +12831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved loop-turn hotspots,False,no_term_above_threshold +12832,37894,18.463028,0.8417969,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8417969,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,4.0,15.0,189.27301587301588,1.0022665949616536e-08,Coil-helix boundaries and N-caps,True,assigned_too_few_test_positives +12833,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain-onset region,False,no_term_above_threshold +12834,36876,15.879474,0.99902344,Cytochrome P450,interpro,30838,heme binding,0.7524414,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,389.6797385620915,6.157114732498076e-44,P450 catalytic domain signature,True,assigned_and_evaluated +12835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic membrane interface loops,False,no_term_above_threshold +12836,45324,19.583502,0.9814453,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9814453,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.999822380106572,0.9266666666666665,0.002215330084182543,1.0,418.2973333333333,15.0,18.0,455.81804281345563,1.779622673141242e-38,Acidic disordered loops and linkers,True,assigned_and_evaluated +12837,64381,20.151676,0.95214844,Helix-loop-helix DNA-binding domain superfamily,interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.95214844,41,ip,IPR036638,interpro:ip:IPR036638,,,,,,,,0.0,19.0,0.0,1.0,HAMP-DHp junction helix,True,assigned_too_few_test_positives +12838,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal ordered arm,False,no_term_above_threshold +12839,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic domain,False,no_term_above_threshold +12840,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Integrase domain segment recognizer,False,no_term_above_threshold +12841,82029,21.97861,0.83251953,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.83203125,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,15.0,188.0788643533123,2.6763117326797814e-34,C-terminal transmembrane bundle,True,assigned_too_few_test_positives +12842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic helical assembly regions,False,no_term_above_threshold +12843,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site gating loops,False,no_term_above_threshold +12844,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-coil boundary glycine caps,False,no_term_above_threshold +12845,38873,15.818669,0.82958984,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7402344,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7903641207815275,0.10961629076383175,0.002215330084182543,,49.48079365079366,13.0,19.0,117.22217180883243,5.782337261860972e-25,Walker-adjacent NTPase helix/loop,True,assigned_and_evaluated +12846,64148,31.926105,0.9086914,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8857422,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9615963501246413,0.3990185596595687,0.008418254319893664,0.15789473684210525,47.39920469219192,10.0,18.0,49.436981757877284,2.8491089759767116e-15,Helix-capping hinge linkers,True,assigned_and_evaluated +12847,49061,17.462978,0.8745117,WD40/YVTN repeat-like-containing domain superfamily,interpro,87413,Disulfide bond,0.6347656,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8701932320707557,0.058257067236037394,0.012405848471422242,,4.695935741133443,0.0,15.0,0.0,1.0,TilS C-terminal conserved site,True,assigned_and_evaluated +12848,82029,31.578297,0.8574219,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.8544922,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,16.0,188.0788643533123,1.615494529537867e-36,12-TM MFS transporter signature,True,assigned_too_few_test_positives +12849,87326,28.662779,0.6323242,Coiled coil,keyword,87326,Coiled coil,0.6323242,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6278089887640449,0.11040613456288291,0.03943287549844927,,2.7998499517800757,6.0,18.0,4.202509339536195,0.0034695315296623262,Hydrophobic coiled-coil interfaces,True,assigned_and_evaluated +12850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged nucleic acid binding grooves,False,no_term_above_threshold +12851,38654,17.12189,0.90283203,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.89697266,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,16.0,0.0,1.0,AWS-SET boundary SAM-binding loop,True,assigned_too_few_test_positives +12852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader helix/loop,False,no_term_above_threshold +12853,64168,22.168978,0.8769531,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.8769531,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.7963587921847247,0.48421946536700633,0.002215330084182543,0.6,218.57666666666668,18.0,18.0,334.9494382022472,3.408992422977286e-45,N-terminal helical cap,True,assigned_and_evaluated +12854,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA polymerase PHP LHxHxx motif,False,no_term_above_threshold +12855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane acyltransferase catalytic core,False,no_term_above_threshold +12856,87697,25.45262,0.95410156,Knottin,keyword,87413,Disulfide bond,0.70214844,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9954567524450302,0.6060416709724334,0.017279574656623838,1.0,35.072719266276465,0.0,17.0,0.0,1.0,EGF C2–C3 loop motif,True,assigned_and_evaluated +12857,37894,25.49586,0.99853516,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.99853516,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,14.0,659.0756802721089,2.5820292060120413e-36,SDR C-terminal tail,True,assigned_too_few_test_positives +12858,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal HMA and tails activation,False,no_term_above_threshold +12859,50869,18.72855,0.9848633,"DNA binding HTH domain, AraC-type",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9448242,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,1.0,15.0,61.149743589743586,0.027437523085096498,N-box-adjacent ATP-lid hinge,True,assigned_too_few_test_positives +12860,45288,21.463745,0.9838867,CheY-like superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.65527344,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,17.0,17.0,462.17829457364337,3.827449248759242e-45,REC/AAA+ core beta-strand,True,assigned_too_few_test_positives +12861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic residue detector,False,no_term_above_threshold +12862,81799,16.214836,0.8339844,1.10.8.60,gene3d,45551,SKP1/BTB/POZ domain superfamily,0.72753906,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,11.0,15.0,424.48608414239476,1.0747467023988119e-27,Post-P-loop helical interface,True,assigned_too_few_test_positives +12863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic beta-loop Arg/His motifs,False,no_term_above_threshold +12864,49121,20.332094,0.94921875,"Signal transduction response regulator, C-terminal effector",interpro,87566,Homeobox,0.81591797,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,12.0,0.0,1.0,ABC C-loop hydrophobic anchor,True,assigned_too_few_test_positives +12865,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HotDog/MaoC acyl-thioester scaffold,False,no_term_above_threshold +12866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic anchors and enzyme cores,False,no_term_above_threshold +12867,64148,37.30374,0.9814453,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9296875,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9905931047457787,0.34152606288859233,0.008418254319893664,0.05263157894736842,40.56970125997647,6.0,20.0,26.695970149253732,1.3189220585286424e-07,Helix-to-strand transition motif,True,assigned_and_evaluated +12868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CpcD-like motif recognition,False,no_term_above_threshold +12869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix packing signatures,False,no_term_above_threshold +12870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBM-like C-terminal beta-sandwich,False,no_term_above_threshold +12871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic tails and P-loops,False,no_term_above_threshold +12872,83267,17.07414,0.98876953,DNA-binding pseudobarrel domain,gene3d,37446,F-box domain,0.89404297,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,18.0,0.0,1.0,Plant-skewed noncatalytic recognition surfaces,True,assigned_too_few_test_positives +12873,87355,15.989745,0.74365234,Cuticle,keyword,87355,Cuticle,0.74365234,30,keywords,Cuticle,keyword:keywords:Cuticle,,,,,,,,3.0,11.0,271.00454545454545,3.1130391228153146e-07,Disordered low-complexity linkers,True,assigned_too_few_test_positives +12874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal oligomerization/anchoring segment,False,no_term_above_threshold +12875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure cap/kink detector,False,no_term_above_threshold +12876,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThyX/FDTS ligand binding region detector,False,no_term_above_threshold +12877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP transpeptidase helix-cap motif,False,no_term_above_threshold +12878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved loop–helix interface motifs,False,no_term_above_threshold +12879,64596,32.961735,1.0,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,interpro,59218,Metallo-dependent phosphatase-like,0.9819336,38,ip,IPR036866,interpro:ip:IPR036866,,,,,,,,12.0,12.0,614.6494845360825,8.092433897031415e-34,MBL HxH/HxHxD active site,True,assigned_too_few_test_positives +12880,85664,17.958693,0.9790039,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8520508,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,20.0,20.0,331.22777777777776,1.2127040143295405e-49,His-centered donor-binding loop,True,assigned_too_few_test_positives +12881,36776,19.780603,0.9873047,SANT/Myb domain,interpro,87384,DNA-binding,0.6845703,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.973567303420702,0.052049173825785514,0.002658396101019052,,19.57916422079965,0.0,19.0,0.0,1.0,Nucleic acid recognition helix,True,assigned_and_evaluated +12882,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transcriptional IDRs and helical leucines,False,no_term_above_threshold +12883,87413,18.779867,0.6020508,Disulfide bond,keyword,87413,Disulfide bond,0.6020508,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.526697899172044,0.09233267993107667,0.0717766947275144,0.012345679012345678,1.2863880160767904,9.0,16.0,6.6528094624082525,2.7661839272486314e-06,Amphipathic β‑strand edge motif,True,assigned_and_evaluated +12884,63774,16.020166,0.9794922,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9790039,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,9.0,0.0,1.0,Conserved beta-strand core hydrophobes,True,assigned_too_few_test_positives +12885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar beta-solenoid junction motif,False,no_term_above_threshold +12886,85649,30.325933,0.84228516,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8408203,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7856447783270406,0.2716311797163007,0.0101905183872397,0.21739130434782608,26.655285766073504,14.0,14.0,110.61410018552876,7.27210921345717e-29,SAM MTase glycine/acidic loop,True,assigned_and_evaluated +12887,46079,15.905564,0.6015625,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.6015625,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.5680104209515974,0.011939577001052411,0.0057598582188746125,,2.0728942531827146,16.0,16.0,93.1578125,1.077826237289177e-31,Alpha-solenoid helical scaffolds,True,assigned_and_evaluated +12888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensory-domain capping beta-strands,False,no_term_above_threshold +12889,47529,28.757282,0.91308594,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.91308594,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9316432396251674,0.6252589587842172,0.007089056269384138,0.6875,88.20059187349864,12.0,17.0,54.58548867017625,2.983590382420305e-19,Secreted distal acidic/polar loops,True,assigned_and_evaluated +12890,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular aromatic/acidic motif peaks,False,no_term_above_threshold +12891,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM juxtamembrane interface regions,False,no_term_above_threshold +12892,50763,17.909182,0.9746094,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.9355469,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,17.0,0.0,1.0,Helix N-cap boundary motif,True,assigned_too_few_test_positives +12893,30311,15.558068,0.80322266,glycosyltransferase activity,go_mf,30311,glycosyltransferase activity,0.80322266,75,go,GO:0016757,go_mf:go:GO:0016757,,,,,,,,4.0,18.0,47.31825396825396,2.6487149687153166e-06,Polybasic amphipathic membrane tail,True,assigned_too_few_test_positives +12894,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral glycoprotein ectodomains,False,no_term_above_threshold +12895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity regulatory IDRs,False,no_term_above_threshold +12896,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed helix/beta-turn caps,False,no_term_above_threshold +12897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane contact-site trafficking scaffolds,False,no_term_above_threshold +12898,36104,18.439777,0.8598633,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8598633,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,SWIM-type zinc finger motif,True,assigned_too_few_test_positives +12899,52236,17.687376,0.98876953,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98535156,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,7.0,18.0,86.83874323761964,2.237375140136008e-12,Conserved small-residue helical packing,True,assigned_too_few_test_positives +12900,85712,18.51584,0.71533203,3.40.630.30,gene3d,85712,3.40.630.30,0.71533203,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,9.0,16.0,159.69910714285714,1.960874252210484e-18,Hydrophobic transferase core motifs,True,assigned_too_few_test_positives +12901,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DG-centered short structured motif,False,no_term_above_threshold +12902,36104,21.385857,0.9580078,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9580078,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,9.0,0.0,1.0,Cobalamin adenosyltransferase central helix,True,assigned_too_few_test_positives +12903,48255,16.364952,0.7685547,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.7685547,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,11.0,11.0,340.69142857142856,3.4716447470220033e-28,Rossmann-like NTP-binding catalytic cores,True,assigned_too_few_test_positives +12904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop hotspots,False,no_term_above_threshold +12905,85682,27.364822,0.75878906,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.75878906,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7547132616487455,0.4264359508211967,0.011076650420912717,0.48,38.49863764013763,14.0,14.0,102.26586620926243,2.160832948637194e-28,Cofactor-binding alpha/beta cores,True,assigned_and_evaluated +12906,50806,21.30182,0.75439453,"Homeobox, conserved site",interpro,37071,Homeodomain,0.7138672,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane interface helix signature,True,assigned_too_few_test_positives +12907,49045,17.726952,0.93603516,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.85009766,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,2.0,19.0,57.05358851674641,0.0010015611849919757,Trp-centered beta-propeller loop motif,True,assigned_too_few_test_positives +12908,63774,26.025885,0.99072266,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.97802734,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,15.0,18.0,152.4054192229039,2.7678864605411957e-31,Nuclear RNA-binding C-terminal IDR activation,True,assigned_too_few_test_positives +12909,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TBDT periplasmic plug domain,False,no_term_above_threshold +12910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic polyanion-binding active-site loop,False,no_term_above_threshold +12911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet turn/junction motif,False,no_term_above_threshold +12912,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical appendages,False,no_term_above_threshold +12913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop connectors,False,no_term_above_threshold +12914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal lid helix and linker,False,no_term_above_threshold +12915,37468,17.70819,0.93408203,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.8696289,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,15.0,0.0,1.0,Downstream Gly/Pro patch activation,True,assigned_too_few_test_positives +12916,85682,30.9415,0.77685547,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.77685547,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9382078853046596,0.7247321772777282,0.011076650420912717,0.88,65.4288209646333,15.0,15.0,102.26586620926243,2.302639508687674e-30,N-terminal Rossmann β-loop-α scaffold,True,assigned_and_evaluated +12917,88263,43.169582,0.9526367,Zinc-finger,keyword,29166,zinc ion binding,0.9169922,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9711548942664051,0.19099675600316496,0.014621178555604785,,13.063020554519495,3.0,18.0,4.343021561771561,0.049817725872857106,Zinc/acidic metal-binding micro-motifs,True,assigned_and_evaluated +12918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-protein partner-binding helices,False,no_term_above_threshold +12919,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SF1 helicase core motif,False,no_term_above_threshold +12920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MutS2/Hsp70 mid-domain interface,False,no_term_above_threshold +12921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short cationic bioactive peptides,False,no_term_above_threshold +12922,47717,20.219255,0.99853516,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6191406,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,12.0,14.0,234.42070773263433,1.2754680428774966e-27,M17 aminopeptidase N-terminal motif,True,assigned_too_few_test_positives +12923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-polar flexible loops,False,no_term_above_threshold +12924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DH helical bundle enrichment,False,no_term_above_threshold +12925,49045,15.943178,0.95947266,Kelch-type beta propeller,interpro,88009,Repeat,0.6347656,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,10.0,0.0,1.0,Repeated polar interaction faces,True,assigned_too_few_test_positives +12926,37007,26.199085,0.97802734,Metallo-beta-lactamase,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.97265625,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,7.0,14.0,414.03472222222223,2.3149542919897163e-17,Metallohydrolase scaffold activation,True,assigned_too_few_test_positives +12927,87489,20.776087,0.73828125,GPI-anchor,keyword,87489,GPI-anchor,0.73828125,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.7024761904761906,0.03510559740067937,0.0031014621178555605,,11.319047619047618,3.0,20.0,22.08185185185185,0.0005820446848073517,N-terminal Sec signal peptides,True,assigned_and_evaluated +12928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial chorismate synthase AroC,False,no_term_above_threshold +12929,85675,19.1525,0.9501953,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9272461,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,16.0,18.0,486.20591233435266,8.08865864245789e-42,VWFA MIDAS-like coordination loop,True,assigned_too_few_test_positives +12930,63831,15.907296,0.8129883,F-box-like domain superfamily,interpro,43624,Homedomain-like superfamily,0.77734375,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9209980749296609,0.018815161566238272,0.002658396101019052,,7.077636609166629,0.0,11.0,0.0,1.0,ABC ATPase phosphate switch,True,assigned_and_evaluated +12931,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic DHp hinge patch,False,no_term_above_threshold +12932,81739,17.933025,0.97509766,"DNA helicase RuvA subunit, C-terminal domain",gene3d,81739,"DNA helicase RuvA subunit, C-terminal domain",0.97509766,27,gene3d,1.10.8.10,gene3d:gene3d:1.10.8.10,6.0,2257.0,0.9995557529986673,0.7345238095238095,0.002658396101019052,1.0,276.303373015873,2.0,17.0,53.54378087112707,0.0011277160870075077,"Global small-protein, localized helical/disordered segments",True,assigned_and_evaluated +12933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic helical scaffolds,False,no_term_above_threshold +12934,82029,29.748035,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Membrane interface helix caps,True,assigned_too_few_test_positives +12935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA methyltransferase RNA-binding surface,False,no_term_above_threshold +12936,83267,16.077114,0.8925781,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.8925781,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,14.0,0.0,1.0,PUA-like C-terminal accessory domain,True,assigned_too_few_test_positives +12937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix caps and juxtamembrane loops,False,no_term_above_threshold +12938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global non-catalytic activation,False,no_term_above_threshold +12939,31094,16.094929,0.9316406,phosphopantetheine binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6074219,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9439919893190922,0.2448724410363818,0.004430660168365086,,55.26770994191138,0.0,16.0,0.0,1.0,SF3 viral helicase signature,True,assigned_and_evaluated +12940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nudix substrate-binding loop,False,no_term_above_threshold +12941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil membrane-binding helices,False,no_term_above_threshold +12942,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme N-terminal tail/helix-start,False,no_term_above_threshold +12943,50869,17.593649,0.8803711,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.8803711,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,15.0,0.0,1.0,FAS1 extracellular interaction patches,True,assigned_too_few_test_positives +12944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cobalamin-Radical SAM interdomain linker,False,no_term_above_threshold +12945,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ambiguous/recoded residue detector,False,no_term_above_threshold +12946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LexA/CI autocleavage loop,False,no_term_above_threshold +12947,47529,31.711664,0.9560547,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9560547,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.933623382418563,0.5703048392402092,0.007089056269384138,0.875,80.44862638532202,8.0,18.0,34.36864101455541,6.27513604968484e-11,Extracellular acidic Ca2+-binding loops,True,assigned_and_evaluated +12948,85672,35.1103,0.6870117,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6772461,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6754590024513484,0.27083835820174623,0.01595037660611431,0.2777777777777778,16.980060401703923,11.0,14.0,31.439645254074787,1.8349615167813176e-15,P-loop mid-domain activation,True,assigned_and_evaluated +12949,85649,28.730272,0.9814453,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9741211,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9414970223035304,0.7485421826342789,0.0101905183872397,0.782608695652174,73.45476983502466,15.0,15.0,110.61410018552876,7.1622047874657735e-31,SAM-dependent methyltransferase signature,True,assigned_and_evaluated +12950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Buried hydrophobic domain cores,False,no_term_above_threshold +12951,-1,,,,,-1,,,0,,,,,,,,,,,,,,,XRN YAPFASD motif,False,no_term_above_threshold +12952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity transcriptional activation domains,False,no_term_above_threshold +12953,87491,16.033995,0.7001953,GTP-binding,keyword,58239,P-loop containing nucleoside triphosphate hydrolase,0.60253906,82,keywords,GTP-binding,keyword:keywords:GTP-binding,20.0,2257.0,0.746177916852928,0.42353239177009666,0.008861320336730172,0.5,47.79563041125541,14.0,15.0,138.4235489220564,1.7572621847930324e-29,Ras-like small GTPase domain,True,assigned_and_evaluated +12954,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic sparse helical/disorder signal,False,no_term_above_threshold +12955,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix C-cap motif,False,no_term_above_threshold +12956,87326,26.604471,0.6508789,Coiled coil,keyword,87326,Coiled coil,0.6508789,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6946546291305609,0.32043824189567893,0.03943287549844927,0.34831460674157305,8.12616979728705,16.0,18.0,11.20669157209652,7.469626005007722e-16,Extended coiled-coil tethers,True,assigned_and_evaluated +12957,38317,19.259178,0.8173828,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.71191406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.637015873015873,0.08951691738576983,0.0031014621178555605,0.14285714285714285,28.862811791383216,0.0,19.0,0.0,1.0,Alpha-solenoid helical repeat scaffolds,True,assigned_and_evaluated +12958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serpin fold hydrophobic core,False,no_term_above_threshold +12959,87857,18.491238,0.61035156,Nucleus,keyword,87857,Nucleus,0.61035156,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6224342731501965,0.14258536955004616,0.06247230837394772,0.03546099290780142,2.2823771565564126,14.0,17.0,4.989801530368244,9.237150287686151e-09,Alpha-helical cores and acidic tracts,True,assigned_and_evaluated +12960,37020,17.712309,0.80566406,"Glycosyl transferase, family 1",interpro,37020,"Glycosyl transferase, family 1",0.80566406,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,10.0,0.0,1.0,Heptad-repeat coiled-coils,True,assigned_too_few_test_positives +12961,45804,19.208313,0.9536133,Major facilitator superfamily,interpro,87276,Cell membrane,0.6040039,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,10.0,0.0,1.0,Pre-TM amphipathic coupling helix,True,assigned_too_few_test_positives +12962,36010,18.126755,0.93652344,Alpha/beta hydrolase fold-1,interpro,36010,Alpha/beta hydrolase fold-1,0.93652344,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,16.0,0.0,1.0,Acidic glycine-rich loop motifs,True,assigned_too_few_test_positives +12963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional boundary linker segments,False,no_term_above_threshold +12964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FMN-oxidoreductase C-terminal beta-loop-helix,False,no_term_above_threshold +12965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix boundary/capping residues,False,no_term_above_threshold +12966,81685,19.699448,0.9355469,Transferase(Phosphotransferase) domain 1,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.9355469,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9560504825538232,0.8196549815522816,0.005316792202038104,0.9166666666666666,154.16344111362494,18.0,18.0,85.66235632183908,6.688146947710768e-35,APE-proximal activation loop motif,True,assigned_and_evaluated +12967,63831,29.01819,0.9501953,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9501953,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9613505108840515,0.036450919591226844,0.002658396101019052,,13.711620919566498,0.0,12.0,0.0,1.0,Kinase C-lobe αI helix,True,assigned_and_evaluated +12968,37894,24.109303,0.9975586,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.8339844,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,Ser/Thr-rich glycosyltransferase donor loop,True,assigned_too_few_test_positives +12969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-exporter TM and cytosolic segments,False,no_term_above_threshold +12970,37341,23.607916,0.9970703,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9926758,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,15.0,16.0,136.32850609756096,1.8495135190294293e-31,β-propeller blade β-strand site,True,assigned_and_evaluated +12971,85682,18.087463,0.87109375,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.87109375,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9641397849462366,0.2831996069227258,0.011076650420912717,0.36,25.567260512983683,3.0,12.0,25.566466552315607,0.00034635167648503515,Alpha-helical active-site scaffolds,True,assigned_and_evaluated +12972,36104,18.408165,0.8544922,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8544922,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,N-terminal recognition interface,True,assigned_too_few_test_positives +12973,36914,15.662578,0.75,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.75,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,17.0,0.0,1.0,Disordered cytosolic C-terminal tails,True,assigned_too_few_test_positives +12974,88164,15.768105,0.71875,Transposition,keyword,88164,Transposition,0.71875,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.4846802841918295,0.002215330084182543,0.002215330084182543,,1.0,1.0,15.0,48.47235772357723,0.03441021970110033,DNA binding interface regions,True,assigned_and_evaluated +12975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fold-stabilizing hydrophobic cores,False,no_term_above_threshold +12976,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cys-poor surface interaction patches,False,no_term_above_threshold +12977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich cofactor-binding segments,False,no_term_above_threshold +12978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding catalytic beta-strands,False,no_term_above_threshold +12979,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure capping loops,False,no_term_above_threshold +12980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal assembly beta-strands,False,no_term_above_threshold +12981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Whole-protein cystatin/stefin activation,False,no_term_above_threshold +12982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-chain assembly interface module,False,no_term_above_threshold +12983,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich mixed-charge IDRs,False,no_term_above_threshold +12984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining transmembrane helices,False,no_term_above_threshold +12985,59229,28.794895,0.78222656,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.78222656,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7993266124323694,0.46200644978906047,0.0101905183872397,0.5217391304347826,45.336893790169974,0.0,8.0,0.0,1.0,Conserved C-terminal domain cores,True,assigned_and_evaluated +12986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop interfaces,False,no_term_above_threshold +12987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass enzyme TM helices,False,no_term_above_threshold +12988,35372,16.382341,0.99560547,ABC-type transporter activity,go_mf,81858,Rhodopsin 7-helix transmembrane proteins,0.85498047,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,14.0,18.0,545.5516339869281,8.466064144375618e-37,Membrane helix-loop-helix junctions,True,assigned_too_few_test_positives +12989,36354,18.026688,1.0,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,1.0,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,19.0,20.0,203.74082733812946,7.26757959387553e-43,RRM RNP beta-strand RNA-binding,True,assigned_too_few_test_positives +12990,28962,17.584455,0.6855469,oxygen carrier activity,go_mf,28962,oxygen carrier activity,0.6855469,51,go,GO:0005344,go_mf:go:GO:0005344,,,,,,,,10.0,20.0,359.16265060240966,8.319634913346799e-24,Allosteric relay helices,True,assigned_too_few_test_positives +12991,87108,21.704382,0.7373047,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.7246094,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.7148329379201266,0.056346982745246965,0.003987594151528578,,14.130571117335823,0.0,16.0,0.0,1.0,Repeat-boundary cap residues,True,assigned_and_evaluated +12992,39971,15.62165,0.7910156,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,39971,"Calcineurin-like phosphoesterase domain, ApaH type",0.7910156,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,13.0,0.0,1.0,C-terminal domain end-cap motif,True,assigned_too_few_test_positives +12993,88263,42.79505,0.953125,Zinc-finger,keyword,29166,zinc ion binding,0.9189453,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9757603008502289,0.2302739718165141,0.014621178555604785,,15.749344072420374,7.0,18.0,10.133716977466976,5.051030239488238e-06,Cys-metal motif flanking residues,True,assigned_and_evaluated +12994,85664,20.747017,0.9790039,Glycogen Phosphorylase B;,gene3d,85656,alpha/beta hydrolase,0.80810547,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Trp-centered glycosyltransferase lid helix,True,assigned_too_few_test_positives +12995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic N-terminal soluble domains,False,no_term_above_threshold +12996,64168,17.25818,0.7324219,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.7324219,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.5929840142095915,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,12.0,12.0,334.9494382022472,1.3381480946638197e-30,Cytosolic catalytic headpieces and linkers,True,assigned_and_evaluated +12997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta-strand motifs,False,no_term_above_threshold +12998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topogenic helices and flanks,False,no_term_above_threshold +12999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core residues,False,no_term_above_threshold +13000,85682,19.01375,0.87890625,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.87890625,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9643369175627241,0.4550076775573986,0.011076650420912717,0.4,41.07809312988194,3.0,16.0,19.174849914236706,0.0008427773781769426,Helical patches near active sites,True,assigned_and_evaluated +13001,36449,15.654869,0.82470703,EamA domain,interpro,36449,EamA domain,0.82470703,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,18.0,0.0,1.0,Hydrophobic transmembrane alpha helices,True,assigned_too_few_test_positives +13002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar β-hairpin loop motif,False,no_term_above_threshold +13003,85762,26.329416,0.8105469,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.79345703,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,14.0,14.0,205.58965517241379,1.3323113268805393e-32,Flavoenzyme C-terminal helical cap,True,assigned_too_few_test_positives +13004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory mid-domain communication patch,False,no_term_above_threshold +13005,36104,29.03048,0.9790039,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9790039,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,C-terminal loop-strand-helix region,True,assigned_too_few_test_positives +13006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP-site helix-start recognition,False,no_term_above_threshold +13007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MELT-like Ser/Thr phosphosites,False,no_term_above_threshold +13008,38654,18.198357,0.94384766,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9350586,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,18.0,0.0,1.0,Noncatalytic chromatin regulator tails,True,assigned_too_few_test_positives +13009,29104,16.5038,0.7026367,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.69091797,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,0.0,17.0,0.0,1.0,TM1-TM2 boundary motif,True,assigned_too_few_test_positives +13010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP pyrophosphate-binding loop,False,no_term_above_threshold +13011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site flanking helices,False,no_term_above_threshold +13012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ion antiporter/exchanger TM bundle,False,no_term_above_threshold +13013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sec signal peptide cleavage site,False,no_term_above_threshold +13014,72011,20.083805,0.96435547,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.9394531,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,13.0,0.0,1.0,Short aliphatic beta-strand motif,True,assigned_too_few_test_positives +13015,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured DNA/RNA-binding/dimerization core,False,no_term_above_threshold +13016,87857,16.365868,0.6220703,Nucleus,keyword,87857,Nucleus,0.6220703,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6477513440319618,0.12410957377569903,0.06247230837394772,0.0070921985815602835,1.9866333901542745,9.0,20.0,2.7265701219512195,0.00458261389793322,Acidic low-complexity IDRs,True,assigned_and_evaluated +13017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH Rossmann catalytic core,False,no_term_above_threshold +13018,38878,17.602474,0.90722656,Immunoglobulin subtype,interpro,47529,Immunoglobulin-like fold,0.7973633,41,ip,IPR003599,interpro:ip:IPR003599,,,,,,,,0.0,15.0,0.0,1.0,Extracytoplasmic copper protein domains,True,assigned_too_few_test_positives +13019,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic interdomain linkers,False,no_term_above_threshold +13020,50806,21.104061,0.7558594,"Homeobox, conserved site",interpro,87566,Homeobox,0.6953125,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,14.0,0.0,1.0,Pilin-like N-terminal amphipathic helix,True,assigned_too_few_test_positives +13021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic THF/nucleic-acid-binding surfaces,False,no_term_above_threshold +13022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BED-domain central-region activation,False,no_term_above_threshold +13023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Restriction endonuclease N-terminal activation,False,no_term_above_threshold +13024,83032,17.038866,0.93115234,SH3 Domains,gene3d,83032,SH3 Domains,0.93115234,34,gene3d,2.30.30.40,gene3d:gene3d:2.30.30.40,6.0,2257.0,1.0,1.0,0.002658396101019052,1.0,376.16666666666663,10.0,18.0,163.16639299397923,1.8804309629614103e-20,SH3-like beta-loop motif,True,assigned_and_evaluated +13025,49116,25.685774,0.92041016,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.92041016,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,20.0,20.0,87.03795620437957,8.990576307619231e-39,HEAT/TOG/ARM solenoids with IDRs,True,assigned_and_evaluated +13026,25169,17.099215,0.75634766,pilus,go_cc,25169,pilus,0.75634766,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.897202486678508,0.31416855621291495,0.002215330084182543,0.6,141.81568627450983,0.0,16.0,0.0,1.0,Amphipathic helical assembly interfaces,True,assigned_and_evaluated +13027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal nucleotide-binding lid,False,no_term_above_threshold +13028,47529,19.88244,0.6923828,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.6923828,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7081938866577421,0.10833095673108198,0.007089056269384138,0.0625,15.281435583878253,4.0,17.0,18.195162890058747,0.00010602306835956829,Conserved adhesin β-strand motif,True,assigned_and_evaluated +13029,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil scaffold rods,False,no_term_above_threshold +13030,8138,19.230412,0.7548828,translation,go_bp,88022,Ribosomal protein,0.6850586,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.9163566522849345,0.11971525661275156,0.018165706690296855,,6.590178882316592,,,,,Switch-proximal gly/charged linkers,True,assigned_and_evaluated +13031,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved helix-adjacent pivots,False,no_term_above_threshold +13032,59224,17.034954,0.88134766,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.86376953,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9387619047619047,0.03145405122167815,0.0031014621178555605,,10.141684801046798,0.0,18.0,0.0,1.0,Hydrophobic β-loop nucleotide-pocket scaffolds,True,assigned_and_evaluated +13033,84152,24.94006,0.9848633,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9848633,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,Active-site gating loop,True,assigned_too_few_test_positives +13034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal leaders/tails,False,no_term_above_threshold +13035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic regulatory alpha helices,False,no_term_above_threshold +13036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent catalytic scaffolds,False,no_term_above_threshold +13037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-core interaction patches,False,no_term_above_threshold +13038,64507,34.524067,0.9946289,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9946289,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997528667457494,0.9436868686868689,0.003987594151528578,1.0,236.65569584736258,19.0,19.0,165.15512465373962,5.007107605336941e-42,Ankyrin repeat boundary signal,True,assigned_and_evaluated +13039,31094,17.063635,0.97802734,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.82910156,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9999554962171785,0.9909090909090909,0.004430660168365086,1.0,223.64818181818183,0.0,15.0,0.0,1.0,M3/S41 conserved helical motif,True,assigned_and_evaluated +13040,87586,17.656439,0.71484375,Host membrane,keyword,88161,Transmembrane helix,0.63671875,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7964511809106405,0.13609535914699492,0.01639344262295082,,8.301816907966689,0.0,19.0,0.0,1.0,Disordered noncytosolic juxtamembrane tails,True,assigned_and_evaluated +13041,43643,23.284004,1.0,Phosphopantetheine binding ACP domain,interpro,87913,Phosphopantetheine,1.0,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,1.0,0.9999999999999998,0.0057598582188746125,1.0,173.61538461538458,14.0,14.0,527.6194690265487,2.336963896583125e-38,PPant carrier-ANL interface,True,assigned_and_evaluated +13042,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-capping sites,False,no_term_above_threshold +13043,82029,24.313948,1.0,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6279297,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,19.0,168.2810891582268,1.3975966628625714e-36,MFS pore-gating TM helices,True,assigned_too_few_test_positives +13044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC exporter transmembrane helices,False,no_term_above_threshold +13045,58239,16.00528,0.7216797,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7216797,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8035915651781687,0.09396180974455177,0.017722640673460344,0.025,5.3017951148363345,17.0,17.0,35.851473241130485,1.1097904818074523e-26,Disordered low-complexity tails/linkers,True,assigned_and_evaluated +13046,82029,22.90521,0.9995117,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.63183594,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Pore-lining MFS helix hotspots,True,assigned_too_few_test_positives +13047,87586,16.635015,0.7548828,Host membrane,keyword,87760,Membrane,0.7104492,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.8340029218407596,0.2609058285270914,0.01639344262295082,0.24324324324324326,15.915255540152573,8.0,17.0,30.397552737237906,1.4517437403441367e-10,Membrane-docking amphipathic helices,True,assigned_and_evaluated +13048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GHKL ATPase lid region,False,no_term_above_threshold +13049,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich scaffold IDRs,False,no_term_above_threshold +13050,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC transporter TM hairpins,False,no_term_above_threshold +13051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered TF regulatory flanks,False,no_term_above_threshold +13052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha junction pocket hinges,False,no_term_above_threshold +13053,38317,17.45161,0.99365234,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9770508,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.903015873015873,0.6128490810544306,0.0031014621178555605,0.7142857142857143,197.60005370569283,2.0,17.0,45.25313092979127,0.0015672356275132431,Soluble non-membrane alpha-helices,True,assigned_and_evaluated +13054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal DPxGLR helix,False,no_term_above_threshold +13055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap boundary motif,False,no_term_above_threshold +13056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DOMON domain in cytochrome b561,False,no_term_above_threshold +13057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular acidic loop-helix junctions,False,no_term_above_threshold +13058,36409,15.875559,0.8178711,"Zinc finger, CCCH-type",interpro,61392,Leucine-rich repeat domain superfamily,0.8129883,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,15.0,0.0,1.0,Beta-solenoid repeat motifs,True,assigned_too_few_test_positives +13059,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted CAP/SCP and cysteine-rich modules,False,no_term_above_threshold +13060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic anchors and caps,False,no_term_above_threshold +13061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-protein activation Mo/W oxidoreductases,False,no_term_above_threshold +13062,85364,21.681864,0.8071289,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.8071289,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,0.0,19.0,0.0,1.0,Acidic disordered alpha tails,True,assigned_too_few_test_positives +13063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine-rich region detector,False,no_term_above_threshold +13064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site rim recognition loops,False,no_term_above_threshold +13065,63774,18.397497,0.87646484,RNA-binding domain superfamily,interpro,38317,Pentatricopeptide repeat,0.8378906,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,19.0,0.0,1.0,N-terminal pre-domain detector,True,assigned_too_few_test_positives +13066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FYR/UBM regulatory module,False,no_term_above_threshold +13067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cys-cluster metal-binding scaffolds,False,no_term_above_threshold +13068,85762,32.583492,0.89501953,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.890625,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,Hydrophobic redox substrate pocket,True,assigned_too_few_test_positives +13069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass TM interfacial motifs,False,no_term_above_threshold +13070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent nucleotidyl/phosphoryl-transfer cores,False,no_term_above_threshold +13071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic metal-binding SBPs,False,no_term_above_threshold +13072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-CA N-terminal motif hotspot,False,no_term_above_threshold +13073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane and kinase helices,False,no_term_above_threshold +13074,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent C-terminal helix,False,no_term_above_threshold +13075,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta1 anchoring strand,False,no_term_above_threshold +13076,47529,28.709177,0.89404297,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.89404297,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8962935073627846,0.3618648358735092,0.007089056269384138,0.1875,51.04555841040689,12.0,20.0,46.39766536964981,5.710117127717098e-18,Solvent-exposed strand-coil linkers,True,assigned_and_evaluated +13077,32577,16.421614,0.7583008,protein heterodimerization activity,go_mf,88147,Toxin-antitoxin system,0.703125,39,go,GO:0046982,go_mf:go:GO:0046982,,,,,,,,0.0,20.0,0.0,1.0,DNA-binding recognition helix,True,assigned_too_few_test_positives +13078,25014,17.142593,0.79248047,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.70166016,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.6497171145685997,0.06975173774362674,0.015507310589277802,0.02857142857142857,4.497990631067587,6.0,14.0,15.792247925128024,1.8954786013375023e-06,Juxtamembrane interface segments,True,assigned_and_evaluated +13079,85672,17.835112,0.7470703,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73583984,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8280429236079846,0.1123488751704754,0.01595037660611431,,7.043650312771194,3.0,15.0,8.002818791946309,0.009727562196002777,uL10/P0 N-helix Trp motif,True,assigned_and_evaluated +13080,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-acidic disordered tails,False,no_term_above_threshold +13081,87697,17.96688,0.8383789,Knottin,keyword,87697,Knottin,0.8383789,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7827275669926708,0.03652928787917278,0.017279574656623838,,2.11401545495623,0.0,16.0,0.0,1.0,Active-site flanking motifs,True,assigned_and_evaluated +13082,87239,15.849304,0.7446289,CF(1),keyword,84753,3.30.420.40,0.73535156,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9666182387125614,0.3029033444252356,0.008861320336730172,,34.182642418387836,0.0,15.0,0.0,1.0,Active-site cleft loop activation,True,assigned_and_evaluated +13083,29104,16.578611,0.8198242,NADH dehydrogenase (ubiquinone) activity,go_mf,88161,Transmembrane helix,0.6640625,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,2.0,15.0,57.19040767386091,0.0009847007215844743,C-terminal TM helix exits,True,assigned_too_few_test_positives +13084,32577,19.48467,0.9091797,protein heterodimerization activity,go_mf,32577,protein heterodimerization activity,0.9091797,39,go,GO:0046982,go_mf:go:GO:0046982,,,,,,,,7.0,7.0,146.8497536945813,1.5230368201844084e-15,Histone-fold and Lys/Arg-rich segments,True,assigned_too_few_test_positives +13085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zinc-finger-adjacent disordered segments,False,no_term_above_threshold +13086,36010,16.947336,0.8989258,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.8378906,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,8.0,10.0,407.6649572649573,2.0298702543558904e-20,ABH cap/lid activation,True,assigned_too_few_test_positives +13087,87409,17.165823,0.8520508,Dioxygenase,keyword,87409,Dioxygenase,0.8520508,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,11.0,20.0,153.95093896713615,4.181389753637021e-22,JmjC/2OG DSBH active-site lid,True,assigned_too_few_test_positives +13088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure cap residues,False,no_term_above_threshold +13089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered SLiMs and processing motifs,False,no_term_above_threshold +13090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal cofactor phosphate activation,False,no_term_above_threshold +13091,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase III catalytic core,False,no_term_above_threshold +13092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical hydrophobic-aromatic His-adjacent motifs,False,no_term_above_threshold +13093,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease-like catalytic cleft,False,no_term_above_threshold +13094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-hairpin turn residues,False,no_term_above_threshold +13095,85762,25.937767,0.79589844,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.79589844,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,19.0,19.0,205.58965517241379,1.005974624312525e-43,Flavoenzyme C-terminal catalytic region,True,assigned_too_few_test_positives +13096,82029,28.522108,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS pore-lining TM helices,True,assigned_too_few_test_positives +13097,36668,18.130625,0.9663086,AMP-dependent synthetase/ligase domain,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7871094,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,0.0,10.0,0.0,1.0,Rossmann fold scaffold helix,True,assigned_too_few_test_positives +13098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal Rossmann cofactor loop,False,no_term_above_threshold +13099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix–coil domain-edge segments,False,no_term_above_threshold +13100,88009,16.470512,0.61572266,Repeat,keyword,88009,Repeat,0.61572266,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6705161222658571,0.16786057404042368,0.07266282676118742,0.018292682926829267,2.3101299732270504,12.0,20.0,5.319345724907063,4.309452283718713e-07,Mucin-like and polyampholyte IDRs,True,assigned_and_evaluated +13101,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TM1–ECL1–TM2 hairpin,False,no_term_above_threshold +13102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Retrotransposon ORF2 C-terminal RNA-binding,False,no_term_above_threshold +13103,30332,16.487268,0.71972656,hydrolase activity,go_mf,87601,Hydrolase,0.64990234,296,go,GO:0016787,go_mf:go:GO:0016787,21.0,2257.0,0.7227830309225657,0.09247802976096062,0.00930438635356668,,9.939186341451816,0.0,12.0,0.0,1.0,Cleft-lining loop/turn junctions,True,assigned_and_evaluated +13104,37341,26.78024,0.99560547,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99560547,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9993356585284836,0.9230109398255897,0.011962782454585734,1.0,77.15687745134652,20.0,20.0,145.4170731707317,4.960484987757626e-43,Beta-propeller inter-strand loops,True,assigned_and_evaluated +13105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure capping loops,False,no_term_above_threshold +13106,25167,18.749928,0.6582031,cell outer membrane,go_cc,25167,cell outer membrane,0.6582031,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.8725129918337047,0.6801753518966634,0.005316792202038104,0.6666666666666666,127.92964743589744,8.0,17.0,64.20352671961233,4.009164850049992e-13,Outer membrane β-barrels and pore-formers,True,assigned_and_evaluated +13107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural insert scaffolds,False,no_term_above_threshold +13108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed nontransmembrane regulatory regions,False,no_term_above_threshold +13109,64155,17.076506,0.9667969,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.95947266,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,0.0,10.0,0.0,1.0,Toprim DxD metal-binding loop,True,assigned_too_few_test_positives +13110,45290,37.990803,0.9736328,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9736328,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9993829699712052,0.9553349875930521,0.0057598582188746125,0.9230769230769231,165.86085130750143,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Kinase N-lobe loop-strand motif,True,assigned_and_evaluated +13111,45551,18.357927,0.7963867,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7963867,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,2.0,16.0,42.58642857142857,0.001759289249810509,Channel cytosolic regulatory loops,True,assigned_too_few_test_positives +13112,64475,16.998074,0.92529297,ACP-like superfamily,interpro,59211,Nucleotide-diphospho-sugar transferases,0.8520508,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9870423693953106,0.21147352145406761,0.0057598582188746125,,36.71505676321774,0.0,19.0,0.0,1.0,GT active-site helical motif,True,assigned_and_evaluated +13113,42054,17.833048,0.99853516,Radical SAM,interpro,42054,Radical SAM,0.99853516,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,14.0,677.5113636363636,6.4988362365136876e-40,C-terminal Radical SAM core scaffold,True,assigned_too_few_test_positives +13114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface helix-start motif,False,no_term_above_threshold +13115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered flanking linkers and propeptides,False,no_term_above_threshold +13116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane targeting helical segments,False,no_term_above_threshold +13117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sirtuin NAD-binding core signature,False,no_term_above_threshold +13118,49116,19.541058,0.92089844,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.92089844,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9947602131438722,0.31507936507936507,0.002215330084182543,0.4,142.2268253968254,17.0,20.0,73.98226277372262,3.6634970709041876e-30,Alpha-solenoid and coiled-coil scaffolds,True,assigned_and_evaluated +13119,45714,16.757423,0.7011719,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,86137,Helix-loop-helix DNA-binding domain,0.6958008,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,9.0,0.0,1.0,Chemotaxis receptor coiled-coil heptads,True,assigned_too_few_test_positives +13120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Q-rich TAD-like IDRs,False,no_term_above_threshold +13121,52236,22.595196,0.9980469,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9946289,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,16.0,223.29962546816478,1.0796101345399494e-37,TPR A-B loop/turn,True,assigned_too_few_test_positives +13122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged polar low-hydrophobicity segments,False,no_term_above_threshold +13123,43583,16.735378,0.9404297,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9404297,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,14.0,14.0,416.9300699300699,6.605101239071875e-37,Protease post-catalytic beta-strand,True,assigned_and_evaluated +13124,49236,25.089565,0.90722656,C-type lectin fold,interpro,49236,C-type lectin fold,0.90722656,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.8980905861456484,0.5565036720774426,0.002215330084182543,0.6,251.2057575757576,12.0,14.0,464.57922077922075,3.0865827472057476e-31,C-terminal capping/recognition segment,True,assigned_and_evaluated +13125,38317,23.985434,0.9941406,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9941406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9991746031746032,0.6691403834260976,0.0031014621178555605,1.0,215.74997791324319,0.0,15.0,0.0,1.0,Disordered termini and juxtamembranes,True,assigned_and_evaluated +13126,47529,28.569134,0.9814453,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9814453,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9969879518072289,0.6572550917220035,0.007089056269384138,0.8125,92.71404637603511,7.0,19.0,28.489794525223566,5.283737104858649e-09,Trp-centered β-strand junction motif,True,assigned_and_evaluated +13127,45288,19.929443,0.9838867,CheY-like superfamily,interpro,85664,Glycogen Phosphorylase B;,0.8496094,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,14.0,14.0,462.17829457364337,1.5319912053906924e-37,REC alpha5 output helix,True,assigned_too_few_test_positives +13128,46932,29.412659,0.98046875,Zinc finger C2H2-type,interpro,88263,Zinc-finger,0.7524414,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.9999554962171784,0.9909090909090909,0.004430660168365086,1.0,223.64818181818183,17.0,17.0,108.20508166969147,1.0262878880954455e-34,C2H2-adjacent regulatory IDR,True,assigned_and_evaluated +13129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VWA alpha7 gating helix,False,no_term_above_threshold +13130,63951,24.014956,0.8730469,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.7597656,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9384391063661526,0.4424137680621654,0.003987594151528578,0.6666666666666666,110.94754161292305,0.0,14.0,0.0,1.0,Extracytoplasmic beta-sandwich strand-turns,True,assigned_and_evaluated +13131,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sirtuin deacetylase catalytic core,False,no_term_above_threshold +13132,50806,17.614136,0.9921875,"Homeobox, conserved site",interpro,87384,DNA-binding,0.7026367,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,HTH recognition-helix DNA contacts,True,assigned_too_few_test_positives +13133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha-helices,False,no_term_above_threshold +13134,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+ linker and active-site loops,False,no_term_above_threshold +13135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal peptides and anchors,False,no_term_above_threshold +13136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Megasubunit catalytic core scaffolds,False,no_term_above_threshold +13137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil helices and linkers,False,no_term_above_threshold +13138,38890,23.840508,0.9995117,HNH nuclease,interpro,38890,HNH nuclease,0.9995117,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,7.0,19.0,477.51372997711667,1.2428325320954005e-17,Histidine-centered catalytic motifs,True,assigned_too_few_test_positives +13139,45714,17.904593,0.87646484,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.8701172,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,14.0,16.0,260.841875,7.647027135682118e-33,Disordered effector tails flanking DBDs,True,assigned_too_few_test_positives +13140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic cofactor binding loops,False,no_term_above_threshold +13141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNAP two-barrel catalytic core,False,no_term_above_threshold +13142,64148,22.077162,0.7441406,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7441406,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6176097079159023,0.1971213968879299,0.008418254319893664,0.15789473684210525,23.41594698821357,18.0,18.0,88.9865671641791,3.4269283202124753e-35,HTH linker and dimerization helices,True,assigned_and_evaluated +13143,36409,15.636867,0.9667969,"Zinc finger, CCCH-type",interpro,8200,proteolysis,0.67041016,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,15.0,0.0,1.0,GxSxG catalytic serine loop,True,assigned_too_few_test_positives +13144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VOC/glyoxalase metal-binding core,False,no_term_above_threshold +13145,64620,15.695948,0.98046875,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8413086,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,16.0,16.0,324.0271739130435,3.056549823728774e-40,CA-domain ATP-binding beta-strands,True,assigned_too_few_test_positives +13146,59224,16.747335,0.92871094,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.74609375,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9625396825396826,0.04443408171382558,0.0031014621178555605,,14.32681748972919,3.0,18.0,22.895929339477725,0.000516767009095765,Beta-strand boundary loops,True,assigned_and_evaluated +13147,52236,18.593563,0.9902344,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9814453,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,11.0,17.0,144.48799294998898,3.9262665954059355e-22,TPR/Sel1 repeat register residues,True,assigned_too_few_test_positives +13148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface low-complexity repeats,False,no_term_above_threshold +13149,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic-side transporter TM helices,False,no_term_above_threshold +13150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted/periplasmic soluble proteins,False,no_term_above_threshold +13151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity disordered linkers/tails,False,no_term_above_threshold +13152,49061,17.8669,0.8833008,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8833008,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9299974363904376,0.08039030496520537,0.012405848471422242,,6.48003279665959,0.0,13.0,0.0,1.0,Active-site pocket-lining turns,True,assigned_and_evaluated +13153,81858,18.771227,0.82910156,Rhodopsin 7-helix transmembrane proteins,gene3d,87276,Cell membrane,0.6020508,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,1.0,13.0,20.115047233468285,0.0801839395233223,Polytopic ion-coupled membrane transporters,True,assigned_too_few_test_positives +13154,64475,15.7193,0.79541016,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.78027344,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.8034930755518991,0.23223149554926442,0.0057598582188746125,0.23076923076923078,40.31896041959152,0.0,15.0,0.0,1.0,Noncatalytic α/β core scaffold,True,assigned_and_evaluated +13155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rhodanese/DSP precatalytic scaffold,False,no_term_above_threshold +13156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Whole-protein QueF and chaperone marker,False,no_term_above_threshold +13157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PHR aromatic-basic N-terminus,False,no_term_above_threshold +13158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad SUVH SRA/YDG activation,False,no_term_above_threshold +13159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-capped signal-anchor boundary,False,no_term_above_threshold +13160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad activation of low-complexity IDRs,False,no_term_above_threshold +13161,36886,27.651056,0.99560547,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.99560547,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9954979991107159,0.47073029826567564,0.003544528134692069,0.75,132.80478539820373,20.0,20.0,233.80784313725488,6.513624004794376e-47,C-terminal TF effector domains,True,assigned_and_evaluated +13162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich glycan-recognition surfaces,False,no_term_above_threshold +13163,63951,17.83262,0.96972656,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.94970703,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9749901146698299,0.10884825636414641,0.003987594151528578,,27.296723845986495,0.0,20.0,0.0,1.0,Outer-membrane β-barrel loops,True,assigned_and_evaluated +13164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic C-terminal tails,False,no_term_above_threshold +13165,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site–proximal core segments,False,no_term_above_threshold +13166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polytopic membrane helix signature,False,no_term_above_threshold +13167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure junction patches,False,no_term_above_threshold +13168,88161,22.347795,0.6171875,Transmembrane helix,keyword,88161,Transmembrane helix,0.6171875,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7261840527577937,0.5262010473020485,0.1847585290208241,0.4580335731414868,2.8480473951096488,11.0,12.0,4.975201031709908,1.6254408560583877e-07,Conserved transmembrane flanking residues,True,assigned_and_evaluated +13169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity regulatory patches,False,no_term_above_threshold +13170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylated extracellular flexible regions,False,no_term_above_threshold +13171,82029,30.467495,0.9951172,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,18.0,188.0788643533123,6.824310871704072e-41,Secondary-active MFS TM12 hotspot,True,assigned_too_few_test_positives +13172,88058,29.333956,0.6201172,Signal,keyword,88058,Signal,0.6201172,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6047038385253701,0.1680682914840782,0.09127159946832078,0.04854368932038835,1.8414084168910898,4.0,14.0,2.0585584807941304,0.18987005539273782,Periplasmic beta-strand motifs,True,assigned_and_evaluated +13173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal exported N-terminus,False,no_term_above_threshold +13174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid linker IDRs,False,no_term_above_threshold +13175,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity secretion leaders/linkers,False,no_term_above_threshold +13176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal disordered microproteins,False,no_term_above_threshold +13177,45290,17.367958,0.890625,Protein kinase-like domain superfamily,interpro,87855,Nucleotide-binding,0.71972656,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9086966954614013,0.05870817285299958,0.0057598582188746125,,10.192642009940004,0.0,15.0,0.0,1.0,IscS/SufS motif detector,True,assigned_and_evaluated +13178,69093,17.203596,0.99658203,"ANL, N-terminal domain",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9321289,40,ip,IPR042099,interpro:ip:IPR042099,,,,,,,,15.0,16.0,490.3042763157895,8.397986729434604e-40,ANL adenylation domain hydrophobic scaffold,True,assigned_too_few_test_positives +13179,25167,16.130917,0.74121094,cell outer membrane,go_cc,25167,cell outer membrane,0.74121094,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9520972531551596,0.5551811147064981,0.005316792202038104,0.75,104.42031465771385,19.0,19.0,136.43249427917618,1.6911837426464007e-40,Outer membrane beta-barrels,True,assigned_and_evaluated +13180,87601,17.128885,0.6459961,Hydrolase,keyword,87601,Hydrolase,0.6459961,1174,keywords,Hydrolase,keyword:keywords:Hydrolase,120.0,2257.0,0.6786363281859304,0.08639652881500057,0.05316792202038104,,1.624974712795469,7.0,15.0,5.219120865378603,0.000278020667773252,Hydrolase core Tyr-helix motif,True,assigned_and_evaluated +13181,47717,16.23129,0.9711914,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6669922,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,12.0,0.0,1.0,Motor-domain N-terminal entry segment,True,assigned_too_few_test_positives +13182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SUN lumenal coiled coil stalks,False,no_term_above_threshold +13183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Y-recombinase/TopIB catalytic core,False,no_term_above_threshold +13184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TOPRIM C-terminal helix detector,False,no_term_above_threshold +13185,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered targeting segments,False,no_term_above_threshold +13186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CapZ alpha C-terminal motif,False,no_term_above_threshold +13187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal mixed-residue activation peaks,False,no_term_above_threshold +13188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TULIP lipid-binding tunnels,False,no_term_above_threshold +13189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAL-domain c-di-GMP phosphodiesterases,False,no_term_above_threshold +13190,64016,36.896053,0.8984375,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.89697266,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8513650793650795,0.2931665224507094,0.0031014621178555605,0.5714285714285714,94.52526302446444,14.0,15.0,206.8634448574969,6.533515411716639e-32,Pre-active-site beta-alpha patch,True,assigned_and_evaluated +13191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Autoprocessing and gating loops,False,no_term_above_threshold +13192,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic loop–TM signature,False,no_term_above_threshold +13193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming effector core,False,no_term_above_threshold +13194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HAT/TPR helical repeat scaffolds,False,no_term_above_threshold +13195,38317,18.12249,0.67285156,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.67285156,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6990476190476191,0.019542826837908804,0.0031014621178555605,,6.301165739022881,0.0,16.0,0.0,1.0,N-terminal membrane-targeting signals,True,assigned_and_evaluated +13196,35372,19.928787,0.9711914,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9711914,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,7.0,18.0,272.77581699346405,6.951330121626393e-16,N-terminal Sec/SRP start-transfer signal,True,assigned_too_few_test_positives +13197,30107,15.994235,0.8144531,nickel cation binding,go_mf,30107,nickel cation binding,0.8144531,31,go,GO:0016151,go_mf:go:GO:0016151,20.0,2257.0,0.9744188645507376,0.9453114870694681,0.008861320336730172,0.95,106.67840131578949,4.0,16.0,149.0525,2.6742656205886703e-08,Metal/O2 redox and targeting,True,assigned_and_evaluated +13198,36010,17.535892,0.99072266,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9628906,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,6.0,19.0,160.92037786774628,2.920292889380285e-12,AB-hydrolase N-cap motif,True,assigned_too_few_test_positives +13199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long coiled-coil scaffolds,False,no_term_above_threshold +13200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered basic-flanked KPAP motifs,False,no_term_above_threshold +13201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Pro-rich PDZ-flanking IDRs,False,no_term_above_threshold +13202,87326,23.499208,0.6591797,Coiled coil,keyword,87326,Coiled coil,0.6591797,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7338794104233177,0.2800139216194107,0.03943287549844927,0.20224719101123595,7.101027203314718,14.0,20.0,8.825269613026009,2.0214631234677817e-11,Polyampholytic phospho-rich IDRs,True,assigned_and_evaluated +13203,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-spanning helices and loops,False,no_term_above_threshold +13204,83267,18.651566,0.9794922,DNA-binding pseudobarrel domain,gene3d,48767,DNA-binding pseudobarrel domain superfamily,0.9790039,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,12.0,0.0,1.0,SRA/YDG DNA methylation reader,True,assigned_too_few_test_positives +13205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,α/β fold β-sheet core,False,no_term_above_threshold +13206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BEN/HORMA helical interaction cores,False,no_term_above_threshold +13207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positive-inside cytosolic TM anchors,False,no_term_above_threshold +13208,25167,17.263182,0.73339844,cell outer membrane,go_cc,25167,cell outer membrane,0.73339844,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9516703786191537,0.6132564678927384,0.005316792202038104,0.75,115.34332066949253,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel strands,True,assigned_and_evaluated +13209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface charged interaction patches,False,no_term_above_threshold +13210,87409,19.404768,0.85791016,Dioxygenase,keyword,87409,Dioxygenase,0.85791016,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,11.0,15.0,205.26791862284819,3.707996503301616e-24,2OG oxygenase jelly-roll core,True,assigned_too_few_test_positives +13211,37468,19.54675,0.96972656,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.91748047,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,0.0,19.0,0.0,1.0,Cys/His metal-binding microdomains,True,assigned_too_few_test_positives +13212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Integrin FG-GAP beta-propellers,False,no_term_above_threshold +13213,47529,24.488962,0.88720703,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.88720703,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9523092369477912,0.2775878132963705,0.007089056269384138,0.0625,39.157230913119264,14.0,16.0,67.66326199740597,1.1390235956303516e-24,Beta-strand interaction patches,True,assigned_and_evaluated +13214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged DNA-binding loops,False,no_term_above_threshold +13215,82029,22.018633,0.99902344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6591797,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,Hydrophobic interfacial helical segments,True,assigned_too_few_test_positives +13216,85672,18.272892,0.7290039,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.7290039,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7555405473010155,0.052227693748746654,0.01595037660611431,,3.2743862441922555,1.0,18.0,2.223005219985086,0.5707478730186062,Active-site metal/phosphate microloops,True,assigned_and_evaluated +13217,85762,33.012066,0.953125,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9511719,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,14.0,14.0,205.58965517241379,1.3323113268805393e-32,FAD-proximal substrate-binding region,True,assigned_too_few_test_positives +13218,48883,18.574461,0.9736328,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9736328,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,0.0,19.0,0.0,1.0,ATP-grasp phosphate-binding loop,True,assigned_too_few_test_positives +13219,38317,27.855715,0.9995117,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9995117,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9968888888888888,0.6799374810653007,0.0031014621178555605,0.7142857142857143,219.23127068062624,0.0,18.0,0.0,1.0,Hydroxyl-lined solvent-exposed ligand patches,True,assigned_and_evaluated +13220,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine protease catalytic core,False,no_term_above_threshold +13221,36104,21.496168,0.9555664,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9555664,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Amidohydrolase catalytic domain signature,True,assigned_too_few_test_positives +13222,36115,18.947624,0.7841797,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7792969,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,15.0,0.0,1.0,Charged amphipathic recognition helices,True,assigned_too_few_test_positives +13223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane helix caps,False,no_term_above_threshold +13224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding catalytic cores,False,no_term_above_threshold +13225,63831,17.181656,0.87939453,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.87939453,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8271508958981193,0.00857537541609547,0.002658396101019052,,3.2257703856879125,0.0,15.0,0.0,1.0,Membrane hydrophobic helix signature,True,assigned_and_evaluated +13226,63831,17.248304,0.9379883,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9379883,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8516215015548645,0.009990402723825304,0.002658396101019052,,3.7580564912789516,0.0,17.0,0.0,1.0,N-terminal basic amphipathic helix,True,assigned_and_evaluated +13227,85649,16.259708,0.85058594,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8486328,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8772040792495426,0.28226410207301217,0.0101905183872397,0.34782608695652173,27.698699059947323,1.0,18.0,6.14522778808493,0.2397823808485301,Ala/Gln-rich loop motif,True,assigned_and_evaluated +13228,87239,16.019659,0.7841797,CF(1),keyword,87239,CF(1),0.7841797,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9853822083147072,0.22923436245915818,0.008861320336730172,,25.869097803516002,0.0,15.0,0.0,1.0,Early N-terminal compact domain,True,assigned_and_evaluated +13229,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/solenoid assembly scaffolds,False,no_term_above_threshold +13230,59224,20.601143,0.9716797,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.90234375,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.984,0.09373151841182531,0.0031014621178555605,,30.221719579355675,0.0,15.0,0.0,1.0,Parallel β-sheet hydrophobic core,True,assigned_and_evaluated +13231,47529,21.077589,0.88720703,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.88720703,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9112421909861668,0.11272020636997888,0.007089056269384138,,15.900594111065146,1.0,16.0,4.833090142671855,0.29742221945743563,C-terminal hydrophobic β-strand clusters,True,assigned_and_evaluated +13232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short extracellular surface loops,False,no_term_above_threshold +13233,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-contacting low-complexity segments,False,no_term_above_threshold +13234,49061,26.766989,0.9560547,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9560547,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8574793308979042,0.22232615387517607,0.012405848471422242,,17.921076046295443,3.0,16.0,18.53886815920398,0.0009274250120253182,β-propellers with N-terminal stalks,True,assigned_and_evaluated +13235,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic charge-rich coiled-coil scaffolds,False,no_term_above_threshold +13236,38317,20.665703,0.875,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.875,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8472380952380952,0.10377430484665785,0.0031014621178555605,,33.459800862700966,0.0,17.0,0.0,1.0,Amphipathic alpha-helical repeat cores,True,assigned_and_evaluated +13237,82029,33.289654,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.99121094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,19.0,178.17997675576953,1.0664105398646098e-39,MFS TM4/TM10 intracellular gate,True,assigned_too_few_test_positives +13238,82716,17.208687,0.7993164,Laminin,gene3d,82716,Laminin,0.7993164,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,0.0,17.0,0.0,1.0,Actinobacterial extracellular surface domains,True,assigned_too_few_test_positives +13239,25229,17.075628,0.9760742,cytochrome b6f complex,go_cc,29104,NADH dehydrogenase (ubiquinone) activity,0.85009766,25,go,GO:0009512,go_cc:go:GO:0009512,5.0,2257.0,0.9975133214920071,0.32820346320346316,0.002215330084182543,,148.15104329004328,0.0,10.0,0.0,1.0,Bioenergetic transmembrane helices,True,assigned_and_evaluated +13240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Positive-inside amphipathic helical cores,False,no_term_above_threshold +13241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SNW/SKI interaction core,False,no_term_above_threshold +13242,85672,38.593456,0.9472656,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.9345703,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9460453249287107,0.6843912545558657,0.01595037660611431,0.75,42.90752948701636,12.0,12.0,40.01409395973155,1.4584552891973136e-19,ATPase Walker B +1 flank,True,assigned_and_evaluated +13243,50763,19.65115,0.96777344,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.9526367,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,19.0,0.0,1.0,Tyrosine recombinase active-site helix,True,assigned_too_few_test_positives +13244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-wall/ECM remodeling proteins,False,no_term_above_threshold +13245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble extramembrane head domains,False,no_term_above_threshold +13246,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fic AMPylator catalytic core,False,no_term_above_threshold +13247,36876,16.20633,0.9555664,Cytochrome P450,interpro,36876,Cytochrome P450,0.9555664,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9949584816132858,0.3171637004970338,0.003987594151528578,,79.53760800242281,0.0,16.0,0.0,1.0,Glycine-rich alternating-access TM bundle,True,assigned_and_evaluated +13248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like RCK/KTN regulators,False,no_term_above_threshold +13249,63831,20.347185,0.97265625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.97265625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9173700577521102,0.01739807006501701,0.002658396101019052,,6.544574022790565,0.0,14.0,0.0,1.0,Helix-start N-cap motif,True,assigned_and_evaluated +13250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase transmitter module,False,no_term_above_threshold +13251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic-aromatic major-groove DNA clamp,False,no_term_above_threshold +13252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loops and linkers,False,no_term_above_threshold +13253,64148,17.841047,0.62597656,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.62597656,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5418018907859461,0.014086970946332465,0.008418254319893664,,1.6733838645195986,12.0,18.0,59.32437810945273,1.6458679506894985e-19,Broad replication and matrix peaks,True,assigned_and_evaluated +13254,85682,17.712915,0.8125,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8125,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9502329749103943,0.2329683352490653,0.011076650420912717,,21.032381306285615,8.0,18.0,45.451496093005524,6.95743162413177e-12,Nucleotide/cofactor-binding active sites,True,assigned_and_evaluated +13255,37640,21.038332,0.99609375,EF-hand domain,interpro,46081,EF-hand domain pair,0.9902344,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,14.0,19.0,220.76011637133033,6.091415411691019e-31,EF-hand Ca2+-binding loops,True,assigned_too_few_test_positives +13256,52941,19.337568,0.99902344,Major facilitator superfamily domain,interpro,63831,F-box-like domain superfamily,0.8769531,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,20.0,20.0,260.353711790393,9.072183617335922e-48,Transmembrane helix boundary residues,True,assigned_too_few_test_positives +13257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KH/OB ssRNA-binding domains,False,no_term_above_threshold +13258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil assembly scaffolds,False,no_term_above_threshold +13259,87326,35.636845,0.6899414,Coiled coil,keyword,87326,Coiled coil,0.6899414,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6630016791740951,0.286533143302647,0.03943287549844927,0.25842696629213485,7.266351735214318,18.0,19.0,11.943973912366028,6.647492796621427e-19,Charged coiled-coil rods,True,assigned_and_evaluated +13260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage tail fiber distal motifs,False,no_term_above_threshold +13261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAM-dependent DNA N6-adenine methyltransferase core,False,no_term_above_threshold +13262,37341,28.710184,0.9897461,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97998047,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9980568011958147,0.7226129648805593,0.011962782454585734,1.0,60.405091175386005,1.0,18.0,8.078726287262871,0.1879739444796349,WD/GH propeller blade termini,True,assigned_and_evaluated +13263,36091,21.062458,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,GNAT acetyl-CoA-binding loop,True,assigned_too_few_test_positives +13264,35372,21.896685,0.9355469,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.9355469,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,9.0,16.0,394.55073529411766,4.885894964019024e-22,Hydrophobic transmembrane helices,True,assigned_too_few_test_positives +13265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IQ calmodulin-binding regulatory helices,False,no_term_above_threshold +13266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane proteostasis cytosolic tails,False,no_term_above_threshold +13267,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal HUH/Tyr nickase,False,no_term_above_threshold +13268,49230,16.526028,0.9667969,Acyl-CoA N-acyltransferase,interpro,88153,Transferase,0.6699219,66,ip,IPR016181,interpro:ip:IPR016181,,,,,,,,0.0,14.0,0.0,1.0,Conserved TIM/Rossmann helices near cofactors,True,assigned_too_few_test_positives +13269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic docking helix,False,no_term_above_threshold +13270,36535,21.934198,0.93408203,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9057617,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9451490876724521,0.2930977367674825,0.004430660168365086,,66.15215918842081,6.0,17.0,31.690822111977322,4.1451873667301796e-08,Exposed acidic Ser/Thr regulatory segments,True,assigned_and_evaluated +13271,59224,16.120127,0.8310547,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.8310547,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9713015873015873,0.2457442285327883,0.0031014621178555605,0.2857142857142857,79.23496054264331,0.0,17.0,0.0,1.0,Surface ligand-binding loops,True,assigned_and_evaluated +13272,45288,23.586535,0.9838867,CheY-like superfamily,interpro,45288,CheY-like superfamily,0.9838867,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,17.0,17.0,462.17829457364337,3.827449248759242e-45,REC helix N-cap motif,True,assigned_too_few_test_positives +13273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic peptidoglycan and polyanion binders,False,no_term_above_threshold +13274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short alpha-helical interface elements,False,no_term_above_threshold +13275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible helix–loop regulatory patches,False,no_term_above_threshold +13276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Auxiliary calcium-binding metalloprotease domains,False,no_term_above_threshold +13277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix surface packing,False,no_term_above_threshold +13278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic domain-edge ligand patches,False,no_term_above_threshold +13279,87913,15.599062,0.9042969,Phosphopantetheine,keyword,64146,Winged helix-like DNA-binding domain superfamily,0.80126953,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.9456881727278518,0.12497052964793892,0.006202924235711121,,20.147034672528438,0.0,20.0,0.0,1.0,Domain boundary amphipathic interface helices,True,assigned_and_evaluated +13280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-sheet adhesion interfaces,False,no_term_above_threshold +13281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solute-binding cleft helix-loop,False,no_term_above_threshold +13282,46277,20.683224,0.9555664,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9555664,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.982352464988262,0.20460235860389026,0.004873726185201595,,41.98068394263458,7.0,14.0,94.03943217665615,8.278748795998594e-13,Conserved beta-strand core hydrophobics,True,assigned_and_evaluated +13283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix/strand boundary capping,False,no_term_above_threshold +13284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta-rich rim loops,False,no_term_above_threshold +13285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble extramembrane domains,False,no_term_above_threshold +13286,38317,16.065256,0.87646484,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.87646484,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6987301587301588,0.023494881072981907,0.0031014621178555605,,7.5754209402457375,0.0,17.0,0.0,1.0,Plant N-terminal S/T/P-rich IDRs,True,assigned_and_evaluated +13287,39971,21.104761,0.9614258,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.94140625,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,12.0,14.0,567.8190476190476,2.5676685584281437e-32,Metallohydrolase catalytic-core loop-helices,True,assigned_too_few_test_positives +13288,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic ligand-binding ectodomains,False,no_term_above_threshold +13289,52941,21.537445,0.99853516,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9902344,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,20.0,20.0,260.353711790393,9.072183617335922e-48,MFS transmembrane helix packing,True,assigned_too_few_test_positives +13290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid PPI scaffolds,False,no_term_above_threshold +13291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site gating loop,False,no_term_above_threshold +13292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix C-cap connector motif,False,no_term_above_threshold +13293,64058,16.93102,0.8613281,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7651367,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9617221833004268,0.1626162966697386,0.006202924235711121,,26.216070113114284,1.0,16.0,7.12488049713193,0.21028084137787656,Short alpha-helical microsegments,True,assigned_and_evaluated +13294,87274,16.633608,0.6713867,Cell inner membrane,keyword,88161,Transmembrane helix,0.64404297,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.518765318627451,0.037969987676932666,0.0358883473637572,,1.0580032368745311,12.0,18.0,25.99563985175496,2.9320846333444828e-15,Hydrophobic TM helix cores,True,assigned_and_evaluated +13295,85649,21.103191,0.64990234,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6479492,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7135183527305282,0.25261124141936264,0.0101905183872397,0.17391304347826086,24.788850951456585,0.0,11.0,0.0,1.0,Nucleotide-donor α/β catalytic cores,True,assigned_and_evaluated +13296,36091,24.783485,0.9995117,GNAT domain,interpro,85712,3.40.630.30,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,16.0,17.0,355.1511541325391,3.960299025280445e-40,GNAT CoA-binding beta-strand,True,assigned_too_few_test_positives +13297,36010,18.19343,0.9863281,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9760742,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,5.0,16.0,159.24412393162396,2.402509573891527e-10,Hydrolase cap/lid loop,True,assigned_too_few_test_positives +13298,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor transmembrane helix,False,no_term_above_threshold +13299,85364,19.398125,0.9946289,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9946289,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,Strand-loop pocket rim motifs,True,assigned_too_few_test_positives +13300,59224,30.97666,0.9746094,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9746094,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Hydrolase cap strand loop pivots,True,assigned_and_evaluated +13301,87326,41.07816,0.80078125,Coiled coil,keyword,87326,Coiled coil,0.80078125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.83506260624404,0.30670919391788454,0.03943287549844927,0.4943820224719101,7.7780073109288255,8.0,18.0,5.60334578604826,6.081376168324585e-05,Alpha-helical coiled-coil interfaces,True,assigned_and_evaluated +13302,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic juxtamembrane cytosolic tails,False,no_term_above_threshold +13303,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DEP-associated RhoGAP and adaptor regions,False,no_term_above_threshold +13304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Gly-rich beta-solenoid motif,False,no_term_above_threshold +13305,37894,26.325289,0.9326172,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9326172,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,14.0,0.0,1.0,Active-site histidine loop motif,True,assigned_too_few_test_positives +13306,45290,35.959595,0.9746094,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9746094,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9612642259701084,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,14.0,14.0,73.42487684729065,2.1479968934241087e-26,Kinase HRD catalytic loop,True,assigned_and_evaluated +13307,30856,19.465546,0.84277344,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.6333008,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7428063943161636,0.012607942669412515,0.002215330084182543,,5.69122532097281,1.0,15.0,8.931985018726591,0.17175825846904266,Small residue transmembrane helix detector,True,assigned_and_evaluated +13308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DAGKc C-terminal catalytic segment,False,no_term_above_threshold +13309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAC capping motif,False,no_term_above_threshold +13310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal disordered polar stretches,False,no_term_above_threshold +13311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil oligomers,False,no_term_above_threshold +13312,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-core polyanion-contact patch,False,no_term_above_threshold +13313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease transmembrane helix,False,no_term_above_threshold +13314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical extension,False,no_term_above_threshold +13315,72011,16.961023,0.9975586,"AMP-binding enzyme, C-terminal domain superfamily",interpro,87913,Phosphopantetheine,0.9458008,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,20.0,0.0,1.0,Terminal acidic disordered tails,True,assigned_too_few_test_positives +13316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining helices and loops,False,no_term_above_threshold +13317,31094,15.869852,0.9785156,phosphopantetheine binding,go_mf,64058,NAD(P)-binding domain superfamily,0.6611328,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9963729417000445,0.5420775477752222,0.004430660168365086,0.8,122.34690253286766,11.0,17.0,459.265406162465,9.09073102711806e-28,C-terminal accessory docking subdomains,True,assigned_and_evaluated +13318,84152,17.325201,0.7763672,Metal-dependent hydrolases,gene3d,59218,Metallo-dependent phosphatase-like,0.77246094,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,15.0,0.0,1.0,Mre11/SbcD capping/dimerization helix,True,assigned_too_few_test_positives +13319,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AGT-like DNA-binding helix,False,no_term_above_threshold +13320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal membrane-engagement modules,False,no_term_above_threshold +13321,59224,26.262419,0.7578125,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.7578125,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7798730158730158,0.12424199953473958,0.0031014621178555605,,40.05917042141532,13.0,15.0,119.05883256528418,4.4056922514550933e-26,Lipolytic serine-hydrolase lid surface,True,assigned_and_evaluated +13322,64475,16.492912,0.9433594,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.9165039,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9199917729329493,0.5681385377476171,0.0057598582188746125,0.8461538461538461,98.63759074587476,0.0,19.0,0.0,1.0,Surface-exposed binding patches,True,assigned_and_evaluated +13323,83267,16.132383,0.8339844,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.8339844,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,19.0,0.0,1.0,Interdomain regulatory linkers,True,assigned_too_few_test_positives +13324,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-biased structural signal,False,no_term_above_threshold +13325,45553,21.957403,0.9604492,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.9243164,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,2.0,19.0,72.13672111312765,0.0006327759446720944,Divalent-metal nuclease active site,True,assigned_too_few_test_positives +13326,39971,16.74362,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98535156,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,19.0,20.0,629.3327777777778,1.614506051624851e-51,Phosphoesterase active-site loops,True,assigned_too_few_test_positives +13327,82029,34.975246,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9819336,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Extracytoplasmic gate helix-loop,True,assigned_too_few_test_positives +13328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Integrase zinc finger linker helix,False,no_term_above_threshold +13329,86130,16.386175,0.9301758,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9267578,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9249206349206349,0.6762934061528909,0.0031014621178555605,0.8571428571428571,218.05631681243926,18.0,18.0,240.4072580645161,9.531793462767385e-43,Acidic disordered activation domains,True,assigned_and_evaluated +13330,64058,18.311972,0.71972656,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.71972656,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7986115534042417,0.07105235094376805,0.006202924235711121,0.07142857142857142,11.45465400572032,9.0,12.0,85.49856596558317,1.486687396935183e-16,Catalytic beta-loop-alpha pocket segment,True,assigned_and_evaluated +13331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor histidine kinase GAF-linker motif,False,no_term_above_threshold +13332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered C-terminal tails,False,no_term_above_threshold +13333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane interface loops and termini,False,no_term_above_threshold +13334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal IDR boundary,False,no_term_above_threshold +13335,52941,24.10345,0.9345703,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.8828125,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,9.0,15.0,156.2122270742358,1.9011525849012655e-18,12-helix MFS carrier fold,True,assigned_too_few_test_positives +13336,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA maintenance catalytic cores,False,no_term_above_threshold +13337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oligomerization scaffold interfaces,False,no_term_above_threshold +13338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal assembly tether,False,no_term_above_threshold +13339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix boundaries and disordered tails,False,no_term_above_threshold +13340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interacting β-edge hairpin,False,no_term_above_threshold +13341,28025,18.353483,0.87402344,GTPase activity,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6699219,32,go,GO:0003924,go_mf:go:GO:0003924,6.0,2257.0,0.9134828964904488,0.44568116125493173,0.002658396101019052,0.8333333333333334,167.6503968253968,7.0,14.0,135.50227272727273,6.48477757837682e-14,GTPase G4 guanine-recognition subdomain,True,assigned_and_evaluated +13342,46929,21.558804,0.9003906,"Zinc finger, RING/FYVE/PHD-type",interpro,88261,Zinc,0.72753906,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9818827708703375,0.12400525122329634,0.002215330084182543,,55.97597040219597,5.0,16.0,26.846631844380404,1.5928159707772952e-06,Zinc-binding modules and disorder,True,assigned_and_evaluated +13343,36091,23.713474,0.9814453,GNAT domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.94189453,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,Post-Walker A helix hydrophobics,True,assigned_too_few_test_positives +13344,85791,16.831713,0.7519531,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.7519531,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,14.0,0.0,1.0,GATase-enriched catalytic pocket segment,True,assigned_too_few_test_positives +13345,88009,15.838744,0.6074219,Repeat,keyword,88009,Repeat,0.6074219,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6233306725088273,0.14682272790023382,0.07266282676118742,0.018292682926829267,2.020603029700169,12.0,20.0,5.319345724907063,4.309452283718713e-07,Low-complexity glycine-rich repeats,True,assigned_and_evaluated +13346,64585,17.09743,0.7109375,"Zinc finger, CCCH-type superfamily",interpro,64585,"Zinc finger, CCCH-type superfamily",0.7109375,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,13.0,0.0,1.0,Repeat-rich acyl/carbohydrate scaffolds,True,assigned_too_few_test_positives +13347,45324,17.928267,0.86865234,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.86865234,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9962699822380107,0.25024114774114775,0.002215330084182543,,112.95885409035411,12.0,16.0,410.23623853211006,5.0951400600667235e-30,Beta-edge repeat motif,True,assigned_and_evaluated +13348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity IDRs,False,no_term_above_threshold +13349,64155,19.330694,0.9453125,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9277344,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,13.0,14.0,257.4993355481728,6.684006324971496e-31,Nucleic acid enzyme beta-strands,True,assigned_too_few_test_positives +13350,59224,25.080143,0.7133789,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.7133789,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7822857142857144,0.4527577694790809,0.0031014621178555605,0.42857142857142855,145.9820408163265,10.0,10.0,137.37557603686636,1.02382925547944e-21,Secreted hydrolase structural core,True,assigned_and_evaluated +13351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil/IDR interaction scaffolds,False,no_term_above_threshold +13352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-cap and helix start,False,no_term_above_threshold +13353,64148,19.265345,0.6538086,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6538086,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5991251587413574,0.12895720306719294,0.008418254319893664,0.10526315789473684,15.31875828013971,15.0,15.0,88.9865671641791,1.8111397886309825e-29,Terminal helix/tail interaction motif,True,assigned_and_evaluated +13354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase active sites,False,no_term_above_threshold +13355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic beta-strand motifs,False,no_term_above_threshold +13356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical patches outside active sites,False,no_term_above_threshold +13357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular coiled-coil stalks,False,no_term_above_threshold +13358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aliphatic-rich extracellular/scaffold domains,False,no_term_above_threshold +13359,50338,15.708977,0.9970703,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9692383,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,15.0,16.0,367.7282072368421,6.60725286365628e-38,Class A GPCR TM5–ICL3 signature,True,assigned_too_few_test_positives +13360,81739,15.939301,0.9785156,"DNA helicase RuvA subunit, C-terminal domain",gene3d,81739,"DNA helicase RuvA subunit, C-terminal domain",0.9785156,27,gene3d,1.10.8.10,gene3d:gene3d:1.10.8.10,6.0,2257.0,1.0,1.0,0.002658396101019052,1.0,376.16666666666663,7.0,16.0,199.1159351145038,5.519926348486015e-15,Amphipathic helical interaction motifs,True,assigned_and_evaluated +13361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM exit tail,False,no_term_above_threshold +13362,45551,25.629505,0.89746094,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.89746094,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,15.0,0.0,1.0,HPt phospho-histidine helix,True,assigned_too_few_test_positives +13363,87198,17.789156,0.77734375,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.77734375,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,16.0,17.0,684.3156384505021,1.128051036909839e-44,Flagellar and T3SS assembly subunits,True,assigned_too_few_test_positives +13364,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Elongated helical scaffolds,False,no_term_above_threshold +13365,87276,37.001595,0.6660156,Cell membrane,keyword,88161,Transmembrane helix,0.65625,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6720436300659774,0.3053726352254735,0.11120957022596367,0.3386454183266932,2.7459204689398153,2.0,18.0,0.9117197296388048,1.0,Helix-loop-helix TM junction,True,assigned_and_evaluated +13366,63951,23.241716,0.8598633,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.77441406,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8838473705021748,0.4516316827792237,0.003987594151528578,0.6666666666666666,113.259189781412,14.0,15.0,150.39531531531532,5.511315841505439e-30,IgV ligand-binding face,True,assigned_and_evaluated +13367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal capping accessory loops,False,no_term_above_threshold +13368,49045,18.401716,0.97998047,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97998047,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,15.0,0.0,1.0,Conserved beta-propeller blade signature,True,assigned_too_few_test_positives +13369,82029,20.272142,0.96435547,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.65771484,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,1.0,14.0,13.434204596665163,0.11745788724681766,Transmembrane and juxtamembrane helices,True,assigned_too_few_test_positives +13370,85672,18.722792,0.76904297,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7661133,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8155485517034369,0.05727796581627327,0.01595037660611431,,3.591010245759133,1.0,15.0,2.667606263982103,0.4941243364054535,Conserved active-site loop/strand hotspots,True,assigned_and_evaluated +13371,59224,20.188705,0.96240234,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.90234375,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9707619047619047,0.08463372249673226,0.0031014621178555605,,27.28833023930353,0.0,16.0,0.0,1.0,Conserved catalytic beta-strand scaffold,True,assigned_and_evaluated +13372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic helix-loop module,False,no_term_above_threshold +13373,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoskeletal coiled-coil scaffolds,False,no_term_above_threshold +13374,25169,19.346226,0.77246094,pilus,go_cc,25169,pilus,0.77246094,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7921847246891652,0.19612422727176826,0.002215330084182543,0.2,88.5304761904762,0.0,19.0,0.0,1.0,Post-cleavage extracellular edge hotspots,True,assigned_and_evaluated +13375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TRCF/SecA2 mid-sequence motif,False,no_term_above_threshold +13376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-catalytic Gly-Thr strand/loop,False,no_term_above_threshold +13377,87697,17.00778,0.76464844,Knottin,keyword,87697,Knottin,0.76464844,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8153799912140759,0.04793071469707642,0.017279574656623838,,2.77383648900773,0.0,16.0,0.0,1.0,Trp-centered disordered motif,True,assigned_and_evaluated +13378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GlnE ATase junction motifs,False,no_term_above_threshold +13379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-strand signature,False,no_term_above_threshold +13380,30856,16.298664,0.8618164,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.8535156,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7913854351687388,0.008756721861298005,0.002215330084182543,,3.95278424818992,0.0,11.0,0.0,1.0,Transmembrane helix exit interface,True,assigned_and_evaluated +13381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme substrate-binding groove,False,no_term_above_threshold +13382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane amphipathic linkers,False,no_term_above_threshold +13383,50338,23.13141,0.9404297,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.85302734,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Secondary structure entry caps,True,assigned_too_few_test_positives +13384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AAA+ peripheral domains,False,no_term_above_threshold +13385,88058,18.448751,0.6010742,Signal,keyword,88058,Signal,0.6010742,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6181036482322145,0.10654146029273089,0.09127159946832078,,1.167301339226668,4.0,20.0,1.4409909365558913,0.4670478563492871,Disordered low-complexity tails,True,assigned_and_evaluated +13386,55053,21.980637,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,11.0,11.0,552.0462962962963,1.580946100244615e-30,Active-site-proximal beta-loop-helix,True,assigned_too_few_test_positives +13387,64620,16.073225,0.8959961,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.8959961,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,17.0,324.0271739130435,1.225281491287518e-42,HAMP–HisKA S-helix linker,True,assigned_too_few_test_positives +13388,63831,20.703697,0.7734375,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.7734375,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5605656745150304,0.012019251652809995,0.002658396101019052,,4.521241830065359,0.0,11.0,0.0,1.0,N-terminal segment detector,True,assigned_and_evaluated +13389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity localization helices,False,no_term_above_threshold +13390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged surface helix-capping loops,False,no_term_above_threshold +13391,37894,28.997326,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.98046875,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,11.0,645.2489177489177,6.580567677100469e-28,SDR C-terminal substrate lid,True,assigned_too_few_test_positives +13392,24917,18.201338,0.64746094,nucleus,go_cc,24917,nucleus,0.64746094,1728,go,GO:0005634,go_cc:go:GO:0005634,132.0,2257.0,0.8823885918003564,0.2734812798690652,0.05848471422241914,0.015151515151515152,4.676115520185456,9.0,16.0,3.2175777127506477,0.0009394307677618495,Amphipathic helical interfaces,True,assigned_and_evaluated +13393,64003,22.022467,0.9975586,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.7915039,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,130.4617067833698,4.534127311811392e-36,C2H2 zinc finger Cys2-His1 linker,True,assigned_and_evaluated +13394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase accessory helical domains,False,no_term_above_threshold +13395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical oligomerization scaffolds,False,no_term_above_threshold +13396,85762,37.432602,0.8959961,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.8911133,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,17.0,193.49614604462474,6.046250551273022e-36,FAD oxidoreductase internal loop,True,assigned_too_few_test_positives +13397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and disordered tails,False,no_term_above_threshold +13398,38317,16.74859,0.9892578,Pentatricopeptide repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.76708984,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9656507936507935,0.1534000133565132,0.0031014621178555605,,49.46054716366433,0.0,15.0,0.0,1.0,Ser/Thr motif-proximal signal,True,assigned_and_evaluated +13399,85664,21.416563,0.9741211,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9741211,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Glycosyltransferase active-site hinge loop,True,assigned_too_few_test_positives +13400,36668,18.390285,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.97265625,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,17.0,17.0,532.3303571428571,3.538165212749175e-46,Paired ANL scaffold helices,True,assigned_too_few_test_positives +13401,64599,17.962294,0.9785156,Chaperone J-domain superfamily,interpro,64599,Chaperone J-domain superfamily,0.9785156,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,15.0,15.0,662.4555555555555,1.674804095195872e-42,Pre-J leader motif activation,True,assigned_too_few_test_positives +13402,81858,17.566723,0.9326172,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7207031,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic transmembrane helices,True,assigned_too_few_test_positives +13403,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-site clamp/hinge motif,False,no_term_above_threshold +13404,69819,17.15946,0.77734375,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.7685547,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,14.0,14.0,419.86619718309856,5.9822047173573685e-37,C-terminal hydrophobic segment,True,assigned_too_few_test_positives +13405,37430,19.773922,0.8881836,"Signal transduction response regulator, receiver domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.61572266,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,0.0,10.0,0.0,1.0,ABC NBD Walker B linker,True,assigned_too_few_test_positives +13406,37020,16.052925,0.9926758,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9892578,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,15.0,15.0,816.7260273972603,7.478426741552597e-44,NDP-sugar donor-cleft subdomain,True,assigned_too_few_test_positives +13407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short nontransmembrane beta strands,False,no_term_above_threshold +13408,36449,16.993061,0.85791016,EamA domain,interpro,36449,EamA domain,0.85791016,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,17.0,0.0,1.0,Glycosylation portal transmembrane helix,True,assigned_too_few_test_positives +13409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exported cell-wall remodeling domains,False,no_term_above_threshold +13410,87697,19.612259,0.90478516,Knottin,keyword,87413,Disulfide bond,0.9008789,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9860118841182862,0.36468477172893704,0.017279574656623838,,21.10496230236438,1.0,19.0,13.296387154326494,0.11848636014829507,Disulfide-rich extracellular modules,True,assigned_and_evaluated +13411,85672,20.022682,0.62939453,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6269531,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.657836810245635,0.1775160640016642,0.01595037660611431,0.1111111111111111,11.12927101254878,18.0,19.0,37.90808901448251,8.198682763328136e-28,ASCE P-loop ATPase activation,True,assigned_and_evaluated +13412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Immediate mature N-terminus,False,no_term_above_threshold +13413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal interaction tails,False,no_term_above_threshold +13414,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hsp70 NBD AKR[TA]LSS motif,False,no_term_above_threshold +13415,36668,22.944149,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,14.0,14.0,532.3303571428571,2.0509194733270867e-38,ANL adenylation catalytic core,True,assigned_too_few_test_positives +13416,81685,18.803757,0.93603516,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.90234375,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9558834446919078,0.8419901154586229,0.005316792202038104,0.8333333333333334,158.36430754917598,15.0,16.0,80.30845905172414,4.730480697758993e-28,Noncatalytic kinase flanking regions,True,assigned_and_evaluated +13417,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed amphipathic helices,False,no_term_above_threshold +13418,87277,16.135727,0.8388672,Cell outer membrane,keyword,88058,Signal,0.8183594,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.8911746031746033,0.05209071207464055,0.0031014621178555605,,16.795533878923386,0.0,18.0,0.0,1.0,Signal peptide hydrophobic core,True,assigned_and_evaluated +13419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic aromatic proline rich IDRs,False,no_term_above_threshold +13420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal interfacial targeting helix,False,no_term_above_threshold +13421,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PCMH-type FAD-binding core,False,no_term_above_threshold +13422,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Q-centered polar helical motif,False,no_term_above_threshold +13423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged IDR motifs,False,no_term_above_threshold +13424,45290,17.42536,0.90234375,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.90234375,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9273618538324422,0.09575529204944642,0.0057598582188746125,,16.62459185812312,0.0,16.0,0.0,1.0,Conserved acidic DNA-binding patches,True,assigned_and_evaluated +13425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular β-sandwich/jellyroll detector,False,no_term_above_threshold +13426,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class II aaRS catalytic cores,False,no_term_above_threshold +13427,64620,20.372509,0.96533203,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.96533203,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,11.0,19.0,187.5946796338673,3.747955091314207e-23,Terminase nuclease and GHKL ATPases,True,assigned_too_few_test_positives +13428,45324,18.072367,0.9160156,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.7241211,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9995559502664298,0.71,0.002215330084182543,1.0,320.494,10.0,16.0,341.86353211009174,6.349631964772938e-24,Extracellular beta-solenoid repeats,True,assigned_and_evaluated +13429,46078,20.242903,0.984375,Armadillo-like helical,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.90722656,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,19.0,19.0,130.74780701754386,3.676010515894859e-40,Alpha-solenoid repeat junctions,True,assigned_too_few_test_positives +13430,87545,15.830775,0.7597656,Hemolysis,keyword,87162,Antimicrobial,0.66552734,102,keywords,Hemolysis,keyword:keywords:Hemolysis,8.0,2257.0,0.9884670964873278,0.13765429015429015,0.003544528134692069,,38.83571660977911,1.0,20.0,12.849353448275863,0.12234985799709379,Hydrophobic helical interaction faces,True,assigned_and_evaluated +13431,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved acidic CoA-adjacent motif,False,no_term_above_threshold +13432,87413,26.33248,0.6308594,Disulfide bond,keyword,88058,Signal,0.61621094,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.6096452458823182,0.16033585920252932,0.0717766947275144,0.018518518518518517,2.2338150260500536,5.0,19.0,3.1124254794892408,0.030932534671471116,Surface-exposed beta-strand edges,True,assigned_and_evaluated +13433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic TM-flanking cytosolic IDRs,False,no_term_above_threshold +13434,38317,17.795155,0.73046875,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.73046875,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6321904761904762,0.022572472941325403,0.0031014621178555605,,7.2780102040816335,0.0,12.0,0.0,1.0,N-cap anion-binding helix,True,assigned_and_evaluated +13435,36104,19.65127,0.96972656,Rho GTPase-activating protein domain,interpro,36409,"Zinc finger, CCCH-type",0.8613281,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Extracellular glycine-rich glycan-binding loops,True,assigned_too_few_test_positives +13436,82029,17.488464,0.8823242,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.69433594,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic transmembrane alpha-helices,True,assigned_too_few_test_positives +13437,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NAE1 UBA3-interface central helix,False,no_term_above_threshold +13438,82029,28.745485,0.921875,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.91503906,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,17.0,188.0788643533123,1.0133225259294918e-38,MFS intracellular loop signature,True,assigned_too_few_test_positives +13439,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA methyltransferase RNA-binding interface,False,no_term_above_threshold +13440,82597,19.05354,0.8803711,Tetratricopeptide repeat domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7832031,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9172151378033729,0.03459465422040135,0.0057598582188746125,,6.006164198111219,0.0,18.0,0.0,1.0,Helix C-cap boundary motif,True,assigned_and_evaluated +13441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved folded regulatory domain cores,False,no_term_above_threshold +13442,36104,17.103674,0.7504883,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.7504883,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,ETF-like FAD-binding flavoenzymes,True,assigned_too_few_test_positives +13443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal upstream-domain activation,False,no_term_above_threshold +13444,2772,16.515915,0.9223633,2.4.-.-,ec,58239,P-loop containing nucleoside triphosphate hydrolase,0.6723633,46,ec,2.4.-.-,ec:ec:2.4.-.-,,,,,,,,0.0,15.0,0.0,1.0,Two-component receiver domains,True,assigned_too_few_test_positives +13445,8200,16.934822,0.67578125,proteolysis,go_bp,87601,Hydrolase,0.6201172,331,go,GO:0006508,go_bp:go:GO:0006508,24.0,2257.0,0.6810997910135841,0.02815673136928039,0.010633584404076208,,2.647905945852743,5.0,15.0,16.066019940716785,1.799383513190199e-05,Secreted hydrolase β-sheet scaffold,True,assigned_and_evaluated +13446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular loop functional hotspots,False,no_term_above_threshold +13447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad periplasmic/SYLF activation,False,no_term_above_threshold +13448,37446,16.509104,0.91308594,F-box domain,interpro,29166,zinc ion binding,0.8442383,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.964,0.07850622822212629,0.0031014621178555605,,25.312651013905576,0.0,19.0,0.0,1.0,HTH loops and Zn/His coordination,True,assigned_and_evaluated +13449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-biased alpha-helix detector,False,no_term_above_threshold +13450,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal PYxx(L/V)E motif,False,no_term_above_threshold +13451,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular low-complexity linkers,False,no_term_above_threshold +13452,88161,50.760532,0.7363281,Transmembrane helix,keyword,88161,Transmembrane helix,0.7363281,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7474246689604838,0.5322744499281642,0.1847585290208241,0.48201438848920863,2.8809195047670664,14.0,14.0,5.4274920345926265,1.0920821671226735e-10,Transmembrane helix functional micro-sites,True,assigned_and_evaluated +13453,36091,21.44069,0.95458984,GNAT domain,interpro,36091,GNAT domain,0.95458984,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,11.0,0.0,1.0,Post-LSGGQ signature-helix residue,True,assigned_too_few_test_positives +13454,69819,16.443768,0.80371094,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.7792969,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,15.0,15.0,419.86619718309856,1.6608451341010338e-39,ATP-utilizing lid/hinge subdomain,True,assigned_too_few_test_positives +13455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal aromatic-acidic CAZyme patch,False,no_term_above_threshold +13456,45288,15.817244,0.9819336,CheY-like superfamily,interpro,82029,MFS general substrate transporter like domains,0.8774414,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,13.0,13.0,462.17829457364337,6.281107742864664e-35,REC alpha5 docking interface,True,assigned_too_few_test_positives +13457,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet surface detector,False,no_term_above_threshold +13458,52236,24.768108,0.99853516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9941406,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR register detector,True,assigned_too_few_test_positives +13459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal S/T/P-rich regulatory IDRs,False,no_term_above_threshold +13460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BRCT domains and interaction motifs,False,no_term_above_threshold +13461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor and transducer helix hotspots,False,no_term_above_threshold +13462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-sandwich interaction face,False,no_term_above_threshold +13463,36091,28.710503,1.0,GNAT domain,interpro,85712,3.40.630.30,0.97558594,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase CA G2-box,True,assigned_too_few_test_positives +13464,8103,19.669136,0.7890625,regulation of transcription by RNA polymerase II,go_bp,88150,Transcription regulation,0.64208984,264,go,GO:0006357,go_bp:go:GO:0006357,25.0,2257.0,0.8247043010752689,0.17534674363665206,0.011076650420912717,,15.830304015516948,9.0,17.0,19.211234828684972,3.726618702957394e-10,Broad activation of transcriptional co-regulators,True,assigned_and_evaluated +13465,47531,16.2487,0.74121094,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.74121094,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,13.0,17.0,193.18868394815553,3.3745859172794014e-28,Anion-binding active-site surface,True,assigned_too_few_test_positives +13466,30398,22.762981,0.7158203,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.6923828,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6767789201003805,0.29401055302694645,0.004873726185201595,0.2727272727272727,60.32561983471074,7.0,7.0,72.00603864734299,2.1827814896242549e-13,ABC Walker A N-terminal edge,True,assigned_and_evaluated +13467,58239,40.873425,0.78564453,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78564453,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7543583671628326,0.3470714864077233,0.017722640673460344,0.375,19.583508620555786,18.0,18.0,35.851473241130485,3.2784535000502832e-28,NMP-kinase substrate-binding loop,True,assigned_and_evaluated +13468,37894,23.779873,0.9604492,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.9604492,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,Conserved SDR C-terminal helix,True,assigned_too_few_test_positives +13469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-boundary Ser/Thr SLiMs,False,no_term_above_threshold +13470,47717,15.679556,0.95654297,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.77783203,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,11.0,0.0,1.0,ABC NBD loop-to-strand signal,True,assigned_too_few_test_positives +13471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfotransferase catalytic core motif,False,no_term_above_threshold +13472,85649,23.165573,0.68408203,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.68115234,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6038885212720408,0.05822143963626501,0.0101905183872397,,5.713295185176093,11.0,11.0,110.61410018552876,8.372133250060158e-23,Methyltransferase N-terminal recruitment segments,True,assigned_and_evaluated +13473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor helix–loop junction,False,no_term_above_threshold +13474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Prenyltransferase C-terminal helical bundle,False,no_term_above_threshold +13475,-1,,,,,-1,,,0,,,,,,,,,,,,,,,c-type cytochrome domain scaffold,False,no_term_above_threshold +13476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FIC/Doc catalytic core,False,no_term_above_threshold +13477,37282,20.277029,0.9848633,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.9394531,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,13.0,13.0,223.29962546816478,8.540372701722431e-31,LRR–TM juxtamembrane hinge,True,assigned_too_few_test_positives +13478,37894,24.524462,0.80566406,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.80566406,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,1.0,19.0,37.356516290726816,0.044180464377624094,Rossmann glycine-loop oxidoreductases,True,assigned_too_few_test_positives +13479,72011,19.437689,0.9902344,"AMP-binding enzyme, C-terminal domain superfamily",interpro,64058,NAD(P)-binding domain superfamily,0.70410156,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,1.0,8.0,73.78836633663367,0.022869300453825687,Substrate-gating loop residues,True,assigned_too_few_test_positives +13480,88058,20.04445,0.6245117,Signal,keyword,88058,Signal,0.6245117,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.5771267153602553,0.10150074694549625,0.09127159946832078,,1.1120737177475002,6.0,20.0,2.1614864048338367,0.08048950337413811,Alanine and small-residue enrichment,True,assigned_and_evaluated +13481,87239,15.847574,0.77001953,CF(1),keyword,87239,CF(1),0.77001953,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9995529727313366,0.8723654430794524,0.008861320336730172,1.0,98.44644025151621,0.0,13.0,0.0,1.0,EAL-domain c-di-GMP PDE core,True,assigned_and_evaluated +13482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-adjacent interfacial amphipathic helices,False,no_term_above_threshold +13483,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate handling enzyme signature,False,no_term_above_threshold +13484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic low-complexity linker motifs,False,no_term_above_threshold +13485,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane accessory beta segments,False,no_term_above_threshold +13486,81540,15.933779,1.0,"Tetracycline Repressor, domain 2",gene3d,27918,DNA-binding transcription factor activity,0.6274414,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,18.0,18.0,828.0694444444445,8.045771561914299e-52,Alpha-helical HTH hinge helix,True,assigned_too_few_test_positives +13487,25169,15.6644125,0.77685547,pilus,go_cc,25169,pilus,0.77685547,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.694804618117229,0.2513291980505095,0.002215330084182543,0.2,113.45,0.0,16.0,0.0,1.0,C-terminal domain/tail detector,True,assigned_and_evaluated +13488,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate/metal-binding catalytic scaffold,False,no_term_above_threshold +13489,64620,16.051676,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.94873047,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,17.0,324.0271739130435,1.225281491287518e-42,Histidine kinase ATP-lid helix,True,assigned_too_few_test_positives +13490,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal post-catalytic cap helix,False,no_term_above_threshold +13491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Pro/Thr-rich disordered linkers,False,no_term_above_threshold +13492,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ketosynthase/condensing enzyme fold,False,no_term_above_threshold +13493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic interhelical YDIYR motif,False,no_term_above_threshold +13494,45553,19.26456,0.97753906,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.9238281,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,2.0,18.0,76.14431673052363,0.0005676923219839566,Nuclease beta-loop-alpha gateway,True,assigned_too_few_test_positives +13495,49061,22.458027,0.9604492,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9604492,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9832243799269371,0.25413342480560214,0.012405848471422242,,20.484969278080143,3.0,17.0,17.44834650278022,0.0011141074669768613,Conserved beta-strand core residues,True,assigned_and_evaluated +13496,64168,25.765364,0.8779297,HAD-like superfamily,interpro,64168,HAD-like superfamily,0.8779297,38,ip,IPR036412,interpro:ip:IPR036412,5.0,2257.0,0.8959147424511545,0.6280292729133883,0.002215330084182543,0.6,283.4924137931035,16.0,17.0,315.24653007270325,2.629538460338397e-39,Plant SPS C-terminal motif,True,assigned_and_evaluated +13497,69819,23.990599,0.8676758,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.84814453,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,Carbohydrate kinase hinge loop,True,assigned_too_few_test_positives +13498,72011,16.442923,0.93847656,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36977,"Serine-threonine/tyrosine-protein kinase, catalytic domain",0.89501953,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,c-di-GMP enzyme catalytic motifs,True,assigned_too_few_test_positives +13499,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDR and helical scaffolds,False,no_term_above_threshold +13500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic regulatory interaction regions,False,no_term_above_threshold +13501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,T2SS/PilC N-terminus central TM,False,no_term_above_threshold +13502,37894,21.532578,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.90478516,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,15.0,16.0,665.4129464285714,7.848216272787399e-42,Rossmann NAD(P)H binding loop,True,assigned_too_few_test_positives +13503,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Molybdoflavoenzyme internal linker,False,no_term_above_threshold +13504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal capping helix,False,no_term_above_threshold +13505,45714,17.59426,0.97802734,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,85664,Glycogen Phosphorylase B;,0.9526367,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,13.0,0.0,1.0,HAMP/DHp coiled-coil helices,True,assigned_too_few_test_positives +13506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic active-site lid loops,False,no_term_above_threshold +13507,36104,21.166176,0.9296875,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9296875,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Pre-heme-binding motif segment,True,assigned_too_few_test_positives +13508,87413,47.37685,0.87060547,Disulfide bond,keyword,87413,Disulfide bond,0.87060547,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.908435722914641,0.3632618772803656,0.0717766947275144,0.030864197530864196,5.061000351986328,12.0,18.0,7.884811214706077,3.0866755414586076e-09,Secreted and viral disordered loops,True,assigned_and_evaluated +13509,49236,22.722708,0.90771484,C-type lectin fold,interpro,49236,C-type lectin fold,0.90771484,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9995559502664298,0.71,0.002215330084182543,1.0,320.494,5.0,18.0,150.5580808080808,3.4221140723972024e-10,C-type lectin carbohydrate-recognition loop,True,assigned_and_evaluated +13510,37894,19.885746,0.765625,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.63623047,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,13.0,436.7838827838828,3.6800818758855133e-20,C-terminal lid/stalk helix,True,assigned_too_few_test_positives +13511,85649,22.365929,0.70458984,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7011719,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.620382624265307,0.15633595003741682,0.0101905183872397,0.13043478260869565,15.341314749323901,15.0,15.0,110.61410018552876,7.1622047874657735e-31,Class I methyltransferase C-terminal lid,True,assigned_and_evaluated +13512,36091,26.246284,0.99560547,GNAT domain,interpro,85712,3.40.630.30,0.9477539,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,17.0,0.0,1.0,Histidine kinase CA helix,True,assigned_too_few_test_positives +13513,88161,30.306282,0.65283203,Transmembrane helix,keyword,88161,Transmembrane helix,0.65283203,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7182228130539048,0.5535230221588603,0.1847585290208241,0.47002398081534774,2.9959267650181,14.0,16.0,4.749055530268548,8.626851513742047e-09,Cytochrome b559 alpha lumenal motif,True,assigned_and_evaluated +13514,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Binding-adjacent capping motifs,False,no_term_above_threshold +13515,50806,23.646366,0.9223633,"Homeobox, conserved site",interpro,87566,Homeobox,0.8515625,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,15.0,0.0,1.0,ABC TMD–NBD coupling linker,True,assigned_too_few_test_positives +13516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-rich regulatory IDRs,False,no_term_above_threshold +13517,37314,17.147577,0.99658203,"Helicase, C-terminal domain-like",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.609375,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,13.0,13.0,317.1329787234043,8.872044943575978e-33,RecA-like helicase core activation,True,assigned_too_few_test_positives +13518,45317,15.883971,0.94921875,"Six-bladed beta-propeller, TolB-like",interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.80078125,27,ip,IPR011042,interpro:ip:IPR011042,,,,,,,,7.0,18.0,297.255698005698,3.7433154085055503e-16,Beta-propeller blade motifs,True,assigned_too_few_test_positives +13519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase active-site loop motif,False,no_term_above_threshold +13520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal peptidoglycan-binding segments,False,no_term_above_threshold +13521,46082,17.627697,0.9628906,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9628906,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9987936507936508,0.7124999999999999,0.0031014621178555605,0.8571428571428571,229.73035714285712,15.0,15.0,150.93924050632913,7.117153535323136e-33,PH-flanking polybasic disordered tails,True,assigned_and_evaluated +13522,45272,25.45664,0.95654297,"Lambda repressor-like, DNA-binding domain superfamily",interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.95654297,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,0.0,9.0,0.0,1.0,Helical packing and NTPase switches,True,assigned_too_few_test_positives +13523,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-termini of secreted ligands,False,no_term_above_threshold +13524,36449,17.019287,0.9135742,EamA domain,interpro,82029,MFS general substrate transporter like domains,0.8027344,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,16.0,0.0,1.0,Pore-lining transmembrane helix caps,True,assigned_too_few_test_positives +13525,49116,21.671232,0.96875,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.96875,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9978685612788633,0.6041666666666667,0.002215330084182543,0.4,272.72083333333336,15.0,20.0,65.27846715328467,3.0792553979016777e-25,Scattered peaks on repeat scaffolds,True,assigned_and_evaluated +13526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-basic pi-stacking pocket,False,no_term_above_threshold +13527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ORF2p C-terminal RNA-binding helices,False,no_term_above_threshold +13528,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar/charged helical surfaces,False,no_term_above_threshold +13529,25169,18.575594,0.81591797,pilus,go_cc,25169,pilus,0.81591797,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8813943161634102,0.045187343246842857,0.002215330084182543,,20.397566741624868,0.0,15.0,0.0,1.0,Lectin-like beta-sandwich strands,True,assigned_and_evaluated +13530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity docking segments,False,no_term_above_threshold +13531,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrolase active-site-adjacent loops,False,no_term_above_threshold +13532,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pepsin/retropepsin aspartic proteases,False,no_term_above_threshold +13533,38317,20.904856,0.86328125,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.86328125,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7811111111111111,0.34362975463678036,0.0031014621178555605,0.2857142857142857,110.7960508878876,0.0,11.0,0.0,1.0,Single-pass receptor cap and TM,True,assigned_and_evaluated +13534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Deaminase and nuclease catalytic cores,False,no_term_above_threshold +13535,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha junction binding patch,False,no_term_above_threshold +13536,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DSVDLxLEAK periplasmic motif,False,no_term_above_threshold +13537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT/RdRp primer-grip/thumb region,False,no_term_above_threshold +13538,85656,17.468386,0.9316406,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7758789,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9807936507936509,0.1477024878672782,0.0031014621178555605,,47.62350215949241,3.0,17.0,24.932115974351827,0.00040037959353151573,Pocket-lining strand-edge loops,True,assigned_and_evaluated +13539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SAC-domain phosphoinositide phosphatases,False,no_term_above_threshold +13540,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic core TM helices,False,no_term_above_threshold +13541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann NAD(P) cofactor-binding subdomain,False,no_term_above_threshold +13542,49116,23.011675,0.96875,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.96875,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9982238010657194,0.700952380952381,0.002215330084182543,0.8,316.4099047619048,14.0,19.0,64.13323088743756,1.9386379356214602e-23,HEAT/ARM/TPR alpha-solenoids,True,assigned_and_evaluated +13543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered activation domains,False,no_term_above_threshold +13544,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Presequence-to-mature boundary detector,False,no_term_above_threshold +13545,85656,19.743475,0.92626953,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7426758,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9871746031746031,0.12358444782798349,0.0031014621178555605,,39.84715696396553,0.0,18.0,0.0,1.0,Hydrophobic alpha-helix packing segments,True,assigned_and_evaluated +13546,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal accessory segment detector,False,no_term_above_threshold +13547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyprenol-linked glycosyltransferase TM core,False,no_term_above_threshold +13548,87697,17.71904,0.83984375,Knottin,keyword,87697,Knottin,0.83984375,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7218041201359505,0.029220028644214652,0.017279574656623838,,1.6910155038459607,0.0,15.0,0.0,1.0,N-terminal disordered SLiMs,True,assigned_and_evaluated +13549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,EAL PDE active-site core,False,no_term_above_threshold +13550,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Gly-rich C-terminal interaction modules,False,no_term_above_threshold +13551,46082,17.12445,0.9824219,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9824219,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9996825396825397,0.9214285714285713,0.0031014621178555605,1.0,297.09489795918364,8.0,15.0,80.5009282700422,4.8949825760569194e-14,PH-domain phosphoinositide-binding surfaces,True,assigned_and_evaluated +13552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase DHp transmitter core,False,no_term_above_threshold +13553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved GOGAT C-terminal motif,False,no_term_above_threshold +13554,72011,17.849161,0.9980469,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.94189453,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,6.0,16.0,221.365099009901,3.5921413659180214e-13,Acidic beta-propeller cores,True,assigned_too_few_test_positives +13555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue disordered low-complexity repeats,False,no_term_above_threshold +13556,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +13557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible small/acidic active-site loops,False,no_term_above_threshold +13558,85682,17.093605,0.6298828,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6298828,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7525627240143369,0.2534387800939717,0.011076650420912717,0.2,22.880453066883764,11.0,11.0,102.26586620926243,1.9706816312537337e-22,Rossmann-fold substrate-binding subdomain,True,assigned_and_evaluated +13559,48255,16.11964,0.74609375,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.74609375,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,14.0,15.0,317.9786666666667,1.5298751391190108e-34,Adenylation-linked sulfur-transfer enzymes,True,assigned_too_few_test_positives +13560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-cap motif,False,no_term_above_threshold +13561,47531,19.368538,0.8227539,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.8227539,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,11.0,15.0,185.2629943502825,1.1536866250132997e-23,Alpha/beta TIM-barrel catalytic core,True,assigned_too_few_test_positives +13562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical rods and scaffolds,False,no_term_above_threshold +13563,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VGINTD-like boundary motif,False,no_term_above_threshold +13564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fae catalytic His/Asp focus,False,no_term_above_threshold +13565,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/regulatory segments,False,no_term_above_threshold +13566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-prone low-complexity IDRs,False,no_term_above_threshold +13567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral replication accessory regions,False,no_term_above_threshold +13568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase-coupled beta-strand nuclease scaffold,False,no_term_above_threshold +13569,52940,18.00059,0.9790039,"AMP-binding, conserved site",interpro,36668,AMP-dependent synthetase/ligase domain,0.94091797,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,1.0,16.0,38.02359693877551,0.04344145960883729,Helix-coil interface patches,True,assigned_too_few_test_positives +13570,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded viral protein cores,False,no_term_above_threshold +13571,45290,17.134466,0.7338867,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7338867,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7025058275058276,0.03361781018923584,0.0057598582188746125,,5.836569045931176,0.0,12.0,0.0,1.0,ATP-adjacent helix-loop-beta lid,True,assigned_and_evaluated +13572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended charged interaction surfaces,False,no_term_above_threshold +13573,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent DNA primase core,False,no_term_above_threshold +13574,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β–loop–α pocket-wall clamp,False,no_term_above_threshold +13575,37341,17.36013,0.96728516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9614258,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9959142999501744,0.6204432060796777,0.011962782454585734,0.8518518518518519,51.864456152660466,0.0,16.0,0.0,1.0,Ig/FNIII and WD strand-loop edges,True,assigned_and_evaluated +13576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic recognition helices,False,no_term_above_threshold +13577,85649,20.312925,0.6640625,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6616211,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6251021758592503,0.17087545062205273,0.0101905183872397,0.17391304347826086,16.768082263216215,10.0,16.0,69.13381261595546,6.22413232917555e-17,Glycine-rich adenosyl-binding loop,True,assigned_and_evaluated +13578,64003,22.360186,0.99609375,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.8979492,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,11.0,11.0,130.4617067833698,1.3724628209314255e-23,C2H2 zinc finger ligands,True,assigned_and_evaluated +13579,85682,24.993353,0.67041016,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.67041016,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7091129032258063,0.15458581913456348,0.011076650420912717,0.08,13.956007751468391,13.0,14.0,94.9611614800294,2.7710605294371066e-25,E1 adenylation and RCK domains,True,assigned_and_evaluated +13580,87697,17.191814,0.81884766,Knottin,keyword,87413,Disulfide bond,0.61865234,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8066114078287205,0.04269923429374911,0.017279574656623838,,2.4710813282305573,0.0,19.0,0.0,1.0,Fold-agnostic interface hotspot detector,True,assigned_and_evaluated +13581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transporter N-termini and disordered loops,False,no_term_above_threshold +13582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal acidic disordered tail,False,no_term_above_threshold +13583,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic LysM low-complexity linkers,False,no_term_above_threshold +13584,87239,15.945461,0.75878906,CF(1),keyword,87239,CF(1),0.75878906,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9987036209208762,0.7543024006163392,0.008861320336730172,1.0,85.12302590955389,0.0,18.0,0.0,1.0,Lumenal disulfide-stabilized catalytic core,True,assigned_and_evaluated +13585,38317,18.21328,0.7919922,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7919922,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6856825396825397,0.015114561073628043,0.0031014621178555605,,4.873366334739785,0.0,12.0,0.0,1.0,N-proximal PLP small-domain motif,True,assigned_and_evaluated +13586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gating-loop activation,False,no_term_above_threshold +13587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved beta-strand interface patch,False,no_term_above_threshold +13588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charge-biased low-complexity scaffolds,False,no_term_above_threshold +13589,64620,16.941141,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,36914,Glycosyltransferase 2-like,0.93603516,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,Bergerat-fold G1 glycine loop,True,assigned_too_few_test_positives +13590,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral RdRp palm catalytic core,False,no_term_above_threshold +13591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal regulatory appendages,False,no_term_above_threshold +13592,85762,31.015535,0.91259766,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.89941406,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,17.0,193.49614604462474,6.046250551273022e-36,Rossmann FAD-binding flavoprotein core,True,assigned_too_few_test_positives +13593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal transducer regions,False,no_term_above_threshold +13594,85364,23.075563,0.86572266,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.86572266,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,SBP/TRAP ligand-binding cleft,True,assigned_too_few_test_positives +13595,50806,17.1034,0.9980469,"Homeobox, conserved site",interpro,64146,Winged helix-like DNA-binding domain superfamily,0.93652344,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,HTH DNA-binding core residues,True,assigned_too_few_test_positives +13596,37291,16.388508,0.84814453,DnaJ domain,interpro,37291,DnaJ domain,0.84814453,25,ip,IPR001623,interpro:ip:IPR001623,,,,,,,,0.0,16.0,0.0,1.0,Phosphate-binding cap/loop motif,True,assigned_too_few_test_positives +13597,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane processing modules,False,no_term_above_threshold +13598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-tunnel helix/loop,False,no_term_above_threshold +13599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich loops and linkers,False,no_term_above_threshold +13600,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Trp/Cys-rich ECL1 loops,False,no_term_above_threshold +13601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA phosphodiester catalytic cores,False,no_term_above_threshold +13602,87276,25.998201,0.6010742,Cell membrane,keyword,87276,Cell membrane,0.6010742,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7192883500891748,0.414348447008863,0.11120957022596367,0.4701195219123506,3.7258344418287,16.0,17.0,7.722802415763994,8.007539238073717e-14,TM boundary helix-loop-helix junctions,True,assigned_and_evaluated +13603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RAD52-like ssDNA-annealing domain,False,no_term_above_threshold +13604,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD superfamily inter-HKD segment,False,no_term_above_threshold +13605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered linkers and coiled coils,False,no_term_above_threshold +13606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane bundle and loops,False,no_term_above_threshold +13607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered turn/cap sites,False,no_term_above_threshold +13608,59224,19.169104,0.92089844,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8823242,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9518730158730159,0.03587343617022955,0.0031014621178555605,,11.566620776601155,0.0,18.0,0.0,1.0,Receiver-domain beta4-alpha4 Pro loop,True,assigned_and_evaluated +13609,82029,30.717691,0.9995117,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9863281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Paired MFS gating loops,True,assigned_too_few_test_positives +13610,43583,15.7817,0.88378906,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.88378906,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,0.9998785720068,0.9805194805194805,0.004873726185201595,1.0,201.18476977567886,10.0,10.0,416.9300699300699,1.4595016026239996e-26,Serine protease catalytic core,True,assigned_and_evaluated +13611,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered acidic receptor C-termini,False,no_term_above_threshold +13612,88161,36.33554,0.60302734,Transmembrane helix,keyword,88161,Transmembrane helix,0.60302734,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6337380095923261,0.382302762832274,0.1847585290208241,0.3261390887290168,2.06920224391473,14.0,14.0,5.4274920345926265,1.0920821671226735e-10,Membrane-proximal soluble domains,True,assigned_and_evaluated +13613,43624,32.160458,0.97314453,Homedomain-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9379883,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.9822066041945561,0.18611389970523526,0.007089056269384138,,26.253691977169748,0.0,17.0,0.0,1.0,HTH/WH N-terminal positioning helix,True,assigned_and_evaluated +13614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Core helices and strand starts,False,no_term_above_threshold +13615,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-loop-beta junction recognition,False,no_term_above_threshold +13616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical accessory domains,False,no_term_above_threshold +13617,82029,18.475208,0.9453125,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8510742,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,14.0,0.0,1.0,Hydrophobic transmembrane alpha helices,True,assigned_too_few_test_positives +13618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic alpha-helix signature,False,no_term_above_threshold +13619,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic domain activation,False,no_term_above_threshold +13620,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class II aaRS C-terminal subdomain,False,no_term_above_threshold +13621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hinge/kink residue detector,False,no_term_above_threshold +13622,36535,23.90552,0.9785156,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.96875,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.948931909212283,0.9004430660168364,0.004430660168365086,0.9,203.23,16.0,16.0,89.79066265060241,1.9255645614704107e-31,Kinase C-lobe G-helix,True,assigned_and_evaluated +13623,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DHp coiled-coil hairpin,False,no_term_above_threshold +13624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-domain specificity loops,False,no_term_above_threshold +13625,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell-wall/glycan binders and linkers,False,no_term_above_threshold +13626,87913,15.797078,0.7636719,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.7636719,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8910738169543341,0.7007593974807089,0.006202924235711121,0.6428571428571429,112.97242572242571,14.0,17.0,395.96489563567354,4.648772044577234e-35,Ketosynthase active-site perimeter,True,assigned_and_evaluated +13627,49061,24.142673,0.97753906,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.97753906,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.994263923604435,0.48010233911542644,0.012405848471422242,1.0,38.69967783512562,11.0,16.0,67.97584991708126,1.0814971666553603e-18,Beta-propeller strand N-cap detector,True,assigned_and_evaluated +13628,85649,47.02377,0.9770508,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9746094,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8897571133860106,0.7579510127431446,0.0101905183872397,0.782608695652174,74.37806242440335,16.0,16.0,110.61410018552876,7.117153535323136e-33,Rossmann SAM-binding loop,True,assigned_and_evaluated +13629,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Small-protein detector, catalytic hotspots",False,no_term_above_threshold +13630,87852,16.305157,0.81152344,Nucleosome core,keyword,87852,Nucleosome core,0.81152344,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,15.0,0.0,1.0,Actinobacterial envelope targeting segments,True,assigned_too_few_test_positives +13631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SH3/SH3b fold detector,False,no_term_above_threshold +13632,88160,16.648663,0.86572266,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7207031,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,16.0,17.0,272.3974871501999,2.673694221541573e-38,Outer-membrane beta-barrel junction motifs,True,assigned_too_few_test_positives +13633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site proton-donor loop motif,False,no_term_above_threshold +13634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged terminal helical tail,False,no_term_above_threshold +13635,38317,22.004091,0.7998047,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7998047,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6329523809523809,0.017676059830626575,0.0031014621178555605,,5.699266719674883,0.0,17.0,0.0,1.0,Isoprenoid acidic catalytic motifs,True,assigned_and_evaluated +13636,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix C-terminal capping motif,False,no_term_above_threshold +13637,87697,17.196009,0.7314453,Knottin,keyword,87697,Knottin,0.7314453,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7995017456243787,0.04522174596963616,0.017279574656623838,,2.6170636064992,0.0,16.0,0.0,1.0,Conserved beta-strand edge hotspots,True,assigned_and_evaluated +13638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate/oxyanion-binding loops,False,no_term_above_threshold +13639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Actinobacterial Ser/Thr kinase domain activation,False,no_term_above_threshold +13640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal tails and aliphatic anchors,False,no_term_above_threshold +13641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TRAPP subunit N-terminal hotspot,False,no_term_above_threshold +13642,64620,17.376707,0.9824219,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.9824219,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,15.0,17.0,285.90632992327363,9.010865335320971e-36,Catalytic-site helix-start switch,True,assigned_too_few_test_positives +13643,37020,16.908077,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9707031,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,16.0,816.7260273972603,1.3609527499980455e-46,Nucleotide-sugar donor-binding helix,True,assigned_too_few_test_positives +13644,88147,17.032064,0.63671875,Toxin-antitoxin system,keyword,88147,Toxin-antitoxin system,0.63671875,120,keywords,Toxin-antitoxin system,keyword:keywords:Toxin-antitoxin system,10.0,2257.0,0.6955051179350245,0.3293250627676857,0.004430660168365086,0.3,74.32866666666666,0.0,17.0,0.0,1.0,Structure-specific nuclease core fold,True,assigned_and_evaluated +13645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic interface module,False,no_term_above_threshold +13646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intra-domain strand/coil transitions,False,no_term_above_threshold +13647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helix-loop motif,False,no_term_above_threshold +13648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interdomain S-helix signal relay,False,no_term_above_threshold +13649,64148,18.29347,0.65185547,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.65185547,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5756549550820752,0.1176153720588578,0.008418254319893664,0.15789473684210525,13.97146814404432,19.0,19.0,88.9865671641791,4.383349844353145e-37,HTH effector βαβ module,True,assigned_and_evaluated +13650,85672,19.543701,0.6152344,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61279297,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6211603882135175,0.11031886310233305,0.01595037660611431,,6.916379833943492,5.0,10.0,20.007046979865773,4.1830666723973525e-06,Conserved nucleotide-binding catalytic cores,True,assigned_and_evaluated +13651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket-lining loops,False,no_term_above_threshold +13652,88118,15.821209,0.8017578,Target cell membrane,keyword,87162,Antimicrobial,0.6845703,92,keywords,Target cell membrane,keyword:keywords:Target cell membrane,9.0,2257.0,0.9293693159351522,0.12969920483179884,0.003987594151528578,,32.52567836726333,0.0,19.0,0.0,1.0,Membrane-active amphipathic helices,True,assigned_and_evaluated +13653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase N-domain ATP-binding site,False,no_term_above_threshold +13654,37690,31.981846,0.9970703,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9970703,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9994920634920635,0.8333333333333333,0.0031014621178555605,1.0,268.69047619047615,18.0,18.0,180.66969696969696,1.390790500677779e-40,Ankyrin repeat linker loop,True,assigned_and_evaluated +13655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal β-strand interfaces,False,no_term_above_threshold +13656,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular accessory binding domains,False,no_term_above_threshold +13657,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity α-helical assembly interface,False,no_term_above_threshold +13658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal periplasmic loops,False,no_term_above_threshold +13659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Compact structural segment hotspot,False,no_term_above_threshold +13660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Whole-chain activation with β-strand peaks,False,no_term_above_threshold +13661,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enzyme catalytic core signature,False,no_term_above_threshold +13662,69819,23.905949,0.8535156,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.83447266,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,15.0,16.0,393.6245598591549,2.340834909685762e-38,Acidic peripheral C-terminal caps,True,assigned_too_few_test_positives +13663,87108,19.580265,0.9614258,ANK repeat,keyword,88009,Repeat,0.6713867,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9206702253855279,0.03368999187040093,0.003987594151528578,,8.448701294610544,0.0,16.0,0.0,1.0,Receiver-domain leucine core,True,assigned_and_evaluated +13664,45324,21.74085,0.94628906,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.94628906,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9993783303730018,0.6595238095238095,0.002215330084182543,1.0,297.7090476190476,6.0,13.0,252.4530698659139,1.249638634892804e-13,Glycine-rich low-complexity coils,True,assigned_and_evaluated +13665,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DLHAxT post-HIGH loop,False,no_term_above_threshold +13666,38317,16.0453,0.91552734,Pentatricopeptide repeat,interpro,88009,Repeat,0.65234375,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8291428571428572,0.09853027532999023,0.0031014621178555605,,31.768975917112563,0.0,17.0,0.0,1.0,Eukaryotic pre-WD40 interaction region,True,assigned_and_evaluated +13667,37690,24.04854,0.9868164,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.984375,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9900952380952381,0.28454769867813345,0.0031014621178555605,0.5714285714285714,91.74630798807817,0.0,14.0,0.0,1.0,SDR Rossmann NAD(P) pocket,True,assigned_and_evaluated +13668,87852,21.108564,0.93652344,Nucleosome core,keyword,24789,nucleosome,0.88964844,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,15.0,0.0,1.0,Polybasic disordered terminal tails,True,assigned_too_few_test_positives +13669,59224,31.355299,0.97216797,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97216797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9964126984126984,0.30969407576550434,0.0031014621178555605,,99.85421842896332,0.0,18.0,0.0,1.0,SAM-MTase catalytic micro-motifs,True,assigned_and_evaluated +13670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RG-rich internal loops,False,no_term_above_threshold +13671,38890,17.071898,0.8071289,HNH nuclease,interpro,38890,HNH nuclease,0.8071289,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,8.0,20.0,518.4434782608696,2.1644944042450656e-20,HNH endonuclease domain detector,True,assigned_too_few_test_positives +13672,87857,27.634094,0.70996094,Nucleus,keyword,87857,Nucleus,0.70996094,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.6886856641059674,0.20460418338107303,0.06247230837394772,0.11347517730496454,3.275118027596325,11.0,16.0,4.165593241869918,8.954506678607137e-06,Disordered nuclear regulatory segments,True,assigned_and_evaluated +13673,87276,36.849926,0.6591797,Cell membrane,keyword,88161,Transmembrane helix,0.64746094,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.698913220497869,0.36466453475901184,0.11120957022596367,0.43824701195219123,3.2790751193270506,6.0,13.0,3.787143492345805,0.0045224218529113114,N-side TM1 helix-start motif,True,assigned_and_evaluated +13674,85682,17.09554,0.73876953,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.73876953,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9258243727598566,0.29571159247263934,0.011076650420912717,0.44,26.69684256842988,1.0,17.0,6.015639188780143,0.24451580700257655,GTX helix-cap catalytic motif,True,assigned_and_evaluated +13675,36010,18.697475,0.9975586,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.94189453,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,15.0,18.0,424.6509971509972,5.339867690624812e-38,Alpha/beta-hydrolase cap/lid activation,True,assigned_too_few_test_positives +13676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal helices and IDR tails,False,no_term_above_threshold +13677,85649,43.846577,0.8828125,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8798828,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.802820053715309,0.5756637126140365,0.0101905183872397,0.6086956521739131,56.4901304073861,14.0,14.0,110.61410018552876,7.27210921345717e-29,Rossmann SAM-binding pocket,True,assigned_and_evaluated +13678,85664,25.747068,0.81152344,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.81152344,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,13.0,13.0,331.22777777777776,5.045422255836732e-33,Carbohydrate-active enzyme catalytic cores,True,assigned_too_few_test_positives +13679,87541,15.576398,0.64990234,Heme,keyword,87541,Heme,0.64990234,141,keywords,Heme,keyword:keywords:Heme,15.0,2257.0,0.7955396966993756,0.602658396101019,0.00664599025254763,0.6,90.67999999999999,17.0,18.0,95.76313303099016,5.0697552076669376e-33,P450 heme-ligating cysteine pocket,True,assigned_and_evaluated +13680,50338,22.682241,0.92285156,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.859375,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,13.0,0.0,1.0,Amphipathic cytosolic juxtamembrane helices,True,assigned_too_few_test_positives +13681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic TM helix and loop,False,no_term_above_threshold +13682,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary transporter cytoplasmic-loop activation,False,no_term_above_threshold +13683,82029,25.967016,0.99902344,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6201172,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS/SLC transmembrane-helix signature,True,assigned_too_few_test_positives +13684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix and juxtamembrane tail,False,no_term_above_threshold +13685,37430,16.55289,0.9995117,"Signal transduction response regulator, receiver domain",interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8457031,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,16.0,16.0,484.7235772357723,5.371460485985792e-43,REC domain phosphoacceptor segment,True,assigned_too_few_test_positives +13686,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HSF winged-helix DNA-binding,False,no_term_above_threshold +13687,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad conserved assembly scaffolds,False,no_term_above_threshold +13688,87697,19.47779,0.7192383,Knottin,keyword,87697,Knottin,0.7192383,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7364974220249243,0.09708908180357076,0.017279574656623838,,5.618719426427159,0.0,17.0,0.0,1.0,Hydrophobic extracellular capping motifs,True,assigned_and_evaluated +13689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated acidic S/T-rich scaffolds,False,no_term_above_threshold +13690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PilZ c-di-GMP binding site,False,no_term_above_threshold +13691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MtnB/APIP catalytic loop activation,False,no_term_above_threshold +13692,87882,19.176226,0.6333008,Palmitate,keyword,87882,Palmitate,0.6333008,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.49200355397601064,0.002658396101019052,0.002658396101019052,,1.0,11.0,20.0,36.63860335195531,2.8626007976676537e-15,Post-signal peptide N-termini,True,assigned_and_evaluated +13693,59229,23.776178,0.9692383,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9506836,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9525222840683507,0.41860395564238956,0.0101905183872397,0.391304347826087,41.07778816890753,13.0,13.0,106.27629233511585,1.263908364048505e-26,SAM-loop flanking beta-strands,True,assigned_and_evaluated +13694,63960,31.492628,0.8261719,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.8261719,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,Rossmann-like oxidoreductase lid scaffold,True,assigned_too_few_test_positives +13695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic interface patches,False,no_term_above_threshold +13696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic aromatic pocket/interface residues,False,no_term_above_threshold +13697,87276,30.678596,0.6455078,Cell membrane,keyword,88161,Transmembrane helix,0.6308594,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6894962522790196,0.3380635093379692,0.11120957022596367,0.42231075697211157,3.0398778508995874,5.0,19.0,2.1593362017761164,0.11810902030114691,Juxtamembrane helix–break–helix junctions,True,assigned_and_evaluated +13698,52270,16.636175,0.91552734,"WD40 repeat, conserved site",interpro,64085,WD40-repeat-containing domain superfamily,0.8984375,43,ip,IPR019775,interpro:ip:IPR019775,,,,,,,,0.0,18.0,0.0,1.0,Surface-exposed beta-alpha-beta loop,True,assigned_too_few_test_positives +13699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and pre-domains,False,no_term_above_threshold +13700,38890,19.322042,0.9921875,HNH nuclease,interpro,36409,"Zinc finger, CCCH-type",0.9760742,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,0.0,17.0,0.0,1.0,Extracellular cysteine disulfide loops,True,assigned_too_few_test_positives +13701,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic C-terminal binding surface,False,no_term_above_threshold +13702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory low-complexity IDRs,False,no_term_above_threshold +13703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-backbone recognition surface,False,no_term_above_threshold +13704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich mucin-like disordered segments,False,no_term_above_threshold +13705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metallopeptidase HExxH catalytic helix,False,no_term_above_threshold +13706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asp/Glu-rich catalytic microdomains,False,no_term_above_threshold +13707,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cohesin beta-sandwich repeats,False,no_term_above_threshold +13708,85762,34.073193,0.90722656,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.90234375,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,12.0,12.0,205.58965517241379,4.745472356953812e-28,Flavoprotein isoalloxazine lid helix,True,assigned_too_few_test_positives +13709,36115,23.73449,0.9609375,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9555664,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,7.0,12.0,216.018115942029,1.6964093133097665e-15,Cytosolic partner-binding segments,True,assigned_too_few_test_positives +13710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich surface interaction patches,False,no_term_above_threshold +13711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,W/G-enriched catalytic β-surface,False,no_term_above_threshold +13712,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF catalytic helix,False,no_term_above_threshold +13713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal coiled-coil stalks,False,no_term_above_threshold +13714,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal LLTP hydrophobic motif,False,no_term_above_threshold +13715,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-adjacent acceptor-binding loop,False,no_term_above_threshold +13716,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted CAZyme catalytic clefts,False,no_term_above_threshold +13717,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FERM/ERM membrane signaling modules,False,no_term_above_threshold +13718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like low-complexity IDRs,False,no_term_above_threshold +13719,37314,20.786915,0.9838867,"Helicase, C-terminal domain-like",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.9555664,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,10.0,10.0,317.1329787234043,2.3359544982732796e-25,Helicase C-terminal RecA-like subdomain,True,assigned_too_few_test_positives +13720,36104,20.683352,0.83251953,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.83251953,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Bacteroidetes C-terminal T9SS propeptides,True,assigned_too_few_test_positives +13721,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Respiratory Mo/W oxidoreductases,False,no_term_above_threshold +13722,33780,19.541662,0.81396484,"4 iron, 4 sulfur cluster binding",go_mf,64016,Thioredoxin-like superfamily,0.7363281,94,go,GO:0051539,go_mf:go:GO:0051539,,,,,,,,16.0,16.0,144.01207729468598,1.09191624420599e-34,N-terminal pre-triad rSAM scaffold,True,assigned_too_few_test_positives +13723,63960,15.70594,0.63720703,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.63720703,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,4.0,16.0,48.39366883116883,2.320435097883026e-06,NTP-binding anchor residue,True,assigned_too_few_test_positives +13724,37071,27.76582,0.99853516,Homeodomain,interpro,37071,Homeodomain,0.99853516,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,16.0,0.0,1.0,Short-helix hydrophobic micro-packing,True,assigned_too_few_test_positives +13725,36876,16.660122,1.0,Cytochrome P450,interpro,36876,Cytochrome P450,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,20.0,20.0,389.6797385620915,6.398876580228444e-51,Cytochrome P450 C-terminal cytosolic segment,True,assigned_and_evaluated +13726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal β–α–β loop–helix hairpins,False,no_term_above_threshold +13727,36535,20.711975,0.9453125,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.94384766,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9470182465509568,0.7665541771279476,0.004430660168365086,0.9,173.0112777777778,14.0,14.0,89.79066265060241,1.3182594076727404e-27,Kinase Y/F-APE aromatic anchor,True,assigned_and_evaluated +13728,36010,16.505405,0.99121094,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9453125,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,13.0,20.0,331.2277777777778,9.65493286079468e-31,Hydrolase N-terminal loop-to-beta strand,True,assigned_too_few_test_positives +13729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ectodomain head surface strands,False,no_term_above_threshold +13730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Topogenic N-terminal amphipathic helices,False,no_term_above_threshold +13731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Luminal-capped N-terminal TM1–TM2 hairpin,False,no_term_above_threshold +13732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor and TM hairpins,False,no_term_above_threshold +13733,82716,18.216124,0.984375,Laminin,gene3d,87413,Disulfide bond,0.6748047,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,15.0,15.0,289.42233009708735,4.383349844353145e-37,EGF-like repeat N-terminal entry,True,assigned_too_few_test_positives +13734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor domains and regulatory linkers,False,no_term_above_threshold +13735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-binding cap subdomain,False,no_term_above_threshold +13736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass TM boundary activation,False,no_term_above_threshold +13737,59218,26.771685,0.92871094,Metallo-dependent phosphatase-like,interpro,59218,Metallo-dependent phosphatase-like,0.92871094,36,ip,IPR029052,interpro:ip:IPR029052,,,,,,,,14.0,15.0,520.0585669781931,1.4362757837201359e-37,Diffuse activation in hydrolases,True,assigned_too_few_test_positives +13738,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta domain core scaffold,False,no_term_above_threshold +13739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long charged coiled-coil linkers,False,no_term_above_threshold +13740,87276,40.82011,0.6875,Cell membrane,keyword,88161,Transmembrane helix,0.66796875,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.8049149364655038,0.5298973970093431,0.11120957022596367,0.649402390438247,4.764854283068077,11.0,19.0,4.750539643907457,4.890440005771653e-06,Membrane interfacial helix-start motif,True,assigned_and_evaluated +13741,87697,27.821709,0.9038086,Knottin,keyword,87697,Knottin,0.9038086,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9410880673279232,0.12146831610909636,0.017279574656623838,,7.029589473287961,0.0,17.0,0.0,1.0,Acidic capping loop motif,True,assigned_and_evaluated +13742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thiolase-like acyl-channel lids,False,no_term_above_threshold +13743,87586,17.155243,0.7084961,Host membrane,keyword,88161,Transmembrane helix,0.6767578,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.786109082055028,0.12800803290827772,0.01639344262295082,,7.808490007404941,0.0,19.0,0.0,1.0,Transmembrane helix exit interface,True,assigned_and_evaluated +13744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal coiled-coil signaling helices,False,no_term_above_threshold +13745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic secondary structure signal,False,no_term_above_threshold +13746,49045,19.195726,0.9580078,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9082031,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,15.0,0.0,1.0,Beta-propeller and beta-solenoid repeats,True,assigned_too_few_test_positives +13747,59229,18.59889,0.90966797,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7788086,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9633237320462418,0.1454337287798315,0.0101905183872397,,14.271475037220855,0.0,17.0,0.0,1.0,Beta-strand N-cap loops,True,assigned_and_evaluated +13748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane alpha-helical cores,False,no_term_above_threshold +13749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM or catalytic detector,False,no_term_above_threshold +13750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered low-complexity linkers,False,no_term_above_threshold +13751,8138,20.338488,0.63720703,translation,go_bp,88022,Ribosomal protein,0.6040039,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.9200603152240907,0.43470624370275723,0.018165706690296855,0.8536585365853658,23.930048586271294,5.0,12.0,42.97938292964245,1.2455503370479346e-07,KH/S1/KOW RNA-binding surfaces and linkers,True,assigned_and_evaluated +13752,38317,27.723127,0.9604492,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9604492,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8252698412698414,0.03361103305674076,0.0031014621178555605,,10.837157372723414,0.0,10.0,0.0,1.0,Nucleotide-binding hinge loops,True,assigned_and_evaluated +13753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic pocket-lining helices,False,no_term_above_threshold +13754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-sequence alpha-helical interfaces,False,no_term_above_threshold +13755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine transesterase catalytic core,False,no_term_above_threshold +13756,87913,15.634374,0.82910156,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.82910156,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8672696006623781,0.06561577853569159,0.006202924235711121,,10.57820086821828,0.0,14.0,0.0,1.0,Conserved SPT16 N-terminal motif,True,assigned_and_evaluated +13757,87697,19.404087,0.86376953,Knottin,keyword,88058,Signal,0.6357422,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8200388430325309,0.04368118895752065,0.017279574656623838,,2.5279088071057463,0.0,20.0,0.0,1.0,Hydrophobic β-strand ectodomain cores,True,assigned_and_evaluated +13758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered K/R-rich polyanion-binding modules,False,no_term_above_threshold +13759,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered N-terminal regulatory/targeting tails,False,no_term_above_threshold +13760,64585,20.125988,0.9926758,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.98095703,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,20.0,0.0,1.0,Fe-S cluster ligation motifs,True,assigned_too_few_test_positives +13761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Exoribonuclease CSDs, ANL, ATPase half-channels",False,no_term_above_threshold +13762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane assembly anchors,False,no_term_above_threshold +13763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity linkers,False,no_term_above_threshold +13764,87239,15.881602,0.74560547,CF(1),keyword,87239,CF(1),0.74560547,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.997228430934287,0.5842558932084103,0.008861320336730172,1.0,65.93327754856911,0.0,15.0,0.0,1.0,Polynucleotide kinase catalytic core,True,assigned_and_evaluated +13765,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane low-complexity tails,False,no_term_above_threshold +13766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adhesin extracellular beta-strand motifs,False,no_term_above_threshold +13767,58239,26.678656,0.8359375,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8359375,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8821380243572395,0.3725272459448519,0.017722640673460344,0.325,21.01984985243827,12.0,12.0,35.851473241130485,5.407409530965992e-19,Non-catalytic coupling helices,True,assigned_and_evaluated +13768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic kinase activation segment,False,no_term_above_threshold +13769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +13770,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate/nucleotide-binding helix-loop motifs,False,no_term_above_threshold +13771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta barrel extracytoplasmic features,False,no_term_above_threshold +13772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CCT QREAAL; signal peptide core,False,no_term_above_threshold +13773,64620,15.807042,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.78027344,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,14.0,14.0,324.0271739130435,2.279682820657023e-35,ATP-lid helix-loop hinge,True,assigned_too_few_test_positives +13774,87149,23.633438,0.70947266,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.70947266,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7766134717682496,0.11284466958526429,0.012405848471422242,,9.096086401926483,0.0,20.0,0.0,1.0,Membrane-binding low-complexity segments,True,assigned_and_evaluated +13775,45289,20.531578,0.9970703,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.9970703,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,17.0,18.0,853.1624579124579,7.155354729943785e-49,Conserved glycine-rich beta-strand motifs,True,assigned_too_few_test_positives +13776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease transmembrane helices,False,no_term_above_threshold +13777,28622,20.409014,0.8798828,transposase activity,go_mf,88164,Transposition,0.8520508,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.8984014209591474,0.54377639935017,0.002215330084182543,0.8,245.46066666666675,3.0,16.0,214.9795673076923,6.75799162928635e-07,Polybasic IDRs and loop motifs,True,assigned_and_evaluated +13778,36876,16.28902,0.9995117,Cytochrome P450,interpro,64154,Cytochrome P450 superfamily,0.9995117,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,16.0,16.0,389.6797385620915,1.6482263221307779e-41,P450 proximal C-terminal meander,True,assigned_and_evaluated +13779,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Packing signal-anchor transmembrane helices,False,no_term_above_threshold +13780,85664,21.98989,0.98046875,Glycogen Phosphorylase B;,gene3d,85656,alpha/beta hydrolase,0.8022461,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,GT-B TPxxAx donor motif,True,assigned_too_few_test_positives +13781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIR/SEFIR BB-loop hinge,False,no_term_above_threshold +13782,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse GH catalytic-domain activation,False,no_term_above_threshold +13783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Gly-rich interfacial loops,False,no_term_above_threshold +13784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic/Trp-rich acceptor-track loop,False,no_term_above_threshold +13785,88058,73.72968,0.8129883,Signal,keyword,88058,Signal,0.8129883,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8066560001514771,0.5266373136554824,0.09127159946832078,0.6553398058252428,5.770002023885552,18.0,20.0,6.484459214501511,1.1690409353618823e-13,Signal peptide cleavage spacer,True,assigned_and_evaluated +13786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disulfide-rich extracellular flexible loops,False,no_term_above_threshold +13787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase H-like GSGYPDP motif,False,no_term_above_threshold +13788,25014,16.86861,0.7861328,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.6845703,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.6361321846470361,0.07383751754483812,0.015507310589277802,,4.761465059962847,5.0,18.0,10.235716247768165,0.0001701104288579207,Lumenal transmembrane helix caps,True,assigned_and_evaluated +13789,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP pre-TPase pedestal,False,no_term_above_threshold +13790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ub/Ubl papain-like cysteine proteases,False,no_term_above_threshold +13791,39971,28.466576,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98583984,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,16.0,18.0,588.8493827160494,4.036993795200243e-43,Binuclear metallohydrolase catalytic core,True,assigned_too_few_test_positives +13792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metalloenzyme C-terminal cap helix,False,no_term_above_threshold +13793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta-strand patches,False,no_term_above_threshold +13794,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich mixed-charge IDRs,False,no_term_above_threshold +13795,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Ser-rich active-site loops,False,no_term_above_threshold +13796,15821,16.153448,0.68896484,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.68896484,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,17.0,0.0,1.0,GRAM/PH lipid-sensing regions,True,assigned_too_few_test_positives +13797,38890,21.201874,0.97802734,HNH nuclease,interpro,38890,HNH nuclease,0.97802734,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,2.0,14.0,185.1583850931677,9.683749551747413e-05,ββα-Me/HNH nuclease catalytic core,True,assigned_too_few_test_positives +13798,87697,16.061169,0.7988281,Knottin,keyword,87413,Disulfide bond,0.65527344,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.818824998265936,0.04424091035817173,0.017279574656623838,,2.560300889189579,0.0,13.0,0.0,1.0,Beta-strand residue detector,True,assigned_and_evaluated +13799,45714,16.671396,0.86083984,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.86083984,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,13.0,0.0,1.0,Sensor-effector coupling helix,True,assigned_too_few_test_positives +13800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved anion binding microsites,False,no_term_above_threshold +13801,87149,19.28961,0.69091797,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.69091797,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7128116387874126,0.039405389292708294,0.012405848471422242,,3.176355844058665,0.0,20.0,0.0,1.0,Alpha-helical residue detector,True,assigned_and_evaluated +13802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular periplasmic loop activation,False,no_term_above_threshold +13803,87697,22.018326,0.9086914,Knottin,keyword,87413,Disulfide bond,0.6689453,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9449203486624587,0.13051332428460471,0.017279574656623838,,7.553040331034688,0.0,12.0,0.0,1.0,Short exposed binding loops,True,assigned_and_evaluated +13804,59224,16.10181,0.88964844,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8413086,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9180952380952381,0.021362600218305158,0.0031014621178555605,,6.88791267038782,0.0,17.0,0.0,1.0,Catalytic beta-strand scaffold,True,assigned_and_evaluated +13805,59229,17.585972,0.6254883,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6254883,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7284652212837179,0.11968244004415214,0.0101905183872397,0.043478260869565216,11.744489877376147,14.0,17.0,87.52165251127188,7.507036520153059e-26,Noncatalytic N-terminal accessory interfaces,True,assigned_and_evaluated +13806,86130,24.997496,0.9638672,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9580078,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.8898095238095239,0.030370419673110303,0.0031014621178555605,,9.792291028887137,0.0,15.0,0.0,1.0,Small-residue TM helix interfaces,True,assigned_and_evaluated +13807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Microtubule-binding phospho-rich IDRs,False,no_term_above_threshold +13808,37894,18.42421,0.9765625,Short-chain dehydrogenase/reductase SDR,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9291992,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,13.0,0.0,1.0,Adenine-binding glycine-rich loops,True,assigned_too_few_test_positives +13809,46078,17.698761,0.8886719,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.88671875,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,16.0,19.0,110.1034164358264,4.040725274098586e-31,HEAT/ARM Ran-binding acidic motif,True,assigned_too_few_test_positives +13810,47529,20.202904,0.8208008,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8208008,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7927404060687194,0.2127642624568854,0.007089056269384138,0.25,30.013058772824397,6.0,19.0,24.419823878763054,2.1182407366418683e-07,Beta-rich interaction domains,True,assigned_and_evaluated +13811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal soluble segment detector,False,no_term_above_threshold +13812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxidoreductase active-site helix,False,no_term_above_threshold +13813,37020,18.04002,0.9916992,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9785156,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,14.0,16.0,714.6352739726027,4.1365210065363404e-39,ALG mannosyltransferase catalytic loop,True,assigned_too_few_test_positives +13814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidohydrolase TIM barrel loops,False,no_term_above_threshold +13815,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic aromatic peptidoglycan-binding cleft,False,no_term_above_threshold +13816,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphoryl transfer loop-helix scaffolds,False,no_term_above_threshold +13817,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged N-terminal helical stalks,False,no_term_above_threshold +13818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal domain start signal,False,no_term_above_threshold +13819,64058,22.92813,0.68847656,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6748047,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6041653397872746,0.21915944047091587,0.006202924235711121,0.21428571428571427,35.33163265306122,9.0,14.0,73.28448511335701,1.3082164979288461e-15,Rossmann interstrand loop hotspot,True,assigned_and_evaluated +13820,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid enzyme cores and dsRNA,False,no_term_above_threshold +13821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged boundary interaction patches,False,no_term_above_threshold +13822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature secreted soluble domains,False,no_term_above_threshold +13823,37341,17.012833,0.9379883,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.93359375,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9800531473177212,0.226707144427957,0.011962782454585734,,18.951037961996256,0.0,14.0,0.0,1.0,Glycine loop to strand junctions,True,assigned_and_evaluated +13824,38317,16.537296,0.8769531,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8769531,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6797460317460318,0.03536069944149569,0.0031014621178555605,,11.401299805636539,0.0,15.0,0.0,1.0,C-terminal cap/appendage domains,True,assigned_and_evaluated +13825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thr-Gly strand-loop micro-motif,False,no_term_above_threshold +13826,86137,18.625128,0.85058594,Helix-loop-helix DNA-binding domain,gene3d,86137,Helix-loop-helix DNA-binding domain,0.85058594,40,gene3d,4.10.280.10,gene3d:gene3d:4.10.280.10,,,,,,,,0.0,20.0,0.0,1.0,Coiled-coil hinge linker,True,assigned_too_few_test_positives +13827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VRR-NUC/PD-(D/E)XK catalytic core,False,no_term_above_threshold +13828,64620,21.6603,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.98339844,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,GHKL ATPase N-cap motif,True,assigned_too_few_test_positives +13829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZyme polysaccharide binding patch,False,no_term_above_threshold +13830,30856,15.832108,0.77978516,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.6777344,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.7093250444049735,0.005665128718789466,0.002215330084182543,,2.557239103661565,0.0,17.0,0.0,1.0,Multi-pass hydrophobic TM helices,True,assigned_and_evaluated +13831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-lined glycan-binding groove,False,no_term_above_threshold +13832,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic phosphate-binding active site,False,no_term_above_threshold +13833,48767,23.491285,0.99902344,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.99902344,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,7.0,0.0,1.0,Peripheral strand-helix connectors,True,assigned_too_few_test_positives +13834,36091,22.047703,0.9604492,GNAT domain,interpro,85712,3.40.630.30,0.9042969,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,14.0,0.0,1.0,Histidine kinase CA beta-strands,True,assigned_too_few_test_positives +13835,46082,18.402464,0.83691406,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.83691406,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.8506666666666668,0.17995412286636975,0.0031014621178555605,,58.02235075848522,10.0,15.0,100.62616033755275,1.062689637692936e-18,Anionic N-terminal interaction patches,True,assigned_and_evaluated +13836,37894,17.70654,0.9975586,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.9682617,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,13.0,709.7738095238095,2.0554498274794366e-37,Rossmann β1–α1 NAD(P)-binding motif,True,assigned_too_few_test_positives +13837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,START domain capping helix,False,no_term_above_threshold +13838,69819,21.197533,0.8779297,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8544922,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,14.0,17.0,345.77216238608116,3.203283419910786e-34,ASKHA β–strand–helix motif,True,assigned_too_few_test_positives +13839,36668,18.64752,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9736328,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,13.0,13.0,532.3303571428571,9.561000563003835e-36,ANL A8–A10 catalytic loop,True,assigned_too_few_test_positives +13840,85649,26.3973,0.70996094,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7060547,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.7567727998131641,0.3760953823467931,0.0101905183872397,0.34782608695652173,36.90640338942226,14.0,15.0,103.23982683982683,1.0300586552902711e-27,Aromatic/basic SAM-binding motif,True,assigned_and_evaluated +13841,64058,22.480347,0.9604492,NAD(P)-binding domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.80126953,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9852238710910134,0.3684250862410623,0.006202924235711121,0.14285714285714285,59.39538711757697,3.0,16.0,21.374641491395792,0.000617012579665512,Rossmann adenylate-binding beta-strand starts,True,assigned_and_evaluated +13842,37894,17.038008,0.80029297,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.69091797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,7.0,9.0,552.0462962962963,7.712822084981217e-19,Rossmann-fold NAD(P)H oxidoreductase,True,assigned_too_few_test_positives +13843,85649,17.840605,0.67041016,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.67041016,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6012416799657467,0.051340518624909216,0.0101905183872397,,5.03806741462696,13.0,16.0,89.8739564007421,3.760650423786563e-24,Adenine cofactor loop-helix motif,True,assigned_and_evaluated +13844,38317,20.56787,0.79785156,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.79785156,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6397142857142856,0.17681850468735713,0.0031014621178555605,0.14285714285714285,57.01133786848072,0.0,11.0,0.0,1.0,Plant receptor ectodomain loops,True,assigned_and_evaluated +13845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleoporin FG-repeat IDRs,False,no_term_above_threshold +13846,85364,17.582209,0.7675781,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7675781,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,3.0,18.0,50.186026936026934,5.244922657405042e-05,SBP mature N-terminus hinge,True,assigned_too_few_test_positives +13847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic polar coil boundary marker,False,no_term_above_threshold +13848,84612,15.982022,0.82714844,"Knottin, scorpion toxin-like",gene3d,84612,"Knottin, scorpion toxin-like",0.82714844,34,gene3d,3.30.30.10,gene3d:gene3d:3.30.30.10,,,,,,,,0.0,17.0,0.0,1.0,WSC and endostatin ectodomains,True,assigned_too_few_test_positives +13849,87913,15.6279125,0.7832031,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.7832031,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8203936055028342,0.6450724729413254,0.006202924235711121,0.6428571428571429,103.99489795918367,11.0,15.0,352.5973118279569,8.743265032722078e-27,Conserved KS-AT linker,True,assigned_and_evaluated +13850,42054,15.932922,0.97802734,Radical SAM,interpro,42054,Radical SAM,0.97802734,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,18.0,18.0,677.5113636363636,2.134840317179899e-50,Cobalamin-dependent radical SAM methyltransferase C-terminus,True,assigned_too_few_test_positives +13851,87326,30.571575,0.6357422,Coiled coil,keyword,87326,Coiled coil,0.6357422,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6312347112235168,0.24146751494297936,0.03943287549844927,0.23595505617977527,6.123507654228139,15.0,15.0,12.607528018608585,7.347884562134567e-17,Eukaryotic long coiled-coil scaffolds,True,assigned_and_evaluated +13852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fold IV PLP catalytic core,False,no_term_above_threshold +13853,38317,15.588834,0.8730469,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8730469,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6486031746031746,0.008673808468890437,0.0031014621178555605,,2.796683673469388,0.0,14.0,0.0,1.0,Metal-chelating catalytic cores,True,assigned_and_evaluated +13854,87522,21.668484,0.61572266,Glycoprotein,keyword,88161,Transmembrane helix,0.6044922,1135,keywords,Glycoprotein,keyword:keywords:Glycoprotein,89.0,2257.0,0.6888423027488701,0.21367453369530698,0.03943287549844927,0.15730337078651685,5.418690141014695,11.0,15.0,7.669192539320587,1.1604805401443987e-08,Secretory carbohydrate enzyme N-termini,True,assigned_and_evaluated +13855,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered cytosolic linkers and tails,False,no_term_above_threshold +13856,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich disordered interaction hubs,False,no_term_above_threshold +13857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed helical faces,False,no_term_above_threshold +13858,36272,15.832801,0.92285156,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.92285156,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,16.0,0.0,1.0,Distal non-catalytic helical subdomain,True,assigned_too_few_test_positives +13859,64148,20.221922,0.67333984,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.6699219,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.7268472790555476,0.1641873332866155,0.008418254319893664,0.10526315789473684,19.503726906731117,4.0,16.0,22.246641791044777,4.784457211057719e-05,OmpR/PhoB recognition helix,True,assigned_and_evaluated +13860,36776,15.658927,0.9819336,SANT/Myb domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.95166016,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9617577373019399,0.03757101282164131,0.002658396101019052,,14.132962656407406,0.0,17.0,0.0,1.0,HTH recognition helix residues,True,assigned_and_evaluated +13861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensory helix N-cap sensors,False,no_term_above_threshold +13862,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-catalytic N-terminal accessory regions,False,no_term_above_threshold +13863,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic acidic-His metal neighborhood,False,no_term_above_threshold +13864,27013,18.07666,0.7373047,side of membrane,go_cc,87489,GPI-anchor,0.7368164,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.7346734784540204,0.0383553418413592,0.002658396101019052,,14.428001089324617,0.0,19.0,0.0,1.0,Thr-biased Ser/Thr mucin-like linkers,True,assigned_and_evaluated +13865,88161,20.471506,0.6069336,Transmembrane helix,keyword,88161,Transmembrane helix,0.6069336,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6186972161401314,0.2634386440209661,0.1847585290208241,,1.425853763921632,13.0,20.0,3.5278698224852074,1.103633606659121e-05,Signal-anchor helices and low-complexity IDRs,True,assigned_and_evaluated +13866,49116,22.991917,0.8574219,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8574219,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8976465364120783,0.6893319549057254,0.002215330084182543,0.6,311.1644444444445,17.0,17.0,87.03795620437957,3.968138690208192e-33,Alpha-solenoid helical repeat scaffolds,True,assigned_and_evaluated +13867,50338,17.793055,0.82470703,"GPCR, rhodopsin-like, 7TM",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6269531,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,8.0,0.0,1.0,ABC NBD helical micro-motif,True,assigned_too_few_test_positives +13868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site pocket helices/loops,False,no_term_above_threshold +13869,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal edge segments,False,no_term_above_threshold +13870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal disordered acidic tails,False,no_term_above_threshold +13871,49061,26.00162,0.9980469,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9980469,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9999759661603538,0.9974929627023222,0.012405848471422242,1.0,80.40505774354077,19.0,19.0,98.87396351575455,6.315402421230918e-38,Beta-propeller loop peaks,True,assigned_and_evaluated +13872,85649,39.592552,0.97998047,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97753906,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.889027285819937,0.74330739468042,0.0101905183872397,0.782608695652174,72.94107781711773,17.0,17.0,110.61410018552876,7.110790058883305e-35,Conserved SAM MTase core segment,True,assigned_and_evaluated +13873,37312,15.81708,0.99316406,"DNA-binding HTH domain, TetR-type",interpro,85664,Glycogen Phosphorylase B;,0.8339844,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,5.0,0.0,1.0,ABC ATPase coupling linker,True,assigned_too_few_test_positives +13874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic extramembrane domains,False,no_term_above_threshold +13875,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M4 P-domain phosphorylation loop,False,no_term_above_threshold +13876,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved noncatalytic polar residues,False,no_term_above_threshold +13877,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM1-luminal loop and IDR activation,False,no_term_above_threshold +13878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-gating lid/hinge subdomain,False,no_term_above_threshold +13879,59224,43.21499,0.921875,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.921875,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9998730158730159,0.9682539682539681,0.0031014621178555605,1.0,312.1927437641723,18.0,18.0,137.37557603686636,1.6332112516921354e-38,Serine hydrolase active-site lids,True,assigned_and_evaluated +13880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich low-complexity repeats,False,no_term_above_threshold +13881,88161,32.9817,0.6748047,Transmembrane helix,keyword,88161,Transmembrane helix,0.6748047,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.741372119695548,0.5170750931553728,0.1847585290208241,0.45323741007194246,2.798653441850543,9.0,10.0,4.884742831133364,3.879392548464913e-06,Membrane helix and signal-peptide starts,True,assigned_and_evaluated +13882,88160,16.596897,0.88671875,Transmembrane beta strand,keyword,25167,cell outer membrane,0.7426758,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,19.0,20.0,274.951213592233,3.4065747523159345e-45,Outer-membrane beta-barrel strands,True,assigned_too_few_test_positives +13883,49045,19.263485,0.99072266,Kelch-type beta propeller,interpro,49045,Kelch-type beta propeller,0.99072266,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,0.0,16.0,0.0,1.0,Asp-box beta-propeller loops,True,assigned_too_few_test_positives +13884,55053,21.732195,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,9.0,9.0,552.0462962962963,4.519360820405452e-25,Catalytic loop-transition hotspots,True,assigned_too_few_test_positives +13885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TBDT mid-barrel loop/strand belt,False,no_term_above_threshold +13886,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metzincin scaffold and propeptide recognizer,False,no_term_above_threshold +13887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal edge beta-strand patch,False,no_term_above_threshold +13888,31094,17.203411,0.99853516,phosphopantetheine binding,go_mf,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9981308411214953,0.6379334554334555,0.004430660168365086,1.0,143.9815808913309,12.0,13.0,655.1758241758242,1.6334101989150713e-33,Condensation domain regional activation,True,assigned_and_evaluated +13889,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic sulfatase motif hotspots,False,no_term_above_threshold +13890,64016,36.6862,0.9926758,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.9921875,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9977777777777779,0.4542647828362114,0.0031014621178555605,0.5714285714285714,146.46794498018988,13.0,16.0,180.08201672862452,4.519588074814736e-28,Thioredoxin-like redox active-site signature,True,assigned_and_evaluated +13891,6543,15.588473,0.84716797,NADH:ubiquinone reductase (H+-translocating),ec,88161,Transmembrane helix,0.64697266,41,ec,7.1.1.2,ec:ec:7.1.1.2,,,,,,,,5.0,11.0,307.9597107438016,6.233234191674785e-12,Alpha-helical transmembrane segments,True,assigned_too_few_test_positives +13892,8305,16.884314,0.77001953,fatty acid biosynthetic process,go_bp,8305,fatty acid biosynthetic process,0.77001953,31,go,GO:0006633,go_bp:go:GO:0006633,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,281.2311320754717,1.2830750204188693e-41,Condensing-enzyme C-terminal gating segment,True,assigned_and_evaluated +13893,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short ordered extracellular loops,False,no_term_above_threshold +13894,43624,30.01959,0.95703125,Homedomain-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9511719,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.9761825078090138,0.15183830799372453,0.007089056269384138,,21.418691321364765,0.0,18.0,0.0,1.0,HTH/wHTH recognition helices,True,assigned_and_evaluated +13895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding loop,False,no_term_above_threshold +13896,87326,18.085983,0.6328125,Coiled coil,keyword,87326,Coiled coil,0.6328125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7414305112152244,0.16981740089961866,0.03943287549844927,0.033707865168539325,4.306492964386959,9.0,17.0,6.674573656910428,3.1772786071036616e-06,Coiled-coil tethering stalks,True,assigned_and_evaluated +13897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich IDR detector,False,no_term_above_threshold +13898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-signal N-terminal prodomains,False,no_term_above_threshold +13899,52910,15.842321,0.9477539,"Polyketide synthase, phosphopantetheine-binding domain",interpro,52910,"Polyketide synthase, phosphopantetheine-binding domain",0.9477539,30,ip,IPR020806,interpro:ip:IPR020806,10.0,2257.0,0.7285491766800178,0.02520074428522311,0.004430660168365086,,5.687807985174857,0.0,12.0,0.0,1.0,Early phosphate-binding beta-alpha loop,True,assigned_and_evaluated +13900,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-type ATPase ATP-binding core,False,no_term_above_threshold +13901,37894,28.689857,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7631836,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,16.0,16.0,709.7738095238095,1.3714649252219745e-45,SDR YXXXK catalytic loop,True,assigned_too_few_test_positives +13902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta cofactor-binding scaffold,False,no_term_above_threshold +13903,88058,72.152534,0.9111328,Signal,keyword,88058,Signal,0.9111328,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9165443804348341,0.6044631583486927,0.09127159946832078,0.7669902912621359,6.6226861572475695,18.0,19.0,6.825746541580537,1.3747497370901924e-14,Sec-type signal peptide h-region,True,assigned_and_evaluated +13904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted peptide prepro regions,False,no_term_above_threshold +13905,42974,16.091509,0.9770508,"Serine/threonine-protein kinase, active site",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9301758,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9956825396825397,0.5933828076685219,0.0031014621178555605,0.8571428571428571,191.32357098683627,1.0,17.0,7.828387605042017,0.19336219987881278,PAS/PAC beta-strand core,True,assigned_and_evaluated +13906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix packing motifs,False,no_term_above_threshold +13907,86130,18.229424,0.91308594,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,64594,Zn(2)-C6 fungal-type DNA-binding domain superfamily,0.9082031,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9662857142857143,0.047136850583691686,0.0031014621178555605,,15.198267395341734,0.0,15.0,0.0,1.0,Beta-strand N-cap residues,True,assigned_and_evaluated +13908,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal interaction regions,False,no_term_above_threshold +13909,38317,17.130295,0.8754883,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8754883,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.840952380952381,0.058493313662305334,0.0031014621178555605,,18.859915562260447,0.0,17.0,0.0,1.0,Whole-chain ASTE1/FAM120/CHMP7 activation,True,assigned_and_evaluated +13910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane C-terminal regulatory domains,False,no_term_above_threshold +13911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anionic ligand-binding patches,False,no_term_above_threshold +13912,36776,19.039188,0.9892578,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.97802734,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9783059381015845,0.06458440170329605,0.002658396101019052,,24.29449910738986,0.0,17.0,0.0,1.0,DNA binding recognition helices,True,assigned_and_evaluated +13913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CD38 catalytic disulfide module,False,no_term_above_threshold +13914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil scaffolds,False,no_term_above_threshold +13915,47529,27.03449,0.9580078,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9580078,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9902387327086123,0.3335360382031853,0.007089056269384138,0.1875,47.04942738903682,6.0,14.0,33.14118954974986,2.5276110948553164e-08,Asx–Ser/Thr strand-capping β-turns,True,assigned_and_evaluated +13916,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-to-helix N-cap motif,False,no_term_above_threshold +13917,87326,35.169056,0.6972656,Coiled coil,keyword,87326,Coiled coil,0.6972656,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6987489116464198,0.2593316455020175,0.03943287549844927,0.2247191011235955,6.576533976382623,17.0,19.0,11.28041980612347,6.733872062658451e-17,Coiled-coil heptad register,True,assigned_and_evaluated +13918,49116,24.420485,0.96777344,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.96777344,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9979573712255773,0.4947186147186147,0.002215330084182543,0.2,223.3159826839827,19.0,19.0,87.03795620437957,6.605101239071875e-37,Periodic ARM/HEAT helical patches,True,assigned_and_evaluated +13919,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Iron-associated oxidoreductase signature,False,no_term_above_threshold +13920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface hydrophobic segments,False,no_term_above_threshold +13921,88164,17.03517,0.7324219,Transposition,keyword,88164,Transposition,0.7324219,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.4953374777975133,0.002215330084182543,0.002215330084182543,,1.0,2.0,19.0,76.53530166880616,0.0005634924528464306,Charged helix-exit loops,True,assigned_and_evaluated +13922,50806,17.770498,0.74121094,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.74121094,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,10.0,0.0,1.0,LMW-PTP DPYY catalytic loop,True,assigned_too_few_test_positives +13923,63960,21.932243,0.71435547,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.71435547,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,FAD/NAD(P)H Rossmann oxidoreductases,True,assigned_too_few_test_positives +13924,64058,16.855856,0.65185547,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.65185547,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8534488249156105,0.5407461869698402,0.006202924235711121,0.5,87.17601028506638,15.0,15.0,113.99808795411089,4.589611073054062e-31,Oxidoreductase N-terminal cofactor loop,True,assigned_and_evaluated +13925,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich noncatalytic accessory domains,False,no_term_above_threshold +13926,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial extracellular region activation,False,no_term_above_threshold +13927,27735,17.072788,0.6982422,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.6982422,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.684515394959142,0.19586770283649224,0.011519716437749225,0.19230769230769232,17.00282328084473,12.0,20.0,27.141578148710167,3.2541897466837145e-15,Fungal TF disordered activation domains,True,assigned_and_evaluated +13928,72011,16.701422,0.97558594,"AMP-binding enzyme, C-terminal domain superfamily",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.8857422,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,DHp coiled-coil signaling helices,True,assigned_too_few_test_positives +13929,63960,30.473286,0.9633789,FAD/NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.89160156,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,18.0,18.0,193.57467532467533,4.1657852190163465e-41,N-terminal FAD Rossmann motif,True,assigned_too_few_test_positives +13930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Argonaute/PIWI PIWI-domain signature,False,no_term_above_threshold +13931,87276,28.30431,0.61816406,Cell membrane,keyword,88161,Transmembrane helix,0.6098633,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6825211616147574,0.3021333594590059,0.11120957022596367,0.40239043824701193,2.7167927980038895,4.0,18.0,1.8234394592776095,0.2670540040780674,Hydrophobic transmembrane helix cores,True,assigned_and_evaluated +13932,37690,18.737114,0.7480469,Ankyrin repeat,interpro,82608,Ankyrin repeat-containing domain,0.73779297,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.8901904761904762,0.030372783656198617,0.0031014621178555605,,9.793053244577182,0.0,18.0,0.0,1.0,Helix–strand junction motif,True,assigned_and_evaluated +13933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible small-residue catalytic loops,False,no_term_above_threshold +13934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal/IDR bias with Gly/Lys/Ser/Thr-rich loops,False,no_term_above_threshold +13935,45290,37.156994,0.9770508,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9770508,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9610242698477992,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,14.0,17.0,60.46754563894523,1.282211861994168e-23,Kinase N-lobe beta-sheet core,True,assigned_and_evaluated +13936,64475,19.876175,0.99902344,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.96777344,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,1.0,0.9999999999999998,0.0057598582188746125,1.0,173.61538461538458,15.0,15.0,532.3303571428571,4.765377825901055e-41,Phosphopantetheine serine helix motif,True,assigned_and_evaluated +13937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytosolic amphipathic α-helices,False,no_term_above_threshold +13938,64058,17.9502,0.64453125,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.64453125,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7834214381249601,0.3134039064263613,0.006202924235711121,0.42857142857142855,50.52518691459267,15.0,15.0,113.99808795411089,4.589611073054062e-31,Oxidoreductase C-terminal helical cap,True,assigned_and_evaluated +13939,85364,25.656141,0.99658203,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.99658203,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,18.0,301.1161616161616,2.0260096530472245e-44,Helix-start ligand-binding hotspots,True,assigned_too_few_test_positives +13940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interfacial catalytic modules,False,no_term_above_threshold +13941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short interfacial amphipathic helices,False,no_term_above_threshold +13942,55053,20.036781,0.921875,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.921875,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,18.0,0.0,1.0,Non-transmembrane beta-sheet domains,True,assigned_too_few_test_positives +13943,88160,17.991137,0.8149414,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6772461,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,18.0,19.0,274.18957588145116,5.9579855910490204e-43,Porin loop and eyelet regions,True,assigned_too_few_test_positives +13944,87326,27.514399,0.6489258,Coiled coil,keyword,87326,Coiled coil,0.6489258,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6347822256312451,0.12405602422112055,0.03943287549844927,,3.1460050187311137,11.0,19.0,7.299095168668129,6.365830407590611e-08,Long oligomeric coiled-coil stalks,True,assigned_and_evaluated +13945,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Macromolecular complex scaffold subunits,False,no_term_above_threshold +13946,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal accessory domains,False,no_term_above_threshold +13947,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic-flanked terminal TM helix,False,no_term_above_threshold +13948,43643,16.210331,0.96191406,Phosphopantetheine binding ACP domain,interpro,43643,Phosphopantetheine binding ACP domain,0.96191406,47,ip,IPR009081,interpro:ip:IPR009081,13.0,2257.0,0.9910530645824764,0.3297658981796834,0.0057598582188746125,0.7692307692307693,57.25243324550349,0.0,15.0,0.0,1.0,Histidine kinase DHp coiled-coils,True,assigned_and_evaluated +13949,63831,24.806482,0.7290039,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.7290039,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.6602250851473419,0.034510359305441274,0.002658396101019052,,12.981646825396824,0.0,16.0,0.0,1.0,Gly/Ser-rich nucleotidyltransferase active-site loop,True,assigned_and_evaluated +13950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +13951,37071,17.29308,0.97558594,Homeodomain,interpro,38317,Pentatricopeptide repeat,0.97314453,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,14.0,0.0,1.0,Amphipathic interface helices,True,assigned_too_few_test_positives +13952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IDHK/P pre-ATP regulatory motif,False,no_term_above_threshold +13953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HlyD-family MFP periplasmic domains,False,no_term_above_threshold +13954,37446,19.918676,0.98339844,F-box domain,interpro,37446,F-box domain,0.98339844,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.986,0.11117386348478786,0.0031014621178555605,,35.845629983595174,0.0,16.0,0.0,1.0,Acidic-basic helical anchor motifs,True,assigned_and_evaluated +13955,36115,18.280958,0.9238281,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9223633,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,15.0,0.0,1.0,PRY/SPRY immune recognition hotspot,True,assigned_too_few_test_positives +13956,87326,36.79022,0.72753906,Coiled coil,keyword,87326,Coiled coil,0.72753906,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7417984783780422,0.21813894356278776,0.03943287549844927,0.20224719101123595,5.531905568777663,10.0,18.0,7.004182232560326,4.5957150021109826e-07,Amphipathic coiled-coil helices,True,assigned_and_evaluated +13957,36354,18.120653,0.9555664,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9555664,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,15.0,0.0,1.0,TPR/alpha-solenoid carboxylate clamps,True,assigned_too_few_test_positives +13958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface polar capping segments,False,no_term_above_threshold +13959,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane interface anchoring helices,False,no_term_above_threshold +13960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical disordered linkers,False,no_term_above_threshold +13961,64155,22.075212,0.92333984,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.9169922,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,1.0,20.0,13.865348837209302,0.11389251897461584,Unannotated transposase-derived regions,True,assigned_too_few_test_positives +13962,85672,20.381777,0.77734375,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7739258,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8624868677772776,0.10997719439670692,0.01595037660611431,,6.894959104260209,6.0,10.0,24.008456375838925,9.207917103259817e-08,Conserved LPxPS helix motif,True,assigned_and_evaluated +13963,37894,22.996988,0.8798828,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.69970703,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,5.0,17.0,208.75700280112045,6.398986978774497e-11,Fungal PKS KR/PT hotspots,True,assigned_too_few_test_positives +13964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic alpha-helices,False,no_term_above_threshold +13965,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UvrD-like helicase C-terminal subdomain,False,no_term_above_threshold +13966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coil scaffolds,False,no_term_above_threshold +13967,80926,20.810839,0.67871094,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.66308594,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.8386295077471548,0.33684337196454084,0.0057598582188746125,0.46153846153846156,58.48119157876682,8.0,18.0,42.39715555555555,1.2049777110623043e-11,Short helical contact element,True,assigned_and_evaluated +13968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered extramembrane tails and loops,False,no_term_above_threshold +13969,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-start N-cap residues,False,no_term_above_threshold +13970,64016,26.783241,0.9433594,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.9433594,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9159999999999999,0.5923742829480534,0.0031014621178555605,0.5714285714285714,190.99839380196522,12.0,14.0,189.97663303239509,1.5995129547300222e-26,Pre-motif redox positioning segment,True,assigned_and_evaluated +13971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-acidic starch-biased glycan-binding surfaces,False,no_term_above_threshold +13972,36010,18.27666,0.9873047,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97753906,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,2.0,16.0,63.69764957264958,0.0008008751849762338,Conserved EYFEE acidic aromatic motif,True,assigned_too_few_test_positives +13973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical transmembrane segments,False,no_term_above_threshold +13974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-transducing helical linkers,False,no_term_above_threshold +13975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-interacting beta-strand domains,False,no_term_above_threshold +13976,38873,17.444553,0.78466797,AAA+ ATPase domain,interpro,38873,AAA+ ATPase domain,0.78466797,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8965364120781528,0.35832185389562443,0.002215330084182543,0.2,161.74648484848487,6.0,6.0,171.32471264367817,8.628714627566988e-14,AAA+ ATPase mechanoenzymes,True,assigned_and_evaluated +13977,49236,21.817638,0.9995117,C-type lectin fold,interpro,49236,C-type lectin fold,0.9995117,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,16.0,17.0,510.12620320855615,1.225281491287518e-42,CTLD beta-sheet cores,True,assigned_and_evaluated +13978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted flexible propeptide loops,False,no_term_above_threshold +13979,49121,17.7716,0.8876953,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.8876953,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,16.0,0.0,1.0,N-terminal amphipathic regulatory helices,True,assigned_too_few_test_positives +13980,87239,17.511642,0.7988281,CF(1),keyword,87239,CF(1),0.7988281,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9714014304872597,0.5075454296510684,0.008861320336730172,0.95,57.27650173612307,0.0,15.0,0.0,1.0,Nucleotidyltransferase helical lid scaffold,True,assigned_and_evaluated +13981,36776,20.301561,0.984375,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.71728516,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9981489708277803,0.5527777777777777,0.002658396101019052,0.6666666666666666,207.93657407407403,13.0,17.0,243.81031770997168,1.613717127467711e-29,PTM-rich nuclear IDR tails,True,assigned_and_evaluated +13982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bromodomain and HTH core signature,False,no_term_above_threshold +13983,64148,15.752381,0.6088867,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.6088867,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.5201777903203048,0.060606767250425575,0.008418254319893664,0.05263157894736842,7.199445983379501,4.0,16.0,22.246641791044777,4.784457211057719e-05,N-terminal HTH/helix-cap motifs,True,assigned_and_evaluated +13984,82716,16.22397,0.9140625,Laminin,gene3d,88058,Signal,0.6484375,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,2.0,19.0,30.46550843127235,0.00339944169433578,Extracellular mucin-like PTS stalks,True,assigned_too_few_test_positives +13985,50338,20.883343,0.8261719,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.7631836,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase core motif,True,assigned_too_few_test_positives +13986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trp-centered class-I PLP motif,False,no_term_above_threshold +13987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered docking motifs,False,no_term_above_threshold +13988,36977,18.702599,0.97265625,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.89160156,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,13.0,0.0,1.0,Kinase N-lobe alphaC helix,True,assigned_too_few_test_positives +13989,85682,27.0924,0.71777344,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.71777344,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7320698924731183,0.4423164619924595,0.011076650420912717,0.44,39.932330188679245,13.0,14.0,94.9611614800294,2.7710605294371066e-25,E1 adenylation Cys-loop,True,assigned_and_evaluated +13990,32561,18.444942,0.8623047,"proton-transporting ATPase activity, rotational mechanism",go_mf,32561,"proton-transporting ATPase activity, rotational mechanism",0.8623047,35,go,GO:0046961,go_mf:go:GO:0046961,,,,,,,,2.0,19.0,66.76483762597984,0.0007367551740800727,Elongated coiled-coil scaffolds,True,assigned_too_few_test_positives +13991,64148,25.549059,0.7138672,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.7138672,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.807229199002869,0.2904267286793813,0.008418254319893664,0.15789473684210525,34.499638243650715,16.0,16.0,88.9865671641791,2.2195284459665565e-31,HTH N-terminal leader helix,True,assigned_and_evaluated +13992,52941,17.57822,0.8457031,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.6464844,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,13.0,0.0,1.0,Hydrophobic tetraspan TM helices,True,assigned_too_few_test_positives +13993,38317,16.07812,0.9082031,Pentatricopeptide repeat,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8959961,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8323174603174603,0.009911663776774908,0.0031014621178555605,,3.1958035920258525,0.0,14.0,0.0,1.0,Hydrophobic helical packing residues,True,assigned_and_evaluated +13994,87317,16.297037,0.67529297,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.67529297,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.7034666443551986,0.17882599326178808,0.007089056269384138,0.125,25.22564167449098,10.0,17.0,49.675887352107985,2.1628488563617304e-15,N-terminal leaders and propeptides,True,assigned_and_evaluated +13995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic lid hinge loops,False,no_term_above_threshold +13996,45714,18.813898,0.7519531,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.7519531,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,14.0,0.0,1.0,ABC coupling loop helices,True,assigned_too_few_test_positives +13997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helical pore/anchor residues,False,no_term_above_threshold +13998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue TM helix packing,False,no_term_above_threshold +13999,87276,32.768513,0.6308594,Cell membrane,keyword,88161,Transmembrane helix,0.61376953,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.752192625311317,0.5503211702138407,0.11120957022596367,0.5338645418326693,4.948505502679835,14.0,15.0,7.658445728965961,4.56869047873713e-12,Transmembrane helix interfacial caps,True,assigned_and_evaluated +14000,88058,28.675209,0.6777344,Signal,keyword,88058,Signal,0.6777344,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6916813015673151,0.13065793246765567,0.09127159946832078,,1.4315289008713536,0.0,20.0,0.0,1.0,IDR and signal peptide detector,True,assigned_and_evaluated +14001,36449,20.560284,0.9951172,EamA domain,interpro,36449,EamA domain,0.9951172,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,17.0,0.0,1.0,Lipid-linked glycan gate helix,True,assigned_too_few_test_positives +14002,37020,22.88012,0.9946289,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.93652344,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,11.0,17.0,528.4697824335213,1.791889579266846e-28,Carbohydrate-recognition surface loops,True,assigned_too_few_test_positives +14003,36535,17.90141,0.9433594,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9379883,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.947196261682243,0.9004430660168365,0.004430660168365086,0.9,203.23000000000002,13.0,13.0,89.79066265060241,1.1174852366600676e-25,APE/P+1 activation signature,True,assigned_and_evaluated +14004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycogenin-like GT-A/GT8 catalytic domain,False,no_term_above_threshold +14005,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic active-site motifs,False,no_term_above_threshold +14006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended amphipathic helical scaffolds,False,no_term_above_threshold +14007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface helix termini,False,no_term_above_threshold +14008,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TEP beta-chain internal activation,False,no_term_above_threshold +14009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regional activation near conserved termini,False,no_term_above_threshold +14010,64016,40.192505,0.94873047,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.94873047,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.8541587301587302,0.42310835425589527,0.0031014621178555605,0.7142857142857143,136.42222222222222,12.0,13.0,204.59022018873318,2.3752269866491593e-27,Cys/Sec–Pro active-site neighborhood,True,assigned_and_evaluated +14011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"2OG dioxygenase N-termini, chemokines",False,no_term_above_threshold +14012,50338,16.465475,0.6816406,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.6816406,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,13.0,0.0,1.0,EPSPS/MurA chain-wide activation,True,assigned_too_few_test_positives +14013,42054,15.932948,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,17.0,17.0,677.5113636363636,6.533334885052963e-48,Radical SAM core activation,True,assigned_too_few_test_positives +14014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CE4 polysaccharide N-deacetylases,False,no_term_above_threshold +14015,49116,26.163923,0.98046875,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.98046875,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9994671403197158,0.6861904761904761,0.002215330084182543,1.0,309.74638095238095,20.0,20.0,87.03795620437957,8.990576307619231e-39,HEAT/ARM helix-turn boundaries,True,assigned_and_evaluated +14016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-propeller and beta-helix activation,False,no_term_above_threshold +14017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tryptophan-paired glycan-binding surfaces,False,no_term_above_threshold +14018,85664,21.886602,0.9550781,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9550781,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,Short amphipathic interface helices,True,assigned_too_few_test_positives +14019,37446,17.678709,0.9658203,F-box domain,interpro,63831,F-box-like domain superfamily,0.96533203,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9393650793650792,0.031576298047971484,0.0031014621178555605,,10.181100670610235,0.0,17.0,0.0,1.0,Strand starts and helix caps,True,assigned_and_evaluated +14020,37894,24.104893,0.8227539,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.8227539,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,Repetitive surface adhesin scaffolds,True,assigned_too_few_test_positives +14021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DENN subdomains and acidic linkers,False,no_term_above_threshold +14022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal basic disordered targeting segments,False,no_term_above_threshold +14023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered helical linkers,False,no_term_above_threshold +14024,36104,27.629366,0.9614258,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9614258,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Cationic anion-binding motifs,True,assigned_too_few_test_positives +14025,49045,16.656555,0.9902344,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98046875,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,5.0,19.0,142.633971291866,4.6304303585009446e-10,Secreted beta-propeller strand-turn signature,True,assigned_too_few_test_positives +14026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved amphipathic coupling helices,False,no_term_above_threshold +14027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Arg-rich linker and Walker A,False,no_term_above_threshold +14028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site flanking core residues,False,no_term_above_threshold +14029,85364,16.006065,0.9477539,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9477539,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,0.0,17.0,0.0,1.0,Active site proximal beta strands,True,assigned_too_few_test_positives +14030,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease catalytic contact segment,False,no_term_above_threshold +14031,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-peptide hydrophobic helix detector,False,no_term_above_threshold +14032,58239,17.5659,0.74609375,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.74609375,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7449481281010374,0.035061184976492854,0.017722640673460344,,1.9783273622986095,0.0,14.0,0.0,1.0,Electrostatic polyanion-binding surfaces,True,assigned_and_evaluated +14033,63831,17.019255,0.9057617,F-box-like domain superfamily,interpro,43624,Homedomain-like superfamily,0.88427734,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8756108396268326,0.011632337587736194,0.002658396101019052,,4.375697655920098,0.0,18.0,0.0,1.0,Isolated soluble alpha-helical residues,True,assigned_and_evaluated +14034,88161,35.95084,0.61572266,Transmembrane helix,keyword,88161,Transmembrane helix,0.61572266,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.621239964550099,0.36358371288761515,0.1847585290208241,0.2949640287769784,1.9678859472118644,16.0,20.0,4.341993627674102,8.051579656654617e-09,Hydrophobic signal peptide/anchor helix,True,assigned_and_evaluated +14035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended amphipathic helical interfaces,False,no_term_above_threshold +14036,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtadomain helical linkers,False,no_term_above_threshold +14037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended catalytic interface segments,False,no_term_above_threshold +14038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged eukaryotic binding interfaces,False,no_term_above_threshold +14039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amidase_3 catalytic loop motif,False,no_term_above_threshold +14040,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intein/HINT insertion hotspots,False,no_term_above_threshold +14041,36535,30.926296,0.9716797,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.86572266,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9494214508233199,0.8158795739533444,0.004430660168365086,0.9,184.14401984126985,19.0,19.0,89.79066265060241,3.7420828801112705e-37,Conserved kinase C-lobe hotspot,True,assigned_and_evaluated +14042,84152,27.330414,0.9243164,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9243164,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,14.0,14.0,562.4622641509434,9.417075282476258e-39,Charged catalytic and binding surfaces,True,assigned_too_few_test_positives +14043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MutY Nudix hydrolase domain,False,no_term_above_threshold +14044,82029,23.075357,0.9863281,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6333008,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,TM helix ends and kinks,True,assigned_too_few_test_positives +14045,87317,17.816917,0.8154297,Cleavage on pair of basic residues,keyword,88058,Signal,0.7524414,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9489067380633646,0.21468149647451204,0.007089056269384138,,30.283508596435855,1.0,19.0,4.444684657820187,0.3198233686329762,Cleaved secretory signal peptide,True,assigned_and_evaluated +14046,85712,16.453588,0.8886719,3.40.630.30,gene3d,49230,Acyl-CoA N-acyltransferase,0.8828125,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,13.0,0.0,1.0,Active-site pre‑β loops,True,assigned_too_few_test_positives +14047,83267,23.261164,0.99560547,DNA-binding pseudobarrel domain,gene3d,48767,DNA-binding pseudobarrel domain superfamily,0.9951172,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,17.0,0.0,1.0,C-terminal SET/post-SET catalytic region,True,assigned_too_few_test_positives +14048,88009,16.560528,0.60839844,Repeat,keyword,88009,Repeat,0.60839844,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7899269341475069,0.25307033441544946,0.07266282676118742,0.024390243902439025,3.4828033218028622,4.0,14.0,2.533021773765268,0.10494367940804548,β-sheet edge binding surfaces,True,assigned_and_evaluated +14049,87484,16.964277,0.77978516,G-protein coupled receptor,keyword,88161,Transmembrane helix,0.64208984,44,keywords,G-protein coupled receptor,keyword:keywords:G-protein coupled receptor,,,,,,,,0.0,18.0,0.0,1.0,Amphipathic cytosolic TM–TM linkers,True,assigned_too_few_test_positives +14050,87326,40.802425,0.7783203,Coiled coil,keyword,87326,Coiled coil,0.7783203,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.847270305568224,0.3612002117174304,0.03943287549844927,0.449438202247191,9.15987503198023,13.0,19.0,8.626203381153243,1.7506259806341123e-10,Non-transmembrane coiled-coil detector,True,assigned_and_evaluated +14051,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribosyltransferase catalytic core,False,no_term_above_threshold +14052,87326,36.589764,0.6977539,Coiled coil,keyword,87326,Coiled coil,0.6977539,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7175307848584103,0.34252156997025784,0.03943287549844927,0.38202247191011235,8.6861930721671,17.0,17.0,12.607528018608585,4.8104034305401955e-19,Heptad-repeat coiled-coil rods,True,assigned_and_evaluated +14053,50338,20.455713,0.82958984,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.82958984,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,Hydrophobic hinge/microswitch elements,True,assigned_too_few_test_positives +14054,36091,16.408878,0.8623047,GNAT domain,interpro,43624,Homedomain-like superfamily,0.69970703,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,17.0,0.0,1.0,J-domain HPD catalytic loop,True,assigned_too_few_test_positives +14055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NB-ARC C-terminal helix,False,no_term_above_threshold +14056,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Q/H-rich low-complexity IDRs,False,no_term_above_threshold +14057,85762,32.789505,0.9199219,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.9199219,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,19.0,194.76914700544464,2.2832588019143797e-40,FAD/NAD(P)H Rossmann loop,True,assigned_too_few_test_positives +14058,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved C-terminal MLH1-binding helix,False,no_term_above_threshold +14059,52236,23.39526,0.99853516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.99560547,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,17.0,223.29962546816478,5.889205604949045e-40,TPR helix B C-terminus,True,assigned_too_few_test_positives +14060,47529,25.701113,0.9399414,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9399414,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.961289602855868,0.5712248670989024,0.007089056269384138,0.625,80.57840781513892,14.0,18.0,60.14512177547197,2.7100217262699095e-23,Ig/FNIII ectodomains and stalks,True,assigned_and_evaluated +14061,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GlyRS beta C-terminal helix motif,False,no_term_above_threshold +14062,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible low-complexity linkers,False,no_term_above_threshold +14063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide signaling catalytic loops,False,no_term_above_threshold +14064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global disorder and coiled-coil activation,False,no_term_above_threshold +14065,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended C-terminal tail region,False,no_term_above_threshold +14066,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil helical scaffolds,False,no_term_above_threshold +14067,48241,18.720137,0.9848633,RmlC-like jelly roll fold,interpro,46082,PH-like domain superfamily,0.8876953,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,18.0,18.0,387.14935064935065,2.6960306916448084e-46,His-Asp/Glu metal-binding loop,True,assigned_too_few_test_positives +14068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sestrin N-terminal helix hotspot,False,no_term_above_threshold +14069,36354,18.013899,1.0,RNA recognition motif domain,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9995117,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,17.0,19.0,191.88886785308594,1.5481058173752871e-37,Spliceosomal RRM helix-loop activation,True,assigned_too_few_test_positives +14070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered terminal tails,False,no_term_above_threshold +14071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural core assembly regions,False,no_term_above_threshold +14072,37282,18.785913,0.8857422,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.84716797,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,16.0,17.0,210.16435338180213,1.624802082425761e-36,LRR hydrophobic turn motif,True,assigned_too_few_test_positives +14073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-to-strand capping turn,False,no_term_above_threshold +14074,49116,22.547037,0.8676758,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8676758,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8965808170515098,0.5426652882390588,0.002215330084182543,0.6,244.95911111111116,10.0,18.0,48.3544201135442,3.544815943299699e-15,HEAT/ARM alpha-solenoids and lipovitellin cores,True,assigned_and_evaluated +14075,88161,51.58476,0.65478516,Transmembrane helix,keyword,88161,Transmembrane helix,0.65478516,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6479824835783548,0.4029736723016212,0.1847585290208241,0.3405275779376499,2.181082921785993,17.0,18.0,5.12596469933748,1.0375329726883646e-11,Cytosolic juxtamembrane N-termini,True,assigned_and_evaluated +14076,87697,20.058342,0.80615234,Knottin,keyword,87697,Knottin,0.80615234,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.81546669441169,0.047245780809780744,0.017279574656623838,,2.734198135581414,0.0,13.0,0.0,1.0,GARIN central LxLTR motif,True,assigned_and_evaluated +14077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal outer-membrane β-barrels,False,no_term_above_threshold +14078,36104,22.310966,0.9946289,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9946289,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,12.0,0.0,1.0,Active-site-adjacent charged loops,True,assigned_too_few_test_positives +14079,85388,23.617641,0.6899414,Glutaredoxin,gene3d,64016,Thioredoxin-like superfamily,0.68847656,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.8715262338817252,0.3958380551105961,0.003544528134692069,0.25,111.67581129807694,17.0,20.0,184.2830909090909,7.934761708489809e-37,GST-like G-site detector,True,assigned_and_evaluated +14080,49236,17.744516,0.7348633,C-type lectin fold,interpro,49236,C-type lectin fold,0.7348633,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.5968028419182949,0.04177226406734604,0.002215330084182543,,18.856000000000005,0.0,16.0,0.0,1.0,First propeller blade activation,True,assigned_and_evaluated +14081,24917,16.037731,0.63134766,nucleus,go_cc,24917,nucleus,0.63134766,1728,go,GO:0005634,go_cc:go:GO:0005634,132.0,2257.0,0.8402549019607843,0.19651119470830183,0.05848471422241914,,3.360043685277555,9.0,18.0,2.8600690780005755,0.00280247178784538,Disordered PPI motif regions,True,assigned_and_evaluated +14082,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide lobe beta-strand motif,False,no_term_above_threshold +14083,81685,23.415213,0.96875,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9667969,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9566629547141796,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,16.0,16.0,85.66235632183908,4.040725274098586e-31,Kinase catalytic-loop KPXN motif,True,assigned_and_evaluated +14084,36272,17.48623,0.9785156,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,88164,Transposition,0.73339844,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,15.0,0.0,1.0,Context-dependent catalytic core activation,True,assigned_too_few_test_positives +14085,43624,16.16581,0.62890625,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.62890625,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.6716728023203927,0.032123483781230464,0.007089056269384138,,4.5314189308898225,0.0,8.0,0.0,1.0,Sigma -10 recognition helix,True,assigned_and_evaluated +14086,36104,18.75887,0.8129883,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8129883,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,N-terminal alpha-helical caps,True,assigned_too_few_test_positives +14087,28622,19.164448,0.87646484,transposase activity,go_mf,88163,Transposable element,0.7128906,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.9968916518650088,0.29929824561403506,0.002215330084182543,,135.10322807017545,4.0,15.0,305.7487179487179,1.4413471059419646e-09,DDE/DDD transposase/integrase core,True,assigned_and_evaluated +14088,63892,17.434412,0.9892578,Fibronectin type III superfamily,interpro,47529,Immunoglobulin-like fold,0.77246094,39,ip,IPR036116,interpro:ip:IPR036116,,,,,,,,18.0,18.0,289.42233009708735,4.0738218914291243e-44,Extracellular FN3 tandem repeats,True,assigned_too_few_test_positives +14089,55053,24.957829,0.9838867,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9838867,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,15.0,15.0,552.0462962962963,2.7547180682567216e-41,Soluble acyl-CoA acyltransferase core,True,assigned_too_few_test_positives +14090,47529,22.825695,0.9375,Immunoglobulin-like fold,interpro,88058,Signal,0.6113281,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9849118697010264,0.2856268488270489,0.007089056269384138,0.0625,40.29123736266559,11.0,18.0,47.2568813950137,1.114202316232903e-16,Extracellular beta-strand signature,True,assigned_and_evaluated +14091,43624,16.351055,0.8154297,Homedomain-like superfamily,interpro,43624,Homedomain-like superfamily,0.8154297,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.8659499107541276,0.03419243239483788,0.007089056269384138,,4.823269994696818,0.0,16.0,0.0,1.0,Short amphipathic helical patches,True,assigned_and_evaluated +14092,49061,28.136986,0.96240234,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96240234,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9923492277126195,0.4220652454470261,0.012405848471422242,0.9642857142857143,34.021473534783496,2.0,14.0,14.124851930822079,0.014644381684275242,Beta-strand start signal,True,assigned_and_evaluated +14093,47529,26.88837,0.9609375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9609375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9936412315930387,0.5232603553689188,0.007089056269384138,0.5,73.8124138792281,15.0,18.0,64.4412019022914,1.0108141398209011e-25,Ig-like strand-loop turns,True,assigned_and_evaluated +14094,69819,22.22416,0.9692383,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.94873047,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,17.0,17.0,419.86619718309856,1.776833158726609e-44,Internal actin-fold ATPase motif,True,assigned_too_few_test_positives +14095,45288,18.60776,0.9995117,CheY-like superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.86572266,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,15.0,15.0,462.17829457364337,3.960299025280445e-40,Amphipathic REC/DHp helices,True,assigned_too_few_test_positives +14096,45804,16.728014,0.9794922,Major facilitator superfamily,interpro,37446,F-box domain,0.9482422,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,2.0,20.0,27.602314814814815,0.004124626677102927,PAS helix-capping hinge motifs,True,assigned_too_few_test_positives +14097,45324,21.906534,0.9272461,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9272461,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9995559502664298,0.71,0.002215330084182543,1.0,320.494,5.0,14.0,195.35058977719527,7.821554113927303e-11,Polar low-complexity repeats,True,assigned_and_evaluated +14098,45804,18.28796,0.99072266,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.6357422,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,13.0,17.0,211.0765250544662,1.0576629342134888e-28,Transporter TM helices and caps,True,assigned_too_few_test_positives +14099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular SGNH/GDSL O-acyl esterases/acyltransferases,False,no_term_above_threshold +14100,4066,20.725307,0.84472656,type II site-specific deoxyribonuclease,ec,4066,type II site-specific deoxyribonuclease,0.84472656,44,ec,3.1.21.4,ec:ec:3.1.21.4,5.0,2257.0,0.5903197158081706,0.008915121210203178,0.002215330084182543,,4.024285714285715,3.0,20.0,107.7487951807229,5.5216431052830985e-06,Endonuclease domains and HhH patches,True,assigned_and_evaluated +14101,61392,15.734686,0.92041016,Leucine-rich repeat domain superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7495117,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9594603174603175,0.04163757221382347,0.0031014621178555605,,13.425142926657081,0.0,12.0,0.0,1.0,Conserved hydrophobic anchor motif,True,assigned_and_evaluated +14102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal regulatory targeting modules,False,no_term_above_threshold +14103,45714,16.606188,0.9692383,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.9692383,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,Histone-fold modules and tails,True,assigned_too_few_test_positives +14104,82107,17.30448,0.69140625,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.66796875,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,10.0,0.0,1.0,Prenyltransferase RRGxPCW loop,True,assigned_too_few_test_positives +14105,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting modules,False,no_term_above_threshold +14106,63960,32.541916,0.78759766,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.78759766,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,14.0,14.0,193.57467532467533,3.081977033971596e-32,Glycine-rich terminal redox cap,True,assigned_too_few_test_positives +14107,88006,16.202724,0.6958008,Receptor,keyword,87522,Glycoprotein,0.6040039,160,keywords,Receptor,keyword:keywords:Receptor,10.0,2257.0,0.630752113929684,0.030194092273366037,0.004430660168365086,,6.814806626098715,7.0,19.0,21.284526723786207,3.826189713061709e-08,Type I membrane cytosolic tails,True,assigned_and_evaluated +14108,37282,27.71831,0.9995117,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.9433594,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,3.0,12.0,55.824906367041194,3.5194515350566226e-05,RTX calcium-binding repeats,True,assigned_too_few_test_positives +14109,88160,20.416695,0.8354492,Transmembrane beta strand,keyword,25167,cell outer membrane,0.69970703,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,18.0,209.02723840345197,1.986057124442724e-28,Outer-membrane beta-barrel signature,True,assigned_too_few_test_positives +14110,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteolytic maturation domain hotspots,False,no_term_above_threshold +14111,36354,25.301935,0.9511719,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.94189453,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,9.0,0.0,1.0,ABC NBD adenine-binding A-loop,True,assigned_too_few_test_positives +14112,46082,17.822224,0.8076172,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.8076172,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.704952380952381,0.09288749803972285,0.0031014621178555605,,29.949583296522068,0.0,14.0,0.0,1.0,Membrane-proximal beta modules,True,assigned_and_evaluated +14113,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV C-terminal PAC helix,False,no_term_above_threshold +14114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD-adjacent substrate channel cap,False,no_term_above_threshold +14115,72011,15.963124,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9746094,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,11.0,19.0,341.75664408546123,4.424699527134814e-26,ANL A3 loop motif,True,assigned_too_few_test_positives +14116,85791,15.833428,0.99121094,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.99072266,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,17.0,0.0,1.0,Phosphoesterase active-site beta strands,True,assigned_too_few_test_positives +14117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease-associated beta-sandwich domain,False,no_term_above_threshold +14118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLD HKD catalytic microenvironment,False,no_term_above_threshold +14119,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal basic phosphate-binding helix,False,no_term_above_threshold +14120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged N-terminal helix-coil boundary,False,no_term_above_threshold +14121,81858,18.05874,0.8989258,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.64404297,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane helix loop interfaces,True,assigned_too_few_test_positives +14122,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed extramembrane domains,False,no_term_above_threshold +14123,85364,18.968351,0.7861328,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7861328,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Extracytoplasmic binding site lids,True,assigned_too_few_test_positives +14124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered tails,False,no_term_above_threshold +14125,58239,16.867891,0.71191406,P-loop containing nucleoside triphosphate hydrolase,interpro,87601,Hydrolase,0.61328125,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7847598105548037,0.12308500242544179,0.017722640673460344,,6.945071261855554,1.0,15.0,2.3900982160753657,0.5403976437680915,Beta-strand N-cap motif,True,assigned_and_evaluated +14126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal activation in processed proteins,False,no_term_above_threshold +14127,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytoplasmic Calx-beta domain,False,no_term_above_threshold +14128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular functional domains,False,no_term_above_threshold +14129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early N-terminal helix/loop,False,no_term_above_threshold +14130,47717,16.430967,0.8886719,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.63378906,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,15.0,255.25810397553516,3.4181598419221845e-33,SF2 helicase ATPase lobe helix,True,assigned_too_few_test_positives +14131,63951,19.6613,0.96191406,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9555664,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.993574535389482,0.2597096283877893,0.003987594151528578,,65.12940347458228,9.0,17.0,85.30826709062003,6.864165146895962e-16,Extracellular beta-sandwich edge strands,True,assigned_and_evaluated +14132,38317,15.562802,0.87646484,Pentatricopeptide repeat,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8588867,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7431428571428572,0.006844391082793845,0.0031014621178555605,,2.2068272391236725,0.0,11.0,0.0,1.0,Auxiliary-domain helical hinge,True,assigned_and_evaluated +14133,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TFIIB-family conserved linker peak,False,no_term_above_threshold +14134,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich regulatory IDRs,False,no_term_above_threshold +14135,69819,20.5929,0.84033203,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8364258,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,17.0,17.0,419.86619718309856,1.776833158726609e-44,FGGY C-terminal beta-strand motif,True,assigned_too_few_test_positives +14136,49116,23.910082,0.9711914,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9711914,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9981349911190054,0.7516666666666667,0.002215330084182543,0.8,339.30233333333337,12.0,19.0,54.97134076066077,5.701372624473585e-19,HEAT/ARM alpha-solenoid interfaces,True,assigned_and_evaluated +14137,37071,18.884697,0.9609375,Homeodomain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.93066406,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,18.0,0.0,1.0,Helix-cap hinge SLiMs,True,assigned_too_few_test_positives +14138,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered interaction module,False,no_term_above_threshold +14139,87882,16.669054,0.7504883,Palmitate,keyword,88058,Signal,0.7392578,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.6452317488523619,0.004821384500699628,0.002658396101019052,,1.8136441363465101,1.0,19.0,3.506086445163187,0.39266262210132363,Signal peptide/anchor helix,True,assigned_and_evaluated +14140,63774,20.097927,0.9814453,RNA-binding domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9790039,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,17.0,0.0,1.0,Helix C-cap turn-strand connector,True,assigned_too_few_test_positives +14141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM helices and tail,False,no_term_above_threshold +14142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AlaRS/AlaX conserved C-terminus,False,no_term_above_threshold +14143,85682,18.058832,0.8413086,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8413086,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9514784946236559,0.17870965264031305,0.011076650420912717,,16.133907440367462,1.0,10.0,10.226586620926243,0.15170572608009017,Catalytic core helix caps,True,assigned_and_evaluated +14144,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal TM bundle and tail,False,no_term_above_threshold +14145,52236,22.640364,0.99316406,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.96875,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,17.0,18.0,210.8940907199334,9.175234661021449e-39,N-terminal TPR A-helix,True,assigned_too_few_test_positives +14146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed interaction patches,False,no_term_above_threshold +14147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isolated alpha-helix residue peaks,False,no_term_above_threshold +14148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble acidic catalytic cores,False,no_term_above_threshold +14149,52236,30.037865,0.98828125,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9394531,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,19.0,19.0,223.29962546816478,2.2408398621355094e-44,TPR/SEL1 loop-to-helix hotspots,True,assigned_too_few_test_positives +14150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered linkers and helices,False,no_term_above_threshold +14151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site rim anchors,False,no_term_above_threshold +14152,85672,26.698833,0.66503906,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.66259766,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6336735204362399,0.17090647308972778,0.01595037660611431,0.2777777777777778,10.714886382319879,18.0,18.0,40.01409395973155,4.696317832916793e-29,Post P-loop coupling region,True,assigned_and_evaluated +14153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein soluble domains,False,no_term_above_threshold +14154,64058,25.786325,0.97558594,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9614258,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9894274250047768,0.4529292806895255,0.006202924235711121,0.2857142857142857,73.01867046544707,19.0,20.0,108.29818355640533,7.902884390031198e-38,NAD(P)-binding Rossmann β–α loop,True,assigned_and_evaluated +14155,36409,18.300816,0.91015625,"Zinc finger, CCCH-type",interpro,87681,Iron-sulfur,0.8725586,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,15.0,0.0,1.0,Cys-rich metal-binding loops,True,assigned_too_few_test_positives +14156,88058,93.11824,0.8730469,Signal,keyword,88058,Signal,0.8730469,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.8997919556171983,0.6860157990345277,0.09127159946832078,0.8300970873786407,7.5162022253443155,16.0,17.0,6.781133819086547,6.166750729974937e-13,Signal peptidase cleavage motif,True,assigned_and_evaluated +14157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short disordered polar linkers,False,no_term_above_threshold +14158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended amphipathic coiled-coils,False,no_term_above_threshold +14159,85664,20.839684,0.84472656,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.84472656,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,9.0,17.0,175.3558823529412,1.016577259850828e-18,Glycosyltransferase nucleotide-sugar binding patch,True,assigned_too_few_test_positives +14160,38873,15.903388,0.76220703,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6855469,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7941385435168739,0.08960793654495121,0.002215330084182543,,40.44902255639098,7.0,10.0,119.9272988505747,5.867668631332058e-14,Post-Walker transducer segment,True,assigned_and_evaluated +14161,82764,15.774398,0.87646484,Kelch-type beta propeller,gene3d,82764,Kelch-type beta propeller,0.87646484,38,gene3d,2.120.10.80,gene3d:gene3d:2.120.10.80,,,,,,,,0.0,16.0,0.0,1.0,Beta-repeat boundary anchors,True,assigned_too_few_test_positives +14162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CP1 editing domain,False,no_term_above_threshold +14163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved interdomain EEFLxGK motif,False,no_term_above_threshold +14164,85649,15.786853,0.6333008,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.63183594,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.5604297224709042,0.043022811019959986,0.0101905183872397,,4.2218471509586815,0.0,15.0,0.0,1.0,Disordered terminal interaction tails,True,assigned_and_evaluated +14165,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core transmembrane helix,False,no_term_above_threshold +14166,85664,22.227888,0.92626953,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.92626953,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,4.0,14.0,94.63650793650794,1.549107252192802e-07,Glycosyltransferase pre-catalytic segment,True,assigned_too_few_test_positives +14167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GA-rich C-terminal tails,False,no_term_above_threshold +14168,37020,16.996159,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9707031,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,19.0,687.7692862292718,7.07564378350904e-44,GT β→α donor loop,True,assigned_too_few_test_positives +14169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pocket-flanking loop residues,False,no_term_above_threshold +14170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic enzyme core segments,False,no_term_above_threshold +14171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal polar linker loops,False,no_term_above_threshold +14172,27936,15.8181305,0.80029297,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.80029297,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,6.0,13.0,295.8858560794045,4.763904003359144e-14,PPIase beta-sheet core elements,True,assigned_too_few_test_positives +14173,36535,17.834124,0.6459961,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.64453125,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.6986203827325322,0.1631742691168921,0.004430660168365086,0.1,36.828432539682545,12.0,13.0,82.88368860055607,1.18247070589723e-22,Kinase C-lobe helix–coil module,True,assigned_and_evaluated +14174,59229,26.695662,0.7529297,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7529297,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.7348487797283095,0.41904329729682965,0.0101905183872397,0.4782608695652174,41.12090095647584,12.0,13.0,98.10119292472234,1.5893007827992264e-23,SAM MTase N-terminal cap,True,assigned_and_evaluated +14175,46082,18.472286,0.9824219,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9824219,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9995555555555555,0.9004329004329004,0.0031014621178555605,1.0,290.32529375386514,14.0,17.0,124.30290394638868,5.649651860167436e-28,Phosphoinositide-binding PH domains,True,assigned_and_evaluated +14176,84152,18.149172,0.8535156,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8535156,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,18.0,18.0,562.4622641509434,5.407112538669923e-49,Amidohydrolase TIM-barrel core helix,True,assigned_too_few_test_positives +14177,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early structured interface segment,False,no_term_above_threshold +14178,64620,19.72465,0.8647461,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.8647461,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,17.0,18.0,306.02566425120773,1.8311978117722885e-41,GHKL ATP-lid glycine motifs,True,assigned_too_few_test_positives +14179,46581,16.278202,0.9501953,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9501953,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,0.0,17.0,0.0,1.0,Short β-edge/loop motifs,True,assigned_too_few_test_positives +14180,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HisRS-like tRNA-binding surfaces,False,no_term_above_threshold +14181,85364,26.92791,0.86328125,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.86328125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,20.0,20.0,301.1161616161616,6.727542491261737e-49,Hinge/cap helix-loop-helix hairpin,True,assigned_too_few_test_positives +14182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,beta-strand edge loops,False,no_term_above_threshold +14183,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic Gly/Pro beta-loop patches,False,no_term_above_threshold +14184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged N-terminal assembly helix,False,no_term_above_threshold +14185,50338,16.809837,0.68359375,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.6425781,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,11.0,0.0,1.0,Ion transporter TM helices,True,assigned_too_few_test_positives +14186,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensor-effector coupling linkers,False,no_term_above_threshold +14187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Redox/metallo α/β enzyme cores,False,no_term_above_threshold +14188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate kinase-like N-terminal substrate-binding lobe,False,no_term_above_threshold +14189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic early OM β-strand turns,False,no_term_above_threshold +14190,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered S/T-rich phospho-regulatory regions,False,no_term_above_threshold +14191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flexible glycine-rich junction loops,False,no_term_above_threshold +14192,45288,18.179096,0.9760742,CheY-like superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.765625,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,0.0,10.0,0.0,1.0,ABC Walker B hydrophobe,True,assigned_too_few_test_positives +14193,87317,21.12736,0.89501953,Cleavage on pair of basic residues,keyword,88058,Signal,0.7246094,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9413487282463185,0.22265127649046032,0.007089056269384138,,31.40774568993556,13.0,18.0,60.990950582310354,1.7693239662865692e-21,Dibasic proprotein cleavage sites,True,assigned_and_evaluated +14194,45551,17.460676,0.9550781,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9550781,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,16.0,0.0,1.0,Central Lys-punctuated Gly/Ala helix,True,assigned_too_few_test_positives +14195,81685,24.839897,0.96972656,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.95947266,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9576466221232368,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,17.0,17.0,85.66235632183908,5.1673760881485446e-33,Kinase activation loop,True,assigned_and_evaluated +14196,64155,16.178267,0.7270508,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.7055664,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,0.0,10.0,0.0,1.0,TOPRIM/serine recombinase catalytic core,True,assigned_too_few_test_positives +14197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core neighborhood,False,no_term_above_threshold +14198,87326,16.524797,0.6064453,Coiled coil,keyword,87326,Coiled coil,0.6064453,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.651275965006841,0.10987843763822824,0.03943287549844927,,2.7864677949379906,14.0,19.0,9.2897574873958,6.607499695334387e-12,Coiled-coil hinge interruptions,True,assigned_and_evaluated +14199,59229,22.549025,0.92041016,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.8261719,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9662722354131797,0.16268588194097575,0.0101905183872397,,15.964436327860097,0.0,16.0,0.0,1.0,Helix-loop-beta active-site cap,True,assigned_and_evaluated +14200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved basic helix-disorder motifs,False,no_term_above_threshold +14201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BAR/PRD membrane scaffolds,False,no_term_above_threshold +14202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix termini interfaces,False,no_term_above_threshold +14203,27936,16.813528,0.7988281,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.7988281,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,13.0,13.0,641.0860215053764,8.089005362793607e-37,N-terminal targeting with motif-boundary peaks,True,assigned_too_few_test_positives +14204,85682,16.552565,0.8046875,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8046875,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.960448028673835,0.15887946633120117,0.011076650420912717,,14.343638220380841,0.0,14.0,0.0,1.0,Pocket-lining beta-strand ends,True,assigned_and_evaluated +14205,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site coupling elements,False,no_term_above_threshold +14206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic flexible capping loops,False,no_term_above_threshold +14207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTase palm post-DLD activation,False,no_term_above_threshold +14208,55053,16.608282,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,13.0,552.0462962962963,5.9319613712133276e-36,NRPS Condensation His/Asn motif,True,assigned_too_few_test_positives +14209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic β-α catalytic region,False,no_term_above_threshold +14210,47529,25.876514,0.9501953,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9501953,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9955098170459616,0.6347886284124427,0.007089056269384138,0.8125,89.5448708954302,8.0,18.0,34.36864101455541,6.27513604968484e-11,Exposed beta-strands and linkers,True,assigned_and_evaluated +14211,82029,26.762075,0.99902344,MFS general substrate transporter like domains,gene3d,88162,Transport,0.61572266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,20.0,169.27097791798107,9.692152584541787e-39,MFS transmembrane helix hotspots,True,assigned_too_few_test_positives +14212,47531,16.8961,0.96972656,Aldolase-type TIM barrel,interpro,49230,Acyl-CoA N-acyltransferase,0.85498047,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,12.0,17.0,178.3280159521436,2.080998039415035e-25,Active-site beta-strand scaffolds,True,assigned_too_few_test_positives +14213,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad diffuse protein activation,False,no_term_above_threshold +14214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,tRNA splicing and RNAP I,False,no_term_above_threshold +14215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal-biased coiled-coil activation,False,no_term_above_threshold +14216,87489,16.82709,0.67041016,GPI-anchor,keyword,87489,GPI-anchor,0.67041016,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.7023492063492064,0.03462148112708941,0.0031014621178555605,,11.162954700548685,0.0,20.0,0.0,1.0,Secretory glycoprotein ectodomains,True,assigned_and_evaluated +14217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β–α hydrophobic motif,False,no_term_above_threshold +14218,37446,30.524714,0.99316406,F-box domain,interpro,63831,F-box-like domain superfamily,0.9926758,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9997460317460318,0.9325396825396826,0.0031014621178555605,1.0,300.6774376417234,17.0,19.0,208.37931743421052,3.8883714368893947e-38,CRL adaptor-proximal helices,True,assigned_and_evaluated +14219,32561,15.992562,0.83740234,"proton-transporting ATPase activity, rotational mechanism",go_mf,32561,"proton-transporting ATPase activity, rotational mechanism",0.83740234,35,go,GO:0046961,go_mf:go:GO:0046961,,,,,,,,11.0,15.0,465.1283687943262,3.787412153761626e-28,Elongated coiled-coil stalks,True,assigned_too_few_test_positives +14220,37007,16.096674,0.91503906,Metallo-beta-lactamase,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.90771484,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,0.0,18.0,0.0,1.0,HExxH metalloprotease active site,True,assigned_too_few_test_positives +14221,36951,17.6805,0.96240234,SET domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.88720703,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,13.0,0.0,1.0,Inactive SPT16 M24-like domain,True,assigned_too_few_test_positives +14222,45553,19.28262,0.97753906,Restriction endonuclease type II-like,interpro,45290,Protein kinase-like domain superfamily,0.9536133,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,2.0,14.0,97.89983579638752,0.000342359293854105,Conserved nuclease catalytic motifs,True,assigned_too_few_test_positives +14223,36535,18.616953,0.94921875,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9433594,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9479750778816199,0.8904430660168364,0.004430660168365086,0.9,200.97299999999998,17.0,17.0,89.79066265060241,2.357720211227094e-33,Juxtacatalytic kinase regulatory tails,True,assigned_and_evaluated +14224,36535,20.258934,0.95458984,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9482422,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9985758789497108,0.8920299145299145,0.004430660168365086,0.9,201.33115170940172,19.0,19.0,89.79066265060241,3.7420828801112705e-37,Kinase αF/αG helix motif,True,assigned_and_evaluated +14225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved core-stabilizing segments,False,no_term_above_threshold +14226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity scaffolds,False,no_term_above_threshold +14227,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical stalk linkers,False,no_term_above_threshold +14228,38317,18.230553,0.98583984,Pentatricopeptide repeat,interpro,88009,Repeat,0.671875,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9848888888888889,0.3063107759413178,0.0031014621178555605,0.2857142857142857,98.76334589993631,2.0,16.0,48.08145161290322,0.0013884880044786906,Alpha/beta solenoidal repeat scaffolds,True,assigned_and_evaluated +14229,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide second-messenger catalytic cores,False,no_term_above_threshold +14230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M4 metalloprotease C-terminal helices,False,no_term_above_threshold +14231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metalloenzyme C-terminal helix activation,False,no_term_above_threshold +14232,72011,15.99717,0.9824219,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85712,3.40.630.30,0.8833008,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,Cyclase catalytic-dimerization core,True,assigned_too_few_test_positives +14233,46078,16.417168,0.95214844,Armadillo-like helical,interpro,43624,Homedomain-like superfamily,0.9482422,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,14.0,16.0,114.40433114035088,7.68546904102013e-28,Helix N-cap/linker coil motifs,True,assigned_too_few_test_positives +14234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered cores and transmembrane helices,False,no_term_above_threshold +14235,45804,18.175846,0.7895508,Major facilitator superfamily,interpro,45804,Major facilitator superfamily,0.7895508,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,16.0,0.0,1.0,Small-residue transmembrane helix bundles,True,assigned_too_few_test_positives +14236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-sensing allosteric modules,False,no_term_above_threshold +14237,50869,18.980072,1.0,"DNA binding HTH domain, AraC-type",interpro,43624,Homedomain-like superfamily,0.62890625,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,18.0,18.0,917.2461538461538,1.209100928954895e-52,Alpha-helical interaction cores,True,assigned_too_few_test_positives +14238,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted SGNH/GDSL esterases,False,no_term_above_threshold +14239,59224,31.13573,0.82373047,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.82373047,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.8528888888888889,0.6033706040833624,0.0031014621178555605,0.5714285714285714,194.5439219165927,14.0,15.0,128.21720430107527,5.074985520296273e-29,Activation in noncatalytic lipase-fold regions,True,assigned_and_evaluated +14240,88009,16.59663,0.6113281,Repeat,keyword,88009,Repeat,0.6113281,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6323531982333679,0.1353263547557807,0.07266282676118742,,1.8623876992914452,8.0,19.0,3.732874192917237,0.0011034696223769728,Arginine-rich low-complexity tracts,True,assigned_and_evaluated +14241,85712,16.4739,0.95458984,3.40.630.30,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.92041016,65,gene3d,3.40.630.30,gene3d:gene3d:3.40.630.30,,,,,,,,0.0,19.0,0.0,1.0,Post-Walker A helix hydrophobe,True,assigned_too_few_test_positives +14242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tyrosine recombinase Lys motif,False,no_term_above_threshold +14243,37314,16.08534,0.9682617,"Helicase, C-terminal domain-like",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.90771484,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,11.0,14.0,249.17591185410336,2.513622064618288e-25,Helicase C-terminal accessory region,True,assigned_too_few_test_positives +14244,87276,46.28275,0.7373047,Cell membrane,keyword,88161,Transmembrane helix,0.7167969,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7399832375383809,0.42817129781494434,0.11120957022596367,0.5338645418326693,3.8501299568459335,19.0,20.0,7.795203688411781,1.7857579383583551e-16,Signal-anchor transmembrane helices,True,assigned_and_evaluated +14245,85364,21.174473,0.83984375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.83984375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,14.0,18.0,234.20145903479238,1.5626950716240022e-31,Ligand-binding pocket loop,True,assigned_too_few_test_positives +14246,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted peptide cores and N-caps,False,no_term_above_threshold +14247,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase lobe-2 coupling region,False,no_term_above_threshold +14248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase-receiver linker,False,no_term_above_threshold +14249,48767,20.640667,0.9897461,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9897461,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,18.0,0.0,1.0,C-terminal structured segment activator,True,assigned_too_few_test_positives +14250,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered tails and linkers,False,no_term_above_threshold +14251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Dehydratase/lyase catalytic cores,False,no_term_above_threshold +14252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix N-cap motif,False,no_term_above_threshold +14253,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cactin C-terminal motif,False,no_term_above_threshold +14254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SET-domain methyltransferase catalytic core,False,no_term_above_threshold +14255,87239,15.75113,0.8618164,CF(1),keyword,32555,"proton-transporting ATP synthase activity, rotational mechanism",0.81933594,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9982118909253465,0.665301660581981,0.008861320336730172,1.0,75.07929239667656,0.0,8.0,0.0,1.0,GrpE-like α/β interaction cores,True,assigned_and_evaluated +14256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered low-complexity repeats,False,no_term_above_threshold +14257,48241,24.231167,0.9536133,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9536133,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,18.0,18.0,387.14935064935065,2.6960306916448084e-46,Cupin N-terminal entry cap,True,assigned_too_few_test_positives +14258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-coordinating phosphate-binding segment,False,no_term_above_threshold +14259,85364,18.238947,0.7866211,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.7866211,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,0.0,11.0,0.0,1.0,Extracellular bilobal clamshell LBDs,True,assigned_too_few_test_positives +14260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycoside hydrolase active-site neighborhood,False,no_term_above_threshold +14261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic linker helices,False,no_term_above_threshold +14262,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scaffold non-repeat motif hotspots,False,no_term_above_threshold +14263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor binding surface patches,False,no_term_above_threshold +14264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small/polar active-site loop motifs,False,no_term_above_threshold +14265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,bis-MGD oxidoreductase cofactor interface,False,no_term_above_threshold +14266,72011,16.683847,0.9682617,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.8955078,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,20.0,0.0,1.0,DNA target-recognition patches,True,assigned_too_few_test_positives +14267,81858,18.479177,0.9355469,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6621094,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,2.0,17.0,30.764189886480906,0.003317090402528919,Cytosolic juxtamembrane helix motif,True,assigned_too_few_test_positives +14268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanionic low-complexity scaffolds,False,no_term_above_threshold +14269,63774,17.243639,0.94628906,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.94628906,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,17.0,0.0,1.0,Core beta-strand hydrophobic segments,True,assigned_too_few_test_positives +14270,87276,31.475054,0.62060547,Cell membrane,keyword,87276,Cell membrane,0.62060547,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7074861074148074,0.4457631772395859,0.11120957022596367,0.4541832669322709,4.008316697329663,12.0,14.0,7.033266485785065,1.5735186737564993e-09,Small-residue TM-helix cores,True,assigned_and_evaluated +14271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic β-sheet ligand surfaces,False,no_term_above_threshold +14272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +14273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded mature domain cores,False,no_term_above_threshold +14274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD-oxidoreductase C-terminal helix motif,False,no_term_above_threshold +14275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann NAD(P) β–α–β motif,False,no_term_above_threshold +14276,15821,17.20494,0.6899414,"transport of virus in host, cell to cell",go_bp,15821,"transport of virus in host, cell to cell",0.6899414,71,go,GO:0046740,go_bp:go:GO:0046740,,,,,,,,0.0,13.0,0.0,1.0,Acidic C2-flanking IDRs,True,assigned_too_few_test_positives +14277,87697,18.022015,0.8911133,Knottin,keyword,87413,Disulfide bond,0.87841797,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9593015190400223,0.16563408318749262,0.017279574656623838,,9.58554168600438,0.0,17.0,0.0,1.0,Secreted peptides and ectodomains,True,assigned_and_evaluated +14278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge RNA scaffold IDRs,False,no_term_above_threshold +14279,36914,17.952684,1.0,Glycosyltransferase 2-like,interpro,87525,Glycosyltransferase,0.8574219,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Conserved GT-A catalytic motifs,True,assigned_too_few_test_positives +14280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-cap/pre-strand boundary residues,False,no_term_above_threshold +14281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-anchor TMs and Zn-PLC,False,no_term_above_threshold +14282,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal PABB helical activation,False,no_term_above_threshold +14283,48767,20.35444,0.96875,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.96875,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,19.0,0.0,1.0,Beta-sandwich edge strands,True,assigned_too_few_test_positives +14284,64155,16.377989,0.97021484,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.96875,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,12.0,16.0,207.98023255813953,2.0249524163038114e-26,Nuclease catalytic motifs,True,assigned_too_few_test_positives +14285,39971,18.27187,0.94628906,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.8989258,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,20.0,0.0,1.0,Flexible domain-edge gating loops,True,assigned_too_few_test_positives +14286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta/coil patches,False,no_term_above_threshold +14287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-forming toxin beta-barrel stem,False,no_term_above_threshold +14288,88161,22.689926,0.6074219,Transmembrane helix,keyword,88161,Transmembrane helix,0.6074219,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.709869930142842,0.4865834252437908,0.1847585290208241,0.44364508393285373,2.6336182032979276,4.0,18.0,1.2061093410205836,0.6697436200581356,Upstream motif border marker,True,assigned_and_evaluated +14289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-solenoid helix-coil junctions,False,no_term_above_threshold +14290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Death-fold/TIR signaling modules,False,no_term_above_threshold +14291,45804,22.369602,0.9951172,Major facilitator superfamily,interpro,88162,Transport,0.6113281,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,17.0,19.0,246.96807992202727,2.241047219998504e-39,MFS juxtamembrane capping helices,True,assigned_too_few_test_positives +14292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich IDRs,False,no_term_above_threshold +14293,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leader detector,False,no_term_above_threshold +14294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain internal helices,False,no_term_above_threshold +14295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pyruvate kinase C-terminal helix,False,no_term_above_threshold +14296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T/P/Q-rich low-complexity IDRs,False,no_term_above_threshold +14297,36886,15.73792,0.92626953,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,49116,Armadillo-type fold,0.82714844,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8627723432636727,0.2923047828273238,0.003544528134692069,0.625,82.46648685515873,0.0,12.0,0.0,1.0,Non-catalytic alpha-helical scaffold,True,assigned_and_evaluated +14298,85649,19.663689,0.90478516,Vaccinia Virus protein VP39,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7675781,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8985345062473239,0.14592978473086274,0.0101905183872397,,14.320153223372051,0.0,14.0,0.0,1.0,Core beta-sheet scaffold residues,True,assigned_and_evaluated +14299,31094,15.882709,0.92041016,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.79248047,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.8975077881619938,0.42167751265914977,0.004430660168365086,0.6,95.1726146071701,0.0,15.0,0.0,1.0,AS-B-like adenylation domain,True,assigned_and_evaluated +14300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic S/T/P-rich linkers,False,no_term_above_threshold +14301,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular Trp-rich disulfide motifs,False,no_term_above_threshold +14302,32555,16.352003,0.79589844,"proton-transporting ATP synthase activity, rotational mechanism",go_mf,32555,"proton-transporting ATP synthase activity, rotational mechanism",0.79589844,70,go,GO:0046933,go_mf:go:GO:0046933,23.0,2257.0,0.9675178077926122,0.2991797388074423,0.0101905183872397,,29.35863784732162,0.0,10.0,0.0,1.0,Elongated coiled-coil dimerization scaffolds,True,assigned_and_evaluated +14303,50806,18.291105,0.99072266,"Homeobox, conserved site",interpro,64146,Winged helix-like DNA-binding domain superfamily,0.94384766,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,Bacterial TF critical residue detector,True,assigned_too_few_test_positives +14304,36977,17.37121,0.9692383,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.8847656,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,10.0,19.0,163.43475877192984,2.2341786607428882e-20,Kinase N-lobe β4–β5 patch,True,assigned_too_few_test_positives +14305,45290,35.354385,0.97216797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97216797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9612813656931304,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Kinase HRD/HxD catalytic loop,True,assigned_and_evaluated +14306,45551,17.116863,0.98828125,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.98828125,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,15.0,0.0,1.0,Helices flanking catalytic acidic motifs,True,assigned_too_few_test_positives +14307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UDG superfamily catalytic groove,False,no_term_above_threshold +14308,31094,18.107277,0.98876953,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.8359375,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9986648865153538,0.8446789321789322,0.004430660168365086,0.8,190.644034992785,9.0,17.0,375.7626050420168,9.22141500893519e-22,PKS/FAS ketosynthase domain,True,assigned_and_evaluated +14309,85762,33.019978,0.95947266,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.94873047,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,15.0,15.0,205.58965517241379,7.110790058883305e-35,Flavoprotein C-terminal capping helix,True,assigned_too_few_test_positives +14310,87882,34.889065,0.85595703,Palmitate,keyword,87882,Palmitate,0.85595703,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9974085591588924,0.7568713450292397,0.002658396101019052,0.8333333333333334,284.70977095516565,20.0,20.0,66.61564245810055,1.5919415596255537e-36,Post-signal-peptide periplasmic segment,True,assigned_and_evaluated +14311,45714,15.760894,0.71191406,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,86137,Helix-loop-helix DNA-binding domain,0.70654297,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,17.0,0.0,1.0,Extracellular disordered loops and linkers,True,assigned_too_few_test_positives +14312,47529,21.040298,0.76220703,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.76220703,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8010095939312806,0.14850542502836384,0.007089056269384138,,20.948546518063573,8.0,20.0,30.931776913099874,1.7453108111974968e-10,Noncatalytic beta-sheet binding modules,True,assigned_and_evaluated +14313,82029,19.29577,0.9970703,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.8613281,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,17.0,188.0788643533123,1.0133225259294918e-38,Multi-pass TM helix signal,True,assigned_too_few_test_positives +14314,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane low-complexity stalks,False,no_term_above_threshold +14315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane bundle,False,no_term_above_threshold +14316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HExxH catalytic helix context,False,no_term_above_threshold +14317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecB-family 4Fe–4S nuclease core,False,no_term_above_threshold +14318,64585,16.211565,0.95458984,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.88183594,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,16.0,0.0,1.0,Extracellular β-solenoid repeats,True,assigned_too_few_test_positives +14319,36535,19.682632,0.9892578,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.98339844,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9978860703159769,0.8577838827838827,0.004430660168365086,0.8,193.60182234432236,15.0,15.0,89.79066265060241,1.585928718533337e-29,Kinase activation segment (T-loop),True,assigned_and_evaluated +14320,87276,32.860176,0.64208984,Cell membrane,keyword,88161,Transmembrane helix,0.6254883,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6825459875354017,0.42500055889265465,0.11120957022596367,0.398406374501992,3.821618571397297,6.0,12.0,4.102738783374622,0.0027314020718276055,Functional transmembrane helices,True,assigned_and_evaluated +14321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPFH/Band-7 early beta-strand,False,no_term_above_threshold +14322,37894,17.15085,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.85498047,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,13.0,13.0,709.7738095238095,2.0554498274794366e-37,Rossmann/SDR N-cap loops,True,assigned_too_few_test_positives +14323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic proline-rich IDRs,False,no_term_above_threshold +14324,45714,17.798,0.9213867,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.9213867,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,11.0,0.0,1.0,Post-signal N-terminal region,True,assigned_too_few_test_positives +14325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-binding catalytic scaffolds,False,no_term_above_threshold +14326,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-induced turns and kinks,False,no_term_above_threshold +14327,85364,26.095778,0.89453125,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.89453125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,20.0,286.06035353535356,1.6581398788288283e-45,PBP/VFT C-terminal hinge,True,assigned_too_few_test_positives +14328,81858,15.687185,0.90185547,Rhodopsin 7-helix transmembrane proteins,gene3d,87484,G-protein coupled receptor,0.8964844,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,17.0,0.0,1.0,Juxtamembrane loops and caps,True,assigned_too_few_test_positives +14329,83419,17.94718,0.9814453,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.96875,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,5.0,18.0,100.98407859078591,2.528930975123766e-09,Extracellular beta-edge loop motifs,True,assigned_too_few_test_positives +14330,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic N-terminal helices,False,no_term_above_threshold +14331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pan-sequence mixed-residue activation,False,no_term_above_threshold +14332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cystatin-like beta-hairpin loop,False,no_term_above_threshold +14333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity disordered tails,False,no_term_above_threshold +14334,38317,18.054548,0.9770508,Pentatricopeptide repeat,interpro,88009,Repeat,0.76660156,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9150158730158731,0.2302992675260828,0.0031014621178555605,,74.25506382948126,1.0,16.0,24.04072580645161,0.06748547065858733,Ankyrin-centric helical repeat detector,True,assigned_and_evaluated +14335,50338,21.733486,0.9194336,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.86572266,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Kinked aromatic transmembrane helices,True,assigned_too_few_test_positives +14336,87390,16.36419,0.76171875,Defensin,keyword,87390,Defensin,0.76171875,37,keywords,Defensin,keyword:keywords:Defensin,,,,,,,,0.0,15.0,0.0,1.0,Secreted β-rich disulfide cores,True,assigned_too_few_test_positives +14337,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NTP/nucleic-acid-binding core,False,no_term_above_threshold +14338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Ser-rich cytoskeletal linkers,False,no_term_above_threshold +14339,64003,16.892202,0.9765625,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.96484375,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9622627520759194,0.051922644320566896,0.003987594151528578,,13.021045359057721,1.0,20.0,6.523085339168491,0.22723392529760902,Zinc fingers and HTH helices,True,assigned_and_evaluated +14340,85672,21.92804,0.62109375,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6142578,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6225361448796839,0.24301436975617302,0.01595037660611431,0.25,15.235650903880071,17.0,17.0,40.01409395973155,1.7557395315514075e-27,Helicase ATPase coupling core,True,assigned_and_evaluated +14341,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycerolipid acyltransferase catalytic core,False,no_term_above_threshold +14342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich disordered scaffolds,False,no_term_above_threshold +14343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad N-terminal activation,False,no_term_above_threshold +14344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid binding/catalytic surfaces,False,no_term_above_threshold +14345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP/PPi-handling active sites,False,no_term_above_threshold +14346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical coupling patches,False,no_term_above_threshold +14347,88153,15.803785,0.6376953,Transferase,keyword,88153,Transferase,0.6376953,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.808644692675948,0.1692841134554201,0.052724856003544526,,3.2107079333519595,5.0,15.0,3.7818585474151596,0.012832486587239546,Conserved internal TG/uL15m motif,True,assigned_and_evaluated +14348,64058,23.735884,0.6796875,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.6796875,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6767562575632127,0.22410081426474868,0.006202924235711121,0.14285714285714285,36.12825269968127,14.0,15.0,106.39821542383683,6.768650703886307e-28,Membrane-tethering terminal amphipathic helices,True,assigned_and_evaluated +14349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extreme C-terminal motif,False,no_term_above_threshold +14350,87384,21.406765,0.6347656,DNA-binding,keyword,87384,DNA-binding,0.6347656,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.6096507241085555,0.07210309005070767,0.043863535666814356,,1.6438047903479516,3.0,19.0,1.9342186367912795,0.3140875346302314,Lys/Arg-rich polybasic patches,True,assigned_and_evaluated +14351,47529,16.124716,0.85058594,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.85058594,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9199994422132975,0.05105644729298153,0.007089056269384138,,7.202150096266208,0.0,17.0,0.0,1.0,Generic beta strand-turn motif,True,assigned_and_evaluated +14352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar helix cap marker,False,no_term_above_threshold +14353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-TM coiled-coil stalks,False,no_term_above_threshold +14354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UbiD-like C-terminal helix–strand,False,no_term_above_threshold +14355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic helical order signal,False,no_term_above_threshold +14356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved TM glycine/polar patches,False,no_term_above_threshold +14357,82029,20.938963,0.92626953,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.64746094,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Juxtamembrane helix caps/hinges,True,assigned_too_few_test_positives +14358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ASCE P-loop ATPase core,False,no_term_above_threshold +14359,69990,17.029577,0.9555664,DNA/RNA polymerase superfamily,interpro,46274,Ribonuclease H-like superfamily,0.796875,80,ip,IPR043502,interpro:ip:IPR043502,7.0,2257.0,0.707047619047619,0.31269663381524515,0.0031014621178555605,0.2857142857142857,100.82232893157261,15.0,18.0,218.87298091042584,1.219644139639429e-33,Polymerase palm catalytic motif,True,assigned_and_evaluated +14360,49116,17.221334,0.7890625,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.7890625,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8906305506216696,0.16065781858453027,0.002215330084182543,,72.52093930905697,16.0,16.0,87.03795620437957,3.1459123761526603e-31,Regulatory low-complexity IDRs,True,assigned_and_evaluated +14361,87882,20.456673,0.7705078,Palmitate,keyword,88058,Signal,0.72558594,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9004146305345774,0.09704652120501571,0.002658396101019052,,36.50566639328674,5.0,18.0,18.504345127250154,1.031309184113659e-05,Surface polar binding patches,True,assigned_and_evaluated +14362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic beta-strand,False,no_term_above_threshold +14363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteasome beta internal helix-strand,False,no_term_above_threshold +14364,45290,23.74229,0.7392578,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7392578,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6087344028520499,0.10358150931921424,0.0057598582188746125,0.07692307692307693,17.983343579497426,17.0,17.0,73.42487684729065,6.829036441178294e-32,Catalytic core buttress helix,True,assigned_and_evaluated +14365,36104,19.162663,0.8120117,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8120117,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Polymerase thumb/palm nucleic acid binding,True,assigned_too_few_test_positives +14366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic DNA-engaging accessory modules,False,no_term_above_threshold +14367,64026,15.900007,0.73046875,MFS transporter superfamily,interpro,30856,transmembrane transporter activity,0.7270508,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.7419665333925662,0.0668053885267,0.002658396101019052,,25.129960317460313,0.0,18.0,0.0,1.0,Transporter C-terminal TM helix-loop hinges,True,assigned_and_evaluated +14368,36951,18.867737,0.8330078,SET domain,interpro,63831,F-box-like domain superfamily,0.7895508,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,20.0,0.0,1.0,N-terminal periplasmic gating domains,True,assigned_too_few_test_positives +14369,63831,20.166153,0.9243164,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9243164,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.910891455649341,0.016631083122406284,0.002658396101019052,,6.2560591012118305,0.0,17.0,0.0,1.0,Interhelical glycine-centered turns,True,assigned_and_evaluated +14370,25169,15.622837,0.85253906,pilus,go_cc,25169,pilus,0.85253906,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8869449378330374,0.06864840370746833,0.002215330084182543,,30.987889433551207,0.0,18.0,0.0,1.0,Repeated β-strand capping loops,True,assigned_and_evaluated +14371,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid transfer groove lining segments,False,no_term_above_threshold +14372,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic accessory flanking regions,False,no_term_above_threshold +14373,85364,21.57546,0.95703125,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.95703125,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,16.0,19.0,253.57150451887293,6.842393173280208e-37,Extracellular/periplasmic ligand-binding helices,True,assigned_too_few_test_positives +14374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal signal-anchor helix,False,no_term_above_threshold +14375,45551,16.207355,0.9160156,SKP1/BTB/POZ domain superfamily,interpro,46274,Ribonuclease H-like superfamily,0.8613281,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,19.0,0.0,1.0,Interdomain gating hinges,True,assigned_too_few_test_positives +14376,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS N-cap coupling loop,False,no_term_above_threshold +14377,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cysteine-centered motif signal,False,no_term_above_threshold +14378,87317,23.05364,0.84716797,Cleavage on pair of basic residues,keyword,88058,Signal,0.62402344,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.9495760821062026,0.1592326008062016,0.007089056269384138,,22.461748751224814,0.0,19.0,0.0,1.0,Secreted low-complexity disordered regions,True,assigned_and_evaluated +14379,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity repeats,False,no_term_above_threshold +14380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessible loop binding hotspots,False,no_term_above_threshold +14381,39971,24.244081,0.9995117,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,13.0,15.0,574.1281481481482,4.6331072063227474e-35,Metal-dependent phosphoesterase core,True,assigned_too_few_test_positives +14382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,uL18 LDxGL motif,False,no_term_above_threshold +14383,87852,18.26696,0.90283203,Nucleosome core,keyword,87852,Nucleosome core,0.90283203,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,19.0,0.0,1.0,RS/arginine-rich low-complexity IDRs,True,assigned_too_few_test_positives +14384,48767,15.5733795,0.98876953,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.90771484,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,14.0,0.0,1.0,Acidic β-strand exit caps,True,assigned_too_few_test_positives +14385,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adjacent recognition/assembly subdomains,False,no_term_above_threshold +14386,45290,31.380672,0.9707031,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.9707031,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9606643356643356,0.9235199890937593,0.0057598582188746125,0.9230769230769231,160.33727810650882,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase αC-β4 loop motif,True,assigned_and_evaluated +14387,45290,31.15489,0.97021484,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97021484,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9608871520636227,0.9235199890937595,0.0057598582188746125,0.9230769230769231,160.33727810650888,19.0,19.0,73.42487684729065,1.537287712313484e-35,Kinase HRD-DFG segment,True,assigned_and_evaluated +14388,31094,15.731751,0.9941406,phosphopantetheine binding,go_mf,36668,AMP-dependent synthetase/ligase domain,0.9345703,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9996439697374276,0.9105880230880231,0.004430660168365086,1.0,205.51971681096683,9.0,17.0,375.7626050420168,9.22141500893519e-22,Active-site lids and pore gates,True,assigned_and_evaluated +14389,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal CBM-like β-sandwich,False,no_term_above_threshold +14390,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane pore-forming barrels,False,no_term_above_threshold +14391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +14392,85656,24.340916,0.7055664,alpha/beta hydrolase,gene3d,85656,alpha/beta hydrolase,0.7055664,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.852952380952381,0.4870052760475539,0.0031014621178555605,0.42857142857142855,157.02441543418988,18.0,18.0,141.281990521327,9.999057839062593e-39,Noncatalytic hydrolase cap/propeller segments,True,assigned_and_evaluated +14393,47717,16.973335,0.97753906,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.66552734,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,16.0,17.0,257.4031300593632,6.636301916524782e-38,SF2 helicase motif VI,True,assigned_too_few_test_positives +14394,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leu-rich hydrophobic alpha-helices,False,no_term_above_threshold +14395,50338,18.049698,0.89160156,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.81640625,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,PAS domain signaling helices,True,assigned_too_few_test_positives +14396,36104,18.566132,0.95996094,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.95996094,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Conserved core and acidic activation,True,assigned_too_few_test_positives +14397,85664,15.931838,0.73535156,Glycogen Phosphorylase B;,gene3d,85649,Vaccinia Virus protein VP39,0.7285156,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,16.0,0.0,1.0,Rossmann SAM-binding pocket,True,assigned_too_few_test_positives +14398,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding catalytic pockets,False,no_term_above_threshold +14399,87239,16.648628,0.7836914,CF(1),keyword,85682,NAD(P)-binding Rossmann-like Domain,0.65771484,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9975637013857845,0.6076781896910616,0.008861320336730172,1.0,68.57648370663631,0.0,14.0,0.0,1.0,NAD lid terminal helix,True,assigned_and_evaluated +14400,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular proteases and CUB/EGF repeats,False,no_term_above_threshold +14401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic interfacial helix caps,False,no_term_above_threshold +14402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HTH/WH nucleic acid recognition helices,False,no_term_above_threshold +14403,85672,19.445614,0.61572266,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.61572266,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6454612536895292,0.2375848606689604,0.01595037660611431,0.25,14.895250848051212,12.0,12.0,40.01409395973155,1.4584552891973136e-19,ABC NBD helix-loop hinge,True,assigned_and_evaluated +14404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix C-terminal boundary,False,no_term_above_threshold +14405,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AlaX-like acyl-hydrolase core,False,no_term_above_threshold +14406,64148,17.037922,0.67333984,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.67333984,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.6223837072574196,0.05350767805574507,0.008418254319893664,,6.3561489143061385,0.0,16.0,0.0,1.0,PAS N-cap helix hotspots,True,assigned_and_evaluated +14407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal extracellular ectodomains,False,no_term_above_threshold +14408,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-helix and charged coiled-coil,False,no_term_above_threshold +14409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site surface patches,False,no_term_above_threshold +14410,88263,17.617546,0.6357422,Zinc-finger,keyword,88263,Zinc-finger,0.6357422,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.6686968606932635,0.0938806079319695,0.014621178555604785,0.06060606060606061,6.420864609165308,14.0,18.0,20.267433954933953,9.252350436238972e-17,RBR ligase helical extensions,True,assigned_and_evaluated +14411,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity tandem repeats,False,no_term_above_threshold +14412,37097,23.614603,0.87060547,Cro/C1-type helix-turn-helix domain,interpro,37097,Cro/C1-type helix-turn-helix domain,0.87060547,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,14.0,16.0,492.15448113207543,9.190988678163333e-37,Interfacial helices and anchors,True,assigned_too_few_test_positives +14413,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gram-positive extracellular domains,False,no_term_above_threshold +14414,36104,16.778727,0.9995117,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9995117,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Short helical recognition elements,True,assigned_too_few_test_positives +14415,36499,28.78558,0.89697266,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.89697266,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,13.0,0.0,1.0,N-terminal nucleotide/phosphate-binding module,True,assigned_too_few_test_positives +14416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FHA/forkhead C-terminal linkers,False,no_term_above_threshold +14417,85675,17.777794,0.95166016,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.92871094,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,18.0,19.0,518.1931434089811,9.602462486774284e-48,N-terminal VWA MIDAS motif,True,assigned_too_few_test_positives +14418,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase nucleic acid interface,False,no_term_above_threshold +14419,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate-gating cap helix,False,no_term_above_threshold +14420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal motifs and interface hotspots,False,no_term_above_threshold +14421,85682,18.466831,0.88671875,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.88671875,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9731899641577061,0.29163585450918506,0.011076650420912717,0.44,26.328884945089225,9.0,18.0,51.13293310463121,7.881327298615834e-14,Rossmann cofactor pocket flanks,True,assigned_and_evaluated +14422,36552,18.119946,0.93310547,EGF-like domain,interpro,82716,Laminin,0.9086914,57,ip,IPR000742,interpro:ip:IPR000742,5.0,2257.0,0.999733570159858,0.9028571428571428,0.002215330084182543,1.0,407.5497142857143,0.0,16.0,0.0,1.0,Extracellular glycine-rich Ca2+ loops,True,assigned_and_evaluated +14423,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane efflux channel C-terminus,False,no_term_above_threshold +14424,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-to-α interface microelement,False,no_term_above_threshold +14425,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic beta-sandwich cores,False,no_term_above_threshold +14426,48241,21.658262,0.9819336,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9819336,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,18.0,18.0,387.14935064935065,2.6960306916448084e-46,Jelly-roll β-hairpin cap,True,assigned_too_few_test_positives +14427,63951,17.110361,0.97802734,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.94140625,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9984677738236457,0.6913931321977298,0.003987594151528578,0.8888888888888888,173.38603326336403,18.0,19.0,152.65689900426742,1.6359638213673626e-38,Ig/FN3 loop interface residues,True,assigned_and_evaluated +14428,37468,20.536839,0.9199219,"Zinc finger, RING-type",interpro,37468,"Zinc finger, RING-type",0.9199219,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,15.0,19.0,108.45440213436818,8.895756262638816e-29,RING E3 disordered linkers,True,assigned_too_few_test_positives +14429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site helical scaffolds,False,no_term_above_threshold +14430,38317,20.90373,1.0,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9316406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9998095238095238,0.9379251700680271,0.0031014621178555605,1.0,302.4138726919339,20.0,20.0,384.6516129032258,7.999014609586429e-51,Helical repeat core register,True,assigned_and_evaluated +14431,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich disordered motifs,False,no_term_above_threshold +14432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protein interaction scaffold regions,False,no_term_above_threshold +14433,72011,16.7504,0.9667969,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.92822266,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,6.0,0.0,1.0,ABC ATPase switch loops,True,assigned_too_few_test_positives +14434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Function-critical long alpha helix,False,no_term_above_threshold +14435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartyl protease fold detector,False,no_term_above_threshold +14436,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar/charged disordered flanks,False,no_term_above_threshold +14437,63831,17.478815,0.91064453,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.91064453,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8080482748408114,0.00754574450523402,0.002658396101019052,,2.838457558052197,0.0,13.0,0.0,1.0,Alpha-helix N-cap residues,True,assigned_and_evaluated +14438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T/P-rich disordered tails,False,no_term_above_threshold +14439,64058,26.060537,0.9560547,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9477539,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9829787911597987,0.1745738792644312,0.006202924235711121,,28.143803249987226,1.0,18.0,6.333227108561716,0.2335014920738494,Rossmann β2 acidic-cap motif,True,assigned_and_evaluated +14440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WWE domain ADP-ribose reader,False,no_term_above_threshold +14441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent exposed assembly segments,False,no_term_above_threshold +14442,50806,18.862764,0.8046875,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.8046875,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,10.0,0.0,1.0,Acidic disordered sigma linker,True,assigned_too_few_test_positives +14443,87108,25.447903,0.9301758,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.92529297,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8790529853697113,0.3546786717651582,0.003987594151528578,0.4444444444444444,88.94552913044024,11.0,20.0,93.1578125,1.072132520874404e-19,Helical ankyrin repeat arrays,True,assigned_and_evaluated +14444,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal hydrophobic assembly anchors,False,no_term_above_threshold +14445,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic DNA-recognition surfaces,False,no_term_above_threshold +14446,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain start interaction hotspots,False,no_term_above_threshold +14447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure capping residues,False,no_term_above_threshold +14448,25167,16.64791,0.6640625,cell outer membrane,go_cc,25167,cell outer membrane,0.6640625,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.910913140311804,0.32066610910854176,0.005316792202038104,0.16666666666666666,60.31195068816489,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer-membrane beta-barrel strands,True,assigned_and_evaluated +14449,59211,33.49607,0.9506836,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9506836,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.9994982078853046,0.9118879674440314,0.011076650420912717,1.0,82.32524570084715,10.0,14.0,174.53454332552695,2.9036718635199726e-21,Glycosyltransferase C-terminal catalytic lobe,True,assigned_and_evaluated +14450,49045,18.058731,0.99853516,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9658203,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,8.0,20.0,216.80363636363637,3.128284849962098e-17,Beta-propeller blade-capping loops,True,assigned_too_few_test_positives +14451,47529,17.472712,0.77441406,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.77441406,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.823516287371709,0.14618312946808706,0.007089056269384138,,20.620957700592033,5.0,18.0,21.480400634097133,5.05021125919818e-06,Surface-exposed extracellular ectodomains,True,assigned_and_evaluated +14452,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Actinoporin/aerolysin beta-pore cytolysins,False,no_term_above_threshold +14453,36104,22.466507,0.9741211,Rho GTPase-activating protein domain,interpro,4066,type II site-specific deoxyribonuclease,0.85791016,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,20.0,0.0,1.0,Catalytic domain activation across enzymes,True,assigned_too_few_test_positives +14454,36914,20.469967,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Aromatic sugar-donor clamp motif,True,assigned_too_few_test_positives +14455,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal helix in Sec-exported proteins,False,no_term_above_threshold +14456,87326,35.09577,0.70166016,Coiled coil,keyword,87326,Coiled coil,0.70166016,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7115111530328787,0.1882846692062045,0.03943287549844927,0.19101123595505617,4.774814588746108,10.0,18.0,7.004182232560326,4.5957150021109826e-07,Non-transmembrane coiled-coil scaffolds,True,assigned_and_evaluated +14457,87276,44.51165,0.78759766,Cell membrane,keyword,88161,Transmembrane helix,0.77246094,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.868256783434557,0.6891288561031156,0.11120957022596367,0.7370517928286853,6.196668638345545,10.0,16.0,5.128423479218277,5.4065778119213196e-06,TM helix caps and linkers,True,assigned_and_evaluated +14458,87951,16.95004,0.8754883,Prenylation,keyword,87951,Prenylation,0.8754883,31,keywords,Prenylation,keyword:keywords:Prenylation,,,,,,,,7.0,8.0,457.6173245614035,1.5472198493069111e-18,TRAFAC small GTPase signature,True,assigned_too_few_test_positives +14459,81799,17.12934,0.98046875,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6879883,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,10.0,12.0,482.3705501618123,3.148521085966243e-26,AAA+ sensor-2 lid helix,True,assigned_too_few_test_positives +14460,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IlvB-like xLVxxAK(K/R)P loop,False,no_term_above_threshold +14461,88009,15.592251,0.61035156,Repeat,keyword,88009,Repeat,0.61035156,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6086723456818897,0.12475908536418415,0.07266282676118742,,1.7169588760180707,13.0,20.0,5.762624535315985,3.390409932462349e-08,Asn/Ser/Thr-rich disordered repeats,True,assigned_and_evaluated +14462,81540,15.594842,0.9975586,"Tetracycline Repressor, domain 2",gene3d,81540,"Tetracycline Repressor, domain 2",0.9975586,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,20.0,20.0,828.0694444444445,2.4307463492151184e-57,C-terminal amphipathic dimerization helix,True,assigned_too_few_test_positives +14463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal WD40/transmembrane regions,False,no_term_above_threshold +14464,37446,16.11516,0.8642578,F-box domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.75683594,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.6854285714285713,0.005321925122713236,0.0031014621178555605,,1.7159407145662535,0.0,16.0,0.0,1.0,Helix-start N-cap residues,True,assigned_and_evaluated +14465,82597,25.238064,0.97216797,Tetratricopeptide repeat domain,gene3d,46079,Tetratricopeptide-like helical domain superfamily,0.9707031,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9901103798162622,0.23369041123383555,0.0057598582188746125,,40.572250627289755,4.0,15.0,25.978649237472766,2.5527425196085048e-05,HEAT/TPR/SEL1 alpha-solenoids,True,assigned_and_evaluated +14466,48241,24.257185,0.94189453,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.94189453,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,11.0,11.0,387.14935064935065,8.37326949129388e-29,Cupin DSBH jelly-roll scaffold,True,assigned_too_few_test_positives +14467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane interfacial gating segments,False,no_term_above_threshold +14468,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +14469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UvrD-family helicase ATPase segment,False,no_term_above_threshold +14470,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs flanking DBDs,False,no_term_above_threshold +14471,85656,19.431364,0.9399414,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.89404297,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9513650793650794,0.03917465197561824,0.0031014621178555605,,12.63102707271005,0.0,15.0,0.0,1.0,Hydrophobic beta-sheet core,True,assigned_and_evaluated +14472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved glycine beta-sheet site,False,no_term_above_threshold +14473,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV sensory regulatory domains,False,no_term_above_threshold +14474,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ssRNA-binding S1/OB/KH domains,False,no_term_above_threshold +14475,45290,33.643337,0.97216797,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97216797,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9610756890168655,0.9235199890937597,0.0057598582188746125,0.9230769230769231,160.33727810650888,16.0,16.0,73.42487684729065,4.583656533651311e-30,Kinase N-lobe HxN motif,True,assigned_and_evaluated +14476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proteostasis Ser/Pro-rich regulatory IDRs,False,no_term_above_threshold +14477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electropositive polyanion-binding channels,False,no_term_above_threshold +14478,50338,18.370932,0.875,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.875,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,15.0,0.0,1.0,Aromatic TM helix–turn motifs,True,assigned_too_few_test_positives +14479,36876,16.761837,0.9057617,Cytochrome P450,interpro,36876,Cytochrome P450,0.9057617,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9947607750098854,0.3725983467362778,0.003987594151528578,0.4444444444444444,93.43938539819767,0.0,19.0,0.0,1.0,Tyrosine recombinase core-binding domain,True,assigned_and_evaluated +14480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bacterial ectodomain strand/helix patches,False,no_term_above_threshold +14481,45714,19.4551,0.99316406,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.98046875,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,16.0,0.0,1.0,Histidine kinase DHp helix,True,assigned_too_few_test_positives +14482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular binding loops,False,no_term_above_threshold +14483,64058,22.18759,0.6567383,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.6567383,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6405006050570027,0.1984782792159841,0.006202924235711121,0.2857142857142857,31.997534013605435,10.0,10.0,113.99808795411089,6.6006111873174026e-21,Rossmann-like adenosine cofactor-binding core,True,assigned_and_evaluated +14484,36010,20.970629,0.9506836,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.921875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,14.0,0.0,1.0,Post-signal peptide N-cap,True,assigned_too_few_test_positives +14485,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended noncatalytic structural regions,False,no_term_above_threshold +14486,72011,20.861954,0.9658203,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.8935547,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,10.0,10.0,590.3069306930694,4.195166035704531e-28,NRPS adenylation domain signature,True,assigned_too_few_test_positives +14487,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble scaffolds with disordered tails,False,no_term_above_threshold +14488,85664,26.048756,0.9423828,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9423828,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,10.0,14.0,236.59126984126985,1.3448720848703805e-22,Nucleotide-sugar binding signature,True,assigned_too_few_test_positives +14489,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic conserved helical motif,False,no_term_above_threshold +14490,88161,52.871197,0.6591797,Transmembrane helix,keyword,88161,Transmembrane helix,0.6591797,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.722641669273277,0.5353648455187234,0.1847585290208241,0.5179856115107914,2.897646178263211,16.0,16.0,5.4274920345926265,3.815160537588821e-12,C-terminal cytosolic juxtamembrane helix,True,assigned_and_evaluated +14491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane helices,False,no_term_above_threshold +14492,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Protease zymogen prodomains,False,no_term_above_threshold +14493,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic helical runs,False,no_term_above_threshold +14494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site proximal motif,False,no_term_above_threshold +14495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosylated extracellular linkers with stickers,False,no_term_above_threshold +14496,46277,29.07948,0.9794922,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.9794922,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.9975714401359994,0.6125785578058306,0.004873726185201595,0.9090909090909091,125.68998226979635,7.0,17.0,77.4442382631286,4.552757365375542e-12,Beta-loop nucleic acid interfaces,True,assigned_and_evaluated +14497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal regulatory segments,False,no_term_above_threshold +14498,85656,17.544636,0.9355469,alpha/beta hydrolase,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.8198242,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9566984126984127,0.04398948759031235,0.0031014621178555605,,14.18346764161928,1.0,18.0,7.848999473407056,0.19288573788380464,Helix-strand capping turns,True,assigned_and_evaluated +14499,25167,17.69078,0.76220703,cell outer membrane,go_cc,25167,cell outer membrane,0.76220703,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9537119524870081,0.7857872833463481,0.005316792202038104,0.8333333333333334,147.79349154272563,10.0,17.0,80.25440839951541,1.841978180000265e-17,Outer-membrane β-barrel strands,True,assigned_and_evaluated +14500,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH catalytic cleft scaffold,False,no_term_above_threshold +14501,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic core substrate-binding region,False,no_term_above_threshold +14502,87586,15.642568,0.6503906,Host membrane,keyword,87586,Host membrane,0.6503906,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.7625700024348673,0.13098009082787118,0.01639344262295082,,7.989785540500142,0.0,12.0,0.0,1.0,Juxtamembrane tails and helices,True,assigned_and_evaluated +14503,88009,29.980228,0.71972656,Repeat,keyword,88009,Repeat,0.71972656,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.8840385489378066,0.5158660040243551,0.07266282676118742,0.4268292682926829,7.099448604164448,15.0,18.0,7.387980173482032,7.621985353377785e-12,Structured-domain aromatic hotspot detector,True,assigned_and_evaluated +14504,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal core-entry segment,False,no_term_above_threshold +14505,39971,17.803814,0.9975586,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.98339844,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,15.0,0.0,1.0,Metallo-hydrolase strand/loop signature,True,assigned_too_few_test_positives +14506,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass membrane helix-loop interfaces,False,no_term_above_threshold +14507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic protease flanking regions,False,no_term_above_threshold +14508,64058,17.321043,0.82666016,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8208008,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9470256671549583,0.2804576492309515,0.006202924235711121,0.5714285714285714,45.213779593875536,0.0,16.0,0.0,1.0,ThDP-binding active-site loop,True,assigned_and_evaluated +14509,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclic-nucleotide enzyme boundary linkers,False,no_term_above_threshold +14510,49045,19.280401,1.0,Kelch-type beta propeller,interpro,63831,F-box-like domain superfamily,0.78759766,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,19.0,19.0,542.0090909090909,4.3313349653425253e-51,Propeller blade edge beta-strands,True,assigned_too_few_test_positives +14511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved active-site/interface residues,False,no_term_above_threshold +14512,25325,24.577887,0.6035156,membrane,go_cc,88161,Transmembrane helix,0.60009766,1709,go,GO:0016020,go_cc:go:GO:0016020,108.0,2257.0,0.5994347069265636,0.12563236160489108,0.047851129818342934,0.12037037037037036,2.625483705020733,6.0,18.0,3.128233380555118,0.014903132102987712,Endomembrane multipass TM loops,True,assigned_and_evaluated +14513,39177,16.544626,0.94140625,Fibronectin type III,interpro,47529,Immunoglobulin-like fold,0.828125,39,ip,IPR003961,interpro:ip:IPR003961,,,,,,,,0.0,15.0,0.0,1.0,Aromatic beta edge motif,True,assigned_too_few_test_positives +14514,45290,30.874887,0.96484375,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.96484375,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9606643356643357,0.8831936487674192,0.0057598582188746125,0.9230769230769231,153.3360050206204,12.0,20.0,44.05492610837439,1.0567627659651729e-17,Kinase catalytic activation segment,True,assigned_and_evaluated +14515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-enriched gating loops,False,no_term_above_threshold +14516,8078,16.175951,0.8051758,double-strand break repair,go_bp,8078,double-strand break repair,0.8051758,56,go,GO:0006302,go_bp:go:GO:0006302,5.0,2257.0,0.6903197158081704,0.029760570599529135,0.002215330084182543,,13.433921568627452,2.0,12.0,36.93990086741016,0.002271869143911705,Accessory N-terminal alpha/beta interaction module,True,assigned_and_evaluated +14517,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-sequence helix-end/tail detector,False,no_term_above_threshold +14518,87873,16.852884,0.66503906,Oxidoreductase,keyword,87601,Hydrolase,0.63378906,537,keywords,Oxidoreductase,keyword:keywords:Oxidoreductase,48.0,2257.0,0.6626867360796742,0.15789025107046334,0.021267168808152416,0.1875,7.424131180542411,0.0,16.0,0.0,1.0,Alpha-helices near catalytic motifs,True,assigned_and_evaluated +14519,50338,17.65482,0.99853516,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.97265625,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,15.0,15.0,392.24342105263156,4.6846028532927467e-39,GPCR ICL3–TM6 effector interface,True,assigned_too_few_test_positives +14520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal low-complexity IDR tails,False,no_term_above_threshold +14521,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helices and catalytic residues,False,no_term_above_threshold +14522,36776,19.726437,0.99609375,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.9760742,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9992595883311121,0.6825757575757576,0.002658396101019052,1.0,256.7622474747475,0.0,17.0,0.0,1.0,Recognition helix hydrophobic face,True,assigned_and_evaluated +14523,66234,23.34743,0.92285156,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.92285156,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,9.0,9.0,236.59126984126982,1.01430172921615e-21,Cysteine protease substrate-binding cleft,True,assigned_too_few_test_positives +14524,87697,18.571554,0.84521484,Knottin,keyword,88038,Secreted,0.62841797,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9849656655337449,0.34596457015240145,0.017279574656623838,,20.02159063676846,1.0,20.0,12.631567796610172,0.12435614966478416,Mature secreted bioactive peptide,True,assigned_and_evaluated +14525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble lumenal/extracellular/periplasmic ectodomains,False,no_term_above_threshold +14526,85364,27.645874,0.87060547,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.87060547,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,17.0,301.1161616161616,4.0879330105973736e-42,Early mature-domain N-terminal segment,True,assigned_too_few_test_positives +14527,63831,17.248356,0.93115234,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.93115234,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8900858877535909,0.03904757901267448,0.002658396101019052,,14.68839763860105,0.0,18.0,0.0,1.0,N-terminal alpha-helix detector,True,assigned_and_evaluated +14528,87326,33.507565,0.7192383,Coiled coil,keyword,87326,Coiled coil,0.7192383,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7776156764376633,0.35519908341679807,0.03943287549844927,0.42696629213483145,9.007689115412509,14.0,17.0,10.382670132971775,4.623589871267067e-13,Alpha-helical interface stripes,True,assigned_and_evaluated +14529,61392,19.716719,0.95751953,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.95751953,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9997460317460317,0.9367346938775509,0.0031014621178555605,1.0,302.0300291545189,19.0,19.0,167.4747191011236,3.9106228067767924e-42,Intrinsically disordered low-complexity regions,True,assigned_and_evaluated +14530,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal coupling region,False,no_term_above_threshold +14531,87276,30.989773,0.625,Cell membrane,keyword,88161,Transmembrane helix,0.60546875,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.6714090795343055,0.3238641696763945,0.11120957022596367,0.38645418326693226,2.9121969360941127,8.0,19.0,3.4549379228417862,0.0018450570866947091,Single activated TM helix,True,assigned_and_evaluated +14532,85656,17.08929,0.92041016,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7729492,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9314285714285715,0.037539504188626935,0.0031014621178555605,,12.103808707675856,1.0,15.0,9.418799368088466,0.16347652490170986,Active site helix caps,True,assigned_and_evaluated +14533,82029,29.8678,0.99853516,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9897461,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,17.0,18.0,177.63003855590605,1.6092173338574968e-37,TM1/TM7 extracellular-gate helices,True,assigned_too_few_test_positives +14534,88058,20.882877,0.6298828,Signal,keyword,88058,Signal,0.6298828,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6331933747686422,0.11251095010363389,0.09127159946832078,,1.2327049241936976,5.0,20.0,1.801238670694864,0.21355299572385222,Unknown generic feature,True,assigned_and_evaluated +14535,82029,23.233507,0.98876953,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.6118164,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,2.0,17.0,22.126925218036742,0.00627344140236555,Transmembrane helix–loop boundary residues,True,assigned_too_few_test_positives +14536,28225,16.90955,0.82421875,metalloendopeptidase activity,go_mf,87770,Metalloprotease,0.7089844,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,10.0,19.0,160.09935553168637,2.7534509961534764e-20,Zinc metalloenzyme active-site scaffold,True,assigned_too_few_test_positives +14537,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-rich disordered low-complexity tails,False,no_term_above_threshold +14538,36914,21.460928,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.97802734,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,Glycosyltransferase metal-binding DXD loop,True,assigned_too_few_test_positives +14539,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble cytosolic N-terminal domains,False,no_term_above_threshold +14540,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic domain core activation,False,no_term_above_threshold +14541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helix cap/kink signal,False,no_term_above_threshold +14542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,bHLH helix-1 amphipathic segment,False,no_term_above_threshold +14543,38873,21.49317,0.96435547,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.77978516,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9984014209591475,0.6496503496503496,0.002215330084182543,0.6,293.25216783216786,10.0,10.0,171.32471264367817,1.12424031081604e-22,ABC NBD signature/switch helices,True,assigned_and_evaluated +14544,25169,20.9797,0.91845703,pilus,go_cc,87465,Fimbrium,0.91503906,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7919182948490232,0.28037331152085254,0.002215330084182543,0.4,126.56051282051284,16.0,19.0,464.8810916179337,4.0804486740185507e-41,Short polar/proline-rich extracytoplasmic motifs,True,assigned_and_evaluated +14545,72011,16.811071,0.98046875,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.91748047,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,1.0,14.0,42.16478076379067,0.03934174341256461,Cryptochrome/photolyase FAD-binding bundle signature,True,assigned_too_few_test_positives +14546,52236,25.469032,0.96875,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.94433594,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,2.0,17.0,26.270544172725266,0.004506041755684205,TPR/Sel1 repeat boundary coils,True,assigned_too_few_test_positives +14547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic proline-rich disordered regions,False,no_term_above_threshold +14548,49236,27.173891,0.9042969,C-type lectin fold,interpro,49236,C-type lectin fold,0.9042969,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9980461811722913,0.505,0.002215330084182543,0.2,227.95700000000002,5.0,15.0,180.66969696969696,1.219887648876518e-10,Gly–aromatic surface recognition loops,True,assigned_and_evaluated +14549,36104,15.909854,0.98583984,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.98583984,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Receptor transmembrane helix bundle,True,assigned_too_few_test_positives +14550,50338,15.63577,0.90527344,"GPCR, rhodopsin-like, 7TM",interpro,82029,MFS general substrate transporter like domains,0.87939453,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,7.0,0.0,1.0,Perimembrane acidic catalytic motifs,True,assigned_too_few_test_positives +14551,36010,16.00455,0.99658203,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9711914,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,19.0,19.0,509.58119658119665,1.0715363186979988e-50,Alpha/beta-hydrolase beta1-alpha1 N-cap motif,True,assigned_too_few_test_positives +14552,36354,29.778902,0.8925781,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.8696289,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,17.0,0.0,1.0,PAS/LOV-HAMP interface marker,True,assigned_too_few_test_positives +14553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged catalytic and scaffold domains,False,no_term_above_threshold +14554,63831,19.369062,0.95214844,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.95214844,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8691692581075077,0.011145957014906966,0.002658396101019052,,4.192737497107504,0.0,17.0,0.0,1.0,Secondary-structure capping residues,True,assigned_and_evaluated +14555,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrel translocators,False,no_term_above_threshold +14556,38317,19.115648,0.97265625,Pentatricopeptide repeat,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7661133,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9635873015873015,0.045608863233807945,0.0031014621178555605,,14.70560061695779,0.0,15.0,0.0,1.0,Kinase-domain hydrophobic core,True,assigned_and_evaluated +14557,88038,25.138645,0.60009766,Secreted,keyword,88038,Secreted,0.60009766,3652,keywords,Secreted,keyword:keywords:Secreted,297.0,2257.0,0.5779564350992923,0.19729031277888348,0.13159060700044306,0.18518518518518517,1.4992735216900337,2.0,12.0,1.3381138342759673,0.7025101910195363,Secreted repetitive and cysteine-rich modules,True,assigned_and_evaluated +14558,47531,15.701699,0.89404297,Aldolase-type TIM barrel,interpro,47531,Aldolase-type TIM barrel,0.89404297,52,ip,IPR013785,interpro:ip:IPR013785,,,,,,,,9.0,19.0,119.66748438893845,4.4519041436622594e-17,Conserved radical SAM barrel scaffold,True,assigned_too_few_test_positives +14559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site beta-alpha loop motif,False,no_term_above_threshold +14560,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal structural activation,False,no_term_above_threshold +14561,47529,23.433401,0.9794922,Immunoglobulin-like fold,interpro,88058,Signal,0.6113281,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9865573404730031,0.30198941316665145,0.007089056269384138,0.0625,42.59938159482077,13.0,20.0,50.264137483787295,4.7446120074508906e-20,Solvent-exposed beta-strand loops,True,assigned_and_evaluated +14562,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic amphipathic alpha-helical adaptors,False,no_term_above_threshold +14563,64058,22.541887,0.96240234,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78759766,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9924686325711738,0.3614260419887019,0.006202924235711121,0.35714285714285715,58.26704119775001,1.0,16.0,7.12488049713193,0.21028084137787656,Nucleotide-binding Rossmann-like and GT-B cores,True,assigned_and_evaluated +14564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Low-complexity coiled-coils, anchoring tails",False,no_term_above_threshold +14565,49045,17.485903,0.99853516,Kelch-type beta propeller,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.96191406,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,1.0,17.0,31.88288770053476,0.051406529928619826,Beta-propeller entry strands,True,assigned_too_few_test_positives +14566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic helical dimerization regions,False,no_term_above_threshold +14567,87276,42.473488,0.6948242,Cell membrane,keyword,88161,Transmembrane helix,0.6850586,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7790989581057624,0.519336984876699,0.11120957022596367,0.6055776892430279,4.669894720584501,10.0,19.0,4.318672403552233,4.3047937797857006e-05,Perimembrane loop-helix junctions,True,assigned_and_evaluated +14568,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Short secreted peptides, dispersed activation",False,no_term_above_threshold +14569,69819,31.424541,0.9667969,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.9326172,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,15.0,15.0,419.86619718309856,1.6608451341010338e-39,Actin/ASKHA NTP-binding detector,True,assigned_too_few_test_positives +14570,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +14571,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sugar and phosphate binding grooves,False,no_term_above_threshold +14572,37468,16.376738,0.8232422,"Zinc finger, RING-type",interpro,88263,Zinc-finger,0.73291016,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,6.0,19.0,43.38176085374727,7.3199060046767354e-09,Disordered zinc-finger flanks,True,assigned_too_few_test_positives +14573,87586,16.337645,0.67529297,Host membrane,keyword,87586,Host membrane,0.67529297,404,keywords,Host membrane,keyword:keywords:Host membrane,37.0,2257.0,0.6992512783053324,0.1376783124677674,0.01639344262295082,,8.39837706053381,0.0,13.0,0.0,1.0,Alpha-helical transmembrane anchors,True,assigned_and_evaluated +14574,36104,18.634495,0.85595703,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.85595703,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Multipass membrane transporters and anchors,True,assigned_too_few_test_positives +14575,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HIT domain RDL loop,False,no_term_above_threshold +14576,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic interaction patches,False,no_term_above_threshold +14577,72011,18.878458,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9604492,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,15.0,16.0,553.4127475247525,1.3674482114940457e-40,ANL adenylation β–loop–α motif,True,assigned_too_few_test_positives +14578,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAC and deformylase core fold,False,no_term_above_threshold +14579,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp C-terminal hinge,False,no_term_above_threshold +14580,69819,23.12237,0.89746094,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8613281,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,Phosphate-binding catalytic core,True,assigned_too_few_test_positives +14581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-flanking helix-loop motifs,False,no_term_above_threshold +14582,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAPS-dependent sulfotransferase domain,False,no_term_above_threshold +14583,37020,19.278444,0.99658203,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9609375,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,15.0,18.0,680.6050228310502,3.6678945125095224e-41,Active-site coupling micro-motif,True,assigned_too_few_test_positives +14584,64026,15.793166,0.69384766,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.69384766,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.580482748408115,0.016104218973071432,0.002658396101019052,,6.05787037037037,0.0,15.0,0.0,1.0,Cytosolic TM helix cap,True,assigned_and_evaluated +14585,36449,16.782242,0.9033203,EamA domain,interpro,36449,EamA domain,0.9033203,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,20.0,0.0,1.0,Outer-membrane β-barrel strands,True,assigned_too_few_test_positives +14586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved intradomain residue clusters,False,no_term_above_threshold +14587,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Focal beta-loop subregion activation,False,no_term_above_threshold +14588,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil and transmembrane helices,False,no_term_above_threshold +14589,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low complexity coiled coil scaffolds,False,no_term_above_threshold +14590,59224,18.484228,0.94091797,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.88427734,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9608253968253967,0.07105280480592395,0.0031014621178555605,,22.909454349567195,1.0,20.0,6.868778801843318,0.21703747417951927,Substrate-contacting catalytic loops,True,assigned_and_evaluated +14591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AIR synthase N-terminal binding loop,False,no_term_above_threshold +14592,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal cofactor-binding catalytic domains,False,no_term_above_threshold +14593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AaRS/ANL catalytic core motif,False,no_term_above_threshold +14594,85672,46.134743,0.94921875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.94091797,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.9236017309520237,0.6683900552771392,0.01595037660611431,0.8055555555555556,41.90434318779176,17.0,17.0,40.01409395973155,1.7557395315514075e-27,Helicase ATPase core motifs,True,assigned_and_evaluated +14595,45553,20.250303,0.95751953,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.9375,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,8.0,17.0,322.49357674104124,8.922937574102106e-19,Nuclease catalytic acid–base clusters,True,assigned_too_few_test_positives +14596,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine hydrolase nucleophile elbow,False,no_term_above_threshold +14597,88153,20.500475,0.7001953,Transferase,keyword,87601,Hydrolase,0.6767578,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8585774815071024,0.21707465999277245,0.052724856003544526,,4.117121912636029,4.0,14.0,3.2415930406415656,0.048967196593994546,IDI conserved core motif,True,assigned_and_evaluated +14598,88164,15.958345,0.72021484,Transposition,keyword,88164,Transposition,0.72021484,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.5951154529307283,0.10177226406734605,0.002215330084182543,0.2,45.94000000000001,0.0,14.0,0.0,1.0,Polymerase and nuclease catalytic cores,True,assigned_and_evaluated +14599,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal anion-binding pockets,False,no_term_above_threshold +14600,36886,25.070608,0.99853516,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.99853516,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.999166296131614,0.6635912698412698,0.003544528134692069,1.0,187.21568700396824,18.0,18.0,233.80784313725488,1.5159322438572416e-42,Latent helix regulatory IDRs,True,assigned_and_evaluated +14601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-family sensory signaling modules,False,no_term_above_threshold +14602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lon N-terminal aromatic hotspots,False,no_term_above_threshold +14603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged amphipathic interaction helices,False,no_term_above_threshold +14604,45324,17.663546,0.9995117,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.9819336,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9973357015985791,0.31272727272727274,0.002215330084182543,,141.16509090909094,15.0,16.0,512.7952981651376,4.266976294111953e-40,Extracellular β-solenoid glycan modules,True,assigned_and_evaluated +14605,85672,17.87285,0.60546875,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6040039,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6494572014608034,0.2529858214967505,0.01595037660611431,0.3055555555555556,15.860805531060162,14.0,15.0,37.346487695749445,1.386098964094126e-21,N-terminal disordered GTPase extensions,True,assigned_and_evaluated +14606,45288,20.229132,1.0,CheY-like superfamily,interpro,85669,3.40.50.2300,0.8984375,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,17.0,19.0,413.52794777641776,4.225511880631101e-43,REC phospho-acceptor microenvironments,True,assigned_too_few_test_positives +14607,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Homeobox N-terminal arm and helices,False,no_term_above_threshold +14608,36668,22.285326,0.9995117,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9995117,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,19.0,19.0,532.3303571428571,5.020084665387621e-51,ANL N-lobe entry helix,True,assigned_too_few_test_positives +14609,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane β-barrel strands,False,no_term_above_threshold +14610,37071,22.50005,0.70654297,Homeodomain,interpro,37071,Homeodomain,0.70654297,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,18.0,0.0,1.0,Polybasic coupling helices/linkers,True,assigned_too_few_test_positives +14611,84152,23.93318,0.8803711,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8803711,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,16.0,16.0,562.4622641509434,5.26194117401153e-44,Amidohydrolase C-terminal subdomain,True,assigned_too_few_test_positives +14612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PhzF-fold catalytic core,False,no_term_above_threshold +14613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic-acid–binding catalytic surface,False,no_term_above_threshold +14614,64585,16.692667,0.96435547,"Zinc finger, CCCH-type superfamily",interpro,88163,Transposable element,0.6899414,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,17.0,0.0,1.0,Double-stranded DNA-binding domains,True,assigned_too_few_test_positives +14615,82029,24.21368,0.99365234,MFS general substrate transporter like domains,gene3d,87276,Cell membrane,0.61572266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,MFS paired helix-start signatures,True,assigned_too_few_test_positives +14616,59229,23.13446,0.9580078,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9580078,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9639562492701724,0.7307268049747538,0.0101905183872397,0.7391304347826086,71.7065390794791,13.0,16.0,86.34948752228163,6.317374179475807e-24,SAM methyltransferase Rossmann motif,True,assigned_and_evaluated +14617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface-exposed beta-loop patches,False,no_term_above_threshold +14618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand loop capping positions,False,no_term_above_threshold +14619,37446,18.947361,0.9819336,F-box domain,interpro,37446,F-box domain,0.9819336,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9882539682539683,0.14853799049486116,0.0031014621178555605,,47.8928920781288,0.0,15.0,0.0,1.0,KRAB EEW Trp motif,True,assigned_and_evaluated +14620,36535,20.207283,0.9165039,Protein kinase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.65966797,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.8944370271473076,0.27444748081561005,0.004430660168365086,,61.94279642008319,0.0,7.0,0.0,1.0,ABC NBD LSGGQ C-loop,True,assigned_and_evaluated +14621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CCT EKIPGG β-strand motif,False,no_term_above_threshold +14622,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SBP C-terminal binding cleft,False,no_term_above_threshold +14623,85364,17.228252,0.9814453,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9814453,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,17.0,20.0,255.94873737373737,3.1365718675403606e-39,Small-molecule pocket liners,True,assigned_too_few_test_positives +14624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chromatin low-complexity linkers and helices,False,no_term_above_threshold +14625,85649,22.711649,0.9550781,Vaccinia Virus protein VP39,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.77685547,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9616305320929508,0.5884817409841752,0.0101905183872397,0.6956521739130435,57.747969104403616,9.0,14.0,71.10906440498277,1.712808137176746e-15,Cofactor-binding catalytic loop motifs,True,assigned_and_evaluated +14626,83267,22.614557,0.9140625,DNA-binding pseudobarrel domain,gene3d,83267,DNA-binding pseudobarrel domain,0.9140625,37,gene3d,2.40.330.10,gene3d:gene3d:2.40.330.10,,,,,,,,0.0,14.0,0.0,1.0,Conserved turn/kink interaction motifs,True,assigned_too_few_test_positives +14627,85664,24.741217,0.9506836,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9506836,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,19.0,19.0,331.22777777777776,1.8534282920924948e-47,UGT N-terminal acceptor lobe,True,assigned_too_few_test_positives +14628,63960,31.044111,0.84716797,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.84716797,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,15.0,15.0,193.57467532467533,1.7387176222033654e-34,Domain-wide flavoenzyme activation,True,assigned_too_few_test_positives +14629,81330,16.086899,0.8808594,DnaJ domain,gene3d,81330,DnaJ domain,0.8808594,27,gene3d,1.10.287.110,gene3d:gene3d:1.10.287.110,,,,,,,,5.0,17.0,199.26804812834226,8.095813756324421e-11,Low-complexity disordered linkers,True,assigned_too_few_test_positives +14630,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Claisen-condensing thiolase-fold core,False,no_term_above_threshold +14631,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FAD-binding β–α–β loop,False,no_term_above_threshold +14632,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S1/KH/OB ssRNA-binding surfaces,False,no_term_above_threshold +14633,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal type II signal-anchor helix,False,no_term_above_threshold +14634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PriL/p58 chain-wide activation,False,no_term_above_threshold +14635,63960,31.895046,0.82666016,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.82666016,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,19.0,19.0,193.57467532467533,3.1320939821269373e-43,Rossmann-like flavin-binding helices,True,assigned_too_few_test_positives +14636,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-core glycine helix,False,no_term_above_threshold +14637,88058,34.261112,0.7109375,Signal,keyword,88058,Signal,0.7109375,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6875772178383265,0.13444846561148988,0.09127159946832078,,1.4730591596365663,3.0,18.0,1.2008257804632427,0.7238242703969795,Signal peptides and disordered termini,True,assigned_and_evaluated +14638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-binding and post-signal N-termini,False,no_term_above_threshold +14639,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic multi-pass TM conduit,False,no_term_above_threshold +14640,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-exposed TM hairpins,False,no_term_above_threshold +14641,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity disordered regions,False,no_term_above_threshold +14642,37020,17.487478,0.9873047,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.84277344,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,18.0,0.0,1.0,REC domain Lys signature,True,assigned_too_few_test_positives +14643,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein N-terminal cytosolic regions,False,no_term_above_threshold +14644,64003,21.680332,0.9975586,Zinc finger C2H2 superfamily,interpro,29166,zinc ion binding,0.84375,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,17.0,17.0,130.4617067833698,4.534127311811392e-36,C2H2 Cys2+2 loop detector,True,assigned_and_evaluated +14645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal appendages and coiled-coils,False,no_term_above_threshold +14646,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short N-terminal leader segment,False,no_term_above_threshold +14647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved RTX GxLxID motif,False,no_term_above_threshold +14648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved short helix/loop patches,False,no_term_above_threshold +14649,88160,19.852585,0.85498047,Transmembrane beta strand,keyword,25167,cell outer membrane,0.69628906,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,17.0,20.0,246.00898058252426,6.146287500115658e-39,Outer-membrane C-terminal beta-signal,True,assigned_too_few_test_positives +14650,87489,17.221745,0.6308594,GPI-anchor,keyword,87489,GPI-anchor,0.6308594,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.7799047619047618,0.12990062662193808,0.0031014621178555605,,41.883673469387745,0.0,19.0,0.0,1.0,Extracellular low-complexity loops,True,assigned_and_evaluated +14651,88263,19.09051,0.72753906,Zinc-finger,keyword,88263,Zinc-finger,0.72753906,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.8383202528885983,0.08973644260801836,0.014621178555604785,,6.1374288171605285,1.0,18.0,1.4476738539238538,0.7842877320195357,Early structured domain core,True,assigned_and_evaluated +14652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic/coiled-coil interface helices,False,no_term_above_threshold +14653,32561,16.293795,0.8515625,"proton-transporting ATPase activity, rotational mechanism",go_mf,32561,"proton-transporting ATPase activity, rotational mechanism",0.8515625,35,go,GO:0046961,go_mf:go:GO:0046961,,,,,,,,7.0,11.0,403.62379110251453,1.5583833520818686e-17,Charged amphipathic coiled-coil stalks,True,assigned_too_few_test_positives +14654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic transporter loop segments,False,no_term_above_threshold +14655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat-based structural scaffolds,False,no_term_above_threshold +14656,47717,21.00543,1.0,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6826172,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,10.0,273.49082568807336,1.0378758421347324e-24,Helicase motif Ib helix,True,assigned_too_few_test_positives +14657,37894,16.731264,0.97753906,Short-chain dehydrogenase/reductase SDR,interpro,81685,Transferase(Phosphotransferase) domain 1,0.91503906,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR active site helices,True,assigned_too_few_test_positives +14658,85656,20.116905,0.96533203,alpha/beta hydrolase,gene3d,59224,Alpha/Beta hydrolase fold,0.96435547,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9697142857142858,0.2179870936391663,0.0031014621178555605,0.14285714285714285,70.28526719194262,8.0,14.0,80.73256601218685,3.916528456829348e-14,Catalytic loop hotspot signal,True,assigned_and_evaluated +14659,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal leaders and hot-dog fold,False,no_term_above_threshold +14660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bimodal IDR and catalytic hotspots,False,no_term_above_threshold +14661,61392,23.006903,1.0,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,1.0,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9994285714285714,0.8083900226757369,0.0031014621178555605,1.0,260.6480401684483,15.0,15.0,167.4747191011236,1.5239103019764629e-33,LRR C-terminal capping helix/turn,True,assigned_and_evaluated +14662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,IMPase-like phosphomonoesterase catalytic core,False,no_term_above_threshold +14663,85364,19.8797,0.79296875,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.79296875,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,9.0,16.0,169.3778409090909,1.148391070211066e-18,Beta-loop-helix junction motif,True,assigned_too_few_test_positives +14664,85762,29.737146,0.89160156,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.87402344,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,C-terminal active-site gate,True,assigned_too_few_test_positives +14665,82029,34.749554,1.0,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9868164,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,18.0,18.0,188.0788643533123,6.824310871704072e-41,MFS TM helix-loop boundaries,True,assigned_too_few_test_positives +14666,64058,18.640823,0.64208984,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.64208984,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.6404687599515954,0.2901449458826508,0.006202924235711121,0.2857142857142857,46.77551020408163,17.0,18.0,107.66486084554917,7.098651611345337e-34,C-terminal oxidoreductase catalytic lobe,True,assigned_and_evaluated +14667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity N-termini,False,no_term_above_threshold +14668,36668,18.38389,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9863281,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,ANL A-motif loop,True,assigned_too_few_test_positives +14669,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNase T2 mature-domain detector,False,no_term_above_threshold +14670,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory-domain signature,False,no_term_above_threshold +14671,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-x-Pro connector loops,False,no_term_above_threshold +14672,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity terminal tails,False,no_term_above_threshold +14673,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic disordered NLS flanks,False,no_term_above_threshold +14674,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-to-C-terminal interaction tails,False,no_term_above_threshold +14675,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal disordered scaffolding hubs,False,no_term_above_threshold +14676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic amphipathic helical scaffolds,False,no_term_above_threshold +14677,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity regulatory IDRs,False,no_term_above_threshold +14678,45551,29.073795,0.9038086,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9038086,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,10.0,0.0,1.0,ABC NBD C-terminal beta-strand,True,assigned_too_few_test_positives +14679,64585,20.9241,0.96728516,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.9267578,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,19.0,0.0,1.0,N-terminal IDR interaction tail,True,assigned_too_few_test_positives +14680,59224,18.814722,0.953125,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.953125,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9961904761904762,0.4118360805860806,0.0031014621178555605,0.7142857142857143,132.787719126112,2.0,12.0,22.895929339477725,0.005747865812846772,Generic beta-strand signal,True,assigned_and_evaluated +14681,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-hydrophobic membrane helices; His/Zn-adjacent,False,no_term_above_threshold +14682,47128,24.257347,0.96875,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.96875,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,9.0,14.0,165.20597290640396,8.659811067875157e-19,Trp/Tyr-lined ligand grooves,True,assigned_too_few_test_positives +14683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered regulatory tails,False,no_term_above_threshold +14684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Targeting peptides and beta ectodomains,False,no_term_above_threshold +14685,85664,22.702616,0.9370117,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9370117,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,11.0,13.0,280.2696581196581,3.420524387353267e-26,Catalytic donor-binding loop-helix segments,True,assigned_too_few_test_positives +14686,52236,15.6339855,0.7973633,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7890625,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,4.0,18.0,49.62213899292551,2.199220186020915e-06,Broad helical TPR activation,True,assigned_too_few_test_positives +14687,37894,15.905073,0.7993164,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7993164,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,15.0,0.0,1.0,Active-site helix N-cap,True,assigned_too_few_test_positives +14688,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended effector-region activation,False,no_term_above_threshold +14689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane pre-TM linker,False,no_term_above_threshold +14690,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Upstream P-loop activation,False,no_term_above_threshold +14691,61392,19.293543,0.74316406,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.74316406,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.7066666666666667,0.05428858832280072,0.0031014621178555605,,17.504191977794463,15.0,15.0,167.4747191011236,1.5239103019764629e-33,Alpha-helical interaction scaffolds,True,assigned_and_evaluated +14692,88009,16.196938,0.61865234,Repeat,keyword,88009,Repeat,0.61865234,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6611236059804458,0.15501669210483449,0.07266282676118742,,2.1333699639061674,11.0,20.0,4.876066914498142,4.487515676070656e-06,Long disordered low-complexity repeats,True,assigned_and_evaluated +14693,37690,23.368263,0.75634766,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.73583984,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.6996190476190477,0.01960432459543234,0.0031014621178555605,,6.320994373127256,4.0,15.0,48.178585858585855,2.2993897237719884e-06,"Acidic disordered tails, ankyrin repeats",True,assigned_and_evaluated +14694,85649,23.466122,0.9711914,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9667969,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9459732980421159,0.7400948046711936,0.0101905183872397,0.782608695652174,72.62582496273409,19.0,19.0,110.61410018552876,7.972136883844738e-39,Aromatic cage beta-strand,True,assigned_and_evaluated +14695,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short core binding-site motifs,False,no_term_above_threshold +14696,38654,15.615782,0.72216797,B3 DNA binding domain,interpro,83267,DNA-binding pseudobarrel domain,0.70996094,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,17.0,0.0,1.0,Catalytic core helical scaffold,True,assigned_too_few_test_positives +14697,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended acidic/polar surface segments,False,no_term_above_threshold +14698,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VWFD/nidogen beta-sandwich domains,False,no_term_above_threshold +14699,59224,34.07112,0.98535156,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.98535156,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,19.0,19.0,137.37557603686636,1.4828928465544412e-40,α/β-hydrolase nucleophile elbow motif,True,assigned_and_evaluated +14700,36104,16.60244,0.8388672,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8388672,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,20.0,0.0,1.0,Coiled-coil hinge junctions,True,assigned_too_few_test_positives +14701,28679,22.159872,0.73339844,serine-type endopeptidase inhibitor activity,go_mf,87966,Protease inhibitor,0.6635742,116,go,GO:0004867,go_mf:go:GO:0004867,6.0,2257.0,0.5719309936324596,0.008881996750849209,0.002658396101019052,,3.3411111111111107,7.0,12.0,146.12990196078434,2.6507398229774555e-14,Extracellular disulfide-rich inhibitory loops,True,assigned_and_evaluated +14702,85649,21.186998,0.9555664,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.95458984,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9366898914016581,0.17486452580064055,0.0101905183872397,,17.159531944871553,2.0,16.0,13.826762523191094,0.015365107207123668,Binding pocket beta-strand activation,True,assigned_and_evaluated +14703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metabolic enzyme active sites,False,no_term_above_threshold +14704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interfacial aromatic-proline helix kinks,False,no_term_above_threshold +14705,50338,22.770262,0.95947266,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.95947266,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,19.0,0.0,1.0,Post-His DHp helix,True,assigned_too_few_test_positives +14706,46081,23.731977,0.953125,EF-hand domain pair,interpro,46081,EF-hand domain pair,0.953125,76,ip,IPR011992,interpro:ip:IPR011992,8.0,2257.0,0.9954424188528235,0.28911539849039847,0.003544528134692069,,81.56668179910366,0.0,11.0,0.0,1.0,Kinase C-lobe hydrophobic scaffold,True,assigned_and_evaluated +14707,37020,15.969743,0.9824219,"Glycosyl transferase, family 1",interpro,85682,NAD(P)-binding Rossmann-like Domain,0.70996094,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,0.0,17.0,0.0,1.0,SDR Tyr-X3-Lys catalytic loop,True,assigned_too_few_test_positives +14708,59224,33.637856,0.98535156,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.98535156,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,17.0,17.0,137.37557603686636,1.8959130288093467e-36,Hydrophobic loop after catalytic Ser,True,assigned_and_evaluated +14709,45324,17.533907,0.82128906,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.82128906,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.49400532859680285,0.002215330084182543,0.002215330084182543,,1.0,5.0,18.0,151.93934760448522,3.272141924785821e-10,Extracellular beta-rich enzymes and adhesins,True,assigned_and_evaluated +14710,47717,16.195904,0.99121094,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7529297,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,13.0,0.0,1.0,Phosphate-coupling Ser/Thr residues,True,assigned_too_few_test_positives +14711,69819,20.48313,0.8076172,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.7944336,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,18.0,18.0,419.86619718309856,6.513624004794376e-47,Nucleotide phosphate-binding clefts,True,assigned_too_few_test_positives +14712,88263,19.762184,0.7597656,Zinc-finger,keyword,88263,Zinc-finger,0.7597656,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.857872792674951,0.10289665062879412,0.014621178555604785,0.09090909090909091,7.037507286945101,1.0,18.0,1.4476738539238538,0.7842877320195357,SPS N-terminal regulatory motif,True,assigned_and_evaluated +14713,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Central amphipathic interface segment,False,no_term_above_threshold +14714,85649,22.86222,0.96240234,Vaccinia Virus protein VP39,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7675781,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9309485812152116,0.5047421324727626,0.0101905183872397,0.6956521739130435,49.53056491265326,0.0,12.0,0.0,1.0,Rossmann-like nucleotide-binding pocket,True,assigned_and_evaluated +14715,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aminotransferase PLP-binding motifs,False,no_term_above_threshold +14716,85649,32.753883,0.96777344,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9614258,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9082752714958546,0.7706091683649448,0.0101905183872397,0.782608695652174,75.62021273911652,16.0,16.0,110.61410018552876,7.117153535323136e-33,Conserved C-terminal MTase segment,True,assigned_and_evaluated +14717,85762,27.23995,0.9116211,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9057617,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,14.0,14.0,205.58965517241379,1.3323113268805393e-32,Core beta-strand substrate wall,True,assigned_too_few_test_positives +14718,43583,18.07668,0.9711914,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9711914,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,0.9998785720068,0.9750688705234161,0.004873726185201595,1.0,200.0664037064864,13.0,13.0,416.9300699300699,2.4303600400252172e-34,S1 serine protease domain,True,assigned_and_evaluated +14719,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ribokinase-like nucleotide-binding loop,False,no_term_above_threshold +14720,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Targeting and transmembrane helices,False,no_term_above_threshold +14721,36104,16.382479,0.91796875,Rho GTPase-activating protein domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6254883,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,14.0,0.0,1.0,Microtubule-binding domain cores,True,assigned_too_few_test_positives +14722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal hydrophobic patch motif,False,no_term_above_threshold +14723,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical segments,False,no_term_above_threshold +14724,47717,17.11362,1.0,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.734375,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,16.0,239.30447247706422,2.583390169633023e-32,Helicase P-loop ATP-binding core,True,assigned_too_few_test_positives +14725,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface-adjacent helical micro-motifs,False,no_term_above_threshold +14726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M13 neprilysin metallopeptidase domain,False,no_term_above_threshold +14727,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intradiol ring-cleavage dioxygenases,False,no_term_above_threshold +14728,87326,34.05359,0.70947266,Coiled coil,keyword,87326,Coiled coil,0.70947266,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7372558978398772,0.33943281275318327,0.03943287549844927,0.33707865168539325,8.607863577347581,18.0,18.0,12.607528018608585,3.905291109887263e-20,Long amphipathic coiled-coil scaffolds,True,assigned_and_evaluated +14729,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad catalytic domain activation,False,no_term_above_threshold +14730,66234,16.8508,0.76123047,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.76123047,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,4.0,16.0,59.147817460317455,1.0542977048123124e-06,Cys-His catalytic domains,True,assigned_too_few_test_positives +14731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Antiparallel β-hairpin motif,False,no_term_above_threshold +14732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,xDG/xNG/xPSG turn motif,False,no_term_above_threshold +14733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic and lumenal coupling regions,False,no_term_above_threshold +14734,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal periplasmic β-strand interface,False,no_term_above_threshold +14735,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chemotaxis receptor coiled-coil stalks,False,no_term_above_threshold +14736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pan-protein cyanobacterial signaling activation,False,no_term_above_threshold +14737,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MutS/MSH ATPase clamp helices,False,no_term_above_threshold +14738,49121,17.243668,0.9667969,"Signal transduction response regulator, C-terminal effector",interpro,87566,Homeobox,0.8125,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,10.0,0.0,1.0,HTH C-terminal basic tail,True,assigned_too_few_test_positives +14739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor transmembrane helix,False,no_term_above_threshold +14740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular enzyme active site signatures,False,no_term_above_threshold +14741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type II signal-anchor helix,False,no_term_above_threshold +14742,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic scaffold-biased activation,False,no_term_above_threshold +14743,88161,25.785763,0.62402344,Transmembrane helix,keyword,88161,Transmembrane helix,0.62402344,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.5611054634553226,0.2087867186258506,0.1847585290208241,,1.1300518559677335,9.0,20.0,2.442371415566682,0.00982778148050158,Transmembrane and disordered-region peaks,True,assigned_and_evaluated +14744,47529,19.239695,0.9116211,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9116211,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9324520303435966,0.049107783487678844,0.007089056269384138,,6.927266708230697,3.0,20.0,11.599416342412452,0.0036188049688884822,Extracellular beta-strand hydrophobics,True,assigned_and_evaluated +14745,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix and juxtamembrane flanks,False,no_term_above_threshold +14746,82029,22.793253,0.99560547,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7319336,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,4.0,17.0,44.253850436073485,3.3742587914065196e-06,Hydrophobic transmembrane helix cores,True,assigned_too_few_test_positives +14747,37341,19.391325,0.99609375,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.98535156,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,13.0,18.0,105.02344173441733,1.5699660829275456e-24,Periodic acidic interstrand loops,True,assigned_and_evaluated +14748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C5-biased DNA methyltransferase core,False,no_term_above_threshold +14749,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical membrane-interface hydrophobicity,False,no_term_above_threshold +14750,63951,18.58887,0.79052734,Immunoglobulin-like domain superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.79052734,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9302589956504547,0.2370105823625965,0.003987594151528578,0.3333333333333333,59.43698715470892,14.0,14.0,161.13783783783785,3.975102145623941e-31,Disordered immunoreceptor cytoplasmic tails,True,assigned_and_evaluated +14751,59224,19.726633,0.9511719,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7636719,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9697142857142858,0.07197148665466777,0.0031014621178555605,,23.20566362565502,0.0,17.0,0.0,1.0,Helical rims of cofactor pockets,True,assigned_and_evaluated +14752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge helix–turn–β module,False,no_term_above_threshold +14753,50338,21.47668,0.88134766,"GPCR, rhodopsin-like, 7TM",interpro,88152,Transducer,0.7495117,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,12.0,0.0,1.0,ABC transporter transmembrane domains,True,assigned_too_few_test_positives +14754,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane helical stalk,False,no_term_above_threshold +14755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature catalytic and extracellular regions,False,no_term_above_threshold +14756,63831,16.306007,0.86572266,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.86572266,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8428106026950984,0.009406587320692541,0.002658396101019052,,3.538444597133844,0.0,17.0,0.0,1.0,LacI regulatory domain helix starts,True,assigned_and_evaluated +14757,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide cyclase catalytic cores,False,no_term_above_threshold +14758,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulatory disordered tails,False,no_term_above_threshold +14759,87277,20.082535,0.83496094,Cell outer membrane,keyword,88058,Signal,0.80566406,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.7449523809523809,0.019262758985222533,0.0031014621178555605,,6.210863861378179,0.0,15.0,0.0,1.0,N-terminal signal peptide/anchor,True,assigned_and_evaluated +14760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal noncatalytic extensions,False,no_term_above_threshold +14761,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site β-sheet scaffolds,False,no_term_above_threshold +14762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted disulfide-rich extracellular regions,False,no_term_above_threshold +14763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane signal-anchor helices,False,no_term_above_threshold +14764,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic lipid-transfer scaffolds,False,no_term_above_threshold +14765,82764,17.068918,0.9267578,Kelch-type beta propeller,gene3d,82764,Kelch-type beta propeller,0.9267578,38,gene3d,2.120.10.80,gene3d:gene3d:2.120.10.80,,,,,,,,0.0,16.0,0.0,1.0,Beta-propeller blade-edge signature,True,assigned_too_few_test_positives +14766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIR catalytic/interaction patch,False,no_term_above_threshold +14767,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly-flanked hydrophobic loop,False,no_term_above_threshold +14768,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine metal-binding cores,False,no_term_above_threshold +14769,52236,23.300268,0.9814453,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.96484375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,19.0,164.5365661344372,3.7958279824341706e-29,Alpha-solenoid inter-helix turns,True,assigned_too_few_test_positives +14770,55053,22.663958,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,12.0,12.0,552.0462962962963,3.0471251534694055e-33,NRPS condensation/acyltransferase cores,True,assigned_too_few_test_positives +14771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GT-C periplasmic acceptor loop,False,no_term_above_threshold +14772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal catalytic core detector,False,no_term_above_threshold +14773,85664,16.236513,0.9003906,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.734375,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,15.0,0.0,1.0,Short ligand-binding beta-strand cores,True,assigned_too_few_test_positives +14774,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LMW-PTP domain-wide activation,False,no_term_above_threshold +14775,64317,16.758312,0.828125,"Knottin, scorpion toxin-like superfamily",interpro,64317,"Knottin, scorpion toxin-like superfamily",0.828125,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,13.0,0.0,1.0,Cadherin extracellular adhesion modules,True,assigned_too_few_test_positives +14776,46079,37.202404,0.9770508,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9770508,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9974804607157549,0.5817463513438745,0.0057598582188746125,1.0,101.00011653716345,14.0,20.0,65.21046874999999,2.4466175300843938e-23,Alpha-helical repeat scaffolds,True,assigned_and_evaluated +14777,87913,19.231989,0.8652344,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.8652344,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.7094134131583976,0.08288075867433875,0.006202924235711121,,13.361562309141611,0.0,10.0,0.0,1.0,ABC NBD D-loop/signature interface,True,assigned_and_evaluated +14778,63831,18.032337,0.9667969,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9667969,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9809343995261365,0.08706454689370767,0.002658396101019052,,32.7507803898497,0.0,17.0,0.0,1.0,FBPA N-terminal helix motif,True,assigned_and_evaluated +14779,87326,40.433655,0.76220703,Coiled coil,keyword,87326,Coiled coil,0.76220703,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.816620195696339,0.38416724896712107,0.03943287549844927,0.21348314606741572,9.742308774368453,15.0,18.0,10.50627334884049,4.501608829624033e-14,Long heptad coiled-coil rods,True,assigned_and_evaluated +14780,31094,15.807023,0.94189453,phosphopantetheine binding,go_mf,36668,AMP-dependent synthetase/ligase domain,0.86035156,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.944481530930129,0.5381014076751781,0.004430660168365086,0.7,121.4494877122877,0.0,15.0,0.0,1.0,ALDH internal conserved segment activation,True,assigned_and_evaluated +14781,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S2P/M50 GFG loop motif,False,no_term_above_threshold +14782,85672,15.620646,0.7319336,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73095703,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8263169743358847,0.060304126281026306,0.01595037660611431,,3.780733694896566,3.0,16.0,7.5026426174496645,0.011722483303356672,Plant cysteine synthase C-terminal motif,True,assigned_and_evaluated +14783,46932,22.684122,0.8129883,Zinc finger C2H2-type,interpro,46932,Zinc finger C2H2-type,0.8129883,133,ip,IPR013087,interpro:ip:IPR013087,10.0,2257.0,0.8970627503337785,0.727433751081292,0.004430660168365086,0.8,164.18179761904761,17.0,17.0,108.20508166969147,1.0262878880954455e-34,Zinc finger regulatory IDRs,True,assigned_and_evaluated +14784,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity charged tails,False,no_term_above_threshold +14785,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site proximal segment,False,no_term_above_threshold +14786,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical assembly scaffolds,False,no_term_above_threshold +14787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mixed-charge nuclear IDR PTM hotspots,False,no_term_above_threshold +14788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Repeat-based solenoid scaffolds,False,no_term_above_threshold +14789,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor pocket shaping loop,False,no_term_above_threshold +14790,63951,21.707617,0.85791016,Immunoglobulin-like domain superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.85791016,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9405891656781337,0.31190384466027765,0.003987594151528578,,78.21855304424963,0.0,14.0,0.0,1.0,Extracellular low-complexity linkers and stalks,True,assigned_and_evaluated +14791,46082,16.81176,0.9746094,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.9746094,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9996825396825397,0.9129251700680272,0.0031014621178555605,1.0,294.3531584062196,16.0,16.0,150.93924050632913,5.241814974793697e-35,PH-domain phosphoinositide binding,True,assigned_and_evaluated +14792,37894,19.29552,0.7841797,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.7841797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,15.0,473.18253968253964,1.6267926303022185e-25,N-terminal DNA/ubiquitin recruitment modules,True,assigned_too_few_test_positives +14793,63831,17.086967,0.9213867,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9213867,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9046349770472383,0.015157632141391344,0.002658396101019052,,5.70179595718671,0.0,19.0,0.0,1.0,Secretory phosphoserine hotspots,True,assigned_and_evaluated +14794,45321,17.349972,0.9111328,Quinoprotein alcohol dehydrogenase-like superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8442383,27,ip,IPR011047,interpro:ip:IPR011047,,,,,,,,18.0,19.0,482.7611336032389,3.1113490681660496e-47,Extracytoplasmic beta-propeller PCCD motif,True,assigned_too_few_test_positives +14795,83302,20.636705,0.9511719,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.9506836,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9811381850562617,0.13352658780003307,0.004873726185201595,,27.39722806042497,0.0,16.0,0.0,1.0,MutS2 Smr upstream hydrophobic motif,True,assigned_and_evaluated +14796,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase C-terminal regulatory region,False,no_term_above_threshold +14797,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtadomain coupling helix,False,no_term_above_threshold +14798,87326,20.597128,0.62158203,Coiled coil,keyword,87326,Coiled coil,0.62158203,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6113204320245449,0.11686346737903233,0.03943287549844927,0.07865168539325842,2.963605009825573,13.0,19.0,8.626203381153243,1.7506259806341123e-10,Charge-patterned coiled-coil/IDR scaffolds,True,assigned_and_evaluated +14799,37341,22.710096,0.8959961,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.8461914,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9800365387809332,0.8206607400818706,0.011962782454585734,0.9629629629629629,68.60115890239933,14.0,14.0,145.4170731707317,1.641824266420136e-30,N-terminal pre-WD40 regulatory region,True,assigned_and_evaluated +14800,36535,18.965162,0.90283203,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8828125,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9287271918113039,0.09810731762139832,0.004430660168365086,,22.1428215871496,0.0,8.0,0.0,1.0,ABC NBD pre-signature junction,True,assigned_and_evaluated +14801,87108,17.153166,0.64941406,ANK repeat,keyword,87108,ANK repeat,0.64941406,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.662860814551206,0.049250366222400935,0.003987594151528578,,12.350897395995435,0.0,18.0,0.0,1.0,Alpha-helical interaction scaffolds,True,assigned_and_evaluated +14802,85649,34.726753,0.7841797,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.78125,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8242575220894477,0.5809233584546989,0.0101905183872397,0.6521739130434783,57.00626174053284,15.0,15.0,110.61410018552876,7.1622047874657735e-31,SAM-dependent MTase helical lid,True,assigned_and_evaluated +14803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic-aromatic anion-binding motifs,False,no_term_above_threshold +14804,87149,19.80003,0.6772461,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6772461,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.5954784336345574,0.01666185116321406,0.012405848471422242,,1.3430642169776474,0.0,18.0,0.0,1.0,Regulatory helices and catalytic pockets,True,assigned_and_evaluated +14805,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-edge hydrophobic/proline segments,False,no_term_above_threshold +14806,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase switch/lid segment,False,no_term_above_threshold +14807,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-helix packing interfaces,False,no_term_above_threshold +14808,47529,26.296509,0.89453125,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.89453125,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9499804774654173,0.30273572078430405,0.007089056269384138,0.1875,42.70465761313589,3.0,16.0,14.499270428015565,0.0018658908624807312,Aspartate beta-strand motifs,True,assigned_and_evaluated +14809,81799,19.250576,0.85058594,1.10.8.60,gene3d,38873,AAA+ ATPase domain,0.7890625,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,5.0,8.0,361.7779126213592,1.7144721616391402e-12,AAA+ disordered tails and insertions,True,assigned_too_few_test_positives +14810,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLH domain detector,False,no_term_above_threshold +14811,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short structured interaction motifs,False,no_term_above_threshold +14812,50338,18.011793,0.8696289,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8696289,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,11.0,0.0,1.0,Pocket-lining transmembrane helices,True,assigned_too_few_test_positives +14813,82597,31.17799,0.94189453,Tetratricopeptide repeat domain,gene3d,46079,Tetratricopeptide-like helical domain superfamily,0.94140625,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.9408508158508159,0.2642620890113502,0.0057598582188746125,0.23076923076923078,45.879964222970564,18.0,18.0,97.41993464052287,6.877577713649918e-36,Alpha-solenoid interhelical linkers,True,assigned_and_evaluated +14814,49061,26.864275,0.9814453,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9814453,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9952893674293406,0.5259757562859334,0.012405848471422242,1.0,42.39740292633399,2.0,18.0,10.98599594619495,0.02379117681115596,β-propeller blade β-strand signature,True,assigned_and_evaluated +14815,49116,20.409267,0.8354492,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8354492,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.9895204262877442,0.38628312863606984,0.002215330084182543,0.4,174.36820426632192,4.0,18.0,19.34176804541768,8.551054511298527e-05,N-terminal disordered scaffolds,True,assigned_and_evaluated +14816,87697,26.29295,0.94970703,Knottin,keyword,29166,zinc ion binding,0.87353516,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9757751265866685,0.24552584906096506,0.017279574656623838,,14.209021572579438,0.0,17.0,0.0,1.0,Cys/His-rich zinc knuckles,True,assigned_and_evaluated +14817,36535,22.137665,0.9667969,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.859375,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.998931909212283,0.9203030303030303,0.004430660168365086,0.9,207.71239393939396,15.0,15.0,89.79066265060241,1.585928718533337e-29,Kinase alphaC-loop and P-loop,True,assigned_and_evaluated +14818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-centered beta-turn hinges,False,no_term_above_threshold +14819,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peripheral non-cofactor segments,False,no_term_above_threshold +14820,37894,17.017714,0.86621094,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.86621094,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,Amphipathic coiled-coil linker helices,True,assigned_too_few_test_positives +14821,87276,36.755344,0.66552734,Cell membrane,keyword,88161,Transmembrane helix,0.6513672,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7571220601144772,0.42479212165684793,0.11120957022596367,0.5617529880478087,3.819744297129505,7.0,20.0,2.8719171483622348,0.01245792541716605,Transmembrane helices and flanking loops,True,assigned_and_evaluated +14822,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded-domain interface residue detector,False,no_term_above_threshold +14823,36104,16.419945,0.99560547,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.9902344,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,15.0,16.0,547.9871323529412,1.5691556956573954e-40,Proline-rich regulatory IDRs,True,assigned_too_few_test_positives +14824,85649,24.58192,0.75439453,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7524414,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6789537192012767,0.24161912639104371,0.0101905183872397,0.30434782608695654,23.7101899245472,17.0,17.0,110.61410018552876,7.110790058883305e-35,Accessory substrate recognition modules,True,assigned_and_evaluated +14825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged S/T-rich IDRs,False,no_term_above_threshold +14826,45804,17.13544,0.92822266,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.7871094,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,20.0,0.0,1.0,Juxtamembrane terminal tails,True,assigned_too_few_test_positives +14827,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptide cleavage signature,False,no_term_above_threshold +14828,88160,16.2511,0.79345703,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6933594,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,14.0,18.0,225.10625674217906,2.719861911906338e-31,Outer-membrane β-barrel loop hairpins,True,assigned_too_few_test_positives +14829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intein HE-centric; PrimPol activation,False,no_term_above_threshold +14830,87852,18.773876,0.87158203,Nucleosome core,keyword,24789,nucleosome,0.8305664,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,1.0,16.0,39.22434210526316,0.04216613865385962,Lys-interleaved low-complexity segments,True,assigned_too_few_test_positives +14831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic cleft-flanking segments,False,no_term_above_threshold +14832,29034,18.022106,0.74072266,GTP binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.6791992,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.7144166294143942,0.361504794647256,0.008861320336730172,0.4,40.79581607594284,5.0,9.0,72.00603864734299,6.687706659912303e-09,N-terminal/interdomain amphipathic boundary segments,True,assigned_and_evaluated +14833,47717,15.79386,0.87939453,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.62060547,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,16.0,170.93176605504587,7.253911057990296e-21,XPD-family helicase FeS module,True,assigned_too_few_test_positives +14834,84152,30.399012,0.9560547,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9560547,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,18.0,18.0,562.4622641509434,5.407112538669923e-49,Amidohydrolase active-site motifs,True,assigned_too_few_test_positives +14835,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended noncatalytic regional activation,False,no_term_above_threshold +14836,87545,15.802845,0.7368164,Hemolysis,keyword,87149,Amphibian defense peptide,0.6713867,102,keywords,Hemolysis,keyword:keywords:Hemolysis,8.0,2257.0,0.9781847487772343,0.07863768377425684,0.003544528134692069,,22.18565653481221,0.0,19.0,0.0,1.0,Juxtamembrane aromatic basic motifs,True,assigned_and_evaluated +14837,63774,25.17545,0.9790039,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.9790039,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,1.0,18.0,10.160361281526924,0.15228146957346375,Beta-strand hydrophobic-Arg motif,True,assigned_too_few_test_positives +14838,37894,16.075274,0.6689453,Short-chain dehydrogenase/reductase SDR,interpro,38873,AAA+ ATPase domain,0.6303711,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,7.0,0.0,1.0,ABC NBD ATPase cassette,True,assigned_too_few_test_positives +14839,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity regulatory IDRs,False,no_term_above_threshold +14840,50338,17.495396,0.8930664,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6010742,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,Transporter transmembrane helices,True,assigned_too_few_test_positives +14841,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic TM helix-loop junctions,False,no_term_above_threshold +14842,38873,20.914572,0.9794922,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9404297,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9966252220248667,0.6764492753623188,0.002215330084182543,0.6,305.34920289855074,11.0,11.0,171.32471264367817,6.880872708632078e-25,Post-P-loop alpha1 hydrophobe,True,assigned_and_evaluated +14843,81858,17.159616,0.9448242,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.9448242,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,9.0,18.0,130.74780701754386,1.730093529580107e-17,GPCR TM1 signal-anchor helix,True,assigned_too_few_test_positives +14844,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic and interaction hotspots,False,no_term_above_threshold +14845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged accessory helix-loop-beta modules,False,no_term_above_threshold +14846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MHC I ectodomain platform,False,no_term_above_threshold +14847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic TM/active-site core segment,False,no_term_above_threshold +14848,30856,17.659632,0.8876953,transmembrane transporter activity,go_mf,88161,Transmembrane helix,0.77783203,139,go,GO:0022857,go_mf:go:GO:0022857,5.0,2257.0,0.8733126110124334,0.010334392624328202,0.002215330084182543,,4.66494483062175,6.0,16.0,50.24241573033708,2.57722412022504e-09,Generic transmembrane helix signal,True,assigned_and_evaluated +14849,50338,15.77757,0.9091797,"GPCR, rhodopsin-like, 7TM",interpro,87276,Cell membrane,0.6274414,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,17.0,0.0,1.0,RND efflux TM helices,True,assigned_too_few_test_positives +14850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site cofactor-binding loops,False,no_term_above_threshold +14851,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aminoacylation and tRNA-binding surfaces,False,no_term_above_threshold +14852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic amphipathic helix motif,False,no_term_above_threshold +14853,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide/phosphate-binding catalytic cores,False,no_term_above_threshold +14854,37894,19.010082,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.86572266,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,14.0,14.0,709.7738095238095,3.3915309155506114e-40,SDR Rossmann cofactor-binding scaffold,True,assigned_too_few_test_positives +14855,83419,16.19411,0.9013672,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.88623047,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,3.0,15.0,72.70853658536586,1.698423473581679e-05,Extracellular carbohydrate-recognition domains,True,assigned_too_few_test_positives +14856,58239,43.189583,0.80615234,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.80615234,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7959460983310781,0.5119072977312087,0.017722640673460344,0.575,28.88436927448345,10.0,11.0,32.59224840102771,6.941692638995478e-15,P-loop NTPase motor core,True,assigned_and_evaluated +14857,87384,16.589695,0.6381836,DNA-binding,keyword,87384,DNA-binding,0.6381836,1310,keywords,DNA-binding,keyword:keywords:DNA-binding,99.0,2257.0,0.7059566939085011,0.08304461735444749,0.043863535666814356,,1.8932495087776564,0.0,16.0,0.0,1.0,Trm9/ALKBH8 RYYHV motif,True,assigned_and_evaluated +14858,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble globular domain cores,False,no_term_above_threshold +14859,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface headgroup-processing enzymes,False,no_term_above_threshold +14860,39958,16.038603,0.74316406,Basic-leucine zipper domain,interpro,39958,Basic-leucine zipper domain,0.74316406,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9976677032430031,0.3702020202020202,0.002658396101019052,1.0,139.25765993265992,0.0,19.0,0.0,1.0,Acidic His-rich metallohydrolase patch,True,assigned_and_evaluated +14861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC TMD–NBD coupling loop,False,no_term_above_threshold +14862,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disordered regulatory regions,False,no_term_above_threshold +14863,64058,21.977903,0.9370117,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9355469,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9741417744092733,0.27844634120036826,0.006202924235711121,0.21428571428571427,44.88952800637365,5.0,19.0,29.99949683002918,1.0361672155888244e-06,Beta-strand N-cap motif,True,assigned_and_evaluated +14864,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal disordered regulatory linkers,False,no_term_above_threshold +14865,45804,26.96978,0.9785156,Major facilitator superfamily,interpro,64026,MFS transporter superfamily,0.94628906,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,11.0,19.0,159.80287524366472,2.2228802797470726e-22,Central glycine-zipper TM helix,True,assigned_too_few_test_positives +14866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intrinsic disorder and low-complexity regions,False,no_term_above_threshold +14867,64058,16.610226,0.82910156,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.82910156,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9338417935163366,0.047252665700028625,0.006202924235711121,,7.617804748926043,0.0,17.0,0.0,1.0,β→loop/α junction motifs,True,assigned_and_evaluated +14868,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Electropositive surface interaction patches,False,no_term_above_threshold +14869,55053,22.828037,0.96777344,Chloramphenicol acetyltransferase-like domain superfamily,interpro,43624,Homedomain-like superfamily,0.67871094,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,19.0,0.0,1.0,Short polybasic patches,True,assigned_too_few_test_positives +14870,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-hairpin/wing edge motif,False,no_term_above_threshold +14871,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal functional linear motifs,False,no_term_above_threshold +14872,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Propeptides and pocket-lining loops,False,no_term_above_threshold +14873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-motor linker activation,False,no_term_above_threshold +14874,50338,17.0874,0.97802734,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.96191406,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,16.0,19.0,330.3102493074792,9.870974636224192e-39,TM7-H8 GPCR interface microdomain,True,assigned_too_few_test_positives +14875,52236,22.552973,0.9897461,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98876953,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,18.0,173.67748647523928,1.0369554419320324e-29,TPR helix-B hydrophobic motif,True,assigned_too_few_test_positives +14876,52236,23.270092,0.99853516,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9946289,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR helical repeat signature,True,assigned_too_few_test_positives +14877,59224,36.71982,0.9970703,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9970703,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,14.0,14.0,137.37557603686636,3.637100936097115e-30,Active-site-adjacent ABH helix,True,assigned_and_evaluated +14878,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Strand-loop-helix catalytic capping motif,False,no_term_above_threshold +14879,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short TM boundary helices,False,no_term_above_threshold +14880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved R3H histidine,False,no_term_above_threshold +14881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LAGLIDADG inteins and HINT domains,False,no_term_above_threshold +14882,85656,20.133682,0.95166016,alpha/beta hydrolase,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.80615234,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.968031746031746,0.0929328374706526,0.0031014621178555605,,29.964202024466132,1.0,16.0,8.830124407582938,0.17346236752523847,Hydrophobic β-sheet edge signal,True,assigned_and_evaluated +14883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic prenyltransferase mid-region motif,False,no_term_above_threshold +14884,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short noncatalytic aromatic-polar motifs,False,no_term_above_threshold +14885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged IDRs and hinge residues,False,no_term_above_threshold +14886,87274,17.269398,0.6479492,Cell inner membrane,keyword,88161,Transmembrane helix,0.64404297,371,keywords,Cell inner membrane,keyword:keywords:Cell inner membrane,81.0,2257.0,0.7855846042120551,0.1582415948988971,0.0358883473637572,0.012345679012345678,4.409275057861861,10.0,17.0,22.93732928096026,4.304180067521873e-12,Transmembrane boundary interfacial loops,True,assigned_and_evaluated +14887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Start of mature domain,False,no_term_above_threshold +14888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad peptide deformylase activation,False,no_term_above_threshold +14889,-1,,,,,-1,,,0,,,,,,,,,,,,,,,UvrA ABC1 Pro-Trp patch,False,no_term_above_threshold +14890,37341,23.72678,0.9975586,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99316406,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.999609699385484,0.9653796938446546,0.011962782454585734,1.0,80.69859144471798,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 blade aromatic site,True,assigned_and_evaluated +14891,88058,26.285297,0.66259766,Signal,keyword,88058,Signal,0.66259766,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6688141706863335,0.12294353445104847,0.09127159946832078,,1.3470075594952253,3.0,20.0,1.0807432024169183,0.8334769282943363,Disordered termini and cleavage detector,True,assigned_and_evaluated +14892,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding basic IDRs,False,no_term_above_threshold +14893,52941,17.688448,0.9892578,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.69873047,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,12.0,16.0,195.26528384279476,4.369161980775387e-26,Hydrophobic transmembrane transporter helices,True,assigned_too_few_test_positives +14894,85672,15.742514,0.6977539,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.6977539,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.698621741958077,0.04151293247322098,0.01595037660611431,,2.6026302386683264,0.0,13.0,0.0,1.0,DAD SGGPM motif,True,assigned_and_evaluated +14895,87697,17.87082,0.9091797,Knottin,keyword,87413,Disulfide bond,0.68652344,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.765693278768121,0.03382544468907128,0.017279574656623838,,1.9575391964931765,0.0,19.0,0.0,1.0,Unknown generic feature,True,assigned_and_evaluated +14896,37630,20.993977,0.9194336,"von Willebrand factor, type A",interpro,64214,von Willebrand factor A-like domain superfamily,0.90234375,33,ip,IPR002035,interpro:ip:IPR002035,,,,,,,,12.0,18.0,446.59925093632955,3.965176062894125e-30,Domain C-terminal interaction tails,True,assigned_too_few_test_positives +14897,38890,21.787376,0.91845703,HNH nuclease,interpro,38890,HNH nuclease,0.91845703,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,4.0,17.0,304.9667519181586,1.5102901105306054e-09,Nuclease and NADase domains,True,assigned_too_few_test_positives +14898,85656,17.373272,0.88720703,alpha/beta hydrolase,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.7680664,117,gene3d,3.40.50.1820,gene3d:gene3d:3.40.50.1820,7.0,2257.0,0.9605079365079365,0.04122244689389041,0.0031014621178555605,,13.291294662787235,0.0,16.0,0.0,1.0,Active-site-adjacent hinge loops,True,assigned_and_evaluated +14899,45551,16.486647,0.9716797,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9716797,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,19.0,0.0,1.0,Aromatic nucleotide-handling loop,True,assigned_too_few_test_positives +14900,58239,15.969426,0.7163086,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7163086,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7994756427604872,0.048177599858383865,0.017722640673460344,,2.71842107200931,0.0,13.0,0.0,1.0,Helix boundary anchor residues,True,assigned_and_evaluated +14901,88160,17.72964,0.8144531,Transmembrane beta strand,keyword,25167,cell outer membrane,0.67285156,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,18.0,18.0,289.42233009708735,4.0738218914291243e-44,Transmembrane beta-barrel detector,True,assigned_too_few_test_positives +14902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helix and Arg motif,False,no_term_above_threshold +14903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic terminal tail-helix motifs,False,no_term_above_threshold +14904,82716,16.858591,0.953125,Laminin,gene3d,88058,Signal,0.6064453,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,6.0,15.0,115.76893203883495,1.6641897604263603e-11,Cysteine-rich modular ectodomains,True,assigned_too_few_test_positives +14905,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short gly/pro-rich disordered stretches,False,no_term_above_threshold +14906,87108,16.393536,0.8701172,ANK repeat,keyword,87108,ANK repeat,0.8701172,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8976126927639383,0.021169088305671387,0.003987594151528578,,5.308736922877814,0.0,14.0,0.0,1.0,Domain-core aliphatic motifs,True,assigned_and_evaluated +14907,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transporter re-entrant hairpins,False,no_term_above_threshold +14908,45290,23.022432,0.7807617,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.7807617,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.7262100644453586,0.3500310031650437,0.0057598582188746125,0.3076923076923077,60.770767241807974,9.0,16.0,41.30149322660099,3.62491507575791e-13,Kinase pre-catalytic loop helix,True,assigned_and_evaluated +14909,30398,18.717922,0.6586914,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.6586914,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6320731806039018,0.19834972293988687,0.004873726185201595,0.18181818181818182,40.697756788665885,13.0,13.0,72.00603864734299,1.9317143050495217e-24,ABC NBD dimer-interface motif,True,assigned_and_evaluated +14910,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting peptides,False,no_term_above_threshold +14911,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Disordered glycine-rich linkers, catalytic serines",False,no_term_above_threshold +14912,43583,18.406584,0.9819336,"Peptidase S1, PA clan",interpro,8200,proteolysis,0.61621094,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,15.0,16.0,390.87194055944053,2.606245505866116e-38,Peptidase S1 C-terminal segment,True,assigned_and_evaluated +14913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface and active-site helix-loops,False,no_term_above_threshold +14914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FHA/winged-helix hydrophobic patches,False,no_term_above_threshold +14915,52236,19.251043,0.9946289,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98583984,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,18.0,186.08302122347067,1.3855153806489415e-32,TPR helix boundary sensor,True,assigned_too_few_test_positives +14916,52236,28.075628,0.8666992,Tetratricopeptide repeat,interpro,52236,Tetratricopeptide repeat,0.8666992,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,15.0,208.41298377028713,5.90677576167075e-32,OGT/SPINDLY TPR–GT linker activation,True,assigned_too_few_test_positives +14917,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site supporting helix/loop,False,no_term_above_threshold +14918,64146,22.437798,0.8564453,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8564453,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8272666368914695,0.057006240382517656,0.007975188303057155,,7.147949141296798,2.0,18.0,7.426631788739411,0.04866133185221465,Solvent exposed amphipathic alpha-helices,True,assigned_and_evaluated +14919,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic N-terminal disordered tails,False,no_term_above_threshold +14920,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC ATPase helical arms,False,no_term_above_threshold +14921,49061,28.776186,0.9765625,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9765625,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9964910594116515,0.6057351264526374,0.012405848471422242,1.0,48.826577871557234,6.0,15.0,39.54958540630182,9.808549948588524e-09,Beta-propeller fold detector,True,assigned_and_evaluated +14922,45714,26.66865,0.99365234,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.99365234,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,9.0,0.0,1.0,Coiled-coil heptad core detector,True,assigned_too_few_test_positives +14923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ECF anti-sigma sensory helix,False,no_term_above_threshold +14924,63960,31.393093,0.8461914,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.8461914,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,18.0,18.0,193.57467532467533,4.1657852190163465e-41,Amphipathic gating lid helix,True,assigned_too_few_test_positives +14925,88178,15.697785,0.63671875,Ubiquinone,keyword,88178,Ubiquinone,0.63671875,43,keywords,Ubiquinone,keyword:keywords:Ubiquinone,,,,,,,,0.0,14.0,0.0,1.0,Membrane-interfacial loops in lipid enzymes,True,assigned_too_few_test_positives +14926,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RecA/RAD51 C-terminal accessory regions,False,no_term_above_threshold +14927,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural and domain boundary residues,False,no_term_above_threshold +14928,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved functional surface micro-motifs,False,no_term_above_threshold +14929,63831,15.769605,0.87158203,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.87158203,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8344069302532208,0.008748773417278657,0.002658396101019052,,3.2909969337996547,0.0,9.0,0.0,1.0,Amphipathic oligomerization helices,True,assigned_and_evaluated +14930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane helix-loop hairpins,False,no_term_above_threshold +14931,36449,17.235247,1.0,EamA domain,interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8413086,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,14.0,17.0,876.7794117647059,4.130431045501904e-40,Multi-pass transporter TM hotspots,True,assigned_too_few_test_positives +14932,49061,31.94533,0.9404297,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9404297,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.7005784144074858,0.1086877538623778,0.012405848471422242,,8.761009302406668,17.0,19.0,88.46617788251724,6.86044084266807e-32,Tryptophan-biased propeller and lectin beta-strands,True,assigned_and_evaluated +14933,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal carbohydrate-binding accessory domain,False,no_term_above_threshold +14934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-rich disordered regulatory tails,False,no_term_above_threshold +14935,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-rich RS/RG IDRs,False,no_term_above_threshold +14936,64148,30.838888,0.97753906,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.94433594,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9934034147029773,0.544306303815495,0.008418254319893664,0.2631578947368421,64.65785935324065,13.0,20.0,57.84126865671642,7.796169309495633e-21,Recognition helix patches,True,assigned_and_evaluated +14937,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate binding surface activation,False,no_term_above_threshold +14938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small/polar beta-strand repeats,False,no_term_above_threshold +14939,59211,19.986471,0.9160156,Nucleotide-diphospho-sugar transferases,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9160156,54,ip,IPR029044,interpro:ip:IPR029044,25.0,2257.0,0.8639336917562723,0.31476883470876654,0.011076650420912717,0.48,28.417330397507442,12.0,16.0,183.2612704918033,9.385710935598026e-26,Glycosyltransferase donor-binding helix,True,assigned_and_evaluated +14940,24917,17.582582,0.6376953,nucleus,go_cc,24917,nucleus,0.6376953,1728,go,GO:0005634,go_cc:go:GO:0005634,132.0,2257.0,0.8765614973262033,0.3284350234585966,0.05848471422241914,0.10606060606060606,5.61574127231858,13.0,17.0,4.374223295765586,3.255169959779929e-07,Conserved eukaryotic regulatory motif,True,assigned_and_evaluated +14941,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M24 aminopeptidase N-terminal subdomain,False,no_term_above_threshold +14942,61392,17.191208,0.9296875,Leucine-rich repeat domain superfamily,interpro,59224,Alpha/Beta hydrolase fold,0.90771484,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.9083492063492064,0.017859175414880947,0.0031014621178555605,,5.758308415912328,0.0,14.0,0.0,1.0,Active-site β-strand hydrophobic buttress,True,assigned_and_evaluated +14943,82029,22.88282,0.9975586,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.71484375,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,MFS transmembrane hydrophobic residues,True,assigned_too_few_test_positives +14944,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular spike/adhesin autochaperone/autoprotease,False,no_term_above_threshold +14945,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal peptides and signal-anchor helices,False,no_term_above_threshold +14946,64146,24.533348,0.7314453,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.7314453,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.6864671728450201,0.03162610085555155,0.007975188303057155,,3.9655616461655474,4.0,20.0,13.367937219730942,0.00035973048740076325,Positively charged connector loops,True,assigned_and_evaluated +14947,47128,20.397406,0.85839844,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.85839844,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,17.0,18.0,242.71000957854406,8.70422654690493e-40,Extracellular glycan-binding domains,True,assigned_too_few_test_positives +14948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic single-pass membrane helices,False,no_term_above_threshold +14949,50806,15.725979,0.7104492,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.7104492,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,13.0,0.0,1.0,Acidic interdomain linker loops,True,assigned_too_few_test_positives +14950,64148,36.54118,0.82958984,Winged helix DNA-binding domain superfamily,interpro,64148,Winged helix DNA-binding domain superfamily,0.82958984,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.8874700155213772,0.41710090534116456,0.008418254319893664,0.2631578947368421,49.547197018684656,15.0,15.0,88.9865671641791,1.8111397886309825e-29,N-terminal HTH DNA-binding core,True,assigned_and_evaluated +14951,38873,17.91666,0.9169922,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9135742,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8892539964476022,0.15514482040280142,0.002215330084182543,,70.03237192982456,2.0,20.0,17.13247126436782,0.010335862878412818,P-loop NTPase hydrophobic β-strands,True,assigned_and_evaluated +14952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helicase post-Walker-A and ATP-lid activation,False,no_term_above_threshold +14953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding basic motif,False,no_term_above_threshold +14954,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Decarboxylating dehydrogenase metal-binding loop,False,no_term_above_threshold +14955,85649,26.597322,0.73876953,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.73876953,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8818652446382002,0.38065514263823286,0.0101905183872397,0.21739130434782608,37.35385464932572,14.0,14.0,110.61410018552876,7.27210921345717e-29,C-terminal Rossmann-like MTase catalytic subregion,True,assigned_and_evaluated +14956,46082,23.157854,0.98291016,PH-like domain superfamily,interpro,46082,PH-like domain superfamily,0.98291016,70,ip,IPR011993,interpro:ip:IPR011993,7.0,2257.0,0.9984761904761905,0.5042517006802721,0.0031014621178555605,1.0,162.58515549076773,10.0,16.0,94.3370253164557,2.799281029738777e-18,Cytosolic hydrophobic-polar patch,True,assigned_and_evaluated +14957,55053,16.031614,0.93310547,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.93310547,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,17.0,0.0,1.0,Ligand-sensing beta-strand signature,True,assigned_too_few_test_positives +14958,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site motif-adjacent capping residues,False,no_term_above_threshold +14959,81858,17.105259,0.8618164,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.8618164,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,13.0,0.0,1.0,Transmembrane loop-helix junctions,True,assigned_too_few_test_positives +14960,37894,24.704813,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.97998047,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,8.0,8.0,709.7738095238095,3.1343957826349425e-23,SDR YXXXK catalytic loop,True,assigned_too_few_test_positives +14961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S1–S3 VSD scaffold,False,no_term_above_threshold +14962,83419,18.9492,0.91064453,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.87060547,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,17.0,18.0,343.3458672086721,2.6594257921519396e-42,Extracellular and luminal recognition interfaces,True,assigned_too_few_test_positives +14963,88009,27.360157,0.6791992,Repeat,keyword,88009,Repeat,0.6791992,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7755104121753114,0.2221109754089946,0.07266282676118742,0.012195121951219513,3.0567345823054928,5.0,16.0,2.770492565055762,0.04572774815096063,Helical histidine ligation and coiled-coils,True,assigned_and_evaluated +14964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic β-strand/helix modules,False,no_term_above_threshold +14965,63831,16.971615,0.88623047,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.88623047,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8043832370798163,0.007384393697614341,0.002658396101019052,,2.777762762585928,0.0,19.0,0.0,1.0,Internal hydrophobic helical patches,True,assigned_and_evaluated +14966,36668,21.229822,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9873047,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,ANL adenylation domain signature,True,assigned_too_few_test_positives +14967,64475,18.069616,0.90625,ACP-like superfamily,interpro,87913,Phosphopantetheine,0.88183594,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9186891539832717,0.29153279655895253,0.0057598582188746125,,50.61457860258122,0.0,6.0,0.0,1.0,LSGGQ C-loop hotspot,True,assigned_and_evaluated +14968,85762,22.142101,0.7167969,FAD/NAD(P)-binding domain,gene3d,85762,FAD/NAD(P)-binding domain,0.7167969,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,16.0,16.0,205.58965517241379,4.0182436921199225e-37,C-terminal core-adjacent regulatory helices,True,assigned_too_few_test_positives +14969,38317,22.462296,0.7944336,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7944336,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7798730158730158,0.08340939855176265,0.0031014621178555605,,26.893573218761183,0.0,14.0,0.0,1.0,Glycan-binding clefts and loops,True,assigned_and_evaluated +14970,59224,18.125364,0.7128906,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.7128906,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.7726666666666666,0.06677867719727537,0.0031014621178555605,,21.531353490607216,2.0,18.0,15.263952892985149,0.012811192401536386,C-terminal His/aromatic cap-helix,True,assigned_and_evaluated +14971,37071,17.800713,0.7026367,Homeodomain,interpro,64148,Winged helix DNA-binding domain superfamily,0.62890625,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,0.0,20.0,0.0,1.0,Aromatic hydrophobic helix/strand patches,True,assigned_too_few_test_positives +14972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic proline basic motif,False,no_term_above_threshold +14973,36977,19.268541,0.9609375,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.90283203,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,16.0,0.0,1.0,Ligand-binding beta-alpha hinge N-caps,True,assigned_too_few_test_positives +14974,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical targeting segments,False,no_term_above_threshold +14975,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic-core loops,False,no_term_above_threshold +14976,37690,30.93799,0.99316406,Ankyrin repeat,interpro,88009,Repeat,0.67529297,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9991111111111111,0.7337257980115122,0.0031014621178555605,1.0,236.5741608731404,18.0,18.0,180.66969696969696,1.390790500677779e-40,Ankyrin repeat boundary signal,True,assigned_and_evaluated +14977,36876,16.166567,0.91845703,Cytochrome P450,interpro,87079,heme,0.828125,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,0.9427639383155397,0.5883958539696245,0.003987594151528578,0.8888888888888888,147.55660471216027,0.0,15.0,0.0,1.0,MOSC hydrophobic motif activation,True,assigned_and_evaluated +14978,81858,15.884351,0.81689453,Rhodopsin 7-helix transmembrane proteins,gene3d,81858,Rhodopsin 7-helix transmembrane proteins,0.81689453,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,12.0,12.0,261.4956140350877,2.6616462540944853e-29,GPCR ICL3 disordered regulatory loops,True,assigned_too_few_test_positives +14979,37020,16.721584,0.9970703,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.98095703,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,17.0,768.6833199033038,1.7917833648140597e-45,Aromatic nucleotide-sugar binding loop,True,assigned_too_few_test_positives +14980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-tryptophan motif detector,False,no_term_above_threshold +14981,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-rich core scaffold detector,False,no_term_above_threshold +14982,28962,15.599983,0.6074219,oxygen carrier activity,go_mf,28962,oxygen carrier activity,0.6074219,51,go,GO:0005344,go_mf:go:GO:0005344,,,,,,,,0.0,15.0,0.0,1.0,Multicopper oxidase loop motif,True,assigned_too_few_test_positives +14983,36104,19.704077,0.9785156,Rho GTPase-activating protein domain,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9707031,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,19.0,0.0,1.0,Extracellular edge beta-strand motif,True,assigned_too_few_test_positives +14984,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic α-helical interaction surfaces,False,no_term_above_threshold +14985,36876,17.712542,0.9980469,Cytochrome P450,interpro,30838,heme binding,0.7373047,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0,0.003987594151528578,1.0,250.7777777777778,18.0,18.0,389.6797385620915,2.4234264751426887e-46,Cytochrome P450 catalytic core,True,assigned_and_evaluated +14986,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended assembly interface regions,False,no_term_above_threshold +14987,59224,20.063562,0.92578125,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.78027344,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9757460317460318,0.06475744235053497,0.0031014621178555605,,20.879649626451062,0.0,16.0,0.0,1.0,N-terminal pre-REC/Rossmann linker,True,assigned_and_evaluated +14988,84152,27.852436,1.0,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,1.0,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,12.0,12.0,562.4622641509434,2.423759813764581e-33,Amidohydrolase catalytic TIM barrel,True,assigned_too_few_test_positives +14989,-1,,,,,-1,,,0,,,,,,,,,,,,,,,t-SNARE N-terminal linker,False,no_term_above_threshold +14990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ordered noncatalytic alpha helices,False,no_term_above_threshold +14991,37097,17.779354,0.9560547,Cro/C1-type helix-turn-helix domain,interpro,37097,Cro/C1-type helix-turn-helix domain,0.9560547,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,0.0,6.0,0.0,1.0,ABC NBD switch helix,True,assigned_too_few_test_positives +14992,36951,20.452213,0.95751953,SET domain,interpro,36951,SET domain,0.95751953,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,18.0,0.0,1.0,Beta-rich ligand-binding domains,True,assigned_too_few_test_positives +14993,88009,22.402401,0.6425781,Repeat,keyword,88009,Repeat,0.6425781,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7888038525631316,0.3447449550711808,0.07266282676118742,0.29878048780487804,4.7444473389978965,10.0,13.0,6.819674006291107,1.3541544860976807e-07,Long disordered low-complexity regions,True,assigned_and_evaluated +14994,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature mitochondrial region activation,False,no_term_above_threshold +14995,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FYVE Zn-Cys and disordered low-complexity,False,no_term_above_threshold +14996,84753,16.273712,0.9116211,3.30.420.40,gene3d,84753,3.30.420.40,0.9116211,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,7.0,13.0,222.94177350427347,1.6557247354627767e-15,ASKHA phosphate-binding motif,True,assigned_too_few_test_positives +14997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical regulatory bundle,False,no_term_above_threshold +14998,-1,,,,,-1,,,0,,,,,,,,,,,,,,,BED HATC dimerization motif,False,no_term_above_threshold +14999,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PBP/β-lactamase catalytic loops,False,no_term_above_threshold +15000,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged oligomerization interfaces,False,no_term_above_threshold +15001,64317,15.625123,0.79833984,"Knottin, scorpion toxin-like superfamily",interpro,64317,"Knottin, scorpion toxin-like superfamily",0.79833984,48,ip,IPR036574,interpro:ip:IPR036574,,,,,,,,0.0,15.0,0.0,1.0,Disordered MoRF-rich tails and linkers,True,assigned_too_few_test_positives +15002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich catalytic cofactor loops,False,no_term_above_threshold +15003,63951,23.060143,0.97021484,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.93652344,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9959470146302887,0.5265767973856209,0.003987594151528578,0.5555555555555556,132.05375907770517,12.0,18.0,107.42522522522522,1.3617500904937426e-22,Extracellular loop Gly/Pro motifs,True,assigned_and_evaluated +15004,31094,16.980574,0.95996094,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.828125,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.8987538940809968,0.5635609572084982,0.004430660168365086,0.8,127.19570804195806,0.0,11.0,0.0,1.0,UvrC central region activation,True,assigned_and_evaluated +15005,84152,18.94425,0.9824219,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9824219,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,18.0,0.0,1.0,DHQase TIM-barrel catalytic core,True,assigned_too_few_test_positives +15006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic proline-rich IDRs,False,no_term_above_threshold +15007,85364,22.093456,0.75097656,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.75097656,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,12.0,301.1161616161616,4.8533732239191074e-30,HMBS/HisG catalytic cysteine motif,True,assigned_too_few_test_positives +15008,43583,17.275043,0.9794922,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.9794922,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,14.0,14.0,416.9300699300699,6.605101239071875e-37,Trypsin-like serine protease domains,True,assigned_and_evaluated +15009,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class I SAM-binding helix,False,no_term_above_threshold +15010,50869,20.799662,0.97998047,"DNA binding HTH domain, AraC-type",interpro,50869,"DNA binding HTH domain, AraC-type",0.97998047,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,13.0,0.0,1.0,Nucleotide/NA recognition interfaces,True,assigned_too_few_test_positives +15011,37097,31.829708,0.9682617,Cro/C1-type helix-turn-helix domain,interpro,45272,"Lambda repressor-like, DNA-binding domain superfamily",0.9638672,49,ip,IPR001387,interpro:ip:IPR001387,,,,,,,,6.0,15.0,224.98490566037736,3.029948982734639e-13,Acidic D/E-rich regions,True,assigned_too_few_test_positives +15012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic coiled-coil stalks,False,no_term_above_threshold +15013,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical and disordered small hydrophobics,False,no_term_above_threshold +15014,88153,16.47722,0.6455078,Transferase,keyword,87601,Hydrolase,0.62060547,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.7341916186493305,0.16134797929270878,0.052724856003544526,0.06722689075630252,3.0601881450726363,5.0,15.0,3.7818585474151596,0.012832486587239546,Thymidylate synthase helical patch,True,assigned_and_evaluated +15015,45324,22.36066,0.9814453,Pectin lyase fold/virulence factor,interpro,64507,Ankyrin repeat-containing domain superfamily,0.76416016,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9990230905861457,0.5449999999999999,0.002215330084182543,1.0,246.01299999999998,15.0,15.0,546.9816513761467,3.1549135532889026e-41,Pectate lyase-like beta-helix,True,assigned_and_evaluated +15016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotidyltransferase fold core,False,no_term_above_threshold +15017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic helical interaction scaffolds,False,no_term_above_threshold +15018,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic cytochrome c domains,False,no_term_above_threshold +15019,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pepsin-like A1 C-terminal lobe,False,no_term_above_threshold +15020,84152,20.06315,0.8623047,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8623047,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,18.0,0.0,1.0,Metal-dependent enolase TIM barrel,True,assigned_too_few_test_positives +15021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha helices,False,no_term_above_threshold +15022,88161,35.66976,0.68603516,Transmembrane helix,keyword,88161,Transmembrane helix,0.68603516,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7441813940152228,0.5732274423523478,0.1847585290208241,0.513189448441247,3.1025763486552735,13.0,13.0,5.4274920345926265,5.833912717653736e-10,Cytochrome b559 N-terminal acidic motif,True,assigned_and_evaluated +15023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop/turn scaffolds,False,no_term_above_threshold +15024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ER reticulon domain proteins,False,no_term_above_threshold +15025,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polybasic amphipathic membrane tethers,False,no_term_above_threshold +15026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ribose-phosphate cofactor pockets,False,no_term_above_threshold +15027,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Thiolase-fold condensing enzymes,False,no_term_above_threshold +15028,64585,21.118177,0.98535156,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.9628906,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,0.0,14.0,0.0,1.0,Membrane active amphipathic segments,True,assigned_too_few_test_positives +15029,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory IDRs flanking sensor/DNA modules,False,no_term_above_threshold +15030,59224,36.15757,0.9794922,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9794922,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,20.0,20.0,137.37557603686636,1.3818410501239142e-42,Alpha/beta-hydrolase nucleophile elbow,True,assigned_and_evaluated +15031,64475,16.132729,0.97265625,ACP-like superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.953125,45,ip,IPR036736,interpro:ip:IPR036736,13.0,2257.0,0.9927327574386398,0.3423738261313388,0.0057598582188746125,0.6153846153846154,59.441363506033206,0.0,20.0,0.0,1.0,GXSXG nucleophile elbow,True,assigned_and_evaluated +15032,85762,28.218712,0.8027344,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.7939453,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,17.0,205.58965517241379,2.315081843097633e-39,Rossmann β1–α1 dinucleotide motif,True,assigned_too_few_test_positives +15033,55054,17.427326,0.85009766,HAD superfamily,interpro,55054,HAD superfamily,0.85009766,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.878019538188277,0.04170286306328482,0.002215330084182543,,18.82467238676677,0.0,18.0,0.0,1.0,PIN/NYN beta-strand-loop-helix submotif,True,assigned_and_evaluated +15034,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic pocket/interface hotspots,False,no_term_above_threshold +15035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic alpha helix,False,no_term_above_threshold +15036,36091,25.120625,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,GNAT active-site helix,True,assigned_too_few_test_positives +15037,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic TAD-like IDRs,False,no_term_above_threshold +15038,85364,21.448795,0.77734375,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.77734375,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,15.0,16.0,282.29640151515156,3.4498713320022935e-36,iGluR S2 VTIGSG motif,True,assigned_too_few_test_positives +15039,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HisKA DHp helix activation,False,no_term_above_threshold +15040,87326,34.12262,0.72558594,Coiled coil,keyword,87326,Coiled coil,0.72558594,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7281085451303951,0.26924570659597924,0.03943287549844927,0.20224719101123595,6.8279501099676985,18.0,19.0,11.943973912366028,6.647492796621427e-19,Extended amphipathic helical rods,True,assigned_and_evaluated +15041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich flexible P-loop motifs,False,no_term_above_threshold +15042,85682,28.994068,0.73583984,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.73583984,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.7091218637992832,0.15451957291895158,0.011076650420912717,0.12,13.950027043122947,11.0,15.0,74.99496855345912,2.393435586479521e-19,Rossmann dehydrogenase C-terminal lobe,True,assigned_and_evaluated +15043,82029,24.875732,0.99902344,MFS general substrate transporter like domains,gene3d,88162,Transport,0.62109375,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,15.0,19.0,148.48331396314128,8.230953134921065e-31,MFS intracellular helix-cap hinges,True,assigned_too_few_test_positives +15044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity catalytic motifs,False,no_term_above_threshold +15045,49061,25.426514,0.6801758,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.6801758,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.8556848042043197,0.6726244484323305,0.012405848471422242,0.7142857142857143,54.21833500399178,11.0,18.0,60.42297770407223,7.634357412954402e-18,Ligand binding beta strand scaffolds,True,assigned_and_evaluated +15046,30795,16.23992,0.76220703,rRNA binding,go_mf,88022,Ribosomal protein,0.70654297,78,go,GO:0019843,go_mf:go:GO:0019843,,,,,,,,3.0,17.0,33.507493443237166,0.0001698526289640085,uS3 C-terminal RNA-binding motif,True,assigned_too_few_test_positives +15047,88160,15.946402,0.875,Transmembrane beta strand,keyword,88160,Transmembrane beta strand,0.875,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,18.0,18.0,289.42233009708735,4.0738218914291243e-44,Outer membrane beta-barrel strands,True,assigned_too_few_test_positives +15048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain boundary amphipathic helices,False,no_term_above_threshold +15049,58239,23.48327,0.6142578,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6142578,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6459291835814164,0.2270178568334306,0.017722640673460344,0.225,12.809482571826322,14.0,14.0,35.851473241130485,4.487319221459063e-22,NTPase motor switch/coupling segment,True,assigned_and_evaluated +15050,59229,36.011833,0.8676758,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.8676758,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8203067221984353,0.44993716951674034,0.0101905183872397,0.6086956521739131,44.15253006953404,18.0,18.0,106.27629233511585,1.4850343564104726e-36,Adenine MTase catalytic β-strand–helix,True,assigned_and_evaluated +15051,36914,21.338749,0.8618164,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.7792969,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,1.0,9.0,81.78463648834018,0.020682119121734663,Glycan elongating glycosyltransferase regions,True,assigned_too_few_test_positives +15052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic beta-rich surface segments,False,no_term_above_threshold +15053,50806,19.653831,0.8261719,"Homeobox, conserved site",interpro,87384,DNA-binding,0.6015625,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,N-terminal disordered low-complexity tail,True,assigned_too_few_test_positives +15054,36091,28.243118,0.96777344,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.92041016,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,HATPase_c helical Leu site,True,assigned_too_few_test_positives +15055,38317,23.083607,1.0,Pentatricopeptide repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.91015625,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,10.0,10.0,384.6516129032258,3.3242025682230393e-26,PPR/mTERF helical repeat cores,True,assigned_and_evaluated +15056,36091,19.002466,0.9868164,GNAT domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9453125,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,8.0,0.0,1.0,Helix-packing hydrophobic residues,True,assigned_too_few_test_positives +15057,88263,17.728771,0.61376953,Zinc-finger,keyword,88263,Zinc-finger,0.61376953,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.5887426422498365,0.028633853797042117,0.014621178555604785,,1.95838206120982,0.0,14.0,0.0,1.0,Helical interaction scaffolds,True,assigned_and_evaluated +15058,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad acyl-enzyme N-terminal activation,False,no_term_above_threshold +15059,45324,22.843126,0.9370117,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9370117,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.49622557726465366,0.002215330084182543,0.002215330084182543,,1.0,16.0,16.0,546.9816513761467,8.086221761424609e-44,Extracellular C-terminal linker activation,True,assigned_and_evaluated +15060,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic N-terminal soluble domains,False,no_term_above_threshold +15061,49116,25.327715,0.9819336,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.9819336,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,19.0,19.0,87.03795620437957,6.605101239071875e-37,HEAT/ARM alpha-solenoid core helices,True,assigned_and_evaluated +15062,64058,20.7613,0.6826172,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.6821289,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.7352716387491243,0.06535339122759162,0.006202924235711121,,10.53590028576245,12.0,16.0,85.49856596558317,8.810428908844362e-22,N-terminal Rossmann-like initiation module,True,assigned_and_evaluated +15063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleic acid binding helical arms,False,no_term_above_threshold +15064,48241,16.15205,0.92089844,RmlC-like jelly roll fold,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.7026367,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,1.0,9.0,43.016594516594516,0.0386076117710189,ABC NBD catalytic interface motifs,True,assigned_too_few_test_positives +15065,52236,19.485762,0.99560547,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9892578,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR alpha-solenoid packing residues,True,assigned_too_few_test_positives +15066,87326,33.643948,0.66552734,Coiled coil,keyword,87326,Coiled coil,0.66552734,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6688917450972263,0.2721731176892733,0.03943287549844927,0.33707865168539325,6.902187939603258,18.0,19.0,11.943973912366028,6.647492796621427e-19,Charged coiled-coil tethers,True,assigned_and_evaluated +15067,49045,18.262552,0.97998047,Kelch-type beta propeller,interpro,63831,F-box-like domain superfamily,0.90283203,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,10.0,19.0,285.267942583732,7.698460440975105e-23,Plant SCF substrate receptors,True,assigned_too_few_test_positives +15068,38317,18.311913,0.8745117,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.8745117,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.586095238095238,0.004533171520055597,0.0031014621178555605,,1.4616240172522117,0.0,17.0,0.0,1.0,Fungal KS3 STxANDKNES motif,True,assigned_and_evaluated +15069,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal secretory propeptides,False,no_term_above_threshold +15070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pepsin-like aspartic protease motif,False,no_term_above_threshold +15071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane beta-barrels,False,no_term_above_threshold +15072,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small-residue alpha-helix motifs,False,no_term_above_threshold +15073,55053,23.17634,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,11.0,11.0,552.0462962962963,1.580946100244615e-30,NRPS condensation domain signature,True,assigned_too_few_test_positives +15074,45324,28.073202,0.99853516,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.99853516,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9982238010657193,0.4034920634920635,0.002215330084182543,1.0,182.13631746031749,7.0,18.0,212.7150866462793,4.11229353381945e-15,Beta-solenoid/RTX strand-turn repeats,True,assigned_and_evaluated +15075,45290,19.032873,0.6875,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.6875,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6832579185520362,0.04832474791491185,0.0057598582188746125,,8.389919695688926,17.0,18.0,69.34571702244116,1.1231297419159899e-30,C-terminal helical kinase interfaces,True,assigned_and_evaluated +15076,36914,26.291914,0.99658203,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9609375,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,1.0,15.0,49.07078189300412,0.03400152705684686,Glycosyltransferase specificity loops,True,assigned_too_few_test_positives +15077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-family sensory domains,False,no_term_above_threshold +15078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich TM helices and cores,False,no_term_above_threshold +15079,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic mucin-like low-complexity linkers,False,no_term_above_threshold +15080,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rieske oxygenase catalytic domain,False,no_term_above_threshold +15081,61392,25.418922,0.82177734,Leucine-rich repeat domain superfamily,interpro,63831,F-box-like domain superfamily,0.79003906,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.7113650793650793,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,12.0,12.0,167.4747191011236,5.548442140483082e-27,LRR solenoid domain detector,True,assigned_and_evaluated +15082,37430,19.961899,0.8520508,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,0.8408203,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,0.0,8.0,0.0,1.0,ABC NBD RALAN motif,True,assigned_too_few_test_positives +15083,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trp-rich structured domain cores,False,no_term_above_threshold +15084,58239,32.323837,0.7421875,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7421875,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8104194857916103,0.24523945785514603,0.017722640673460344,0.025,13.837636409476616,14.0,14.0,35.851473241130485,4.487319221459063e-22,Conserved phosphate-positioning beta-loop,True,assigned_and_evaluated +15085,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAC β-strand aromatic-Arg motif,False,no_term_above_threshold +15086,38317,20.585396,0.9453125,Pentatricopeptide repeat,interpro,88161,Transmembrane helix,0.66748047,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9150476190476191,0.0197623381066658,0.0031014621178555605,,6.371942443820672,0.0,18.0,0.0,1.0,Transmembrane helix boundary motifs,True,assigned_and_evaluated +15087,63960,35.351025,0.85595703,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.85595703,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,Rossmann NAD(P)-binding helix,True,assigned_too_few_test_positives +15088,64003,27.077276,0.9770508,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.9746094,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9991597469355477,0.7949514991181659,0.003987594151528578,1.0,199.3561703899667,6.0,15.0,52.184682713347925,1.906019906878945e-09,Interdomain linkers near ZnF/C2,True,assigned_and_evaluated +15089,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short charged amphipathic interfaces,False,no_term_above_threshold +15090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic TM interface cap,False,no_term_above_threshold +15091,31094,18.939754,0.9790039,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.84033203,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,1.0,0.9999999999999999,0.004430660168365086,1.0,225.7,5.0,18.0,197.15939153439155,8.820646845095619e-11,Acyl thioester processing domains,True,assigned_and_evaluated +15092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Substrate binding surface elements,False,no_term_above_threshold +15093,49121,16.572437,0.80810547,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.80810547,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,15.0,0.0,1.0,Sensor-output coupling helices,True,assigned_too_few_test_positives +15094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory cap subdomain,False,no_term_above_threshold +15095,59229,15.746266,0.60546875,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.60546875,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.6899497878634541,0.10600253631680528,0.0101905183872397,,10.40207497682737,10.0,16.0,66.42268270944741,9.245789420152488e-17,Substrate recognition and assembly interfaces,True,assigned_and_evaluated +15096,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TBDR beta-barrel surface loops,False,no_term_above_threshold +15097,58239,18.49658,0.7182617,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7182617,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7927943166441138,0.15923383700571547,0.017722640673460344,,8.984769253047496,0.0,18.0,0.0,1.0,Motif-flanking capping segments,True,assigned_and_evaluated +15098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic c-type cytochrome modules,False,no_term_above_threshold +15099,50338,19.640661,0.8417969,"GPCR, rhodopsin-like, 7TM",interpro,50338,"GPCR, rhodopsin-like, 7TM",0.8417969,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,14.0,0.0,1.0,Metal-assisted phosphate-binding cores,True,assigned_too_few_test_positives +15100,36914,28.822851,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.875,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,18.0,654.2770919067215,7.094834976616662e-44,Glycosyltransferase active site motifs,True,assigned_too_few_test_positives +15101,37640,23.38442,0.87841797,EF-hand domain,interpro,37640,EF-hand domain,0.87841797,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,12.0,0.0,1.0,ABC NBD beta1 strand,True,assigned_too_few_test_positives +15102,58239,16.42531,0.7114258,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7114258,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8370489400090213,0.06810259274400382,0.017722640673460344,,3.8426887955804157,2.0,18.0,3.983497026792276,0.1438837670984963,Active-site loop motifs,True,assigned_and_evaluated +15103,49116,21.980017,0.8774414,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8774414,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8953374777975134,0.42330020887397934,0.002215330084182543,0.2,191.07771428571428,12.0,19.0,54.97134076066077,5.701372624473585e-19,Eukaryotic helical scaffolds and linkers,True,assigned_and_evaluated +15104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma factor N-terminal leaders,False,no_term_above_threshold +15105,87108,23.777554,0.80810547,ANK repeat,keyword,64507,Ankyrin repeat-containing domain superfamily,0.8027344,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.8171461051799129,0.05803595047478321,0.003987594151528578,,14.554126691287301,2.0,20.0,16.93778409090909,0.010564502413606408,Leucine-rich repeat scaffold detector,True,assigned_and_evaluated +15106,87413,53.328884,0.9033203,Disulfide bond,keyword,87413,Disulfide bond,0.9033203,1661,keywords,Disulfide bond,keyword:keywords:Disulfide bond,162.0,2257.0,0.9342894605026666,0.5739155420037715,0.0717766947275144,0.8518518518518519,7.995848014213038,17.0,18.0,11.17014922083361,2.2830004244193644e-17,Mature bioactive peptide detector,True,assigned_and_evaluated +15107,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cys/His metal-binding motifs,False,no_term_above_threshold +15108,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Reverse transcriptase polymerase core,False,no_term_above_threshold +15109,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic stacking catalytic pocket,False,no_term_above_threshold +15110,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor transmembrane helix,False,no_term_above_threshold +15111,25167,15.686456,0.6855469,cell outer membrane,go_cc,25167,cell outer membrane,0.6855469,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.7857646622123237,0.2633868276687236,0.005316792202038104,0.3333333333333333,49.53867250402576,20.0,20.0,136.43249427917618,1.5446348002941576e-42,TonB-dependent β-barrel signature,True,assigned_and_evaluated +15112,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic helical scaffold residues,False,no_term_above_threshold +15113,37020,19.567022,0.9980469,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.94433594,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,17.0,17.0,816.7260273972603,3.4794486095487155e-49,Glycosyltransferase PSX[E] loop motif,True,assigned_too_few_test_positives +15114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-wide non-active-site signal,False,no_term_above_threshold +15115,87326,27.612373,0.6152344,Coiled coil,keyword,87326,Coiled coil,0.6152344,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.5773897135038766,0.14717419726309722,0.03943287549844927,0.1348314606741573,3.7322714968855104,20.0,20.0,12.607528018608585,2.588537742907653e-22,Long coiled-coil scaffolds,True,assigned_and_evaluated +15116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Threonine synthase and PheRSβ motifs,False,no_term_above_threshold +15117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-FHA aromatic-hydrophobic motif,False,no_term_above_threshold +15118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic aromatic surface patch,False,no_term_above_threshold +15119,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal HK catalytic alpha-helix,False,no_term_above_threshold +15120,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DAGKc catalytic core,False,no_term_above_threshold +15121,29104,25.294111,0.7993164,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.79248047,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,11.0,11.0,428.9280575539568,2.68532943002915e-29,TM helices and helix-loop junctions,True,assigned_too_few_test_positives +15122,45272,16.852097,0.9658203,"Lambda repressor-like, DNA-binding domain superfamily",interpro,64146,Winged helix-like DNA-binding domain superfamily,0.94189453,63,ip,IPR010982,interpro:ip:IPR010982,,,,,,,,0.0,13.0,0.0,1.0,Pre-recognition-helix hinge residue,True,assigned_too_few_test_positives +15123,36535,20.851425,0.95996094,Protein kinase domain,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.8847656,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9439697374276813,0.4065201884987578,0.004430660168365086,0.5,91.75160654416965,0.0,7.0,0.0,1.0,SDR YXXXK-flanking helices,True,assigned_and_evaluated +15124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal accessory domains and tails,False,no_term_above_threshold +15125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-proximal primase substrate-binding module,False,no_term_above_threshold +15126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH12 C-terminal β-strand,False,no_term_above_threshold +15127,55054,32.073135,1.0,HAD superfamily,interpro,55054,HAD superfamily,1.0,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8976465364120781,0.6647287803025508,0.002215330084182543,0.8,300.05857142857144,11.0,15.0,245.62958801498127,5.01253309192627e-25,Cap-centric HAD-like domain,True,assigned_and_evaluated +15128,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical packing modules,False,no_term_above_threshold +15129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SBP N-lobe hinge motif,False,no_term_above_threshold +15130,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil scaffolds and acidic tails,False,no_term_above_threshold +15131,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Regulatory domains in membrane transporters,False,no_term_above_threshold +15132,37894,20.652252,0.99316406,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.9458008,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,16.0,0.0,1.0,FAD-binding β1 pyrophosphate segment,True,assigned_too_few_test_positives +15133,81685,21.760494,0.96191406,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9350586,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9561989606533036,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,12.0,12.0,85.66235632183908,1.67612287920582e-23,Kinase N-lobe hydrophobic beta-strand,True,assigned_and_evaluated +15134,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NlpC/P60 catalytic His patch,False,no_term_above_threshold +15135,88263,29.593687,0.8066406,Zinc-finger,keyword,88263,Zinc-finger,0.8066406,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.7934039132330499,0.12759092261177565,0.014621178555604785,0.06060606060606061,8.726445828326595,6.0,17.0,9.19698683669272,5.039593946178037e-05,C-terminal tails and helices,True,assigned_and_evaluated +15136,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic adhesion and metal-binding loops,False,no_term_above_threshold +15137,87276,30.499483,0.6088867,Cell membrane,keyword,87276,Cell membrane,0.6088867,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7391907941514103,0.4568807102962598,0.11120957022596367,0.5099601593625498,4.108285908918957,4.0,12.0,2.7351591889164144,0.08039232926935372,Final transmembrane helix and tail,True,assigned_and_evaluated +15138,37446,18.79596,0.9584961,F-box domain,interpro,43624,Homedomain-like superfamily,0.87158203,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.9862857142857142,0.17973485868706457,0.0031014621178555605,,57.95165372238639,0.0,17.0,0.0,1.0,Loop-to-helix N-cap residues,True,assigned_and_evaluated +15139,52941,20.686571,0.99902344,Major facilitator superfamily domain,interpro,25079,plasma membrane,0.60839844,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,17.0,17.0,260.353711790393,4.679078553617228e-41,MFS small-residue packing faces,True,assigned_too_few_test_positives +15140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting signal detector,False,no_term_above_threshold +15141,48883,23.929049,0.97802734,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.97802734,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,13.0,13.0,480.8145161290322,3.7255170365673266e-35,PLP active-site lid loop,True,assigned_too_few_test_positives +15142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anchor helices and regulatory loops,False,no_term_above_threshold +15143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix entry region,False,no_term_above_threshold +15144,85762,25.996855,0.9375,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9296875,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,17.0,18.0,194.16800766283524,3.6564997752166336e-38,FAD-proximal β-loop-β motif,True,assigned_too_few_test_positives +15145,36409,15.747901,0.9140625,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.9140625,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,18.0,0.0,1.0,WW and Tyr/Trp microdomains,True,assigned_too_few_test_positives +15146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Subtilase active-site core segment,False,no_term_above_threshold +15147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,β-strand termini and P-loop,False,no_term_above_threshold +15148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure caps and linkers,False,no_term_above_threshold +15149,84753,21.581957,0.7817383,3.30.420.40,gene3d,84753,3.30.420.40,0.7817383,40,gene3d,3.30.420.40,gene3d:gene3d:3.30.420.40,,,,,,,,3.0,17.0,73.06495098039215,1.712604299997132e-05,Hydantoinase/oxoprolinase N-terminal interface motif,True,assigned_too_few_test_positives +15150,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged disordered terminal tails,False,no_term_above_threshold +15151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix-start aromatic anchors,False,no_term_above_threshold +15152,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short flexible capping loops,False,no_term_above_threshold +15153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cyclophilin PPIase active-site loop,False,no_term_above_threshold +15154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alternating-register repeat detector,False,no_term_above_threshold +15155,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich CoA thioester-binding loop,False,no_term_above_threshold +15156,37020,17.46428,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9609375,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,19.0,687.7692862292718,7.07564378350904e-44,Glycosyltransferase His-Trp clamp,True,assigned_too_few_test_positives +15157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended charged accessory segments,False,no_term_above_threshold +15158,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosyltransferase catalytic domain,False,no_term_above_threshold +15159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC permease TM1-loop motif,False,no_term_above_threshold +15160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short targeting signals and linkers,False,no_term_above_threshold +15161,64507,31.945238,0.99365234,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99365234,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9997528667457494,0.9282627865961202,0.003987594151528578,1.0,232.7876788163826,16.0,16.0,165.15512465373962,1.2579241046827118e-35,Ankyrin-adjacent cytosolic IDRs,True,assigned_and_evaluated +15162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse terminal-biased activation,False,no_term_above_threshold +15163,87489,18.980635,0.8623047,GPI-anchor,keyword,88161,Transmembrane helix,0.6816406,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8093333333333335,0.019196271505645908,0.0031014621178555605,,6.189426398320402,0.0,18.0,0.0,1.0,Juxtamembrane low-complexity linkers,True,assigned_and_evaluated +15164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2 beta-sandwich loop junctions,False,no_term_above_threshold +15165,47128,16.379145,0.8232422,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.8232422,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,18.0,19.0,243.4614337568058,4.579681182312055e-42,Extracellular N-linked glycosylation hotspots,True,assigned_too_few_test_positives +15166,87239,17.569263,0.7607422,CF(1),keyword,87239,CF(1),0.7607422,38,keywords,CF(1),keyword:keywords:CF(1),20.0,2257.0,0.9987259722843094,0.7455495272271588,0.008861320336730172,1.0,84.13526414758488,5.0,18.0,223.80255255255256,4.643288599970168e-11,Solvent-exposed edge micro-motifs,True,assigned_and_evaluated +15167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Generic aromatic β-strand motif,False,no_term_above_threshold +15168,36886,17.213795,0.93652344,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7109375,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9249110715873722,0.024780150474164292,0.003544528134692069,,6.991099952523601,0.0,14.0,0.0,1.0,Glycine loop caps and hinges,True,assigned_and_evaluated +15169,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NYN RNase domain-adjacent hotspots,False,no_term_above_threshold +15170,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-catalytic linkers and coiled-coils,False,no_term_above_threshold +15171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WWDxG periplasmic loop motif,False,no_term_above_threshold +15172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered extracellular propeptide activation,False,no_term_above_threshold +15173,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal soluble regions,False,no_term_above_threshold +15174,84152,18.767555,0.9506836,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.9506836,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,13.0,0.0,1.0,CAZyme catalytic-domain hotspot,True,assigned_too_few_test_positives +15175,42974,16.675806,0.9423828,"Serine/threonine-protein kinase, active site",interpro,45290,Protein kinase-like domain superfamily,0.82421875,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9990476190476191,0.8041950113378684,0.0031014621178555605,0.8571428571428571,259.2954486556527,1.0,15.0,8.87217261904762,0.17278815451843654,PAS/GAF β-edge micro-motif,True,assigned_and_evaluated +15176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil interfaces,False,no_term_above_threshold +15177,85649,30.728056,0.98291016,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9794922,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.861430072788136,0.7393733719464296,0.0101905183872397,0.7391304347826086,72.55503045578659,16.0,16.0,110.61410018552876,7.117153535323136e-33,Class I SAM MTase core,True,assigned_and_evaluated +15178,59224,34.21245,0.97216797,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.97216797,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,1.0,1.0,0.0031014621178555605,1.0,322.42857142857144,19.0,19.0,137.37557603686636,1.4828928465544412e-40,Alpha/beta-hydrolase nucleophile elbow,True,assigned_and_evaluated +15179,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TROVE-domain helical RNP scaffolds,False,no_term_above_threshold +15180,83419,18.496073,0.9814453,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9707031,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,11.0,18.0,222.164972899729,4.473633068814738e-24,Extracellular Trp-anchored glycan-binding motifs,True,assigned_too_few_test_positives +15181,50806,20.595467,0.9946289,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9790039,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,DNA-contact residue detector,True,assigned_too_few_test_positives +15182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor cap,False,no_term_above_threshold +15183,87326,27.653675,0.69677734,Coiled coil,keyword,87326,Coiled coil,0.69677734,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.707688958912061,0.14750953353849844,0.03943287549844927,,3.7407754741167527,3.0,19.0,1.9906623187276713,0.2967346664983826,Transmembrane and coiled-coil helices,True,assigned_and_evaluated +15184,37430,22.269928,1.0,"Signal transduction response regulator, receiver domain",interpro,37430,"Signal transduction response regulator, receiver domain",1.0,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,REC-centered two-component signaling,True,assigned_too_few_test_positives +15185,36886,20.275867,0.8676758,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.8676758,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.7730380168963984,0.023493579881212485,0.003544528134692069,,6.628126223987072,0.0,14.0,0.0,1.0,Catalytic-core acidic/glycine motifs,True,assigned_and_evaluated +15186,59229,35.520336,0.98339844,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.98339844,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8637849830680004,0.7417888308836276,0.0101905183872397,0.7391304347826086,72.79206049149336,17.0,17.0,106.27629233511585,1.3819031749869367e-34,Post-motif I helix N-cap,True,assigned_and_evaluated +15187,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted CAZyme catalytic domains,False,no_term_above_threshold +15188,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA repair accessory C-termini,False,no_term_above_threshold +15189,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic disordered RGG His/Cys hotspots,False,no_term_above_threshold +15190,52236,20.189268,0.9165039,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.9067383,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,7.0,18.0,86.83874323761964,2.237375140136008e-12,TPR-like inter-repeat coils,True,assigned_too_few_test_positives +15191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transmembrane helices,False,no_term_above_threshold +15192,45804,17.431429,0.81347656,Major facilitator superfamily,interpro,82029,MFS general substrate transporter like domains,0.78222656,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,0.0,15.0,0.0,1.0,Selected hydrophobic TM helix cores,True,assigned_too_few_test_positives +15193,88058,26.99846,0.6645508,Signal,keyword,88058,Signal,0.6645508,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6358418578671072,0.1148464886407509,0.09127159946832078,,1.2582938100105572,1.0,20.0,0.3602477341389728,1.0,Basic-rich disordered low-complexity tails,True,assigned_and_evaluated +15194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short C-terminal substrate-binding motif,False,no_term_above_threshold +15195,87882,16.350046,0.75439453,Palmitate,keyword,88058,Signal,0.70214844,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9706056567451503,0.12392975598199478,0.002658396101019052,,46.618243208560365,1.0,17.0,3.91856720341768,0.35698096395902873,Secreted/periplasmic soluble proteins,True,assigned_and_evaluated +15196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16 presequence protease C-terminal motif,False,no_term_above_threshold +15197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV sensory helical cap,False,no_term_above_threshold +15198,88058,23.053461,0.6425781,Signal,keyword,88058,Signal,0.6425781,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6048612327398901,0.10450261398584958,0.09127159946832078,,1.1449631056604976,3.0,20.0,1.0807432024169183,0.8334769282943363,Disordered low-complexity micropeptides,True,assigned_and_evaluated +15199,63960,27.835447,0.8540039,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.8540039,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,12.0,16.0,145.1810064935065,1.5482731929699041e-24,Rossmann NAD(P)H-binding core,True,assigned_too_few_test_positives +15200,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic membrane helices,False,no_term_above_threshold +15201,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic disordered transactivation tails,False,no_term_above_threshold +15202,46078,20.298817,0.9526367,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.9433594,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,20.0,20.0,130.74780701754386,3.562107146682396e-42,HEAT/ARM alpha-solenoid scaffold,True,assigned_too_few_test_positives +15203,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory β-rich anion-binding interfaces,False,no_term_above_threshold +15204,36104,16.622732,0.95166016,Rho GTPase-activating protein domain,interpro,88161,Transmembrane helix,0.6035156,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,15.0,0.0,1.0,Transmembrane alpha helices,True,assigned_too_few_test_positives +15205,37430,26.102913,0.99902344,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,0.98291016,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,19.0,19.0,484.7235772357723,2.572132453150849e-50,REC α1/β1 hydrophobic patch,True,assigned_too_few_test_positives +15206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent pocket-lining scaffolds,False,no_term_above_threshold +15207,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic helical scaffolds,False,no_term_above_threshold +15208,88161,51.001842,0.67626953,Transmembrane helix,keyword,88159,Transmembrane,0.67333984,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7459519341048899,0.5643992752364558,0.1847585290208241,0.5899280575539568,3.054794158773815,16.0,16.0,5.4274920345926265,3.815160537588821e-12,Alpha-helical transmembrane segments,True,assigned_and_evaluated +15209,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PST-rich phospho-regulatory IDRs,False,no_term_above_threshold +15210,72011,17.677895,0.9033203,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9033203,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,FAD/NAD(P)H reductase catalytic core,True,assigned_too_few_test_positives +15211,64148,21.326052,0.67041016,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.65771484,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.671605286675133,0.2103669175153213,0.008418254319893664,0.2631578947368421,24.98937541221475,10.0,20.0,44.49328358208955,1.1639124928358478e-14,Domain boundary amphipathic interface helix,True,assigned_and_evaluated +15212,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidase active-site rim segments,False,no_term_above_threshold +15213,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-basic strand-edge motif,False,no_term_above_threshold +15214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-alpha junction N-cap motif,False,no_term_above_threshold +15215,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered terminal tails,False,no_term_above_threshold +15216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Archaeal GARS K/R/E-rich tail,False,no_term_above_threshold +15217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC/AAA+ ATPase NBDs,False,no_term_above_threshold +15218,48883,20.874058,0.88671875,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.88671875,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,17.0,17.0,480.8145161290322,1.9646171897949307e-45,PLP fold-I aminotransferase core,True,assigned_too_few_test_positives +15219,36535,20.485008,0.9667969,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9589844,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9484646194926569,0.8904430660168364,0.004430660168365086,0.9,200.97299999999998,17.0,17.0,89.79066265060241,2.357720211227094e-33,Regulatory kinase activation loop,True,assigned_and_evaluated +15220,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand residue signal,False,no_term_above_threshold +15221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,KRR1 post-KH C-terminal segment,False,no_term_above_threshold +15222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved regulatory domain cores,False,no_term_above_threshold +15223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase CA beta-alpha junction,False,no_term_above_threshold +15224,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved extracellular GSDP motifs,False,no_term_above_threshold +15225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet core hydrophobes,False,no_term_above_threshold +15226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand start marker,False,no_term_above_threshold +15227,85672,31.781826,0.89990234,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.89941406,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8703411876532092,0.12220235592436177,0.01595037660611431,0.027777777777777776,7.661408814480126,10.0,12.0,33.34507829977629,1.348558255545381e-14,Amphipathic motor relay helices,True,assigned_and_evaluated +15228,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scattered noncatalytic micro-motifs,False,no_term_above_threshold +15229,88153,15.850731,0.64404297,Transferase,keyword,87601,Hydrolase,0.63378906,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.620879876740219,0.10772953790970471,0.052724856003544526,,2.0432400593462483,2.0,14.0,1.6207965203207828,0.5518663074747573,Aromatic-acidic anion/glycan grooves,True,assigned_and_evaluated +15230,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interhelical lipid phosphate loops,False,no_term_above_threshold +15231,85675,15.888981,0.94677734,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9248047,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,14.0,17.0,450.4554776038855,7.269594227689697e-36,VWA and acidic IDRs,True,assigned_too_few_test_positives +15232,85675,19.12145,0.93408203,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.9145508,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,17.0,18.0,516.5937818552497,3.251667628033392e-45,Short basic surface helices,True,assigned_too_few_test_positives +15233,47529,24.702555,0.8613281,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.8613281,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.8486724676483712,0.09054872118837426,0.007089056269384138,,12.773028982635044,1.0,19.0,4.06997064646051,0.3452291682492581,Extracellular S/T and G/P-enriched loops,True,assigned_and_evaluated +15234,63960,22.482431,0.72265625,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.72265625,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,13.0,13.0,193.57467532467533,5.448326364573456e-30,Flavoprotein Gly–Pro loop motif,True,assigned_too_few_test_positives +15235,36914,20.769238,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,17.0,736.0617283950618,1.578275049659185e-48,GT-A UDP-sugar binding motif,True,assigned_too_few_test_positives +15236,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory extracellular terminal regions,False,no_term_above_threshold +15237,59229,44.743042,0.97753906,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.97753906,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.865030555447433,0.7368158271893963,0.0101905183872397,0.7391304347826086,72.30405747680292,11.0,11.0,106.27629233511585,1.292489101098087e-22,Class I SAM-binding Rossmann core,True,assigned_and_evaluated +15238,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered ZnF-flanking tails,False,no_term_above_threshold +15239,37312,19.484417,0.91308594,"DNA-binding HTH domain, TetR-type",interpro,37312,"DNA-binding HTH domain, TetR-type",0.91308594,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,8.0,0.0,1.0,Acidic/polar coiled-coil helices,True,assigned_too_few_test_positives +15240,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-strand recognition modules,False,no_term_above_threshold +15241,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-associated NAD(P)H oxidoreductases,False,no_term_above_threshold +15242,49236,17.894403,0.95947266,C-type lectin fold,interpro,49236,C-type lectin fold,0.95947266,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,1.0,1.0,0.002215330084182543,1.0,451.40000000000003,18.0,18.0,542.0090909090909,9.077238758683182e-49,C-type lectin WIGL core,True,assigned_and_evaluated +15243,47717,16.899153,0.94140625,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.62597656,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,16.0,239.30447247706422,2.583390169633023e-32,C-terminal HELICc hotspot,True,assigned_too_few_test_positives +15244,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Redox cofactor anchoring modules,False,no_term_above_threshold +15245,36535,17.053625,0.95410156,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.875,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9918558077436582,0.44735211590722923,0.004430660168365086,0.3,100.96737256026165,19.0,19.0,89.79066265060241,3.7420828801112705e-37,Internal kinase domain activation,True,assigned_and_evaluated +15246,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PLP-biased N-terminal transit detector,False,no_term_above_threshold +15247,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNAP large-subunit signature,False,no_term_above_threshold +15248,38317,18.881384,0.9536133,Pentatricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.85009766,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9535873015873017,0.03726286338086207,0.0031014621178555605,,12.014611807229384,0.0,10.0,0.0,1.0,Conserved structural micro-motifs,True,assigned_and_evaluated +15249,8138,16.324478,0.77246094,translation,go_bp,88022,Ribosomal protein,0.7294922,187,go,GO:0006412,go_bp:go:GO:0006412,41.0,2257.0,0.940372677643744,0.1688975215842873,0.018165706690296855,,9.297602590627719,5.0,18.0,28.652921953094964,1.2528026224074945e-06,Ordered KH-domain secondary structure,True,assigned_and_evaluated +15250,36010,19.640476,0.99658203,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.96875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,18.0,18.0,509.58119658119665,2.3458872067348707e-48,alpha/beta hydrolase cap/lid loop,True,assigned_too_few_test_positives +15251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich aromatic nucleotide-binding loops,False,no_term_above_threshold +15252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophilic low-complexity IDRs,False,no_term_above_threshold +15253,46277,17.30714,0.7338867,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.7338867,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.8104913786124828,0.32817919047427246,0.004873726185201595,0.36363636363636365,67.33640299094846,5.0,11.0,85.49039288786922,3.787881784662435e-09,Basic N-terminal amphipathic appendages,True,assigned_and_evaluated +15254,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2/C2-like PIP docking surfaces,False,no_term_above_threshold +15255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-rich C-terminal tails,False,no_term_above_threshold +15256,52940,16.954172,1.0,"AMP-binding, conserved site",interpro,69093,"ANL, N-terminal domain",0.9736328,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,13.0,17.0,465.2298919567827,3.0385296915232947e-33,ANL C-terminal subdomain,True,assigned_too_few_test_positives +15257,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phycobilisome linker repeat motif,False,no_term_above_threshold +15258,87149,23.774616,0.76953125,Amphibian defense peptide,keyword,88161,Transmembrane helix,0.68603516,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.831570851759277,0.14592571362751602,0.012405848471422242,,11.762654844903702,0.0,19.0,0.0,1.0,Lipid-binding amphipathic IDRs,True,assigned_and_evaluated +15259,85664,16.209124,0.9760742,Glycogen Phosphorylase B;,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.9169922,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase helix C-cap motif,True,assigned_too_few_test_positives +15260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered HGT-associated segments,False,no_term_above_threshold +15261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular catalytic serine loop,False,no_term_above_threshold +15262,36499,23.29858,0.9189453,"Zinc finger, GATA-type",interpro,36499,"Zinc finger, GATA-type",0.9189453,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,15.0,0.0,1.0,V/A-ATPase subunit d/C marker,True,assigned_too_few_test_positives +15263,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aspartyl protease catalytic core,False,no_term_above_threshold +15264,85364,15.606882,0.9819336,Periplasmic binding protein-like II,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.8417969,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,7.0,17.0,123.98900772430184,1.7071517739008324e-13,Asp-centered acidic catalytic motifs,True,assigned_too_few_test_positives +15265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC signature glycine motif,False,no_term_above_threshold +15266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic oxyanion-binding loops,False,no_term_above_threshold +15267,87882,37.590046,0.88427734,Palmitate,keyword,87882,Palmitate,0.88427734,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9984451354953354,0.6194444444444445,0.002658396101019052,0.8333333333333334,233.01435185185184,18.0,19.0,63.10955601293737,9.917200624158424e-32,Periplasmic post-cleavage N-terminus,True,assigned_and_evaluated +15268,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured soluble domain cores,False,no_term_above_threshold +15269,63831,15.908224,0.7421875,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.7421875,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.4731230564193692,0.002658396101019052,0.002658396101019052,,1.0,0.0,18.0,0.0,1.0,C-terminal helical interaction module,True,assigned_and_evaluated +15270,-1,,,,,-1,,,0,,,,,,,,,,,,,,,LytM/M23 Zn peptidase cores,False,no_term_above_threshold +15271,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short docking helix motif,False,no_term_above_threshold +15272,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Downstream tryptophan SLiM detector,False,no_term_above_threshold +15273,63951,26.795288,0.96777344,Immunoglobulin-like domain superfamily,interpro,63951,Immunoglobulin-like domain superfamily,0.96777344,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9940688018979834,0.25342186257218935,0.003987594151528578,,63.55257153615904,0.0,9.0,0.0,1.0,Ordered mid-domain patches,True,assigned_and_evaluated +15274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged nucleotide-binding catalytic cores,False,no_term_above_threshold +15275,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavin oxidoreductase N-terminal TM1 region,False,no_term_above_threshold +15276,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory interaction helices,False,no_term_above_threshold +15277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease domain catalytic core,False,no_term_above_threshold +15278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding beta-loop motif,False,no_term_above_threshold +15279,87882,39.80481,0.90234375,Palmitate,keyword,88058,Signal,0.6044922,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.998963423663557,0.6265262515262516,0.002658396101019052,0.8333333333333334,235.67829161579164,15.0,16.0,62.45216480446927,1.980391321520189e-26,Post-cleavage N-terminal linker,True,assigned_and_evaluated +15280,64026,16.040144,0.7138672,MFS transporter superfamily,interpro,64026,MFS transporter superfamily,0.7138672,121,ip,IPR036259,interpro:ip:IPR036259,6.0,2257.0,0.9058196357174589,0.2733970526694533,0.002658396101019052,0.3333333333333333,102.84285797915935,4.0,14.0,48.39366883116883,2.1915375759410787e-06,Pore-lining transmembrane segments,True,assigned_and_evaluated +15281,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich disordered linkers,False,no_term_above_threshold +15282,64003,33.682167,0.96875,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.95458984,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,8.0,8.0,130.4617067833698,2.742011657510673e-17,C2H2 recognition helices and linkers,True,assigned_and_evaluated +15283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short α-helical interface motifs,False,no_term_above_threshold +15284,45551,16.456753,0.99560547,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.99560547,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,19.0,0.0,1.0,Cytochrome P450 N-terminal hinge motif,True,assigned_too_few_test_positives +15285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic structural core segments,False,no_term_above_threshold +15286,55053,16.172647,0.80908203,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.80908203,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,18.0,0.0,1.0,Short amphipathic topogenic signals,True,assigned_too_few_test_positives +15287,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho/proline-rich disordered linkers,False,no_term_above_threshold +15288,64620,18.458479,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9423828,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,GHKL N-box E...N motif,True,assigned_too_few_test_positives +15289,87913,15.597978,0.8178711,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.8178711,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.9256098337685499,0.4773070794538897,0.006202924235711121,0.8571428571428571,76.94871988053065,1.0,18.0,26.71191756272401,0.06094622823608961,Hinge/linker and mobile loop residues,True,assigned_and_evaluated +15290,49061,27.49906,0.9951172,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9951172,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.9994231878484907,0.9438468677741281,0.012405848471422242,1.0,76.08079930593597,11.0,19.0,57.24282098280527,1.7848532300770983e-17,Isolated small β-strand residues,True,assigned_and_evaluated +15291,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M14 carboxypeptidase N-terminal surface,False,no_term_above_threshold +15292,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PIN-domain catalytic core segment,False,no_term_above_threshold +15293,29034,19.515762,0.75878906,GTP binding,go_mf,58239,P-loop containing nucleoside triphosphate hydrolase,0.72802734,89,go,GO:0005525,go_mf:go:GO:0005525,20.0,2257.0,0.7168641037103263,0.4498737261852016,0.008861320336730172,0.45,50.76825,11.0,13.0,109.67073578595317,1.0694639343362066e-21,GTPase Switch I loop,True,assigned_and_evaluated +15294,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity linkers,False,no_term_above_threshold +15295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged substrate-binding coiled-coils,False,no_term_above_threshold +15296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic-basic catalytic motif hotspot,False,no_term_above_threshold +15297,37690,31.528912,0.99365234,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.99365234,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9993015873015874,0.7953308596165738,0.0031014621178555605,1.0,256.43739287922955,18.0,18.0,180.66969696969696,1.390790500677779e-40,Ankyrin-repeat start-turn spikes,True,assigned_and_evaluated +15298,87409,18.42554,0.8408203,Dioxygenase,keyword,87409,Dioxygenase,0.8408203,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,12.0,17.0,197.5840927920464,6.033683651792275e-26,N-terminal-biased activation in 2OG oxygenases,True,assigned_too_few_test_positives +15299,46929,17.463806,0.8334961,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.8046875,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9896980461811724,0.19344054319664075,0.002215330084182543,,87.31906119896364,1.0,16.0,5.369326368876081,0.27083747796299695,Ser/Thr/Pro-rich disordered regions,True,assigned_and_evaluated +15300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Zn2Cys6 regulatory helical blocks,False,no_term_above_threshold +15301,37476,20.196302,0.9658203,Pleckstrin homology domain,interpro,37476,Pleckstrin homology domain,0.9658203,36,ip,IPR001849,interpro:ip:IPR001849,5.0,2257.0,0.9987566607460036,0.5053968253968254,0.002215330084182543,1.0,228.136126984127,0.0,20.0,0.0,1.0,Amphipathic oligomerization helices,True,assigned_and_evaluated +15302,45714,17.016445,0.8676758,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.8676758,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,13.0,0.0,1.0,Long amphipathic helices,True,assigned_too_few_test_positives +15303,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble amphipathic alpha-helical scaffolds,False,no_term_above_threshold +15304,36409,34.188477,0.99121094,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.99121094,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,0.0,17.0,0.0,1.0,Lipoyl-like β-sandwich strands,True,assigned_too_few_test_positives +15305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved hydrophobic aromatic motif,False,no_term_above_threshold +15306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded core domain activation,False,no_term_above_threshold +15307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha/beta-hydrolase nucleophile elbow,False,no_term_above_threshold +15308,59237,16.362242,0.9277344,Ubiquitin-like domain superfamily,interpro,59237,Ubiquitin-like domain superfamily,0.9277344,33,ip,IPR029071,interpro:ip:IPR029071,,,,,,,,6.0,18.0,104.5982456140351,3.725925511414539e-11,CIDE C-terminal effector region,True,assigned_too_few_test_positives +15309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal domain-adjacent tails,False,no_term_above_threshold +15310,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Intracellular coupling helices,False,no_term_above_threshold +15311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil dimerization helices,False,no_term_above_threshold +15312,81685,18.462303,0.98291016,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.96972656,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9855605048255383,0.9191604322527014,0.005316792202038104,0.9166666666666666,172.87875796619556,13.0,13.0,85.66235632183908,2.0540243146225536e-25,Kinase DFG-1 site,True,assigned_and_evaluated +15313,36010,16.319283,0.9970703,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.90185547,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,18.0,19.0,482.7611336032389,3.1113490681660496e-47,Aromatic hydrolase lid helix,True,assigned_too_few_test_positives +15314,47529,28.695782,0.9794922,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9794922,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9933623382418564,0.5410144640197831,0.007089056269384138,0.625,76.31685283079067,18.0,19.0,73.25947163628916,7.086927814754248e-33,Extracellular beta-strand adhesion motif,True,assigned_and_evaluated +15315,38654,21.256804,0.83740234,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.83740234,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,14.0,0.0,1.0,Gfo/Idh/MocA C-terminal substrate-binding,True,assigned_too_few_test_positives +15316,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered linkers,False,no_term_above_threshold +15317,85388,15.844663,0.796875,Glutaredoxin,gene3d,85388,Glutaredoxin,0.796875,69,gene3d,3.40.30.10,gene3d:gene3d:3.40.30.10,8.0,2257.0,0.8922854602045354,0.050866143115061116,0.003544528134692069,,14.350610626336618,0.0,20.0,0.0,1.0,β→α junction hinge loops,True,assigned_and_evaluated +15318,27932,25.074036,0.8803711,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.8334961,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9466427720494597,0.3716775917071419,0.01949490474080638,0.022727272727272728,19.06537101097771,10.0,18.0,57.504822530864196,6.377499646578621e-16,Amphipathic N-terminal transit peptides,True,assigned_and_evaluated +15319,64085,25.435112,0.9628906,WD40-repeat-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9448242,130,ip,IPR036322,interpro:ip:IPR036322,28.0,2257.0,0.9968115106069345,0.6700248435113083,0.012405848471422242,1.0,54.008788278750814,8.0,20.0,47.03826429980276,6.486915234925399e-12,N-terminal WD40 beta-propellers,True,assigned_and_evaluated +15320,25169,17.991207,0.7705078,pilus,go_cc,25169,pilus,0.7705078,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.7885435168738899,0.04074607601126405,0.002215330084182543,,18.392778711484596,0.0,16.0,0.0,1.0,Extracellular adhesin beta-strand modules,True,assigned_and_evaluated +15321,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multi-pass transporter TM helices,False,no_term_above_threshold +15322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Death-fold signaling modules,False,no_term_above_threshold +15323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal β-sheet catalytic edge,False,no_term_above_threshold +15324,88058,20.202168,0.6225586,Signal,keyword,88058,Signal,0.6225586,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6000861526226846,0.10272761731992197,0.09127159946832078,,1.12551569073332,1.0,19.0,0.3792081411989187,1.0,Low-complexity disordered segments,True,assigned_and_evaluated +15325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta-sandwich selector,False,no_term_above_threshold +15326,37446,18.088324,0.9326172,F-box domain,interpro,49116,Armadillo-type fold,0.89208984,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.8649523809523809,0.013157415675735668,0.0031014621178555605,,4.242326740019343,0.0,18.0,0.0,1.0,Sparse dispersed residue hotspots,True,assigned_and_evaluated +15327,47529,22.41339,0.93359375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.93359375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9895972780008925,0.45474831710666774,0.007089056269384138,0.25,64.14793448185932,19.0,19.0,77.32944228274968,5.9100056368901175e-36,Ectodomain surface loop patches,True,assigned_and_evaluated +15328,63831,21.984465,0.8720703,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8720703,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9914112246409003,0.7013457556935817,0.002658396101019052,0.6666666666666666,263.822895100069,16.0,19.0,206.61381849685944,1.7979644410518218e-35,F-box adaptor substrate platforms,True,assigned_and_evaluated +15329,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal intrinsically disordered regions,False,no_term_above_threshold +15330,58239,26.07763,0.7192383,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7192383,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.646352052322959,0.15524487460217656,0.017722640673460344,0.175,8.759692049427812,15.0,15.0,35.851473241130485,1.3063198800490947e-23,SF2 helicase ATPase core,True,assigned_and_evaluated +15331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycosyltransferase catalytic-site signature,False,no_term_above_threshold +15332,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Asparaginase/glutaminase catalytic core,False,no_term_above_threshold +15333,45290,20.190102,0.734375,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.734375,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.6009529686000274,0.014185398183972667,0.0057598582188746125,,2.462803361632793,18.0,18.0,73.42487684729065,1.0228110847087699e-33,Kinase active-site helix,True,assigned_and_evaluated +15334,48883,21.736973,0.9814453,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9814453,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,11.0,11.0,480.8145161290322,7.478049958600717e-30,AAT-fold C-terminal element,True,assigned_too_few_test_positives +15335,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular β-sandwich head domains,False,no_term_above_threshold +15336,36977,18.652246,0.9819336,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9580078,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,1.0,18.0,17.25144675925926,0.09279007807139945,MFP periplasmic β-strands; kinase helices,True,assigned_too_few_test_positives +15337,30398,16.365952,0.6557617,ATP hydrolysis activity,go_mf,30398,ATP hydrolysis activity,0.6557617,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6335303165223023,0.2399081644983284,0.004873726185201595,0.2727272727272727,49.22479338842975,10.0,10.0,72.00603864734299,6.39947883854114e-19,ABC NBD helical subdomain,True,assigned_and_evaluated +15338,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HECT E3 catalytic domain,False,no_term_above_threshold +15339,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Moco molybdopterin-binding motif,False,no_term_above_threshold +15340,88160,15.772614,0.8745117,Transmembrane beta strand,keyword,64026,MFS transporter superfamily,0.76416016,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,17.0,18.0,273.3433117583603,1.238197210134836e-40,Lipid-facing OM β-barrel residues,True,assigned_too_few_test_positives +15341,38317,15.653632,0.85058594,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.85058594,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7234285714285713,0.010860318801578695,0.0031014621178555605,,3.501677076451873,0.0,20.0,0.0,1.0,Rad50 C-terminal IxIxIRSDxx motif,True,assigned_and_evaluated +15342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short helix carbohydrate-binding motif,False,no_term_above_threshold +15343,84152,17.075655,0.99902344,Metal-dependent hydrolases,gene3d,59218,Metallo-dependent phosphatase-like,0.96484375,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,17.0,17.0,562.4622641509434,1.3948271210365263e-46,Deaminase catalytic loop motif,True,assigned_too_few_test_positives +15344,50806,17.35112,0.8808594,"Homeobox, conserved site",interpro,87566,Homeobox,0.82714844,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,20.0,0.0,1.0,Outer-membrane beta-barrel extracellular loops,True,assigned_too_few_test_positives +15345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann-like catalytic core,False,no_term_above_threshold +15346,88058,37.10387,0.6455078,Signal,keyword,88058,Signal,0.6455078,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6431494463983943,0.2192462473360612,0.09127159946832078,0.13106796116504854,2.402130001152865,11.0,18.0,4.403027861698557,8.511586651843103e-06,Extracytoplasmic active site loops,True,assigned_and_evaluated +15347,64016,42.71028,0.84814453,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.84814453,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7111111111111111,0.4303436926387746,0.0031014621178555605,0.42857142857142855,138.75510204081633,10.0,10.0,221.63940520446096,8.628605611931638e-24,Strand-helix redox scaffold,True,assigned_and_evaluated +15348,63960,33.86735,0.89990234,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.89990234,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,0.0,13.0,0.0,1.0,Anion transporter cytosolic C-termini,True,assigned_too_few_test_positives +15349,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bioactive secreted peptide cores,False,no_term_above_threshold +15350,63951,23.371223,0.97021484,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9667969,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9977263740608936,0.6167789001122335,0.003987594151528578,0.8888888888888888,154.67444195036788,14.0,14.0,161.13783783783785,3.975102145623941e-31,Proline-rich Ig/FN3 coil loops,True,assigned_and_evaluated +15351,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GH16/GH7 catalytic motif activation,False,no_term_above_threshold +15352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic IDR linear motifs,False,no_term_above_threshold +15353,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fold-I PLP C-terminal helix motif,False,no_term_above_threshold +15354,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC TMD single-helix selector,False,no_term_above_threshold +15355,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane anchors and scaffolds,False,no_term_above_threshold +15356,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble extracytoplasmic carbohydrate interacting domains,False,no_term_above_threshold +15357,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic dCache sensor domain,False,no_term_above_threshold +15358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aliphatic coiled-coil helices,False,no_term_above_threshold +15359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged C-terminal kinase lid helix,False,no_term_above_threshold +15360,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-dense S/T/Q/E-rich IDRs,False,no_term_above_threshold +15361,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil oligomerization helices,False,no_term_above_threshold +15362,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular nuclease domain detector,False,no_term_above_threshold +15363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Formin FH2 helical core,False,no_term_above_threshold +15364,36951,17.263624,0.8808594,SET domain,interpro,36951,SET domain,0.8808594,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,0.0,10.0,0.0,1.0,Cyclophilin PPIase domain activation,True,assigned_too_few_test_positives +15365,85682,17.47031,0.61572266,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.61572266,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.6171594982078853,0.09761239351403285,0.011076650420912717,0.16,8.812446886446885,9.0,15.0,61.359519725557455,8.502129427582305e-15,HAD C-terminal dimerization region,True,assigned_and_evaluated +15366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-VWFA linker motif detector,False,no_term_above_threshold +15367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-rich multi-pass TM helices,False,no_term_above_threshold +15368,84152,20.132507,0.84814453,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.84814453,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,11.0,13.0,475.9296081277213,8.972063948750959e-29,Catalytic core and helical interfaces,True,assigned_too_few_test_positives +15369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic gate-helix linkers,False,no_term_above_threshold +15370,47128,19.388597,0.9296875,Concanavalin A-like lectin/glucanase domain superfamily,interpro,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.9296875,68,ip,IPR013320,interpro:ip:IPR013320,,,,,,,,12.0,15.0,205.5896551724138,1.3015143884801875e-26,Aromatic glycan-binding clamp loop,True,assigned_too_few_test_positives +15371,82029,17.556576,0.9536133,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.83691406,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,14.0,0.0,1.0,Repeat-boundary TM-edge hotspots,True,assigned_too_few_test_positives +15372,37312,16.243528,0.9692383,"DNA-binding HTH domain, TetR-type",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.8178711,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,0.0,19.0,0.0,1.0,HATPase_c hydrophobic helix patch,True,assigned_too_few_test_positives +15373,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting peptides and propeptides,False,no_term_above_threshold +15374,87697,20.0083,0.7651367,Knottin,keyword,87697,Knottin,0.7651367,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.7236595685648888,0.04261413823610577,0.017279574656623838,,2.4661566666382235,0.0,16.0,0.0,1.0,Zn-knuckle/EGF cysteine motif,True,assigned_and_evaluated +15375,37007,27.49209,0.9760742,Metallo-beta-lactamase,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.95703125,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,9.0,18.0,414.03472222222223,4.298872755153726e-22,Charged disordered linkers,True,assigned_too_few_test_positives +15376,87276,42.15547,0.6899414,Cell membrane,keyword,88161,Transmembrane helix,0.6772461,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.801131466159291,0.605055645706587,0.11120957022596367,0.6294820717131474,5.440679650835724,11.0,19.0,4.750539643907457,4.890440005771653e-06,Positive-inside juxtamembrane motifs,True,assigned_and_evaluated +15377,46284,16.965878,0.89404297,FMN-binding split barrel,interpro,87697,Knottin,0.74658203,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,3.0,15.0,238.48400000000004,4.886911968218489e-07,Ligand-binding beta-hairpin loops,True,assigned_too_few_test_positives +15378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal loop-beta-alpha phosphate patch,False,no_term_above_threshold +15379,36354,16.334436,0.97021484,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9633789,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,19.0,0.0,1.0,Glycine-rich strand-coil turns,True,assigned_too_few_test_positives +15380,36449,21.428467,1.0,EamA domain,interpro,36449,EamA domain,1.0,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,14.0,19.0,784.4868421052631,6.146287500115658e-39,Small/hydrophobic TM1 helix face,True,assigned_too_few_test_positives +15381,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conformational coupling interfaces,False,no_term_above_threshold +15382,45804,16.311155,0.9760742,Major facilitator superfamily,interpro,88161,Transmembrane helix,0.62109375,79,ip,IPR011701,interpro:ip:IPR011701,,,,,,,,7.0,17.0,113.65659041394335,3.1392961763619826e-13,Transporter N-terminal transmembrane helices,True,assigned_too_few_test_positives +15383,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting signals,False,no_term_above_threshold +15384,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor TM1 module,False,no_term_above_threshold +15385,64585,20.18714,0.97558594,"Zinc finger, CCCH-type superfamily",interpro,36409,"Zinc finger, CCCH-type",0.9711914,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,6.0,17.0,239.12165775401073,2.383315386818993e-13,Hepadnaviral TP priming domain,True,assigned_too_few_test_positives +15386,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T-rich activation IDRs,False,no_term_above_threshold +15387,81858,18.024818,0.88427734,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.69433594,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,18.0,0.0,1.0,Membrane interface helix caps,True,assigned_too_few_test_positives +15388,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-adjacent flexible linker loops,False,no_term_above_threshold +15389,8972,15.576953,0.69677734,sensory perception of smell,go_bp,8972,sensory perception of smell,0.69677734,25,go,GO:0007608,go_bp:go:GO:0007608,,,,,,,,0.0,18.0,0.0,1.0,Lysozyme-like peptidoglycan hydrolases,True,assigned_too_few_test_positives +15390,64507,35.065563,0.9946289,Ankyrin repeat-containing domain superfamily,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9946289,133,ip,IPR036770,interpro:ip:IPR036770,9.0,2257.0,0.9996045867931989,0.8893738977072312,0.003987594151528578,1.0,223.0352096805801,18.0,18.0,165.15512465373962,6.4988362365136876e-40,Ankyrin repeat N-cap motif,True,assigned_and_evaluated +15391,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic low-complexity NA-binding tails,False,no_term_above_threshold +15392,85682,17.225046,0.62353516,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.62353516,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8758870967741935,0.510988664716359,0.011076650420912717,0.52,46.13205665059289,11.0,15.0,74.99496855345912,2.393435586479521e-19,Ribose-phosphate binding loop,True,assigned_and_evaluated +15393,64058,42.907303,0.82666016,NAD(P)-binding domain superfamily,interpro,64058,NAD(P)-binding domain superfamily,0.82666016,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9626775364626458,0.7548142900309177,0.006202924235711121,0.7857142857142857,121.6868466142701,16.0,16.0,113.99808795411089,4.441314123773332e-33,Glycine-rich Rossmann NAD(P)H loop,True,assigned_and_evaluated +15394,64016,37.389698,0.87646484,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.87646484,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.7811428571428571,0.2472475653974483,0.0031014621178555605,0.5714285714285714,79.71967930029155,17.0,19.0,198.30894149872822,8.860288009731091e-38,Thioredoxin fold domain activation,True,assigned_and_evaluated +15395,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic–aromatic polyanion-binding surface,False,no_term_above_threshold +15396,87545,15.97881,0.77441406,Hemolysis,keyword,87162,Antimicrobial,0.67529297,102,keywords,Hemolysis,keyword:keywords:Hemolysis,8.0,2257.0,0.9811305024455313,0.08887019681825331,0.003544528134692069,,25.072504277349715,0.0,17.0,0.0,1.0,Membrane-active amphipathic segments,True,assigned_and_evaluated +15397,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic strand-loop-helix junctions,False,no_term_above_threshold +15398,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site edge-strand hotspot,False,no_term_above_threshold +15399,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA glycosylase catalytic helix-loop,False,no_term_above_threshold +15400,49236,25.099382,0.9614258,C-type lectin fold,interpro,49236,C-type lectin fold,0.9614258,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.897380106571936,0.6731703387441093,0.002215330084182543,0.6,303.8690909090909,8.0,14.0,309.7194805194805,7.753995063177132e-19,Signal peptide and domain linkers,True,assigned_and_evaluated +15401,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal helical interaction regions,False,no_term_above_threshold +15402,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Omp85/TpsB outer-membrane β-barrel,False,no_term_above_threshold +15403,36914,20.004845,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,18.0,18.0,736.0617283950618,5.020084665387621e-51,Glycosyltransferase UDP-sugar catalytic loop,True,assigned_too_few_test_positives +15404,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short C-terminal enzyme segments,False,no_term_above_threshold +15405,81685,20.844238,0.9663086,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.9423828,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.955957683741648,0.9171097326835033,0.005316792202038104,0.9166666666666666,172.49305555555557,16.0,16.0,85.66235632183908,4.040725274098586e-31,Kinase core alpha-helix hydrophobe,True,assigned_and_evaluated +15406,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic domain-scale scaffolds,False,no_term_above_threshold +15407,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended peripheral binding-region activation,False,no_term_above_threshold +15408,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic phosphate-binding helix,False,no_term_above_threshold +15409,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Macromolecular assembly scaffolds,False,no_term_above_threshold +15410,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal assembly interfaces,False,no_term_above_threshold +15411,85672,15.602138,0.71875,P-loop containing nucleotide triphosphate hydrolases,gene3d,88153,Transferase,0.67285156,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8436952824053229,0.04922783250865696,0.01595037660611431,,3.0863116103344104,2.0,16.0,5.001761744966443,0.09748758712992651,Active-site beta-strand termini,True,assigned_and_evaluated +15412,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site strand-loop motifs,False,no_term_above_threshold +15413,37071,19.17648,0.98291016,Homeodomain,interpro,87384,DNA-binding,0.6254883,78,ip,IPR001356,interpro:ip:IPR001356,,,,,,,,3.0,16.0,38.6814446366782,0.00011047905302577782,Myb/SANT/HTH DNA-binding domain,True,assigned_too_few_test_positives +15414,49121,19.053646,0.9296875,"Signal transduction response regulator, C-terminal effector",interpro,49121,"Signal transduction response regulator, C-terminal effector",0.9296875,25,ip,IPR016032,interpro:ip:IPR016032,,,,,,,,0.0,10.0,0.0,1.0,ABC NBD signature motif,True,assigned_too_few_test_positives +15415,87149,18.513512,0.7578125,Amphibian defense peptide,keyword,87326,Coiled coil,0.6879883,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7466833301288213,0.03340403239432581,0.012405848471422242,,2.6926036112140483,0.0,13.0,0.0,1.0,C-terminal helix-cap alpha-MoRFs,True,assigned_and_evaluated +15416,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helix boundary caps,False,no_term_above_threshold +15417,45324,19.493343,0.8745117,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.8745117,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9994671403197158,0.6861904761904761,0.002215330084182543,1.0,309.74638095238095,6.0,15.0,218.79266055045872,3.58948333574784e-13,Extracellular beta-solenoid repeats,True,assigned_and_evaluated +15418,37341,23.315702,0.99658203,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9921875,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999003487792726,0.9922262922262921,0.011962782454585734,1.0,82.94276820573116,18.0,18.0,145.4170731707317,6.116114472809986e-39,WD40 propeller blade loops,True,assigned_and_evaluated +15419,84991,18.032982,0.9995117,3.30.70.20,gene3d,87681,Iron-sulfur,0.74560547,25,gene3d,3.30.70.20,gene3d:gene3d:3.30.70.20,,,,,,,,11.0,14.0,544.7101328903655,3.784568656336956e-29,Ferredoxin Fe–S electron-transfer modules,True,assigned_too_few_test_positives +15420,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal OMP β-signal,False,no_term_above_threshold +15421,38317,20.696873,1.0,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.8925781,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,14.0,14.0,384.6516129032258,2.020858837444457e-36,PPR/PUF RNA-binding repeats,True,assigned_and_evaluated +15422,61392,21.017864,0.9248047,Leucine-rich repeat domain superfamily,interpro,61392,Leucine-rich repeat domain superfamily,0.9248047,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,0.939936507936508,0.027424325856327602,0.0031014621178555605,,8.842386208247342,0.0,17.0,0.0,1.0,Short hydrophobic beta-strands,True,assigned_and_evaluated +15423,63951,18.941868,0.9086914,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.8066406,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.8744068801897983,0.1605834441103488,0.003987594151528578,,40.27075926189525,0.0,20.0,0.0,1.0,Aromatic β-strand adhesive motifs,True,assigned_and_evaluated +15424,37430,16.068604,1.0,"Signal transduction response regulator, receiver domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.76464844,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,18.0,18.0,484.7235772357723,5.774267819403017e-48,Two-component receiver/kinase motifs,True,assigned_too_few_test_positives +15425,87162,17.906483,0.68408203,Antimicrobial,keyword,24878,extracellular region,0.6616211,669,keywords,Antimicrobial,keyword:keywords:Antimicrobial,56.0,2257.0,0.7569530083728175,0.06575622311382759,0.024811696942844484,,2.65021063514123,0.0,18.0,0.0,1.0,C-terminal helix–tail motif,True,assigned_and_evaluated +15426,45551,18.433239,0.8808594,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.8808594,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,15.0,0.0,1.0,HhH DNA-backbone binding motif,True,assigned_too_few_test_positives +15427,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic coiled-coil helices,False,no_term_above_threshold +15428,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C5 cytosine methyltransferase TIQASGRQ motif,False,no_term_above_threshold +15429,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tubby/CENP-L broad linker activation,False,no_term_above_threshold +15430,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended hydrophobic helical tracts,False,no_term_above_threshold +15431,36535,22.15319,0.9472656,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9243164,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9477970627503337,0.8793319549057255,0.004430660168365086,0.9,198.46522222222225,11.0,11.0,89.79066265060241,8.231873136338666e-22,Kinase C-lobe hydrophobic patch,True,assigned_and_evaluated +15432,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-centered flexible coil motifs,False,no_term_above_threshold +15433,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted GlcNAc-acting hydrolases,False,no_term_above_threshold +15434,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TTLL ATP ligase catalytic core,False,no_term_above_threshold +15435,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic β-loop cofactor-binding module,False,no_term_above_threshold +15436,36104,21.331297,0.97021484,Rho GTPase-activating protein domain,interpro,43538,Rho GTPase activation protein,0.9550781,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,N-terminal catalytic cores,True,assigned_too_few_test_positives +15437,64058,28.704945,0.98291016,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.96533203,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9957327558754219,0.4918559205072171,0.006202924235711121,0.7857142857142857,79.2942008989135,1.0,16.0,7.12488049713193,0.21028084137787656,Alpha-helix start detector,True,assigned_and_evaluated +15438,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad activation of HAT subunits,False,no_term_above_threshold +15439,38317,16.720652,0.8989258,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.7553711,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8213333333333334,0.046108513883961845,0.0031014621178555605,,14.866702262300269,0.0,18.0,0.0,1.0,C-terminal structured domains,True,assigned_and_evaluated +15440,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical assembly segments,False,no_term_above_threshold +15441,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short core beta-strand motifs,False,no_term_above_threshold +15442,47529,29.240139,0.98339844,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.98339844,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9969879518072289,0.6809112260452177,0.007089056269384138,0.9375,96.05103982400352,19.0,20.0,73.46297016861219,1.0504096158872857e-34,Extracellular beta-strand edge motifs,True,assigned_and_evaluated +15443,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded extracytoplasmic soluble domains,False,no_term_above_threshold +15444,59224,16.953745,0.72558594,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.72558594,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.8490793650793651,0.4765395512961148,0.0031014621178555605,0.42857142857142855,153.64996675361874,10.0,10.0,137.37557603686636,1.02382925547944e-21,Alpha/beta-hydrolase catalytic core,True,assigned_and_evaluated +15445,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp active-site loops,False,no_term_above_threshold +15446,87276,35.216213,0.6484375,Cell membrane,keyword,88161,Transmembrane helix,0.6386719,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7322355642236636,0.3745557716070709,0.11120957022596367,0.5099601593625498,3.3680174363233424,12.0,20.0,4.923286540049546,1.0037584863232424e-06,Membrane helix boundary/disruption detector,True,assigned_and_evaluated +15447,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-helix polar loop motif,False,no_term_above_threshold +15448,47529,27.91685,0.99072266,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.99072266,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9975736278447122,0.662446786851779,0.007089056269384138,0.9375,93.44639987027908,16.0,16.0,77.32944228274968,2.0259079421166962e-30,Ig/FN3 strand-entry hotspots,True,assigned_and_evaluated +15449,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Radical SAM glycine-rich loop-helix,False,no_term_above_threshold +15450,49116,22.667288,0.8725586,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.8725586,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.8896092362344582,0.11310082002753169,0.002215330084182543,,51.053710160427805,7.0,20.0,30.463284671532847,3.5692924255489503e-09,Nuclear alpha-helical scaffolds,True,assigned_and_evaluated +15451,64146,15.700643,0.77978516,Winged helix-like DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.77978516,275,ip,IPR036388,interpro:ip:IPR036388,18.0,2257.0,0.8116966899905711,0.029482086371241004,0.007975188303057155,,3.696726052216164,0.0,18.0,0.0,1.0,Helix/strand boundary signal,True,assigned_and_evaluated +15452,36535,22.566744,0.9736328,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8823242,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9975967957276368,0.8979472140762462,0.004430660168365086,0.9,202.6666862170088,13.0,13.0,89.79066265060241,1.1174852366600676e-25,Kinase αC helix K–E network,True,assigned_and_evaluated +15453,85649,29.956629,0.9819336,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9790039,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9495640496671988,0.5974597795368027,0.0101905183872397,0.7391304347826086,58.62898793106799,0.0,10.0,0.0,1.0,SDR cofactor-flanking patch activation,True,assigned_and_evaluated +15454,85649,17.467098,0.7426758,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.7426758,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8598925693822739,0.11144570163413459,0.0101905183872397,0.043478260869565216,10.93621515601051,0.0,16.0,0.0,1.0,Extracellular beta-solenoid strand peaks,True,assigned_and_evaluated +15455,27013,16.856289,0.8774414,side of membrane,go_cc,88058,Signal,0.65771484,76,go,GO:0098552,go_cc:go:GO:0098552,6.0,2257.0,0.899822301199467,0.07710270907609755,0.002658396101019052,,29.00346906412536,16.0,18.0,144.79902853673346,2.0662665485977494e-33,Fungal secretory targeting signals,True,assigned_and_evaluated +15456,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S8 subtilisin proteases propeptides,False,no_term_above_threshold +15457,50806,20.695295,0.9951172,"Homeobox, conserved site",interpro,43624,Homedomain-like superfamily,0.9760742,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,HTH DNA recognition helix,True,assigned_too_few_test_positives +15458,87276,30.282768,0.6142578,Cell membrane,keyword,25079,plasma membrane,0.61083984,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7403020023594555,0.44937631706080494,0.11120957022596367,0.5338645418326693,4.040806165761899,14.0,18.0,6.382038107471634,6.200736288989534e-10,Functional TM helix hotspots,True,assigned_and_evaluated +15459,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALDH Rossmann NAD-binding subdomain,False,no_term_above_threshold +15460,48241,17.338648,0.9838867,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.9838867,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,19.0,20.0,367.79188311688307,1.7236096947594326e-47,Nonheme iron beta-strand motifs,True,assigned_too_few_test_positives +15461,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Toprim fold recognition,False,no_term_above_threshold +15462,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase/nuclease catalytic cores,False,no_term_above_threshold +15463,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Class I aaRS DIXPV motif,False,no_term_above_threshold +15464,36914,19.198729,0.98046875,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9794922,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,19.0,19.0,736.0617283950618,1.2783113950738657e-53,Donor-proximal catalytic beta-strand,True,assigned_too_few_test_positives +15465,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane glycosyltransferase catalytic cores,False,no_term_above_threshold +15466,36091,23.068983,0.97753906,GNAT domain,interpro,85712,3.40.630.30,0.9399414,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,9.0,0.0,1.0,Proline-anchored PDZ N-cap motif,True,assigned_too_few_test_positives +15467,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal coiled-coil scaffolds,False,no_term_above_threshold +15468,82029,28.4326,0.9941406,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9848633,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,20.0,20.0,188.0788643533123,3.831366179140002e-45,Transmembrane glycine/aromatic clusters,True,assigned_too_few_test_positives +15469,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic beta-solenoids and inteins,False,no_term_above_threshold +15470,64016,42.67638,0.9477539,Thioredoxin-like superfamily,interpro,64016,Thioredoxin-like superfamily,0.9477539,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9979047619047619,0.6678571428571429,0.0031014621178555605,0.7142857142857143,215.33622448979594,8.0,10.0,177.31152416356878,1.6978891797250458e-17,Peroxiredoxin/GPx mid-block activation,True,assigned_and_evaluated +15471,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal domain motif hotspots,False,no_term_above_threshold +15472,-1,,,,,-1,,,0,,,,,,,,,,,,,,,MAT acyltransferase LHxxG-TP motif,False,no_term_above_threshold +15473,64594,20.004707,0.9511719,Zn(2)-C6 fungal-type DNA-binding domain superfamily,interpro,88150,Transcription regulation,0.6010742,74,ip,IPR036864,interpro:ip:IPR036864,8.0,2257.0,0.9934415295686972,0.28624218918336564,0.003544528134692069,,80.75607762335703,0.0,19.0,0.0,1.0,Disordered transcriptional activation domains,True,assigned_and_evaluated +15474,37894,16.140633,0.74365234,Short-chain dehydrogenase/reductase SDR,interpro,37894,Short-chain dehydrogenase/reductase SDR,0.74365234,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,20.0,0.0,1.0,HUH relaxase ssDNA-binding loops,True,assigned_too_few_test_positives +15475,38890,25.11986,0.97802734,HNH nuclease,interpro,38890,HNH nuclease,0.97802734,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,12.0,19.0,818.5949656750572,2.1671951925829672e-33,HNH active site flanks,True,assigned_too_few_test_positives +15476,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Single-pass cytosolic tails,False,no_term_above_threshold +15477,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal borosin N-methyltransferase motif,False,no_term_above_threshold +15478,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen Gly–X–Y motif detector,False,no_term_above_threshold +15479,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic acidic interaction patches,False,no_term_above_threshold +15480,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-rich disordered regulatory regions,False,no_term_above_threshold +15481,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-binding pockets and signatures,False,no_term_above_threshold +15482,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane ion-transport bundles,False,no_term_above_threshold +15483,45714,19.156496,0.8496094,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.8496094,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,HATPase_c N-box/ATP-lid helix,True,assigned_too_few_test_positives +15484,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DPP3 C-terminal amphipathic helix,False,no_term_above_threshold +15485,85672,23.70857,0.6459961,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6425781,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6847891340237131,0.23243933880067968,0.01595037660611431,0.25,14.572655213142614,16.0,16.0,40.01409395973155,6.696154575406941e-26,Kinase helical lid subdomain,True,assigned_and_evaluated +15486,36535,15.575571,0.96484375,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.8901367,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9413440142412104,0.852546240620011,0.004430660168365086,0.9,192.41968650793652,15.0,15.0,89.79066265060241,1.585928718533337e-29,Protein kinase-like catalytic domain,True,assigned_and_evaluated +15487,36914,20.594013,1.0,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.9902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,17.0,692.7639796659404,9.231629051889402e-45,Donor-adjacent glycosyltransferase catalytic loop,True,assigned_too_few_test_positives +15488,85364,18.171146,0.9526367,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9526367,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,19.0,19.0,301.1161616161616,1.046525603314554e-46,Venus flytrap ligand-binding cleft,True,assigned_too_few_test_positives +15489,45714,20.055393,0.8251953,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.8251953,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,17.0,0.0,1.0,Histidine kinase HATPase_c N-box,True,assigned_too_few_test_positives +15490,86130,20.7109,0.94970703,Zn(2)-C6 fungal-type DNA-binding domain,gene3d,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.94628906,71,gene3d,4.10.240.10,gene3d:gene3d:4.10.240.10,7.0,2257.0,0.9984444444444445,0.7890778533635676,0.0031014621178555605,0.8571428571428571,254.42124500593886,18.0,20.0,216.3665322580645,1.3281030920337989e-40,Fungal zinc-cluster activation domain,True,assigned_and_evaluated +15491,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DisA C-terminal helical motif,False,no_term_above_threshold +15492,27932,18.43326,0.64404297,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.61328125,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.502413424803845,0.036272599797189956,0.01949490474080638,0.022727272727272728,1.8606194941422214,0.0,14.0,0.0,1.0,Mixed-charge IDRs in nucleic-acid enzymes,True,assigned_and_evaluated +15493,45714,16.718653,0.96191406,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.96191406,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,16.0,0.0,1.0,Acidic-hydrophobic alpha-helix motif,True,assigned_too_few_test_positives +15494,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal outer membrane beta-barrel,False,no_term_above_threshold +15495,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site-adjacent phosphate-binding motifs,False,no_term_above_threshold +15496,50806,22.376564,0.8833008,"Homeobox, conserved site",interpro,37071,Homeodomain,0.8232422,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,15.0,0.0,1.0,Oxyanion-processing catalytic pockets,True,assigned_too_few_test_positives +15497,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged low-complexity IDRs,False,no_term_above_threshold +15498,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Edge-biased proline/charge motifs,False,no_term_above_threshold +15499,88058,91.33056,0.9296875,Signal,keyword,88058,Signal,0.9296875,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9289217194548717,0.7244732744678987,0.09127159946832078,0.883495145631068,7.93755427414586,18.0,19.0,6.825746541580537,1.3747497370901924e-14,Sec signal peptide N-h region,True,assigned_and_evaluated +15500,50763,16.319515,0.8095703,"Zinc finger, RING-type, conserved site",interpro,43624,Homedomain-like superfamily,0.7480469,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,20.0,0.0,1.0,HTH DNA-binding helices,True,assigned_too_few_test_positives +15501,45551,16.526613,0.82910156,SKP1/BTB/POZ domain superfamily,interpro,45551,SKP1/BTB/POZ domain superfamily,0.82910156,51,ip,IPR011333,interpro:ip:IPR011333,,,,,,,,0.0,20.0,0.0,1.0,Beta-strand edge loops,True,assigned_too_few_test_positives +15502,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic flexible edge segments,False,no_term_above_threshold +15503,88161,24.684517,0.6171875,Transmembrane helix,keyword,88161,Transmembrane helix,0.6171875,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7183909394223751,0.527197403281021,0.1847585290208241,0.44844124700239807,2.8534401419790516,10.0,16.0,3.3921825216203914,0.00021922286917669886,Hydrophobic transmembrane helices,True,assigned_and_evaluated +15504,36010,18.597738,0.9892578,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.95947266,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,6.0,19.0,160.92037786774628,2.920292889380285e-12,Alpha/beta-hydrolase catalytic domain,True,assigned_too_few_test_positives +15505,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Leucine-centric helical interface motifs,False,no_term_above_threshold +15506,30398,19.113447,0.7011719,ATP hydrolysis activity,go_mf,85672,P-loop containing nucleotide triphosphate hydrolases,0.6669922,141,go,GO:0016887,go_mf:go:GO:0016887,11.0,2257.0,0.6770420140856472,0.31219237120876464,0.004873726185201595,0.2727272727272727,64.05619834710744,7.0,7.0,72.00603864734299,2.1827814896242549e-13,ABC ATPase Walker B motif,True,assigned_and_evaluated +15507,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral glycoprotein ectodomain detector,False,no_term_above_threshold +15508,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long soluble alpha-helices,False,no_term_above_threshold +15509,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich low complexity IDRs,False,no_term_above_threshold +15510,38317,16.19539,0.9790039,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9790039,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9105396825396825,0.01839574269605669,0.0031014621178555605,,5.9313130378571355,0.0,15.0,0.0,1.0,Alpha-helical face/termini signal,True,assigned_and_evaluated +15511,-1,,,,,-1,,,0,,,,,,,,,,,,,,,YrdC-like carbamoyltransferase domain,False,no_term_above_threshold +15512,27936,18.278904,0.83691406,peptidyl-prolyl cis-trans isomerase activity,go_mf,27936,peptidyl-prolyl cis-trans isomerase activity,0.83691406,25,go,GO:0003755,go_mf:go:GO:0003755,,,,,,,,16.0,16.0,641.0860215053764,6.251782958608148e-45,FKBP immunophilin PPIase signature,True,assigned_too_few_test_positives +15513,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic/interface βαβ module,False,no_term_above_threshold +15514,36914,16.39792,0.9663086,Glycosyltransferase 2-like,interpro,36535,Protein kinase domain,0.90478516,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,12.0,0.0,1.0,ABC NBD Q-loop motif,True,assigned_too_few_test_positives +15515,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-strand accessory domains,False,no_term_above_threshold +15516,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S49 peptidase/trifunctional alpha,False,no_term_above_threshold +15517,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic ligand-binding regions,False,no_term_above_threshold +15518,37894,25.564938,0.9609375,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.7167969,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,10.0,709.7738095238095,6.270841561770282e-29,SDR YXXXK catalytic helix,True,assigned_too_few_test_positives +15519,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal low-complexity helices/linkers,False,no_term_above_threshold +15520,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flavin cofactor pocket lid loop,False,no_term_above_threshold +15521,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal pilin head detector,False,no_term_above_threshold +15522,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-flanked surface helix-loop,False,no_term_above_threshold +15523,37446,17.2226,0.6982422,F-box domain,interpro,37446,F-box domain,0.6982422,115,ip,IPR001810,interpro:ip:IPR001810,7.0,2257.0,0.7811428571428571,0.2707375674588789,0.0031014621178555605,0.14285714285714285,87.2935271078128,9.0,19.0,110.31846217105262,9.260498683435073e-17,Terminal regulatory IDRs,True,assigned_and_evaluated +15524,82597,16.415092,0.6694336,Tetratricopeptide repeat domain,gene3d,82597,Tetratricopeptide repeat domain,0.6694336,208,gene3d,1.25.40.10,gene3d:gene3d:1.25.40.10,13.0,2257.0,0.6422425613602085,0.024818280261985133,0.0057598582188746125,,4.308835273176957,0.0,17.0,0.0,1.0,C-terminal mixed-charge IDRs,True,assigned_and_evaluated +15525,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV N-cap helix motif,False,no_term_above_threshold +15526,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar low-complexity disordered regions,False,no_term_above_threshold +15527,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FNIII Cys-adjacent loop hotspot,False,no_term_above_threshold +15528,82716,17.0391,0.9716797,Laminin,gene3d,87413,Disulfide bond,0.60595703,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,0.0,19.0,0.0,1.0,Extracellular FnIII and collagens,True,assigned_too_few_test_positives +15529,81858,18.567337,0.9008789,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.67285156,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Extracytoplasmic juxtamembrane helix-exit motif,True,assigned_too_few_test_positives +15530,87856,15.750378,0.7392578,Nucleotidyltransferase,keyword,87856,Nucleotidyltransferase,0.7392578,166,keywords,Nucleotidyltransferase,keyword:keywords:Nucleotidyltransferase,28.0,2257.0,0.5929789143113503,0.03868330925705375,0.012405848471422242,,3.1181510354703685,9.0,17.0,44.835310828877006,2.1300693166585694e-13,Two-metal nucleotidyltransferase active site,True,assigned_and_evaluated +15531,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure boundary detector,False,no_term_above_threshold +15532,37430,17.534712,0.99853516,"Signal transduction response regulator, receiver domain",interpro,45288,CheY-like superfamily,0.9838867,30,ip,IPR001789,interpro:ip:IPR001789,,,,,,,,15.0,15.0,484.7235772357723,1.9394852943620235e-40,REC domain gly/acidic loop,True,assigned_too_few_test_positives +15533,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory low-complexity N-termini,False,no_term_above_threshold +15534,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical domain start marker,False,no_term_above_threshold +15535,36914,23.928034,0.9243164,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.9243164,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,9.0,16.0,414.03472222222223,3.11692588914336e-22,Glycosyltransferase catalytic core,True,assigned_too_few_test_positives +15536,45553,19.868969,0.9770508,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.93652344,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,8.0,16.0,342.64942528735634,4.779124980490084e-19,Nuclease catalytic domain recognition,True,assigned_too_few_test_positives +15537,87105,16.008595,0.7104492,4Fe-4S,keyword,30200,oxidoreductase activity,0.6098633,93,keywords,4Fe-4S,keyword:keywords:4Fe-4S,,,,,,,,10.0,12.0,123.9006650041563,2.888957414257283e-20,Ferredoxin-like 4Fe-4S domains,True,assigned_too_few_test_positives +15538,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-binding modules and clefts,False,no_term_above_threshold +15539,50338,18.761309,0.92333984,"GPCR, rhodopsin-like, 7TM",interpro,87276,Cell membrane,0.60791016,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,16.0,0.0,1.0,ABCA TM Asp-aromatic motif,True,assigned_too_few_test_positives +15540,82029,17.252087,0.86572266,MFS general substrate transporter like domains,gene3d,82029,MFS general substrate transporter like domains,0.86572266,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,18.0,0.0,1.0,Periplasmic SBP ligand cleft,True,assigned_too_few_test_positives +15541,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical assembly cores,False,no_term_above_threshold +15542,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Domain-start helix activation,False,no_term_above_threshold +15543,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Retained transmembrane signal anchors,False,no_term_above_threshold +15544,52236,21.354874,0.91064453,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.7675781,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,0.0,18.0,0.0,1.0,Central helical docking region,True,assigned_too_few_test_positives +15545,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered regions,False,no_term_above_threshold +15546,25167,16.166765,0.6464844,cell outer membrane,go_cc,25167,cell outer membrane,0.6464844,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.5348737936154416,0.015290392851868262,0.005316792202038104,,2.8758680555555554,13.0,19.0,93.34854871733108,1.1161617579429754e-23,TAA passengers and beta-solenoids,True,assigned_and_evaluated +15547,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flagellar switch/phosphatase recognition,False,no_term_above_threshold +15548,64155,17.3793,0.7368164,Ribonuclease H superfamily,interpro,46274,Ribonuclease H-like superfamily,0.7260742,57,ip,IPR036397,interpro:ip:IPR036397,,,,,,,,4.0,19.0,58.38041615667074,1.1792722434056024e-06,Nucleic acid nuclease interfaces,True,assigned_too_few_test_positives +15549,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-inserting alpha helices,False,no_term_above_threshold +15550,36535,19.04132,0.9765625,Protein kinase domain,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.8847656,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.986070315976858,0.19950299727006496,0.004430660168365086,,45.027826483853666,0.0,15.0,0.0,1.0,Two-component histidine kinase core,True,assigned_and_evaluated +15551,87326,36.615757,0.6933594,Coiled coil,keyword,87326,Coiled coil,0.6933594,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6761966706745719,0.29088283217550315,0.03943287549844927,0.29213483146067415,7.376657890113603,18.0,18.0,12.607528018608585,3.905291109887263e-20,Coiled-coil heptad repeats,True,assigned_and_evaluated +15552,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-to-coil capping hinges,False,no_term_above_threshold +15553,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helix boundary patches,False,no_term_above_threshold +15554,47529,16.112835,0.68115234,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.68115234,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.6123103525211959,0.041717891103137006,0.007089056269384138,,5.884830013736264,5.0,15.0,25.77648076091656,1.8531920646678365e-06,Extracellular Pro-Gly beta-turn motif,True,assigned_and_evaluated +15555,64620,17.259926,0.97021484,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.97021484,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,19.0,19.0,324.0271739130435,2.7035397615707734e-47,HisKA DHp N-cap helix,True,assigned_too_few_test_positives +15556,87970,19.887882,0.8310547,Protein phosphatase,keyword,87970,Protein phosphatase,0.8310547,27,keywords,Protein phosphatase,keyword:keywords:Protein phosphatase,,,,,,,,7.0,16.0,126.01056763285024,1.381726974770436e-13,Cytosolic sulfur-centered enzymes,True,assigned_too_few_test_positives +15557,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CBX/WRKY conserved motifs,False,no_term_above_threshold +15558,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"Short proteins, Pro/Gly-rich bias",False,no_term_above_threshold +15559,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase core helix,False,no_term_above_threshold +15560,45324,23.50917,0.99609375,Pectin lyase fold/virulence factor,interpro,87697,Knottin,0.7895508,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9990230905861457,0.5449999999999999,0.002215330084182543,1.0,246.01299999999998,4.0,14.0,156.2804718217562,2.094216363869575e-08,Extracellular carbohydrate-binding β-solenoids,True,assigned_and_evaluated +15561,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fe-S electron-transfer subunits,False,no_term_above_threshold +15562,25169,27.004826,0.91064453,pilus,go_cc,25169,pilus,0.91064453,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8988454706927176,0.8004430660168365,0.002215330084182543,0.8,361.32,18.0,20.0,496.84166666666664,6.404315153772672e-47,Chaperone-usher fimbrial pilins/adhesins,True,assigned_and_evaluated +15563,47717,19.687042,1.0,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.61865234,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,12.0,12.0,273.49082568807336,1.5561062230572482e-29,Helicase RecA1 Ia/Ib nucleic-acid-binding motif,True,assigned_too_few_test_positives +15564,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended single-pass glycoprotein regions,False,no_term_above_threshold +15565,82716,16.662188,0.97021484,Laminin,gene3d,87413,Disulfide bond,0.63134766,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,17.0,17.0,289.42233009708735,7.848216272787399e-42,Extracellular EGF-like ectodomains,True,assigned_too_few_test_positives +15566,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polar helical interaction surfaces,False,no_term_above_threshold +15567,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SHMT PLP-binding active-site motif,False,no_term_above_threshold +15568,59224,19.505554,0.9682617,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8413086,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9950793650793651,0.42722471763825143,0.0031014621178555605,0.5714285714285714,137.7494553870762,8.0,15.0,73.26697388632873,1.033761847795048e-13,Hydrophobic active-site pocket residues,True,assigned_and_evaluated +15569,87326,28.475563,0.6640625,Coiled coil,keyword,87326,Coiled coil,0.6640625,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7010474107550064,0.1554399181018235,0.03943287549844927,,3.941886462424895,11.0,17.0,8.157812247334968,1.2325868298949e-08,Coiled-coil–IDR regulatory boundary,True,assigned_and_evaluated +15570,52941,20.009823,0.7504883,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.7055664,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,18.0,18.0,260.353711790393,2.623430428618387e-43,Multipass transporter TM helices,True,assigned_too_few_test_positives +15571,63831,16.510792,0.8515625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.8515625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9342884643861987,0.0799185894288987,0.002658396101019052,,30.062709390170728,0.0,15.0,0.0,1.0,Conserved aromatic β‑strand hotspots,True,assigned_and_evaluated +15572,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short acidic polyanion-binding loops,False,no_term_above_threshold +15573,85649,19.835985,0.89990234,Vaccinia Virus protein VP39,gene3d,85649,Vaccinia Virus protein VP39,0.89990234,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8565353625783348,0.3305208723173584,0.0101905183872397,0.2608695652173913,32.43415690522947,17.0,17.0,110.61410018552876,7.110790058883305e-35,Hydrophobic SAM-pocket capping residues,True,assigned_and_evaluated +15574,38317,18.476227,0.86865234,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.81933594,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6307619047619046,0.03027655457397846,0.0031014621178555605,,9.762026239067055,0.0,19.0,0.0,1.0,TPR-like helix caps/linkers,True,assigned_and_evaluated +15575,50806,18.008945,0.80566406,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.80566406,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,10.0,0.0,1.0,Sigma-factor interdomain helix,True,assigned_too_few_test_positives +15576,82029,20.0222,0.92578125,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.60498047,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane helix kinks and termini,True,assigned_too_few_test_positives +15577,37468,19.534382,0.9682617,"Zinc finger, RING-type",interpro,29166,zinc ion binding,0.9213867,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,5.0,19.0,36.151467378122724,4.174136536270081e-07,Cys/His Zn-binding clusters,True,assigned_too_few_test_positives +15578,82029,20.478586,0.99365234,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7734375,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,9.0,16.0,105.79436119873817,8.127111603224353e-17,Transmembrane helix hydrophobic core,True,assigned_too_few_test_positives +15579,36914,25.2922,0.9980469,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.87402344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,11.0,15.0,539.7786008230453,6.897207878216635e-29,Glycosyltransferase catalytic loops,True,assigned_too_few_test_positives +15580,87276,34.5892,0.64208984,Cell membrane,keyword,88161,Transmembrane helix,0.6298828,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7142973470028162,0.45128757402078823,0.11120957022596367,0.4581673306772908,4.057992249262625,14.0,16.0,7.179792870905588,3.1869533622060737e-11,Juxtamembrane interhelical linkers,True,assigned_and_evaluated +15581,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral core midchain activation,False,no_term_above_threshold +15582,37341,24.21157,0.9902344,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9511719,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,17.0,17.0,145.4170731707317,7.415328584131598e-37,WD40 β-propeller activation,True,assigned_and_evaluated +15583,52941,26.870317,0.9746094,Major facilitator superfamily domain,interpro,64026,MFS transporter superfamily,0.9589844,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,5.0,19.0,68.51413468168236,1.7896081494084555e-08,12-TM MFS intracellular gate detector,True,assigned_too_few_test_positives +15584,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface loops near active sites,False,no_term_above_threshold +15585,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ThDP-binding PYR/PP fold signature,False,no_term_above_threshold +15586,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Global DyP fold activation,False,no_term_above_threshold +15587,37341,18.723858,0.9892578,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.95458984,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9995598737751203,0.9470149285257017,0.011962782454585734,1.0,79.16343309935218,0.0,19.0,0.0,1.0,Hydrophobic beta-strand core anchors,True,assigned_and_evaluated +15588,87326,21.353447,0.61816406,Coiled coil,keyword,87326,Coiled coil,0.61816406,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.601533023757204,0.1131153985383311,0.03943287549844927,0.056179775280898875,2.868555668550711,14.0,17.0,10.382670132971775,4.623589871267067e-13,Extended coiled-coil stalks,True,assigned_and_evaluated +15589,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-chain hydrophobic core,False,no_term_above_threshold +15590,36091,17.567709,0.9790039,GNAT domain,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9243164,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,REC output-coupling helices,True,assigned_too_few_test_positives +15591,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal amphipathic helical stalks,False,no_term_above_threshold +15592,88161,25.236431,0.62060547,Transmembrane helix,keyword,88159,Transmembrane,0.6196289,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6027727817745803,0.2617952035570369,0.1847585290208241,0.02877697841726619,1.416958691674418,17.0,17.0,5.4274920345926265,7.1365032769983e-13,Membrane-embedded alpha-helical residues,True,assigned_and_evaluated +15593,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic N-terminal linker,False,no_term_above_threshold +15594,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal nucleic acid-binding modules,False,no_term_above_threshold +15595,50806,21.862135,0.76416016,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.76416016,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,19.0,0.0,1.0,M16/MPP metallopeptidase fold detector,True,assigned_too_few_test_positives +15596,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble α-helical interaction scaffolds,False,no_term_above_threshold +15597,49045,25.511444,0.9995117,Kelch-type beta propeller,interpro,49045,Kelch-type beta propeller,0.9995117,39,ip,IPR015915,interpro:ip:IPR015915,,,,,,,,19.0,19.0,542.0090909090909,4.3313349653425253e-51,Kelch beta-propeller selectivity,True,assigned_too_few_test_positives +15598,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic and Gly/Pro phosphate-binding loops,False,no_term_above_threshold +15599,66234,19.683136,0.9013672,Papain-like cysteine peptidase superfamily,interpro,66234,Papain-like cysteine peptidase superfamily,0.9013672,64,ip,IPR038765,interpro:ip:IPR038765,,,,,,,,10.0,10.0,236.59126984126982,4.479955401940688e-24,Papain-like cysteine protease propeptides,True,assigned_too_few_test_positives +15600,88161,37.05153,0.69433594,Transmembrane helix,keyword,88161,Transmembrane helix,0.69433594,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6922394692941299,0.36962553617046234,0.1847585290208241,0.3261390887290168,2.000587134620464,14.0,14.0,5.4274920345926265,1.0920821671226735e-10,N-terminal ERPFS/TD cytosolic motif,True,assigned_and_evaluated +15601,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidoglycan glycan strand enzymes,False,no_term_above_threshold +15602,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helical active-site cap,False,no_term_above_threshold +15603,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan binding groove surfaces,False,no_term_above_threshold +15604,39971,20.472815,0.8623047,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.83691406,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,16.0,0.0,1.0,EEP/DNase-like Mg2+ phosphoesterases,True,assigned_too_few_test_positives +15605,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretion-associated helical scaffolds,False,no_term_above_threshold +15606,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Terminal alpha-helix detector,False,no_term_above_threshold +15607,52236,27.041561,0.9868164,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.96777344,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,16.0,17.0,210.16435338180213,1.624802082425761e-36,Conserved TPR/SEL1 A-helix positions,True,assigned_too_few_test_positives +15608,85364,25.85882,0.9472656,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9472656,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,5.0,18.0,83.64337822671156,6.470799817269711e-09,Venus flytrap PBP domains,True,assigned_too_few_test_positives +15609,52940,18.280064,0.9423828,"AMP-binding, conserved site",interpro,36668,AMP-dependent synthetase/ligase domain,0.88671875,28,ip,IPR020845,interpro:ip:IPR020845,,,,,,,,0.0,19.0,0.0,1.0,CARF/SM N-terminal elements,True,assigned_too_few_test_positives +15610,87238,15.695133,0.67626953,CF(0),keyword,87238,CF(0),0.67626953,39,keywords,CF(0),keyword:keywords:CF(0),,,,,,,,0.0,16.0,0.0,1.0,Positive-inside TM boundary motif,True,assigned_too_few_test_positives +15611,36886,19.941065,0.94873047,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.94873047,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9348599377501111,0.8476652882390587,0.003544528134692069,0.875,239.14756944444446,18.0,19.0,221.5021671826625,2.4241042625813076e-41,Zn2C6 coiled-coil dimerization helix,True,assigned_and_evaluated +15612,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Globular hydrophobic interface patches,False,no_term_above_threshold +15613,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfatase catalytic loop motifs,False,no_term_above_threshold +15614,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-strand glycine motif,False,no_term_above_threshold +15615,36010,16.886248,0.87841797,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.875,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,14.0,0.0,1.0,Alpha/beta-hydrolase upstream helix activation,True,assigned_too_few_test_positives +15616,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helix anchor,False,no_term_above_threshold +15617,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended coiled-coils and collagens,False,no_term_above_threshold +15618,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short amphipathic interface patch,False,no_term_above_threshold +15619,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular receptor-binding heads,False,no_term_above_threshold +15620,84152,16.024582,0.8588867,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8588867,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,0.0,15.0,0.0,1.0,Metalloenzyme coordination microenvironments,True,assigned_too_few_test_positives +15621,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic metal-binding amphipathic helices,False,no_term_above_threshold +15622,87326,27.067703,0.64453125,Coiled coil,keyword,87326,Coiled coil,0.64453125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.5899653799908785,0.059568014471304886,0.03943287549844927,,1.5106180748509566,8.0,16.0,6.303764009304293,2.087797279889246e-05,Short amphipathic oligomerization helices,True,assigned_and_evaluated +15623,81685,21.772984,0.9682617,Transferase(Phosphotransferase) domain 1,gene3d,64146,Winged helix-like DNA-binding domain superfamily,0.8745117,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9547884187082405,0.9171097326835032,0.005316792202038104,0.9166666666666666,172.49305555555554,19.0,19.0,85.66235632183908,8.858414841848649e-37,Conserved kinase hydrophobic spine,True,assigned_and_evaluated +15624,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gram-negative OM beta-barrel signature,False,no_term_above_threshold +15625,87108,28.131275,0.9560547,ANK repeat,keyword,88009,Repeat,0.69091797,124,keywords,ANK repeat,keyword:keywords:ANK repeat,9.0,2257.0,0.9948596283115857,0.5147223307113951,0.003987594151528578,0.4444444444444444,129.08092226840208,12.0,18.0,112.91856060606061,7.527230792906628e-23,Tandem repeat scaffold detector,True,assigned_and_evaluated +15626,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular β-strand/loop surfaces,False,no_term_above_threshold +15627,-1,,,,,-1,,,0,,,,,,,,,,,,,,,2OG Fe(II) oxygenase DSBH core,False,no_term_above_threshold +15628,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Internal structured scaffolding regions,False,no_term_above_threshold +15629,82716,17.356527,0.9428711,Laminin,gene3d,87413,Disulfide bond,0.7529297,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,0.0,13.0,0.0,1.0,TSR and related cysteine-rich domains,True,assigned_too_few_test_positives +15630,49116,18.623402,0.78027344,Armadillo-type fold,interpro,49116,Armadillo-type fold,0.78027344,183,ip,IPR016024,interpro:ip:IPR016024,5.0,2257.0,0.894271758436945,0.3407371836638954,0.002215330084182543,0.2,153.8087647058824,12.0,18.0,58.02530413625304,2.143081455413402e-19,Extended acidic regulatory tracts,True,assigned_and_evaluated +15631,82029,18.360971,0.8857422,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.7167969,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,16.0,0.0,1.0,Transmembrane helix entry/exit caps,True,assigned_too_few_test_positives +15632,81799,18.496855,0.9638672,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8149414,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,11.0,17.0,374.54654483152484,9.324180012088984e-27,AAA+ SRH coupling helix,True,assigned_too_few_test_positives +15633,48255,17.2864,0.74609375,Rossmann-like alpha/beta/alpha sandwich fold,interpro,48255,Rossmann-like alpha/beta/alpha sandwich fold,0.74609375,43,ip,IPR014729,interpro:ip:IPR014729,,,,,,,,2.0,15.0,45.42552380952381,0.0015453265377314946,Metallo/NTP β→α active-site modules,True,assigned_too_few_test_positives +15634,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal accessory segment,False,no_term_above_threshold +15635,38317,16.04858,0.7138672,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7138672,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6335555555555555,0.03051070620564562,0.0031014621178555605,,9.837523415163167,0.0,17.0,0.0,1.0,Transmembrane helix N-cap,True,assigned_and_evaluated +15636,81799,19.427565,0.9604492,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7314453,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,2.0,20.0,57.884466019417474,0.0009757263107686749,P-loop NTPase helical lid,True,assigned_too_few_test_positives +15637,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-VWFA VIT domain marker,False,no_term_above_threshold +15638,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity tandem repeats,False,no_term_above_threshold +15639,29104,21.096199,0.828125,NADH dehydrogenase (ubiquinone) activity,go_mf,29104,NADH dehydrogenase (ubiquinone) activity,0.828125,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,10.0,15.0,285.95203836930455,2.8922492609585223e-23,Transmembrane helix-loop junctions,True,assigned_too_few_test_positives +15640,46277,17.11994,0.7319336,"Nucleic acid-binding, OB-fold",interpro,46277,"Nucleic acid-binding, OB-fold",0.7319336,87,ip,IPR012340,interpro:ip:IPR012340,11.0,2257.0,0.8984659596859064,0.3119439345598923,0.004873726185201595,0.36363636363636365,64.00522366378881,0.0,17.0,0.0,1.0,M23/M35 HxGxD zinc motif,True,assigned_and_evaluated +15641,59224,27.556044,0.99316406,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.99316406,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9999365079365079,0.982142857142857,0.0031014621178555605,1.0,316.67091836734687,18.0,18.0,137.37557603686636,1.6332112516921354e-38,ABHD core beta-strand marker,True,assigned_and_evaluated +15642,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalysis-adjacent binding surfaces,False,no_term_above_threshold +15643,50806,15.677157,0.80810547,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.80810547,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,16.0,0.0,1.0,Embedded β-sheet subdomains,True,assigned_too_few_test_positives +15644,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix-loop-helix hairpins,False,no_term_above_threshold +15645,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Signal-coupling beta-hairpin turns,False,no_term_above_threshold +15646,48241,21.429152,0.98535156,RmlC-like jelly roll fold,interpro,48241,RmlC-like jelly roll fold,0.98535156,38,ip,IPR014710,interpro:ip:IPR014710,,,,,,,,19.0,20.0,367.79188311688307,1.7236096947594326e-47,Cupin/DSBH ligand-binding pocket,True,assigned_too_few_test_positives +15647,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-coordinating catalytic loops,False,no_term_above_threshold +15648,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal subdomain and tail,False,no_term_above_threshold +15649,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core segments,False,no_term_above_threshold +15650,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical interaction surface,False,no_term_above_threshold +15651,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active site support helices,False,no_term_above_threshold +15652,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-motif and phage-coat detector,False,no_term_above_threshold +15653,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted beta-ectodomain glycoprotein signal,False,no_term_above_threshold +15654,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulatory low-complexity IDRs,False,no_term_above_threshold +15655,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane low-complexity IDRs,False,no_term_above_threshold +15656,36091,27.11267,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.99121094,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,18.0,18.0,377.3481012658228,4.134258327034305e-46,GNAT C-terminal cap,True,assigned_too_few_test_positives +15657,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary-structure core residues,False,no_term_above_threshold +15658,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Gly-rich low-complexity disorder,False,no_term_above_threshold +15659,72011,17.787008,0.9711914,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.93310547,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Whole-chain activation with central peaks,True,assigned_too_few_test_positives +15660,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-rich terminal catalytic lobe,False,no_term_above_threshold +15661,37020,18.217651,0.98876953,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.96972656,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,1.0,19.0,42.985580389329485,0.0386076117710189,Glycosyltransferase active-site loops,True,assigned_too_few_test_positives +15662,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracellular and surface-associated proteins,False,no_term_above_threshold +15663,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Flanking glycine-rich helical hairpins,False,no_term_above_threshold +15664,63831,18.39958,0.9213867,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9213867,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.925699689027099,0.019614119292011047,0.002658396101019052,,7.378177873678155,0.0,16.0,0.0,1.0,Hydrophobic helix core residues,True,assigned_and_evaluated +15665,52236,20.670237,0.9916992,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98046875,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,15.0,18.0,186.08302122347067,1.3855153806489415e-32,TPR-adjacent capping/linker segments,True,assigned_too_few_test_positives +15666,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isoprenoid acidic motif helices,False,no_term_above_threshold +15667,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TOPRIM-like acidic beta–alpha module,False,no_term_above_threshold +15668,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protease catalytic core loop,False,no_term_above_threshold +15669,28962,18.753208,0.67529297,oxygen carrier activity,go_mf,28962,oxygen carrier activity,0.67529297,51,go,GO:0005344,go_mf:go:GO:0005344,,,,,,,,14.0,16.0,628.5346385542168,2.673694221541573e-38,Globin heme-binding fold detector,True,assigned_too_few_test_positives +15670,87882,24.325788,0.78515625,Palmitate,keyword,88058,Signal,0.69433594,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.9714571301643714,0.11700482766866946,0.002658396101019052,,44.01331600803116,0.0,19.0,0.0,1.0,Gram-positive Sec/sortase signals,True,assigned_and_evaluated +15671,47717,17.35356,0.99560547,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6875,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,14.0,14.0,273.49082568807336,2.439567240558689e-34,Helicase Q-motif/A-loop,True,assigned_too_few_test_positives +15672,64620,18.019728,0.87646484,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.87646484,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,19.0,20.0,307.8258152173913,4.134258327034305e-46,Bergerat ATP-lid beta-hairpin,True,assigned_too_few_test_positives +15673,85664,16.496084,0.9770508,Glycogen Phosphorylase B;,gene3d,59224,Alpha/Beta hydrolase fold,0.87597656,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,17.0,331.22777777777776,8.574008912125439e-43,Glycosyltransferase C-terminal helix packing,True,assigned_too_few_test_positives +15674,36091,17.329418,0.9536133,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9223633,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,18.0,0.0,1.0,Glycine-rich terminal/loop motifs,True,assigned_too_few_test_positives +15675,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal docking interfaces,False,no_term_above_threshold +15676,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine phosphotransfer domain detector,False,no_term_above_threshold +15677,45324,16.314554,0.99658203,Pectin lyase fold/virulence factor,interpro,61392,Leucine-rich repeat domain superfamily,0.99560547,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9984902309058614,0.4442857142857143,0.002215330084182543,1.0,200.55057142857143,4.0,13.0,168.30204657727595,1.5042217291200914e-08,Extracellular beta-strand solenoid repeats,True,assigned_and_evaluated +15678,82029,26.610888,0.9995117,MFS general substrate transporter like domains,gene3d,88162,Transport,0.6225586,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Transmembrane glycine hinge motifs,True,assigned_too_few_test_positives +15679,59224,23.179876,0.95996094,Alpha/Beta hydrolase fold,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7919922,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9994285714285713,0.8214285714285714,0.0031014621178555605,1.0,264.8520408163265,19.0,19.0,137.37557603686636,1.4828928465544412e-40,ABH pre-nucleophile beta-strand,True,assigned_and_evaluated +15680,38654,24.075104,0.9057617,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.89941406,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,14.0,0.0,1.0,Extracellular disulfide-stabilized loops,True,assigned_too_few_test_positives +15681,88161,47.4203,0.64941406,Transmembrane helix,keyword,88161,Transmembrane helix,0.64941406,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.6605685017203629,0.3847607361376688,0.1847585290208241,0.38848920863309355,2.0825059507499244,18.0,20.0,4.884742831133364,1.6557020938606967e-11,N-terminal signal-anchor helix,True,assigned_and_evaluated +15682,36104,24.36028,0.96191406,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.96191406,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,8.0,0.0,1.0,Pore-lining transmembrane helices,True,assigned_too_few_test_positives +15683,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pyruvate kinase helix-packing hydrophobes,False,no_term_above_threshold +15684,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular Gly/Pro-rich flexible linkers,False,no_term_above_threshold +15685,87276,29.322783,0.6044922,Cell membrane,keyword,87276,Cell membrane,0.6044922,2257,keywords,Cell membrane,keyword:keywords:Cell membrane,251.0,2257.0,0.7058704364992672,0.44848319497496647,0.11120957022596367,0.44223107569721115,4.032775183499997,10.0,12.0,6.837897972291036,7.44372002892236e-08,Transmembrane loop-helix junctions,True,assigned_and_evaluated +15686,37468,16.702555,0.96191406,"Zinc finger, RING-type",interpro,87413,Disulfide bond,0.8232422,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,2.0,18.0,15.263952892985149,0.012811192401536386,Histidine-peaked Cys/His clusters,True,assigned_too_few_test_positives +15687,-1,,,,,-1,,,0,,,,,,,,,,,,,,,aaRS editing and accessory lobes,False,no_term_above_threshold +15688,82029,16.484564,0.8955078,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.65625,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,19.0,0.0,1.0,Transmembrane helix entry sites,True,assigned_too_few_test_positives +15689,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered C-terminal regulatory tails,False,no_term_above_threshold +15690,47717,16.564585,0.78564453,"Helicase superfamily 1/2, ATP-binding domain",interpro,47717,"Helicase superfamily 1/2, ATP-binding domain",0.78564453,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,7.0,7.0,273.49082568807336,1.945115556631285e-17,DEAD-box helicase ATP-binding lobe,True,assigned_too_few_test_positives +15691,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer membrane β-barrel detector,False,no_term_above_threshold +15692,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coil to beta-strand junctions,False,no_term_above_threshold +15693,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic low-complexity disordered regions,False,no_term_above_threshold +15694,85791,26.952578,0.88183594,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,gene3d,85791,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.88183594,36,gene3d,3.60.15.10,gene3d:gene3d:3.60.15.10,,,,,,,,0.0,14.0,0.0,1.0,Cysteine-nucleophile active-site neighborhood,True,assigned_too_few_test_positives +15695,87317,15.6628895,0.6513672,Cleavage on pair of basic residues,keyword,87317,Cleavage on pair of basic residues,0.6513672,189,keywords,Cleavage on pair of basic residues,keyword:keywords:Cleavage on pair of basic residues,16.0,2257.0,0.6680890227576974,0.02807393985894998,0.007089056269384138,,3.9601801413531317,0.0,14.0,0.0,1.0,Extracellular mucin-like low-complexity regions,True,assigned_and_evaluated +15696,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Luminal β-rich glycoprotein ectodomains,False,no_term_above_threshold +15697,36104,28.732525,1.0,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,1.0,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,9.0,0.0,1.0,Amphipathic coiled-coil helices,True,assigned_too_few_test_positives +15698,85664,19.34061,0.8935547,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.8935547,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,14.0,0.0,1.0,ABC NBD pre-Walker A-loop,True,assigned_too_few_test_positives +15699,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cell wall glycanase catalytic groove,False,no_term_above_threshold +15700,49236,20.801931,0.9951172,C-type lectin fold,interpro,49236,C-type lectin fold,0.9951172,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9980461811722913,0.4042424242424242,0.002215330084182543,0.4,182.47503030303028,0.0,14.0,0.0,1.0,Disulfide-clamped glycan-binding beta-strand,True,assigned_and_evaluated +15701,27733,18.306044,0.8388672,RNA polymerase II cis-regulatory region sequence-specific DNA binding,go_mf,88150,Transcription regulation,0.63134766,185,go,GO:0000978,go_mf:go:GO:0000978,23.0,2257.0,0.8651862519948621,0.22313451102620876,0.0101905183872397,0.13043478260869565,21.89628658200666,1.0,14.0,3.836615186615186,0.36408391011242147,Disordered low-complexity activation regions,True,assigned_and_evaluated +15702,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich surface beta loops,False,no_term_above_threshold +15703,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PfkB/ribokinase β–α–β core,False,no_term_above_threshold +15704,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Anion-binding mixed-charge IDRs,False,no_term_above_threshold +15705,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic luminal PA ectodomains,False,no_term_above_threshold +15706,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta1-alpha1 cofactor-binding loop,False,no_term_above_threshold +15707,87326,22.818867,0.64990234,Coiled coil,keyword,87326,Coiled coil,0.64990234,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6834316306646213,0.143457423244925,0.03943287549844927,0.011235955056179775,3.638015778244896,10.0,15.0,8.40501867907239,4.028472162542888e-08,Coiled-coil interaction helices,True,assigned_and_evaluated +15708,49061,18.38089,0.9243164,WD40/YVTN repeat-like-containing domain superfamily,interpro,87413,Disulfide bond,0.640625,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.996210664615779,0.7982472148917299,0.012405848471422242,0.9285714285714286,64.34442728609409,0.0,17.0,0.0,1.0,Response regulator N-termini,True,assigned_and_evaluated +15709,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic assembly helices,False,no_term_above_threshold +15710,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic catalytic pocket flanks,False,no_term_above_threshold +15711,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting segments,False,no_term_above_threshold +15712,36272,16.663473,0.97998047,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,45290,Protein kinase-like domain superfamily,0.76220703,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,2.0,16.0,173.3168604651163,0.00011108132636472885,Helical kinase catalytic core,True,assigned_too_few_test_positives +15713,83302,18.265606,0.8964844,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.89453125,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.9583501983323889,0.061665053024195476,0.004873726185201595,,12.652547697782655,3.0,18.0,34.26494252873563,0.0001607185300155748,Exposed beta-hairpin interface patches,True,assigned_and_evaluated +15714,37007,20.073523,0.97802734,Metallo-beta-lactamase,interpro,64596,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like,0.9580078,26,ip,IPR001279,interpro:ip:IPR001279,,,,,,,,7.0,13.0,445.88354700854694,1.1669201201862491e-17,Regulatory C-terminal tails,True,assigned_too_few_test_positives +15715,36449,16.526499,0.8691406,EamA domain,interpro,36449,EamA domain,0.8691406,35,ip,IPR000620,interpro:ip:IPR000620,,,,,,,,0.0,16.0,0.0,1.0,N-terminal beta-strand block,True,assigned_too_few_test_positives +15716,36115,15.828016,0.72802734,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.7109375,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,16.0,0.0,1.0,Sensory domain capping loops,True,assigned_too_few_test_positives +15717,85672,18.13859,0.73876953,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.73779297,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.7856446045324929,0.04679168025891434,0.01595037660611431,,2.933578398454713,3.0,16.0,7.5026426174496645,0.011722483303356672,Helix-capping acidic motifs,True,assigned_and_evaluated +15718,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DXR C-terminal motif peak,False,no_term_above_threshold +15719,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich phosphate-binding lid,False,no_term_above_threshold +15720,36668,20.859917,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.984375,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,16.0,16.0,532.3303571428571,1.242588780751951e-43,ANL AMP-binding enzymes,True,assigned_too_few_test_positives +15721,27735,16.050451,0.78271484,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,88150,Transcription regulation,0.6411133,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.8404044409199047,0.07132755018981318,0.011519716437749225,,6.191780029938783,0.0,20.0,0.0,1.0,Acidic serine-rich IDRs,True,assigned_and_evaluated +15722,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carboxylate-rich catalytic patches,False,no_term_above_threshold +15723,46274,21.047026,0.95996094,Ribonuclease H-like superfamily,interpro,46274,Ribonuclease H-like superfamily,0.95996094,72,ip,IPR012337,interpro:ip:IPR012337,38.0,2257.0,0.9967268328550082,0.6901881252937608,0.016836508639787327,1.0,40.9935420733689,13.0,14.0,225.05023228803714,3.876331592419311e-30,DDE/DEDH RNase H–fold nucleases,True,assigned_and_evaluated +15724,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphoribosyltransferase PRPP-binding core,False,no_term_above_threshold +15725,48767,17.019032,0.9892578,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.9892578,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,0.0,13.0,0.0,1.0,Glycine-biased beta-strand N-cap,True,assigned_too_few_test_positives +15726,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Chain-wide M17 N-terminal motif activation,False,no_term_above_threshold +15727,49236,16.364975,0.8569336,C-type lectin fold,interpro,49236,C-type lectin fold,0.8569336,27,ip,IPR016187,interpro:ip:IPR016187,5.0,2257.0,0.9928952042628774,0.14881736620867056,0.002215330084182543,,67.1761591065939,0.0,18.0,0.0,1.0,Helix-loop-beta sensory motif,True,assigned_and_evaluated +15728,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oxyanion-stabilizing Gly/Ser-rich loops,False,no_term_above_threshold +15729,37341,28.987043,0.99853516,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.99365234,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,0.9999999999999998,0.011962782454585734,1.0,83.59259259259257,17.0,18.0,137.33834688346883,1.1881488769566902e-35,WD40 hydrophobic ladder sites,True,assigned_and_evaluated +15730,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM helix packing faces,False,no_term_above_threshold +15731,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Peptidase M13 neprilysin detector,False,no_term_above_threshold +15732,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction surfaces,False,no_term_above_threshold +15733,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Eukaryotic signal peptides and IDRs,False,no_term_above_threshold +15734,85675,20.579256,0.95214844,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.94091797,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,17.0,19.0,489.4046354418155,2.380120168403542e-44,VWA/I A-domain MIDAS surface,True,assigned_too_few_test_positives +15735,81540,15.688642,0.99902344,"Tetracycline Repressor, domain 2",gene3d,81540,"Tetracycline Repressor, domain 2",0.99902344,30,gene3d,1.10.357.10,gene3d:gene3d:1.10.357.10,,,,,,,,20.0,20.0,828.0694444444445,2.4307463492151184e-57,Amphipathic helical bundle pockets,True,assigned_too_few_test_positives +15736,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil linker helices,False,no_term_above_threshold +15737,61392,23.205723,1.0,Leucine-rich repeat domain superfamily,interpro,88009,Repeat,0.6279297,80,ip,IPR032675,interpro:ip:IPR032675,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,11.0,11.0,167.4747191011236,8.831826373930315e-25,LRR LP turn motif,True,assigned_and_evaluated +15738,58239,21.044836,0.6118164,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6118164,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.5822958953540821,0.12226540932483555,0.017722640673460344,0.125,6.898825721153846,13.0,20.0,23.303457606734817,9.053997763361595e-16,P-loop NTPase superfamily,True,assigned_and_evaluated +15739,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr-rich mucin-like repeats,False,no_term_above_threshold +15740,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal glycosylation catalytic ectodomains,False,no_term_above_threshold +15741,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended extracellular adhesion regions,False,no_term_above_threshold +15742,37341,19.93992,0.9868164,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9785156,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9929828932071084,0.49605767923058286,0.011962782454585734,0.5925925925925926,41.46674748234909,2.0,18.0,16.157452574525742,0.011509637433282762,Beta-propeller blade beta-strand detector,True,assigned_and_evaluated +15743,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Viral beta-strand ligand-binding detector,False,no_term_above_threshold +15744,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding low-complexity patches,False,no_term_above_threshold +15745,39958,15.681297,0.8491211,Basic-leucine zipper domain,interpro,8200,proteolysis,0.6152344,26,ip,IPR004827,interpro:ip:IPR004827,6.0,2257.0,0.9857840959573523,0.09411300445918856,0.002658396101019052,,35.40217517739809,0.0,12.0,0.0,1.0,Protease active-site helices,True,assigned_and_evaluated +15746,36951,15.616786,0.9614258,SET domain,interpro,36951,SET domain,0.9614258,28,ip,IPR001214,interpro:ip:IPR001214,,,,,,,,17.0,17.0,469.4566929133858,2.9906151964577645e-45,SET-domain N-terminal regulatory flanks,True,assigned_too_few_test_positives +15747,81858,17.156015,0.8222656,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.62353516,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Cytosolic TM boundary anchor,True,assigned_too_few_test_positives +15748,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular beta-loop/edge strands,False,no_term_above_threshold +15749,31094,16.110462,0.9057617,phosphopantetheine binding,go_mf,87913,Phosphopantetheine,0.77246094,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9442812639074322,0.22859868233034758,0.004430660168365086,,51.594722601959454,0.0,15.0,0.0,1.0,Cysteine-centered catalytic modules,True,assigned_and_evaluated +15750,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Double-stranded RNA-binding signature,False,no_term_above_threshold +15751,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal substrate-binding tail,False,no_term_above_threshold +15752,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Papain family propeptides,False,no_term_above_threshold +15753,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary active transporter TM bundles,False,no_term_above_threshold +15754,58239,19.660206,0.6586914,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6586914,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6129679747406405,0.14257667007191285,0.017722640673460344,0.175,8.044888608807684,9.0,9.0,35.851473241130485,2.309016775409654e-14,AAA+ inter-subunit signaling helix,True,assigned_and_evaluated +15755,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Unknown generic feature,False,no_term_above_threshold +15756,12207,15.570429,0.74365234,transposition,go_bp,10369,DNA integration,0.7089844,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,2.0,15.0,172.8144927536232,0.00011138188427076841,Retroelement integrase region signature,True,assigned_too_few_test_positives +15757,45553,19.114796,0.81103516,Restriction endonuclease type II-like,interpro,4066,type II site-specific deoxyribonuclease,0.78759766,30,ip,IPR011335,interpro:ip:IPR011335,,,,,,,,2.0,15.0,91.37318007662836,0.0003934441029121459,Metal-dependent nuclease cores,True,assigned_too_few_test_positives +15758,85675,18.655523,0.90283203,"von Willebrand factor, type A domain",gene3d,64214,von Willebrand factor A-like domain superfamily,0.8881836,33,gene3d,3.40.50.410,gene3d:gene3d:3.40.50.410,,,,,,,,15.0,18.0,455.81804281345563,1.779622673141242e-38,VWA MIDAS acidic loop signature,True,assigned_too_few_test_positives +15759,83419,22.402418,0.9824219,2.60.120.200,gene3d,47128,Concanavalin A-like lectin/glucanase domain superfamily,0.97216797,51,gene3d,2.60.120.200,gene3d:gene3d:2.60.120.200,,,,,,,,17.0,19.0,325.2750320924262,2.2070817398232315e-41,Aromatic beta-strand binding clefts,True,assigned_too_few_test_positives +15760,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane helices,False,no_term_above_threshold +15761,82029,33.514626,0.9946289,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9819336,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,16.0,19.0,158.38220156068402,1.2522467477825838e-33,MFS C-terminal TM helix,True,assigned_too_few_test_positives +15762,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved glycine-rich micro-motifs,False,no_term_above_threshold +15763,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Trp-centered glycan-binding platforms,False,no_term_above_threshold +15764,42054,17.25964,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,14.0,677.5113636363636,6.4988362365136876e-40,rSAM AdoMet-binding pocket,True,assigned_too_few_test_positives +15765,50869,17.322388,1.0,"DNA binding HTH domain, AraC-type",interpro,27918,DNA-binding transcription factor activity,0.6069336,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,19.0,19.0,917.2461538461538,1.6344645258281847e-55,Post-HTH basic tail/hairpin,True,assigned_too_few_test_positives +15766,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich helix-capping loop,False,no_term_above_threshold +15767,81858,19.340813,0.9609375,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.67285156,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,19.0,0.0,1.0,Hydrophobic transmembrane and interfacial helices,True,assigned_too_few_test_positives +15768,85682,16.437931,0.8334961,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8222656,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.967078853046595,0.3620462322065626,0.011076650420912717,0.28,32.685533843608475,7.0,17.0,42.109474321461,3.085103627491876e-10,Cofactor-proximal loop activation,True,assigned_and_evaluated +15769,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-sequence metal-proximal loop,False,no_term_above_threshold +15770,72011,19.210173,0.9794922,"AMP-binding enzyme, C-terminal domain superfamily",interpro,72011,"AMP-binding enzyme, C-terminal domain superfamily",0.9794922,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Conserved nucleotidyl cyclase helix,True,assigned_too_few_test_positives +15771,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended helical interaction modules,False,no_term_above_threshold +15772,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AKR active-site loop,False,no_term_above_threshold +15773,85682,15.742717,0.8051758,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8051758,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.940152329749104,0.21168048738592254,0.011076650420912717,0.04,19.110514401201087,1.0,14.0,7.3047047292330305,0.2058664264707413,Glycine-rich oxyanion-binding loops,True,assigned_and_evaluated +15774,38317,15.840996,0.9042969,Pentatricopeptide repeat,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.84521484,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.788920634920635,0.009492044079948083,0.0031014621178555605,,3.0605062126346887,0.0,18.0,0.0,1.0,Anion-binding catalytic loop detector,True,assigned_and_evaluated +15775,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fungal SP/TP-rich regulatory IDRs,False,no_term_above_threshold +15776,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Collagen Gly-X-Y triple helix,False,no_term_above_threshold +15777,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNA-binding low-complexity IDRs,False,no_term_above_threshold +15778,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered low-complexity N-termini,False,no_term_above_threshold +15779,52236,25.460133,0.99072266,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.8227539,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,TPR/SEL1 hydrophobic packing residues,True,assigned_too_few_test_positives +15780,85762,22.962107,0.80908203,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.7998047,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,18.0,18.0,205.58965517241379,1.4365296813653038e-41,N-terminal FAD-proximal activation,True,assigned_too_few_test_positives +15781,63831,18.227753,0.7680664,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.7680664,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5672293795350215,0.1688819967508492,0.002658396101019052,0.16666666666666666,63.52777777777777,2.0,15.0,32.71385459533608,0.002922504736186225,Active-site capping loop,True,assigned_and_evaluated +15782,85762,35.595154,0.92041016,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9145508,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,12.0,12.0,205.58965517241379,4.745472356953812e-28,Plant carotenoid cyclase core motif,True,assigned_too_few_test_positives +15783,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended disordered interaction regions,False,no_term_above_threshold +15784,38317,20.014261,0.9589844,Pentatricopeptide repeat,interpro,87384,DNA-binding,0.66845703,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.8907936507936507,0.01556100966733584,0.0031014621178555605,,5.017314117025284,0.0,12.0,0.0,1.0,OmpR/PhoB signature motifs,True,assigned_and_evaluated +15785,87158,16.069822,0.7207031,Antibiotic,keyword,87158,Antibiotic,0.7207031,472,keywords,Antibiotic,keyword:keywords:Antibiotic,43.0,2257.0,0.7112770740110501,0.031243648107009393,0.01905183872396987,,1.6399282273841906,0.0,20.0,0.0,1.0,Exposed protein termini detector,True,assigned_and_evaluated +15786,37894,19.982933,0.9609375,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.81591797,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,SDR motif-2 αE helix,True,assigned_too_few_test_positives +15787,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Clamshell LBD beta-strand hotspots,False,no_term_above_threshold +15788,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein N-terminal ectodomain,False,no_term_above_threshold +15789,38317,16.223507,0.9477539,Pentatricopeptide repeat,interpro,82608,Ankyrin repeat-containing domain,0.8828125,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9124444444444444,0.11524449647044088,0.0031014621178555605,,37.158118361969294,0.0,16.0,0.0,1.0,Internal helical-repeat scaffolds,True,assigned_and_evaluated +15790,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic–basic interaction hotspot,False,no_term_above_threshold +15791,36914,23.562643,0.9223633,Glycosyltransferase 2-like,interpro,36914,Glycosyltransferase 2-like,0.9223633,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,0.0,10.0,0.0,1.0,Extracellular membrane-proximal linkers,True,assigned_too_few_test_positives +15792,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich low-complexity IDRs,False,no_term_above_threshold +15793,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored beta-strand repeats,False,no_term_above_threshold +15794,38654,18.968967,0.7675781,B3 DNA binding domain,interpro,38654,B3 DNA binding domain,0.7675781,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,5.0,0.0,1.0,Bacterial replisome coupling helices,True,assigned_too_few_test_positives +15795,36977,17.747187,0.9707031,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.90771484,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,8.0,16.0,155.26302083333334,3.0108361393140526e-16,Kinase activation-loop Aspartate,True,assigned_too_few_test_positives +15796,82029,28.681442,0.99902344,MFS general substrate transporter like domains,gene3d,88162,Transport,0.6044922,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,20.0,178.67492113564668,7.679658738454228e-42,Small-residue TM hinge motifs,True,assigned_too_few_test_positives +15797,45714,19.007666,0.98291016,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,64381,Helix-loop-helix DNA-binding domain superfamily,0.9707031,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,15.0,0.0,1.0,Post-His DHp alpha-helix,True,assigned_too_few_test_positives +15798,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic TM boundaries and tails,False,no_term_above_threshold +15799,87697,19.197681,0.8691406,Knottin,keyword,87413,Disulfide bond,0.66845703,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9177995884488221,0.10604417965693934,0.017279574656623838,,6.136967012454156,0.0,18.0,0.0,1.0,Aliphatic β-strand core detector,True,assigned_and_evaluated +15800,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular carbohydrate-binding modules,False,no_term_above_threshold +15801,36886,25.53673,0.9760742,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9760742,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9354713205869276,0.5543121136358842,0.003544528134692069,0.875,156.38530505952383,19.0,20.0,222.11745098039214,1.5620311737595424e-43,Fungal TF helical regulatory core,True,assigned_and_evaluated +15802,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Actinobacterial low-complexity termini,False,no_term_above_threshold +15803,-1,,,,,-1,,,0,,,,,,,,,,,,,,,O-glycosylated low-complexity linkers,False,no_term_above_threshold +15804,55053,18.724041,0.98535156,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,3.0,14.0,118.29563492063491,3.950279378284059e-06,Biotin carboxylase PSPG loop,True,assigned_too_few_test_positives +15805,87857,20.502508,0.6616211,Nucleus,keyword,24917,nucleus,0.6591797,1713,keywords,Nucleus,keyword:keywords:Nucleus,141.0,2257.0,0.7419207255761573,0.17680699270201355,0.06247230837394772,,2.830165833535068,4.0,20.0,1.211808943089431,0.6628588615021606,S/T-rich low-complexity IDRs,True,assigned_and_evaluated +15806,85649,36.36277,0.82470703,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.82421875,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.6715581331983963,0.29512080046648825,0.0101905183872397,0.30434782608695654,28.960332463167997,8.0,15.0,58.99418676561533,5.7477673580722e-13,RNA-biased SAM MTase core,True,assigned_and_evaluated +15807,36104,16.651648,0.8276367,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.8276367,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Extracellular enzyme C-terminal loops,True,assigned_too_few_test_positives +15808,88164,16.416588,0.7207031,Transposition,keyword,88164,Transposition,0.7207031,52,keywords,Transposition,keyword:keywords:Transposition,5.0,2257.0,0.49489342806394315,0.002215330084182543,0.002215330084182543,,1.0,2.0,12.0,121.18089430894308,0.00022224040934482362,Serine recombinase C-terminal HTH,True,assigned_and_evaluated +15809,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site rim beta-loop-alpha module,False,no_term_above_threshold +15810,55054,18.38467,0.9760742,HAD superfamily,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6645508,39,ip,IPR023214,interpro:ip:IPR023214,5.0,2257.0,0.8899200710479575,0.26330020887397937,0.002215330084182543,0.4,118.85371428571429,0.0,17.0,0.0,1.0,REC D+1 and DHp H+1,True,assigned_and_evaluated +15811,25079,34.2816,0.6455078,plasma membrane,go_cc,88161,Transmembrane helix,0.62939453,2373,go,GO:0005886,go_cc:go:GO:0005886,276.0,2257.0,0.7518746936476234,0.4391045709010696,0.12228622064687639,0.5579710144927537,3.5907935381293985,9.0,15.0,3.794696085711255,0.00022414773801997478,TM helix-loop junction,True,assigned_and_evaluated +15812,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligase/GTase nucleotidyltransferase core,False,no_term_above_threshold +15813,37312,16.622856,1.0,"DNA-binding HTH domain, TetR-type",interpro,81540,"Tetracycline Repressor, domain 2",1.0,29,ip,IPR001647,interpro:ip:IPR001647,,,,,,,,18.0,19.0,818.5949656750571,4.3313349653425253e-51,Amphipathic dimerization helices,True,assigned_too_few_test_positives +15814,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Scaffold protein internal regions,False,no_term_above_threshold +15815,88154,18.432768,0.8540039,Transit peptide,keyword,88058,Signal,0.7446289,239,keywords,Transit peptide,keyword:keywords:Transit peptide,24.0,2257.0,0.7637054037916108,0.023415189654134555,0.010633584404076208,,2.2020034603909036,2.0,18.0,3.2441506148655996,0.2004979407229864,Basic N-terminal targeting patch,True,assigned_and_evaluated +15816,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical scaffold and functional residues,False,no_term_above_threshold +15817,59229,30.92905,0.9770508,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9770508,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9660776147288934,0.7525237753396865,0.0101905183872397,0.7391304347826086,73.84548525833358,16.0,16.0,106.27629233511585,1.339381655082284e-32,Motif I-adjacent hydrophobic helix,True,assigned_and_evaluated +15818,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal membrane-proximal activation,False,no_term_above_threshold +15819,85664,21.812536,0.98046875,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.98046875,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,15.0,15.0,331.22777777777776,5.878944770543747e-38,Glycosyltransferase donor-sugar loop,True,assigned_too_few_test_positives +15820,36776,16.468657,0.9902344,SANT/Myb domain,interpro,43624,Homedomain-like superfamily,0.9760742,45,ip,IPR001005,interpro:ip:IPR001005,6.0,2257.0,0.9727528505849252,0.052387239270691645,0.002658396101019052,,19.706333172325174,0.0,17.0,0.0,1.0,Recognition helix boundary turn,True,assigned_and_evaluated +15821,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site loop/lid segments,False,no_term_above_threshold +15822,38873,23.109953,0.9345703,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8847656,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9962699822380107,0.6764705882352942,0.002215330084182543,0.6,305.3588235294118,12.0,12.0,171.32471264367817,4.232415391986194e-27,ABC NBD post-Walker A segment,True,assigned_and_evaluated +15823,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured functional domain cores,False,no_term_above_threshold +15824,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PINc RNase scaffold detector,False,no_term_above_threshold +15825,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-strand turn motifs,False,no_term_above_threshold +15826,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Exposed strand-loop-helix motifs,False,no_term_above_threshold +15827,50338,15.593391,0.9824219,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6333008,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,12.0,0.0,1.0,Hydrophobic TM helix faces,True,assigned_too_few_test_positives +15828,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FNR-like FAD-binding domain,False,no_term_above_threshold +15829,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity disordered repeats,False,no_term_above_threshold +15830,87326,25.315435,0.6386719,Coiled coil,keyword,87326,Coiled coil,0.6386719,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6895600978481694,0.34538538089917453,0.03943287549844927,0.34831460674157305,8.758818030218393,19.0,19.0,12.607528018608585,3.1804487015974775e-21,N-terminal coiled-coil oligomerization/docking module,True,assigned_and_evaluated +15831,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic S/T/P/G-rich IDRs,False,no_term_above_threshold +15832,64003,26.266142,0.97558594,Zinc finger C2H2 superfamily,interpro,46932,Zinc finger C2H2-type,0.96875,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,19.0,19.0,130.4617067833698,3.819237356487831e-40,C2H2 ZF linker tail preference,True,assigned_and_evaluated +15833,88160,17.729479,0.79589844,Transmembrane beta strand,keyword,25167,cell outer membrane,0.66064453,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,13.0,16.0,235.15564320388347,1.4007539360355413e-29,Outer membrane beta-barrel translocators,True,assigned_too_few_test_positives +15834,87925,16.300085,0.71484375,Plant defense,keyword,87925,Plant defense,0.71484375,171,keywords,Plant defense,keyword:keywords:Plant defense,13.0,2257.0,0.7126011243658303,0.058038464770375456,0.0057598582188746125,,10.076370383595185,0.0,12.0,0.0,1.0,Plant P/S/T-rich disordered glycomodules,True,assigned_and_evaluated +15835,85672,22.221365,0.63623047,P-loop containing nucleotide triphosphate hydrolases,gene3d,85672,P-loop containing nucleotide triphosphate hydrolases,0.63623047,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6074778628245535,0.12434367915925293,0.01595037660611431,0.19444444444444445,7.795657885067608,11.0,11.0,40.01409395973155,5.684857690301746e-18,Post Walker A helicase helix,True,assigned_and_evaluated +15836,36091,16.303984,0.7324219,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.7192383,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,11.0,16.0,259.4268196202532,4.156766494593421e-25,GNAT CoA/ACP-binding surface,True,assigned_too_few_test_positives +15837,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad polar surface activation,False,no_term_above_threshold +15838,64599,15.735727,0.9916992,Chaperone J-domain superfamily,interpro,81685,Transferase(Phosphotransferase) domain 1,0.8666992,28,ip,IPR036869,interpro:ip:IPR036869,,,,,,,,9.0,9.0,662.4555555555555,8.40484455778576e-26,J-domain HPD motif recognition,True,assigned_too_few_test_positives +15839,87326,40.713734,0.7661133,Coiled coil,keyword,87326,Coiled coil,0.7661133,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.8083176126705088,0.3610430615917702,0.03943287549844927,0.38202247191011235,9.155889775422757,18.0,20.0,11.346775216747726,6.031390779229954e-18,Coiled-coil rod domains,True,assigned_and_evaluated +15840,63951,19.759487,0.9682617,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.96533203,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9972815342032424,0.6438746438746439,0.003987594151528578,0.7777777777777778,161.46945235834124,15.0,18.0,134.28153153153156,1.8206969678277143e-30,Ectodomain β-sandwich β-strands,True,assigned_and_evaluated +15841,63774,18.082792,0.9536133,RNA-binding domain superfamily,interpro,63774,RNA-binding domain superfamily,0.9536133,69,ip,IPR035979,interpro:ip:IPR035979,,,,,,,,0.0,18.0,0.0,1.0,β-strand–loop capping motifs,True,assigned_too_few_test_positives +15842,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diiron carboxylate ligand helices,False,no_term_above_threshold +15843,38654,19.200094,0.8613281,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.8588867,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,13.0,0.0,1.0,C-terminal LRRs and tail,True,assigned_too_few_test_positives +15844,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved LGIEKVV hinge motif,False,no_term_above_threshold +15845,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta/alpha assembly interface,False,no_term_above_threshold +15846,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SH2 domain fold recognition,False,no_term_above_threshold +15847,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Plant polarity coiled-coil tethers,False,no_term_above_threshold +15848,87326,24.726688,0.6411133,Coiled coil,keyword,87326,Coiled coil,0.6411133,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6623486670259962,0.1211019422571796,0.03943287549844927,0.02247191011235955,3.071090827802858,7.0,17.0,5.1913350664858875,0.0003387372001237289,Coiled-coil oligomerization domains,True,assigned_and_evaluated +15849,64016,24.21066,0.9980469,Thioredoxin-like superfamily,interpro,85388,Glutaredoxin,0.9980469,70,ip,IPR036249,interpro:ip:IPR036249,7.0,2257.0,0.9972063492063491,0.3909786641929499,0.0031014621178555605,0.14285714285714285,126.06269215478399,10.0,16.0,138.5246282527881,5.978793516315413e-20,Cys/Sec redox/metal motifs,True,assigned_and_evaluated +15850,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coil oligomerization interfaces,False,no_term_above_threshold +15851,36886,15.697879,0.85595703,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,87767,Metal-binding,0.62158203,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8958703868385949,0.03441291352511611,0.003544528134692069,,9.708743228273383,0.0,13.0,0.0,1.0,Ferredoxin-like Fe-S distal regions,True,assigned_and_evaluated +15852,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-helix interface motifs,False,no_term_above_threshold +15853,36914,21.411186,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.93066406,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,16.0,16.0,736.0617283950618,7.329763891109132e-46,Glycosyltransferase phosphate-anchoring motif,True,assigned_too_few_test_positives +15854,45288,21.686207,1.0,CheY-like superfamily,interpro,85669,3.40.50.2300,0.8222656,31,ip,IPR011006,interpro:ip:IPR011006,,,,,,,,16.0,16.0,462.17829457364337,1.1105476792425275e-42,REC β3 phospho-Asp motif,True,assigned_too_few_test_positives +15855,85682,15.706674,0.80029297,NAD(P)-binding Rossmann-like Domain,gene3d,88153,Transferase,0.65185547,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.949247311827957,0.12746469887466672,0.011076650420912717,,11.50751301440491,0.0,12.0,0.0,1.0,Non-catalytic aromatic amphipathic helices,True,assigned_and_evaluated +15856,37894,21.997496,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,64058,NAD(P)-binding domain superfamily,0.79785156,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,11.0,11.0,709.7738095238095,9.193019285517015e-32,Rossmann-like dimer-interface helix,True,assigned_too_few_test_positives +15857,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ApcE bilin-binding region,False,no_term_above_threshold +15858,85364,23.601572,0.9951172,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9951172,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,Venus flytrap ligand-binding cleft,True,assigned_too_few_test_positives +15859,37341,21.676994,0.9980469,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9946289,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.999634612190666,0.952932825526807,0.011962782454585734,1.0,79.6581254523705,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD propeller E-to-coil motif,True,assigned_and_evaluated +15860,87326,31.842152,0.68603516,Coiled coil,keyword,87326,Coiled coil,0.68603516,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7509950661304367,0.3000183434576293,0.03943287549844927,0.4157303370786517,7.608330350380554,13.0,20.0,8.19489321209558,4.5929025059208627e-10,Internal coiled-coil dimerization helices,True,assigned_and_evaluated +15861,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic β-hairpin motif,False,no_term_above_threshold +15862,8305,16.337603,0.75341797,fatty acid biosynthetic process,go_bp,8305,fatty acid biosynthetic process,0.75341797,31,go,GO:0006633,go_bp:go:GO:0006633,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,12.0,15.0,224.98490566037736,4.395775013972065e-27,Thiolase/ketosynthase-like condensing/cleaving domain,True,assigned_and_evaluated +15863,81685,17.45258,0.86572266,Transferase(Phosphotransferase) domain 1,gene3d,45290,Protein kinase-like domain superfamily,0.83691406,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.8675946547884186,0.5193767669748163,0.005316792202038104,0.4166666666666667,97.68611358851335,9.0,9.0,85.66235632183908,9.44289264828213e-18,Kinase C-terminal regulatory tail detector,True,assigned_and_evaluated +15864,36668,16.417622,0.9848633,AMP-dependent synthetase/ligase domain,interpro,36668,AMP-dependent synthetase/ligase domain,0.9848633,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,13.0,13.0,532.3303571428571,9.561000563003835e-36,ANL adenylation motif detector,True,assigned_too_few_test_positives +15865,42974,17.114187,0.9121094,"Serine/threonine-protein kinase, active site",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.6176758,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9246984126984127,0.2314392523701657,0.0031014621178555605,,74.62262751420914,0.0,10.0,0.0,1.0,ABC signature LSGGQ motif,True,assigned_and_evaluated +15866,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Long helical scaffold tethers,False,no_term_above_threshold +15867,38317,26.0754,0.95751953,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.95751953,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.9884444444444445,0.17994447779111644,0.0031014621178555605,,58.01924091064997,0.0,14.0,0.0,1.0,Protein kinase C-lobe helices,True,assigned_and_evaluated +15868,38890,18.4748,0.99853516,HNH nuclease,interpro,88263,Zinc-finger,0.6767578,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,12.0,20.0,777.6652173913044,5.2425648789446515e-33,Metal-dependent nuclease beta–alpha junction,True,assigned_too_few_test_positives +15869,50869,22.335653,1.0,"DNA binding HTH domain, AraC-type",interpro,88263,Zinc-finger,0.8354492,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,15.0,0.0,1.0,C2H2 zinc-finger recognition helix,True,assigned_too_few_test_positives +15870,85364,15.621452,0.75927734,Periplasmic binding protein-like II,gene3d,64148,Winged helix DNA-binding domain superfamily,0.6904297,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,12.0,17.0,212.55258467023177,2.4836502743824046e-26,HTH two-helix hairpin,True,assigned_too_few_test_positives +15871,80926,25.439186,0.98779297,Homeodomain-like,gene3d,87384,DNA-binding,0.734375,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.9894419306184012,0.3074587540384469,0.0057598582188746125,0.23076923076923078,53.379569835751894,14.0,18.0,74.19502222222222,1.469640862944473e-24,Helical DNA-binding interfaces,True,assigned_and_evaluated +15872,45714,17.691935,1.0,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",1.0,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,15.0,15.0,298.105,2.8182404069817456e-37,Disordered transcriptional effector tails,True,assigned_too_few_test_positives +15873,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical core motif,False,no_term_above_threshold +15874,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged coiled-coil arm scaffolds,False,no_term_above_threshold +15875,80926,17.147701,0.6503906,Homeodomain-like,gene3d,43624,Homedomain-like superfamily,0.64404297,186,gene3d,1.10.10.60,gene3d:gene3d:1.10.10.60,13.0,2257.0,0.4910873440285205,0.0057598582188746125,0.0057598582188746125,,1.0,15.0,15.0,95.39359999999999,6.442923539677364e-30,Acidic Ser/Thr-rich IDRs,True,assigned_and_evaluated +15876,39971,16.703978,0.7919922,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,39971,"Calcineurin-like phosphoesterase domain, ApaH type",0.7919922,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,0.0,11.0,0.0,1.0,CAZyme N-terminal accessory region,True,assigned_too_few_test_positives +15877,46929,28.13132,0.8886719,"Zinc finger, RING/FYVE/PHD-type",interpro,88263,Zinc-finger,0.73046875,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9963587921847246,0.2767676767676768,0.002215330084182543,,124.9329292929293,17.0,19.0,76.86614591233126,7.1904443229817576e-31,PHD-related Cys/His zinc mini-domains,True,assigned_and_evaluated +15878,82716,16.768064,0.9848633,Laminin,gene3d,87413,Disulfide bond,0.78027344,67,gene3d,2.10.25.10,gene3d:gene3d:2.10.25.10,,,,,,,,17.0,17.0,289.42233009708735,7.848216272787399e-42,Extracellular cysteine-rich repeats,True,assigned_too_few_test_positives +15879,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Deubiquitinase catalytic domains,False,no_term_above_threshold +15880,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical interaction surfaces,False,no_term_above_threshold +15881,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved AnPRT N-terminal motif,False,no_term_above_threshold +15882,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Organellar precursor N-terminal signature,False,no_term_above_threshold +15883,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored short structural segments,False,no_term_above_threshold +15884,50338,16.15028,0.98339844,"GPCR, rhodopsin-like, 7TM",interpro,88161,Transmembrane helix,0.6777344,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,0.0,19.0,0.0,1.0,TM helix caps and loops,True,assigned_too_few_test_positives +15885,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PCNA/beta-clamp interaction motifs,False,no_term_above_threshold +15886,49061,16.936106,0.64501953,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.64501953,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.6379542395693136,0.2272987181791623,0.012405848471422242,0.17857142857142858,18.32190024751319,10.0,19.0,52.03892816618661,2.0851085886726235e-15,Beta-propeller sensory/scaffold domains,True,assigned_and_evaluated +15887,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic beta-strand hydrophobes,False,no_term_above_threshold +15888,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal helix-rich active-site scaffold,False,no_term_above_threshold +15889,87697,17.944445,0.85595703,Knottin,keyword,88058,Signal,0.8095703,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9539606020670042,0.18881786642745896,0.017279574656623838,,10.927228834019868,0.0,20.0,0.0,1.0,Signal peptide cleavage-site recognition,True,assigned_and_evaluated +15890,88160,18.101038,0.78564453,Transmembrane beta strand,keyword,25167,cell outer membrane,0.6611328,52,keywords,Transmembrane beta strand,keyword:keywords:Transmembrane beta strand,,,,,,,,14.0,15.0,270.12750809061487,1.5439096625884537e-33,Outer-membrane beta-barrel channels,True,assigned_too_few_test_positives +15891,82608,15.846784,0.7060547,Ankyrin repeat-containing domain,gene3d,82608,Ankyrin repeat-containing domain,0.7060547,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,0.5425744775455758,0.004746198959960824,0.003544528134692069,,1.3390213815789473,0.0,20.0,0.0,1.0,Gly-aromatic beta-edge loops,True,assigned_and_evaluated +15892,31094,15.937155,0.9765625,phosphopantetheine binding,go_mf,36668,AMP-dependent synthetase/ligase domain,0.92333984,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.9834890965732087,0.3086199409600411,0.004430660168365086,0.2,69.65552067468128,1.0,15.0,47.31825396825397,0.0352196017772138,Anion-binding flexible lid loops,True,assigned_and_evaluated +15893,58239,16.50274,0.66552734,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.66552734,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.7284393324312133,0.069184058964052,0.017722640673460344,,3.903710527046634,0.0,17.0,0.0,1.0,PRTase AKPxG scaffolding loop,True,assigned_and_evaluated +15894,38890,16.589323,0.9897461,HNH nuclease,interpro,29166,zinc ion binding,0.85009766,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,1.0,17.0,76.24168797953965,0.022148019768533554,Cys-rich metal-binding linkers,True,assigned_too_few_test_positives +15895,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane β-barrel strands,False,no_term_above_threshold +15896,87913,15.725232,0.8203125,Phosphopantetheine,keyword,87913,Phosphopantetheine,0.8203125,49,keywords,Phosphopantetheine,keyword:keywords:Phosphopantetheine,14.0,2257.0,0.8473027195720019,0.1800000869415868,0.006202924235711121,,29.018585444797246,0.0,17.0,0.0,1.0,PCMH-type FAD-binding core,True,assigned_and_evaluated +15897,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic Ser/Thr-rich IDRs,False,no_term_above_threshold +15898,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic SP/TP-rich regulatory IDRs,False,no_term_above_threshold +15899,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipid-handling pan-protein activation,False,no_term_above_threshold +15900,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-assisted phosphate-binding interface,False,no_term_above_threshold +15901,85664,19.53193,0.9663086,Glycogen Phosphorylase B;,gene3d,85388,Glutaredoxin,0.86035156,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,17.0,0.0,1.0,REC α5 hydrophobic helix face,True,assigned_too_few_test_positives +15902,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interdomain signaling helices,False,no_term_above_threshold +15903,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNR alpha C-terminal catalytic block,False,no_term_above_threshold +15904,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM juxtamembrane caps,False,no_term_above_threshold +15905,87695,16.342188,0.75097656,Kinetochore,keyword,87695,Kinetochore,0.75097656,31,keywords,Kinetochore,keyword:keywords:Kinetochore,6.0,2257.0,0.7437065008144529,0.07513872186003334,0.002658396101019052,,28.26468253968254,0.0,20.0,0.0,1.0,Charged helical docking arms,True,assigned_and_evaluated +15906,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Small acidic disordered regulators,False,no_term_above_threshold +15907,87409,17.811565,0.84277344,Dioxygenase,keyword,48241,RmlC-like jelly roll fold,0.8261719,36,keywords,Dioxygenase,keyword:keywords:Dioxygenase,,,,,,,,11.0,13.0,236.8475984109787,2.2147867107577503e-25,Facial-triad DSBH oxygenase core,True,assigned_too_few_test_positives +15908,85682,16.191525,0.74072266,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.74072266,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8663620071684588,0.11395961589578213,0.011076650420912717,,10.28827412307121,1.0,15.0,6.817724413950828,0.21862323143570717,Glycine-rich active-site lids,True,assigned_and_evaluated +15909,8200,17.30109,0.6845703,proteolysis,go_bp,88058,Signal,0.6279297,331,go,GO:0006508,go_bp:go:GO:0006508,24.0,2257.0,0.7442901925660548,0.04520204032628014,0.010633584404076208,,4.250875209017261,2.0,16.0,6.024757477768795,0.07041482431566148,Active-site connector loops,True,assigned_and_evaluated +15910,64058,29.50518,0.7480469,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7397461,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.8901980765556333,0.5895828755899013,0.006202924235711121,0.5,95.04918215760051,16.0,16.0,113.99808795411089,4.441314123773332e-33,Adenosine cofactor-binding loop,True,assigned_and_evaluated +15911,85682,16.345436,0.6254883,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6254883,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.6158781362007169,0.09112821102985039,0.011076650420912717,0.12,8.227054891774893,16.0,16.0,102.26586620926243,2.472580145272991e-32,Rossmann interdomain linker lid,True,assigned_and_evaluated +15912,38317,28.033146,0.9790039,Pentatricopeptide repeat,interpro,82597,Tetratricopeptide repeat domain,0.93066406,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7825396825396825,0.23744030916162062,0.0031014621178555605,0.2857142857142857,76.55753968253967,0.0,18.0,0.0,1.0,Alpha-solenoid helical repeat scaffolds,True,assigned_and_evaluated +15913,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-interface loop-helix motifs,False,no_term_above_threshold +15914,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SLiM/boundary and catalytic-helix detector,False,no_term_above_threshold +15915,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C2B and RabBD loop signal,False,no_term_above_threshold +15916,36115,28.330217,0.99853516,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.99853516,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,9.0,0.0,1.0,Helical oligomerization interface detector,True,assigned_too_few_test_positives +15917,72011,17.777126,0.9589844,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.9316406,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,14.0,0.0,1.0,SAM-binding RNA methyltransferase core,True,assigned_too_few_test_positives +15918,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NB-ARC amphipathic helix-loop-helix,False,no_term_above_threshold +15919,36499,15.689495,0.9448242,"Zinc finger, GATA-type",interpro,88263,Zinc-finger,0.74902344,35,ip,IPR000679,interpro:ip:IPR000679,,,,,,,,0.0,16.0,0.0,1.0,Short zinc-binding loop patches,True,assigned_too_few_test_positives +15920,37020,19.412119,0.8725586,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.7626953,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,5.0,14.0,291.68786692759295,1.0304191794348835e-11,Leloir hexosyltransferase catalytic core,True,assigned_too_few_test_positives +15921,-1,,,,,-1,,,0,,,,,,,,,,,,,,,AspRS C-terminal conserved motif,False,no_term_above_threshold +15922,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane protein terminal IDRs,False,no_term_above_threshold +15923,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal signal-anchor helix,False,no_term_above_threshold +15924,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting/processing signals,False,no_term_above_threshold +15925,38654,18.580847,0.82666016,B3 DNA binding domain,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.81347656,35,ip,IPR003340,interpro:ip:IPR003340,,,,,,,,0.0,15.0,0.0,1.0,NTP-handling helical scaffold,True,assigned_too_few_test_positives +15926,36876,17.586134,1.0,Cytochrome P450,interpro,36876,Cytochrome P450,1.0,35,ip,IPR001128,interpro:ip:IPR001128,9.0,2257.0,1.0,1.0000000000000002,0.003987594151528578,1.0,250.77777777777786,18.0,18.0,389.6797385620915,2.4234264751426887e-46,Cytochrome P450 catalytic core,True,assigned_and_evaluated +15927,85682,39.13038,0.82470703,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.82470703,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.8164695340501793,0.5119480895947828,0.011076650420912717,0.64,46.21867352861699,17.0,17.0,102.26586620926243,2.6394552661124587e-34,N-terminal Rossmann NAD(P)+ motif,True,assigned_and_evaluated +15928,37314,16.229906,0.99365234,"Helicase, C-terminal domain-like",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6020508,37,ip,IPR001650,interpro:ip:IPR001650,,,,,,,,4.0,5.0,253.70638297872344,9.900293647960033e-10,C-terminal helical interaction module,True,assigned_too_few_test_positives +15929,36535,16.405403,0.90722656,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9003906,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9468402314196707,0.763277290615767,0.004430660168365086,0.7,172.27168449197862,13.0,13.0,89.79066265060241,1.1174852366600676e-25,Disordered kinase regulatory tails,True,assigned_and_evaluated +15930,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helices and interfaces,False,no_term_above_threshold +15931,36886,22.359858,0.95703125,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.95703125,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8724433081369498,0.49369748734502833,0.003544528134692069,0.625,139.28440361721613,18.0,18.0,233.80784313725488,1.5159322438572416e-42,C-terminal disordered activation tails,True,assigned_and_evaluated +15932,36091,21.836967,1.0,GNAT domain,interpro,37446,F-box domain,0.94433594,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,17.0,17.0,377.3481012658228,1.0362764569171756e-43,GNAT glycine-rich CoA-binding loop,True,assigned_too_few_test_positives +15933,48767,17.975649,0.98876953,DNA-binding pseudobarrel domain superfamily,interpro,48767,DNA-binding pseudobarrel domain superfamily,0.98876953,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,1.0,14.0,66.54129464285714,0.02526699302648215,Disordered transcription factor tails,True,assigned_too_few_test_positives +15934,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site metal-binding loop,False,no_term_above_threshold +15935,38317,25.383055,0.9213867,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.9213867,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.692888888888889,0.015078013196265894,0.0031014621178555605,,4.86158225485316,0.0,10.0,0.0,1.0,ABC NBD C-loop signature,True,assigned_and_evaluated +15936,85364,20.87683,0.9946289,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.9946289,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,Clamshell ligand-binding hinge loops,True,assigned_too_few_test_positives +15937,36535,22.638998,0.9604492,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.953125,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9492211838006229,0.9004430660168364,0.004430660168365086,0.9,203.23,18.0,18.0,89.79066265060241,2.921620089201569e-35,Conserved kinase C-lobe helix,True,assigned_and_evaluated +15938,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal basic NLS motif,False,no_term_above_threshold +15939,81799,17.713314,0.9819336,1.10.8.60,gene3d,45551,SKP1/BTB/POZ domain superfamily,0.8720703,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,10.0,13.0,445.26512322628827,1.3301318535078167e-25,AAA+ post Walker A motif,True,assigned_too_few_test_positives +15940,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-centric energy metabolism enzymes,False,no_term_above_threshold +15941,85664,16.946102,0.96777344,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.96777344,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,18.0,18.0,331.22777777777776,3.831366179140002e-45,Conserved glycosyltransferase hinge loop,True,assigned_too_few_test_positives +15942,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic mobile loops and tails,False,no_term_above_threshold +15943,37341,24.219187,0.99902344,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9765625,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9999003487792726,0.9913131039056964,0.011962782454585734,1.0,82.86643242648728,19.0,19.0,145.4170731707317,5.254240088122417e-41,WD40 blade WD/YD motif,True,assigned_and_evaluated +15944,37894,23.91975,0.97998047,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7783203,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,10.0,15.0,473.18253968253964,1.6267926303022185e-25,SDR oligomerization interface helix,True,assigned_too_few_test_positives +15945,28225,19.528648,0.8129883,metalloendopeptidase activity,go_mf,87770,Metalloprotease,0.7055664,41,go,GO:0004222,go_mf:go:GO:0004222,,,,,,,,6.0,17.0,107.3607442977191,3.011320777824636e-11,SprT/WLM fold and exosites,True,assigned_too_few_test_positives +15946,72011,15.747396,0.9794922,"AMP-binding enzyme, C-terminal domain superfamily",interpro,36668,AMP-dependent synthetase/ligase domain,0.9248047,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,17.0,0.0,1.0,Acidic C-terminal activation domains,True,assigned_too_few_test_positives +15947,87326,31.023275,0.6503906,Coiled coil,keyword,87326,Coiled coil,0.6503906,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.662980948629711,0.2666890030592799,0.03943287549844927,0.2808988764044944,6.763113257357245,17.0,19.0,11.28041980612347,6.733872062658451e-17,Long coiled-coil scaffolds,True,assigned_and_evaluated +15948,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TCTP-centric small-protein activation,False,no_term_above_threshold +15949,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Motif-flanking capping residues,False,no_term_above_threshold +15950,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sulfatase C-terminal WKPCC motif,False,no_term_above_threshold +15951,88058,27.841713,0.6464844,Signal,keyword,88058,Signal,0.6464844,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6182219897468912,0.14655832360282758,0.09127159946832078,0.019417475728155338,1.60573852607564,12.0,19.0,4.550497694387024,1.89130523558192e-06,Ser/Thr-enriched beta-sheet signature,True,assigned_and_evaluated +15952,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ser/Thr/Gly-rich export interfaces,False,no_term_above_threshold +15953,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed polar helices,False,no_term_above_threshold +15954,37690,35.211414,0.9589844,Ankyrin repeat,interpro,64507,Ankyrin repeat-containing domain superfamily,0.9404297,112,ip,IPR002110,interpro:ip:IPR002110,7.0,2257.0,0.9906666666666667,0.1614871970135128,0.0031014621178555605,,52.0680862370712,0.0,17.0,0.0,1.0,CA-domain Bergerat helix,True,assigned_and_evaluated +15955,37894,17.751427,0.98046875,Short-chain dehydrogenase/reductase SDR,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.84033203,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,9.0,9.0,709.7738095238095,4.424699527134814e-26,SDR internal Rossmann helix,True,assigned_too_few_test_positives +15956,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal interaction helices,False,no_term_above_threshold +15957,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ASL C-terminal Gly-Gly motif,False,no_term_above_threshold +15958,85664,15.694416,0.9658203,Glycogen Phosphorylase B;,gene3d,85388,Glutaredoxin,0.91308594,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,0.0,19.0,0.0,1.0,TCS REC output face,True,assigned_too_few_test_positives +15959,47717,16.706875,0.9448242,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7709961,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,0.0,10.0,0.0,1.0,ABC ATPase H-loop switch,True,assigned_too_few_test_positives +15960,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Metal-dependent polyanion-binding catalytic cores,False,no_term_above_threshold +15961,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal PAF-AH signature,False,no_term_above_threshold +15962,55053,20.45358,0.98535156,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.98535156,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,15.0,478.4401234567901,5.378000991812425e-34,Acyl-handling lid helices,True,assigned_too_few_test_positives +15963,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic membrane-insertion segments,False,no_term_above_threshold +15964,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pro/Ser-rich alternative exon motif,False,no_term_above_threshold +15965,87697,26.72353,0.7475586,Knottin,keyword,87697,Knottin,0.7475586,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.8157036831518346,0.3792417555859879,0.017279574656623838,0.6410256410256411,21.947401086091656,0.0,18.0,0.0,1.0,SGNH/GDSL esterase catalytic core,True,assigned_and_evaluated +15966,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PG/chitin and DHPS catalytic signature,False,no_term_above_threshold +15967,46929,21.153934,0.92089844,"Zinc finger, RING/FYVE/PHD-type",interpro,29166,zinc ion binding,0.8535156,152,ip,IPR013083,interpro:ip:IPR013083,5.0,2257.0,0.9740674955595028,0.24748954498785466,0.002215330084182543,0.2,111.7167806075176,1.0,15.0,5.727281460134486,0.25589652783541306,Cys/His-rich zinc fingers,True,assigned_and_evaluated +15968,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Fusion-core coiled-coil tethers,False,no_term_above_threshold +15969,82029,30.660599,0.984375,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.96435547,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,N-terminal pre-TM1 positive-inside signal,True,assigned_too_few_test_positives +15970,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Serine/threonine-rich disordered linkers,False,no_term_above_threshold +15971,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide-sugar pyrophosphorylase C-terminal oligomerization,False,no_term_above_threshold +15972,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Adenine/redox cofactor-binding cores,False,no_term_above_threshold +15973,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Gly/Pro-rich periplasmic hinge/lid,False,no_term_above_threshold +15974,47529,19.87692,0.734375,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.734375,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.7730784248103525,0.25102340037696486,0.007089056269384138,0.25,35.409988415675606,17.0,18.0,73.03336215593025,4.719214826677225e-31,GH2 sugar-binding beta-strand,True,assigned_and_evaluated +15975,36272,15.939889,0.92089844,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.92089844,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,20.0,0.0,1.0,Tyrosine recombinase N-terminal DNA-binding arm,True,assigned_too_few_test_positives +15976,55053,22.99603,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,13.0,14.0,512.614417989418,7.55716403384954e-35,C-domain hydrophobic helix,True,assigned_too_few_test_positives +15977,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Amphipathic helical repeat segments,False,no_term_above_threshold +15978,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM–cytoplasmic juxtamembrane linker helix,False,no_term_above_threshold +15979,85672,27.627296,0.8491211,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.84228516,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.8446270448746811,0.12647907535508016,0.01595037660611431,,7.929535363233776,0.0,16.0,0.0,1.0,TIM-barrel active-site flanking hotspots,True,assigned_and_evaluated +15980,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ATP-grasp and formyltransferase catalytic domains,False,no_term_above_threshold +15981,45290,32.353195,0.97314453,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.97314453,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9608014534485122,0.9176028293304457,0.0057598582188746125,0.9230769230769231,159.30996813837044,17.0,17.0,73.42487684729065,6.829036441178294e-32,Kinase beta-to-alpha N-cap,True,assigned_and_evaluated +15982,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic PEST-like IDRs,False,no_term_above_threshold +15983,87465,25.734068,0.94384766,Fimbrium,keyword,87465,Fimbrium,0.94384766,47,keywords,Fimbrium,keyword:keywords:Fimbrium,5.0,2257.0,0.7964476021314387,0.338386132033673,0.002215330084182543,0.4,152.7475,6.0,17.0,182.98005115089515,1.2119653466839449e-12,Basic N-terminal signal leaders,True,assigned_and_evaluated +15984,36535,22.786375,0.96191406,Protein kinase domain,interpro,45290,Protein kinase-like domain superfamily,0.87158203,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9489541611036938,0.9004430660168364,0.004430660168365086,0.9,203.23,18.0,18.0,89.79066265060241,2.921620089201569e-35,APE/P+1 activation segment,True,assigned_and_evaluated +15985,43624,25.760502,0.9667969,Homedomain-like superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.9609375,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.9760848951360999,0.1594389260894531,0.007089056269384138,,22.490853511493476,6.0,19.0,27.72854817456011,1.010107063311639e-07,HTH/wHTH recognition-helix N-cap detector,True,assigned_and_evaluated +15986,25167,16.569635,0.69921875,cell outer membrane,go_cc,25167,cell outer membrane,0.69921875,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9143652561247217,0.6614621301096711,0.005316792202038104,0.75,124.41000230479398,20.0,20.0,136.43249427917618,1.5446348002941576e-42,Outer membrane beta-barrel strands,True,assigned_and_evaluated +15987,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mur ligase pre-ATP helix,False,no_term_above_threshold +15988,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural small-polar patches,False,no_term_above_threshold +15989,87277,16.946806,0.69677734,Cell outer membrane,keyword,88058,Signal,0.6220703,133,keywords,Cell outer membrane,keyword:keywords:Cell outer membrane,7.0,2257.0,0.8438730158730159,0.4493141518902643,0.0031014621178555605,0.42857142857142855,144.87172011661806,2.0,20.0,14.64889434889435,0.013913486621756137,Post-signal peptide propeptides,True,assigned_and_evaluated +15990,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclease C-terminal binding helices,False,no_term_above_threshold +15991,38317,16.24514,0.7792969,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7792969,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7686349206349207,0.04470057645261663,0.0031014621178555605,,14.41274300765082,0.0,17.0,0.0,1.0,Core-peaked broad IDR activation,True,assigned_and_evaluated +15992,45289,18.198643,0.99560547,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.99560547,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,18.0,18.0,903.3484848484848,1.5346281021350595e-52,Amphipathic active-site rim helix,True,assigned_too_few_test_positives +15993,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved structured domain cores,False,no_term_above_threshold +15994,64620,17.021997,0.98339844,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.98339844,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,18.0,18.0,324.0271739130435,5.533327411098764e-45,Histidine kinase CA-domain motifs,True,assigned_too_few_test_positives +15995,38873,18.560131,0.8642578,AAA+ ATPase domain,interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.68408203,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9949378330373001,0.6705747126436782,0.002215330084182543,0.8,302.69742528735634,12.0,12.0,171.32471264367817,4.232415391986194e-27,ABC NBD Q-loop region,True,assigned_and_evaluated +15996,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GAF/PAS/H-NOX sensory core,False,no_term_above_threshold +15997,-1,,,,,-1,,,0,,,,,,,,,,,,,,,DNA contact interface segments,False,no_term_above_threshold +15998,63951,19.778685,0.9980469,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.87597656,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9992091735863978,0.7966200466200468,0.003987594151528578,1.0,199.77460502460508,13.0,13.0,161.13783783783785,5.855500824189145e-29,Ig-like domain disulfide motif,True,assigned_and_evaluated +15999,88009,19.374931,0.60058594,Repeat,keyword,88009,Repeat,0.60058594,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.6184173726591542,0.15256215377797322,0.07266282676118742,0.006097560975609756,2.099590128517595,11.0,17.0,5.736549311174284,4.691062098338684e-07,Acidic glycine-rich disordered repeats,True,assigned_and_evaluated +16000,27932,38.68935,0.94140625,structural constituent of ribosome,go_mf,88022,Ribosomal protein,0.90185547,200,go,GO:0003735,go_mf:go:GO:0003735,44.0,2257.0,0.9986751838310808,0.9473504646560817,0.01949490474080638,1.0,48.59477269838129,13.0,14.0,96.11520337301587,2.37175854731378e-25,Ribosome-associated RNA-binding proteins,True,assigned_and_evaluated +16001,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Transmembrane helix entry motifs,False,no_term_above_threshold +16002,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic alpha-helical regions,False,no_term_above_threshold +16003,82029,18.88445,0.95458984,MFS general substrate transporter like domains,gene3d,88161,Transmembrane helix,0.76220703,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane helix boundary signature,True,assigned_too_few_test_positives +16004,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lipoxygenase catalytic domain activation,False,no_term_above_threshold +16005,87326,16.43823,0.6064453,Coiled coil,keyword,87326,Coiled coil,0.6064453,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6607446411542767,0.13503782735651637,0.03943287549844927,0.0449438202247191,3.424498610602893,12.0,18.0,8.40501867907239,1.4878219757400116e-09,Soluble amphipathic coiled-coils,True,assigned_and_evaluated +16006,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NlpC/P60 active-site loop,False,no_term_above_threshold +16007,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTM-dense low-complexity coiled-coil scaffolds,False,no_term_above_threshold +16008,37468,15.966818,0.75341797,"Zinc finger, RING-type",interpro,46929,"Zinc finger, RING/FYVE/PHD-type",0.7402344,99,ip,IPR001841,interpro:ip:IPR001841,,,,,,,,12.0,14.0,117.75049374588544,5.0267741023558664e-24,C-terminal acidic S/T/P-rich IDRs,True,assigned_too_few_test_positives +16009,47529,19.887934,0.9267578,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.9267578,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.9728357875948237,0.4525124229223927,0.007089056269384138,0.375,63.83253365849002,5.0,14.0,27.617657958124887,1.2514327720501285e-06,Extracytoplasmic β-sandwich CuA/Ig strands,True,assigned_and_evaluated +16010,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical scaffold near active site,False,no_term_above_threshold +16011,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic coiled-coil signaling stalks,False,no_term_above_threshold +16012,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SSB-like acidic IDR tails,False,no_term_above_threshold +16013,37640,25.220432,0.98339844,EF-hand domain,interpro,46081,EF-hand domain pair,0.97753906,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,20.0,0.0,1.0,Glycine-anchored acidic Ca2+ loops,True,assigned_too_few_test_positives +16014,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide phosphate-binding architecture,False,no_term_above_threshold +16015,38317,29.748388,1.0,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,1.0,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,1.0,0.9999999999999998,0.0031014621178555605,1.0,322.42857142857133,19.0,19.0,384.6516129032258,1.3780509289732512e-48,PPR repeat-start detector,True,assigned_and_evaluated +16016,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM extracytoplasmic activation,False,no_term_above_threshold +16017,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polymerase palm and coiled-coil,False,no_term_above_threshold +16018,85762,29.81934,0.9824219,FAD/NAD(P)-binding domain,gene3d,63960,FAD/NAD(P)-binding domain superfamily,0.9770508,65,gene3d,3.50.50.60,gene3d:gene3d:3.50.50.60,,,,,,,,12.0,12.0,205.58965517241379,4.745472356953812e-28,Internal Rossmann beta-strands,True,assigned_too_few_test_positives +16019,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal transit peptide detector,False,no_term_above_threshold +16020,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Lumenal NAT8 acetyltransferase domain,False,no_term_above_threshold +16021,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Multipass membrane protein cytosolic domains,False,no_term_above_threshold +16022,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic beta-rich ectodomains,False,no_term_above_threshold +16023,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted and virion surface binder,False,no_term_above_threshold +16024,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tubulin/FtsZ GTPase core,False,no_term_above_threshold +16025,63831,15.661206,0.90722656,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.90722656,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9024877832074634,0.015074073831566016,0.002658396101019052,,5.670364106307416,0.0,12.0,0.0,1.0,Helix N-cap signal,True,assigned_and_evaluated +16026,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Solvent-exposed caps and linkers,False,no_term_above_threshold +16027,50763,19.757692,0.9790039,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.96972656,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,1.0,18.0,16.89937641723356,0.09457500254505252,Low-complexity RING E3 flanks,True,assigned_too_few_test_positives +16028,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PG/charged juxtamembrane linkers,False,no_term_above_threshold +16029,82107,17.520296,0.8876953,1.20.1280.50,gene3d,63831,F-box-like domain superfamily,0.88183594,81,gene3d,1.20.1280.50,gene3d:gene3d:1.20.1280.50,,,,,,,,0.0,16.0,0.0,1.0,Short phosphate/ester catalytic motifs,True,assigned_too_few_test_positives +16030,46079,36.254097,0.98291016,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.98291016,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.9963663787193199,0.5881463290614484,0.0057598582188746125,0.8461538461538461,102.11125113012992,14.0,14.0,93.1578125,7.9195598421707925e-28,Solenoid repeat N-cap turns,True,assigned_and_evaluated +16031,87697,20.66151,0.7993164,Knottin,keyword,87697,Knottin,0.7993164,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.824165915238954,0.08263715542589735,0.017279574656623838,,4.782360507596162,0.0,19.0,0.0,1.0,Surface-exposed interaction patches,True,assigned_and_evaluated +16032,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PheRS beta RTExxxR motif,False,no_term_above_threshold +16033,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Bulky hydrophobic packing anchors,False,no_term_above_threshold +16034,82029,18.045837,0.74658203,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.7368164,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,0.0,17.0,0.0,1.0,Transporter interfacial gating helices,True,assigned_too_few_test_positives +16035,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic loop hydrophobic motifs,False,no_term_above_threshold +16036,25169,20.807388,0.8671875,pilus,go_cc,25169,pilus,0.8671875,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.9980017761989343,0.4074786324786325,0.002215330084182543,0.2,183.93585470085472,1.0,16.0,34.50289351851852,0.04769315491941616,Beta-sandwich strand runs,True,assigned_and_evaluated +16037,85649,35.884327,0.97998047,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9736328,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.97139075940991,0.7912112852038866,0.0101905183872397,0.7391304347826086,77.64190742196399,18.0,18.0,110.61410018552876,7.381758732295342e-37,C-terminal Lys/Pro activation segment,True,assigned_and_evaluated +16038,-1,,,,,-1,,,0,,,,,,,,,,,,,,,HK CA-domain ATP-binding motifs,False,no_term_above_threshold +16039,88158,18.52222,0.66552734,Translocation,keyword,88158,Translocation,0.66552734,68,keywords,Translocation,keyword:keywords:Translocation,18.0,2257.0,0.4966502903081733,0.007975188303057155,0.007975188303057155,,1.0,0.0,10.0,0.0,1.0,Chemoreceptor cytosolic coiled-coils,True,assigned_and_evaluated +16040,45289,21.34739,0.9946289,Dimeric alpha-beta barrel,interpro,45289,Dimeric alpha-beta barrel,0.9946289,28,ip,IPR011008,interpro:ip:IPR011008,,,,,,,,16.0,17.0,850.2103386809268,3.4125728124381696e-46,α/β barrel β-loop activation,True,assigned_too_few_test_positives +16041,-1,,,,,-1,,,0,,,,,,,,,,,,,,,L27-like helical interaction modules,False,no_term_above_threshold +16042,36091,25.60103,1.0,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9916992,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,15.0,15.0,377.3481012658228,8.377022726305081e-39,GNAT Motif A acetyl‑CoA loop‑helix,True,assigned_too_few_test_positives +16043,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cofactor-anchoring active-site loops,False,no_term_above_threshold +16044,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helicase ATPase cores,False,no_term_above_threshold +16045,36977,18.504925,0.98779297,"Serine-threonine/tyrosine-protein kinase, catalytic domain",interpro,81685,Transferase(Phosphotransferase) domain 1,0.9370117,30,ip,IPR001245,interpro:ip:IPR001245,,,,,,,,0.0,12.0,0.0,1.0,DFG-to-APE activation segment,True,assigned_too_few_test_positives +16046,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical enzyme scaffolds,False,no_term_above_threshold +16047,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered SH2-adjacent regulatory linkers,False,no_term_above_threshold +16048,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-cytosolic acidic accessory domains,False,no_term_above_threshold +16049,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal disorder-to-order patch,False,no_term_above_threshold +16050,64620,17.979712,0.9160156,Histidine kinase/HSP90-like ATPase superfamily,interpro,64620,Histidine kinase/HSP90-like ATPase superfamily,0.9160156,31,ip,IPR036890,interpro:ip:IPR036890,,,,,,,,16.0,17.0,304.9667519181586,4.501986146074166e-39,GHKL ATPase core module,True,assigned_too_few_test_positives +16051,81858,16.185583,0.9321289,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7080078,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,15.0,0.0,1.0,Pore-lining/interface TM helices,True,assigned_too_few_test_positives +16052,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FG/GY-rich disordered repeats,False,no_term_above_threshold +16053,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +16054,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-TM cytosolic N-tail,False,no_term_above_threshold +16055,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic assembly scaffold domains,False,no_term_above_threshold +16056,36886,21.027655,0.95166016,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.95166016,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.8719986660738106,0.5922551796527207,0.003544528134692069,0.75,167.08999255952384,18.0,18.0,233.80784313725488,1.5159322438572416e-42,Fungal Zn2Cys6 middle homology region,True,assigned_and_evaluated +16057,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal capsid interfacial strands,False,no_term_above_threshold +16058,85664,22.54027,0.9692383,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9692383,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,17.0,18.0,312.8262345679012,1.2658089856290458e-41,Conserved GT-B N-terminal motif,True,assigned_too_few_test_positives +16059,85682,15.622964,0.82666016,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.7939453,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9604749103942652,0.1369906797504095,0.011076650420912717,,12.367518567866968,3.0,18.0,17.044311034877072,0.00120250395631862,Short amphipathic interface helices,True,assigned_and_evaluated +16060,36091,18.677866,0.9980469,GNAT domain,interpro,49230,Acyl-CoA N-acyltransferase,0.9873047,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,11.0,0.0,1.0,PDZ GLGF carboxylate-binding loop,True,assigned_too_few_test_positives +16061,59224,28.135094,0.9770508,Alpha/Beta hydrolase fold,interpro,59224,Alpha/Beta hydrolase fold,0.9770508,119,ip,IPR029058,interpro:ip:IPR029058,7.0,2257.0,0.9917460317460317,0.167790594498669,0.0031014621178555605,,54.10048168335656,0.0,8.0,0.0,1.0,Active-site pre-Tyr helix,True,assigned_and_evaluated +16062,59229,18.981153,0.93115234,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8378906,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9420906153906037,0.16792984676892947,0.0101905183872397,,16.479028876411903,6.0,11.0,57.96888672824501,6.23931639505932e-10,Noncatalytic scaffold α-helices,True,assigned_and_evaluated +16063,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity charged Gly/Ser IDRs,False,no_term_above_threshold +16064,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal PLP-adjacent conserved segment,False,no_term_above_threshold +16065,47717,20.867348,1.0,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6142578,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,13.0,15.0,237.02538226299694,5.697816754768172e-30,Conserved helicase motor core,True,assigned_too_few_test_positives +16066,85364,19.619066,0.99560547,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.99560547,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,18.0,19.0,285.26794258373207,3.1547558860986923e-43,VFT two-loop ligand clamp,True,assigned_too_few_test_positives +16067,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM2-HAMP juxtamembrane helices,False,no_term_above_threshold +16068,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic accessory metallopeptidase tracts,False,no_term_above_threshold +16069,59229,23.4444,0.9633789,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9633789,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9863181658946714,0.5969001729568836,0.0101905183872397,0.782608695652174,58.57407349407331,0.0,16.0,0.0,1.0,REC switch-region motif,True,assigned_and_evaluated +16070,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Surface helical hairpin hinge,False,no_term_above_threshold +16071,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Folded mid-sequence regions,False,no_term_above_threshold +16072,87326,36.538994,0.7651367,Coiled coil,keyword,87326,Coiled coil,0.7651367,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.7873616236162362,0.4129268012531014,0.03943287549844927,0.47191011235955055,10.471638094699436,16.0,19.0,10.616865699880913,4.307920495700391e-15,Extended coiled-coil scaffolds,True,assigned_and_evaluated +16073,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PEST-like Pro/Ser-rich IDRs,False,no_term_above_threshold +16074,85682,15.981361,0.8129883,NAD(P)-binding Rossmann-like Domain,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.76220703,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9710483870967741,0.17121578674060506,0.011076650420912717,,15.457361226941824,0.0,16.0,0.0,1.0,Active-site catalytic loop motif,True,assigned_and_evaluated +16075,48767,16.224478,0.9975586,DNA-binding pseudobarrel domain superfamily,interpro,46277,"Nucleic acid-binding, OB-fold",0.93359375,38,ip,IPR015300,interpro:ip:IPR015300,,,,,,,,3.0,17.0,164.39613970588235,1.5280314702172432e-06,Charged β-edge cap motif,True,assigned_too_few_test_positives +16076,87489,15.952184,0.8618164,GPI-anchor,keyword,87522,Glycoprotein,0.79785156,88,keywords,GPI-anchor,keyword:keywords:GPI-anchor,7.0,2257.0,0.8086666666666666,0.06850202212757547,0.0031014621178555605,,22.08700913456255,3.0,20.0,22.08185185185185,0.0005820446848073517,N-glycosylation sequon detector,True,assigned_and_evaluated +16077,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic extracytoplasmic loops,False,no_term_above_threshold +16078,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate beta-propeller catalytic domains,False,no_term_above_threshold +16079,45324,23.453781,0.9667969,Pectin lyase fold/virulence factor,interpro,45324,Pectin lyase fold/virulence factor,0.9667969,34,ip,IPR011050,interpro:ip:IPR011050,5.0,2257.0,0.9985790408525755,0.4969230769230769,0.002215330084182543,0.8,224.31107692307694,18.0,18.0,546.9816513761467,7.774077354345683e-49,Extracellular β-solenoid glycan-binding caps,True,assigned_and_evaluated +16080,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RNAP β'/β core architecture,False,no_term_above_threshold +16081,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal PLP-binding segment,False,no_term_above_threshold +16082,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mid-chain β-sandwich substrate strip,False,no_term_above_threshold +16083,31094,15.689039,0.92626953,phosphopantetheine binding,go_mf,31094,phosphopantetheine binding,0.92626953,31,go,GO:0031177,go_mf:go:GO:0031177,10.0,2257.0,0.8837561192701381,0.07962460212506703,0.004430660168365086,,17.97127269962763,0.0,16.0,0.0,1.0,C-terminal TM and loop activation,True,assigned_and_evaluated +16084,12207,16.076271,0.9770508,transposition,go_bp,88163,Transposable element,0.8613281,30,go,GO:0032196,go_bp:go:GO:0032196,,,,,,,,3.0,16.0,243.02038043478262,4.6619020678915415e-07,"Retroelements, transposases, domesticated proteins",True,assigned_too_few_test_positives +16085,85664,16.10925,0.81152344,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.81152344,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,7.0,19.0,122.0312865497076,2.2305936950933658e-13,C-terminal regulatory linkers,True,assigned_too_few_test_positives +16086,29104,21.774113,0.7758789,NADH dehydrogenase (ubiquinone) activity,go_mf,6543,NADH:ubiquinone reductase (H+-translocating),0.7685547,45,go,GO:0008137,go_mf:go:GO:0008137,,,,,,,,11.0,11.0,428.9280575539568,2.68532943002915e-29,Energy-transducing multi-pass membrane proteins,True,assigned_too_few_test_positives +16087,36535,21.88618,0.9589844,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.9580078,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9486648865153537,0.7575462406200111,0.004430660168365086,0.9,170.9781865079365,12.0,12.0,89.79066265060241,9.608590434204234e-24,Kinase C-lobe activation loop,True,assigned_and_evaluated +16088,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered mixed-charge linker patches,False,no_term_above_threshold +16089,59229,44.575665,0.9628906,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9628906,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8863415203767856,0.7330246488270238,0.0101905183872397,0.7391304347826086,71.9320274957649,18.0,18.0,106.27629233511585,1.4850343564104726e-36,N-terminal extensions in SAM transferases,True,assigned_and_evaluated +16090,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Proline-rich disordered tails,False,no_term_above_threshold +16091,36010,17.81558,0.9848633,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.97558594,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,0.0,15.0,0.0,1.0,Hydrolase N-cap VxxP motif,True,assigned_too_few_test_positives +16092,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Luminal amphipathic alpha helices,False,no_term_above_threshold +16093,30107,16.280834,0.7993164,nickel cation binding,go_mf,30107,nickel cation binding,0.7993164,31,go,GO:0016151,go_mf:go:GO:0016151,20.0,2257.0,0.9721054984354046,0.5472485475337192,0.008861320336730172,0.95,61.75699858918022,0.0,14.0,0.0,1.0,Ntn-hydrolase beta-strand hotspot,True,assigned_and_evaluated +16094,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Carbohydrate-active enzyme active site,False,no_term_above_threshold +16095,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic TM hairpin,False,no_term_above_threshold +16096,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal membrane-anchoring helices,False,no_term_above_threshold +16097,85682,16.396019,0.63427734,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.63427734,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.6745698924731183,0.26602665889664195,0.011076650420912717,0.28,24.016886765188836,1.0,12.0,8.522155517438536,0.17952300004245264,Extracellular VFT/PBP hinge helices,True,assigned_and_evaluated +16098,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered charged regulatory tails,False,no_term_above_threshold +16099,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane β-barrel hairpins,False,no_term_above_threshold +16100,72011,16.713562,0.9790039,"AMP-binding enzyme, C-terminal domain superfamily",interpro,81685,Transferase(Phosphotransferase) domain 1,0.8847656,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,16.0,16.0,590.3069306930694,2.3930561419192917e-44,Helix/strand capping micromotifs,True,assigned_too_few_test_positives +16101,36886,28.920366,0.9819336,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.9819336,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.9363328145842597,0.7955819549057254,0.003544528134692069,0.875,224.45355902777777,13.0,19.0,159.97378740970072,1.0050188741250633e-26,Non-DBD transcriptional regulatory IDRs,True,assigned_and_evaluated +16102,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity disordered tails,False,no_term_above_threshold +16103,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical cores and transmembrane helices,False,no_term_above_threshold +16104,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycan-cleaving CAZyme catalytic domains,False,no_term_above_threshold +16105,45290,15.613509,0.8701172,Protein kinase-like domain superfamily,interpro,45290,Protein kinase-like domain superfamily,0.8701172,153,ip,IPR011009,interpro:ip:IPR011009,13.0,2257.0,0.9380399012751955,0.06794072290462656,0.0057598582188746125,,11.795554738134012,0.0,14.0,0.0,1.0,Helical hydrophobic/basic motif,True,assigned_and_evaluated +16106,88161,52.225266,0.65722656,Transmembrane helix,keyword,88161,Transmembrane helix,0.65722656,4197,keywords,Transmembrane helix,keyword:keywords:Transmembrane helix,417.0,2257.0,0.7060473360442081,0.5087601997441523,0.1847585290208241,0.49640287769784175,2.7536493305097167,11.0,11.0,5.4274920345926265,1.6633903518332707e-08,Juxtamembrane helix anchor motif,True,assigned_and_evaluated +16107,36886,16.388826,0.7519531,Zn(2)Cys(6) fungal-type DNA-binding domain,interpro,36886,Zn(2)Cys(6) fungal-type DNA-binding domain,0.7519531,75,ip,IPR001138,interpro:ip:IPR001138,8.0,2257.0,0.6087705646954202,0.009875377233094524,0.003544528134692069,,2.7860908018867927,0.0,20.0,0.0,1.0,SLH alpha-helical surface patches,True,assigned_and_evaluated +16108,82029,33.660854,0.9848633,MFS general substrate transporter like domains,gene3d,64026,MFS transporter superfamily,0.9682617,113,gene3d,1.20.1250.20,gene3d:gene3d:1.20.1250.20,,,,,,,,19.0,19.0,188.0788643533123,4.960484987757626e-43,Amphipathic pre-TM cytosolic helix,True,assigned_too_few_test_positives +16109,88058,17.842667,0.6064453,Signal,keyword,88058,Signal,0.6064453,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.6116859878912961,0.10607397509591425,0.09127159946832078,,1.1621794261722256,2.0,20.0,0.7204954682779456,1.0,Lys/Arg-rich targeting and processing motifs,True,assigned_and_evaluated +16110,87697,15.925186,0.84765625,Knottin,keyword,88058,Signal,0.80566406,177,keywords,Knottin,keyword:keywords:Knottin,39.0,2257.0,0.9584402672770572,0.16497990819783712,0.017279574656623838,,9.547683405192778,0.0,15.0,0.0,1.0,Bacterial protein C-terminal tail,True,assigned_and_evaluated +16111,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic juxtamembrane Pro/acidic linkers,False,no_term_above_threshold +16112,69819,18.364119,0.9267578,"ATPase, nucleotide binding domain",interpro,84753,3.30.420.40,0.8989258,35,ip,IPR043129,interpro:ip:IPR043129,,,,,,,,17.0,17.0,419.86619718309856,1.776833158726609e-44,Eukaryotic pantothenate kinase C-terminal motif,True,assigned_too_few_test_positives +16113,85664,21.326086,0.85791016,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.85791016,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,8.0,16.0,165.61388888888888,1.7865204112757912e-16,Nucleotide-sugar transferase catalytic core,True,assigned_too_few_test_positives +16114,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory luminal glycosyltransferases,False,no_term_above_threshold +16115,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered small/polar segments,False,no_term_above_threshold +16116,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extended alpha-helical regions,False,no_term_above_threshold +16117,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix N-cap specificity loop,False,no_term_above_threshold +16118,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled-coils and pre-transmembrane helices,False,no_term_above_threshold +16119,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic structural connectors,False,no_term_above_threshold +16120,81858,17.560787,0.8691406,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.6376953,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,14.0,0.0,1.0,Transmembrane helix exit signature,True,assigned_too_few_test_positives +16121,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extramembrane ion channel regulatory domains,False,no_term_above_threshold +16122,59229,17.635283,0.6713867,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.6713867,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.5791035771281771,0.09143189455859783,0.0101905183872397,0.08695652173913043,8.972251566032838,11.0,16.0,73.06495098039215,4.928682198305127e-19,Class I SAM MTase core,True,assigned_and_evaluated +16123,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mature extracytoplasmic domains,False,no_term_above_threshold +16124,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic transmembrane alpha-helices,False,no_term_above_threshold +16125,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase CA signature,False,no_term_above_threshold +16126,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal hydrophobic LxPxL motif,False,no_term_above_threshold +16127,64148,34.647564,0.9194336,Winged helix DNA-binding domain superfamily,interpro,64146,Winged helix-like DNA-binding domain superfamily,0.88916016,195,ip,IPR036390,interpro:ip:IPR036390,19.0,2257.0,0.9932740698932317,0.7559818925268841,0.008418254319893664,0.631578947368421,89.80269112806197,11.0,19.0,51.518538884524745,5.637256102475075e-17,Disorder-to-helix docking helices,True,assigned_and_evaluated +16128,55053,15.831813,0.7753906,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.7753906,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,17.0,0.0,1.0,ABC transporter transmembrane helix signal,True,assigned_too_few_test_positives +16129,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short hydrophobic junction motif,False,no_term_above_threshold +16130,87914,16.081308,0.65625,Phosphoprotein,keyword,24917,nucleus,0.63623047,957,keywords,Phosphoprotein,keyword:keywords:Phosphoprotein,84.0,2257.0,0.7952112506300264,0.16934706936871746,0.03721754541426672,0.011904761904761904,4.550194471014231,8.0,20.0,2.4372406745017887,0.017471573064792374,Ser/Thr-rich disordered regulatory regions,True,assigned_and_evaluated +16131,88153,17.107534,0.6508789,Transferase,keyword,88153,Transferase,0.6508789,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.743371249341645,0.18663917455141243,0.052724856003544526,0.09243697478991597,3.539870730777629,6.0,18.0,3.7818585474151596,0.005904263346412955,Internal helix packing segments,True,assigned_and_evaluated +16132,35372,17.439766,0.98828125,ABC-type transporter activity,go_mf,81858,Rhodopsin 7-helix transmembrane proteins,0.7651367,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,0.0,17.0,0.0,1.0,Transmembrane helix boundaries and kinks,True,assigned_too_few_test_positives +16133,72011,15.884292,0.9692383,"AMP-binding enzyme, C-terminal domain superfamily",interpro,85656,alpha/beta hydrolase,0.8300781,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,0.0,15.0,0.0,1.0,Glycosyltransferase PVYNE helix-start motif,True,assigned_too_few_test_positives +16134,36091,18.025366,0.9370117,GNAT domain,interpro,64058,NAD(P)-binding domain superfamily,0.9301758,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,15.0,0.0,1.0,SAM-binding MTase residues,True,assigned_too_few_test_positives +16135,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic envelope remodeling machinery,False,no_term_above_threshold +16136,63951,15.8887,0.7416992,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.67871094,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.7141903914590747,0.11070766079873548,0.003987594151528578,,27.76302115808289,0.0,16.0,0.0,1.0,IPT/TIG β-sandwich domains,True,assigned_and_evaluated +16137,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad C-terminal catalytic-membrane activation,False,no_term_above_threshold +16138,36104,32.80921,1.0,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,1.0,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,16.0,0.0,1.0,Mobile inter-subunit coupling loops,True,assigned_too_few_test_positives +16139,25014,17.224897,0.8046875,endoplasmic reticulum membrane,go_cc,88161,Transmembrane helix,0.71777344,161,go,GO:0005789,go_cc:go:GO:0005789,35.0,2257.0,0.7778449273498779,0.06078345208425355,0.015507310589277802,,3.9196643244045792,2.0,15.0,4.9131437989287186,0.10022036896103033,Cytosolic juxtamembrane anchor motif,True,assigned_and_evaluated +16140,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic catalytic loop hotspot,False,no_term_above_threshold +16141,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Basic N-terminal amphipathic segments,False,no_term_above_threshold +16142,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal trafficking/sorting signals,False,no_term_above_threshold +16143,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic metal-binding nucleic-acid motif,False,no_term_above_threshold +16144,35372,22.873697,0.97265625,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.97265625,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,6.0,17.0,247.5612456747405,1.9290551316112715e-13,Inter-TM coupling helices,True,assigned_too_few_test_positives +16145,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic low-complexity IDRs,False,no_term_above_threshold +16146,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Acidic serine-rich IDRs,False,no_term_above_threshold +16147,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ligand-contacting Gly/Pro boundary loops,False,no_term_above_threshold +16148,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS-domain coupling elements,False,no_term_above_threshold +16149,47717,20.854578,0.9995117,"Helicase superfamily 1/2, ATP-binding domain",interpro,85672,P-loop containing nucleotide triphosphate hydrolases,0.63964844,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,15.0,15.0,273.49082568807336,1.0182413404848812e-36,Helicase motif II-III coupling,True,assigned_too_few_test_positives +16150,38317,18.598492,0.78222656,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.78222656,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.6540952380952382,0.006597825872504295,0.0031014621178555605,,2.127327570606028,0.0,11.0,0.0,1.0,N-terminal leader and secondary structure,True,assigned_and_evaluated +16151,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding recognition lobe,False,no_term_above_threshold +16152,87852,16.991367,0.8232422,Nucleosome core,keyword,87852,Nucleosome core,0.8232422,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,15.0,0.0,1.0,Glycine-rich RGG/GAR IDRs,True,assigned_too_few_test_positives +16153,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Interface packing helices/strands,False,no_term_above_threshold +16154,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PAS/LOV transition motifs,False,no_term_above_threshold +16155,87326,33.409794,0.67578125,Coiled coil,keyword,87326,Coiled coil,0.67578125,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6678293046975413,0.28619385250572926,0.03943287549844927,0.25842696629213485,7.25774747309473,16.0,16.0,12.607528018608585,5.942502901527074e-18,Phospho-regulated disordered coiled-coil linkers,True,assigned_and_evaluated +16156,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ADP-ribose/NMP-binding motifs,False,no_term_above_threshold +16157,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich catalytic gating tracts,False,no_term_above_threshold +16158,87326,20.591772,0.6538086,Coiled coil,keyword,87326,Coiled coil,0.6538086,1122,keywords,Coiled coil,keyword:keywords:Coiled coil,89.0,2257.0,0.6964607778100252,0.11897950991534298,0.03943287549844927,,3.0172668975160577,7.0,18.0,4.902927562792228,0.0005121872646802977,Cytosolic amphipathic helical scaffolds,True,assigned_and_evaluated +16159,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SF1 helicase post-P-loop ssDNA track,False,no_term_above_threshold +16160,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved ASL helical motifs,False,no_term_above_threshold +16161,55053,15.754382,0.9736328,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,0.9736328,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,12.0,16.0,414.03472222222223,4.563865098854154e-30,Diffuse whole-protein activation,True,assigned_too_few_test_positives +16162,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ABC NBD A-loop motif,False,no_term_above_threshold +16163,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane entry TM1-TM2 hairpin,False,no_term_above_threshold +16164,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nuclear low-complexity regulatory IDRs,False,no_term_above_threshold +16165,85672,23.919666,0.6142578,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.61035156,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6614763119715843,0.21026397685056064,0.01595037660611431,0.16666666666666666,13.182383215325428,13.0,14.0,37.15594439117929,5.005580378424267e-20,C-terminal substrate-engaging lids,True,assigned_and_evaluated +16166,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cytosolic domains of membrane proteins,False,no_term_above_threshold +16167,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Noncatalytic accessory domain edges,False,no_term_above_threshold +16168,36354,19.354559,0.9501953,RNA recognition motif domain,interpro,63774,RNA-binding domain superfamily,0.9296875,60,ip,IPR000504,interpro:ip:IPR000504,,,,,,,,0.0,19.0,0.0,1.0,Two-component core helices,True,assigned_too_few_test_positives +16169,36409,17.944908,0.90966797,"Zinc finger, CCCH-type",interpro,36409,"Zinc finger, CCCH-type",0.90966797,43,ip,IPR000571,interpro:ip:IPR000571,,,,,,,,16.0,17.0,418.7603160667252,2.902560589967525e-41,Regulatory IDRs in nuclear RBPs,True,assigned_too_few_test_positives +16170,50869,18.792637,0.98876953,"DNA binding HTH domain, AraC-type",interpro,81685,Transferase(Phosphotransferase) domain 1,0.95947266,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,0.0,12.0,0.0,1.0,Kinase helix C-cap motif,True,assigned_too_few_test_positives +16171,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal helical substrate-recognition module,False,no_term_above_threshold +16172,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphodiesterase catalytic core,False,no_term_above_threshold +16173,85672,27.906017,0.6459961,P-loop containing nucleotide triphosphate hydrolases,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.6381836,408,gene3d,3.40.50.300,gene3d:gene3d:3.40.50.300,36.0,2257.0,0.6771974586022312,0.25607439274333627,0.01595037660611431,0.3333333333333333,16.054441789491943,15.0,20.0,30.010570469798658,3.116533736045915e-20,Noncanonical helical activation motif,True,assigned_and_evaluated +16174,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal beta-rich secretory domain,False,no_term_above_threshold +16175,85682,16.98289,0.6274414,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.6274414,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.6718458781362007,0.0650748136458587,0.011076650420912717,,5.8749541759481225,0.0,11.0,0.0,1.0,Basic tRNA-binding patch,True,assigned_and_evaluated +16176,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-centric structured domain feature,False,no_term_above_threshold +16177,28622,16.903734,0.8598633,transposase activity,go_mf,88163,Transposable element,0.6816406,31,go,GO:0004803,go_mf:go:GO:0004803,5.0,2257.0,0.7982238010657194,0.38421946536700635,0.002215330084182543,0.6,173.43666666666667,3.0,16.0,214.9795673076923,6.75799162928635e-07,Broad nucleic-acid binding regions,True,assigned_and_evaluated +16178,38890,21.237865,0.8666992,HNH nuclease,interpro,36499,"Zinc finger, GATA-type",0.8105469,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,4.0,14.0,370.3167701863354,6.412701582571828e-10,Helix–coil boundary hinge motifs,True,assigned_too_few_test_positives +16179,63960,27.589539,0.9301758,FAD/NAD(P)-binding domain superfamily,interpro,63960,FAD/NAD(P)-binding domain superfamily,0.9301758,72,ip,IPR036188,interpro:ip:IPR036188,,,,,,,,15.0,15.0,193.57467532467533,1.7387176222033654e-34,Substrate-channel gating helix,True,assigned_too_few_test_positives +16180,32555,15.863028,0.85009766,"proton-transporting ATP synthase activity, rotational mechanism",go_mf,87598,Hydrogen ion transport,0.75,70,go,GO:0046933,go_mf:go:GO:0046933,23.0,2257.0,0.9698435249698337,0.3607906083376791,0.0101905183872397,0.043478260869565216,35.404539261658336,10.0,18.0,199.53480589022757,2.4616349712534938e-21,N-terminal amphipathic leader,True,assigned_and_evaluated +16181,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic anion-binding loop,False,no_term_above_threshold +16182,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TM-to-cytosol interface hotspots,False,no_term_above_threshold +16183,38317,20.667713,0.7788086,Pentatricopeptide repeat,interpro,38317,Pentatricopeptide repeat,0.7788086,85,ip,IPR002885,interpro:ip:IPR002885,7.0,2257.0,0.7082539682539682,0.050098937394019355,0.0031014621178555605,,16.153328814043096,0.0,11.0,0.0,1.0,Active-site cavity-forming cores,True,assigned_and_evaluated +16184,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sensory-domain output helix,False,no_term_above_threshold +16185,50338,19.477438,0.99902344,"GPCR, rhodopsin-like, 7TM",interpro,81858,Rhodopsin 7-helix transmembrane proteins,0.9628906,27,ip,IPR017452,interpro:ip:IPR017452,,,,,,,,17.0,17.0,392.24342105263156,5.553476033233558e-44,GPCR TM2–ECL1–TM3 disulfide module,True,assigned_too_few_test_positives +16186,64058,16.596437,0.87353516,NAD(P)-binding domain superfamily,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8125,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.970065600917139,0.24298738965058084,0.006202924235711121,,39.17303846009721,5.0,12.0,47.49920331421287,7.607673371273721e-08,Conserved noncatalytic glycosyltransferase motifs,True,assigned_and_evaluated +16187,37282,16.806232,0.8564453,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.7758789,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,18.0,18.0,223.29962546816478,3.38732084218649e-42,Flanking C-terminal interaction regions,True,assigned_too_few_test_positives +16188,85364,29.9125,0.96972656,Periplasmic binding protein-like II,gene3d,85364,Periplasmic binding protein-like II,0.96972656,62,gene3d,3.40.190.10,gene3d:gene3d:3.40.190.10,,,,,,,,11.0,18.0,184.01543209876544,3.620616776438465e-23,Helix-cap hinge motif,True,assigned_too_few_test_positives +16189,36914,17.160482,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.99902344,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,17.0,19.0,658.5815464587395,1.5489397236913889e-46,Glycosyltransferase glycine-rich core motif,True,assigned_too_few_test_positives +16190,47529,17.968578,0.7910156,Immunoglobulin-like fold,interpro,88058,Signal,0.67089844,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.876784917447568,0.1220717669323034,0.007089056269384138,,17.219748622888048,1.0,17.0,4.548790722514687,0.3136141447357415,Modular cysteine-rich ectodomains,True,assigned_and_evaluated +16191,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleotide phosphate-binding loops,False,no_term_above_threshold +16192,37894,16.738953,0.9770508,Short-chain dehydrogenase/reductase SDR,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9692383,26,ip,IPR002347,interpro:ip:IPR002347,,,,,,,,0.0,17.0,0.0,1.0,Motif I X-Arg helix,True,assigned_too_few_test_positives +16193,-1,,,,,-1,,,0,,,,,,,,,,,,,,,PTP catalytic core signature,False,no_term_above_threshold +16194,-1,,,,,-1,,,0,,,,,,,,,,,,,,,2OG dioxygenase pocket activation,False,no_term_above_threshold +16195,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Propeptide–mature chain boundary,False,no_term_above_threshold +16196,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal TIM barrel scaffold,False,no_term_above_threshold +16197,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Juxtamembrane interaction regions,False,no_term_above_threshold +16198,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Isolated residue-level peaks,False,no_term_above_threshold +16199,-1,,,,,-1,,,0,,,,,,,,,,,,,,,TIR/SEFIR immune signaling domain,False,no_term_above_threshold +16200,36010,18.563261,0.99560547,Alpha/beta hydrolase fold-1,interpro,59224,Alpha/Beta hydrolase fold,0.9375,28,ip,IPR000073,interpro:ip:IPR000073,,,,,,,,16.0,19.0,429.12100764732344,1.4828928465544412e-40,ABH-fold C-terminal helix/loop,True,assigned_too_few_test_positives +16201,85649,35.559967,0.98339844,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9770508,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.9093651473278581,0.772360821546165,0.0101905183872397,0.782608695652174,75.79210322737802,14.0,14.0,110.61410018552876,7.27210921345717e-29,SAM MTase core beta-strand,True,assigned_and_evaluated +16202,-1,,,,,-1,,,0,,,,,,,,,,,,,,,VWFD/link modules and enzyme metallocores,False,no_term_above_threshold +16203,59229,26.17506,0.95410156,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.95410156,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.9294597329804212,0.1488021882068847,0.0101905183872397,,14.602023425345163,0.0,15.0,0.0,1.0,N-terminal GxD phosphate-binding turn,True,assigned_and_evaluated +16204,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic small-residue loop motif,False,no_term_above_threshold +16205,38873,18.175276,0.9790039,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.9301758,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.9985790408525754,0.676923076923077,0.002215330084182543,0.6,305.56307692307695,13.0,13.0,171.32471264367817,2.6588953672088044e-29,Walker B pre-DE residue,True,assigned_and_evaluated +16206,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phospho-regulated RNA assembly scaffolds,False,no_term_above_threshold +16207,46581,18.597948,0.76123047,Nucleotide-binding alpha-beta plait domain superfamily,interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.76123047,73,ip,IPR012677,interpro:ip:IPR012677,,,,,,,,5.0,17.0,50.97554719562244,7.203767383509442e-08,Positively charged nucleic acid-binding surfaces,True,assigned_too_few_test_positives +16208,82608,31.012093,0.99853516,Ankyrin repeat-containing domain,gene3d,64507,Ankyrin repeat-containing domain superfamily,0.9980469,127,gene3d,1.25.40.20,gene3d:gene3d:1.25.40.20,8.0,2257.0,1.0,1.0,0.003544528134692069,1.0,282.125,16.0,16.0,170.34571428571428,7.72140283526014e-36,Ankyrin-repeat helix signature,True,assigned_and_evaluated +16209,37640,18.810633,0.76953125,EF-hand domain,interpro,37640,EF-hand domain,0.76953125,57,ip,IPR002048,interpro:ip:IPR002048,,,,,,,,0.0,15.0,0.0,1.0,PAS/PAC β-strand elements,True,assigned_too_few_test_positives +16210,47529,18.313934,0.80371094,Immunoglobulin-like fold,interpro,47529,Immunoglobulin-like fold,0.80371094,157,ip,IPR013783,interpro:ip:IPR013783,16.0,2257.0,0.786702365015618,0.12427829026866363,0.007089056269384138,0.125,17.531006321023366,2.0,14.0,11.047063183249954,0.02325818103664133,PEST-like disordered regulatory tails,True,assigned_and_evaluated +16211,38890,21.803373,0.9580078,HNH nuclease,interpro,38890,HNH nuclease,0.9580078,27,ip,IPR003615,interpro:ip:IPR003615,,,,,,,,8.0,20.0,518.4434782608696,2.1644944042450656e-20,Broad activation in DNA-processing enzymes,True,assigned_too_few_test_positives +16212,49061,17.670818,0.66259766,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.66259766,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.4899057873485868,0.012405848471422242,0.012405848471422242,,1.0,4.0,13.0,30.42275800484756,1.2918239329322449e-05,Viral structural N-terminal linkers,True,assigned_and_evaluated +16213,72011,17.132288,1.0,"AMP-binding enzyme, C-terminal domain superfamily",interpro,69093,"ANL, N-terminal domain",0.9736328,32,ip,IPR045851,interpro:ip:IPR045851,,,,,,,,16.0,17.0,555.582993593477,3.3943739850444213e-43,ANL adenylation core subdomain,True,assigned_too_few_test_positives +16214,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nontransmembrane beta strands/turns,False,no_term_above_threshold +16215,36535,22.334478,0.90771484,Protein kinase domain,interpro,81685,Transferase(Phosphotransferase) domain 1,0.86572266,86,ip,IPR000719,interpro:ip:IPR000719,10.0,2257.0,0.9383177570093458,0.1530719154970374,0.004430660168365086,,34.54833132768134,0.0,12.0,0.0,1.0,ABC NBD helix N-cap,True,assigned_and_evaluated +16216,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phage tail β-strand scaffolds,False,no_term_above_threshold +16217,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-proximal low-complexity IDRs,False,no_term_above_threshold +16218,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-acidic ligand-binding clefts,False,no_term_above_threshold +16219,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M20/M28 C-terminal lid motif,False,no_term_above_threshold +16220,49061,24.71698,0.77441406,WD40/YVTN repeat-like-containing domain superfamily,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.77441406,157,ip,IPR015943,interpro:ip:IPR015943,28.0,2257.0,0.6518137537653016,0.05652620112711147,0.012405848471422242,,4.556415569424664,16.0,19.0,83.26228506589857,3.357512247864845e-29,Extracellular/lumenal ectodomain signature,True,assigned_and_evaluated +16221,-1,,,,,-1,,,0,,,,,,,,,,,,,,,FKBP PPIase core domain,False,no_term_above_threshold +16222,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Alpha-helical TM interface signature,False,no_term_above_threshold +16223,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Early helix-strand element,False,no_term_above_threshold +16224,47717,16.7765,0.9506836,"Helicase superfamily 1/2, ATP-binding domain",interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.65527344,48,ip,IPR014001,interpro:ip:IPR014001,,,,,,,,10.0,10.0,273.49082568807336,1.0378758421347324e-24,Helicase C-terminal accessory regions,True,assigned_too_few_test_positives +16225,-1,,,,,-1,,,0,,,,,,,,,,,,,,,M16 metallopeptidase clamshell fold,False,no_term_above_threshold +16226,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Enolase/IlvD catalytic-loop signature,False,no_term_above_threshold +16227,36914,16.938498,0.91064453,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.84765625,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,4.0,10.0,294.4246913580247,1.3649736869534026e-09,Glycosyltransferase catalytic aromatic motif,True,assigned_too_few_test_positives +16228,52941,16.71753,0.9663086,Major facilitator superfamily domain,interpro,88161,Transmembrane helix,0.6699219,75,ip,IPR020846,interpro:ip:IPR020846,,,,,,,,0.0,13.0,0.0,1.0,Membrane helix packing motifs,True,assigned_too_few_test_positives +16229,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical assembly interfaces,False,no_term_above_threshold +16230,25169,22.437931,0.84716797,pilus,go_cc,25169,pilus,0.84716797,41,go,GO:0009289,go_cc:go:GO:0009289,5.0,2257.0,0.8964920071047957,0.3715541771279477,0.002215330084182543,0.2,167.7195555555556,9.0,19.0,261.49561403508767,3.546064541203446e-20,N-terminal export-region detector,True,assigned_and_evaluated +16231,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged helical interface segments,False,no_term_above_threshold +16232,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RT connection RNase H signature,False,no_term_above_threshold +16233,85682,16.073433,0.8310547,NAD(P)-binding Rossmann-like Domain,gene3d,85682,NAD(P)-binding Rossmann-like Domain,0.8310547,160,gene3d,3.40.50.720,gene3d:gene3d:3.40.50.720,25.0,2257.0,0.9291487455197133,0.2816739707008269,0.011076650420912717,0.32,25.42952607487065,3.0,13.0,23.59981527906056,0.00044493255434111163,Noncatalytic alpha-helical hotspots,True,assigned_and_evaluated +16234,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Coiled coil assembly scaffolds,False,no_term_above_threshold +16235,81799,16.915216,0.92285156,1.10.8.60,gene3d,58239,P-loop containing nucleoside triphosphate hydrolase,0.8364258,29,gene3d,1.10.8.60,gene3d:gene3d:1.10.8.60,,,,,,,,3.0,10.0,173.6533980582524,1.1503116648969384e-06,AAA+ catalytic/switch belt,True,assigned_too_few_test_positives +16236,48883,25.159517,0.9633789,Pyridoxal phosphate-dependent transferase,interpro,48883,Pyridoxal phosphate-dependent transferase,0.9633789,28,ip,IPR015424,interpro:ip:IPR015424,,,,,,,,15.0,15.0,480.8145161290322,2.1729929758721714e-40,PLP AAT-fold catalytic core,True,assigned_too_few_test_positives +16237,87198,18.57004,0.75341797,Bacterial flagellum,keyword,87198,Bacterial flagellum,0.75341797,37,keywords,Bacterial flagellum,keyword:keywords:Bacterial flagellum,,,,,,,,10.0,17.0,427.69727403156384,7.9292749536536815e-25,Exposed flagellar/T3SS segments,True,assigned_too_few_test_positives +16238,84152,22.417212,0.8964844,Metal-dependent hydrolases,gene3d,84152,Metal-dependent hydrolases,0.8964844,35,gene3d,3.20.20.140,gene3d:gene3d:3.20.20.140,,,,,,,,18.0,18.0,562.4622641509434,5.407112538669923e-49,Amidohydrolase superfamily catalytic core,True,assigned_too_few_test_positives +16239,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal targeting leaders,False,no_term_above_threshold +16240,81858,18.698801,0.9013672,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.60253906,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,2.0,13.0,40.23009446693657,0.0019352381243972884,Single internal transmembrane helix,True,assigned_too_few_test_positives +16241,37020,16.061096,0.9970703,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.9814453,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,16.0,17.0,768.6833199033038,1.7917833648140597e-45,Donor-binding catalytic loop,True,assigned_too_few_test_positives +16242,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Disordered receptor cytoplasmic tails,False,no_term_above_threshold +16243,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structured-region leucine detector,False,no_term_above_threshold +16244,36272,18.60775,0.97509766,"Phosphatidylinositol 3-/4-kinase, catalytic domain",interpro,36272,"Phosphatidylinositol 3-/4-kinase, catalytic domain",0.97509766,26,ip,IPR000403,interpro:ip:IPR000403,,,,,,,,0.0,10.0,0.0,1.0,Active site helical scaffolds,True,assigned_too_few_test_positives +16245,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Type IV pilus head,False,no_term_above_threshold +16246,63951,20.46858,0.9472656,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.9067383,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9945630684064848,0.2738356958945194,0.003987594151528578,,68.67190729265893,1.0,20.0,8.056891891891892,0.18832188981813525,Extracellular low-complexity linkers,True,assigned_and_evaluated +16247,81685,16.863222,0.9458008,Transferase(Phosphotransferase) domain 1,gene3d,43624,Homedomain-like superfamily,0.81933594,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.931384558277654,0.14548430106687316,0.005316792202038104,,27.363172292327725,0.0,10.0,0.0,1.0,Hydrophobic recognition helices,True,assigned_and_evaluated +16248,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rigid central helical scaffold,False,no_term_above_threshold +16249,36115,18.138227,0.7949219,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.79003906,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,19.0,0.0,1.0,Extended alpha-helical scaffolds,True,assigned_too_few_test_positives +16250,63831,16.920628,0.91015625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.91015625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.8808677624759367,0.012834265368581751,0.002658396101019052,,4.827822822814835,0.0,15.0,0.0,1.0,N-terminal first-helix motif,True,assigned_and_evaluated +16251,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GGDEF-biased cyclic-dinucleotide detector,False,no_term_above_threshold +16252,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity flexible segments,False,no_term_above_threshold +16253,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Accessory nucleic acid-binding domains,False,no_term_above_threshold +16254,81858,15.697443,0.96191406,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.7753906,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,3.0,17.0,46.14628482972137,6.645788612630533e-05,Transmembrane alpha-helix core,True,assigned_too_few_test_positives +16255,-1,,,,,-1,,,0,,,,,,,,,,,,,,,WW-domain proline-rich IDRs,False,no_term_above_threshold +16256,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Sigma70 domain 2 helix-face,False,no_term_above_threshold +16257,52236,22.183655,0.9663086,Tetratricopeptide repeat,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.93359375,65,ip,IPR019734,interpro:ip:IPR019734,,,,,,,,14.0,19.0,164.5365661344372,3.7958279824341706e-29,TPR-like alpha-solenoid scaffolds,True,assigned_too_few_test_positives +16258,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NUDIX fold hydrolase domain,False,no_term_above_threshold +16259,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P-loop NTPase ATPase core,False,no_term_above_threshold +16260,-1,,,,,-1,,,0,,,,,,,,,,,,,,,CAZy substrate groove activation,False,no_term_above_threshold +16261,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Mg2+-coordinating phosphate-binding loops,False,no_term_above_threshold +16262,45714,16.112444,0.74609375,"Myc-type, basic helix-loop-helix (bHLH) domain",interpro,45714,"Myc-type, basic helix-loop-helix (bHLH) domain",0.74609375,39,ip,IPR011598,interpro:ip:IPR011598,,,,,,,,0.0,18.0,0.0,1.0,Histidine kinase DHp/CA active-site helix,True,assigned_too_few_test_positives +16263,46078,20.49931,0.87060547,Armadillo-like helical,interpro,49116,Armadillo-type fold,0.83984375,110,ip,IPR011989,interpro:ip:IPR011989,,,,,,,,5.0,19.0,34.40731763619575,5.307653551425395e-07,HEAT activation in acidic linkers,True,assigned_too_few_test_positives +16264,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved N-terminal interface loops,False,no_term_above_threshold +16265,-1,,,,,-1,,,0,,,,,,,,,,,,,,,S/T-rich low-complexity regions,False,no_term_above_threshold +16266,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracytoplasmic β-rich soluble domains,False,no_term_above_threshold +16267,63951,18.448305,0.9370117,Immunoglobulin-like domain superfamily,interpro,47529,Immunoglobulin-like fold,0.92285156,77,ip,IPR036179,interpro:ip:IPR036179,9.0,2257.0,0.9892249901146698,0.16278808897156827,0.003987594151528578,,40.823635200981066,0.0,18.0,0.0,1.0,Conserved hydrophobic beta-strand edges,True,assigned_and_evaluated +16268,87882,18.72216,0.6508789,Palmitate,keyword,87882,Palmitate,0.6508789,251,keywords,Palmitate,keyword:keywords:Palmitate,6.0,2257.0,0.6427513697615873,0.009798959594041562,0.002658396101019052,,3.6860419672919673,11.0,20.0,36.63860335195531,2.8626007976676537e-15,Bacterial Sec signal peptides,True,assigned_and_evaluated +16269,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-core small hydrophobic loops,False,no_term_above_threshold +16270,46079,16.339941,0.78222656,Tetratricopeptide-like helical domain superfamily,interpro,46079,Tetratricopeptide-like helical domain superfamily,0.78222656,216,ip,IPR011990,interpro:ip:IPR011990,13.0,2257.0,0.760609488550665,0.025017071655106502,0.0057598582188746125,,4.343348517351952,0.0,20.0,0.0,1.0,Hydrophobic transmembrane/signal/coiled-coil helices,True,assigned_and_evaluated +16271,46284,31.944021,0.9790039,FMN-binding split barrel,interpro,46284,FMN-binding split barrel,0.9790039,26,ip,IPR012349,interpro:ip:IPR012349,,,,,,,,0.0,18.0,0.0,1.0,Surface-exposed connector loops,True,assigned_too_few_test_positives +16272,36104,18.258478,0.87646484,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.87646484,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,17.0,0.0,1.0,Positive-inside N-terminal signal anchor,True,assigned_too_few_test_positives +16273,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Low-complexity hinge loops,False,no_term_above_threshold +16274,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal transmembrane interface detector,False,no_term_above_threshold +16275,63831,18.333397,0.69140625,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.69140625,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.5714497260476826,0.007117290868496269,0.002658396101019052,,2.677287581699346,1.0,14.0,17.52527924750147,0.09145298269731646,Retrotransposon Pol catalytic domains,True,assigned_and_evaluated +16276,42974,16.900465,0.9321289,"Serine/threonine-protein kinase, active site",interpro,36535,Protein kinase domain,0.83251953,43,ip,IPR008271,interpro:ip:IPR008271,7.0,2257.0,0.9254285714285715,0.36253097810474855,0.0031014621178555605,0.5714285714285714,116.89034536891678,0.0,19.0,0.0,1.0,Pore-forming/fusogenic cores,True,assigned_and_evaluated +16277,-1,,,,,-1,,,0,,,,,,,,,,,,,,,GG/GxG nucleic-acid-binding beta-strand,False,no_term_above_threshold +16278,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Diffuse chain-wide activation outside domains,False,no_term_above_threshold +16279,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Post-catalytic loop motif,False,no_term_above_threshold +16280,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal beta-strand cluster,False,no_term_above_threshold +16281,50806,18.097364,0.7133789,"Homeobox, conserved site",interpro,50806,"Homeobox, conserved site",0.7133789,52,ip,IPR017970,interpro:ip:IPR017970,,,,,,,,0.0,18.0,0.0,1.0,Periplasmic coiled-coil scaffolds,True,assigned_too_few_test_positives +16282,38873,23.065508,0.7675781,AAA+ ATPase domain,interpro,38873,AAA+ ATPase domain,0.7675781,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.7985790408525755,0.460886132033673,0.002215330084182543,0.4,208.044,8.0,8.0,171.32471264367817,3.093783670371934e-18,ABC NBD signature switch,True,assigned_and_evaluated +16283,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Short His/Gly-rich active-site loops,False,no_term_above_threshold +16284,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Tubulin/FtsZ pan-chain activation,False,no_term_above_threshold +16285,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pre-NG beta-strand aliphatic motif,False,no_term_above_threshold +16286,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Redox partner docking interfaces,False,no_term_above_threshold +16287,55053,17.406065,0.9736328,Chloramphenicol acetyltransferase-like domain superfamily,interpro,85656,alpha/beta hydrolase,0.76708984,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,0.0,15.0,0.0,1.0,PAS/GAF sensory beta-sandwich,True,assigned_too_few_test_positives +16288,81685,15.925054,0.89990234,Transferase(Phosphotransferase) domain 1,gene3d,81685,Transferase(Phosphotransferase) domain 1,0.89990234,97,gene3d,1.10.510.10,gene3d:gene3d:1.10.510.10,12.0,2257.0,0.9164625092798812,0.07685882105516552,0.005316792202038104,,14.455863260125714,0.0,9.0,0.0,1.0,Amphipathic DNA-binding helices,True,assigned_and_evaluated +16289,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secondary structure linker loops,False,no_term_above_threshold +16290,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Extracellular glycan-modifying ectodomains,False,no_term_above_threshold +16291,87149,22.955873,0.6669922,Amphibian defense peptide,keyword,87149,Amphibian defense peptide,0.6669922,340,keywords,Amphibian defense peptide,keyword:keywords:Amphibian defense peptide,28.0,2257.0,0.7482855861052362,0.1558350888771908,0.012405848471422242,,12.561421271279272,0.0,15.0,0.0,1.0,Amphipathic pore forming helices,True,assigned_and_evaluated +16292,59229,27.87881,0.7446289,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.7446289,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.801963722704449,0.609784695600804,0.0101905183872397,0.6086956521739131,59.83843730308758,16.0,16.0,106.27629233511585,1.339381655082284e-32,Rossmann-like SAM MTase core,True,assigned_and_evaluated +16293,50763,16.943844,0.88427734,"Zinc finger, RING-type, conserved site",interpro,37468,"Zinc finger, RING-type",0.80908203,50,ip,IPR017907,interpro:ip:IPR017907,,,,,,,,0.0,19.0,0.0,1.0,Fimbrial chaperone and hydrolase beta-strands,True,assigned_too_few_test_positives +16294,42054,17.558327,1.0,Radical SAM,interpro,42054,Radical SAM,1.0,29,ip,IPR007197,interpro:ip:IPR007197,,,,,,,,14.0,14.0,677.5113636363636,6.4988362365136876e-40,Radical SAM core recognition,True,assigned_too_few_test_positives +16295,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Glycine-rich metal/phosphate-binding motifs,False,no_term_above_threshold +16296,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Non-cytosolic reactive beta-hairpins,False,no_term_above_threshold +16297,-1,,,,,-1,,,0,,,,,,,,,,,,,,,P/S/T/A-rich low-complexity repeats,False,no_term_above_threshold +16298,87852,16.12526,0.8569336,Nucleosome core,keyword,87852,Nucleosome core,0.8569336,56,keywords,Nucleosome core,keyword:keywords:Nucleosome core,,,,,,,,0.0,20.0,0.0,1.0,Q/N-rich low-complexity tracts,True,assigned_too_few_test_positives +16299,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Aromatic-anchored boundary helix,False,no_term_above_threshold +16300,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pseudouridine synthase catalytic core,False,no_term_above_threshold +16301,37341,20.233826,0.98339844,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9790039,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,0.9799867131705697,0.21662370506992554,0.011962782454585734,,18.10813712380822,0.0,19.0,0.0,1.0,Internal Trp-centered beta-strand motifs,True,assigned_and_evaluated +16302,43583,17.92343,0.953125,"Peptidase S1, PA clan",interpro,43583,"Peptidase S1, PA clan",0.953125,44,ip,IPR009003,interpro:ip:IPR009003,11.0,2257.0,1.0,1.0,0.004873726185201595,1.0,205.1818181818182,17.0,17.0,416.9300699300699,2.011960587844903e-44,Serine protease His–Asp interval,True,assigned_and_evaluated +16303,87105,18.376602,0.83984375,4Fe-4S,keyword,87681,Iron-sulfur,0.83251953,93,keywords,4Fe-4S,keyword:keywords:4Fe-4S,,,,,,,,6.0,9.0,99.12053200332502,1.5908143001197852e-11,Hydrogenase/NARFL C-terminal LHTxY motif,True,assigned_too_few_test_positives +16304,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding P-loop motifs,False,no_term_above_threshold +16305,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cadherin ectodomain repeat signature,False,no_term_above_threshold +16306,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Broad extracytoplasmic domain activation,False,no_term_above_threshold +16307,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Membrane-associated alpha-helix detector,False,no_term_above_threshold +16308,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Periplasmic adaptor and stalk helices,False,no_term_above_threshold +16309,-1,,,,,-1,,,0,,,,,,,,,,,,,,,NB-ARC/STAND nucleotide-binding domain,False,no_term_above_threshold +16310,27735,18.122808,0.7631836,"DNA-binding transcription factor activity, RNA polymerase II-specific",go_mf,27735,"DNA-binding transcription factor activity, RNA polymerase II-specific",0.7631836,261,go,GO:0000981,go_mf:go:GO:0000981,26.0,2257.0,0.7624297486466917,0.1111283060913425,0.011519716437749225,,9.646791801852308,0.0,16.0,0.0,1.0,Signal/TM helices and compact domains,True,assigned_and_evaluated +16311,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Active-site bridging helices,False,no_term_above_threshold +16312,-1,,,,,-1,,,0,,,,,,,,,,,,,,,C-terminal WD40 alpha-solenoid scaffolds,False,no_term_above_threshold +16313,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Catalytic-domain N-terminus motif,False,no_term_above_threshold +16314,58239,26.339315,0.6430664,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.6430664,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6452413170951737,0.19683397073042683,0.017722640673460344,0.225,11.106356798464335,15.0,15.0,35.851473241130485,1.3063198800490947e-23,C-terminal hotspots beyond P-loop,True,assigned_and_evaluated +16315,-1,,,,,-1,,,0,,,,,,,,,,,,,,,SPT16 N-terminal pita-bread motif,False,no_term_above_threshold +16316,48880,16.547638,0.8051758,"Pyridoxal phosphate-dependent transferase, major domain",interpro,48880,"Pyridoxal phosphate-dependent transferase, major domain",0.8051758,27,ip,IPR015421,interpro:ip:IPR015421,,,,,,,,4.0,19.0,102.04706889174153,1.2895433861885412e-07,Phosphate-binding catalytic core,True,assigned_too_few_test_positives +16317,-1,,,,,-1,,,0,,,,,,,,,,,,,,,pfkB phosphate-binding loop,False,no_term_above_threshold +16318,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Inner-membrane extracytoplasmic loops,False,no_term_above_threshold +16319,36104,23.896677,0.9448242,Rho GTPase-activating protein domain,interpro,36104,Rho GTPase-activating protein domain,0.9448242,31,ip,IPR000198,interpro:ip:IPR000198,,,,,,,,0.0,18.0,0.0,1.0,Internal noncatalytic structured region,True,assigned_too_few_test_positives +16320,-1,,,,,-1,,,0,,,,,,,,,,,,,,,"SPRY/pseudokinase PPI, acidic IDRs",False,no_term_above_threshold +16321,37282,21.844404,0.93408203,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.86376953,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,0.0,13.0,0.0,1.0,Pentapeptide-repeat β-helix register,True,assigned_too_few_test_positives +16322,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Functional β-strand boundary loops,False,no_term_above_threshold +16323,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Ethylene receptor GAF LDRH motif,False,no_term_above_threshold +16324,36115,22.587873,0.9975586,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.9975586,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,15.0,17.0,326.7500913408842,1.211488693421157e-36,Post-BTB helix and tail,True,assigned_too_few_test_positives +16325,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Cationic glycine-aromatic low-complexity,False,no_term_above_threshold +16326,37341,25.732964,0.99902344,WD40 repeat,interpro,49061,WD40/YVTN repeat-like-containing domain superfamily,0.9941406,97,ip,IPR001680,interpro:ip:IPR001680,27.0,2257.0,1.0,1.0,0.011962782454585734,1.0,83.5925925925926,20.0,20.0,145.4170731707317,4.960484987757626e-43,WD40 hydrophobic core register,True,assigned_and_evaluated +16327,-1,,,,,-1,,,0,,,,,,,,,,,,,,,N-terminal fold-nucleating tethers,False,no_term_above_threshold +16328,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-clamp mid-domain motif,False,no_term_above_threshold +16329,35372,17.550833,0.8149414,ABC-type transporter activity,go_mf,35372,ABC-type transporter activity,0.8149414,25,go,GO:0140359,go_mf:go:GO:0140359,,,,,,,,12.0,17.0,495.122491349481,7.590057477390118e-31,First extracellular loop after TM1,True,assigned_too_few_test_positives +16330,64058,26.288559,0.734375,NAD(P)-binding domain superfamily,interpro,85682,NAD(P)-binding Rossmann-like Domain,0.7260742,141,ip,IPR036291,interpro:ip:IPR036291,14.0,2257.0,0.9280619068849117,0.8250092311567722,0.006202924235711121,0.8571428571428571,133.00327390863106,17.0,17.0,113.99808795411089,4.31985177778818e-35,Oxidoreductase C-terminal lid,True,assigned_and_evaluated +16331,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Soluble domain interface helices,False,no_term_above_threshold +16332,37282,22.150843,0.77001953,Leucine-rich repeat,interpro,61392,Leucine-rich repeat domain superfamily,0.77001953,49,ip,IPR001611,interpro:ip:IPR001611,,,,,,,,6.0,14.0,95.69983948635632,4.748508269068862e-11,Tandem repeats and lumenal blocks,True,assigned_too_few_test_positives +16333,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Charged cytosolic coiled-coils,False,no_term_above_threshold +16334,-1,,,,,-1,,,0,,,,,,,,,,,,,,,ALAD TIM-barrel hydrophobic β-strands,False,no_term_above_threshold +16335,36914,26.289122,0.9995117,Glycosyltransferase 2-like,interpro,59211,Nucleotide-diphospho-sugar transferases,0.83691406,27,ip,IPR001173,interpro:ip:IPR001173,,,,,,,,14.0,14.0,736.0617283950618,1.9996289063569166e-40,Glycosyltransferase catalytic core region,True,assigned_too_few_test_positives +16336,64003,21.195566,0.9941406,Zinc finger C2H2 superfamily,interpro,88263,Zinc-finger,0.85302734,103,ip,IPR036236,interpro:ip:IPR036236,9.0,2257.0,0.9999505733491498,0.9888888888888892,0.003987594151528578,1.0,247.99135802469144,17.0,20.0,110.89245076586433,4.1075959724701413e-33,C2H2 zinc-finger linker/terminus signal,True,assigned_and_evaluated +16337,64585,16.786259,0.96484375,"Zinc finger, CCCH-type superfamily",interpro,46581,Nucleotide-binding alpha-beta plait domain superfamily,0.9135742,28,ip,IPR036855,interpro:ip:IPR036855,,,,,,,,2.0,20.0,67.75113636363636,0.0007172057854151612,RGG/RS-rich disordered RNA-binding IDRs,True,assigned_too_few_test_positives +16338,85664,23.88092,0.9692383,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.9692383,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,15.0,15.0,331.22777777777776,5.878944770543747e-38,Acceptor-binding helix-loop patch,True,assigned_too_few_test_positives +16339,36668,21.861221,1.0,AMP-dependent synthetase/ligase domain,interpro,69093,"ANL, N-terminal domain",0.9868164,37,ip,IPR000873,interpro:ip:IPR000873,,,,,,,,17.0,17.0,532.3303571428571,3.538165212749175e-46,ANL AMP-binding core scaffold,True,assigned_too_few_test_positives +16340,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Nucleoside hydrolase catalytic loop-helix,False,no_term_above_threshold +16341,88058,83.92382,0.87597656,Signal,keyword,88058,Signal,0.87597656,2747,keywords,Signal,keyword:keywords:Signal,206.0,2257.0,0.9043066844021149,0.6479548945217781,0.09127159946832078,0.8495145631067961,7.099195130755598,18.0,18.0,7.204954682779456,8.53289450276625e-16,Early mature N-terminal region,True,assigned_and_evaluated +16342,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase ATPase domain,False,no_term_above_threshold +16343,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pore-lining TM helices,False,no_term_above_threshold +16344,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic core domains,False,no_term_above_threshold +16345,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Phosphate-binding charged β/α junctions,False,no_term_above_threshold +16346,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Pita-bread metallohydrolase catalytic domain,False,no_term_above_threshold +16347,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Polyanion-binding basic-aromatic clefts,False,no_term_above_threshold +16348,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Histidine kinase DHp–CA interface,False,no_term_above_threshold +16349,59229,37.800507,0.9746094,S-adenosyl-L-methionine-dependent methyltransferase superfamily,interpro,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.9746094,156,ip,IPR029063,interpro:ip:IPR029063,23.0,2257.0,0.8662955898952941,0.7196805711037431,0.0101905183872397,0.7391304347826086,70.62256734700644,12.0,12.0,106.27629233511585,1.2791368554001287e-24,N-terminal regulatory helices,True,assigned_and_evaluated +16350,50869,19.923029,0.9135742,"DNA binding HTH domain, AraC-type",interpro,36499,"Zinc finger, GATA-type",0.8666992,31,ip,IPR018060,interpro:ip:IPR018060,,,,,,,,5.0,19.0,241.3805668016194,3.240513968867306e-11,Cytosolic nucleotide signaling cores,True,assigned_too_few_test_positives +16351,63831,20.768185,0.9277344,F-box-like domain superfamily,interpro,63831,F-box-like domain superfamily,0.9277344,115,ip,IPR036047,interpro:ip:IPR036047,6.0,2257.0,0.9174811195024434,0.017478271016498133,0.002658396101019052,,6.574742947372714,0.0,16.0,0.0,1.0,Alpha-helix structural signal,True,assigned_and_evaluated +16352,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helix-start N-cap marker,False,no_term_above_threshold +16353,37020,22.94435,0.99560547,"Glycosyl transferase, family 1",interpro,85664,Glycogen Phosphorylase B;,0.7919922,25,ip,IPR001296,interpro:ip:IPR001296,,,,,,,,1.0,19.0,42.985580389329485,0.0386076117710189,P/S/T-rich coiled-coil stalks,True,assigned_too_few_test_positives +16354,58239,18.443245,0.7128906,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.7128906,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.8146538114569237,0.05624628094827598,0.017722640673460344,,3.1736964025064727,4.0,11.0,13.036899360411086,0.00030820337331162744,Glycine-rich phosphate/gate loops,True,assigned_and_evaluated +16355,36115,19.12483,0.80078125,BTB/POZ domain,interpro,45551,SKP1/BTB/POZ domain superfamily,0.78515625,45,ip,IPR000210,interpro:ip:IPR000210,,,,,,,,0.0,20.0,0.0,1.0,Gly-anchored helix-break recognition loops,True,assigned_too_few_test_positives +16356,38873,16.407467,0.91552734,AAA+ ATPase domain,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.8774414,60,ip,IPR003593,interpro:ip:IPR003593,5.0,2257.0,0.8876554174067495,0.4496384683156871,0.002215330084182543,0.4,202.96680459770118,12.0,15.0,137.05977011494255,1.719201434877097e-24,AAA+ coupling helix segment,True,assigned_and_evaluated +16357,88009,18.131025,0.6171875,Repeat,keyword,88009,Repeat,0.6171875,1599,keywords,Repeat,keyword:keywords:Repeat,164.0,2257.0,0.7680537913835899,0.2590461490556869,0.07266282676118742,0.03048780487804878,3.565043648894423,5.0,13.0,3.4098370031455536,0.018323997727671924,Short interdomain interface segments,True,assigned_and_evaluated +16358,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secretory/envelope non-TM domains,False,no_term_above_threshold +16359,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Secreted protein ectodomain signature,False,no_term_above_threshold +16360,58239,23.8553,0.64697266,P-loop containing nucleoside triphosphate hydrolase,interpro,58239,P-loop containing nucleoside triphosphate hydrolase,0.64697266,466,ip,IPR027417,interpro:ip:IPR027417,40.0,2257.0,0.6768775372124493,0.1832027415127813,0.017722640673460344,0.1,10.337214689858685,15.0,15.0,35.851473241130485,1.3063198800490947e-23,STAND/AAA+ P-loop ATPase core,True,assigned_and_evaluated +16361,88153,16.174551,0.6533203,Transferase,keyword,88153,Transferase,0.6533203,965,keywords,Transferase,keyword:keywords:Transferase,119.0,2257.0,0.8298260370565438,0.17144868202963587,0.052724856003544526,,3.2517619776545224,0.0,17.0,0.0,1.0,Aromatic-glycine loop micro-motifs,True,assigned_and_evaluated +16362,83302,28.725285,0.7910156,Nucleic acid-binding proteins,gene3d,46277,"Nucleic acid-binding, OB-fold",0.79003906,80,gene3d,2.40.50.140,gene3d:gene3d:2.40.50.140,11.0,2257.0,0.8607828057961628,0.5561271778484893,0.004873726185201595,0.6363636363636364,114.10718549127641,14.0,17.0,169.30912778904664,7.59137836074535e-30,OB-fold ssDNA-binding module,True,assigned_and_evaluated +16363,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Outer-membrane assembly C-terminal domains,False,no_term_above_threshold +16364,88263,45.840527,0.9609375,Zinc-finger,keyword,29166,zinc ion binding,0.92285156,529,keywords,Zinc-finger,keyword:keywords:Zinc-finger,33.0,2257.0,0.9640900915631131,0.2547201608975503,0.014621178555604785,0.030303030303030304,17.421315246841544,5.0,20.0,6.5145323426573425,0.00139818894031626,Zinc-coordinating cysteine residues,True,assigned_and_evaluated +16365,87833,20.442968,0.7182617,Neurotoxin,keyword,87413,Disulfide bond,0.63623047,422,keywords,Neurotoxin,keyword:keywords:Neurotoxin,48.0,2257.0,0.6856090614154218,0.06043482295173873,0.021267168808152416,0.020833333333333332,2.8416957375432146,0.0,14.0,0.0,1.0,Cysteine-rich membrane anchors,True,assigned_and_evaluated +16366,-1,,,,,-1,,,0,,,,,,,,,,,,,,,7TM chemoreceptors and multipass membranes,False,no_term_above_threshold +16367,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Beta-sheet domain signature,False,no_term_above_threshold +16368,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Structural hydrophobic alpha-helices,False,no_term_above_threshold +16369,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Rossmann dinucleotide-binding domain,False,no_term_above_threshold +16370,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RTX Ca2+-binding repeats,False,no_term_above_threshold +16371,36091,19.58433,0.98828125,GNAT domain,interpro,85712,3.40.630.30,0.9658203,50,ip,IPR000182,interpro:ip:IPR000182,,,,,,,,0.0,16.0,0.0,1.0,CBS/Bateman cytosolic hydrophobic beta-strands,True,assigned_too_few_test_positives +16372,43624,16.665356,0.79785156,Homedomain-like superfamily,interpro,87384,DNA-binding,0.6513672,216,ip,IPR009057,interpro:ip:IPR009057,16.0,2257.0,0.89812025881303,0.1763684757604212,0.007089056269384138,0.0625,24.878978111954414,3.0,15.0,17.561413843888072,0.001069440350722066,Lysine-rich electrostatic/PTM hotspots,True,assigned_and_evaluated +16373,39971,31.10776,1.0,"Calcineurin-like phosphoesterase domain, ApaH type",interpro,59218,Metallo-dependent phosphatase-like,0.9863281,28,ip,IPR004843,interpro:ip:IPR004843,,,,,,,,15.0,18.0,552.0462962962963,9.336186095284716e-40,Metallophosphoesterase catalytic domains,True,assigned_too_few_test_positives +16374,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Hydrophobic helical packing cores,False,no_term_above_threshold +16375,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Oligomeric helical active site scaffold,False,no_term_above_threshold +16376,55053,24.070248,1.0,Chloramphenicol acetyltransferase-like domain superfamily,interpro,55053,Chloramphenicol acetyltransferase-like domain superfamily,1.0,35,ip,IPR023213,interpro:ip:IPR023213,,,,,,,,19.0,19.0,552.0462962962963,3.5000972430365514e-51,O-acyltransferase acceptor-binding lid,True,assigned_too_few_test_positives +16377,25167,19.386684,0.75341797,cell outer membrane,go_cc,25167,cell outer membrane,0.75341797,138,go,GO:0009279,go_cc:go:GO:0009279,12.0,2257.0,0.9549183370452858,0.5995188226356966,0.005316792202038104,0.8333333333333334,112.75949855739725,18.0,20.0,122.78924485125857,2.7850633119044632e-36,Outer-membrane beta-barrel strands,True,assigned_and_evaluated +16378,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Conserved catalytic-domain aromatic motif,False,no_term_above_threshold +16379,85664,26.964798,0.90478516,Glycogen Phosphorylase B;,gene3d,85664,Glycogen Phosphorylase B;,0.90478516,56,gene3d,3.40.50.2000,gene3d:gene3d:3.40.50.2000,,,,,,,,15.0,18.0,276.02314814814815,3.6900381356276644e-35,Nucleotide-sugar donor-binding subdomain,True,assigned_too_few_test_positives +16380,-1,,,,,-1,,,0,,,,,,,,,,,,,,,Helical/IDR scaffold activation,False,no_term_above_threshold +16381,81858,20.078245,0.9584961,Rhodopsin 7-helix transmembrane proteins,gene3d,88161,Transmembrane helix,0.67822266,48,gene3d,1.20.1070.10,gene3d:gene3d:1.20.1070.10,,,,,,,,0.0,20.0,0.0,1.0,Transmembrane helix boundary motifs,True,assigned_too_few_test_positives +16382,-1,,,,,-1,,,0,,,,,,,,,,,,,,,RasGAP YYxPLxxLL motif,False,no_term_above_threshold +16383,85649,41.386795,0.93066406,Vaccinia Virus protein VP39,gene3d,59229,S-adenosyl-L-methionine-dependent methyltransferase superfamily,0.92578125,151,gene3d,3.40.50.150,gene3d:gene3d:3.40.50.150,23.0,2257.0,0.8677260519247986,0.6731236602021227,0.0101905183872397,0.7391304347826086,66.05391743809525,2.0,19.0,11.643589493213552,0.021414253909882077,N-terminal β→α loop motif,True,assigned_and_evaluated